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- Antibody Data
- Antigen structure
- References [89]
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- Product number
- 66963-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- NFATC1 antibody
- Antibody type
- Monoclonal
- Description
- NFATC1 antibody (Cat. #66963-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1E1B10
- Vial size
- 20ul, 150ul
Submitted references Histological and epigenetic alterations in vaginal relaxation syndrome: evidence from m6A-Seq, RNA-Seq, and animal models.
7-Ketocholesterol promotes T cell migration through Ca(2+)-NFATc1 pathway-mediated F-actin polymerization and proinflammatory cytokine production in oral lichen planus.
Molybdenum nanodots reprogram inflammatory-driven osteolysis via bone immune remodeling.
Type V Collagen Directs the Differentiation of iPSCs into Valvular Endothelial-Like Cells.
Engineering multifunctional microspheres for sequential regulation of osteoimmune microenvironment and bone remodeling balance to promote regeneration of osteoporotic bone defects.
Calcium-Polyphenol Functionalized Black Phosphorus Nanosheet System for Osteoporosis Therapy via Macrophage Reprogramming and Bone Microenvironment Remodeling.
ACAT1 inhibitor Avasimibe suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via CKB/PI3K-AKT signaling.
ANGPTL8 accelerates bone loss in diabetic mice by promoting osteoclastic differentiation and inhibiting osteoblastic differentiation through AMPK pathway-mediated metabolic reprogramming.
Inhibition of MAGL ameliorates glucocorticoid-induced bone loss by regulating the Nrf2 signaling.
U0126 induces osteoclast differentiation via the p38-NFATc-1 signaling pathway.
PDK4 knockdown suppresses osteoclast differentiation in osteoporosis through glycolytic flux suppression and AMPK activation.
Multi-Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean-Type and Chinese Indigenous Pigs.
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
IgG promotes TNF-α induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF-κB signalling pathway.
Fracture-Induced Immunological Cascades Trigger Rapid Systemic Bone Loss via Osteocyte-Regulated Osteoclastogenesis.
Porphyran Inhibits Osteoclast Formation Based on NF-κB Signaling Pathways and Accelerates Alveolar Bone Healing in Ovariectomized Mice.
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
New Cyclic Lipopeptide Compounds for Efficiently Inhibiting Cellular Inflammation and Collagen-Induced Arthritis in Mice.
Orally administered degradable nanoarmor-assisted probiotics for remodeling the gut microenvironment and treating osteoporosis.
Targeting NFAT2 for Reversing the P-gp-Mediated Multidrug Resistance to Paclitaxel by Manidipine.
Calreticulin-driven immunogenic cell death promotes osteoclast differentiation and osteoarthritis progression via the LRP1/Rac1 signaling.
NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co-activator of the TGF-β1/SMAD Signaling Pathway and Inducing the Epithelial-Mesenchymal Transition in Liver Cancer.
Self-assembled water soluble and bone-targeting phosphorylated quercetin ameliorates postmenopausal osteoporosis in ovariectomy mice.
An Asymmetric Zn Membrane with Degradability, Antimicrobial, and Bone Immunomodulation for Guided Bone Regeneration.
Inhibition of stromal MAOA leading activation of WNT5A enhance prostate cancer immunotherapy by involving the transition of cancer-associated fibroblasts.
Bioengineered bacterial extracellular vesicles for targeted delivery of an osteoclastogenesis-inhibitory peptide to alleviate osteoporosis.
Porphyromonas gingivalis LPS-stimulated BMSC-derived exosome promotes osteoclastogenesis via miR-151-3p/PAFAH1B1.
The Shh-p38-NFATc1 signaling pathway is essential for osteoclastogenesis during tooth eruption.
Fraxin inhibits ovariectomized-induced bone loss and osteoclastogenesis by suppressing ROS activity.
Targeting chaperone-mediated autophagy to regulate osteoclast activity as a therapeutic strategy for osteoporosis.
Endothelial mechanosensitive transcription factor BHLHE40 induced by Piezo1 suppresses endothelial ferroptosis and inflammation via SLC7A11.
Ergothioneine alleviates osteoporosis via the ROS-MAPK signaling Axis.
Epithelial sodium channel in dendritic cells participates in high-fat-induced inflammatory responses.
ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway.
3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca(2+)-NFAT Signaling Pathways.
DPHB inhibits osteoclastogenesis by suppressing NF-κB and MAPK signaling and alleviates inflammatory bone destruction.
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway.
Yunnan Baiyao Might Mitigate Periodontitis Bone Destruction by Inhibiting Autophagy and Promoting Osteoblast Differentiation in vivo, ex vivo and in vitro.
