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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [165]
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- Product number
- 66264-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#66264-1-Ig, RRID:AB_2716798
- Product name
- Cytochrome c antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Cytochrome c antibody (Cat. #66264-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2D8D11
- Vial size
- 20ul, 150ul
Submitted references Monitoring early micro-oxidation under refrigeration: iron and oxidative markers predict quality loss in grass carp.
Ageing-Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1-Meditated Ca(2+) Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice.
Mitochondrial-Disrupting Antimicrobial Peptide Nanoparticles as Precise Pyroptosis Inducers for Breast Cancer Immunotherapy.
Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton.
SHMT2 inhibition triggers mitochondrial apoptosis to suppress lung adenocarcinoma progression.
Characterization of cyclotide Vdif A from Viola diffusa inhibits non-small cell lung cancer cells via regulation of CKS2.
Single-cell transcriptomic atlas of shrimp hepatopancreas reveals an endoplasmic reticulum stress-dependent immune response to Vibrio parahaemolyticus infection.
γ-Glutamylcysteine Alleviates t-BHP-Induced Oxidative Damage in NIH/3T3 Fibroblasts by Promoting Nuclear Translocation of Nrf2.
Antitumor Cytisine-Platinum(IV) Prodrugs Potentiate Crosstalk between Endoplasmic Reticulum and Mitochondria through Calcium Overload Accompanied by Immunogenic Cell Death.
GL-V9 disrupts the mitochondrial homeostasis and triggers the integrated stress response by promoting the binding of cytosolic MDM2 with NDUFS1 in colorectal cancer.
Lysosomal dysfunction contributes to lead (Pb) and high-fat diet (HFD)-induced neuronal apoptosis: A link with cathepsin B.
Argininyl-Fructosyl-Galactose: A Novel Amino Acid Derivative Improves Cisplatin-induced Intestinal Toxicity via Reactive Oxygen Species-mediated Apoptosis Pathway.
Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.
Investigating C(7) modified tetrandrine derivatives for synthesis anti-hepatocellular carcinoma activity and mechanistic insights.
NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy.
Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor.
Mitochondrial DNA-driven senescence-associated secretory phenotype promotes the development of bronchopulmonary dysplasia.
Causal links between programmed cell death and hypertrophic scars: Integrative analysis of multi-omics Mendelian randomization and preliminary experimental validation.
Network Pharmacology and In Vitro Experiments Reveal the Mechanism of Agaricus blazei Murill Extract in Treating Chronic Myeloid Leukemia.
A promising novel local anesthetic for effective anesthesia in oral inflammatory conditions through reducing mitochondria-related apoptosis.
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury.
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling.
ATR Deficiency Impairs DNA Damage Repair and Accelerates Cellular Senescence in Bovine Mammary Epithelial Cells, Leading to Lactation Dysfunction.
Impact of POU3F4 mutation on cochlear development and auditory function.
N-(3-Oxododecanoyl)-Homoserine Lactone Induces Intestinal Barrier Damage in Piglets via the Lipid Raft-Mediated Apoptosis Pathway.
Enhancing KRAS G12D inhibitor sensitivity in pancreatic cancer through SHP2/PI3K pathway.
Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury.
OPTN ameliorates chondrocyte apoptosis in temporomandibular joint osteoarthritis by modulating ER-mitochondria Ca(2+) transfer.
circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes.
Exploration of the anticancer efficacy of a novel 1,3-thiazole analog in an ehrlich ascites carcinoma model: in vivo and in silico insights into hepatorenal protective potentials via the modulation of apoptosis, oxidative stress and inflammation.
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis.
Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor-Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug-Resistant Tumors.
Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy.
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA.
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
Shenghui decoction inhibits neuronal cell apoptosis to improve Alzheimer's disease through the PDE4B/cAMP/CREB signaling pathway.
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
Porphyromonas gingivalis Induces Endothelial Dysfunction Through Sirt3-Dependent CypD Acetylation.
Calycosin attenuates mitochondrial damage and pyroptosis in heart failure via the Nrf2/ROS/TXNIP pathway.
Regulation of Melatonin on AQP4 Expression in Brain of SD Newborn Rats with Bilirubin Encephalopathy and Protection Mechanism.
Activation of the cGAS-STING pathway by clofoctol through mitochondrial damage in triple-negative breast cancer.
c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy.
Crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress in apoptosis: Implications for grass carp flesh quality during cold storage.
Curcumin preserves bone health compromised by diabetes by inhibiting osteoporosis through regulation of the SIRT3/FoxO3a signalling pathway.
Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury After SAH.
OPA1 mutations in dominant optic atrophy: domain-specific defects in mitochondrial fusion and apoptotic regulation.
REGγ deficiency ameliorates hepatic ischemia and reperfusion injury in a mitochondrial p66shc dependent manner in mice.
Mechanistic study of leukopenia treatment by Qijiao shengbai Capsule via the Bcl2/Bax/CASAPSE3 pathway.
B4 suppresses lymphoma progression by inhibiting fibroblast growth factor binding protein 1 through intrinsic apoptosis.
Catecholamines-based myocardial injury after acute ischemic stroke and effects of Naoxintong capsule therapy.
NL101 synergizes with the BCL-2 inhibitor venetoclax through PI3K-dependent suppression of c-Myc in acute myeloid leukaemia.
High temperature ameliorates high-fat diet-induced obesity by promoting ceramide breakdown in skeletal muscle tissue.
Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments.
Rapid discovery of a novel "green" and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy.
miR-4645-3p attenuates podocyte injury and mitochondrial dysfunction in diabetic kidney disease by targeting Cdk5.
14-3-3-η interacts with BCL-2 to protect human endothelial progenitor cells from ox-LDL-triggered damage.
Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd.
Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy.
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC.
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.
The EPRS-ATF4-COLI pathway axis is a potential target for anaplastic thyroid carcinoma therapy.
Monotropein induces autophagy through activation of the NRF2/PINK axis, thereby alleviating sepsis-induced colonic injury.
Astaxanthin suppresses LPS-induced myocardial apoptosis by regulating PTP1B/JNK pathway in vitro.
Chemoproteomics Reveals Glaucocalyxin A Induces Mitochondria-Dependent Apoptosis of Leukemia Cells via Covalently Binding to VDAC1.
Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure.
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
Engineering exosomes from fibroblast growth factor 1 pre-conditioned adipose-derived stem cells promote ischemic skin flaps survival by activating autophagy.
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer.
BAX pores facilitate mitochondrial DNA release in wasp sting-induced acute kidney injury.
Identifying SLC2A6 as the novel protective factor in breast cancer by TP53-related genes affecting M1 macrophage infiltration.
N-acetylcysteine, a small molecule scavenger of reactive oxygen species, alleviates cardiomyocyte damage by regulating OPA1-mediated mitochondrial quality control and apoptosis in response to oxidative stress.
Targeting KPNB1 with genkwadaphnin suppresses gastric cancer progression through the Nur77-mediated signaling pathway.
USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice.
Shuangshen ningxin formula attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial function.
Licochalcone A induces mitochondria-dependent apoptosis and interacts with venetoclax in acute myeloid leukemia.
CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction.
Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
Elsinochrome A induces cell apoptosis and autophagy in photodynamic therapy.
Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Platycodin D induces apoptotic cell death through PI3K/AKT and MAPK/ERK pathways and synergizes with venetoclax in acute myeloid leukemia.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer.
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose.
Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut microbiota.
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway.
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro.
In Situ Activation of the Receptor Aggregation for Cell Apoptosis by an AI-Au Intelligent Nanomachine via Tumor Extracellular Acidity.
