Antibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11947-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11947-1-AP, RRID:AB_2269388
- Product name
- RAB5A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RAB5A antibody (Cat. #11947-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport.
Cell death induced by nicotine in human neuroblastoma SH-SY5Y cells is mainly attributed to cytoplasmic vacuolation originating from the trans-Golgi network.
Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4.
miR-451a suppresses the proliferation and migration of high-grade serous ovarian cancer by targeting RAB5A through the Ras/Raf/MEK/ERK pathway.
Molecular basis for the different PCV2 susceptibility of T-lymphoblasts in Landrace and Piétrain pigs.
Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy.
Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.
Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15.
25-hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.
Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions.
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging.
Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease.
Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids.
Porcine Circovirus Type 3 Enters Into PK15 Cells Through Clathrin- and Dynamin-2-Mediated Endocytosis in a Rab5/Rab7 and pH-Dependent Fashion.
Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.
Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor.
Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth.
Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion.
Atorvastatin Targets the Islet Mevalonate Pathway to Dysregulate mTOR Signaling and Reduce β-Cell Functional Mass.
The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization.
Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.
A crucial role for Arf6 in the response of commissural axons to Slit.
Rab5a suppresses autophagy to promote drug resistance in cancer cells.
Reduced graphene oxide triggered epithelial-mesenchymal transition in A549 cells.
Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells.
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity.
Rab5a is overexpressed in oral cancer and promotes invasion through ERK/MMP signaling.
Expression of Rab5a correlates with tumor progression in pancreatic carcinoma.
Identification of TMEM230 mutations in familial Parkinson's disease.
MicroRNA-130a inhibits cell proliferation, invasion and migration in human breast cancer by targeting the RAB5A.
Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections.
Sun C, Zhang Y, Wang Z, Chen J, Zhang J, Gu Y
International journal of biological macromolecules 2024 Mar;262(Pt 2):130055
International journal of biological macromolecules 2024 Mar;262(Pt 2):130055
Cell death induced by nicotine in human neuroblastoma SH-SY5Y cells is mainly attributed to cytoplasmic vacuolation originating from the trans-Golgi network.
Li J, Wang H, Chen H, Li X, Liu Y, Hou H, Hu Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114431
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Mar;185:114431
Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4.
Zhou BW, Zhang WJ, Zhang FL, Yang X, Ding YQ, Yao ZW, Yan ZZ, Zhao BC, Chen XD, Li C, Liu KX
Journal of translational medicine 2024 Mar 28;22(1):316
Journal of translational medicine 2024 Mar 28;22(1):316
miR-451a suppresses the proliferation and migration of high-grade serous ovarian cancer by targeting RAB5A through the Ras/Raf/MEK/ERK pathway.
Liu S, Wang K, Zhao Z, Pang Y, Liu F, Wang P, Wang Z, Yang X
The journal of gene medicine 2024 Jan;26(1):e3649
The journal of gene medicine 2024 Jan;26(1):e3649
Molecular basis for the different PCV2 susceptibility of T-lymphoblasts in Landrace and Piétrain pigs.
Ouyang Y, Nauwynck HJ
Veterinary research 2024 Feb 19;55(1):22
Veterinary research 2024 Feb 19;55(1):22
Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy.
Sun Y, Zheng H, Qian L, Liu Y, Zhu D, Xu Z, Chang W, Xu J, Wang L, Sun B, Gu L, Yuan H, Lou H
JACS Au 2023 Oct 23;3(10):2749-2762
JACS Au 2023 Oct 23;3(10):2749-2762
Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.
Biswas S, Mandal G, Anadon CM, Chaurio RA, Lopez-Bailon LU, Nagy MZ, Mine JA, Hänggi K, Sprenger KB, Innamarato P, Harro CM, Powers JJ, Johnson J, Fang B, Eysha M, Nan X, Li R, Perez BA, Curiel TJ, Yu X, Rodriguez PC, Conejo-Garcia JR
Immunity 2023 Nov 14;56(11):2570-2583.e6
Immunity 2023 Nov 14;56(11):2570-2583.e6
Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15.
