66498-1-Ig

antibody from Proteintech Group

Targeting: TRAF6 RNF85

Provider product page for 66498-1-Ig

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Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
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Product number: 66498-1-Ig - Provider product page
Provider: Proteintech Group
Product name: TRAF6 antibody
Antibody type: Monoclonal
Description: KD/KO validated TRAF6 antibody (Cat. #66498-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, WB, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1D1E1
Vial size: 20ul, 150ul

TRAF6 protein structure - 66498-1-Ig shown in red.

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RBM14 inhibits the replication of porcine epidemic diarrhea virus by recruiting p62 to degrade nucleocapsid protein through the activation of autophagy and interferon pathway.

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TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination.

Chen YY, Ran XH, Ni RZ, Mu D
The Journal of biological chemistry 2023 May;299(5):104660

MiR-146a-5p delivered by hucMSC extracellular vesicles modulates the inflammatory response to sulfur mustard-induced acute lung injury.

Pei Z, Cen J, Zhang X, Gong C, Sun M, Meng W, Mao G, Wan J, Hu B, He X, Xu Q, Han H, Xiao K
Stem cell research & therapy 2023 May 30;14(1):149

Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.

Zhang L, Ma X, Shi R, Zhang L, Zhao R, Duan R, Qin Y, Gao S, Li X, Duan J, Li J
British journal of pharmacology 2023 Mar;180(5):628-646

Prediction and Verification of Curcumin as a Potential Drug for Inhibition of PDCoV Replication in LLC-PK1 Cells.

Wang X, Wang X, Zhang J, Shan Q, Zhu Y, Xu C, Wang J
International journal of molecular sciences 2023 Mar 20;24(6)

A Novel Prenylflavonoid Icariside I Ameliorates Estrogen Deficiency-Induced Osteoporosis via Simultaneous Regulation of Osteoblast and Osteoclast Differentiation.

Chen C, Wu M, Lei H, Cao Z, Wu F, Song Y, Zhang C, Qin M, Zhang C, Du R, Zhou J, Lu Y, Xie D, Zhang L
ACS pharmacology & translational science 2023 Feb 10;6(2):270-280

N protein of PEDV plays chess game with host proteins by selective autophagy.

Zhai X, Kong N, Zhang Y, Song Y, Qin W, Yang X, Ye C, Ye M, Tong W, Liu C, Zheng H, Yu H, Zhang W, Yang X, Zhang G, Tong G, Shan T
Autophagy 2023 Aug;19(8):2338-2352

PIMT is a novel and potent suppressor of endothelial activation.

Zhang C, Guo ZF, Liu W, Kazama K, Hu L, Sun X, Wang L, Lee H, Lu L, Yang XF, Summer R, Sun J
eLife 2023 Apr 18;12

Sea Cucumber Hydrolysate Alleviates Immunosuppression and Gut Microbiota Imbalance Induced by Cyclophosphamide in Balb/c Mice through the NF-κB Pathway.

Mao J, Li S, Fu R, Wang Y, Meng J, Jin Y, Wu T, Zhang M
Foods (Basel, Switzerland) 2023 Apr 10;12(8)

Effects of Sparassis latifolia neutral polysaccharide on immune activity via TLR4-mediated MyD88-dependent and independent signaling pathways in RAW264.7 macrophages.

Qiao Z, Zhao Y, Wang M, Cao J, Chang M, Yun S, Cheng Y, Cheng F, Feng C
Frontiers in nutrition 2022;9:994971

Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis.

Zhang H, Zuo Y, Zhao H, Zhao H, Wang Y, Zhang X, Zhang J, Wang P, Sun L, Zhang H, Liang H
Frontiers in nutrition 2022;9:989311

Mechanisms of Neuropathic Pain and Pain-Relieving Effects of Exercise Therapy in a Rat Neuropathic Pain Model.

Sumizono M, Yoshizato Y, Yamamoto R, Imai T, Tani A, Nakanishi K, Nakakogawa T, Matsuoka T, Matsuzaki R, Tanaka T, Sakakima H
Journal of pain research 2022;15:1925-1938

Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).

Xu BL, Wang YY, Jiang LL, Liu Z, Liu DR, Zhao H, Li SL, Wang XB
Frontiers in pharmacology 2022;13:1096137

ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability.

Wan P, Yang G, Zhang S, Zhang Y, Jia Y, Che X, Luo Z, Pan P, Li G, Chen X, Zhang Q, Zhang W, Tan Q, Li Y, Wu J
Frontiers in cellular and infection microbiology 2022;12:759077

KLF16 inhibits PEDV replication by activating the type I IFN signaling pathway.

