Antibody data
- Antibody Data
- Antigen structure
- References [95]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
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- Product number
- 23936-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#23936-1-AP, RRID:AB_2736836
- Product name
- CTGF antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CTGF antibody (Cat. #23936-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Activating autophagy promotes skin regeneration induced by mechanical stretch during tissue expansion.
YAP/TAZ activation mediates PQ-induced lung fibrosis by sustaining senescent pulmonary epithelial cells.
Natural intestinal metabolite xylitol reduces BRD4 levels to mitigate renal fibrosis.
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway.
Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.
YAP1 expression in colorectal cancer confers the aggressive phenotypes via its target genes.
Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis.
Ezrin promotes esophageal squamous cell carcinoma progression via the Hippo signaling pathway.
Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
A novel mechanism regulating pyroptosis-induced fibrosis in endometriosis via lnc-MALAT1/miR-141-3p/NLRP3 pathway†.
TEAD1 trapping by the Q353R-Lamin A/C causes dilated cardiomyopathy.
Activation of TRPV4 by lactate as a critical mediator of renal fibrosis in spontaneously hypertensive rats after moderate- and high-intensity exercise.
Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy.
Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals.
Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway.
MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes.
Inhibition of Ras protein activator like 2 produces antitumor effects in gastric cancer via the suppression of YAP1 activation.
Restraint of chaperonin containing T-complex protein-1 subunit 3 has antitumor roles in non-small cell lung cancer via affection of YAP1.
Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex.
OTUB2 Regulates YAP1/TAZ to Promotes the Progression of Esophageal Squamous Cell Carcinoma.
Serum and glucocorticoid-regulated kinase 1 regulates transforming growth factor β1-connective tissue growth factor pathway in chronic rhinosinusitis.
RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1.
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease.
MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13.
O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression.
JMJD1A/NR4A1 Signaling Regulates the Procession of Renal Tubular Epithelial Interstitial Fibrosis Induced by AGEs in HK-2.
RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells.
Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway.
Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.
Low-intensity pulsed ultrasound inhibits fibroblast-like synoviocyte proliferation and reduces synovial fibrosis by regulating Wnt/β-catenin signaling.
MicroRNA-550a-3-5p controls the brain metastasis of lung cancer by directly targeting YAP1.
Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1.
Mesenchymal Stem Cell-Derived Exosomes Ameliorate Dermal Fibrosis in a Murine Model of Bleomycin-Induced Scleroderma.
The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis.
AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
Long non-coding RNA CCAT2 drives the growth of laryngeal squamous cell carcinoma via regulating YAP activity.
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.
Citrus Alkaline Extracts Inhibit Senescence of A549 Cells to Alleviate Pulmonary Fibrosis via the β-Catenin/P53 Pathway.
Icaritin Inhibits Skin Fibrosis through Regulating AMPK and Wnt/β-catenin Signaling.
Selective exosome exclusion of miR-375 by glioma cells promotes glioma progression by activating the CTGF-EGFR pathway.
Prenatal caffeine exposure caused H-type blood vessel-related long bone dysplasia via miR375/CTGF signaling.
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling.
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.
PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells.
Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model.
The association between RGS4 and choline in cardiac fibrosis.
Cyclic Stretch Induces Vascular Smooth Muscle Cells to Secrete Connective Tissue Growth Factor and Promote Endothelial Progenitor Cell Differentiation and Angiogenesis.
Histone Deacetylase 11 Contributes to Renal Fibrosis by Repressing KLF15 Transcription.
Biological and Proteomic Characteristics of an Immortalized Human Pancreatic Stellate Cell Line.
Integrated Analysis of Key Genes and Pathways Involved in Fetal Growth Restriction and Their Associations With the Dysregulation of the Maternal Immune System.
FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis.
MKL1 mediates TGF-β-induced CTGF transcription to promote renal fibrosis.
Lactoferrin Contributes a Renoprotective Effect in Acute Kidney Injury and Early Renal Fibrosis.
Epigenetic activation of CTGF transcription by high glucose in renal tubular epithelial cells is mediated by myocardin-related transcription factor A.
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
RETRACTED: The protective role of microRNA-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing CTGF.
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.
Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.
LncRNA MIAT/miR-133a-3p axis regulates atrial fibrillation and atrial fibrillation-induced myocardial fibrosis.
The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10.
Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway.
CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging.
A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway.
miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.
Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis.
Hyperoside protects against heart failure-induced liver fibrosis in rats.
CTGF regulates cyclic stretch-induced vascular smooth muscle cell proliferation via microRNA-19b-3p.
Induction of Fibrosis and Autophagy in Kidney Cells by Vinyl Chloride.
Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.
SRT1720 retards renal fibrosis via inhibition of HIF1α /GLUT1 in diabetic nephropathy.
Upregulation of microRNA-133a and downregulation of connective tissue growth factor suppress cell proliferation, migration, and invasion in human glioma through the JAK/STAT signaling pathway.
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.
Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.
Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.
Decreased expression of LATS1 correlates with astrogliosis after spinal cord injury.
Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis.
A key role of microRNA-26a in the scar formation after glaucoma filtration surgery.
Hyperglycemia activates the renin-angiotensin system and induces epithelial-mesenchymal transition in streptozotocin-induced diabetic kidneys.
Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling.
Exogenous CGRP upregulates profibrogenic growth factors through PKC/JNK signaling pathway in kidney proximal tubular cells.
Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior.
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.
Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition.
Expression of fibrosis-related molecules in the oral mucosa of six animal species: A reference for selecting animal models.
Genome-wide expression differences in anti-Vegf and dexamethasone treatment of inflammatory angiogenesis in the rat cornea.
LATS1 suppresses proliferation and invasion of cervical cancer.
Crucial Role of miR-433 in Regulating Cardiac Fibrosis.
Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.
Up-regulation of the Hippo pathway effector TAZ renders lung adenocarcinoma cells harboring EGFR-T790M mutation resistant to gefitinib.
A hairpin within YAP mRNA 3'UTR functions in regulation at post-transcription level.
MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR.
Du J, Liu W, Song Y, Zhang Y, Dong C, Xiong S, Huang Z, Wang T, Ding J, He Q, Yu Z, Ma X
Burns & trauma 2024;12:tkad057
Burns & trauma 2024;12:tkad057
YAP/TAZ activation mediates PQ-induced lung fibrosis by sustaining senescent pulmonary epithelial cells.
Yu Y, Chu C, Wang K, Li Y, Mao Z, Hu L, Wang J, Yu Y, Sun H, Chen F
Respiratory research 2024 May 18;25(1):212
Respiratory research 2024 May 18;25(1):212
Natural intestinal metabolite xylitol reduces BRD4 levels to mitigate renal fibrosis.
Tan Z, Wang Z, Zeng Q, Liu X, Zhang Y, Li S, Huang J, Zeng Y, Huang Z, Jin C, Fu N, Zhao Q, Mu Y, Wang Z, Xiao J, Yang H, Ke G
Clinical and translational science 2024 Mar;17(3):e13770
Clinical and translational science 2024 Mar;17(3):e13770
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway.
Li Y, Zhu T, Yang J, Zhang Q, Xu S, Ge S, Jia R, Zhang J, Fan X
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1187-1203
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1187-1203
Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.
Li H, Qin S, Tang J, Wang T, Ren W, Di L, Bo W, Ma Y, Wu F, Xu Z, Song W, Cai M, Xi Y, Tian Z
Acta physiologica (Oxford, England) 2024 Jul;240(7):e14163
Acta physiologica (Oxford, England) 2024 Jul;240(7):e14163
YAP1 expression in colorectal cancer confers the aggressive phenotypes via its target genes.
Chen H, Shang Y, Li X, Wang R
Cell cycle (Georgetown, Tex.) 2024 Jan;23(1):83-91
Cell cycle (Georgetown, Tex.) 2024 Jan;23(1):83-91
Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis.
Chen X, Wang H, Wu C, Li X, Huang X, Ren Y, Pu Q, Cao Z, Tang X, Ding BS
Redox biology 2024 Apr;70:103038
Redox biology 2024 Apr;70:103038
Ezrin promotes esophageal squamous cell carcinoma progression via the Hippo signaling pathway.
Ma L, Liu L, Ji M, Su L, Guan Y, Xiao J, Pu H
Open life sciences 2023;18(1):20220743
Open life sciences 2023;18(1):20220743
Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.
Pusec CM, Ilievski V, De Jesus A, Farooq Z, Zapater JL, Sweis N, Ismail H, Khan MW, Ardehali H, Cordoba-Chacon J, Layden BT
Scientific reports 2023 May 17;13(1):8034
Scientific reports 2023 May 17;13(1):8034
A novel mechanism regulating pyroptosis-induced fibrosis in endometriosis via lnc-MALAT1/miR-141-3p/NLRP3 pathway†.
