625002

LCP2 antibody from BioLegend
SLP-76, SLP76
Western blot
Data presented on provider website
Immunoprecipitation
Recommended by provider
Flow cytometry
Recommended by provider

Antibody data

Product number
625002
Provider
BioLegend
Proper citation
BioLegend Cat#625002, RRID:AB_2136888
Product name
Purified anti-SLP-76
Provider product page
BioLegend - 625002
Antibody type
Monoclonal
Antigen
amino acids 216-434 of human SLP-76
Description
SLP-76 is a human Src homology domain-containing leukocyte protein. This cytoplasmic adaptor phosphoprotein contains both SH2 and SAM domains and is involved in B and T cell receptor signaling. The amino terminus of this protein contains three 17 amino acid repeats with conserved tyrosine and acidic residues (DYE(S/P)P) as well as a proline rich region and is known to associate with many proteins involved in T and B cell signaling including Grb2, LAT, Vav1, SLAP-130, SHP-1, and phospholipase C gamma 2. SLP-76 can be phosphorylated on multiple tyrosine residues by the upstream kinases ZAP-70 and Lck. SLP-76 phosphorylation plays an important role in T cell-mediated IL-2 production by allowing phosphorylated Vav to bind; this complex (SLP-76/Vav) stimulates NF-AT and IL-2 gene activation after TCR engagement. Overexpression of SLP-76 has been shown to result in enhanced IL-2 transcription after TCR signaling. The H76 monoclonal antibody recognizes human SLP-76 and has been shown to be useful for Western blotting.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
200 µl
Storage
Upon receipt, store frozen at -20°C.
Provider Type Product Number
- No reagents -