Ginsenoside Rb3 alleviates the formation of osteoclasts induced by periodontal ligament fibroblasts in the periodontitis microenvironment through the STAT3 pathway.
Osteoclast-derived exosomes influence osteoblast differentiation in osteoporosis progression via the lncRNA AW011738/ miR-24-2-5p/ TREM1 axis.
Forskolin is an effective therapeutic small molecule for the treatment of hypertrophic cardiomyopathy through ADCY6/cAMP/PKA pathway.
Nanoscale ZnO doping in prosthetic polymers mitigate wear particle-induced inflammation and osteolysis through inhibiting macrophage secretory autophagy.
Bilobalide ameliorates osteoporosis by influencing the SIRT3/NF-κB axis in osteoclasts and promoting M2 polarization in macrophages.
Mitigation of inflammatory bowel disease-related osteoporosis by oxyberberine: Insights into the RANKL/NF-κB signaling pathway.
D-alanine suppressed osteoclastogenesis derived from bone marrow macrophages and downregulated ERK/p38 signalling pathways.
StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway.
C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis.
FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo.
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Targeting CD38/ ADP-ribosyl cyclase as a novel therapeutic strategy for identification of three potent agonists for leukopenia treatment.
Farrerol suppresses osteoclast differentiation and postmenopausal osteoporosis by inhibiting the nuclear factor kappa B signaling pathway.
Sulforaphane inhibits multiple myeloma cell-induced osteoclast differentiation and macrophage proliferation by elevating ferroportin1.
RAC1 inhibition ameliorates IBSP-induced bone metastasis in lung adenocarcinoma.
Yunnan Baiyao Inhibits Periodontitis by Suppressing the Autophagic Flux.
A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration.
The mechanism of metformin combined with total flavonoids of Rhizoma Drynariae on ovariectomy-induced osteoporotic rats.
Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation.
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.
Dietary Taurine Supplementation Improves the Meat Quality, Muscle Fiber Type, and Mitochondrial Function of Finishing Pigs.
Anti-resorption role of low-intensity pulsed ultrasound (LIPUS) during large-scale bone reconstruction using porous titanium alloy scaffolds through inhibiting osteoclast differentiation.
Metastatic prostate cancer-derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein.
An innovative immunotherapeutic strategy for rheumatoid arthritis: Selectively suppressing angiogenesis and osteoclast differentiation by fully human antibody targeting thymocyte antigen-1.
FTO-dependent m(6)A regulates muscle fiber remodeling in an NFATC1-YTHDF2 dependent manner.
Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis.
The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis.
Taurine promotes muscle fiber type transformation through CaN/NFATc1 signaling in porcine myoblasts.
CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression.
Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.
The Dibenzyl Isoquinoline Alkaloid Berbamine Ameliorates Osteoporosis by Inhibiting Bone Resorption.
Baohuoside I Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Expression Regulation of Water Reabsorption Genes and Transcription Factors in the Kidneys of Lepus yarkandensis.
A 3D-printed molybdenum-containing scaffold exerts dual pro-osteogenic and anti-osteoclastogenic effects to facilitate alveolar bone repair.
Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase : a novel approach in the prevention of osteoclastogenesis.
Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder.
Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity.
TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma.
TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway.
Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition.
Regulator of calcineurin 1 gene isoform 4 in pancreatic ductal adenocarcinoma regulates the progression of tumor cells.
4-Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF-κB signaling pathway and reverses bone loss in ovariectomized mice.
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis.
Schisandrin A restrains osteoclastogenesis by inhibiting reactive oxygen species and activating Nrf2 signalling.
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand with a Superior Therapeutic Index.
IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation.
miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN/PI3K/AKT/FoxO1 pathway.
Interactions between β-cyclodextrin and tea catechins, and potential anti-osteoclastogenesis activity of the (-)-epigallocatechin-3-gallate-β-cyclodextrin complex.
Cui D, Cui C, Yang M, Zhang L, Dai Y, Luo X
Folia morphologica 2026;85:e01726037
Folia morphologica 2026;85:e01726037
7-Ketocholesterol promotes T cell migration through Ca(2+)-NFATc1 pathway-mediated F-actin polymerization and proinflammatory cytokine production in oral lichen planus.
Jiang Q, Tang YX, Zhou G
Frontiers in immunology 2026;17:1682589
Frontiers in immunology 2026;17:1682589
Molybdenum nanodots reprogram inflammatory-driven osteolysis via bone immune remodeling.
Fu Z, Hao W, Qin X, Wang H, Xie D, Zhang M, Ni D
Biomaterials 2026 May;328:123871
Biomaterials 2026 May;328:123871
Type V Collagen Directs the Differentiation of iPSCs into Valvular Endothelial-Like Cells.
