10252-1-AP

antibody from Proteintech Group

Targeting: CDC20 CDC20A, p55CDC

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

10252-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10252-1-AP, RRID:AB_2229016

Product name

Cdc20 antibody

Antibody type

Polyclonal

Description

KD/KO validated Cdc20 antibody (Cat. #10252-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Characteristics of chromosomal instability‑related lncRNAs associated with progression and prognosis in breast cancer.

Chen Q, Chen H, Yang H, Tao Y, Zhu X
Molecular medicine reports 2026 May;33(5)

---

Inhibition of CDC20 suppresses the development and progression of mantle cell lymphoma through PI3K/AKT pathway.

Chen Y, Yang P, Gao S, Liu S, Wang J, Zhang W, Jing H
Annals of hematology 2026 Mar 9;105(4)

---

Deubiquitinase USP8 regulates the spindle assembly checkpoint in oocytes.

Zhou 周长银 C, Zhang 张雪 X, Xu 许根露 G, Wang 王慧 H, Ran 冉宇婷 Y, Li 李昂 A, Sun 孙青原 QY, Ou 欧湘红 XH
Science advances 2026 Mar 13;12(11):eaeb2345

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Multi-omics analysis of core E3 ubiquitin ligase identifies prognostic biomarkers associated with immune infiltration and drug sensitivity in lung adenocarcinoma.

Shi YX, Wang J, Jiang ZL, Yan JH
Journal of Cancer 2025;16(4):1363-1378

---

Histone-related gene WDR77 promotes tumor progression through cell cycle regulation in skin cutaneous melanoma.

Zhang H, Tang K, Liu Y, Liu S
Frontiers in immunology 2025;16:1611112

---

HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression.

Zhong J, Shi S, Peng W, Cui H, Sun X
Genes & diseases 2025 May;12(3):101433

---

The Hypoxia-Associated High-Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma.

Wan Q, Wu X, Zhou J, Wu W, Cao Y, Sun C, Li Z, Gong Z, Tang H, Li Q, Chu J, Wang Q, Cui K, Lu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2416231

---

NSUN4 Facilitates the Activity of Oncogenic Protein CDC20 to Promote NSCLC Development by Mediating m5C Modification of CDC20 mRNA.

Li Z, Wu X
Thoracic cancer 2025 Mar;16(5):e70023

---

c-Jun promotes neuroblastoma cell differentiation by inhibiting APC formation via CDC16 and reduces neuroblastoma malignancy.

Wang Y, Huang J, Song Z, Zhang S, Guo H, Leng Q, Fang N, Ji S, Yang J
Biology direct 2025 Mar 27;20(1):37

---

The RNA-stability-independent role of the RNA m(6)A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance.

Liu T, Yang D, Wei Q, Wang Y, Tian L, Liu X, Yang Y, Luo Q, Xu J, Liu Y, Yang C, Zuo X, Luo F, Luo X, Zhao H, Li L, Xu J, Yu J, Ma S, Yu J, Yi P
Molecular cell 2025 Jun 19;85(12):2320-2336.e9

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Significant prognostic value of cell-cycle proteins in early-stage small cell carcinoma of cervix.

Xu Q, Zhou H, Wu J, Chang B, Gu Y, Li H, Cheng X
Scientific reports 2025 Jul 24;15(1):26860

---

BTNL9 exerts anti-cancer effects by inhibiting CDC20 to induce G2/M arrest in pancreatic cancer.

Xiao M, Luo ZY, Yu AR, Xu K, Zhou W
World journal of gastrointestinal oncology 2025 Jul 15;17(7):108274

---

A Microtubule-Associated Protein Functions in Preventing Oocytes from Evading the Spindle Assembly Checkpoint.

Zhou C, Zhang X, Xu G, Ran Y, Wang H, Xie X, Li A, Li F, Li X, Ding J, Zhang M, Sun QY, Ou XH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2413097

---

CDC20-Mediated Selective Autophagy Degradation of PBRM1 Affects Immunotherapy for Renal Cell Carcinoma.

Fan Y, Dan W, Que T, Wei Y, Liu B, Wang Z, Zhang Y, Wang Y, Liu T, Zhuang Y, Li M, Guo C, Zeng J, Ma B, Li L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2412967

---

WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer.

Sobajima T, Fulcher LJ, Batley C, Alsop SJ, Veakins J, Barr FA
The EMBO journal 2025 Aug;44(15):4378-4405

---

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan.

Adam N, Yang Y, Djamshidi M, Seifan S, Ting NSY, Glover J, Touret N, Gordon PMK, Vineetha Warriyar KV, Krowicki H, Garcia CK, Savage SA, Goodarzi AA, Baird DM, Beattie TL, Riabowol K
Aging cell 2025 Aug;24(8):e70105

---

Identification and validation of CDC20 and ITCH as ubiquitination related biomarker in idiopathic pulmonary fibrosis.

