Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 10709-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10709-1-AP, RRID:AB_2189077
- Product name
- SIX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SIX1 antibody (Cat. #10709-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome.
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Nuclear TEAD4 with SIX1 Overexpression is an Independent Prognostic Marker in the Stage I-III Colorectal Cancer.
miR‑106b‑5p targeting SIX1 inhibits TGF‑β1‑induced pulmonary fibrosis and epithelial‑mesenchymal transition in asthma through regulation of E2F1.
O-GlcNAcylation of SIX1 enhances its stability and promotes Hepatocellular Carcinoma Proliferation.
Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome.
miR-489-3p/SIX1 Axis Regulates Melanoma Proliferation and Glycolytic Potential.
Muscle progenitor specification and myogenic differentiation are associated with changes in chromatin topology.
Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion syndrome.
Dynamic enhancers control skeletal muscle identity and reprogramming.
Six1 is negatively correlated with poor prognosis and reduces 5-fluorouracil sensitivity via attenuating the stemness of hepatocellular carcinoma cells.
EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma.
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
miR-204-5p suppresses hepatocellular cancer proliferation by regulating homeoprotein SIX1 expression.
The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.
A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.
Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.
Expression of Six1 and Six4 in mouse taste buds.
Karpinski BA, Maynard TM, Bryan CA, Yitsege G, Horvath A, Lee NH, Moody SA, LaMantia AS
Disease models & mechanisms 2022 Feb 1;15(2)
Disease models & mechanisms 2022 Feb 1;15(2)
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Jin Y, Zhang M, Li M, Zhang H, Zhao L, Qian C, Li S, Zhang H, Gao M, Pan B, Li R, Wan X, Cao C
Frontiers in molecular biosciences 2021;8:725319
Frontiers in molecular biosciences 2021;8:725319
Nuclear TEAD4 with SIX1 Overexpression is an Independent Prognostic Marker in the Stage I-III Colorectal Cancer.
Yu T, Song J, Zhou H, Wu T, Liang Z, Du P, Liu CY, Wang G, Cui L, Liu Y
Cancer management and research 2021;13:1581-1589
Cancer management and research 2021;13:1581-1589
miR‑106b‑5p targeting SIX1 inhibits TGF‑β1‑induced pulmonary fibrosis and epithelial‑mesenchymal transition in asthma through regulation of E2F1.
Liu S, Chen X, Zhang S, Wang X, Du X, Chen J, Zhou G
International journal of molecular medicine 2021 Mar;47(3)
International journal of molecular medicine 2021 Mar;47(3)
O-GlcNAcylation of SIX1 enhances its stability and promotes Hepatocellular Carcinoma Proliferation.
Chu Y, Jiang M, Wu N, Xu B, Li W, Liu H, Su S, Shi Y, Liu H, Gao X, Fu X, Chen D, Li X, Wang W, Liang J, Nie Y, Fan D
Theranostics 2020;10(21):9830-9842
Theranostics 2020;10(21):9830-9842
Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome.
Motahari Z, Maynard TM, Popratiloff A, Moody SA, LaMantia AS
Human molecular genetics 2020 Nov 4;29(18):3081-3093
Human molecular genetics 2020 Nov 4;29(18):3081-3093
miR-489-3p/SIX1 Axis Regulates Melanoma Proliferation and Glycolytic Potential.
Yang X, Zhu X, Yan Z, Li C, Zhao H, Ma L, Zhang D, Liu J, Liu Z, Du N, Ye Q, Xu X
Molecular therapy oncolytics 2020 Mar 27;16:30-40
Molecular therapy oncolytics 2020 Mar 27;16:30-40
Muscle progenitor specification and myogenic differentiation are associated with changes in chromatin topology.
Zhang N, Mendieta-Esteban J, Magli A, Lilja KC, Perlingeiro RCR, Marti-Renom MA, Tsirigos A, Dynlacht BD
Nature communications 2020 Dec 4;11(1):6222
Nature communications 2020 Dec 4;11(1):6222
Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion syndrome.
Maynard TM, Horvath A, Bernot JP, Karpinski BA, Tavares ALP, Shah A, Zheng Q, Spurr L, Olender J, Moody SA, Fraser CM, LaMantia AS, Lee NH
Human molecular genetics 2020 Apr 15;29(6):1002-1017
Human molecular genetics 2020 Apr 15;29(6):1002-1017
Dynamic enhancers control skeletal muscle identity and reprogramming.
Ramachandran K, Senagolage MD, Sommars MA, Futtner CR, Omura Y, Allred AL, Barish GD
PLoS biology 2019 Oct;17(10):e3000467
PLoS biology 2019 Oct;17(10):e3000467
Six1 is negatively correlated with poor prognosis and reduces 5-fluorouracil sensitivity via attenuating the stemness of hepatocellular carcinoma cells.
Chen K, Wei H, Pan J, Chen Z, Pan D, Gao T, Huang J, Huang M, Ou M, Zhong W
European journal of pharmacology 2019 Oct 15;861:172599
European journal of pharmacology 2019 Oct 15;861:172599
EYA4 Promotes Cell Proliferation Through Downregulation of p27Kip1 in Glioma.
Li Z, Qiu R, Qiu X, Tian T
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1856-1869
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1856-1869
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q
Cancer cell 2018 Mar 12;33(3):368-385.e7
Cancer cell 2018 Mar 12;33(3):368-385.e7
miR-204-5p suppresses hepatocellular cancer proliferation by regulating homeoprotein SIX1 expression.
Chu Y, Jiang M, Du F, Chen D, Ye T, Xu B, Li X, Wang W, Qiu Z, Liu H, Nie Y, Liang J, Fan D
FEBS open bio 2018 Feb;8(2):189-200
FEBS open bio 2018 Feb;8(2):189-200
The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.
Adrados I, Larrasa-Alonso J, Galarreta A, López-Antona I, Menéndez C, Abad M, Gil J, Moreno-Bueno G, Palmero I
Oncogene 2016 Jul 7;35(27):3485-94
Oncogene 2016 Jul 7;35(27):3485-94
A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.
Karpinski BA, Bryan CA, Paronett EM, Baker JL, Fernandez A, Horvath A, Maynard TM, Moody SA, LaMantia AS
Developmental biology 2016 Jul 15;415(2):228-241
Developmental biology 2016 Jul 15;415(2):228-241
Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.
Liu D, Zhang XX, Wan DY, Xi BX, Ma D, Wang H, Gao QL
Biochemical and biophysical research communications 2014 Apr 4;446(2):549-54
Biochemical and biophysical research communications 2014 Apr 4;446(2):549-54
Expression of Six1 and Six4 in mouse taste buds.
Suzuki Y, Ikeda K, Kawakami K
Journal of molecular histology 2010 Oct;41(4-5):205-14
Journal of molecular histology 2010 Oct;41(4-5):205-14
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A2780 cells were subjected to SDS PAGE followed by western blot with 10709-1-AP(SIX1 antibody) at dilution of 1:800
- Sample type
- cell line