ABIN372586

antibody from antibodies-online

Targeting: ALOX5 5-LOX

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN372586

Provider

antibodies-online

Product name

anti-Arachidonate 5-Lipoxygenase (ALOX5) (pSer523) antibody

Antibody type

Polyclonal

Antigen

Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser523 of human 5-Lipoxygenase (5-LO).

Description

Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Reactivity

Human, Rat, Simian

Host

Rabbit

Epitope

pSer523

Isotype

IgG

Vial size

0.1 mL

Storage

Store the antibody undiluted (in aliquots) at-20°C.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523.

Luo M, Jones SM, Phare SM, Coffey MJ, Peters-Golden M, Brock TG
The Journal of biological chemistry 2004 Oct 1;279(40):41512-20

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Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.

Dwyer JH, Allayee H, Dwyer KM, Fan J, Wu H, Mar R, Lusis AJ, Mehrabian M
The New England journal of medicine 2004 Jan 1;350(1):29-37

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Prostaglandins and leukotrienes: advances in eicosanoid biology.

Funk CD
Science (New York, N.Y.) 2001 Nov 30;294(5548):1871-5

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Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis.

Wilborn J, Bailie M, Coffey M, Burdick M, Strieter R, Peters-Golden M
The Journal of clinical investigation 1996 Apr 15;97(8):1827-36

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Role of cysteinyl leukotrienes in spontaneous asthmatic responses.

Drazen JM, Lilly CM, Sperling R, Rubin P, Israel E
Advances in prostaglandin, thromboxane, and leukotriene research 1994;22:251-62