The protective mechanism of a novel polysaccharide from Lactobacillus-fermented Nostoc commune Vauch. on attenuating cadmium-induced kidney injury in mice.
Glucotropaeolin Promotes Apoptosis by Calcium Dysregulation and Attenuates Cell Migration with FOXM1 Suppression in Pancreatic Cancer Cells.
Toxicity of polystyrene nanoparticles for mouse ovary and cultured human granulosa cells.
PM2.5 exposure exacerbates mice thoracic aortic aneurysm and dissection by inducing smooth muscle cell apoptosis via the MAPK pathway.
Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling.
Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
MicroRNA miR-212-5p Regulates the MEK/ERK Signaling Pathway by Targeting A-Raf proto-oncogene serine/threonine-protein kinase (ARAF) to Regulate Cowshed PM(2.5)-Induced NR8383 Apoptosis.
Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress.
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy.
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Rhein Ameliorates Cognitive Impairment in an APP/PS1 Transgenic Mouse Model of Alzheimer's Disease by Relieving Oxidative Stress through Activating the SIRT1/PGC-1α Pathway.
Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice.
Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells.
Reduced Immunity Regulator MAVS Contributes to Non-Hypertrophic Cardiac Dysfunction by Disturbing Energy Metabolism and Mitochondrial Homeostasis.
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma.
Mechanism of a new photosensitizer (TBZPy) in the treatment of high-risk human papillomavirus-related diseases.
Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma.
High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma.
Comparative transcriptome and Lipidome analyses suggest a lipid droplet-specific response to heat exposure of brown adipose tissue in normal and obese mice.
Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway.
Salidroside Ameliorates Radiation Damage by Reducing Mitochondrial Oxidative Stress in the Submandibular Gland.
Rosa rugosa polysaccharide induces autophagy-mediated apoptosis in human cervical cancer cells via the PI3K/AKT/mTOR pathway.
Identification of a novel native peptide derived from 60S ribosomal protein L23a that translationally regulates p53 to reduce myocardial ischemia-reperfusion.
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.
Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells.
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
N(6)-adenomethylation of GsdmC is essential for Lgr5(+) stem cell survival to maintain normal colonic epithelial morphogenesis.
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Metformin attenuates H(2)O(2)-induced osteoblast apoptosis by regulating SIRT3 via the PI3K/AKT pathway.
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats.
Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK-eIF2α-ATF4-CHOP axis.
Nitric oxide-donating and reactive oxygen species-responsive prochelators based on 8-hydroxyquinoline as anticancer agents.
Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity.
Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration.
Croton tiglium essential oil compounds have anti-proliferative and pro-apoptotic effects in A549 lung cancer cell lines.
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway.
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore.
MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4.
SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation.
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation.
RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases.
A facile and sensitive method of quantifying glutaminase binding to its inhibitor CB-839 in tissues.
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Extracellular vesicles transmitted miR-31-5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma.
Total glucosides of paeony decreases apoptosis of hepatocytes and inhibits maturation of dendritic cells in autoimmune hepatitis.
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells.
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Mitochondrial dysfunction in high-fat diet-induced nonalcoholic fatty liver disease: The alleviating effect and its mechanism of Polygonatum kingianum.
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Artesunate induces mitochondria-mediated apoptosis of human retinoblastoma cells by upregulating Kruppel-like factor 6.
Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.
Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum.
Expression profile of the STAND protein Nwd1 in the developing and mature mouse central nervous system.
Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia.
Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation.
Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential.
DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.
Hepatic stimulator substance resists hepatic ischemia/reperfusion injury by regulating Drp1 translocation and activation.
Xiong X, Feng R, Zhang H, Ding N, Zhuang S, Tan Y, Ma H, Hong H, Luo Y
Current research in food science 2026;12:101307
Current research in food science 2026;12:101307
Ageing-Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1-Meditated Ca(2+) Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice.
Shi R, Zhang Y, Chen G, Zhang J, Liu J, Zhu H, Sun M, Duan Y
Cell proliferation 2026 May;59(5):e70120
Cell proliferation 2026 May;59(5):e70120
Mitochondrial-Disrupting Antimicrobial Peptide Nanoparticles as Precise Pyroptosis Inducers for Breast Cancer Immunotherapy.
Zhou B, Feng N, Xiao J, Huang Q, Li Q, Zhang Z, Liu Y
Advanced healthcare materials 2026 May;15(18):e71003
Advanced healthcare materials 2026 May;15(18):e71003
Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton.
Rezola Artero M, Minery A, Revel M, Armento A, Jarboui MA, Boudhabhay I, de Castro Deus M, Zarantonello A, Fleury E, Segarra L, Redissi A, Merle NS, Dragon-Durey MA, Monnot C, Sautes-Fridman C, Dimitrov JD, Fridman WH, Ueffing M, Roumenina LT
Communications biology 2026 Mar 5;9(1)
Communications biology 2026 Mar 5;9(1)
SHMT2 inhibition triggers mitochondrial apoptosis to suppress lung adenocarcinoma progression.
Chen Y, Zhang X, Pang X, Yang Y, Lu D, Zhao J, Zhu J, Du W, Gu C, Li J, Gu L, Huang JA, Liu Z, Zeng Y
Journal of translational medicine 2026 Mar 11;24(1)
Journal of translational medicine 2026 Mar 11;24(1)
Characterization of cyclotide Vdif A from Viola diffusa inhibits non-small cell lung cancer cells via regulation of CKS2.
He F, He Q, Li Y, Ren J, Tang X, Mao K, Zhangsun D, Gao B, Luo S, Wu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158146
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158146
Single-cell transcriptomic atlas of shrimp hepatopancreas reveals an endoplasmic reticulum stress-dependent immune response to Vibrio parahaemolyticus infection.
Lu L, Lei Y, Ao C, Wan B, Li Q, Wang W
Fish & shellfish immunology 2026 Jul;174:111364
Fish & shellfish immunology 2026 Jul;174:111364
γ-Glutamylcysteine Alleviates t-BHP-Induced Oxidative Damage in NIH/3T3 Fibroblasts by Promoting Nuclear Translocation of Nrf2.
Lu S, Pan Y, Xia M, Luo J, Yu W
Food science & nutrition 2026 Feb;14(2):e71574
Food science & nutrition 2026 Feb;14(2):e71574
Antitumor Cytisine-Platinum(IV) Prodrugs Potentiate Crosstalk between Endoplasmic Reticulum and Mitochondria through Calcium Overload Accompanied by Immunogenic Cell Death.
Sang RX, Wang YQ, Wu XY, Li Z, Liu XM, Xie CZ, Qiao X, Feng YK, Xu JY
Journal of medicinal chemistry 2026 Apr 9;69(7):8148-8167
Journal of medicinal chemistry 2026 Apr 9;69(7):8148-8167
GL-V9 disrupts the mitochondrial homeostasis and triggers the integrated stress response by promoting the binding of cytosolic MDM2 with NDUFS1 in colorectal cancer.
Zhang Y, Xun C, Shi C, Wang R, Gao Y, Pan D, Guo Y, Wei L
Journal of advanced research 2026 Apr 7;
Journal of advanced research 2026 Apr 7;
Lysosomal dysfunction contributes to lead (Pb) and high-fat diet (HFD)-induced neuronal apoptosis: A link with cathepsin B.
Yuan Y, Liu M, Zhai M, Wu M, Zhang W, Xin Y, Ba Y, Zhang Y, Han L, Gao L, Huang H
Neurotoxicology 2026 Apr 28;114:103462
Neurotoxicology 2026 Apr 28;114:103462
Argininyl-Fructosyl-Galactose: A Novel Amino Acid Derivative Improves Cisplatin-induced Intestinal Toxicity via Reactive Oxygen Species-mediated Apoptosis Pathway.
