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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [1009]
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- Validations
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- Product number
- HRP-60004 - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#HRP-60004, RRID:AB_2737588
- Product name
- GAPDH antibody
- Antibody type
- Monoclonal
- Description
- GAPDH antibody (Cat. #HRP-60004) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, zebrafish, plant and has been validated for the following applications: WB.
- Reactivity
- Human, Mouse, Rat, Zebrafish
- Host
- Mouse
- Conjugate
- Horseradish Peroxidase
- Isotype
- IgG
- Antibody clone number
- 1E6D9
- Vial size
- 100ul
Submitted references TL1A serves as a positive regulator to promote adipocyte differentiation.
Graphene Oxide Potentiates Induction Efficiency and Functional Maturation of Induced Mammary Epithelial Cells.
Arachidonic Acid-Induced Contraction of Smooth Muscle Is Mediated by MLC Phosphorylation in Preterm Birth.
Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the ALT pathway.
An Engineered Adeno-Associated Virus Variant Enables Efficient Gene Editing in Human T Cells.
Molecular mechanism underlying the specific RNA recognition of mitochondrial helicase DDX28 and its critical role in mitoribosomal biogenesis.
White-to-brown adipose switching promotes bladder cancer progression.
Signal Peptide Engineering and Codon Optimization to Enhance α-Gal A Activity for rAAV Gene Therapy of Fabry Disease.
Partial truncation of the C-terminal domain of PTCH1 in cancer promotes tumourigenesis by non-canonical activation of a GLI-PI3K loop.
Mechanistic Insights Into Wnt/β-Catenin Pathway Modulation in Chronic Low Back Pain and Anxiety- and Depression-Related Behaviour in Male Sprague Dawley Rats.
Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury.
Functional Characterization of a Novel GPC3 Missense Variant in Simpson-Golabi-Behmel Syndrome.
PINCH proteins orchestrate vascular mural cell homeostasis through integrated signaling and transcriptional networks.
A new mRNA antigen vaccine induces potent B and T cell responses and in vivo protection against SARS-CoV-2.
One-step generation of heritable mitochondrial DNA multiplex-engineered rats using DddA-derived cytosine base editor.
Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation.
A new mRNA antigen vaccine induces potent B and T cell responses and in vivo protection against SARS-CoV-2.
The insertion of an ATTTC repeat in an Alu element hyperactivates a neurodevelopmental enhancer in spinocerebellar ataxia type 37.
The Wnt receptor Frizzled3 (FZD3) drives aggressive phenotypes in small cell lung cancer.
Differential chromatin looping regulated by two GA-binding transcription factors creates an X-specific chromatin environment for dosage compensation.
Multifunctional Fe(3)O(4)@ZIF-8 Nanoparticles with Antibiosis and Osteogenesis for Treatment of Jaw Osteomyelitis.
Salivary pathobiont Klebsiella pneumoniae exacerbating periodontitis-related intestinal dyshomeostasis and accelerated metabolic syndrome.
Collagen-oxidized hyaluronic acid injectable self-healing hydrogel enabling sequential platelet-rich plasma release for microenvironment modulation in diabetic wound repair.
Gypenoside L inhibits oral squamous cell carcinoma progression by targeting the AKT signaling pathway.
ATGL suppresses ferroptosis in acute myeloid leukemia cells by modulating the CEBPα/SCD1 axis and induces gilteritinib resistance.
GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and behavioral abnormalities in Mecp2 and Disc1 transgenic mice.
Recurrent severe viral infection in a child with inherited complete TBK1 deficiency.
Tks4-Targeted Gene Therapy Inhibited White Adipocyte Hypertrophy in Mice.
The PI3K/AKT/NRF2 Signaling Pathway Involved in the Improvement of CUMS-Induced Depressive-like Behaviors by Apigenin.
Targeted delivery of berberine via ROS-sensitive polymersomes enhances its hepatoprotective activity in CCl(4)-intoxicated mice.
HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment.
YTHDC1-Mediated m(6)A Modification of MAGI3 mRNA Regulates Proliferation and Differentiation of Myoblasts.
Long-range deployment of tumor-antigen-specific cytotoxic T lymphocytes inhibits lung metastasis of breast cancer.
Polystyrene Nanoparticles Induce Transcriptional Repression in TM4 Sertoli Cells.
Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents.
Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis.
Exosomes Derived from BMSCs Treated with CeONPs Ameliorate Radiation-Induced Jaw Bone Injury via miR-21-5p/STAT3 Axis-Mediated Osteogenesis and ROS Scavenging.
Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy.
Human LFA-1 governs T cell immune surveillance of the skin.
Target-stabilized base editors enable robust high-fidelity RNA editing.
Detection, isolation and molecular characterization of Senecavirus A in porcine semen: Implications for control programs.
Long Noncoding RNA H19 Mediates STAT3-Dependent Activation of Keratinocytes and Fibroblasts in Systemic Sclerosis Skin.
De novo purine synthesis reprograms the macrophage inflammatory response and the immune response in sepsis.
Toxoplasma gondii effector GRA35 mediates neuronal damage via ER stress and mitochondria-associated apoptosis.
FDA-approved IMPDH inhibitors synergize with ribavirin to inhibit respiratory syncytial virus by interfering with purine de novo synthesis.
