10252-1-AP

antibody from Proteintech Group

Targeting: CDC20 CDC20A, p55CDC

Provider product page for 10252-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [34]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 10252-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10252-1-AP, RRID:AB_2229016
Product name: Cdc20 antibody
Antibody type: Polyclonal
Description: KD/KO validated Cdc20 antibody (Cat. #10252-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CDC20 protein structure - 10252-1-AP shown in red.

Submitted references Prognostic and Immune Landscape Analysis of Ubiquitination-related Genes in Hepatocellular Carcinoma: Based on Bulk and Single-cell RNA Sequencing Data.

Yuan Z, Zhu Q, Wu Q, Zhang Z, Guo J, Wu G, Zheng C, Xu Q, Huang D, Cui D
Journal of Cancer 2024;15(9):2580-2600

Bioinformatics analysis and experimental validation reveal that CDC20 overexpression promotes bladder cancer progression and potential underlying mechanisms.

Liu Y, Zou SH, Gao X
Genes & genomics 2024 Apr;46(4):437-449

Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma.

Zhang X, Chen J, Zhang M, Liu S, Wang T, Wu T, Li B, Zhao S, Wang H, Li L, Wang C, Huang L
Aging 2023 Sep 21;15(18):9822-9841

CCT6A is associated with CDC20, Enneking stage and prognosis in osteosarcoma, and its knockdown suppresses osteosarcoma cell viability and invasion.

Wang N, Chen Y, Wu J
Oncology letters 2023 May;25(5):201

p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma.

Chen Y, Yang P, Wang J, Gao S, Xiao S, Zhang W, Zhu M, Wang Y, Ke X, Jing H
Experimental hematology & oncology 2023 Mar 7;12(1):28

DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation.

Xu X, Chang CW, Li M, Omabe K, Le N, Chen YH, Liang F, Liu Y
Nature communications 2023 Mar 4;14(1):1233

KIF2C Facilitates Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma.

Huang X, Zhao F, Wu Q, Wang Z, Ren H, Zhang Q, Wang Z, Xu J
Cancers 2023 Feb 27;15(5)

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.

Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7

Quantitative transcriptomic and proteomic analysis reveals corosolic acid inhibiting bladder cancer via suppressing cell cycle and inducing mitophagy in vitro and in vivo.

Cui A, Li X, Ma X, Song Z, Wang X, Wang C, Xia Y
Toxicology and applied pharmacology 2023 Dec 1;480:116749

CDC20 is a potential target gene to inhibit the tumorigenesis of MDCK cells.

Liu Z, Pei M, Liu G, Qiu Z, Wang S, Qiao Z, Wang J, Jin D, Zhang J, Duan K, Nian X, Ma Z, Yang X
Biologicals : journal of the International Association of Biological Standardization 2023 Aug;83:101697

Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer.

Wu F, Wang M, Zhong T, Xiao C, Chen X, Huang Y, Wu M, Yu J, Chen D
Experimental hematology & oncology 2023 Aug 1;12(1):67

The Prognostic Assessment of CDC20 in Patients with Renal Clear Cell Carcinoma and Its Relationship with Body Immunity.

Shi J, Chen Y, Gu X, Wang X, Liu J, Chen X
Contrast media & molecular imaging 2022;2022:7727539

CDCA3 Predicts Poor Prognosis and Affects CD8(+) T Cell Infiltration in Renal Cell Carcinoma.

Bai Y, Liao S, Yin Z, You B, Lu D, Chen Y, Chen D, Wu Y
Journal of oncology 2022;2022:6343760

Identification and verification of hub genes associated with the progression of non-small cell lung cancer by integrated analysis.

Mengyan X, Kun D, Xinming J, Yutian W, Yongqian S
Frontiers in pharmacology 2022;13:997842

The bioinformatics and experimental analysis of the novel roles of virus infection-associated gene CDC20 for prognosis and immune infiltration in hepatocellular carcinoma.

Li J, Zhang X, Yao L, Hu K
Aging 2022 May 27;14(10):4513-4529

Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.