Xu Y, Liu H, Xiong W, Peng Y, Li X, Long X, Jin J, Liang J, Weng R, Liu J, Zhang L, Liu Y
Biology of reproduction 2023 Aug 10;109(2):156-171
Biology of reproduction 2023 Aug 10;109(2):156-171
TEAD1 trapping by the Q353R-Lamin A/C causes dilated cardiomyopathy.
Yamada S, Ko T, Ito M, Sassa T, Nomura S, Okuma H, Sato M, Imasaki T, Kikkawa S, Zhang B, Yamada T, Seki Y, Fujita K, Katoh M, Kubota M, Hatsuse S, Katagiri M, Hayashi H, Hamano M, Takeda N, Morita H, Takada S, Toyoda M, Uchiyama M, Ikeuchi M, Toyooka K, Umezawa A, Yamanishi Y, Nitta R, Aburatani H, Komuro I
Science advances 2023 Apr 14;9(15):eade7047
Science advances 2023 Apr 14;9(15):eade7047
Activation of TRPV4 by lactate as a critical mediator of renal fibrosis in spontaneously hypertensive rats after moderate- and high-intensity exercise.
Zhao B, Xu Y, Chen Y, Cai Y, Gong Z, Li D, Kuang H, Liu X, Zhou H, Liu G, Yin Y
Frontiers in physiology 2022;13:927078
Frontiers in physiology 2022;13:927078
Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy.
Zheng CM, Lu KC, Chen YJ, Li CY, Lee YH, Chiu HW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113565
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113565
Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals.
Cai ZH, Tian YG, Li JZ, Zhao P, Li JS, Mei X, Bai YP
Bioscience reports 2022 Oct 28;42(10)
Bioscience reports 2022 Oct 28;42(10)
Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway.
Yan J, Honglei Y, Yun W, Sheng D, Yun H, Anhua Z, Na F, Min L, Dandan S, Jing W, Junming T, Wenjun Z, Xiju H
European journal of pharmacology 2022 Oct 15;933:175254
European journal of pharmacology 2022 Oct 15;933:175254
MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes.
Zhang Y, Hui J, Xu Y, Ma Y, Sun Z, Zhang M, Nie L, Ye L
Chemosphere 2022 May;295:133925
Chemosphere 2022 May;295:133925
Inhibition of Ras protein activator like 2 produces antitumor effects in gastric cancer via the suppression of YAP1 activation.
Hu Y, Zhang P, Shi Y, Dong X, Wu Y, Dong D, Li E, Fan Y
Environmental toxicology 2022 Mar;37(3):527-538
Environmental toxicology 2022 Mar;37(3):527-538
Restraint of chaperonin containing T-complex protein-1 subunit 3 has antitumor roles in non-small cell lung cancer via affection of YAP1.
Shi H, Zhang Y, Wang Y, Fang P, Liu Y, Li W
Toxicology and applied pharmacology 2022 Mar 15;439:115926
Toxicology and applied pharmacology 2022 Mar 15;439:115926
Abnormal activation of Yap/Taz contributes to the pathogenesis of tuberous sclerosis complex.
Terry BK, Park R, Cho SH, Crino PB, Kim S
Human molecular genetics 2022 Jun 22;31(12):1979-1996
Human molecular genetics 2022 Jun 22;31(12):1979-1996
OTUB2 Regulates YAP1/TAZ to Promotes the Progression of Esophageal Squamous Cell Carcinoma.
Liu L, Cheng H, Ji M, Su L, Lu Z, Hu X, Guan Y, Xiao J, Ma L, Zhang W, Pu H
Biological procedures online 2022 Jul 18;24(1):10
Biological procedures online 2022 Jul 18;24(1):10
Serum and glucocorticoid-regulated kinase 1 regulates transforming growth factor β1-connective tissue growth factor pathway in chronic rhinosinusitis.
Lai Y, Zhang P, Wang H, Hu L, Song X, Zhang J, Jiang W, Han M, Liu Q, Hu G, Sun X, Li H, Wang D
Clinical immunology (Orlando, Fla.) 2022 Jan;234:108895
Clinical immunology (Orlando, Fla.) 2022 Jan;234:108895
RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1.