ARID1B regulates sphingolipid metabolism and myelin development via STAG2: Mechanistic insights into ARID1B-related coffin-siris syndrome.
Cystinosin regulates Na(+)/H(+) exchanger 3 trafficking and function in kidney proximal tubular cells.
Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury.
SEPHS2 loss reprograms cancer metabolism from oxidative phosphorylation to gluconeogenesis via PCK1 stabilization.
Preclinical evaluation of an mRNA vaccine developed from the first human isolate of bovine H5N1.
Tumor-Derived Alpha-1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps-CCDC25 Pathway.
FAM117A and PIGU regulate the trilogy of gastric carcinogenesis.
IL-1β-Stimulated Bone Mesenchymal Stem Cell-Derived Exosomes Mitigate Sepsis through Modulation of HMGB1/AKT Pathway and M2 Macrophage Polarization.
MUC15 acts as a tumor suppressor gene which correlates with prognosis and immune infiltration in esophageal squamous cell carcinoma.
Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development.
Fibroblast Growth Factor 20 Attenuates Colitis by Restoring Impaired Intestinal Epithelial Barrier Integrity and Modulating Macrophage Polarization via S100A9 in an NF-κB-Dependent Manner.
Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice.
Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention.
DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.
Novel USP18 mutations lead to severe interferonopathy responsive to JAK inhibitor.
SENP3/FIS1-regulated PFC neural mitochondrial fragmentation underlies the mechanism of electroacupuncture attenuating depressive behavior in CUMS mice.
Comprehensive analysis based on the ubiquitination- and deubiquitylation-related genes reveals the function of NEURL3 in esophageal squamous cell carcinoma.
Yiai Fuzheng decoction inhibits triple-negative breast cancer by remodeling the immune microenvironment.
Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis.
Shengxian decoction alleviates cyclophosphamide-induced immunosuppression via improving B cell-mediated immune responses.
BTG2-deficient mast cells remodel the tumor and tumor-draining lymph node microenvironment leading to chemotherapy resistance in breast cancer.
Polymethoxyflavones extracted from Bauhinia championii alleviate LPS-induced acute lung injury by ameliorating endoplasmic reticulum stress.
Identification of DAP3 as candidate prognosis marker and potential therapeutic target for hepatocellular carcinoma.
Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers.
Optimization of donor structure enhances the generation of cloned goats with high expression of human butyrylcholinesterase by CRISPR/Cas9.
Inactivation of Acetyl-CoA Acyltransferase 1 enhances the proliferation and motility of nasopharyngeal carcinoma cells.
Androgen receptor activation promotes tumor progression in canine and human triple negative breast cancer cell lines.
Constructing a novel mitochondrial metabolism-related genes signature to evaluate tumor immune microenvironment and predict survival of colorectal cancer.
Neutrophil-related IL1R2 gene predicts the occurrence and early progression of myocardial infarction.
Deciphering phenylalanine-derived salicylic acid biosynthesis in plants.
The spike 486 site is a key immune evasion point and a determinant of the immunogenicity of the RBD-dimer mRNA vaccine against SARS-CoV-2 variants.
sVEGFR1 up-regulation via EGR1 impairs vascular repair in SFTSV-induced hemorrhage.
m6A reader YTHDF3 elicits hypertensive effects by degrading XRCC1 mRNA in the rostral ventrolateral medulla.
Leishmania donovani infection-driven high levels of IL-10 causes hypoalbuminemia in human visceral leishmaniasis.
Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism.
CRISPR/Cas9-Mediated TARDBP Knockout Reduces Triacylglycerol Content and Key Milk Fat Metabolism Gene Expression in MAC-T Cells.
Ultrasound-activated directional and controllable nitric oxide therapy for vascular calcification repair through the modulation of eNOS/iNOS homeostasis.
METTL3 suppresses inflammatory responses by regulating SIRT1-mediated HMGB1 release in sepsis.
Hemopexin Suppresses Hepatocellular Carcinoma via TNF-α-Mediated Mitochondrial Apoptosis.
CKD-Induced Oxidative Twitch Muscle Atrophy Is Mediated by TGF- β.
CUMS stress facilitates hippocampal neural mitophagy through FIS1/MFF-mediated mitochondrial fragmentation.
Reprogramming neuroblastoma by diet-enhanced polyamine depletion.
Conserved domains of flagellin as adjuvants for an inactivated vaccine against porcine epidemic diarrhea virus.
Synthesis and anticancer studies of Ru/Ir arene complexes bearing oleanolic acid in acute promyelocytic leukemia cells.
Hinokitiol modulates Nrf2/HO-1 signaling, autophagy, and URAT1 in hyperuricemia and oxidative stress models of renal injury.
Activation of GABA transmission by clonazepam reverses the autistic-like phenotypes of the Cav3.2 knockout mice.
Wogonin modulates macrophage polarization and inflammatory signaling through the LSD1-p65 axis to alleviate osteoarthritis.
Upregulation of LINC02154 promotes esophageal cancer progression by enhancing cell cycling and epithelial-mesenchymal transition.
Targeting RelA/NLRP3/CCL3 axis mitigates microglia inflammatory response and promotes recovery after spinal cord injury.
A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution.
Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity.
