Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- MAB660-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human CTGF/CCN2 C-Terminus Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human CTGF C-teriminal peptide in direct ELISAs. Does not cross-react with recombinant human (rh) LDGF, rhNOV, rhPDGF, rhPlGF, rhVEGF206, rhVEGF-B186, rhVEGF-C, rhVEGF-D, or rhWISP-1.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
NP_001892.1
- Isotype
- IgG
- Antibody clone number
- 88430
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Curcumin inhibits TGF-β1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts.
Human gingiva transcriptome during wound healing.
Anti-CTGF single-chain variable fragment dimers inhibit human airway smooth muscle (ASM) cell proliferation by down-regulating p-Akt and p-mTOR levels.
A physiological role for connective tissue growth factor in early wound healing.
CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway.
Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.
Chen JT, Wang CY, Chen MH
Journal of the Formosan Medical Association = Taiwan yi zhi 2018 Dec;117(12):1115-1123
Journal of the Formosan Medical Association = Taiwan yi zhi 2018 Dec;117(12):1115-1123
Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology 2017 Apr;44(4):394-402
Journal of clinical periodontology 2017 Apr;44(4):394-402
Anti-CTGF single-chain variable fragment dimers inhibit human airway smooth muscle (ASM) cell proliferation by down-regulating p-Akt and p-mTOR levels.
Gao W, Cai L, Xu X, Fan J, Xue X, Yan X, Qu Q, Wang X, Zhang C, Wu G
PloS one 2014;9(12):e113980
PloS one 2014;9(12):e113980
A physiological role for connective tissue growth factor in early wound healing.
Alfaro MP, Deskins DL, Wallus M, DasGupta J, Davidson JM, Nanney LB, A Guney M, Gannon M, Young PP
Laboratory investigation; a journal of technical methods and pathology 2013 Jan;93(1):81-95
Laboratory investigation; a journal of technical methods and pathology 2013 Jan;93(1):81-95
CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway.
Chen PS, Wang MY, Wu SN, Su JL, Hong CC, Chuang SE, Chen MW, Hua KT, Wu YL, Cha ST, Babu MS, Chen CN, Lee PH, Chang KJ, Kuo ML
Journal of cell science 2007 Jun 15;120(Pt 12):2053-65
Journal of cell science 2007 Jun 15;120(Pt 12):2053-65
Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.
Grønborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A
Molecular & cellular proteomics : MCP 2006 Jan;5(1):157-71
Molecular & cellular proteomics : MCP 2006 Jan;5(1):157-71
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- CTGF/CCN2 in Human Breast Cancer Tissue. CTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 25 µg/mL Human CTGF/CCN2 C-Terminus Monoclonal Antibody (Catalog # MAB660) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.