Zhang Y, Xie M, Cao H, Qiu X, Wan W, Zhou Y, Shi J, Dong N, Qiao W
Advanced healthcare materials 2026 May;15(18):e03948
Advanced healthcare materials 2026 May;15(18):e03948
Engineering multifunctional microspheres for sequential regulation of osteoimmune microenvironment and bone remodeling balance to promote regeneration of osteoporotic bone defects.
Luo Z, Ma J, Yang Y, Zhang H, Du Y, Dai J, Wang Y, Zhang W, Ma X, Lai Y
Journal of orthopaedic translation 2026 Mar;57:101054
Journal of orthopaedic translation 2026 Mar;57:101054
Calcium-Polyphenol Functionalized Black Phosphorus Nanosheet System for Osteoporosis Therapy via Macrophage Reprogramming and Bone Microenvironment Remodeling.
Deng X, Li Z, Yi X, Ruan D, Chen X, Luo J
Advanced healthcare materials 2026 Mar 13;:e04217
Advanced healthcare materials 2026 Mar 13;:e04217
ACAT1 inhibitor Avasimibe suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via CKB/PI3K-AKT signaling.
Zhao X, Cai C, Zhang Z, Tang C, Huang X, Zhang Y, Yang S, Qiu H, Wen X, Chu T
International immunopharmacology 2026 Jan 15;169:115973
International immunopharmacology 2026 Jan 15;169:115973
ANGPTL8 accelerates bone loss in diabetic mice by promoting osteoclastic differentiation and inhibiting osteoblastic differentiation through AMPK pathway-mediated metabolic reprogramming.
Tuo P, Mu W, Bai X, Wang S, Hu L, Xu Y, Mao R, Liu Y, Yuan Y, Zhang Q, Guo X, Ma S, Wang X
Cellular and molecular life sciences : CMLS 2026 Feb 23;83(1)
Cellular and molecular life sciences : CMLS 2026 Feb 23;83(1)
Inhibition of MAGL ameliorates glucocorticoid-induced bone loss by regulating the Nrf2 signaling.
Huang C, Wang X, Liu S, Xiao P, Lu Z, Xu Y, Tian Y
Free radical biology & medicine 2026 Feb 1;243:67-81
Free radical biology & medicine 2026 Feb 1;243:67-81
U0126 induces osteoclast differentiation via the p38-NFATc-1 signaling pathway.
Wang J, Liu J, Jia X, Chen G, Chen S, Huang X
Tissue & cell 2026 Apr;99:103263
Tissue & cell 2026 Apr;99:103263
PDK4 knockdown suppresses osteoclast differentiation in osteoporosis through glycolytic flux suppression and AMPK activation.
Huang Y, Zhou R, Liang R, Shen J
Bone 2026 Apr 27;209:117911
Bone 2026 Apr 27;209:117911
Multi-Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean-Type and Chinese Indigenous Pigs.
Zheng S, Wu H, Liu M, Wu K, Huang S, Ahmed Z, Pius L, Zhu M, Xu D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 17;:e23959
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 17;:e23959
γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway.
Wei J, Xie J, He Z, Feng X
Frontiers in pharmacology 2025;16:1742401
Frontiers in pharmacology 2025;16:1742401
IgG promotes TNF-α induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF-κB signalling pathway.
Yin H, Teng Y, Deng GM
Clinical & translational immunology 2025;14(5):e70034
Clinical & translational immunology 2025;14(5):e70034
Fracture-Induced Immunological Cascades Trigger Rapid Systemic Bone Loss via Osteocyte-Regulated Osteoclastogenesis.
Sun L, Kuang S, Li Y, Wang G, Sun J, Zhou F, Zhang C
ImmunoTargets and therapy 2025;14:849-875
ImmunoTargets and therapy 2025;14:849-875
Porphyran Inhibits Osteoclast Formation Based on NF-κB Signaling Pathways and Accelerates Alveolar Bone Healing in Ovariectomized Mice.
Wu P, Wang Y, Chu S, Duan Z, Wu Y, Zhao Y, Wang Y
Journal of food science 2025 Sep;90(9):e70447
Journal of food science 2025 Sep;90(9):e70447
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
Yao Z, He J, Hu M, Yan P, Xu Q, Zhang Q, Lin Y, Liao J, Cai X, Liu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
New Cyclic Lipopeptide Compounds for Efficiently Inhibiting Cellular Inflammation and Collagen-Induced Arthritis in Mice.
Ma Y, Cao X, Jin X, Huang L, Zeng D, Xia Z, Liu Y, Liang S
Journal of medicinal chemistry 2025 Sep 25;68(18):19767-19780
Journal of medicinal chemistry 2025 Sep 25;68(18):19767-19780
Orally administered degradable nanoarmor-assisted probiotics for remodeling the gut microenvironment and treating osteoporosis.
