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- Antibody Data
- Antigen structure
- References [4]
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- Product number
- MAB366 - Provider product page
- Provider
- R&D Systems
- Product name
- Human CCL21/6Ckine Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human CCL21/6Ckine in direct ELISAs and Western blots. Does not cross-react with recombinant mouse (rm) CCL21, recombinant human (rh) MCP-1, rhMCP-2, rhMCP-3, rhMCP-4, rmMCP-5, rhMIP-1 alpha , rmMIP-1 alpha , rhMIP-1 beta , rmMIP-1 beta , rhMIP-1 delta , rmMIP-1 gamma , rmMIP-2, rhMIP-3 alpha , rmMIP-3 alpha , rrMIP-3 alpha , rhMIP-3 beta , rmMIP-3 beta , or rmCCL7.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
O00585- Isotype
- IgG
- Antibody clone number
- 54125
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin.
Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration.
Expression of podoplanin and other lymphatic markers in the human anterior eye segment.
Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.
Omland SH, Wettergren EE, Mollerup S, Asplund M, Mourier T, Hansen AJ, Gniadecki R
BMC cancer 2017 Oct 7;17(1):675
BMC cancer 2017 Oct 7;17(1):675
Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration.
Johnson LA, Jackson DG
International immunology 2010 Oct;22(10):839-49
International immunology 2010 Oct;22(10):839-49
Expression of podoplanin and other lymphatic markers in the human anterior eye segment.
Birke K, Lütjen-Drecoll E, Kerjaschki D, Birke MT
Investigative ophthalmology & visual science 2010 Jan;51(1):344-54
Investigative ophthalmology & visual science 2010 Jan;51(1):344-54
Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.
Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM
The American journal of pathology 2007 Apr;170(4):1152-64
The American journal of pathology 2007 Apr;170(4):1152-64
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