Liu Y, Li J, Xu N, Yu H, Gong L, Li Q, Yang Z, Li S, Yang J, Huang D, Xue Y, Xue G, Liu J, Chen H, Zhang R, Li A, Zhao Y, Li P, Li M, Liu M, Wang N, Cai B
Journal of advanced research 2022 Jul;39:275-289

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626

TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells.

Yamada C, Morooka A, Miyazaki S, Nagai M, Mase S, Iemura K, Tasnin MN, Takuma T, Nakamura S, Morshed S, Koike N, Mostofa MG, Rahman MA, Sharmin T, Katsuta H, Ohara K, Tanaka K, Ushimaru T
iScience 2022 Feb 18;25(2):103675

CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.

Zhao S, Zhang Y, Lu X, Ding H, Han B, Song X, Miao H, Cui X, Wei S, Liu W, Chen S, Wang J
International journal of biological sciences 2021;17(13):3608-3621

The Oncogenic Role of APC/C Activator Protein Cdc20 by an Integrated Pan-Cancer Analysis in Human Tumors.

Wu F, Sun Y, Chen J, Li H, Yao K, Liu Y, Liu Q, Lu J
Frontiers in oncology 2021;11:721797

Comparison of the major cell populations among osteoarthritis, Kashin-Beck disease and healthy chondrocytes by single-cell RNA-seq analysis.

Wang X, Ning Y, Zhang P, Poulet B, Huang R, Gong Y, Hu M, Li C, Zhou R, Lammi MJ, Guo X
Cell death & disease 2021 May 27;12(6):551

Identification of biomarkers for the transition from low-grade glioma to secondary glioblastoma by an integrated bioinformatic analysis.

Zhao L, Zhang J, Liu Z, Zhao P
American journal of translational research 2020;12(4):1222-1238

Ursolic Acid Regulates Cell Cycle and Proliferation in Colon Adenocarcinoma by Suppressing Cyclin B1.

Yang M, Hu C, Cao Y, Liang W, Yang X, Xiao T
Frontiers in pharmacology 2020;11:622212

Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.

Gao Y, Wen P, Chen B, Hu G, Wu L, Xu A, Zhao G
International journal of molecular sciences 2020 Sep 12;21(18)

Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit.

Holder J, Mohammed S, Barr FA
eLife 2020 Sep 1;9

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.

Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;

Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.

He Y, Li R, Gu L, Deng H, Zhao Y, Guo Y, Yu S, Wang G
Cell biochemistry and function 2020 Jun;38(4):451-459

CDC20 Knockdown and Acidic Microenvironment Collaboratively Promote Tumorigenesis through Inhibiting Autophagy and Apoptosis.

Gu Q, Li F, Ge S, Zhang F, Jia R, Fan X
Molecular therapy oncolytics 2020 Jun 26;17:94-106

Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.

Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E
Molecular cell 2020 Dec 3;80(5):876-891.e6

Translation control of the immune checkpoint in cancer and its therapeutic targeting.

Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham JT, Ruggero D
Nature medicine 2019 Feb;25(2):301-311

Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.

Huang Y, Wang H, Lian Y, Wu X, Zhou L, Wang J, Deng M, Huang Y
Cell death & disease 2018 Feb 2;9(2):141

Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis.

Ikeda M, Tanaka K
Scientific reports 2017 Aug 18;7(1):8794

Evaluation of the Antitumor Efficacy of RNAi-Mediated Inhibition of CDC20 and Heparanase in an Orthotopic Liver Tumor Model.

Liu M, Zhang Y, Liao Y, Chen Y, Pan Y, Tian H, Zhan Y, Liu D
Cancer biotherapy & radiopharmaceuticals 2015 Aug;30(6):233-9

Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.

Wu J, Chen W, Yin Y, Zheng Z, Zou G
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Cdc20 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Cdc20. This antibody recognizes human,mouse,rat antigen. The Cdc20 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 10252-1-AP.pdf

: Show more