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- Antigen structure
- References [10]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 16476-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16476-1-AP, RRID:AB_2265134
- Product name
- JMJD6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated JMJD6 antibody (Cat. #16476-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ARGLU1 enhances promoter-proximal pausing of RNA polymerase II and stimulates DNA damage repair.
Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both In Vitro and In Vivo.
Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progression.
JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit.
Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape.
JMJD6-BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells.
c-Jun-mediated JMJD6 restoration enhances resistance of liver cancer to radiotherapy through the IL-4-activated ERK pathway.
Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer.
JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination.
JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.
Bachus S, Akkerman N, Fulham L, Graves D, Helwer R, Rempel J, Pelka P
Nucleic acids research 2024 Jun 10;52(10):5658-5675
Nucleic acids research 2024 Jun 10;52(10):5658-5675
Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both In Vitro and In Vivo.
Huang QX, Fan DM, Zheng ZZ, Ran T, Bai A, Xiao RQ, Hu GS, Liu W
Journal of medicinal chemistry 2024 Apr 25;67(8):6658-6672
Journal of medicinal chemistry 2024 Apr 25;67(8):6658-6672
Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progression.
Guang Z, Min Z, Jun-Tan L, Tian-Xu D, Xiang G
Frontiers in immunology 2023;14:1077003
Frontiers in immunology 2023;14:1077003
JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit.
Guo Z, Hu YH, Feng GS, Valenzuela Ripoll C, Li ZZ, Cai SD, Wang QQ, Luo WW, Li Q, Liang LY, Wu ZK, Zhang JG, Javaheri A, Wang L, Lu J, Liu PQ
Acta pharmacologica Sinica 2023 Sep;44(9):1777-1789
Acta pharmacologica Sinica 2023 Sep;44(9):1777-1789
Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape.
Cao Y, Wu J, Hu Y, Chai Y, Song J, Duan J, Zhang S, Xu X
Cell reports 2023 Oct 31;42(10):113262
Cell reports 2023 Oct 31;42(10):113262
JMJD6-BRD4 complex stimulates lncRNA HOTAIR transcription by binding to the promoter region of HOTAIR and induces radioresistance in liver cancer stem cells.
Pei R, Zhao L, Ding Y, Su Z, Li D, Zhu S, Xu L, Zhao W, Zhou W
Journal of translational medicine 2023 Oct 25;21(1):752
Journal of translational medicine 2023 Oct 25;21(1):752
c-Jun-mediated JMJD6 restoration enhances resistance of liver cancer to radiotherapy through the IL-4-activated ERK pathway.
Liu Y, Sui A, Sun J, Wu Y, Liu F, Yang Y
Cell biology international 2023 Aug;47(8):1392-1405
Cell biology international 2023 Aug;47(8):1392-1405
Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer.
Li J, Liu T, Song Y, Wang M, Liu L, Zhu H, Li Q, Lin J, Jiang H, Chen K, Zhao K, Wang M, Zhou H, Lin H, Luo C
Journal of medicinal chemistry 2022 Aug 25;65(16):11034-11057
Journal of medicinal chemistry 2022 Aug 25;65(16):11034-11057
JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination.
Zhang W, Wang Q, Yang F, Zhu Z, Duan Y, Yang Y, Cao W, Zhang K, Ma J, Liu X, Zheng H
PLoS pathogens 2021 Mar;17(3):e1009366
PLoS pathogens 2021 Mar;17(3):e1009366
JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex.
Gao WW, Xiao RQ, Zhang WJ, Hu YR, Peng BL, Li WJ, He YH, Shen HF, Ding JC, Huang QX, Ye TY, Li Y, Liu ZY, Ding R, Rosenfeld MG, Liu W
Molecular cell 2018 Apr 19;70(2):340-357.e8
Molecular cell 2018 Apr 19;70(2):340-357.e8
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 16476-1-AP(JMJD6 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 16476-1-AP(JMJD6 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The JMJD6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human JMJD6. This antibody recognizes human,mouse,rat antigen. The JMJD6 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