Sun S, Wang Y, Feng J
Hereditas 2025 Apr 1;162(1):50

---

Prognostic and Immune Landscape Analysis of Ubiquitination-related Genes in Hepatocellular Carcinoma: Based on Bulk and Single-cell RNA Sequencing Data.

Yuan Z, Zhu Q, Wu Q, Zhang Z, Guo J, Wu G, Zheng C, Xu Q, Huang D, Cui D
Journal of Cancer 2024;15(9):2580-2600

---

The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer.

Lin Y, Kong L, Zhao Y, Zhai F, Zhan Z, Li Y, Jingfei Z, Chunhong Y, Jin X
Journal of molecular medicine (Berlin, Germany) 2024 Nov;102(11):1395-1410

---

Repurposing colforsin daropate to treat MYC-driven high-grade serous ovarian carcinomas.

Knarr MJ, Moon J, Rawat P, DiFeo A, Hoon DSB, Drapkin R
Science signaling 2024 Nov 19;17(863):eado8303

---

DTL promotes the growth and migration of melanoma cells through the ERK/E2F1/BUB1 axis.

Xuan X, Cao J, Chen L, Zhang J, Qian Y, Huang C
Scientific reports 2024 Nov 1;14(1):26288

---

Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis.

Ni K, Li ZL, Hu ZY, Hong L
Current medical science 2024 Jun;44(3):623-632

---

STEAP4 with copper reductase activity suppresses tumorigenesis by regulating the cell cycle in hepatocellular carcinoma cells.

Yang T, Zou M, Xie Y, Zhang Y, Wang K, Jiang S, Zou Q
Cell division 2024 Dec 24;19(1):35

---

CDC20 Holds Novel Regulation Mechanism in RPA1 during Different Stages of DNA Damage to Induce Radio-Chemoresistance.

Gao Y, Wen P, Shao C, Ye C, Chen Y, You J, Su Z
International journal of molecular sciences 2024 Aug 1;25(15)

---

Bioinformatics analysis and experimental validation reveal that CDC20 overexpression promotes bladder cancer progression and potential underlying mechanisms.

Liu Y, Zou SH, Gao X
Genes & genomics 2024 Apr;46(4):437-449

---

Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma.

Zhang X, Chen J, Zhang M, Liu S, Wang T, Wu T, Li B, Zhao S, Wang H, Li L, Wang C, Huang L
Aging 2023 Sep 21;15(18):9822-9841

---

CCT6A is associated with CDC20, Enneking stage and prognosis in osteosarcoma, and its knockdown suppresses osteosarcoma cell viability and invasion.

Wang N, Chen Y, Wu J
Oncology letters 2023 May;25(5):201

---

p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma.

Chen Y, Yang P, Wang J, Gao S, Xiao S, Zhang W, Zhu M, Wang Y, Ke X, Jing H
Experimental hematology & oncology 2023 Mar 7;12(1):28

---

DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation.

Xu X, Chang CW, Li M, Omabe K, Le N, Chen YH, Liang F, Liu Y
Nature communications 2023 Mar 4;14(1):1233

---

KIF2C Facilitates Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma.

Huang X, Zhao F, Wu Q, Wang Z, Ren H, Zhang Q, Wang Z, Xu J
Cancers 2023 Feb 27;15(5)

---

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.

Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7

---

Quantitative transcriptomic and proteomic analysis reveals corosolic acid inhibiting bladder cancer via suppressing cell cycle and inducing mitophagy in vitro and in vivo.

Cui A, Li X, Ma X, Song Z, Wang X, Wang C, Xia Y
Toxicology and applied pharmacology 2023 Dec 1;480:116749

---

CDC20 is a potential target gene to inhibit the tumorigenesis of MDCK cells.

Liu Z, Pei M, Liu G, Qiu Z, Wang S, Qiao Z, Wang J, Jin D, Zhang J, Duan K, Nian X, Ma Z, Yang X
Biologicals : journal of the International Association of Biological Standardization 2023 Aug;83:101697

---

Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer.

Wu F, Wang M, Zhong T, Xiao C, Chen X, Huang Y, Wu M, Yu J, Chen D
Experimental hematology & oncology 2023 Aug 1;12(1):67

---

The Prognostic Assessment of CDC20 in Patients with Renal Clear Cell Carcinoma and Its Relationship with Body Immunity.

Shi J, Chen Y, Gu X, Wang X, Liu J, Chen X
Contrast media & molecular imaging 2022;2022:7727539

---

CDCA3 Predicts Poor Prognosis and Affects CD8(+) T Cell Infiltration in Renal Cell Carcinoma.