Li Z, Deng X, Qiu C, Wang Z, Tang F, Pi Y, He Z, Zheng C, Luo J
Journal of nanobiotechnology 2025 Oct 11;23(1):660
Journal of nanobiotechnology 2025 Oct 11;23(1):660
Targeting NFAT2 for Reversing the P-gp-Mediated Multidrug Resistance to Paclitaxel by Manidipine.
Zhou J, Wang N, Lin YK, Li QL, Liu RM, Hu JQ, Zhou H, Lan H, Xie Y
Cancers 2025 Oct 10;17(20)
Cancers 2025 Oct 10;17(20)
Calreticulin-driven immunogenic cell death promotes osteoclast differentiation and osteoarthritis progression via the LRP1/Rac1 signaling.
Ma Q, Lan Z, Yang Y, Sun R, Xue D, Lin X, Su Y, Ma L, Hu Z, Wu G, He X, Tian K, Jin Q
International immunopharmacology 2025 Oct 10;163:115277
International immunopharmacology 2025 Oct 10;163:115277
NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co-activator of the TGF-β1/SMAD Signaling Pathway and Inducing the Epithelial-Mesenchymal Transition in Liver Cancer.
Liu Y, Mo W, Sun W, Chen J, Chen J, Li Y, Han D, Dai W, Zhang R
Digestive diseases and sciences 2025 May;70(5):1799-1812
Digestive diseases and sciences 2025 May;70(5):1799-1812
Self-assembled water soluble and bone-targeting phosphorylated quercetin ameliorates postmenopausal osteoporosis in ovariectomy mice.
Luo P, Zhong Y, Yang X, Lai Q, Huang S, Zhang X, Zhang B, Wei Y
Colloids and surfaces. B, Biointerfaces 2025 May;249:114495
Colloids and surfaces. B, Biointerfaces 2025 May;249:114495
An Asymmetric Zn Membrane with Degradability, Antimicrobial, and Bone Immunomodulation for Guided Bone Regeneration.
Ma S, Zhao Z, Shang Y, Qi M, Xu S, Yao S, Li Y, Wang X, Tong T, Zheng H, Ma B, Yang Y, Wu J, Liu Z, Deng J
ACS applied materials & interfaces 2025 May 28;17(21):31640-31653
ACS applied materials & interfaces 2025 May 28;17(21):31640-31653
Inhibition of stromal MAOA leading activation of WNT5A enhance prostate cancer immunotherapy by involving the transition of cancer-associated fibroblasts.
Zhao Z, Hu Y, Li H, Lu T, He X, Ma Y, Huang M, Li M, Yang L, Shi C
Journal for immunotherapy of cancer 2025 Mar 22;13(3)
Journal for immunotherapy of cancer 2025 Mar 22;13(3)
Bioengineered bacterial extracellular vesicles for targeted delivery of an osteoclastogenesis-inhibitory peptide to alleviate osteoporosis.
Kong X, Liu H, Chen S, Liu Z, Chen Q, Li X, Hu H, Su J, Shi Y
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113751
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113751
Porphyromonas gingivalis LPS-stimulated BMSC-derived exosome promotes osteoclastogenesis via miR-151-3p/PAFAH1B1.
Dong JC, Liao Y, Zhou W, Sun MJ, Zhang HY, Li Y, Song ZC
Oral diseases 2025 Jan;31(1):206-216
Oral diseases 2025 Jan;31(1):206-216
The Shh-p38-NFATc1 signaling pathway is essential for osteoclastogenesis during tooth eruption.
Liu J, Wang J, Huang R, Jia X, Huang X
Tissue & cell 2025 Feb;92:102643
Tissue & cell 2025 Feb;92:102643
Fraxin inhibits ovariectomized-induced bone loss and osteoclastogenesis by suppressing ROS activity.
Zhou H, Chen P, Zhao C, Zou S, Wu H, Huang C, Hu H, Wu Q, Zhang C, Weng W
International immunopharmacology 2025 Feb 6;147:113871
International immunopharmacology 2025 Feb 6;147:113871
Targeting chaperone-mediated autophagy to regulate osteoclast activity as a therapeutic strategy for osteoporosis.
Zhang Y, Li Q, Peng X, Ji P, Zhang Y, Jin J, Yuan Z, Jiang J, Tian G, Cai M, Feng P, Wu Y, Liu W, Wang P
Materials today. Bio 2025 Dec;35:102311
Materials today. Bio 2025 Dec;35:102311
Endothelial mechanosensitive transcription factor BHLHE40 induced by Piezo1 suppresses endothelial ferroptosis and inflammation via SLC7A11.