Dong S, Kong N, Shen H, Li Y, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T
Veterinary microbiology 2022 Nov;274:109577

Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis.

Liu J, Li S, Fei X, Nan X, Shen Y, Xiu H, Cormier SA, Lu C, Guo C, Wang S, Cai Z, Wang P
Autophagy 2022 May;18(5):971-989

Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling.

Hu S, Ren S, Cai Y, Liu J, Han Y, Zhao Y, Yang J, Zhou X, Wang X
Cell death and differentiation 2022 Mar;29(3):642-656

The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation.

Wu Y, Teng Y, Zhang C, Pan Y, Zhang Q, Zhu X, Liu N, Su X, Lin J
Journal of nanobiotechnology 2022 Mar 9;20(1):120

Ginsenoside compound K inhibits obesity-induced insulin resistance by regulation of macrophage recruitment and polarization via activating PPARγ.

Xu J, Dong J, Ding H, Wang B, Wang Y, Qiu Z, Yao F
Food & function 2022 Mar 21;13(6):3561-3571

mascRNA promotes macrophage apoptosis, inhibits osteoclast differentiation and attenuates disease progression in a murine model of arthritis.

Wang X, Sun T, Mao X
Biochemical and biophysical research communications 2022 Jun 30;611:151-157

Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.

Wang Z, Liu D, Yan Q, Liu F, Zhan M, Qi S, Fang Q, Yao L, Wang W, Zhang R, Du J, Chen L
Transplantation 2022 Jul 1;106(7):1351-1364

Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease.

Ruganzu JB, Peng X, He Y, Wu X, Zheng Q, Ding B, Lin C, Guo H, Yang Z, Zhang X, Yang W
Molecular immunology 2022 Feb;142:22-36

Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells.

Lei H, Yang L, Xu H, Wang Z, Li X, Liu M, Wu Y
Science China. Life sciences 2022 Aug;65(8):1624-1635

Morchella importuna Flavones Improve Intestinal Integrity in Dextran Sulfate Sodium-Challenged Mice.

Xu Y, Xie L, Tang J, He X, Zhang Z, Chen Y, Zhou J, Gan B, Peng W
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MicroRNA-2187 Modulates the NF-κB and IRF3 Pathway in Teleost Fish by Targeting TRAF6.

Gao W, Chang R, Sun Y, Xu T
Frontiers in immunology 2021;12:647202

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Ding J, Zhang Y, Cai X, Zhang Y, Yan S, Wang J, Zhang S, Yin T, Yang C, Yang J
Theranostics 2021;11(12):5813-5830

Helicobacter pylori infection disturbs the tumor immune microenvironment and is associated with a discrepant prognosis in gastric de novo diffuse large B-cell lymphoma.

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Journal for immunotherapy of cancer 2021 Oct;9(10)

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Liu GJ, Tao T, Zhang XS, Lu Y, Wu LY, Gao YY, Wang H, Dai HB, Zhou Y, Zhuang Z, Hang CH, Li W
Molecular neurobiology 2021 May;58(5):1963-1977

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Journal of neuroinflammation 2021 May 11;18(1):112

Rosavin suppresses osteoclastogenesis in vivo and in vitro by blocking the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways.

Zhang W, Zhang W, Huo L, Chai Y, Liu Z, Ren Z, Yu C
Annals of translational medicine 2021 Mar;9(5):383

Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.

Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y
Cellular & molecular immunology 2021 Jun;18(6):1587-1589

Evolutionary history and functional characterization of Lj-TICAM-a and Lj-TICAM-b formed via lineage-specific tandem duplication in lamprey (Lampetra japonica).

Geng M, Hua Y, Liu Y, Quan J, Hu X, Su P, Li Y, Liu X, Li Q, Zhu T
Genomics 2021 Jul;113(4):2756-2768

Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-κB activation.

Lenoir JJ, Parisien JP, Horvath CM
Cell reports 2021 Dec 28;37(13):110175

Resveratrol affects the expression of uric acid transporter by improving inflammation.

Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)

GPA Peptide-Induced Nur77 Localization at Mitochondria Inhibits Inflammation and Oxidative Stress through Activating Autophagy in the Intestine.

Deng Z, Liu Q, Wang M, Wei HK, Peng J
Oxidative medicine and cellular longevity 2020;2020:4964202

Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.

Zavaczki E, Gáll T, Zarjou A, Hendrik Z, Potor L, Tóth CZ, Méhes G, Gyetvai Á, Agarwal A, Balla G, Balla J
Oxidative medicine and cellular longevity 2020;2020:3721383

MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways.

