Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 14326-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14326-1-AP, RRID:AB_2179092
- Product name
- RHOB antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RHOB antibody (Cat. #14326-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Fluvastatin prevents lung metastasis in triple-negative breast cancer by triggering autophagy via the RhoB/PI3K/mTOR pathway.
Hepatocellular Carcinoma Cell-Derived Exosomal miR-21-5p Induces Macrophage M2 Polarization by Targeting RhoB.
MiR-21 Is Induced by Hypoxia and Down-Regulates RHOB in Prostate Cancer.
Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer.
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
The association of transcription factor Prox1 with the proliferation, migration, and invasion of lung cancer.
GTPBP2 positively regulates the invasion, migration and proliferation of non-small cell lung cancer.
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases.
Androgen receptor activation decreases proliferation in thyroid cancer cells.
TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling.
Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation.
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
RALY may cause an aggressive biological behavior and a dismal prognosis in non-small-cell lung cancer.
Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB.
ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.
RhoB Acts as a Tumor Suppressor That Inhibits Malignancy of Clear Cell Renal Cell Carcinoma.
MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells.
Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway.
Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells.
Xu WH, Zhang T, Zhou Y, Mao Y
Experimental cell research 2024 Feb 1;435(1):113893
Experimental cell research 2024 Feb 1;435(1):113893
Hepatocellular Carcinoma Cell-Derived Exosomal miR-21-5p Induces Macrophage M2 Polarization by Targeting RhoB.
Yu H, Pan J, Zheng S, Cai D, Luo A, Xia Z, Huang J
International journal of molecular sciences 2023 Feb 27;24(5)
International journal of molecular sciences 2023 Feb 27;24(5)
MiR-21 Is Induced by Hypoxia and Down-Regulates RHOB in Prostate Cancer.
Angel CZ, Stafford MYC, McNally CJ, Nesbitt H, McKenna DJ
Cancers 2023 Feb 17;15(4)
Cancers 2023 Feb 17;15(4)
Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer.
Gu J, Huang W, Wang X, Zhang J, Tao T, Zheng Y, Liu S, Yang J, Chen ZS, Cai CY, Li J, Wang H, Fan Y
Molecular cancer 2022 May 10;21(1):112
Molecular cancer 2022 May 10;21(1):112
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
Peng T, He Y, Wang T, Yu J, Ma X, Zhou Z, Sheng Y, Li L, Peng H, Li S, Zou J, Yuan Y, Zhao Y, Shi H, Li F, Liu W, Hu K, Lu X, Zhang G, Wang F
Journal of medicinal chemistry 2022 Aug 25;65(16):11010-11033
Journal of medicinal chemistry 2022 Aug 25;65(16):11010-11033
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
Feng F, Zhao Z, Zhou Y, Cheng Y, Wu X, Heng X
Frontiers in molecular biosciences 2021;8:705008
Frontiers in molecular biosciences 2021;8:705008
The association of transcription factor Prox1 with the proliferation, migration, and invasion of lung cancer.
Hao X, Luo W, Qiu X
Open life sciences 2021;16(1):602-610
Open life sciences 2021;16(1):602-610
GTPBP2 positively regulates the invasion, migration and proliferation of non-small cell lung cancer.
Jie L, Cong L, Conghui W, Ying G
Journal of Cancer 2021;12(13):3819-3826
Journal of Cancer 2021;12(13):3819-3826
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases.
Ahmad Mokhtar AMB, Ahmed SBM, Darling NJ, Harris M, Mott HR, Owen D
Biochemistry 2021 May 18;60(19):1533-1551
Biochemistry 2021 May 18;60(19):1533-1551
Androgen receptor activation decreases proliferation in thyroid cancer cells.
Jones ME, O'Connell TJ, Zhao H, Darzynkiewicz Z, Gupta A, Buchsbaum J, Shin E, Iacob C, Suslina N, Moscatello A, Schantz S, Tiwari R, Geliebter J
Journal of cellular biochemistry 2021 Apr 20;
Journal of cellular biochemistry 2021 Apr 20;
TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling.
Zhang X, Luo Y, Li Q
OncoTargets and therapy 2020;13:5819-5830
OncoTargets and therapy 2020;13:5819-5830
Proteomic Profiling of Small Extracellular Vesicles Secreted by Human Pancreatic Cancer Cells Implicated in Cellular Transformation.
Servage KA, Stefanius K, Gray HF, Orth K
Scientific reports 2020 May 7;10(1):7713
Scientific reports 2020 May 7;10(1):7713
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Li M, Min W, Wang J, Wang L, Li Y, Zhou N, Yang Z, Qian Q
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
RALY may cause an aggressive biological behavior and a dismal prognosis in non-small-cell lung cancer.
Song G, Guo G, Du T, Li X, Wang J, Yan Y, Zhao Y
Experimental cell research 2020 Apr 15;389(2):111884
Experimental cell research 2020 Apr 15;389(2):111884
Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
Ma Q, Gao Y, Xu P, Li K, Xu X, Gao J, Qi Y, Xu J, Yang Y, Song W, He X, Liu S, Yuan X, Yin W, He Y, Pan W, Wei L, Zhang J
BioMed research international 2019;2019:3235021
BioMed research international 2019;2019:3235021
MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB.
Niu S, Ma X, Zhang Y, Liu YN, Chen X, Gong H, Yao Y, Liu K, Zhang X
PloS one 2018;13(2):e0192790
PloS one 2018;13(2):e0192790
ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.
Liu M, Zeng T, Zhang X, Liu C, Wu Z, Yao L, Xie C, Xia H, Lin Q, Xie L, Zhou D, Deng X, Chan HL, Zhao TJ, Wang HR
Nature communications 2018 Oct 8;9(1):4139
Nature communications 2018 Oct 8;9(1):4139
RhoB Acts as a Tumor Suppressor That Inhibits Malignancy of Clear Cell Renal Cell Carcinoma.
Chen W, Niu S, Ma X, Zhang P, Gao Y, Fan Y, Pang H, Gong H, Shen D, Gu L, Zhang Y, Zhang X
PloS one 2016;11(7):e0157599
PloS one 2016;11(7):e0157599
MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells.
Zeng Y, Zhang X, Kang K, Chen J, Wu Z, Huang J, Lu W, Chen Y, Zhang J, Wang Z, Zhai Y, Qu J, Ramchandran R, Raj JU, Wang J, Gou D
Scientific reports 2016 Apr 28;6:24900
Scientific reports 2016 Apr 28;6:24900
Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway.
Gao Y, Song C, Hui L, Li CY, Wang J, Tian Y, Han X, Chen Y, Tian DL, Qiu X, Wang E
PloS one 2014;9(1):e85377
PloS one 2014;9(1):e85377
Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells.
Zhang C, Elkahloun AG, Liao H, Delaney S, Saber B, Morrow B, Prendergast GC, Hollander MC, Gills JJ, Dennis PA
Molecular cancer therapeutics 2011 Jul;10(7):1137-48
Molecular cancer therapeutics 2011 Jul;10(7):1137-48
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 14326-1-AP(RHOB antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using RHOB antibody 14326-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line