Antibody data
- Antibody Data
- Antigen structure
- References [26]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 17840-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17840-1-AP, RRID:AB_2226163
- Product name
- AHR antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated AHR antibody (Cat. #17840-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy.
Antitumor Effect of Fluoxetine on Chronic Stress-Promoted Lung Cancer Growth via Suppressing Kynurenine Pathway and Enhancing Cellular Immunity.
Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin.
High expression of aryl hydrocarbon receptor (AhR) plays an important role in the formation of fibrous epulis.
GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer.
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
The aryl hydrocarbon receptor ligand ITE inhibits cell proliferation and migration and enhances sensitivity to drug-resistance in hepatocellular carcinoma.
Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome.
Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice.
Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota via the Aryl Hydrocarbon Receptor.
Fine Particulate Matter (PM2.5) Promotes CD146 Expression in Alveolar Epithelial Cells and Cryptococcus neoformans Pulmonary Infection.
Tangshen formula modulates gut Microbiota and reduces gut-derived toxins in diabetic nephropathy rats.
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
Aryl hydrocarbon receptor mediates Jak2/STAT3 signaling for non-small cell lung cancer stem cell maintenance.
Oct4 plays a role in 2, 3, 7, 8 - tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation.
Aryl Hydrocarbon Receptor in Cutaneous Vascular Endothelial Cells Restricts Psoriasis Development by Negatively Regulating Neutrophil Recruitment.
Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway.
The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation.
A Network Pharmacology Approach for Uncovering the Osteogenic Mechanisms of Psoralea corylifolia Linn.
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis.
Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes.
Oral administration of oleanolic acid, isolated from Swertia mussotii Franch, attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats.
Swertianlarin, isolated from Swertia mussotii Franch, increases detoxification enzymes and efflux transporters expression in rats.
Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction.
Liang R, Tong X, Dong Z, Qin W, Fan L, Bai Z, Zhang Z, Xiang T, Wang Z, Tan N
Journal of ethnopharmacology 2022 Jan 30;283:114664
Journal of ethnopharmacology 2022 Jan 30;283:114664
Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy.
van de Veerdonk FL, Renga G, Pariano M, Bellet MM, Servillo G, Fallarino F, De Luca A, Iannitti RG, Piobbico D, Gargaro M, Manni G, D'Onofrio F, Stincardini C, Sforna L, Borghi M, Castelli M, Pieroni S, Oikonomou V, Villella VR, Puccetti M, Giovagnoli S, Galarini R, Barola C, Maiuri L, Della Fazia MA, Cellini B, Talesa VN, Dinarello CA, Costantini C, Romani L
The Journal of clinical investigation 2022 Jan 18;132(2)
The Journal of clinical investigation 2022 Jan 18;132(2)
Antitumor Effect of Fluoxetine on Chronic Stress-Promoted Lung Cancer Growth via Suppressing Kynurenine Pathway and Enhancing Cellular Immunity.
Yang Z, Li Z, Guo Z, Ren Y, Zhou T, Xiao Z, Duan J, Han C, Cheng Y, Xu F
Frontiers in pharmacology 2021;12:685898
Frontiers in pharmacology 2021;12:685898
Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin.
Qian C, Yang C, Lu M, Bao J, Shen H, Deng B, Li S, Li W, Zhang M, Cao C
Theranostics 2021;11(18):8797-8812
Theranostics 2021;11(18):8797-8812
High expression of aryl hydrocarbon receptor (AhR) plays an important role in the formation of fibrous epulis.
Zeng X, Xia S, Yan X, Hu C, An K, Luo L
Oral diseases 2021 Jun 17;
Oral diseases 2021 Jun 17;
GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer.
Wei JL, Wu SY, Yang YS, Xiao Y, Jin X, Xu XE, Hu X, Li DQ, Jiang YZ, Shao ZM
Journal for immunotherapy of cancer 2021 Jul;9(7)
Journal for immunotherapy of cancer 2021 Jul;9(7)
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
Li H, Wang YG, Ma ZC, Yun-Hang G, Ling S, Teng-Fei C, Guang-Ping Z, Gao Y
Xenobiotica; the fate of foreign compounds in biological systems 2021 Jul;51(7):752-763
Xenobiotica; the fate of foreign compounds in biological systems 2021 Jul;51(7):752-763
The aryl hydrocarbon receptor ligand ITE inhibits cell proliferation and migration and enhances sensitivity to drug-resistance in hepatocellular carcinoma.
Zhang X, He B, Chen E, Lu J, Wang J, Cao H, Li L
Journal of cellular physiology 2021 Jan;236(1):178-192
Journal of cellular physiology 2021 Jan;236(1):178-192
Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome.
Kunitomi C, Harada M, Kusamoto A, Azhary JM, Nose E, Koike H, Xu Z, Urata Y, Takahashi N, Wada-Hiraike O, Hirota Y, Koga K, Fujii T, Osuga Y
Molecular human reproduction 2021 Feb 27;27(3)
Molecular human reproduction 2021 Feb 27;27(3)
Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice.