ER-phagy Activation by AMFR Attenuates Cardiac Fibrosis Post-Myocardial Infarction via mTORC1 Pathway.
ILF3 downregulation by circMETTL9: Effect on traumatic brain injury-induced neuroinflammation.
The CBS/H2S axis regulates intestinal stem cell homeostasis and radiation-induced intestinal damage.
Tumor-derived RAC1(A159V) mutation promotes an immunosuppressive microenvironment that represses response to immune checkpoint inhibitor.
CD169(+) macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis.
Stage-specific roles of clonally expanded CD8(+) T cells in regulating amyloid pathology in Alzheimer's disease models.
Developing an eVLP mRNA vaccine for respiratory syncytial virus with enhanced pre-fusion targeting humoral responses.
Breaking the link between morphology and potency for mESCs.
CircCdh7 induces astrogliosis and neuroinflammation to trigger hypertensive effects in the rostral ventrolateral medulla.
Estrogen Receptor Regulates Male Satellite Cells in a Female, but Not Male, Environment.
Identification of an IL17RC missense variant in a Chinese family with multiple osteochondromas and ankylosing spondylitis.
Molecular mechanisms of synovial pathology in osteoarthritis: insights from CXCL10 and MC4R expression.
Chemotherapy-induced CA-repeat DNA fragments in breast cancer trigger antitumor immune responses.
Proteogenomic Reassessment Provides Novel Insight into the Life Cycle of Tetrahymenathermophila.
Piezo1-Mediated Calcium Flux Transfers Mechanosignal to Yes-Associated Protein to Stimulate Matrix Production in Keloid.
Spatial Transcriptional Dynamics of CD74⁺ B Cells in Tertiary Lymphoid Structures Drive Immune Evolution in Penile Squamous Cell Carcinoma.
XBP1s Mediates Cross-resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer.
A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity against Flaviviridae viruses by preventing endosomal acidification.
Tau Hypophosphorylation at Ser416 as the Early Molecular Imprint of Maternal Immune Activation: Insights from Female Mice Offspring.
KDM3A drives NSCLC proliferation and metastasis via H3K9 demethylation, EMT activation and MMP-9 upregulation.
Impact of C-Terminal PKC Phosphorylation on TRPC6 Current Kinetics.
Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis.
METTL3 and METTL14 determine human neural fate specifications.
Modeling CIC::DUX4 sarcoma reveals oncogene-mediated MHCI-dependent immune evasion.
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
10-hydroxydec-2-enoic acid alleviates post-myocardial infarction inflammation and oxidative stress by modulating the TLR4 signaling axis.
Design and Synthesis of Novel Candidate CK1δ Proteolysis Targeting Chimeras (PROTACs).
Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier.
Unveiling prognostic biomarkers and immunotherapeutic insights in prostate cancer through multi-omics and machine learning.
Nuclear SREBP2 condensates regulate the transcriptional activation of lipogenic genes and cholesterol homeostasis.
Semaglutide administration protects cardiomyocytes in db/db mice via energetic improvement and mitochondrial quality control.
The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease.
Differential Effects of Rutin and Its Aglycone Quercetin on Cytotoxicity and Chemosensitization of HCT 116 Colon Cancer Cells to Anticancer Drugs 5-Fluorouracil and Doxorubicin.
Innovative evaluation of selinexor and JQ1 synergy in leukemia therapy via C-MYC inhibition.
Hedgehog inhibitors exert anti-proliferation effects and synergistically interact with trastuzumab in HER2-positive gastric cancer models.
Linker-free PROTACs efficiently induce the degradation of oncoproteins.
Development of p300-targeting degraders with enhanced selectivity and onset of degradation.
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Systems Genetics Reveals the Gene Regulatory Mechanisms of Arrb2 in the Development of Autism Spectrum Disorders.
Anlotinib enhances the efficacy of KRAS-G12C inhibitors through c-Myc/ORC2 axis inhibition in non-small cell lung cancer.
Exposure to Sucralose and Its Effects on Testicular Damage and Male Infertility: Insights into Oxidative Stress and Autophagy.
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism.
Hyperglycaemia-induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals.
Mitochondrial NAD(+) deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm.
Application of integrated omics in aseptic loosening of prostheses after hip replacement.
Hypoxia-induced increase in sphingomyelin synthase 2 aggravates ischemic skeletal muscle inflammation.
Transgenic mice expressing the human CDHR3 receptor: A sensitive RV-C infection model for the evaluation of vaccines and therapeutics.
Improved Black Phosphorus Nanocomposite Hydrogel for Bone Defect Repairing: Mechanisms for Advancing Osteogenesis.
Microglia-Derived Interleukin-6 Triggers Astrocyte Apoptosis in the Hippocampus and Mediates Depression-Like Behavior.
Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes.
FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology.
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Structural basis for the substrate recognition and transport mechanism of the human y(+)LAT1-4F2hc transporter complex.
ZIP14 Deletion Disrupts Divalent Metal Homeostasis in Mouse Cerebrospinal Fluid.
Effects of Adalimumab on Mitochondria of Psoriatic Mesenchymal Stem Cells.
The NET-DNA-CCDC25 inhibitor di-Pal-MTO suppresses tumor progression and promotes the innate immune response.