Miao S, Dai X, Li X, Chen Z, Wang Y, Ye T, Ying Y, Yu Y, Wu A, Song H, Teng P, Ma L, Zheng Q
Cell death discovery 2025 Dec 10;12(1):47
Cell death discovery 2025 Dec 10;12(1):47
Ergothioneine alleviates osteoporosis via the ROS-MAPK signaling Axis.
Guo Z, Huang Y, Wang X, Han Y, Li A, Qu Y, Chen L, Du M, Zhang Y, Xu Y
Bone 2025 Aug;197:117496
Bone 2025 Aug;197:117496
Epithelial sodium channel in dendritic cells participates in high-fat-induced inflammatory responses.
Li X, Zhou SL, Bai L, Yu CL, Niu N
Molecular biology reports 2025 Aug 30;52(1):856
Molecular biology reports 2025 Aug 30;52(1):856
ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway.
Li Y, Yang JY, Lin ML, Liu TZ, Lu WN, Yang Y, Liu ZC, Li JH, Zhang GQ, Guo JS
Molecular medicine (Cambridge, Mass.) 2025 Apr 7;31(1):131
Molecular medicine (Cambridge, Mass.) 2025 Apr 7;31(1):131
3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca(2+)-NFAT Signaling Pathways.
Qiu X, Wu W, Zhang S, Huang C, Lin D
Journal of proteome research 2025 Apr 4;24(4):2063-2080
Journal of proteome research 2025 Apr 4;24(4):2063-2080
DPHB inhibits osteoclastogenesis by suppressing NF-κB and MAPK signaling and alleviates inflammatory bone destruction.
Liu C, Zuo M, Zhao J, Niu T, Hu A, Wang H, Zeng X
International immunopharmacology 2025 Apr 16;152:114377
International immunopharmacology 2025 Apr 16;152:114377
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway.
Song C, Yan Q, Ma Y, Li P, Yang Y, Wang Y, Li W, Wan X, Li Y, Zhu R, Liu H, Zhang Z
Drug design, development and therapy 2024;18:6359-6377
Drug design, development and therapy 2024;18:6359-6377
Yunnan Baiyao Might Mitigate Periodontitis Bone Destruction by Inhibiting Autophagy and Promoting Osteoblast Differentiation in vivo, ex vivo and in vitro.
Liu W, Li Y, An Y, Zhao R, Wei C, Ren X, He H
Journal of inflammation research 2024;17:2271-2284
Journal of inflammation research 2024;17:2271-2284
Ginsenoside Rb3 alleviates the formation of osteoclasts induced by periodontal ligament fibroblasts in the periodontitis microenvironment through the STAT3 pathway.
Zhang Y, Shi H
Cell biology international 2024 Sep;48(9):1343-1353
Cell biology international 2024 Sep;48(9):1343-1353
Osteoclast-derived exosomes influence osteoblast differentiation in osteoporosis progression via the lncRNA AW011738/ miR-24-2-5p/ TREM1 axis.
Liu J, Wang B, Chen H, Yu X, Cao X, Zhang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117231
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117231
Forskolin is an effective therapeutic small molecule for the treatment of hypertrophic cardiomyopathy through ADCY6/cAMP/PKA pathway.
Wang W, Xue Y, Li D, Shao C, Wu K, Sun N, Chen Q
European journal of pharmacology 2024 Sep 5;978:176770
European journal of pharmacology 2024 Sep 5;978:176770
Nanoscale ZnO doping in prosthetic polymers mitigate wear particle-induced inflammation and osteolysis through inhibiting macrophage secretory autophagy.
Lyu Z, Meng X, Hu F, Wu Y, Ding Y, Long T, Qu X, Wang Y
Materials today. Bio 2024 Oct;28:101225
Materials today. Bio 2024 Oct;28:101225
Bilobalide ameliorates osteoporosis by influencing the SIRT3/NF-κB axis in osteoclasts and promoting M2 polarization in macrophages.
Qin Y, Hu C, Jin J, Chao Y, Wang D, Xia F, Ruan C, Jiang C, Guan M, Zou C
International journal of biological macromolecules 2024 Nov;281(Pt 4):136504
International journal of biological macromolecules 2024 Nov;281(Pt 4):136504
Mitigation of inflammatory bowel disease-related osteoporosis by oxyberberine: Insights into the RANKL/NF-κB signaling pathway.
Chen T, Ai G, Liang G, Zeng L, Zhao D, Liu J, Dou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116523
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116523
D-alanine suppressed osteoclastogenesis derived from bone marrow macrophages and downregulated ERK/p38 signalling pathways.