Huang Y, Zou Y, Jie Z
Experimental and therapeutic medicine 2022 Feb;23(2):118
Experimental and therapeutic medicine 2022 Feb;23(2):118
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease.
Zheng Z, Zhang S, Chen J, Zou M, Yang Y, Lu W, Ren S, Wang X, Dong W, Zhang Z, Wang L, Guan M, Cheing GLY, Xue Y, Jia Y
Clinical science (London, England : 1979) 2022 Feb 11;136(3):223-238
Clinical science (London, England : 1979) 2022 Feb 11;136(3):223-238
MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13.
Jin X, Yu W, Ye P
Environmental toxicology 2022 Apr;37(4):730-740
Environmental toxicology 2022 Apr;37(4):730-740
O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression.
Liu YY, Liu HY, Yu TJ, Lu Q, Zhang FL, Liu GY, Shao ZM, Li DQ
Cell death and differentiation 2022 Apr;29(4):861-873
Cell death and differentiation 2022 Apr;29(4):861-873
JMJD1A/NR4A1 Signaling Regulates the Procession of Renal Tubular Epithelial Interstitial Fibrosis Induced by AGEs in HK-2.
Wang S, Zuo A, Jiang W, Xie J, Lin H, Sun W, Zhao M, Xia J, Shao J, Zhao X, Liang D, Yang A, Sun J, Wang M
Frontiers in medicine 2021;8:807694
Frontiers in medicine 2021;8:807694
RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells.
Liu Z, Li S, Qian X, Li L, Zhang H, Liu Z
Frontiers in molecular biosciences 2021;8:728932
Frontiers in molecular biosciences 2021;8:728932
Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway.
Liao X, Zhang Y, Xu B, Ali A, Liu X, Jia Q
Journal of Cancer 2021;12(20):6071-6080
Journal of Cancer 2021;12(20):6071-6080
Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.
Zhao W, Zhang X, Hou M, Zhang Y, Tang Y, Li L, Dong S, Liu L, Zhao D, Li W, Nan Y
Histology and histopathology 2021 Sep;36(9):967-979
Histology and histopathology 2021 Sep;36(9):967-979
Low-intensity pulsed ultrasound inhibits fibroblast-like synoviocyte proliferation and reduces synovial fibrosis by regulating Wnt/β-catenin signaling.
Liao B, Guan M, Tan Q, Wang G, Zhang R, Huang J, Liu M, Chen H, Li K, Bai D, Zhu Y
Journal of orthopaedic translation 2021 Sep;30:41-50
Journal of orthopaedic translation 2021 Sep;30:41-50
MicroRNA-550a-3-5p controls the brain metastasis of lung cancer by directly targeting YAP1.
Wei L, Wang G, Yang C, Zhang Y, Chen Y, Zhong C, Li Q
Cancer cell international 2021 Sep 16;21(1):491
Cancer cell international 2021 Sep 16;21(1):491
Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1.
Qi M, Liu X, Zhou Y, Wang H, Zhao Y, Ren J, Xiang J
International journal of molecular sciences 2021 Oct 24;22(21)
International journal of molecular sciences 2021 Oct 24;22(21)
Mesenchymal Stem Cell-Derived Exosomes Ameliorate Dermal Fibrosis in a Murine Model of Bleomycin-Induced Scleroderma.
Li M, Zhang HP, Wang XY, Chen ZG, Lin XF, Zhu W
Stem cells and development 2021 Oct 1;30(19):981-990
Stem cells and development 2021 Oct 1;30(19):981-990
The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis.
Yang M, Li S, Liu W, Li X, He Y, Yang Y, Sun K, Zhang L, Tian W, Duan L, Chen H, Yao D, Yang Z, Zhu X
Science China. Life sciences 2021 Nov;64(11):1868-1883
Science China. Life sciences 2021 Nov;64(11):1868-1883
AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
Fang P, Deng WJ, Fan N, Shi J, Shi HY, Ou L, Pan JL, Yang SY
Environmental toxicology 2021 Nov;36(11):2225-2235
Environmental toxicology 2021 Nov;36(11):2225-2235
Long non-coding RNA CCAT2 drives the growth of laryngeal squamous cell carcinoma via regulating YAP activity.
Zang Y, Li J, Wan B, Tai Y, Liu H, Li Q, Ji Y
Human cell 2021 Nov;34(6):1878-1887
Human cell 2021 Nov;34(6):1878-1887
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.
