10709-1-AP

antibody from Proteintech Group

Targeting: SIX1 DFNA23

Provider product page for 10709-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [28]
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Validations
Western blot [1]

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Product number: 10709-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10709-1-AP, RRID:AB_2189077
Product name: SIX1 antibody
Antibody type: Polyclonal
Description: KD/KO validated SIX1 antibody (Cat. #10709-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SIX1 protein structure - 10709-1-AP shown in red.

Submitted references Novel LncRNA LINC02936 Suppresses Ferroptosis and Promotes Tumor Progression by Interacting with SIX1/CP Axis in Endometrial Cancer.

Zhang Z, Li B, Wang Z, Yang L, Peng J, Wang H, Wang Y, Hong L
International journal of biological sciences 2024;20(4):1356-1374

CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A.

Feng D, Gao J, Liu R, Liu W, Gao T, Yang Y, Zhang D, Yang T, Yin X, Yu H, Huang W, Wang Y
Protein & cell 2024 Oct 1;15(10):744-765

BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation.

Zhang P, Zhang W, Wang X, Li L, Lin Y, Wu N, Mao R, Lin J, Kang M, Ding C
Cancer letters 2024 Jun 1;591:216874

Porcine Kidney Organoids Derived from Naïve-like Embryonic Stem Cells.

Li M, Guo X, Cheng L, Zhang H, Zhou M, Zhang M, Yin Z, Guo T, Zhao L, Liu H, Liang X, Li R
International journal of molecular sciences 2024 Jan 4;25(1)

Cytoplasmatic Localization of Six1 in Male Testis and Spermatogonial Stem Cells.

Qin M, Ma L, Du W, Chen D, Luo G, Liu Z
International journal of stem cells 2024 Aug 30;17(3):298-308

A Novel EYA1 Mutation Causing Alternative RNA Splicing in a Chinese Family With Branchio-Oto Syndrome: Implications for Molecular Diagnosis and Clinical Application.

Chen A, Ling J, Peng X, Liu X, Mao S, Chen Y, Qin M, Zhang S, Bai Y, Song J, Feng Z, Ma L, He D, Mei L, He C, Feng Y
Clinical and experimental otorhinolaryngology 2023 Nov;16(4):342-358

Identity, lineage and fates of a temporally distinct progenitor population in the embryonic olfactory epithelium.

Paronett EM, Bryan CA, Maynard TM, LaMantia AS
Developmental biology 2023 Mar;495:76-91

DNAAF5 promotes hepatocellular carcinoma malignant progression by recruiting USP39 to improve PFKL protein stability.

Liu Y, Wu Q, Sun T, Huang J, Han G, Han H
Frontiers in oncology 2022;12:1032579

Tanshinone IIA inhibits cell growth by suppressing SIX1-induced aerobic glycolysis in non-small cell lung cancer cells.

Qi H, Chen Z, Qin Y, Wang X, Zhang Z, Li Y
Oncology letters 2022 Jun;23(6):184

Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome.

Karpinski BA, Maynard TM, Bryan CA, Yitsege G, Horvath A, Lee NH, Moody SA, LaMantia AS
Disease models & mechanisms 2022 Feb 1;15(2)

Ginsenoside Rh4 Suppresses Metastasis of Gastric Cancer via SIX1-Dependent TGF-β/Smad2/3 Signaling Pathway.

Jiang H, Ma P, Duan Z, Liu Y, Shen S, Mi Y, Fan D
Nutrients 2022 Apr 9;14(8)

SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.

Jin Y, Zhang M, Li M, Zhang H, Zhao L, Qian C, Li S, Zhang H, Gao M, Pan B, Li R, Wan X, Cao C
Frontiers in molecular biosciences 2021;8:725319

Nuclear TEAD4 with SIX1 Overexpression is an Independent Prognostic Marker in the Stage I-III Colorectal Cancer.