Chang X, Deng J, Zhou F, Geng Z, Li X, Wang S
Archives of oral biology 2024 May;161:105912
Archives of oral biology 2024 May;161:105912
StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway.
Zhou S, Li J, Ying T, Wang Y, Wang Q, Li X, Zhao F
iScience 2024 May 17;27(5):109682
iScience 2024 May 17;27(5):109682
C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis.
Ye B, Chen B, Guo C, Xiong N, Huang Y, Li M, Lai Y, Li J, Zhou M, Wang S, Wang S, Yang N, Zhang H
Molecular therapy : the journal of the American Society of Gene Therapy 2024 May 1;32(5):1540-1560
Molecular therapy : the journal of the American Society of Gene Therapy 2024 May 1;32(5):1540-1560
FPR3 reprograms glycolytic metabolism and stemness in gastric cancer via calcium-NFATc1 pathway.
Wang L, Mao X, Yu X, Su J, Li Z, Chen Z, Ren Y, Huang H, Wang W, Zhao C, Hu Y
Cancer letters 2024 Jul 1;593:216841
Cancer letters 2024 Jul 1;593:216841
MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo.
Liu H, Chang Z, Liu S, Zhu R, Ma J, Lu X, Li L, Zhang Z
Heliyon 2024 Jan 15;10(1):e24241
Heliyon 2024 Jan 15;10(1):e24241
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Wu DZ, Zhu GZ, Zhao K, Gao JW, Cai GX, Li HZ, Huang YS, Tu C, Zhuang JS, Huang ZW, Zhong ZM
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Targeting CD38/ ADP-ribosyl cyclase as a novel therapeutic strategy for identification of three potent agonists for leukopenia treatment.
Liu Y, Zhang L, Wang L, Tang X, Wan S, Huang Q, Ran M, Shen H, Yang Y, Chiampanichayakul S, Tima S, Anuchapreeda S, Wu J
Pharmacological research 2024 Feb;200:107068
Pharmacological research 2024 Feb;200:107068
Farrerol suppresses osteoclast differentiation and postmenopausal osteoporosis by inhibiting the nuclear factor kappa B signaling pathway.
Lu W, Qi G, Yang X, Li D, Chen W, Zeng Q, Jiang Z
Journal of pharmacological sciences 2024 Feb;154(2):113-126
Journal of pharmacological sciences 2024 Feb;154(2):113-126
Sulforaphane inhibits multiple myeloma cell-induced osteoclast differentiation and macrophage proliferation by elevating ferroportin1.
Sun W, Sun J, Hu W, Luo C, Lu Z, He F, Zhao H, Zeng X, Cao D, Li J, Zhang C, Xia J
Cancer chemotherapy and pharmacology 2024 Dec 11;95(1):3
Cancer chemotherapy and pharmacology 2024 Dec 11;95(1):3
RAC1 inhibition ameliorates IBSP-induced bone metastasis in lung adenocarcinoma.
Zhang X, Liang X, Wen Y, Wu F, Gao G, Zhang L, Gu Y, Zhang J, Zhou F, Li W, Tang L, Yang X, Zhao H, Zhou C, Hirsch FR
Cell reports 2024 Aug 27;43(8):114528
Cell reports 2024 Aug 27;43(8):114528
Yunnan Baiyao Inhibits Periodontitis by Suppressing the Autophagic Flux.
Li Y, Liu W, Zhao R, An Y, Zhang M, Ren X, He H
International dental journal 2024 Apr;74(2):284-293
International dental journal 2024 Apr;74(2):284-293
A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration.
Hao Z, Feng Q, Wang Y, Wang Y, Li H, Hu Y, Chen T, Wang J, Chen R, Lv X, Yang Z, Chen J, Guo X, Li J
Bioactive materials 2024 Apr;34:181-203
Bioactive materials 2024 Apr;34:181-203
The mechanism of metformin combined with total flavonoids of Rhizoma Drynariae on ovariectomy-induced osteoporotic rats.
Jiang N, Jin H, Yang K, Zhang Z, Xu W, Chen X, Zhang Z, Xu H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115181
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115181
Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation.
Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N, Xiao C, Liu WH
Cellular & molecular immunology 2023 Oct;20(10):1127-1139
Cellular & molecular immunology 2023 Oct;20(10):1127-1139
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.
Zheng C, Yu X, Xu T, Liu Z, Jiang Z, Xu J, Yang J, Zhang G, He Y, Yang H, Shi X, Li Z, Liu J, Xu WW
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4217-4233
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4217-4233
Dietary Taurine Supplementation Improves the Meat Quality, Muscle Fiber Type, and Mitochondrial Function of Finishing Pigs.
