ABIN493364

antibody from antibodies-online

Targeting: PIN1 dod

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

ABIN493364

Provider

antibodies-online

Product name

anti-Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 53-73) antibody

Antibody type

Polyclonal

Antigen

Synthetic peptides corresponding to amino acids 53-73 of Human PIN1Remarks: The PIN1-selective antibodies were generated against unique antigenic peptidesequences form rat/mouse and human PIN protein, these peptide sequences were notfound inany other protein listed in the gene bank.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

0.1 mg

Concentration

0.56-0.62 mg/ml (lot. specific)

Storage

Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

References

Submitted references

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.

Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP
The Journal of clinical investigation 2008 May;118(5):1877-89

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Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity.

Pani E, Menigatti M, Schubert S, Hess D, Gerrits B, Klempnauer KH, Ferrari S
Biochimica et biophysica acta 2008 Jun;1783(6):1121-8

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Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.

Barone MC, Desouza LA, Freeman RS
Journal of neurochemistry 2008 Jul;106(2):734-45

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Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint.

Campaner S, Kaldis P, Izraeli S, Kirsch IR
Molecular and cellular biology 2005 Aug;25(15):6660-72

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Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.

Fujimori F, Takahashi K, Uchida C, Uchida T
Biochemical and biophysical research communications 1999 Nov 30;265(3):658-63