Liu GJ, Zhang QR, Gao X, Wang H, Tao T, Gao YY, Zhou Y, Chen XX, Li W, Hang CH
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Corilagin Ameliorates Atherosclerosis in Peripheral Artery Disease via the Toll-Like Receptor-4 Signaling Pathway in vitro and in vivo.

Li Y, Wang Y, Chen Y, Wang Y, Zhang S, Liu P, Chen Z, Song P, Luo L, Luo Y, Dang Y, Zhao L
Frontiers in immunology 2020;11:1611

A miR-146a-5p/TRAF6/NF-kB p65 axis regulates pancreatic cancer chemoresistance: functional validation and clinical significance.

Meng Q, Liang C, Hua J, Zhang B, Liu J, Zhang Y, Wei M, Yu X, Xu J, Shi S
Theranostics 2020;10(9):3967-3979

Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder.

Hu J, Wang H, Li X, Liu Y, Mi Y, Kong H, Xi D, Yan W, Luo X, Ning Q, Wang X
Theranostics 2020;10(21):9702-9720

Silencing of LRP1 Exacerbates Inflammatory Response Via TLR4/NF-κB/MAPKs Signaling Pathways in APP/PS1 Transgenic Mice.

He Y, Ruganzu JB, Zheng Q, Wu X, Jin H, Peng X, Ding B, Lin C, Ji S, Ma Y, Yang W
Molecular neurobiology 2020 Sep;57(9):3727-3743

LRP1 knockdown aggravates Aβ(1-42)-stimulated microglial and astrocytic neuroinflammatory responses by modulating TLR4/NF-κB/MAPKs signaling pathways.

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Experimental cell research 2020 Sep 15;394(2):112166

Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.

Guan L, Li C, Zhang Y, Gong J, Wang G, Tian P, Shen N
Life sciences 2020 Sep 1;256:117935

Tanshinone IIA suppresses lipopolysaccharide-induced neuroinflammatory responses through NF-κB/MAPKs signaling pathways in human U87 astrocytoma cells.

Jin H, Peng X, He Y, Ruganzu JB, Yang W
Brain research bulletin 2020 Nov;164:136-145

MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.

Fei Y, Chaulagain A, Wang T, Chen Y, Liu J, Yi M, Wang Y, Huang Y, Lin L, Chen S, Xu W, Tong L, Wu X, Zhao D, Zhang F, Zhao W, Zhong Z
RNA (New York, N.Y.) 2020 Jan;26(1):91-100

Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro.

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Oxidative medicine and cellular longevity 2019;2019:3765898

Mycobacterium tuberculosis Requires Cholesterol Oxidase to Disrupt TLR2 Signalling in Human Macrophages.

Szulc-Kielbik I, Kielbik M, Przygodzka P, Brzostek A, Dziadek J, Klink M
Mediators of inflammation 2019;2019:2373791

Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.

Liu Y, Jiang Q, Liu X, Lin X, Tang Z, Liu C, Zhou J, Zhao M, Li X, Cheng Z, Li L, Xie Y, Liu Z, Fang W
EBioMedicine 2019 Oct;48:386-404

A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis.

Sun S, Li F, Liu Y, Qu H, Wong SW, Zeng L, Yu M, Feng H, Liu H, Han D
Archives of oral biology 2019 May;101:100-107

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells.

Song P, Yang S, Hua H, Zhang H, Kong Q, Wang J, Luo T, Jiang Y
The Journal of biological chemistry 2019 Apr 12;294(15):5945-5955

MicroRNA-146a: A Comprehensive Indicator of Inflammation and Oxidative Stress Status Induced in the Brain of Chronic T2DM Rats.

Xie Y, Chu A, Feng Y, Chen L, Shao Y, Luo Q, Deng X, Wu M, Shi X, Chen Y
Frontiers in pharmacology 2018;9:478

The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.

Yu Q, Liu T, Li S, Feng J, Wu L, Wang W, Chen K, Xia Y, Niu P, Xu L, Wang F, Dai W, Zhou Y, Guo C
Mediators of inflammation 2018;2018:4032484

STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway.

Wang Y, Xu H, Jiao H, Wang S, Xiao Z, Zhao Y, Bi J, Wei W, Liu S, Qiu J, Li T, Liang L, Ye Y, Liao W, Ding Y
Cell death & disease 2018 May 31;9(6):664

Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection.

Fu Y, Zhang L, Zhang F, Tang T, Zhou Q, Feng C, Jin Y, Wu Z
PLoS pathogens 2017 Sep;13(9):e1006611

Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.

Wang B, Zhao H, Zhao L, Zhang Y, Wan Q, Shen Y, Bu X, Wan M, Shen C
Cancer letters 2017 Nov 1;408:60-70

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