An W, Huang Z, Mao Z, Qiao T, Jia G, Zhao H, Liu G, Chen X
Journal of agricultural and food chemistry 2023 Oct 18;71(41):15331-15340
Journal of agricultural and food chemistry 2023 Oct 18;71(41):15331-15340
Anti-resorption role of low-intensity pulsed ultrasound (LIPUS) during large-scale bone reconstruction using porous titanium alloy scaffolds through inhibiting osteoclast differentiation.
Luo L, Cao H, Zhou L, Zhang G, Wu L
Biomaterials advances 2023 Nov;154:213634
Biomaterials advances 2023 Nov;154:213634
Metastatic prostate cancer-derived extracellular vesicles facilitate osteoclastogenesis by transferring the CDCP1 protein.
Urabe F, Kosaka N, Yamamoto Y, Ito K, Otsuka K, Soekmadji C, Egawa S, Kimura T, Ochiya T
Journal of extracellular vesicles 2023 Mar;12(3):e12312
Journal of extracellular vesicles 2023 Mar;12(3):e12312
An innovative immunotherapeutic strategy for rheumatoid arthritis: Selectively suppressing angiogenesis and osteoclast differentiation by fully human antibody targeting thymocyte antigen-1.
Hu X, Li M, Zhang Y, Sang K, Zhang Y, Li W, Liu B, Wan L, Du B, Qian J, Meng F, Fu Y, Dai M, Gao G, Ye H
Experimental cell research 2023 Mar 1;424(1):113490
Experimental cell research 2023 Mar 1;424(1):113490
FTO-dependent m(6)A regulates muscle fiber remodeling in an NFATC1-YTHDF2 dependent manner.
Wang W, Du X, Luo M, Yang N
Clinical epigenetics 2023 Jul 5;15(1):109
Clinical epigenetics 2023 Jul 5;15(1):109
Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis.
Zhang J, Zhang Y, Feng D, Zhou H, Gui Z, Zheng M, Hang Z, Gu M, Tan R
Cell death discovery 2023 Jul 28;9(1):271
Cell death discovery 2023 Jul 28;9(1):271
The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis.
Yang T, Hei R, Li X, Ma T, Shen Y, Liu C, He W, Zhu L, Gu Y, Hu Y, Wei W, Shen Y
Cellular & molecular biology letters 2023 Jul 27;28(1):60
Cellular & molecular biology letters 2023 Jul 27;28(1):60
Taurine promotes muscle fiber type transformation through CaN/NFATc1 signaling in porcine myoblasts.
An W, Huang Z, Mao Z, Jia G, Zhao H, Liu G, Chen X
Journal of cellular physiology 2023 Dec;238(12):2879-2887
Journal of cellular physiology 2023 Dec;238(12):2879-2887
CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression.
Jin Z, Zhao L, Chang Y, Jin R, Hu F, Wu S, Xue Z, Ma Y, Chen C, Zheng M, Chang Y, Jin H, Xie Q, Huang C, Huang H
Cell death & disease 2023 Aug 26;14(8):563
Cell death & disease 2023 Aug 26;14(8):563
Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.
Chen T, Zhang X, Ding X, Feng J, Zhang X, Xie D, Wang X
Molecular oncology 2023 Apr;17(4):695-709
Molecular oncology 2023 Apr;17(4):695-709
The Dibenzyl Isoquinoline Alkaloid Berbamine Ameliorates Osteoporosis by Inhibiting Bone Resorption.
Zhang C, Zhong Z, Sang W, Ghorbani F, Ghalandari B, Mohamadali M, Irani S, Qian Z, Yi C, Yu B
Frontiers in endocrinology 2022;13:885507
Frontiers in endocrinology 2022;13:885507
Baohuoside I Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Ma M, Fan AY, Liu Z, Yang LQ, Huang JM, Pang ZY, Yin F
Frontiers in pharmacology 2022;13:874952
Frontiers in pharmacology 2022;13:874952
Expression Regulation of Water Reabsorption Genes and Transcription Factors in the Kidneys of Lepus yarkandensis.
Luo S, Li Y, Li S, Jiang R, Deng F, Liu G, Zhang J
Frontiers in physiology 2022;13:856427
Frontiers in physiology 2022;13:856427
A 3D-printed molybdenum-containing scaffold exerts dual pro-osteogenic and anti-osteoclastogenic effects to facilitate alveolar bone repair.
Tian B, Li X, Zhang J, Zhang M, Gan D, Deng D, Sun L, He X, Wu C, Chen F
International journal of oral science 2022 Sep 5;14(1):45
International journal of oral science 2022 Sep 5;14(1):45
Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase : a novel approach in the prevention of osteoclastogenesis.
