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- References [11]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 10021-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10021-1-Ig, RRID:AB_513237
- Product name
- 5 Lipoxygenase antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated 5 Lipoxygenase antibody (Cat. #10021-1-Ig) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis.
ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathway.
The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK/STAT and inhibits pancreatic cancer invasion and metastasis.
Targeting Circulating lncRNA ENST00000538705.1 Relieves Acute Coronary Syndrome via Modulating ALOX15.
Respiratory Syncytial Virus Nonstructural Protein 1 Promotes 5-Lipoxygenase via miR-19a-3p.
Fenofibrate suppresses corneal neovascularization by regulating lipid metabolism through PPARĪ± signaling pathway.
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Comprehensive Analysis of the Tumor Microenvironment and Ferroptosis-Related Genes Predict Prognosis with Ovarian Cancer.
PPARĪ± agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
MK591, a second generation leukotriene biosynthesis inhibitor, prevents invasion and induces apoptosis in the bone-invading C4-2B human prostate cancer cells: implications for the treatment of castration-resistant, bone-metastatic prostate cancer.
Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells.
Chen W, Han L, Yang R, Wang H, Yao S, Deng H, Liu S, Zhou Y, Shen XL
Archives of toxicology 2024 Oct;98(10):3323-3336
Archives of toxicology 2024 Oct;98(10):3323-3336
ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathway.
Chen J, Tang Y, Qin D, Yu X, Tong H, Tang C, Tang Z
Journal of translational medicine 2023 Dec 20;21(1):923
Journal of translational medicine 2023 Dec 20;21(1):923
The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK/STAT and inhibits pancreatic cancer invasion and metastasis.
Hu WM, Liu SQ, Zhu KF, Li W, Yang ZJ, Yang Q, Zhu ZC, Chang J
International immunopharmacology 2023 Aug;121:110505
International immunopharmacology 2023 Aug;121:110505
Targeting Circulating lncRNA ENST00000538705.1 Relieves Acute Coronary Syndrome via Modulating ALOX15.
Chen H, Huang S, Guan F, Han S, Ye F, Li X, You L
Disease markers 2022;2022:8208471
Disease markers 2022;2022:8208471
Respiratory Syncytial Virus Nonstructural Protein 1 Promotes 5-Lipoxygenase via miR-19a-3p.
Zheng M, Fan P, Yang P, Zheng J, Zhao D
Journal of immunology research 2022;2022:4086710
Journal of immunology research 2022;2022:4086710
Fenofibrate suppresses corneal neovascularization by regulating lipid metabolism through PPARĪ± signaling pathway.
Zhou T, Yan K, Zhang Y, Zhu L, Liao Y, Zheng X, Chen Y, Li X, Liu Z, Zhang Z
Frontiers in pharmacology 2022;13:1000254
Frontiers in pharmacology 2022;13:1000254
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Xu F, Zhang J, Zhou X, Hao H
Experimental cell research 2022 Mar 1;412(1):113025
Experimental cell research 2022 Mar 1;412(1):113025
Comprehensive Analysis of the Tumor Microenvironment and Ferroptosis-Related Genes Predict Prognosis with Ovarian Cancer.
Li XX, Xiong L, Wen Y, Zhang ZJ
Frontiers in genetics 2021;12:774400
Frontiers in genetics 2021;12:774400
PPARĪ± agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
MK591, a second generation leukotriene biosynthesis inhibitor, prevents invasion and induces apoptosis in the bone-invading C4-2B human prostate cancer cells: implications for the treatment of castration-resistant, bone-metastatic prostate cancer.
Sarveswaran S, Ghosh R, Morisetty S, Ghosh J
PloS one 2015;10(4):e0122805
PloS one 2015;10(4):e0122805
Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells.
Sarveswaran S, Chakraborty D, Chitale D, Sears R, Ghosh J
The Journal of biological chemistry 2015 Feb 20;290(8):4994-5006
The Journal of biological chemistry 2015 Feb 20;290(8):4994-5006
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HL-60 cells were subjected to SDS PAGE followed by western blot with 10021-1-Ig( ALOX5 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using ALOX5 antibody 10021-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