Liu W, Zheng YN, Jiang S, Ren S, Tang S, Zhang J, Wang Z, Li W
Current medicinal chemistry 2025;32(14):2809-2823
Current medicinal chemistry 2025;32(14):2809-2823
Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.
Li D, Duan H, Jiang Z, Zhou C, Cao C, Ni M, He L, Zhu X, Jin L, Liu W, Gu L, Li H, Liu D, Zhao X, Zhao G, Li J
Free radical biology & medicine 2025 Sep;237:270-284
Free radical biology & medicine 2025 Sep;237:270-284
Investigating C(7) modified tetrandrine derivatives for synthesis anti-hepatocellular carcinoma activity and mechanistic insights.
Jiang T, Shi L, Peng X, Zheng S, Chen Q, Lan J, Pan W
Scientific reports 2025 Sep 29;15(1):33601
Scientific reports 2025 Sep 29;15(1):33601
NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy.
Anwar MM, Meseguer S, García-Rodríguez N, Krupinska E, Sele C, Rodríguez-Jiménez A, Verma S, Sagadevan S, Ramon J, Martí R, Occhipinti A, Angione C, Ordóñez-Morán P, Knecht W, Huertas P, Juanes MA
Journal of experimental & clinical cancer research : CR 2025 Oct 17;44(1):292
Journal of experimental & clinical cancer research : CR 2025 Oct 17;44(1):292
Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor.
Zhao Q, Wu J, Yao J, Liu Z, Li C, Sun Q
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2025 Oct 15;339:126183
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2025 Oct 15;339:126183
Mitochondrial DNA-driven senescence-associated secretory phenotype promotes the development of bronchopulmonary dysplasia.
Meng Y, Shi H, Xu H, Sun Y, Wang X, Wang R, Zhang Y
American journal of physiology. Cell physiology 2025 Oct 1;329(4):C1332-C1342
American journal of physiology. Cell physiology 2025 Oct 1;329(4):C1332-C1342
Causal links between programmed cell death and hypertrophic scars: Integrative analysis of multi-omics Mendelian randomization and preliminary experimental validation.
Zhang Y, Zhao C, Zhao R
Burns : journal of the International Society for Burn Injuries 2025 Nov;51(8):107667
Burns : journal of the International Society for Burn Injuries 2025 Nov;51(8):107667
Network Pharmacology and In Vitro Experiments Reveal the Mechanism of Agaricus blazei Murill Extract in Treating Chronic Myeloid Leukemia.
Wang D, Zhu H, Ge W, Sun Y
Chemistry & biodiversity 2025 Nov;22(11):e00758
Chemistry & biodiversity 2025 Nov;22(11):e00758
A promising novel local anesthetic for effective anesthesia in oral inflammatory conditions through reducing mitochondria-related apoptosis.
Wang H, Hao Y, Gai W, Hu S, Liu W, Ma B, Shi R, Tan Y, Kang T, Hai A, Zhao Y, Tang Y, Ye L, Liu J, Liang X, Ke B
Acta pharmaceutica Sinica. B 2025 Nov;15(11):5854-5866
Acta pharmaceutica Sinica. B 2025 Nov;15(11):5854-5866
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
Tang Z, Guo C, Wen N, Jin H, Dong Y, Xu B, Ma X, Han L, Liu J
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury.
Luo A, Wang R, Gong J, Wang S, Yun C, Chen Z, Jiang Y, Liu X, Dai H, Liu H, Zheng Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2414960
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2414960
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling.
Zhang H, Liang H, Fan L, Zhu X, Ji P, Su Y, Li W, Li W
Journal of ethnopharmacology 2025 May 28;348:119863
Journal of ethnopharmacology 2025 May 28;348:119863
ATR Deficiency Impairs DNA Damage Repair and Accelerates Cellular Senescence in Bovine Mammary Epithelial Cells, Leading to Lactation Dysfunction.
Zhou Q, Geng Z, Lian S, Wang J, Wu R
Animals : an open access journal from MDPI 2025 May 14;15(10)
Animals : an open access journal from MDPI 2025 May 14;15(10)
Impact of POU3F4 mutation on cochlear development and auditory function.
Dang J, Bian P, Chen C, Chen C, Shan W, Cai L, Li Y, Tan H, Xu B, Guan M, Guo Y
Cell communication and signaling : CCS 2025 Mar 5;23(1):121
Cell communication and signaling : CCS 2025 Mar 5;23(1):121
N-(3-Oxododecanoyl)-Homoserine Lactone Induces Intestinal Barrier Damage in Piglets via the Lipid Raft-Mediated Apoptosis Pathway.
Yang Y, Zhang X, Yang J, Wu Z, Li J, Song R, Meng C, Zhu G
Veterinary sciences 2025 Mar 3;12(3)
Veterinary sciences 2025 Mar 3;12(3)
Enhancing KRAS G12D inhibitor sensitivity in pancreatic cancer through SHP2/PI3K pathway.
Hao MW, Zhang TX, Dong D, Zhou X, Gao H
Medical oncology (Northwood, London, England) 2025 Mar 27;42(5):139
Medical oncology (Northwood, London, England) 2025 Mar 27;42(5):139
Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury.
Li L, Yuan H, Li H, Cheng R, Zhou Z, Hu F, Xu L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jun;200:115428
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jun;200:115428
OPTN ameliorates chondrocyte apoptosis in temporomandibular joint osteoarthritis by modulating ER-mitochondria Ca(2+) transfer.
Zhang X, Liu H, Shi Y, Liu Z, Wang Y, Chen S, Yan X, Xu R, Ma J, Chen Q, Guo S
International immunopharmacology 2025 Jun 5;157:114796
International immunopharmacology 2025 Jun 5;157:114796
circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes.
Yu Z, Xu W, Teng Y, Li T, Guo R, Li J, Li X, Li Y, Hao Y
European journal of histochemistry : EJH 2025 Jun 17;69(3)
European journal of histochemistry : EJH 2025 Jun 17;69(3)
Exploration of the anticancer efficacy of a novel 1,3-thiazole analog in an ehrlich ascites carcinoma model: in vivo and in silico insights into hepatorenal protective potentials via the modulation of apoptosis, oxidative stress and inflammation.
El Behery M, Abo-Elmatty DM, Alsunbul M, Mohey El-Deen YI, Mohamed DI, Rashad Sindi E, Hashem MH, Al-Olayan E, Ibrahim IAA, Bamagous GA, Mali S, Saied EM
RSC advances 2025 Jun 10;15(25):20143-20167
RSC advances 2025 Jun 10;15(25):20143-20167
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
Xu F, Xia Q, Chen B, Wang R, Zhang J, Zhao X, Zhang Z, Yao Z, Zhang J, Zhou S, Li X, Chen B, Xu A, Wu L, Zhao G
Cell death and differentiation 2025 Jul;32(7):1303-1316
Cell death and differentiation 2025 Jul;32(7):1303-1316
Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis.
Zhao Z, Li J, Song N, Gao H, Liu D, Jin Z, Chen Y, Guo X, Liu Z, Yang X
Journal of ethnopharmacology 2025 Jul 24;351:119967
Journal of ethnopharmacology 2025 Jul 24;351:119967
Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor-Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug-Resistant Tumors.
Bi T, Zhao Q, Wang T, Huang R, Liu B, Liu X, Wang Y, Sun Q, Yang Y, Liu Z
Advanced healthcare materials 2025 Jan;14(2):e2403473
Advanced healthcare materials 2025 Jan;14(2):e2403473
Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy.
