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- References [10]
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- Western blot [1]
- Immunoprecipitation [2]
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- Product number
- 19126-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19126-1-AP, RRID:AB_10641050
- Product name
- Polycystin 2 antibody
- Antibody type
- Polyclonal
- Description
- Polycystin 2 antibody (Cat. #19126-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, Canine and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips.
Blockage of polycystin-2 alleviates myocardial ischemia/reperfusion injury by inhibiting autophagy through the Ca(2+)/Akt/Beclin 1 pathway.
Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney disease.
TRPP2 is located in the primary cilia of human non-pigmented ciliary epithelial cells.
Excess microtubule and F-actin formation mediates shortening and loss of primary cilia in response to a hyperosmotic milieu.
Pkd2 Deficiency in Embryonic Aqp2 + Progenitor Cells Is Sufficient to Cause Severe Polycystic Kidney Disease.
Shear stress induces autophagy in Schlemm's canal cells via primary cilia-mediated SMAD2/3 signaling pathway.
The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries.
iTRAQ-Based Proteomic Analysis of Neonatal Kidney from Offspring of Protein Restricted Rats Reveals Abnormalities in Intraflagellar Transport Proteins.
Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells.
Li J, Peng W, Kwok M, Ding H, Zhuo D, Gurung B, Lakhani IR, Yu H, Poon EN, Li RA, Yao X
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
Blockage of polycystin-2 alleviates myocardial ischemia/reperfusion injury by inhibiting autophagy through the Ca(2+)/Akt/Beclin 1 pathway.
Qin XD, Liang JF, Gan LY, Peng KS, Huang XH, Li XT, Chen JL, Li W, Zhang L, Jian J, Lu J
Biochimica et biophysica acta. Molecular cell research 2025 Feb;1872(2):119892
Biochimica et biophysica acta. Molecular cell research 2025 Feb;1872(2):119892
Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney disease.
Itabashi T, Hosoba K, Morita T, Kimura S, Yamaoka K, Hirosawa M, Kobayashi D, Kishi H, Kume K, Itoh H, Kawakami H, Hashimoto K, Yamamoto T, Miyamoto T
Life science alliance 2025 Apr;8(4)
Life science alliance 2025 Apr;8(4)
TRPP2 is located in the primary cilia of human non-pigmented ciliary epithelial cells.
Zheng W, Ziemssen F, Suesskind D, Voykov B, Schnichels S
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2024 Jan;262(1):93-102
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2024 Jan;262(1):93-102
Excess microtubule and F-actin formation mediates shortening and loss of primary cilia in response to a hyperosmotic milieu.
Otani H, Nakazato R, Koike K, Ohta K, Ikegami K
Journal of cell science 2024 Aug 15;137(16)
Journal of cell science 2024 Aug 15;137(16)
Pkd2 Deficiency in Embryonic Aqp2 + Progenitor Cells Is Sufficient to Cause Severe Polycystic Kidney Disease.
Tsilosani A, Gao C, Chen E, Lightle AR, Shehzad S, Sharma M, Tran PV, Bates CM, Wallace DP, Zhang W
Journal of the American Society of Nephrology : JASN 2024 Apr 1;35(4):398-409
Journal of the American Society of Nephrology : JASN 2024 Apr 1;35(4):398-409
Shear stress induces autophagy in Schlemm's canal cells via primary cilia-mediated SMAD2/3 signaling pathway.
Shim MS, Dixon A, Nettesheim A, Perkumas KM, Stamer WD, Sun Y, Liton PB
Autophagy reports 2023;2(1)
Autophagy reports 2023;2(1)
The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries.
Hou X, Huang M, Zeng X, Zhang Y, Sun A, Wu Q, Zhu L, Zhao H, Liao Y
Frontiers in molecular biosciences 2021;8:698975
Frontiers in molecular biosciences 2021;8:698975
iTRAQ-Based Proteomic Analysis of Neonatal Kidney from Offspring of Protein Restricted Rats Reveals Abnormalities in Intraflagellar Transport Proteins.
Liu X, Wang J, Gao L, Liu H, Liu C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):185-199
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):185-199
Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells.
Ren JG, Xia HF, Yang JG, Zhu JY, Zhang W, Chen G, Zhao JH, Sun YF, Zhao YF
Human pathology 2017 Jul;65:231-238
Human pathology 2017 Jul;65:231-238
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human kidney tissue were subjected to SDS PAGE followed by western blot with 19126-1-AP(PKD2 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP result of anti-PKD2 (19126-1-AP for IP and Detection) with HeLa cell lysate.
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Polycystin 2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Polycystin 2. This antibody recognizes human,mouse,rat antigen. The Polycystin 2 antibody has been validated for the following applications: ELISA, WB, IP analysis.