Bai Y, Liao S, Yin Z, You B, Lu D, Chen Y, Chen D, Wu Y
Journal of oncology 2022;2022:6343760

---

Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.

Mengyan X, Kun D, Xinming J, Yutian W, Yongqian S
Frontiers in pharmacology 2022;13:997842

---

The bioinformatics and experimental analysis of the novel roles of virus infection-associated gene CDC20 for prognosis and immune infiltration in hepatocellular carcinoma.

Li J, Zhang X, Yao L, Hu K
Aging 2022 May 27;14(10):4513-4529

---

Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.

Liu Y, Li J, Xu N, Yu H, Gong L, Li Q, Yang Z, Li S, Yang J, Huang D, Xue Y, Xue G, Liu J, Chen H, Zhang R, Li A, Zhao Y, Li P, Li M, Liu M, Wang N, Cai B
Journal of advanced research 2022 Jul;39:275-289

---

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626

---

TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells.

Yamada C, Morooka A, Miyazaki S, Nagai M, Mase S, Iemura K, Tasnin MN, Takuma T, Nakamura S, Morshed S, Koike N, Mostofa MG, Rahman MA, Sharmin T, Katsuta H, Ohara K, Tanaka K, Ushimaru T
iScience 2022 Feb 18;25(2):103675

---

CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.

Zhao S, Zhang Y, Lu X, Ding H, Han B, Song X, Miao H, Cui X, Wei S, Liu W, Chen S, Wang J
International journal of biological sciences 2021;17(13):3608-3621

---

The Oncogenic Role of APC/C Activator Protein Cdc20 by an Integrated Pan-Cancer Analysis in Human Tumors.

Wu F, Sun Y, Chen J, Li H, Yao K, Liu Y, Liu Q, Lu J
Frontiers in oncology 2021;11:721797

---

Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis.

Wang X, Ning Y, Zhang P, Poulet B, Huang R, Gong Y, Hu M, Li C, Zhou R, Lammi MJ, Guo X
Cell death & disease 2021 May 27;12(6):551

---

Identification of biomarkers for the transition from low-grade glioma to secondary glioblastoma by an integrated bioinformatic analysis.

Zhao L, Zhang J, Liu Z, Zhao P
American journal of translational research 2020;12(4):1222-1238

---

Ursolic Acid Regulates Cell Cycle and Proliferation in Colon Adenocarcinoma by Suppressing Cyclin B1.

Yang M, Hu C, Cao Y, Liang W, Yang X, Xiao T
Frontiers in pharmacology 2020;11:622212

---

Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.

Gao Y, Wen P, Chen B, Hu G, Wu L, Xu A, Zhao G
International journal of molecular sciences 2020 Sep 12;21(18)

---

Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit.

Holder J, Mohammed S, Barr FA
eLife 2020 Sep 1;9

---

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.

Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;

---

A Cdh1-FoxM1-Apc axis controls muscle development and regeneration.

Chen Z, Li L, Xu S, Liu Z, Zhou C, Li Z, Liu Y, Wu W, Huang Y, Kuang M, Fan S, Li H, Li X, Song G, Wu WS, Chen J, Hou Y
Cell death & disease 2020 Mar 9;11(3):180

---

Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.

He Y, Li R, Gu L, Deng H, Zhao Y, Guo Y, Yu S, Wang G
Cell biochemistry and function 2020 Jun;38(4):451-459

---

CDC20 Knockdown and Acidic Microenvironment Collaboratively Promote Tumorigenesis through Inhibiting Autophagy and Apoptosis.

Gu Q, Li F, Ge S, Zhang F, Jia R, Fan X
Molecular therapy oncolytics 2020 Jun 26;17:94-106

---

Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.

Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E
Molecular cell 2020 Dec 3;80(5):876-891.e6

---

Translation control of the immune checkpoint in cancer and its therapeutic targeting.

Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham JT, Ruggero D
Nature medicine 2019 Feb;25(2):301-311

---

Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.

Huang Y, Wang H, Lian Y, Wu X, Zhou L, Wang J, Deng M, Huang Y
Cell death & disease 2018 Feb 2;9(2):141

---

Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis.

Ikeda M, Tanaka K
Scientific reports 2017 Aug 18;7(1):8794

---

Evaluation of the Antitumor Efficacy of RNAi-Mediated Inhibition of CDC20 and Heparanase in an Orthotopic Liver Tumor Model.

Liu M, Zhang Y, Liao Y, Chen Y, Pan Y, Tian H, Zhan Y, Liu D
Cancer biotherapy & radiopharmaceuticals 2015 Aug;30(6):233-9

---

Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.

Wu J, Chen W, Yin Y, Zheng Z, Zou G
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Cdc20 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Cdc20. This antibody recognizes human,mouse,rat antigen. The Cdc20 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

10252-1-AP.pdf

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