Pan Y, Li Y, Zhou X, Luo J, Ding Q, Pan R, Tian X
ACS applied materials & interfaces 2025 Jan 22;17(3):4608-4625
ACS applied materials & interfaces 2025 Jan 22;17(3):4608-4625
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA.
Yang J, Bu J, Liu B, Liu Y, Zhang Z, Li Z, Lu F, Zhu B, Li Y
Nature communications 2025 Jan 2;16(1):248
Nature communications 2025 Jan 2;16(1):248
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
Cheng SY, Yang YF, Wang YL, Yue ZP, Chen YZ, Wang WK, Xu ZR, Li LF, Shen H, Qi ZM, Xu CL, Liu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
Shenghui decoction inhibits neuronal cell apoptosis to improve Alzheimer's disease through the PDE4B/cAMP/CREB signaling pathway.
Gao G, Zhang X, Cui Z, Fan M, Yan Y, Huang Y, Shi Y, Ma H, Wang Z, Su Y, Zhang Z, Xie Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156366
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156366
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
Zhao Y, Yu H, Li J, Qian J, Li M, Zhang X, Wang M, Wang Y, Dong Y, You Y, Zhou Q, Gao D, Zhao Y, Liu B, Chen R, Ren Z, Wang Z, Zhang K, Cui J
Nature communications 2025 Feb 18;16(1):1736
Nature communications 2025 Feb 18;16(1):1736
Porphyromonas gingivalis Induces Endothelial Dysfunction Through Sirt3-Dependent CypD Acetylation.
Xu S, Zheng C, Huang J, Lu B, Que H, Xu L, Hou Y, He L, Fan X, Deng K, Hu R, Deng H, Wang Y
Journal of periodontal research 2025 Dec;60(12):1296-1307
Journal of periodontal research 2025 Dec;60(12):1296-1307
Calycosin attenuates mitochondrial damage and pyroptosis in heart failure via the Nrf2/ROS/TXNIP pathway.
Yuan HJ, Han QC, Yu YD, Yu H, Liu XJ, Xue YT, Li Y
International journal of molecular medicine 2025 Dec;56(6)
International journal of molecular medicine 2025 Dec;56(6)
Regulation of Melatonin on AQP4 Expression in Brain of SD Newborn Rats with Bilirubin Encephalopathy and Protection Mechanism.
Xue K, Cheng X, Qian W, Mistry H, Fan P, Hu J, Chen C, Zhang L, Vazirinasab P, Huang J, Lu W, Xu J, Zhu S, Qiu G, Ran J, Gan S
Molecular neurobiology 2025 Dec 3;63(1):239
Molecular neurobiology 2025 Dec 3;63(1):239
Activation of the cGAS-STING pathway by clofoctol through mitochondrial damage in triple-negative breast cancer.
Wang L, Zheng L, Yong X, Ding Z, Sun J, Tang Y, Tang K, Li Y, Chen J, Qi S, Hu H, Tang H
Journal of translational medicine 2025 Dec 22;24(1):70
Journal of translational medicine 2025 Dec 22;24(1):70
c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy.
Gao L, Shi Q, Sun B, Zhang X, Zheng P, Zhou L, Tian G, Li H
JACC. Basic to translational science 2025 Aug;10(8):101257
JACC. Basic to translational science 2025 Aug;10(8):101257
Crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress in apoptosis: Implications for grass carp flesh quality during cold storage.
Xiong X, Li Q, Chen L, Zhuang S, Tan Y, Hong H, Luo Y
Food chemistry 2025 Aug 30;484:144425
Food chemistry 2025 Aug 30;484:144425
Curcumin preserves bone health compromised by diabetes by inhibiting osteoporosis through regulation of the SIRT3/FoxO3a signalling pathway.
Mohammad OH, Yang S, Ji W, Ma H, Tao R
Scientific reports 2025 Aug 12;15(1):29566
Scientific reports 2025 Aug 12;15(1):29566
Inhibition of USP30 Promotes Mitophagy by Regulating Ubiquitination of MFN2 by Parkin to Attenuate Early Brain Injury After SAH.
Liu Y, Yao C, Sheng B, Zhi S, Chen X, Ding P, Zhang J, Tao Z, Li W, Zhuang Z, Mao J, Peng Z, Yan H, Jin W
Translational stroke research 2025 Apr;16(2):448-466
Translational stroke research 2025 Apr;16(2):448-466
OPA1 mutations in dominant optic atrophy: domain-specific defects in mitochondrial fusion and apoptotic regulation.
Zhang K, Zhang W, Zhang L, Hou X, Tian R, Hu Z, Yin L, Hu Z
Journal of translational medicine 2025 Apr 24;23(1):471
Journal of translational medicine 2025 Apr 24;23(1):471
REGγ deficiency ameliorates hepatic ischemia and reperfusion injury in a mitochondrial p66shc dependent manner in mice.
Guo L, Yang Q, Zhu J, Li J
Translational gastroenterology and hepatology 2024;9:62
Translational gastroenterology and hepatology 2024;9:62
Mechanistic study of leukopenia treatment by Qijiao shengbai Capsule via the Bcl2/Bax/CASAPSE3 pathway.
Jiang S, Wang P, Sun X, Zhang M, Zhang S, Cao Y, Wang Y, Liu L, Gao X
Frontiers in pharmacology 2024;15:1451553
Frontiers in pharmacology 2024;15:1451553
B4 suppresses lymphoma progression by inhibiting fibroblast growth factor binding protein 1 through intrinsic apoptosis.
Varier KM, Dan G, Li X, Liu W, Jiang F, Linghu KG, Li Y, Ben-David Y, Zhang N, Xiao C, Gajendran B, Shen X
Frontiers in pharmacology 2024;15:1408389
Frontiers in pharmacology 2024;15:1408389
Catecholamines-based myocardial injury after acute ischemic stroke and effects of Naoxintong capsule therapy.
Ouyang Y, Hu S, Chang M, Xu J, Tian G, Kong X, Liu J, Zhang D, Zhang F, Yang H, Tang L, Wu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155697
NL101 synergizes with the BCL-2 inhibitor venetoclax through PI3K-dependent suppression of c-Myc in acute myeloid leukaemia.
Lu Y, Jiang X, Li Y, Li F, Zhao M, Lin Y, Jin L, Zhuang H, Li S, Ye P, Pei R, Jin J, Jiang L
Journal of translational medicine 2024 Sep 27;22(1):867
Journal of translational medicine 2024 Sep 27;22(1):867
High temperature ameliorates high-fat diet-induced obesity by promoting ceramide breakdown in skeletal muscle tissue.
Wang Q, Chen L, Zhang J, Liu Y, Jin Y, Wu J, Ren Z
Life metabolism 2024 Oct;3(5):loae012
Life metabolism 2024 Oct;3(5):loae012
Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments.
Li X, Zheng K, Chen H, Li W
Current issues in molecular biology 2024 Oct 13;46(10):11359-11374
Current issues in molecular biology 2024 Oct 13;46(10):11359-11374
Rapid discovery of a novel "green" and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy.
Mao L, Qin Y, Fan J, Yang W, Li B, Cao L, Yuan L, Wang M, Liu B, Wang W
Journal of pharmaceutical analysis 2024 May;14(5):100923
Journal of pharmaceutical analysis 2024 May;14(5):100923
miR-4645-3p attenuates podocyte injury and mitochondrial dysfunction in diabetic kidney disease by targeting Cdk5.
Zhang Y, Xia S, Tian X, Yuan L, Gao Y, Liu D, Qi H, Wang S, Liu Z, Li Y, Zhao Z, Liu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23668
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23668
14-3-3-η interacts with BCL-2 to protect human endothelial progenitor cells from ox-LDL-triggered damage.