Xu D, Chen PP, Zheng PQ, Yin F, Cheng Q, Zhou ZL, Xie HY, Li JY, Ni JY, Wang YZ, Chen SJ, Zhou L, Wang XX, Liu J, Zhang W, Lu LM
Acta pharmacologica Sinica 2021 Mar;42(3):436-450
Acta pharmacologica Sinica 2021 Mar;42(3):436-450
Citrus Alkaline Extracts Inhibit Senescence of A549 Cells to Alleviate Pulmonary Fibrosis via the β-Catenin/P53 Pathway.
Han D, Xu Y, Peng WP, Feng F, Wang Z, Gu C, Zhou X
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 12;27:e928547
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 12;27:e928547
Icaritin Inhibits Skin Fibrosis through Regulating AMPK and Wnt/β-catenin Signaling.
Li M, Liu Q, He S, Kong X, Lin J, Huang Y, Wu W, Wu J
Cell biochemistry and biophysics 2021 Jun;79(2):231-238
Cell biochemistry and biophysics 2021 Jun;79(2):231-238
Selective exosome exclusion of miR-375 by glioma cells promotes glioma progression by activating the CTGF-EGFR pathway.
Xu X, Liu Y, Li Y, Chen H, Zhang Y, Liu J, Deng S, Zheng Y, Sun X, Wang J, Chen T, Huang M, Ke Y
Journal of experimental & clinical cancer research : CR 2021 Jan 6;40(1):16
Journal of experimental & clinical cancer research : CR 2021 Jan 6;40(1):16
Prenatal caffeine exposure caused H-type blood vessel-related long bone dysplasia via miR375/CTGF signaling.
He H, Luo H, Liu L, Shangguan Y, Xie X, Wen Y, Wang H, Chen L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21370
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21370
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Cui Y, Wang Y, Liu G
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling.
Xu G, Seng Z, Zhang M, Qu J
Environmental toxicology 2021 Dec;36(12):2500-2511
Environmental toxicology 2021 Dec;36(12):2500-2511
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
Zhao P, Cai Z, Tian Y, Li J, Li K, Li M, Bai Y, Li J
International immunopharmacology 2021 Dec;101(Pt B):108360
International immunopharmacology 2021 Dec;101(Pt B):108360
The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.
Liu T, Yang Y, Xie Z, Luo Q, Yang D, Liu X, Zhao H, Wei Q, Liu Y, Li L, Wang Y, Wang F, Yu J, Xu J, Yu J, Yi P
Molecular therapy. Nucleic acids 2021 Dec 3;26:388-400
Molecular therapy. Nucleic acids 2021 Dec 3;26:388-400
PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells.
Kusama K, Fukushima Y, Yoshida K, Azumi M, Yoshie M, Mizuno Y, Kajihara T, Tamura K
Endocrinology 2021 Dec 1;162(12)
Endocrinology 2021 Dec 1;162(12)
Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model.
Ji W, Zhu P, Liang R, Zhang L, Zhang Y, Wang Y, Zhang W, Tao L, Chen S, Yang H, Jin Y, Duan G
Viruses 2021 Aug 11;13(8)
Viruses 2021 Aug 11;13(8)
The association between RGS4 and choline in cardiac fibrosis.
Guo J, Hang P, Yu J, Li W, Zhao X, Sun Y, Fan Z, Du Z
Cell communication and signaling : CCS 2021 Apr 23;19(1):46
Cell communication and signaling : CCS 2021 Apr 23;19(1):46
Cyclic Stretch Induces Vascular Smooth Muscle Cells to Secrete Connective Tissue Growth Factor and Promote Endothelial Progenitor Cell Differentiation and Angiogenesis.
Yan J, Wang WB, Fan YJ, Bao H, Li N, Yao QP, Huo YL, Jiang ZL, Qi YX, Han Y
Frontiers in cell and developmental biology 2020;8:606989
Frontiers in cell and developmental biology 2020;8:606989
Histone Deacetylase 11 Contributes to Renal Fibrosis by Repressing KLF15 Transcription.
Mao L, Liu L, Zhang T, Qin H, Wu X, Xu Y
Frontiers in cell and developmental biology 2020;8:235
Frontiers in cell and developmental biology 2020;8:235
Biological and Proteomic Characteristics of an Immortalized Human Pancreatic Stellate Cell Line.
