CABT-L1568

antibody from Creative Diagnostics

Targeting: RHOB ARH6, ARHB, MST081, RHOH6

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

CABT-L1568

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human RhoB monoclonal antibody, clone 20I2M6

Antibody type

Monoclonal

Description

Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor- deletion of RhoB causes tumor formation.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

20I2M6

Concentration

0.5 mg/ml

Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.