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- References [17]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 10495-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10495-1-AP, RRID:AB_2163943
- Product name
- PIN1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PIN1 antibody (Cat. #10495-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway.
Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock.
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Cobalt induces neurodegenerative damages through Pin1 inactivation in mice and human neuroglioma cells.
Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation.
Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis.
LGR5 induces β-catenin activation and augments tumour progression by activating STAT3 in human intrahepatic cholangiocarcinoma.
Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.
Halo and Pseudohalo Gold(I)-NHC Complexes Derived from 4,5-Diarylimidazoles with Excellent In Vitro and In Vivo Anticancer Activities Against HCC.
Deficiency of microRNA-628-5p promotes the progression of gastric cancer by upregulating PIN1.
The peptidyl-prolyl cis/trans isomerase Pin1 interacts with three early regulatory proteins of human cytomegalovirus.
TGF-β1-PML SUMOylation-peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis.
Cellular glucose metabolism is essential for the reduction of cell-impermeable water-soluble tetrazolium (WST) dyes.
Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway.
The Essential Role of Pin1 via NF-κB Signaling in Vascular Inflammation and Atherosclerosis in ApoE-/- Mice.
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
Pin1 promotes GR transactivation by enhancing recruitment to target genes.
Zhang Y, Lv Z, Liu Y, Cao H, Yang J, Wang B
Oxidative medicine and cellular longevity 2021;2021:9980444
Oxidative medicine and cellular longevity 2021;2021:9980444
Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock.
Dong R, Xue Z, Fan G, Zhang N, Wang C, Li G, Da Y
Frontiers in immunology 2021;12:620238
Frontiers in immunology 2021;12:620238
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Lin L, Chen S, Wang H, Gao B, Kallakury B, Bhuvaneshwar K, Cahn K, Gusev Y, Wang X, Wu Y, Marshall JL, Zhi X, He AR
Theranostics 2021;11(9):4232-4250
Theranostics 2021;11(9):4232-4250
Cobalt induces neurodegenerative damages through Pin1 inactivation in mice and human neuroglioma cells.
Zheng F, Li Y, Zhang F, Sun Y, Zheng C, Luo Z, Wang YL, Aschner M, Zheng H, Lin L, Cai P, Shao W, Guo Z, Zheng M, Zhou XZ, Lu KP, Wu S, Li H
Journal of hazardous materials 2021 Oct 5;419:126378
Journal of hazardous materials 2021 Oct 5;419:126378
Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation.
Häge S, Sonntag E, Svrlanska A, Borst EM, Stilp AC, Horsch D, Müller R, Kropff B, Milbradt J, Stamminger T, Schlötzer-Schrehardt U, Marschall M
Viruses 2021 Jan 22;13(2)
Viruses 2021 Jan 22;13(2)
Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis.
Nakatsu Y, Yamamotoya T, Okumura M, Ishii T, Kanamoto M, Naito M, Nakanishi M, Aoyama S, Matsunaga Y, Kushiyama A, Sakoda H, Fujishiro M, Ono H, Asano T
Metabolism: clinical and experimental 2021 Feb;115:154459
Metabolism: clinical and experimental 2021 Feb;115:154459
LGR5 induces β-catenin activation and augments tumour progression by activating STAT3 in human intrahepatic cholangiocarcinoma.
Kawasaki K, Kuboki S, Furukawa K, Takayashiki T, Takano S, Ohtsuka M
Liver international : official journal of the International Association for the Study of the Liver 2021 Apr;41(4):865-881
Liver international : official journal of the International Association for the Study of the Liver 2021 Apr;41(4):865-881
Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.
Chen D, Mei Y, Kim N, Lan G, Gan CL, Fan F, Zhang T, Xia Y, Wang L, Lin C, Ke F, Zhou XZ, Lu KP, Lee TH
Journal of pineal research 2020 Sep;69(2):e12665
Journal of pineal research 2020 Sep;69(2):e12665
Halo and Pseudohalo Gold(I)-NHC Complexes Derived from 4,5-Diarylimidazoles with Excellent In Vitro and In Vivo Anticancer Activities Against HCC.
Bian M, Fan R, Jiang G, Wang Y, Lu Y, Liu W
Journal of medicinal chemistry 2020 Sep 10;63(17):9197-9211
Journal of medicinal chemistry 2020 Sep 10;63(17):9197-9211
Deficiency of microRNA-628-5p promotes the progression of gastric cancer by upregulating PIN1.
Chen Y, Wu Y, Yu S, Yang H, Wang X, Zhang Y, Zhu S, Jie M, Liu C, Li X, Zhou Y, Yang S, Yang Y
Cell death & disease 2020 Jul 23;11(7):559
Cell death & disease 2020 Jul 23;11(7):559
The peptidyl-prolyl cis/trans isomerase Pin1 interacts with three early regulatory proteins of human cytomegalovirus.
Schütz M, Thomas M, Wangen C, Wagner S, Rauschert L, Errerd T, Kießling M, Sticht H, Milbradt J, Marschall M
Virus research 2020 Aug;285:198023
Virus research 2020 Aug;285:198023
TGF-β1-PML SUMOylation-peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis.
Wu D, Huang D, Li LL, Ni P, Li XX, Wang B, Han YN, Shao XQ, Zhao D, Chu WF, Li BY
Journal of cellular physiology 2019 May;234(5):6263-6273
Journal of cellular physiology 2019 May;234(5):6263-6273
Cellular glucose metabolism is essential for the reduction of cell-impermeable water-soluble tetrazolium (WST) dyes.
Xie L, Dai Z, Pang C, Lin D, Zheng M
International journal of biological sciences 2018;14(11):1535-1544
International journal of biological sciences 2018;14(11):1535-1544
Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway.
Wang S, Liao L, Wang M, Zhou H, Huang Y, Wang Z, Chen D, Ji D, Xia X, Wang Y, Liu F, Huang J, Xiong K
Frontiers in cellular neuroscience 2017;11:425
Frontiers in cellular neuroscience 2017;11:425
The Essential Role of Pin1 via NF-κB Signaling in Vascular Inflammation and Atherosclerosis in ApoE-/- Mice.
Liu M, Yu P, Jiang H, Yang X, Zhao J, Zou Y, Ge J
International journal of molecular sciences 2017 Mar 16;18(3)
International journal of molecular sciences 2017 Mar 16;18(3)
Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.
Tang L, Zhang Y, Chen G, Xiong Y, Wang X, Zhu B
Neurochemical research 2017 Apr;42(4):1211-1218
Neurochemical research 2017 Apr;42(4):1211-1218
Pin1 promotes GR transactivation by enhancing recruitment to target genes.
Poolman TM, Farrow SN, Matthews L, Loudon AS, Ray DW
Nucleic acids research 2013 Oct;41(18):8515-25
Nucleic acids research 2013 Oct;41(18):8515-25
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10495-1-AP(PIN1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PIN1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PIN1. This antibody recognizes human,mouse,rat antigen. The PIN1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