Zhou H, Sun X, Dai Y, Wang X, Dai Z, Li X
Cell biology international 2024 Mar;48(3):290-299
Cell biology international 2024 Mar;48(3):290-299
Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
Ma H, Suleman M, Zhang F, Cao T, Wen S, Sun D, Chen L, Jiang B, Wang Y, Lin F, Wang J, Li B, Li Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2301476
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2301476
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd.
Peng HX, Chai F, Chen KH, Huang YX, Wei GJ, Yuan H, Pang YF, Luo SH, Wang CF, Chen WC
Biological trace element research 2024 Jun;202(6):2616-2629
Biological trace element research 2024 Jun;202(6):2616-2629
Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy.
Sheng X, Wang MM, Zhang GD, Su Y, Fang HB, Yu ZH, Su Z
Bioorganic chemistry 2024 Jun;147:107325
Bioorganic chemistry 2024 Jun;147:107325
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC.
Wang L, Yang R, Kong Y, Zhou J, Chen Y, Li R, Chen C, Tang X, Chen X, Xia J, Chen X, Cheng B, Ren X
International journal of oral science 2024 Jun 17;16(1):44
International journal of oral science 2024 Jun 17;16(1):44
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.
Xiong Y, Luo J, Hong ZY, Zhu WZ, Hu A, Song BL
Journal of lipid research 2024 Jul;65(7):100579
Journal of lipid research 2024 Jul;65(7):100579
The EPRS-ATF4-COLI pathway axis is a potential target for anaplastic thyroid carcinoma therapy.
Mi L, Liu J, Zhang Y, Su A, Tang M, Xing Z, He T, Wei T, Li Z, Wu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155670
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155670
Monotropein induces autophagy through activation of the NRF2/PINK axis, thereby alleviating sepsis-induced colonic injury.
Qiang J, Yang R, Li X, Xu X, Zhou M, Ji X, Lu Y, Dong Z
International immunopharmacology 2024 Jan 25;127:111432
International immunopharmacology 2024 Jan 25;127:111432
Astaxanthin suppresses LPS-induced myocardial apoptosis by regulating PTP1B/JNK pathway in vitro.
Xie WJ, Liu M, Zhang X, Zhang YG, Jian ZH, Xiong XX
International immunopharmacology 2024 Jan 25;127:111395
International immunopharmacology 2024 Jan 25;127:111395
Chemoproteomics Reveals Glaucocalyxin A Induces Mitochondria-Dependent Apoptosis of Leukemia Cells via Covalently Binding to VDAC1.
An Y, Zhang Q, Chen Y, Xia F, Wong YK, He H, Hao M, Tian J, Zhang X, Luo P, Wang J
Advanced biology 2024 Feb;8(2):e2300538
Advanced biology 2024 Feb;8(2):e2300538
Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure.
Ruan H, Li X, Zhou L, Zheng Z, Hua R, Wang X, Wang Y, Fan Y, Guo S, Wang L, Ur Rahman S, Wang Z, Wei Y, Yu S, Zhang R, Cheng Q, Sheng J, Li X, Liu X, Yuan R, Zhang X, Chen L, Xu G, Guan Y, Nie J, Qin H, Zheng F
Science China. Life sciences 2024 Feb;67(2):360-378
Science China. Life sciences 2024 Feb;67(2):360-378
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
He Y, Zhu G, Li X, Zhou M, Guan MX
iScience 2024 Feb 16;27(2):108883
iScience 2024 Feb 16;27(2):108883
Engineering exosomes from fibroblast growth factor 1 pre-conditioned adipose-derived stem cells promote ischemic skin flaps survival by activating autophagy.
Zhang X, Jiang X, Deng H, Yu G, Yang N, Al Mamun A, Lian F, Chen T, Zhang H, Lai Y, Huang J, Xu S, Cai F, Li X, Zhou K, Xiao J
Materials today. Bio 2024 Dec;29:101314
Materials today. Bio 2024 Dec;29:101314
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer.
Su Q, Chen K, Ren J, Zhang Y, Han X, Leong SW, Wang J, Wu Q, Tu K, Sarwar A, Zhang Y
Journal of molecular medicine (Berlin, Germany) 2024 Dec;102(12):1471-1484
Journal of molecular medicine (Berlin, Germany) 2024 Dec;102(12):1471-1484
BAX pores facilitate mitochondrial DNA release in wasp sting-induced acute kidney injury.
Zhou Z, Xu L, Lv Y, Li L, Yuan H, Hu F
International immunopharmacology 2024 Dec 25;143(Pt 2):113424
International immunopharmacology 2024 Dec 25;143(Pt 2):113424
Identifying SLC2A6 as the novel protective factor in breast cancer by TP53-related genes affecting M1 macrophage infiltration.
Dai C, Man Y, Zhang L, Zhang X, Xie C, Wang S, Zhang Y, Guo Q, Zou L, Hong H, Jiang L, Shi Y
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1211-1231
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1211-1231
N-acetylcysteine, a small molecule scavenger of reactive oxygen species, alleviates cardiomyocyte damage by regulating OPA1-mediated mitochondrial quality control and apoptosis in response to oxidative stress.
Zheng J, Zhao L, Liu Y, Chen M, Guo X, Wang J
Journal of thoracic disease 2024 Aug 31;16(8):5323-5336
Journal of thoracic disease 2024 Aug 31;16(8):5323-5336
Targeting KPNB1 with genkwadaphnin suppresses gastric cancer progression through the Nur77-mediated signaling pathway.
Zhang C, Wang X, Cai G, Wang H, Liu Q, Ma S, Sun H, An Y, Miao M, Yin S, Liu P, Wang X, Wang J
European journal of pharmacology 2024 Aug 15;977:176697
European journal of pharmacology 2024 Aug 15;977:176697
USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice.
Yan M, Mei Y, Zhang T, Liu Z, Su L, Xiao Y, Zhong X, Lu Y
International journal of cardiology 2024 Aug 1;408:132149
International journal of cardiology 2024 Aug 1;408:132149
Shuangshen ningxin formula attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial function.
Liu Z, Han X, You Y, Xin G, Li L, Gao J, Meng H, Cao C, Liu J, Zhang Y, Li L, Fu J
Journal of ethnopharmacology 2024 Apr 6;323:117690
Journal of ethnopharmacology 2024 Apr 6;323:117690
Licochalcone A induces mitochondria-dependent apoptosis and interacts with venetoclax in acute myeloid leukemia.
Li Y, Zhao M, Lin Y, Jiang X, Jin L, Ye P, Lu Y, Pei R, Jiang L
European journal of pharmacology 2024 Apr 5;968:176418
European journal of pharmacology 2024 Apr 5;968:176418
CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction.
Guo P, Hu S, Liu X, He M, Li J, Ma T, Huang M, Fang Q, Wang Y
Journal of translational medicine 2024 Apr 26;22(1):390
Journal of translational medicine 2024 Apr 26;22(1):390
Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
Zhengbiao Z, Liang C, Zhi Z, Youmin P
Computational and mathematical methods in medicine 2023;2023:1318817
Computational and mathematical methods in medicine 2023;2023:1318817
Elsinochrome A induces cell apoptosis and autophagy in photodynamic therapy.