Sun L, Qu L, Brigstock DR, Li H, Li Y, Gao R
International journal of medical sciences 2020;17(1):137-144
International journal of medical sciences 2020;17(1):137-144
Integrated Analysis of Key Genes and Pathways Involved in Fetal Growth Restriction and Their Associations With the Dysregulation of the Maternal Immune System.
Wang X, Zhu H, Lei L, Zhang Y, Tang C, Wu JX, Zhou JR, Xiao XR
Frontiers in genetics 2020;11:581789
Frontiers in genetics 2020;11:581789
FAM83A Promotes Lung Cancer Progression by Regulating the Wnt and Hippo Signaling Pathways and Indicates Poor Prognosis.
Zheng YW, Li ZH, Lei L, Liu CC, Wang Z, Fei LR, Yang MQ, Huang WJ, Xu HT
Frontiers in oncology 2020;10:180
Frontiers in oncology 2020;10:180
MKL1 mediates TGF-β-induced CTGF transcription to promote renal fibrosis.
Mao L, Liu L, Zhang T, Wu X, Zhang T, Xu Y
Journal of cellular physiology 2020 May;235(5):4790-4803
Journal of cellular physiology 2020 May;235(5):4790-4803
Lactoferrin Contributes a Renoprotective Effect in Acute Kidney Injury and Early Renal Fibrosis.
Hsu YH, Chiu IJ, Lin YF, Chen YJ, Lee YH, Chiu HW
Pharmaceutics 2020 May 8;12(5)
Pharmaceutics 2020 May 8;12(5)
Epigenetic activation of CTGF transcription by high glucose in renal tubular epithelial cells is mediated by myocardin-related transcription factor A.
Shao J, Xu H, Wu X, Xu Y
Cell and tissue research 2020 Mar;379(3):549-559
Cell and tissue research 2020 Mar;379(3):549-559
Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-β1 pathway and interfering with MMP-TIMPs expression.
Su C, Wang Q, Luo H, Jiao W, Tang J, Li L, Tian L, Chen X, Liu B, Yu X, Li S, Guo S, Wang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110132
RETRACTED: The protective role of microRNA-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing CTGF.
Pei G, Xu L, Huang W, Yin J
International immunopharmacology 2020 Jan;78:106076
International immunopharmacology 2020 Jan;78:106076
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
Jin W, Zhang Y, Xue Y, Han X, Zhang X, Ma Z, Sun S, Chu X, Cheng J, Guan S, Li Z, Chu L
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):13-23
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):13-23
Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.
Wei L, Cao P, Xu C, Zhong H, Wang X, Bai M, Hu B, Wang R, Liu N, Tian Y, Chen H, Li J, Yuan W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):16581-16600
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):16581-16600
Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.
Miao X, Zhang N
Experimental and molecular pathology 2020 Dec;117:104546
Experimental and molecular pathology 2020 Dec;117:104546
LncRNA MIAT/miR-133a-3p axis regulates atrial fibrillation and atrial fibrillation-induced myocardial fibrosis.
Yao L, Zhou B, You L, Hu H, Xie R
Molecular biology reports 2020 Apr;47(4):2605-2617
Molecular biology reports 2020 Apr;47(4):2605-2617
The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10.
Yang X, Li S, Wu Y, Ge F, Chen Y, Xiong Q
BMC cancer 2020 Apr 15;20(1):312
BMC cancer 2020 Apr 15;20(1):312
Inhibitory Effect of Corilagin on miR-21-Regulated Hepatic Fibrosis Signaling Pathway.
Zhou X, Xiong J, Lu S, Luo L, Chen ZL, Yang F, Jin F, Wang Y, Ma Q, Luo YY, Wang YJ, Zhou JB, Liu P, Zhao L
The American journal of Chinese medicine 2019;47(7):1541-1569
The American journal of Chinese medicine 2019;47(7):1541-1569
CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging.
Rui YF, Chen MH, Li YJ, Xiao LF, Geng P, Wang P, Xu ZY, Zhang XP, Dai GC
Stem cells international 2019;2019:6257537
Stem cells international 2019;2019:6257537
A Novel Liposomal S-Propargyl-Cysteine: A Sustained Release of Hydrogen Sulfide Reducing Myocardial Fibrosis via TGF-β1/Smad Pathway.