Time-restricted feeding mitigates HFD-induced sarcopenic obesity in aging mice through improving the sensitivity of FGF21.
Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer.
Beyond Stress Granules: G3BP1 and G3BP2 Redundantly Suppress SARS-CoV-2 Infection.
Endoplasmic reticulum-anchored nonstructural proteins drive human astrovirus replication organelle formation.
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Mycobacterium tuberculosis PPE18 Protein Bodies in Insect Cells: A Candidate Tuberculosis Vaccine.
Ginsenoside Rh2 Exerts a Therapeutic Effect against Myocardial Infarction via Promoting Angiogenesis and Mitochondrial Bioenergetics.
The contribution of native protein complexes to targeted protein degradation.
Formoterol, the Most Effective Bronchodilator, Has No Anti-Inflammatory nor Metabolic Modulatory Effects in Severe Asthma Induced by Aspergillus fumigatus.
Structural Optimization of Next-Generation TRK Inhibitors against Acquired Drug Resistance Mutations for the Treatment of Solid Tumors.
Tetraspanin CD37 regulates platelet hyperreactivity and thrombosis.
Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model.
Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation.
Small molecule- and cell contact-inducible systems for controlling expression and differentiation in mouse embryonic stem cells.
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A-CELSR2 digenic mutations.
Extracellular GMFB activates the non-canonical FAS-FAF1 pathway to induce lysosomal dysfunction in early diabetic retinopathy.
P-Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating TLR4/MyD88/NF-κB-Mediated Inflammation and Oxidative Stress.
Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy.
Activation of toll-like receptor 2 promotes the expression of inflammatory mediators and cell proliferation of human polycystic kidney disease cells.
LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model.
Adipocyte CLDN5 promotes thermogenesis and energy expenditure through regulation of IL10 expression.
Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice.
Structural insights into the human system y(+)L amino acid transporter complex.
Construction and validation of acetylation-related gene signatures for immune landscape analysis and prognostication risk prediction in luminal breast cancer.
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.
Calycosin inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by downregulating early growth response 1.
Xingxiao pills suppresses lung adenocarcinoma progression by modulating lipid metabolism and inhibiting the PLA2G4A-GLI1-SOX2 Axis.
Hedyotis chrysotricha aqueous extract inhibits hepatitis B surface antigen and viral replication via hepatocyte nuclear factor 4α regulation.
Comprehensive two-dimensional primary hepatic stellate cell (HSC) membrane chromatography-based screening of anti-fibrotic components from Schisandra chinensis (Turcz.) Baill. and mechanistic insights into gomisin N against liver fibrosis.
The Expression Pattern of the Splice Variants of Coxsackievirus and Adenovirus Receptor Impacts CV-B3-Induced Encephalitis and Myocarditis in Neonatal Mice.
Novel Folate-Phenylfuran P-gp Inhibitor Conjugates for Overcoming Multidrug Resistance in MCF-7/ADR Cell.
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression.
Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway.
RNA-seq shows Angiopoietin-like 4 promotes hepatocellular carcinoma progression by inducing M2 polarization of tumor-associated macrophages.
Aberrant TCF21 upregulation in adenomyosis impairs endometrial decidualization by increasing PDE4C expression.
Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.
CHI-KAT8i5 suppresses ESCC tumor growth by inhibiting KAT8-mediated c-Myc stability.
In-depth immune profiling of a patient with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2 caused by a novel mutation in ZBTB24.
Tumor-Specific Antigen Delivery for T-cell Therapy via a pH-Sensitive Peptide Conjugate.
Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression.
Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines.
Persistent Neutrophilic Inflammation is Associated with Delayed Toxicity of Phenylarsine Oxide in Lungs.
Downregulation of MLF1 safeguards cardiomyocytes against senescence-associated chromatin opening.
Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4.
Dopamine D3 receptor mediates natural and methamphetamine rewards via regulating the expression of miR-29c in the nucleus accumbens of mice.
Novel Diagnostic Biomarker BST2 Identified by Integrated Transcriptomics Promotes the Development of Endometriosis via the TNF-α/NF-κB Signaling Pathway.
An OMV-Based Nanovaccine as Antigen Presentation Signal Enhancer for Cancer Immunotherapy.
RTN4IP1 Contributes to ESCC via Regulation of Amino Acid Transporters.
A missense variant in the SOX5 gene (c.221C > T) is associated with intellectual disability.
Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling.
Identification of the B7-H3 Interaction Partners Using a Proximity Labeling Strategy.
The structural discrepancy between the ability of fructan and arabinogalactan to cure acute pharyngitis in Hosta plantaginea (Lam.) Aschers flowers.
FGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice.
Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway.
Cystinosin is involved in Na(+)/H(+) Exchanger 3 trafficking in the proximal tubular cells: new insights in the renal Fanconi syndrome in cystinosis.
Corydalis decumbens and tetrahydropalmatrubin inhibit macrophages inflammation to relieve rheumatoid arthritis by targeting Fosl2.
β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the MAPK and STAT3 signaling pathways.
Ferroptotic Neutrophils Induce Immunosuppression and Chemoresistance in Breast Cancer.
Disruption of the gut microbiota induces the LCA/TRPV6 signalling axis, impairing desmosome junctions in vitamin A-deficient rats.