Yao Y, Pan L, Song W, Yuan Y, Yan S, Yu S, Chen S
Journal of cellular biochemistry 2023 Sep;124(9):1346-1365
Journal of cellular biochemistry 2023 Sep;124(9):1346-1365
Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Baringer SL, Lukacher AS, Palsa K, Kim H, Lippmann ES, Spiegelman VS, Simpson IA, Connor JR
Journal of neurochemistry 2023 Oct;167(2):248-261
Journal of neurochemistry 2023 Oct;167(2):248-261
Platycodin D induces apoptotic cell death through PI3K/AKT and MAPK/ERK pathways and synergizes with venetoclax in acute myeloid leukemia.
Jiang X, Lin Y, Zhao M, Li Y, Ye P, Pei R, Lu Y, Jiang L
European journal of pharmacology 2023 Oct 5;956:175957
European journal of pharmacology 2023 Oct 5;956:175957
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer.
Li W, Li D, Ma Q, Chen Y, Hu Z, Bai Y, Xie L
European journal of pharmacology 2023 Oct 15;957:176035
European journal of pharmacology 2023 Oct 15;957:176035
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Ji X, Chu L, Su D, Sun J, Song P, Sun S, Wang Y, Mu Q, Liu Y, Wan Q
iScience 2023 May 19;26(5):106656
iScience 2023 May 19;26(5):106656
Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin.
Baringer SL, Lukacher AS, Palsa K, Kim H, Lippmann ES, Spiegelman VS, Simpson IA, Connor JR
bioRxiv : the preprint server for biology 2023 May 17;
bioRxiv : the preprint server for biology 2023 May 17;
Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose.
Yuan P, Zhang Q, Fu Y, Hou Y, Gao L, Wei Y, Feng W, Zheng X
Journal of natural medicines 2023 Mar;77(2):262-275
Journal of natural medicines 2023 Mar;77(2):262-275
Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut microbiota.
Liu Y, Li H, Ren P, Che Y, Zhou J, Wang W, Yang Y, Guan L
International journal of biological macromolecules 2023 Mar 1;230:123154
International journal of biological macromolecules 2023 Mar 1;230:123154
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
Li K, Feng Z, Wang L, Ma X, Wang L, Liu K, Geng X, Peng C
Inflammation 2023 Jun;46(3):1061-1076
Inflammation 2023 Jun;46(3):1061-1076
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway.
Song QQ, Lin LP, Chen YL, Qian JC, Wei K, Su JW, Ding JH, Lu M, Liu Y, Tan RX, Hu G
Acta pharmacologica Sinica 2023 Jun;44(6):1262-1276
Acta pharmacologica Sinica 2023 Jun;44(6):1262-1276
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro.
Huang Q, Zhang Y, Jiang Y, Huang L, Liu Q, Ouyang D
Chinese journal of natural medicines 2023 Jul;21(7):516-526
Chinese journal of natural medicines 2023 Jul;21(7):516-526
In Situ Activation of the Receptor Aggregation for Cell Apoptosis by an AI-Au Intelligent Nanomachine via Tumor Extracellular Acidity.
Zhang Y, Cheng F, Liang R, Shuai XJ, Nie KH, Li J, Zeng QL, Huang CZ, Li CM
ACS applied materials & interfaces 2023 Jul 12;15(27):32262-32271
ACS applied materials & interfaces 2023 Jul 12;15(27):32262-32271
The protective mechanism of a novel polysaccharide from Lactobacillus-fermented Nostoc commune Vauch. on attenuating cadmium-induced kidney injury in mice.
Li H, Liu Y, Zhou J, Liu S, Liu Y, Yang Y, Wang W, Che Y, Inam M, Guan L
International journal of biological macromolecules 2023 Jan 31;226:1444-1454
International journal of biological macromolecules 2023 Jan 31;226:1444-1454
Glucotropaeolin Promotes Apoptosis by Calcium Dysregulation and Attenuates Cell Migration with FOXM1 Suppression in Pancreatic Cancer Cells.
Lee W, Song G, Bae H
Antioxidants (Basel, Switzerland) 2023 Jan 23;12(2)
Antioxidants (Basel, Switzerland) 2023 Jan 23;12(2)
Toxicity of polystyrene nanoparticles for mouse ovary and cultured human granulosa cells.
Huang J, Zou L, Bao M, Feng Q, Xia W, Zhu C
Ecotoxicology and environmental safety 2023 Jan 1;249:114371
Ecotoxicology and environmental safety 2023 Jan 1;249:114371
PM2.5 exposure exacerbates mice thoracic aortic aneurysm and dissection by inducing smooth muscle cell apoptosis via the MAPK pathway.
Ming Y, Zhou X, Liu G, Abudupataer M, Zhu S, Xiang B, Yin X, Lai H, Sun Y, Wang C, Li J, Zhu K
Chemosphere 2023 Feb;313:137500
Chemosphere 2023 Feb;313:137500
Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling.
Wu Y, Yang R, Lan J, Wu Y, Huang J, Fan Q, You Y, Lin H, Jiao X, Chen H, Cao C, Zhang Q
Free radical biology & medicine 2023 Feb 20;196:37-52
Free radical biology & medicine 2023 Feb 20;196:37-52
Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.
Liu Z, Fan M, Hou J, Pan S, Xu Y, Zhang H, Liu C, Hao X, Li X, Wang H
Cell death & disease 2023 Feb 20;14(2):144
Cell death & disease 2023 Feb 20;14(2):144
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
He W, Tong G, Fan H, Zhen C, Zeng L, Xue L, Chen J, Sun Z, He P
Experimental cell research 2023 Feb 15;423(2):113469
Experimental cell research 2023 Feb 15;423(2):113469
MicroRNA miR-212-5p Regulates the MEK/ERK Signaling Pathway by Targeting A-Raf proto-oncogene serine/threonine-protein kinase (ARAF) to Regulate Cowshed PM(2.5)-Induced NR8383 Apoptosis.
Sun K, Sun Y, Jia Y, Duan X, Ma Z, Zhang X, Wang L, Zhu Y, Gao Y, Basang W
Toxics 2023 Dec 3;11(12)
Toxics 2023 Dec 3;11(12)
Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress.
Chen X, Yu Z, Nong C, Xue R, Zhang M, Zhang Y, Sun L, Zhang L, Wang X
Cell biology and toxicology 2023 Aug;39(4):1753-1772
Cell biology and toxicology 2023 Aug;39(4):1753-1772
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Zhang L, Xue K, Fan P, Chen C, Hu J, Huang J, Lu W, Xu J, Xu S, Ran J, Zhu S, Gan S
Experimental eye research 2023 Apr;229:109416
Experimental eye research 2023 Apr;229:109416
Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy.
Peng S, Wang M, Zhang S, Liu N, Li Q, Kang J, Chen L, Li M, Pang K, Huang J, Lu F, Zhao D, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114200
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114200
TOM complex-independent transport pathway of myoglobin into mitochondria in C2C12 myotubes.
Koma R, Shibaguchi T, Araiso Y, Yamada T, Nonaka Y, Jue T, Masuda K
Physiological reports 2023 Apr;11(7):e15632
Physiological reports 2023 Apr;11(7):e15632
Rhein Ameliorates Cognitive Impairment in an APP/PS1 Transgenic Mouse Model of Alzheimer's Disease by Relieving Oxidative Stress through Activating the SIRT1/PGC-1α Pathway.
Yin Z, Gao D, Du K, Han C, Liu Y, Wang Y, Gao X
Oxidative medicine and cellular longevity 2022;2022:2524832
Oxidative medicine and cellular longevity 2022;2022:2524832
Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice.
Wu Y, Pi D, Chen Y, Zuo Q, Lin L, Ouyang M
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2357616
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2357616
Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells.