Tran BH, Yu Y, Chang L, Tan B, Jia W, Xiong Y, Dai T, Zhong R, Zhang W, Le VM, Rose P, Wang Z, Mao Y, Zhu YZ
International journal of nanomedicine 2019;14:10061-10077
International journal of nanomedicine 2019;14:10061-10077
miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.
Xu X, Chen X, Xu M, Liu X, Pan B, Qin J, Xu T, Zeng K, Pan Y, He B, Sun H, Sun L, Wang S
Aging 2019 Sep 22;11(18):7357-7385
Aging 2019 Sep 22;11(18):7357-7385
Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis.
Wei P, Xie Y, Abel PW, Huang Y, Ma Q, Li L, Hao J, Wolff DW, Wei T, Tu Y
Cell death & disease 2019 Sep 11;10(9):670
Cell death & disease 2019 Sep 11;10(9):670
Hyperoside protects against heart failure-induced liver fibrosis in rats.
Guo X, Zhu C, Liu X, Ge Y, Jiang X, Zhao W
Acta histochemica 2019 Oct;121(7):804-811
Acta histochemica 2019 Oct;121(7):804-811
CTGF regulates cyclic stretch-induced vascular smooth muscle cell proliferation via microRNA-19b-3p.
Wang WB, Li HP, Yan J, Zhuang F, Bao M, Liu JT, Qi YX, Han Y
Experimental cell research 2019 Mar 1;376(1):77-85
Experimental cell research 2019 Mar 1;376(1):77-85
Induction of Fibrosis and Autophagy in Kidney Cells by Vinyl Chloride.
Hsu YH, Chuang HC, Lee YH, Lin YF, Chiu YJ, Wang YL, Wu MS, Chiu HW
Cells 2019 Jun 17;8(6)
Cells 2019 Jun 17;8(6)
Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.
Wang T, Fu X, Jin T, Zhang L, Liu B, Wu Y, Xu F, Wang X, Ye K, Zhang W, Ye L
EBioMedicine 2019 Jul;45:168-180
EBioMedicine 2019 Jul;45:168-180
SRT1720 retards renal fibrosis via inhibition of HIF1α /GLUT1 in diabetic nephropathy.
Han W, Wang C, Yang Z, Mu L, Wu M, Chen N, Du C, Duan H, Shi Y
The Journal of endocrinology 2019 Feb 1;
The Journal of endocrinology 2019 Feb 1;
Upregulation of microRNA-133a and downregulation of connective tissue growth factor suppress cell proliferation, migration, and invasion in human glioma through the JAK/STAT signaling pathway.
Zhang P, Chen FZ, Jia QB, Hu DF
IUBMB life 2019 Dec;71(12):1857-1875
IUBMB life 2019 Dec;71(12):1857-1875
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
Feng F, Wang Z, Li R, Wu Q, Gu C, Xu Y, Peng W, Han D, Zhou X, Wu J, He H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.
Li M, Chen J, Yu X, Xu S, Li D, Zheng Q, Yin Y
Cells 2019 Apr 17;8(4)
Cells 2019 Apr 17;8(4)
Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.
Gao M, Chen M, Li C, Xu M, Liu Y, Cong M, Sang N, Liu S
Cell discovery 2018;4:5
Cell discovery 2018;4:5
Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.
Wang Q, Zang W, Han L, Yang L, Ye S, Ouyang J, Zhang C, Bi Y, Zhang C, Bian H
Chinese medicine 2018;13:17
Chinese medicine 2018;13:17
Decreased expression of LATS1 correlates with astrogliosis after spinal cord injury.
Wang Y, Chen M
Biochemical and biophysical research communications 2018 Oct 20;505(1):151-156
Biochemical and biophysical research communications 2018 Oct 20;505(1):151-156
Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis.
Cui K, Tang Z, Li CC, Wang T, Rao K, Wang SG, Liu JH, Chen Z
Asian journal of andrology 2018 Mar-Apr;20(2):166-172
Asian journal of andrology 2018 Mar-Apr;20(2):166-172
A key role of microRNA-26a in the scar formation after glaucoma filtration surgery.
Wang WH, Deng AJ, He SG
Artificial cells, nanomedicine, and biotechnology 2018 Jun;46(4):831-837
Artificial cells, nanomedicine, and biotechnology 2018 Jun;46(4):831-837
Hyperglycemia activates the renin-angiotensin system and induces epithelial-mesenchymal transition in streptozotocin-induced diabetic kidneys.