Zhang Y, Jiang B, Zhang P, Chiu SK, Lee MH
Bone & joint research 2022 Nov;11(11):763-776
Bone & joint research 2022 Nov;11(11):763-776
Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder.
Chiu HW, Hou YC, Lu CL, Lu KC, Liu WC, Shyu JF, Chang JF, Zheng CM
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Feb;37(2):215-225
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Feb;37(2):215-225
Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity.
Huang JM, Wang CZ, Lu SY, Wang Z, Yan ZQ
Drug design, development and therapy 2021;15:4811-4825
Drug design, development and therapy 2021;15:4811-4825
TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma.
Bao S, Jiang X, Jin S, Tu P, Lu J
Frontiers in oncology 2021;11:694145
Frontiers in oncology 2021;11:694145
TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway.
Lin DC, Zheng SY, Zhang ZG, Luo JH, Zhu ZL, Li L, Chen LS, Lin X, Sham JSK, Lin MJ, Zhou RX
Cancer letters 2021 Oct 28;519:211-225
Cancer letters 2021 Oct 28;519:211-225
Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition.
Jia X, Zhu H, Li G, Lan M, Li X, Huang M, Xu W, Wu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111321
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111321
Regulator of calcineurin 1 gene isoform 4 in pancreatic ductal adenocarcinoma regulates the progression of tumor cells.
Lao M, Zhang X, Ma T, Xu J, Yang H, Duan Y, Ying H, Zhang X, Guo C, Qiu J, Bai X, Liang T
Oncogene 2021 Apr;40(17):3136-3151
Oncogene 2021 Apr;40(17):3136-3151
4-Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF-κB signaling pathway and reverses bone loss in ovariectomized mice.
Yi W, Liu T, Gao X, Xie Y, Liu M
Experimental and therapeutic medicine 2021 Apr;21(4):354
Experimental and therapeutic medicine 2021 Apr;21(4):354
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Qi D, Liu H, Sun X, Luo D, Zhu M, Tao T, Gao C, Zhou C, Zhou W, Xiao J
Frontiers in pharmacology 2020;11:621110
Frontiers in pharmacology 2020;11:621110
Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL-induced osteoclastogenesis.
Qian Z, Zhong Z, Ni S, Li D, Zhang F, Zhou Y, Kang Z, Qian J, Yu B
Journal of cellular and molecular medicine 2020 Sep;24(17):10112-10127
Journal of cellular and molecular medicine 2020 Sep;24(17):10112-10127
Schisandrin A restrains osteoclastogenesis by inhibiting reactive oxygen species and activating Nrf2 signalling.
Ni S, Qian Z, Yuan Y, Li D, Zhong Z, Ghorbani F, Zhang X, Zhang F, Zhang Z, Liu Z, Yu B
Cell proliferation 2020 Oct;53(10):e12882
Cell proliferation 2020 Oct;53(10):e12882
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
Wu L, Lin W, Liao Q, Wang H, Lin C, Tang L, Lian W, Chen Z, Li K, Xu L, Zhou R, Ding Y, Zhao L
Cell reports 2020 Oct 27;33(4):108327
Cell reports 2020 Oct 27;33(4):108327
Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand with a Superior Therapeutic Index.
Rinotas V, Papakyriakou A, Violitzi F, Papaneophytou C, Ouzouni MD, Alexiou P, Strongilos A, Couladouros E, Kontopidis G, Eliopoulos E, Douni E
Journal of medicinal chemistry 2020 Oct 22;63(20):12043-12059
Journal of medicinal chemistry 2020 Oct 22;63(20):12043-12059
IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation.
Hu J, Gao N, Zhang Y, Chen X, Li J, Bian F, Chi W, Liu Z, de Paiva CS, Pflugfelder SC, Li DQ
Mucosal immunology 2020 Nov;13(6):919-930
Mucosal immunology 2020 Nov;13(6):919-930
miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN/PI3K/AKT/FoxO1 pathway.
Lou Z, Peng Z, Wang B, Li X, Li X, Zhang X
Journal of bone and mineral metabolism 2019 Sep;37(5):815-824
Journal of bone and mineral metabolism 2019 Sep;37(5):815-824
Interactions between β-cyclodextrin and tea catechins, and potential anti-osteoclastogenesis activity of the (-)-epigallocatechin-3-gallate-β-cyclodextrin complex.
Xu H, Liu T, Xu J, Li J, Chen F, Xiang Z, Huang Y, Zhang D, Hu L, Zhang B, Zi C, Wang X, Sheng J
RSC advances 2019 Sep 3;9(48):28006-28018
RSC advances 2019 Sep 3;9(48):28006-28018
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