Hu H, Luo Z, Liu X, Huang L, Lu X, Ding R, Duan C, He Y
International journal of endocrinology 2022;2022:2009753
International journal of endocrinology 2022;2022:2009753
Reduced Immunity Regulator MAVS Contributes to Non-Hypertrophic Cardiac Dysfunction by Disturbing Energy Metabolism and Mitochondrial Homeostasis.
Wang Q, Sun Z, Cao S, Lin X, Wu M, Li Y, Yin J, Zhou W, Huang S, Zhang A, Zhang Y, Xia W, Jia Z
Frontiers in immunology 2022;13:919038
Frontiers in immunology 2022;13:919038
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Wang L, Yang Z, Wang S, Que Y, Shu X, Wu F, Liu G, Li S, Hu P, Chen H, Shi J, Tong X
British journal of pharmacology 2022 Sep;179(17):4423-4439
British journal of pharmacology 2022 Sep;179(17):4423-4439
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
Wang ZC, Niu KM, Wu YJ, Du KR, Qi LW, Zhou YB, Sun HJ
Cell death & disease 2022 Sep 26;13(9):824
Cell death & disease 2022 Sep 26;13(9):824
Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma.
Chen X, Liu Q, Chen Y, Wang L, Yang R, Zhang W, Pan X, Zhang S, Chen C, Wu T, Xia J, Cheng B, Chen X, Ren X
Molecular metabolism 2022 Nov;65:101600
Molecular metabolism 2022 Nov;65:101600
Mechanism of a new photosensitizer (TBZPy) in the treatment of high-risk human papillomavirus-related diseases.
Li Z, Xiao Z, Feng Y, Wang Q, Teng M
Photodiagnosis and photodynamic therapy 2022 Mar;37:102591
Photodiagnosis and photodynamic therapy 2022 Mar;37:102591
Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma.
Wu N, Chen S, Luo Q, Jiang Z, Wang X, Li Y, Qiu J, Yu K, Yang Y, Zhuang J
Experimental eye research 2022 Mar;216:108955
Experimental eye research 2022 Mar;216:108955
High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma.
Xu J, Su Z, Cheng X, Hu S, Wang W, Zou T, Zhou X, Song Z, Xia Y, Gao Y, Zheng Q
Cancer cell international 2022 Mar 11;22(1):115
Cancer cell international 2022 Mar 11;22(1):115
Comparative transcriptome and Lipidome analyses suggest a lipid droplet-specific response to heat exposure of brown adipose tissue in normal and obese mice.
Wang Q, Liu Y, Xu Y, Jin Y, Wu J, Ren Z
Life sciences 2022 Jun 15;299:120540
Life sciences 2022 Jun 15;299:120540
Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway.
Ma F, Deng Q, Lou H, Li J, Xu S, Wu W, Wen Q, Tang L, Wang X, Pan W
Food & function 2022 Jul 4;13(13):7062-7074
Food & function 2022 Jul 4;13(13):7062-7074
Salidroside Ameliorates Radiation Damage by Reducing Mitochondrial Oxidative Stress in the Submandibular Gland.
Sun YM, Wang XY, Zhou XR, Zhang C, Liu KJ, Zhang FY, Xiang B
Antioxidants (Basel, Switzerland) 2022 Jul 21;11(7)
Antioxidants (Basel, Switzerland) 2022 Jul 21;11(7)
Rosa rugosa polysaccharide induces autophagy-mediated apoptosis in human cervical cancer cells via the PI3K/AKT/mTOR pathway.
Liu Y, Li H, Zheng Z, Niu A, Liu S, Li W, Ren P, Liu Y, Inam M, Guan L, Ma H
International journal of biological macromolecules 2022 Jul 1;212:257-274
International journal of biological macromolecules 2022 Jul 1;212:257-274
Identification of a novel native peptide derived from 60S ribosomal protein L23a that translationally regulates p53 to reduce myocardial ischemia-reperfusion.
Yin A, Feng M, Zhang L, Cheng Z, Li Y, Qian L
Pharmacological research 2022 Jan;175:105988
Pharmacological research 2022 Jan;175:105988
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
Varier KM, Dan G, Liu W, Wu G, Xiao C, Lei H, Ling T, Jiang Y, Chen Y, Ben-David Y, Li Y, Zhang N, Gajendran B, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.
Jie W, Rui-Fen Z, Zhong-Xiang H, Yan W, Wei-Na L, Yong-Ping M, Jing S, Jing-Yi C, Wan-Hong L, Xiao-Hua H, Zhi L, Yan S
Virulence 2022 Dec;13(1):342-354
Virulence 2022 Dec;13(1):342-354
Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells.
Zhou H, Zhuang W, Huang H, Ma N, Lei J, Jin G, Wu S, Zhou S, Zhao X, Lan L, Xia H, Shangguan F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154428
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154428
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351
Redox biology 2022 Aug;54:102351
N(6)-adenomethylation of GsdmC is essential for Lgr5(+) stem cell survival to maintain normal colonic epithelial morphogenesis.
Du J, Sarkar R, Li Y, He L, Kang W, Liao W, Liu W, Nguyen T, Zhang L, Deng Z, Dougherty U, Kupfer SS, Chen M, Pekow J, Bissonnette M, He C, Li YC
Developmental cell 2022 Aug 22;57(16):1976-1994.e8
Developmental cell 2022 Aug 22;57(16):1976-1994.e8
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Chu BX, Li YN, Liu N, Yuan LX, Chen SY, Zhu YH, Wang JF
Frontiers in immunology 2021;12:757909
Frontiers in immunology 2021;12:757909
Metformin attenuates H(2)O(2)-induced osteoblast apoptosis by regulating SIRT3 via the PI3K/AKT pathway.
Yang K, Pei L, Zhou S, Tao L, Zhu Y
Experimental and therapeutic medicine 2021 Nov;22(5):1316
Experimental and therapeutic medicine 2021 Nov;22(5):1316
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
Zhang Q, Wang Z, Chen X, Qiu H, Gu Y, Wang N, Wang T, Wang Z, Ma H, Zhao Y, Zhang B
International journal of molecular sciences 2021 May 24;22(11)
International journal of molecular sciences 2021 May 24;22(11)
Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats.
Li SY, Wang CY, Zhao JJ, Long CY, Xiao YX, Tang XB, Yuan ZW, Bai YZ
Experimental cell research 2021 May 15;402(2):112574
Experimental cell research 2021 May 15;402(2):112574
Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
Li Y, Yu XJ, Xiao T, Chi HL, Zhu GQ, Kang YM
Cardiovascular toxicology 2021 Jun;21(6):472-489
Cardiovascular toxicology 2021 Jun;21(6):472-489
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.
Wang W, Li J, Tan J, Wang M, Yang J, Zhang ZM, Li C, Basnakian AG, Tang HW, Perrimon N, Zhou Q
Nature communications 2021 Jan 20;12(1):476
Nature communications 2021 Jan 20;12(1):476
LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK-eIF2α-ATF4-CHOP axis.
Yu XX, Zhu MY, Wang JR, Li H, Hu P, Qing YJ, Wang XY, Wang HZ, Wang ZY, Xu JY, Guo QL, Hui H
Acta pharmacologica Sinica 2021 Feb;42(2):290-300
Acta pharmacologica Sinica 2021 Feb;42(2):290-300
Nitric oxide-donating and reactive oxygen species-responsive prochelators based on 8-hydroxyquinoline as anticancer agents.
Zhang Y, Yang J, Meng T, Qin Y, Li T, Fu J, Yin J
European journal of medicinal chemistry 2021 Feb 15;212:113153
European journal of medicinal chemistry 2021 Feb 15;212:113153
Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity.