Loss of CDS1 impairs the tumorigenic characteristics of nasopharyngeal carcinoma by modulating lipid metabolism.
Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila.
Heterophyllin B alleviates diabetes-induced myocardial injury by regulating MAVS-mediated mitochondrial homeostasis.
Serum multiomics prediction of prognosis and adverse reactions to concurrent chemoradiotherapy in patients with esophageal cancer.
Single-Cell Transcriptomics Reveals ITGA2-Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis.
Cysteine-S-nitrosylation inhibits Rop5-mediated immune evasion in Toxoplasma gondii.
Loss of ADAM15 prevents necroptosis induction by partial RIPK1 degradation due to enhanced TNF-R1 surface expression and basal caspase-8 activation.
Cholestanol promotes tau pathology in a mouse model of tauopathy.
RICH1 enhances pro-inflammatory TAM infiltration in breast cancer via promoting TRIM21-mediated ubiquitination of RhoA and inhibiting STAT3 phosphorylation.
A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL.
7-Ketolithocholic Acid Exerts Anti-Renal Fibrotic Effects Through FXR-Mediated Inhibition of TGF-β/Smad and Wnt/β-Catenin Pathways.
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression.
SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1α-XBP1 Signaling Under ER Stress.
Clostridium scindens attenuates acute kidney injury by producing indole-3-acetic acid.
Nano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis.
Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation.
Exposure to submicroplastics promotes the progression of nonalcoholic fatty liver disease in ApoE-deficient mice.
From Spheroid to Sprouting: Microenvironmental Modulation Boosts Hair Follicle Organoid Morphogenesis in 3D Culture.
KW-2449 Ameliorates Cardiac Dysfunction in a Rat Model of Sepsis-Induced Cardiomyopathy.
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine.
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development.
Gastrodin Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitochondrial Fusion and Activating the AMPK-OPA1 Signaling Pathway.
GmFER1, a soybean ferritin, enhances tolerance to salt stress and root rot disease and improves soybean yield.
α6GABA(A) receptor positive allosteric modulators targeting trigeminal ganglia for preventing and aborting chronic periorbital allodynia and cephalic pain in both sexes: A mechanistic and comparative preclinical study.
Paraoxonase 3 regulates the pore-forming α subunit of the large-conductance K(+) channel.
IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.
Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation.
PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules.
Rescue of male infertility by human PRSS55 in transgenic mice establishes a contraceptive research model.
WEE1 inhibitor exerts synergistic effect with KRAS G12C inhibitor via MYBL2-RRM2 axis in KRAS(G12C)-mutant lung cancer.
Mechanisms and synergistic effects of the active components of Xanthocerais lignum in inhibiting rheumatoid arthritis through the modulation of the biological behavior of synovial cells.
BAOXIN granules reverse ferroptosis through the solute carrier family 7 member -glutathione-glutathione peroxidase 4 axis in ischemia-induced heart failure in rats.
NAD(+) Metabolism-Mediated SURF4-STING Axis Enhances T-Cell Anti-Tumor Effects in the Ovarian Cancer Microenvironment.
Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4(QTY)-Fc as a molecular trap.
The EMC acts as a chaperone for membrane proteins.
Cardamonin inhibits the growth and stemness of osteosarcoma stem cells by inducing autophagy and inhibiting the Wnt/β-catenin signaling pathway.
Interleukin-10 augments human endogenous retroviral E1B variant of cd5 in aged T cells.
Loss of TDP-43 Splicing Repression Occurs in Myonuclei of Inclusion Body Myositis Patients.
Complement Receptor 1 Is a Potential Extracerebral Factor Promoting α-Synuclein Pathology.
Transforming Growth Factor Beta2 Promotes Migration and Inhibits the Proliferation of Gastric Cancer Cells by Regulating the pSmad2/3-NDRG1 Signaling Pathway.
Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury.
A combination of alveolar type 2-specific p38α activation with a high-fat diet increases inflammatory markers in mouse lungs.
The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins.
Tianqi Yizhi Granule alleviates cognitive dysfunction and neurodegeneration in SAMP8 mice via the PKC/ERK pathway.
LINC01235 Promotes Clonal Evolution through DNA Replication Licensing-Induced Chromosomal Instability in Breast Cancer.
Persistent neutrophilic inflammation is associated with delayed toxicity of phenylarsine oxide in lungs.
Portal hypertension aggravates Helicobacter pylori induced liver injury in mice via activating pyroptosis pathway.
The deubiquitinase YOD1 suppresses tumor progression by stabilizing ZNF24 in clear cell renal carcinoma.
Cannabinoid CB(2) receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission.
Impaired unfolded protein response, BDNF and synuclein markers in postmortem dorsolateral prefrontal cortex and caudate nucleus of patients with depression and Parkinson's disease.
Mechanistic evaluation of Jiu Wei Qing Zhi Gao in non-alcoholic fatty liver disease: insights from network Pharmacology and experimental validation.
The vitamin D(3) hormone, 1,25(OH)(2)D(3), regulates fibroblast growth factor 23 (FGF23) production in human skin cells.
The FTO Mediated N6-Methyladenosine Modification of DDIT4 Regulation with Tumorigenesis and Metastasis in Prostate Cancer.
Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells.