Jain R, Geoghegan G, Davidson J, Nesbitt DJ, Abe A, Chao X, James I, Cavanagh A, Michorowska S, Verma R, Scheuler K, Hinkovska-Galcheva V, Shishkova E, Ding WX, Coon JJ, Shayman JA, Simcox JA
bioRxiv : the preprint server for biology 2023 Nov 10;
bioRxiv : the preprint server for biology 2023 Nov 10;
25-hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.
Zhang L, Yi Y, Wang T, Song M, Guo K, Zhang Y
Veterinary microbiology 2023 Mar;278:109668
Veterinary microbiology 2023 Mar;278:109668
Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions.
Chu Q, Wang J, Du Y, Zhou T, Shi A, Xiong J, Ji WK, Deng L
Cell death and differentiation 2023 Jan;30(1):94-110
Cell death and differentiation 2023 Jan;30(1):94-110
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Tuck BJ, Miller LVC, Katsinelos T, Smith AE, Wilson EL, Keeling S, Cheng S, Vaysburd MJ, Knox C, Tredgett L, Metzakopian E, James LC, McEwan WA
Cell reports 2022 May 3;39(5):110776
Cell reports 2022 May 3;39(5):110776
RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging.
Jin X, Wang K, Wang L, Liu W, Zhang C, Qiu Y, Liu W, Zhang H, Zhang D, Yang Z, Wu T, Li J
Autophagy 2022 Mar;18(3):643-660
Autophagy 2022 Mar;18(3):643-660
Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease.
Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N
iScience 2022 Mar 18;25(3):103869
iScience 2022 Mar 18;25(3):103869
Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids.
Yang QY, Yang YL, Tang YX, Qin P, Wang G, Xie JY, Chen SX, Ding C, Huang YW, Zhu SJ
PLoS pathogens 2022 Jun;18(6):e1010620
PLoS pathogens 2022 Jun;18(6):e1010620
Porcine Circovirus Type 3 Enters Into PK15 Cells Through Clathrin- and Dynamin-2-Mediated Endocytosis in a Rab5/Rab7 and pH-Dependent Fashion.
Shi R, Hou L, Wei L, Quan R, Zhou B, Jiang H, Wang J, Zhu S, Song J, Wang D, Liu J
Frontiers in microbiology 2021;12:636307
Frontiers in microbiology 2021;12:636307
Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.
Wang D, Ye Z, Wei W, Yu J, Huang L, Zhang H, Yue J
eLife 2021 Nov 19;10
eLife 2021 Nov 19;10
Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor.
Ponsford AH, Ryan TA, Raimondi A, Cocucci E, Wycislo SA, Fröhlich F, Swan LE, Stagi M
Autophagy 2021 Jun;17(6):1500-1518
Autophagy 2021 Jun;17(6):1500-1518
Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth.
Zhang J, Sun Y, Zhong LY, Yu NN, Ouyang L, Fang RD, Wang Y, He QY
Computational and structural biotechnology journal 2020;18:3936-3946
Computational and structural biotechnology journal 2020;18:3936-3946
Interferon-Induced Transmembrane Protein 3 Is a Virus-Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion.
Zhang A, Duan H, Zhao H, Liao H, Du Y, Li L, Jiang D, Wan B, Wu Y, Ji P, Zhou EM, Zhang G
Journal of virology 2020 Nov 23;94(24)
Journal of virology 2020 Nov 23;94(24)
Atorvastatin Targets the Islet Mevalonate Pathway to Dysregulate mTOR Signaling and Reduce β-Cell Functional Mass.
Shen L, Gu Y, Qiu Y, Cheng T, Nie A, Cui C, Fu C, Li T, Li X, Fu L, Wang Y, Ni Q, Wang Q, Wang W, Feng B
Diabetes 2020 Jan;69(1):48-59
Diabetes 2020 Jan;69(1):48-59
The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization.
Bai B, Wang XF, Zhang M, Na L, Zhang X, Zhang H, Yang Z, Wang X
Viruses 2020 Feb 16;12(2)
Viruses 2020 Feb 16;12(2)
Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.
Essandoh K, Deng S, Wang X, Jiang M, Mu X, Peng J, Li Y, Peng T, Wagner KU, Rubinstein J, Fan GC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7451-7466
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7451-7466
A crucial role for Arf6 in the response of commissural axons to Slit.