Shi Z, Lei H, Chen G, Yuan P, Cao Z, Ser HL, Zhu X, Wu F, Liu C, Dong M, Song Y, Guo Y, Chen C, Hu K, Zhu Y, Zeng XA, Zhou J, Lu Y, Patterson AD, Zhang L
mSystems 2021 Feb 23;6(1)
mSystems 2021 Feb 23;6(1)
Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota via the Aryl Hydrocarbon Receptor.
Li X, Lu C, Fan D, Lu X, Xia Y, Zhao H, Xu H, Zhu Y, Li J, Liu H, Xiao C
Frontiers in cell and developmental biology 2020;8:131
Frontiers in cell and developmental biology 2020;8:131
Fine Particulate Matter (PM2.5) Promotes CD146 Expression in Alveolar Epithelial Cells and Cryptococcus neoformans Pulmonary Infection.
Sun Z, Ji N, Jiang J, Tao Y, Zhang E, Yang X, Wang Z, Chen Z, Huang M, Zhang M
Frontiers in microbiology 2020;11:525976
Frontiers in microbiology 2020;11:525976
Tangshen formula modulates gut Microbiota and reduces gut-derived toxins in diabetic nephropathy rats.
Zhao T, Zhang H, Yin X, Zhao H, Ma L, Yan M, Peng L, Wang Q, Dong X, Li P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110325
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110325
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
Xu Y, Fang H, Xu Q, Xu C, Yang L, Huang C
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
Cell cycle (Georgetown, Tex.) 2020 Nov;19(22):3054-3065
Aryl hydrocarbon receptor mediates Jak2/STAT3 signaling for non-small cell lung cancer stem cell maintenance.
Xiong J, Zhang X, Zhang Y, Wu B, Fang L, Wang N, Yi H, Chang N, Chen L, Zhang J
Experimental cell research 2020 Nov 1;396(1):112288
Experimental cell research 2020 Nov 1;396(1):112288
Oct4 plays a role in 2, 3, 7, 8 - tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation.
Tao Y, Liu X, Cui L, Liu X, Chen Y, He Z, Ji M, Gao Z, Li N, Wan Z, Yu Z
Toxicology 2020 May 30;438:152444
Toxicology 2020 May 30;438:152444
Aryl Hydrocarbon Receptor in Cutaneous Vascular Endothelial Cells Restricts Psoriasis Development by Negatively Regulating Neutrophil Recruitment.
Zhu Z, Chen J, Lin Y, Zhang C, Li W, Qiao H, Fu M, Dang E, Wang G
The Journal of investigative dermatology 2020 Jun;140(6):1233-1243.e9
The Journal of investigative dermatology 2020 Jun;140(6):1233-1243.e9
Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway.
Du L, Xing Z, Tao B, Li T, Yang D, Li W, Zheng Y, Kuang C, Yang Q
Signal transduction and targeted therapy 2020 Feb 21;5(1):10
Signal transduction and targeted therapy 2020 Feb 21;5(1):10
The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation.
Zhang M, Fan H, Tan S, Tang Q, Liu X, Zuo D, Liao Y, Nan Z, Tan C
Journal of ethnopharmacology 2020 Apr 6;251:112549
Journal of ethnopharmacology 2020 Apr 6;251:112549
A Network Pharmacology Approach for Uncovering the Osteogenic Mechanisms of Psoralea corylifolia Linn.
Ge L, Cheng K, Han J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2160175
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2160175
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Xia H, Zhu X, Zhang X, Jiang H, Li B, Wang Z, Li D, Jin Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109287
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109287
Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis.
Jia Y, Tao Y, Lv C, Xia Y, Wei Z, Dai Y
Cell death & disease 2019 Jan 15;10(2):38
Cell death & disease 2019 Jan 15;10(2):38
Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes.
Liu Q, Wu J, Song J, Liang P, Zheng K, Xiao G, Liu L, Zouboulis CC, Lei T
International journal of molecular medicine 2017 Oct;40(4):1029-1036
International journal of molecular medicine 2017 Oct;40(4):1029-1036
Oral administration of oleanolic acid, isolated from Swertia mussotii Franch, attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats.
Chai J, Du X, Chen S, Feng X, Cheng Y, Zhang L, Gao Y, Li S, He X, Wang R, Zhou X, Yang Y, Luo W, Chen W
International journal of clinical and experimental medicine 2015;8(2):1691-702
International journal of clinical and experimental medicine 2015;8(2):1691-702
Swertianlarin, isolated from Swertia mussotii Franch, increases detoxification enzymes and efflux transporters expression in rats.
Feng XC, Du X, Chen S, Yue D, Cheng Y, Zhang L, Gao Y, Li S, Chen L, Peng Z, Yang Y, Luo W, Wang R, Chen W, Chai J
International journal of clinical and experimental pathology 2015;8(1):184-95
International journal of clinical and experimental pathology 2015;8(1):184-95
Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstruction.
Chai J, Feng X, Zhang L, Chen S, Cheng Y, He X, Yang Y, He Y, Wang H, Wang R, Chen W
PloS one 2015;10(3):e0120055
PloS one 2015;10(3):e0120055
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 17840-1-AP(AHR antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AHR antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AHR. This antibody recognizes human, mouse antigen. The AHR antibody has been validated for the following applications: ELISA, WB, IHC analysis.