Construction of the miRNA/Pyroptosis-Related Molecular Regulatory Axis in Abdominal Aortic Aneurysm: Evidence From Transcriptome Data Combined With Multiple Machine Learning Approaches Followed by Experiment Validation.
Ruxolitinib-based senomorphic therapy mitigates cardiomyocyte senescence in septic cardiomyopathy by inhibiting the JAK2/STAT3 signaling pathway.
PKCα Induced the Generation of Extracellular Vesicles in Activated Platelets to Promote Breast Cancer Metastasis.
Stimuli-Responsive Peptide/siRNA Nanoparticles as a Radiation Sensitizer for Glioblastoma Treatment by Co-Inhibiting RELA/P65 and EGFR.
Menaquinone-4 Alleviates Sepsis-Associated Acute Lung Injury via Activating SIRT3-p53/SLC7A11 Pathway.
CORM-3 Inhibits the Inflammatory Response of Human Periodontal Ligament Fibroblasts Stimulated by LPS and High Glucose.
Knockdown of LRP5 Promotes Proliferation and Invasion of Tongue Squamous Cell Carcinoma through Compensatory Activation of Akt Signaling.
Yinqin Qingfei granules alleviate Mycoplasma pneumoniae pneumonia via inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis.
Baitouweng decoction alleviates ulcerative colitis by regulating tryptophan metabolism through DOPA decarboxylase promotion.
FLNB overexpression promotes tumor progression and associates with immune suppression, evasion and stemness in pancreatic cancer.
Intraductal photothermal ablation: a noninvasive approach for early breast cancer treatment and prevention.
Altered expression of the Plexin-B2 system in tuberous sclerosis complex and focal cortical dysplasia IIb lesions.
Inhibition of CXCR4: A perspective on miracle fruit seed for Alzheimer's disease treatment.
Exploring the role of spinal astrocytes in the onset of hyperalgesic priming signals in acid-induced chronic muscle pain.
Targeting translocator protein protects against myocardial ischemia/reperfusion injury by alleviating mitochondrial dysfunction.
Unveiling a new strategy for PDIA1 inhibition: Integration of activity-based probes profiling and targeted degradation.
Identification of Matrine as a Kirsten rats Arcomaviral oncogene homolog inhibitor alleviating chemotherapy-induced neuropathic pain.
Multi-omics integration reveals potential stage-specific druggable targets in T-cell acute lymphoblastic leukemia.
Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
CD9 promotes TβR2-TβR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia.
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
GRP94 promotes anoikis resistance and peritoneal metastasis through YAP/TEAD1 pathway in gastric cancer.
A novel super-enhancer-related risk model for predicting prognosis and guiding personalized treatment in hepatocellular carcinoma.
Nuclear translocation of nucleotide enzyme Phosphoglucomutase 2 governs DNA damage response and anti-tumor immunity.
Cellular origin and clonal evolution of human dedifferentiated liposarcoma.
Edaravone Maintains AQP4 Polarity Via OS/MMP9/β-DG Pathway in an Experimental Intracerebral Hemorrhage Mouse Model.
Rsad2 mediates Bisphenol A-induced actin cytoskeletal disruption in mouse spermatocytes.
The high-bone-mass phenotype of novel transgenic mice with LRP5 A241T mutation.
Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer.
Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma.
Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis.
Gut Bacteroides ovatus ameliorates renal fibrosis by promoting the production of HDCA through upregulation of Clostridium scindens.
RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner.
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
m(6)A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells.
A comprehensive analysis of CEBPA on prognosis and function in uterine corpus endometrial carcinoma.
Prognostic Value and Immune Signatures of Anoikis-related Genes in Breast Cancer.
Identification of NET formation and the renoprotective effect of degraded NETs in lupus nephritis.
TNF-alpha promotes cilia elongation via mixed lineage kinases signaling in mouse fibroblasts and human RPE-1 cells.
Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke.
SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer.
POLQ knockdown inhibits proliferation, migration, and invasion by inducing cell cycle arrest in colorectal cancer.
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.
KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells.
Rab11-Rab8 cascade dynamics in primary cilia and membrane tubules.
Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage.
The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.
LncRNA GTL2 regulates myoblast proliferation and differentiation via the PKA-CREB pathway in Duolang sheep.
In-vitro evidence indicating that IL-10 causes aging-related hypoalbuminemia via JAK1/STAT3 and CEBP-β.
Endosomal actin branching, fission, and receptor recycling require FCHSD2 recruitment by MICAL-L1.
Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program.
TET3-overexpressing macrophages promote endometriosis.
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
LINC01572 promotes triple-negative breast cancer progression through EIF4A3-mediated β-catenin mRNA nuclear exportation.
Inhibition of influenza A virus and SARS-CoV-2 infection or co-infection by griffithsin and griffithsin-based bivalent entry inhibitor.
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology.
A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K/AKT/mTOR signaling pathway.
Podocyte-Specific Deletion of MCP-1 Fails to Protect against Angiotensin II- or Adriamycin-Induced Glomerular Disease.
Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation.
Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1.
Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel Disease.
In-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level.
Effects of chronic Cr and Ni co-exposure on liver inflammation and autophagy in mice by regulating the TLR4/mTOR pathway.
Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury.
PLA2G12A protects against diet-induced obesity and insulin resistance by enhancing energy expenditure and clearance of circulating triglycerides.
Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency.
Differential roles of putative arginine fingers of AAA(+) ATPases Rvb1 and Rvb2.
Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart.
Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion.
Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice.
Chemical Proteomics Reveals N(ε)-Fatty-Acylation of Septins by Rho Inactivation Domain (RID) of the Vibrio MARTX Toxin to Alter Septin Localization and Organization.
Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity.
CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.
Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids.
Mitotic Spindle Positioning (MISP) Facilitates Colorectal Cancer Progression by Forming a Complex with Opa Interacting Protein 5 (OIP5) and Activating the JAK2-STAT3 Signaling Pathway.
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Large-scale RNA-seq mining reveals ciclopirox triggers TDP-43 cryptic exons.
Roseburia intestinalis sensitizes colorectal cancer to radiotherapy through the butyrate/OR51E1/RALB axis.
Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA.
Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer.
The cGAS-Ku80 complex regulates the balance between two end joining subpathways.
miR-31-5p suppresses myocardial hypertrophy by targeting Nfatc2ip.
Targeting leucine-rich PPR motif-containing protein/LRPPRC by 5,7,4'-trimethoxyflavone suppresses esophageal squamous cell carcinoma progression.
Idebenone ameliorates statin-induced myotoxicity in atherosclerotic ApoE-/- mice by reducing oxidative stress and improving mitochondrial function.
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.
Chemical screen in zebrafish lateral line identified compounds that ameliorate neomycin-induced ototoxicity by inhibiting ferroptosis pathway.
Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periosti.
An easy-to-perform method for microvessel isolation and primary brain endothelial cell culture to study Alzheimer's disease.
Endosomal actin branching, fission and receptor recycling require FCHSD2 recruitment by MICAL-L1.
FLT3-selective PROTAC: Enhanced safety and increased synergy with Venetoclax in FLT3-ITD mutated acute myeloid leukemia.
TFAP2A downregulation mediates tumor-suppressive effect of miR-8072 in triple-negative breast cancer via inhibiting SNAI1 transcription.
Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite.
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
Downregulated CDK10 promotes cancer progression and radioresistance in lung cancer through activating the JNK/c-Jun signaling pathway.
Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain.
A novel FAM83G variant from palmoplantar keratoderma patient disrupts WNT signalling via loss of FAM83G-CK1α interaction.
Engineering an energy-dissipating hybrid tissue in vivo for obesity treatment.
miR-193b-3p and miR-346 Exert Antihypertensive Effects in the Rostral Ventrolateral Medulla.
Downregulation of Splicing Factor PTBP1 Curtails FBXO5 Expression to Promote Cellular Senescence in Lung Adenocarcinoma.
Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation.
Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency.
Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides.
CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair.
Rapid and comprehensive metabolites identification of 5-demethylnobiletin in rats using UPLC/Triple-TOF-MS/MS based on multiple mass defect filter and their neuroprotection against ferroptosis.
Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility†.
Adventitial delivery of miR-145 to treat intimal hyperplasia post vascular injuries through injectable and in-situ self-assembling peptide hydrogels.
Hypomethylating agent decitabine sensitizes diffuse large B-cell lymphoma to venetoclax.
Ceramide enhanced the hepatic glucagon response through regulation of CREB activity.
Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice.
UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.
Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape.
Bleomycin reduces Vairimorpha (Nosema) ceranae infection in honey bees with some evident host toxicity.
IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1.
Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells.
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib.
The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway.
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling.
Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis.
Characterization of immunogenic cell death regulators predicts survival and immunotherapy response in lung adenocarcinoma.
SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay.
Regulatory roles of NAMPT and NAD(+) metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment.
Herbal medicine Ninjinyoeito inhibits RANKL-induced osteoclast differentiation and bone resorption activity by regulating NF-κB and MAPK pathway.
Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy.
Hsa_circRNA_000166 accelerates breast cancer progression via the regulation of the miR-326/ELK1 and miR-330-5p/ELK1 axes.
KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.
Knockdown of nicotinamide N-methyltransferase ameliorates renal fibrosis caused by ischemia-reperfusion injury and remodels sphingosine metabolism.
Carrier frequency and incidence estimation of deficiency of adenosine deaminase 2 in the Chinese population based on massive exome sequencing data.
Design, synthesis, and biological evaluation of novel 5,7,4'-trimethoxyflavone sulfonamide-based derivatives as highly potent inhibitors of LRPPRC/STAT3/CDK1.
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicity.
Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition.
Molecular and Clinical Characterization of a Founder Mutation Causing G6PC3 Deficiency.
Activation of β3-adrenergic receptor by mirabegron prevents aortic dissection/aneurysm by promoting lymphangiogenesis in perivascular adipose tissue.
S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation.
Scalp acupuncture alleviates remote hippocampal damage in MCAO rats by inhibiting neuroinflammation: A TMT-based proteomics analysis.
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain.
Genetic risk factors for COVID-19 and influenza are largely distinct.
Haspin mediates H3.3S31 phosphorylation downstream of Aurora B in mouse embryonic stem cells.
The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence.
Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.
miR-181a expressed in the dorsal hippocampus regulates the reinstatement of cocaine CPP by targeting PRKAA1.