Kinoshita-Kawada M, Hasegawa H, Hongu T, Yanagi S, Kanaho Y, Masai I, Mishima T, Chen X, Tsuboi Y, Rao Y, Yuasa-Kawada J, Wu JY
Development (Cambridge, England) 2019 Feb 4;146(3)
Development (Cambridge, England) 2019 Feb 4;146(3)
Rab5a suppresses autophagy to promote drug resistance in cancer cells.
Xu W, Shi Q, Qian X, Zhou B, Xu J, Zhu L, Feng L, Jin H, Wang X
American journal of translational research 2018;10(4):1229-1236
American journal of translational research 2018;10(4):1229-1236
Reduced graphene oxide triggered epithelial-mesenchymal transition in A549 cells.
Liao Y, Wang W, Huang X, Sun Y, Tian S, Cai P
Scientific reports 2018 Oct 12;8(1):15188
Scientific reports 2018 Oct 12;8(1):15188
Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells.
Zhu K, Li S, Liu J, Hong Y, Chen ZJ, Du Y
Reproduction (Cambridge, England) 2018 Jun;155(6):505-514
Reproduction (Cambridge, England) 2018 Jun;155(6):505-514
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Yu Z, Ma J, Li X, Liu Y, Li M, Wang L, Zhao M, He H, Zhang Y, Rao Q, Zhao D, Wang Y, Fan L, Li P, Liu Y, Liu F, Zhang F, Ye J, Yan Q, Guo S, Wang Z
Scientific reports 2018 Jul 2;8(1):9972
Scientific reports 2018 Jul 2;8(1):9972
Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity.
Yao Z, Qiao Y, Li X, Chen J, Ding J, Bai L, Shen F, Shi B, Liu J, Peng L, Li J, Yuan Z
Journal of virology 2018 Dec 15;92(24)
Journal of virology 2018 Dec 15;92(24)
Rab5a is overexpressed in oral cancer and promotes invasion through ERK/MMP signaling.
Zhang D, Lu C, Ai H
Molecular medicine reports 2017 Oct;16(4):4569-4576
Molecular medicine reports 2017 Oct;16(4):4569-4576
Expression of Rab5a correlates with tumor progression in pancreatic carcinoma.
Li Y, Sun X, Ji D, Kong X, Liu D, Zhao Z, Yan J, Chen S
Virchows Archiv : an international journal of pathology 2017 May;470(5):527-536
Virchows Archiv : an international journal of pathology 2017 May;470(5):527-536
Identification of TMEM230 mutations in familial Parkinson's disease.
Deng HX, Shi Y, Yang Y, Ahmeti KB, Miller N, Huang C, Cheng L, Zhai H, Deng S, Nuytemans K, Corbett NJ, Kim MJ, Deng H, Tang B, Yang Z, Xu Y, Chan P, Huang B, Gao XP, Song Z, Liu Z, Fecto F, Siddique N, Foroud T, Jankovic J, Ghetti B, Nicholson DA, Krainc D, Melen O, Vance JM, Pericak-Vance MA, Ma YC, Rajput AH, Siddique T
Nature genetics 2016 Jul;48(7):733-9
Nature genetics 2016 Jul;48(7):733-9
MicroRNA-130a inhibits cell proliferation, invasion and migration in human breast cancer by targeting the RAB5A.
Pan Y, Wang R, Zhang F, Chen Y, Lv Q, Long G, Yang K
International journal of clinical and experimental pathology 2015;8(1):384-93
International journal of clinical and experimental pathology 2015;8(1):384-93
Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections.
Wu KY, He M, Hou QQ, Sheng AL, Yuan L, Liu F, Liu WW, Li G, Jiang XY, Luo ZG
Science signaling 2014 Aug 26;7(340):ra81
Science signaling 2014 Aug 26;7(340):ra81
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 11947-1-AP(RAB5A antibody) at dilution of 1:500
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat brain tissue were subjected to SDS PAGE followed by western blot with 11947-1-AP( RAB5A Antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RAB5A antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RAB5A. This antibody recognizes human,mouse,rat antigen. The RAB5A antibody has been validated for the following applications: ELISA, IHC, WB analysis.