Chen CM, Juan SH, Chou HC
Journal of the renin-angiotensin-aldosterone system : JRAAS 2018 Jul-Sep;19(3):1470320318803009
Journal of the renin-angiotensin-aldosterone system : JRAAS 2018 Jul-Sep;19(3):1470320318803009
Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling.
Zhang X, Ma ZG, Yuan YP, Xu SC, Wei WY, Song P, Kong CY, Deng W, Tang QZ
Cell death & disease 2018 Jan 24;9(2):102
Cell death & disease 2018 Jan 24;9(2):102
Exogenous CGRP upregulates profibrogenic growth factors through PKC/JNK signaling pathway in kidney proximal tubular cells.
Yoon SP, Kim J
Cell biology and toxicology 2018 Aug;34(4):251-262
Cell biology and toxicology 2018 Aug;34(4):251-262
Expression of YAP/TAZ in Keratocystic Odontogenic Tumors and Its Possible Association with Proliferative Behavior.
Man QW, Ma YQ, Liu JY, Zhao Y, Liu B, Zhao YF
BioMed research international 2017;2017:4624890
BioMed research international 2017;2017:4624890
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.
Cui K, Ruan Y, Wang T, Rao K, Chen Z, Wang S, Liu J
The journal of sexual medicine 2017 Mar;14(3):323-335
The journal of sexual medicine 2017 Mar;14(3):323-335
Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition.
Wu QQ, Xiao Y, Jiang XH, Yuan Y, Yang Z, Chang W, Bian ZY, Tang QZ
Molecular and cellular biochemistry 2017 Jun;430(1-2):81-90
Molecular and cellular biochemistry 2017 Jun;430(1-2):81-90
Expression of fibrosis-related molecules in the oral mucosa of six animal species: A reference for selecting animal models.
Sa G, Xiong X, Ren J, Zhao Y, He S
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Jan 1;96:472-478
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Jan 1;96:472-478
Genome-wide expression differences in anti-Vegf and dexamethasone treatment of inflammatory angiogenesis in the rat cornea.
Mirabelli P, Mukwaya A, Lennikov A, Xeroudaki M, Peebo B, Schaupper M, Lagali N
Scientific reports 2017 Aug 15;7(1):7616
Scientific reports 2017 Aug 15;7(1):7616
LATS1 suppresses proliferation and invasion of cervical cancer.
Deng J, Zhang W, Liu S, An H, Tan L, Ma L
Molecular medicine reports 2017 Apr;15(4):1654-1660
Molecular medicine reports 2017 Apr;15(4):1654-1660
Crucial Role of miR-433 in Regulating Cardiac Fibrosis.
Tao L, Bei Y, Chen P, Lei Z, Fu S, Zhang H, Xu J, Che L, Chen X, Sluijter JP, Das S, Cretoiu D, Xu B, Zhong J, Xiao J, Li X
Theranostics 2016;6(12):2068-2083
Theranostics 2016;6(12):2068-2083
Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.
Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, Zhang X, Ye L
Oncogene 2016 Aug 4;35(31):4048-57
Oncogene 2016 Aug 4;35(31):4048-57
Up-regulation of the Hippo pathway effector TAZ renders lung adenocarcinoma cells harboring EGFR-T790M mutation resistant to gefitinib.
Xu W, Wei Y, Wu S, Wang Y, Wang Z, Sun Y, Cheng SY, Wu J
Cell & bioscience 2015;5:7
Cell & bioscience 2015;5:7
A hairpin within YAP mRNA 3'UTR functions in regulation at post-transcription level.
Gao Y, Wang Y, Feng J, Feng G, Zheng M, Yang Z, Xiao Z, Lu Z, Ye L, Zhang X
Biochemical and biophysical research communications 2015 Apr 3;459(2):306-312
Biochemical and biophysical research communications 2015 Apr 3;459(2):306-312
MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR.
Wang Y, Cui M, Sun BD, Liu FB, Zhang XD, Ye LH
Acta pharmacologica Sinica 2014 Sep;35(9):1207-14
Acta pharmacologica Sinica 2014 Sep;35(9):1207-14
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 23936-1-AP( CTGF Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CTGF antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CTGF. This antibody recognizes human, mouse, rat antigen. The CTGF antibody has been validated for the following applications: ELISA, IHC, WB analysis.