Yu T, Song J, Zhou H, Wu T, Liang Z, Du P, Liu CY, Wang G, Cui L, Liu Y
Cancer management and research 2021;13:1581-1589

miR‑106b‑5p targeting SIX1 inhibits TGF‑β1‑induced pulmonary fibrosis and epithelial‑mesenchymal transition in asthma through regulation of E2F1.

Liu S, Chen X, Zhang S, Wang X, Du X, Chen J, Zhou G
International journal of molecular medicine 2021 Mar;47(3)

O-GlcNAcylation of SIX1 enhances its stability and promotes Hepatocellular Carcinoma Proliferation.

Chu Y, Jiang M, Wu N, Xu B, Li W, Liu H, Su S, Shi Y, Liu H, Gao X, Fu X, Chen D, Li X, Wang W, Liang J, Nie Y, Fan D
Theranostics 2020;10(21):9830-9842

Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome.

Motahari Z, Maynard TM, Popratiloff A, Moody SA, LaMantia AS
Human molecular genetics 2020 Nov 4;29(18):3081-3093

miR-489-3p/SIX1 Axis Regulates Melanoma Proliferation and Glycolytic Potential.

Yang X, Zhu X, Yan Z, Li C, Zhao H, Ma L, Zhang D, Liu J, Liu Z, Du N, Ye Q, Xu X
Molecular therapy oncolytics 2020 Mar 27;16:30-40

Muscle progenitor specification and myogenic differentiation are associated with changes in chromatin topology.

Zhang N, Mendieta-Esteban J, Magli A, Lilja KC, Perlingeiro RCR, Marti-Renom MA, Tsirigos A, Dynlacht BD
Nature communications 2020 Dec 4;11(1):6222

Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion syndrome.

Maynard TM, Horvath A, Bernot JP, Karpinski BA, Tavares ALP, Shah A, Zheng Q, Spurr L, Olender J, Moody SA, Fraser CM, LaMantia AS, Lee NH
Human molecular genetics 2020 Apr 15;29(6):1002-1017

Dynamic enhancers control skeletal muscle identity and reprogramming.

Ramachandran K, Senagolage MD, Sommars MA, Futtner CR, Omura Y, Allred AL, Barish GD
PLoS biology 2019 Oct;17(10):e3000467

Six1 is negatively correlated with poor prognosis and reduces 5-fluorouracil sensitivity via attenuating the stemness of hepatocellular carcinoma cells.

Chen K, Wei H, Pan J, Chen Z, Pan D, Gao T, Huang J, Huang M, Ou M, Zhong W
European journal of pharmacology 2019 Oct 15;861:172599

EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma.

Li Z, Qiu R, Qiu X, Tian T
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1856-1869

Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.

Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q
Cancer cell 2018 Mar 12;33(3):368-385.e7

miR-204-5p suppresses hepatocellular cancer proliferation by regulating homeoprotein SIX1 expression.

Chu Y, Jiang M, Du F, Chen D, Ye T, Xu B, Li X, Wang W, Qiu Z, Liu H, Nie Y, Liang J, Fan D
FEBS open bio 2018 Feb;8(2):189-200

The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.

Adrados I, Larrasa-Alonso J, Galarreta A, López-Antona I, Menéndez C, Abad M, Gil J, Moreno-Bueno G, Palmero I
Oncogene 2016 Jul 7;35(27):3485-94

A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.

Karpinski BA, Bryan CA, Paronett EM, Baker JL, Fernandez A, Horvath A, Maynard TM, Moody SA, LaMantia AS
Developmental biology 2016 Jul 15;415(2):228-241

Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.

Liu D, Zhang XX, Wan DY, Xi BX, Ma D, Wang H, Gao QL
Biochemical and biophysical research communications 2014 Apr 4;446(2):549-54

Expression of Six1 and Six4 in mouse taste buds.

Suzuki Y, Ikeda K, Kawakami K
Journal of molecular histology 2010 Oct;41(4-5):205-14

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A2780 cells were subjected to SDS PAGE followed by western blot with 10709-1-AP(SIX1 antibody) at dilution of 1:800
Sample type: cell line