Chen Y, Liang J, Liang X, Chen J, Wang Y, Cao J, Sun C, Ye J, Chen Q
Food science & nutrition 2021 Apr;9(4):1860-1869
Food science & nutrition 2021 Apr;9(4):1860-1869
Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration.
Lin J, Zheng X, Zhang Z, Zhuge J, Shao Z, Huang C, Jin J, Chen X, Chen Y, Wu Y, Tian N, Sun L, Gao W, Zhou Y, Wang X, Zhang X
Osteoarthritis and cartilage 2021 Apr;29(4):579-591
Osteoarthritis and cartilage 2021 Apr;29(4):579-591
Croton tiglium essential oil compounds have anti-proliferative and pro-apoptotic effects in A549 lung cancer cell lines.
Niu QL, Sun H, Liu C, Li J, Liang CX, Zhang RR, Ge FR, Liu W
PloS one 2020;15(5):e0231437
PloS one 2020;15(5):e0231437
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Wang X, Lin Y, Zheng Y
Molecular medicine reports 2020 Sep;22(3):2318-2328
Molecular medicine reports 2020 Sep;22(3):2318-2328
Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway.
Feng D, Liu M, Liu Y, Zhao X, Sun H, Zheng X, Zhu J, Shang F
Oncology letters 2020 Oct;20(4):67
Oncology letters 2020 Oct;20(4):67
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Jiang N, Zhao H, Han Y, Li L, Xiong S, Zeng L, Xiao Y, Wei L, Xiong X, Gao P, Yang M, Liu Y, Sun L
Cell proliferation 2020 Nov;53(11):e12909
Cell proliferation 2020 Nov;53(11):e12909
Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore.
Zhao Y, Guo Y, Chen Y, Liu S, Wu N, Jia D
International journal of molecular medicine 2020 May;45(5):1514-1524
International journal of molecular medicine 2020 May;45(5):1514-1524
MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4.
Zhang X, Wang Z, Li W, Huang R, Zheng D, Bi G
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 Mar 9;30(3):523-533
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 Mar 9;30(3):523-533
SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation.
Li S, Li H, Zhang YL, Xin QL, Guan ZQ, Chen X, Zhang XA, Li XK, Xiao GF, Lozach PY, Cui J, Liu W, Zhang LK, Peng K
Cell reports 2020 Mar 31;30(13):4370-4385.e7
Cell reports 2020 Mar 31;30(13):4370-4385.e7
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, Ye Y
Stem cell research & therapy 2020 Mar 30;11(1):140
Stem cell research & therapy 2020 Mar 30;11(1):140
TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation.
Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X
The FEBS journal 2020 Jul;287(14):3088-3104
The FEBS journal 2020 Jul;287(14):3088-3104
RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases.
Reyes A, Favia P, Vidoni S, Petruzzella V, Zeviani M
PLoS genetics 2020 Jul;16(7):e1008923
PLoS genetics 2020 Jul;16(7):e1008923
A facile and sensitive method of quantifying glutaminase binding to its inhibitor CB-839 in tissues.
Chen Y, Zhao Y, Bajor DL, Wang Z, Selfridge JE
Journal of genetics and genomics = Yi chuan xue bao 2020 Jul 20;47(7):389-395
Journal of genetics and genomics = Yi chuan xue bao 2020 Jul 20;47(7):389-395
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Hua W, Li S, Luo R, Wu X, Zhang Y, Liao Z, Song Y, Wang K, Zhao K, Yang S, Yang C
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Extracellular vesicles transmitted miR-31-5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma.
He J, He J, Min L, He Y, Guan H, Wang J, Peng X
International journal of cancer 2020 Feb 15;146(4):1052-1063
International journal of cancer 2020 Feb 15;146(4):1052-1063
Total glucosides of paeony decreases apoptosis of hepatocytes and inhibits maturation of dendritic cells in autoimmune hepatitis.
Shen M, Men R, Fan X, Wang T, Huang C, Wang H, Ye T, Luo X, Yang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109911
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109911
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z
Oxidative medicine and cellular longevity 2019;2019:6521218
Oxidative medicine and cellular longevity 2019;2019:6521218
PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells.
Zhao C, He R, Shen M, Zhu F, Wang M, Liu Y, Chen H, Li X, Qin R
Frontiers in pharmacology 2019;10:968
Frontiers in pharmacology 2019;10:968
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Yang N, Li C, Li H, Liu M, Cai X, Cao F, Feng Y, Li M, Wang X
Frontiers in pharmacology 2019;10:709
Frontiers in pharmacology 2019;10:709
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.
Yao X, Jing X, Guo J, Sun K, Deng Y, Zhang Y, Guo F, Ye Y
Frontiers in pharmacology 2019;10:163
Frontiers in pharmacology 2019;10:163
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Liu T, Li X, Wu M, Qin L, Chen H, Qian P
Frontiers in microbiology 2019;10:1202
Frontiers in microbiology 2019;10:1202
Mitochondrial dysfunction in high-fat diet-induced nonalcoholic fatty liver disease: The alleviating effect and its mechanism of Polygonatum kingianum.
Yang XX, Wang X, Shi TT, Dong JC, Li FJ, Zeng LX, Yang M, Gu W, Li JP, Yu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109083
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109083
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Shen J, Wang J, Du J, Wang L, Zhou X, Chang X, Li Z, Zhai X, Zuo D, Wu Y
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Artesunate induces mitochondria-mediated apoptosis of human retinoblastoma cells by upregulating Kruppel-like factor 6.
Yang Y, Wu N, Wu Y, Chen H, Qiu J, Qian X, Zeng J, Chiu K, Gao Q, Zhuang J
Cell death & disease 2019 Nov 13;10(11):862
Cell death & disease 2019 Nov 13;10(11):862
Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.
Yao X, Zhang J, Jing X, Ye Y, Guo J, Sun K, Guo F
Pharmacological research 2019 Jan;139:314-324
Pharmacological research 2019 Jan;139:314-324
Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum.
Tang Z, Zhang Z, Zhang H, Wang Y, Zhang Y, Zhao J, Yang H, Wang Z
Cells 2019 Dec 27;9(1)
Cells 2019 Dec 27;9(1)
Expression profile of the STAND protein Nwd1 in the developing and mature mouse central nervous system.
Yamada S, Sakakibara SI
The Journal of comparative neurology 2018 Sep 1;526(13):2099-2114
The Journal of comparative neurology 2018 Sep 1;526(13):2099-2114
Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia.
Deng F, Wang S, Zhang L, Xie X, Cai S, Li H, Xie GL, Miao HL, Yang C, Liu X, Xia Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):279-292
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):279-292
Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation.
Deng F, Wang S, Cai S, Hu Z, Xu R, Wang J, Feng D, Zhang L
Oxidative medicine and cellular longevity 2017;2017:3542149
Oxidative medicine and cellular longevity 2017;2017:3542149
Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential.
Huo X, Wang C, Yu Z, Peng Y, Wang S, Feng S, Zhang S, Tian X, Sun C, Liu K, Deng S, Ma X
Journal of pineal research 2017 May;62(4)
Journal of pineal research 2017 May;62(4)
DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.
Zhang Y, Gong FL, Lu ZN, Wang HY, Cheng YN, Liu ZP, Yu LG, Zhang HH, Guo XL
The international journal of biochemistry & cell biology 2017 Dec;93:1-11
The international journal of biochemistry & cell biology 2017 Dec;93:1-11
Hepatic stimulator substance resists hepatic ischemia/reperfusion injury by regulating Drp1 translocation and activation.
Zhang C, Huang J, An W
Hepatology (Baltimore, Md.) 2017 Dec;66(6):1989-2001
Hepatology (Baltimore, Md.) 2017 Dec;66(6):1989-2001
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