NADPH oxidase-dependent free radical generation and protein adduct formation in neutrophils.
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
Drug-induced senescence by aurora kinase inhibitors attenuates innate immune response of macrophages on gastric cancer organoids.
Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling.
Paired organoids from primary gastric cancer and lymphatic metastasis are useful for personalized medicine.
Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage.
Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors.
Macrocarpal B blocks the binding between the phospholipase A2 receptor and its antibodies.
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.
M2 macrophage-derived exosomes carry miR-142-3p to restore the differentiation balance of irradiated BMMSCs by targeting TGF-β1.
Coptisine inhibits neointimal hyperplasia through attenuating Pak1/Pak2 signaling in vascular smooth muscle cells without retardation of re-endothelialization.
Age-Related Gut Microbiota Transplantation Disrupts Myocardial Energy Homeostasis and Induces Oxidative Damage.
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
N6-methyladenosine-modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis.
Schisandrin A alleviates renal fibrosis by inhibiting PKCβ and oxidative stress.
Co-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis.
PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis.
Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets.
Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation.
GDF9(His209GlnfsTer6/S428T) and GDF9(Q321X/S428T) bi-allelic variants caused female subfertility with defective follicle enlargement.
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.
The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression.
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease.
Ferrostatin-1 mitigates ionizing radiation-induced intestinal injuries by inhibiting apoptosis and ferroptosis: an in vitro and in vivo study.
Electric field promotes dermal fibroblast transdifferentiation through activation of RhoA/ROCK1 pathway.
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer.
Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis.
Electroacupuncture alleviated depression-like behaviors in ventromedial prefrontal cortex of chronic unpredictable mild stress-induced rats: Increasing synaptic transmission and phosphorylating dopamine transporter.
Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation.
Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ.
hESC-Derived Epicardial Cells Promote Repair of Infarcted Hearts in Mouse and Swine.
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss.
Identification of VPS34-PI(3)P-FEN1-mediated DNA repair pathway as a potential drug target to overcome chemoresistance.
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis.
A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease.
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.
Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism.
Evaluation of the radiosensitizing effect of MEK inhibitor KZ-001 on non-small cell lung cancer cells in vitro.
Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction proteins and the TRPA1 modulation.
Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.
Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response.
Chimpanzee adenovirus-mediated multiple gene therapy for age-related macular degeneration.
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein.
Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups.
Lycorine promotes IDH1 acetylation to induce mitochondrial dynamics imbalance in colorectal cancer cells.
An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity.
Assigning functionality to cysteines by base editing of cancer dependency genes.
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer.
Towards modular engineering of cell signalling: Topographically-textured microparticles induce osteogenesis via activation of canonical hedgehog signalling.
Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8(+) T cells.
RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts.
Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti-Tumor Immunity.
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase.
ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria.
Compound 5 alleviated acute kidney injury without affecting the antitumor effect after cisplatin treatment.
Aryl hydrocarbon receptor is a tumor promoter in MYCN-amplified neuroblastoma cells through suppression of differentiation.
KZ02 enhances the radiosensitivity of BRAF-mutated CRC in vitro and in vivo.
Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells.
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Melatonin ameliorates histone modification disorders in mammalian aged oocytes by neutralizing the alkylation of HDAC1.
Gigaxonin is required for intermediate filament transport.
An A-kinase anchoring protein (ACBD3) coordinates traffic-induced PKA activation at the Golgi.
Microglial P2Y12 Signaling Contributes to Cisplatin-induced Pain Hypersensitivity via IL-18-mediated Central Sensitization in the Spinal Cord.
Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders.
Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice.
Deletion of Arrb2 Down-regulates Autophagy in the Mouse Hippocampus via Akt-mTOR Pathway Activation.
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Bmi-1 Overexpression Improves Sarcopenia Induced by 1,25(OH)(2) D(3) Deficiency and Downregulates GATA4-Dependent Rela Transcription.
Inherent Capability of Self-Assembling Nanostructures in Specific Proteasome Activation for Cancer Cell Pyroptosis.
Human MD2 deficiency-an inborn error of immunity with pleiotropic features.
Identification of novel NFKB1 and ICOS frameshift variants in patients with CVID.
Effect of dermatopontin on osteogenic differentiation of periodontal ligament stem cells.
NUSAP1 Binds ILF2 to Modulate R-Loop Accumulation and DNA Damage in Prostate Cancer.
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
The Regulation of ZIP8 by Dietary Manganese in Mice.
The Effect of Cholesterol Efflux on Endothelial Dysfunction Caused by Oxidative Stress.
CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasis.
The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma.
CD8+ T cell-Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance.
TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate.
Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinoma.
"Untargeting" autoantibodies using genome editing, a proof-of-concept study.
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.
HSPA5, as a ferroptosis regulator, may serve as a potential therapeutic for head and neck squamous cell carcinoma.
Sunitinib attenuates reactive MDSCs enhancing anti-tumor immunity in HNSCC.
Differential intracellular trafficking of extracellular vesicles in microglia and astrocytes.
Chemotherapeutic drugs-induced pyroptosis mediated by gasdermin E promotes the progression and chemoresistance of pancreatic cancer.
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice.
Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.
An In Vivo CRISPR Screen Identifies That SNRPC Promotes Triple-Negative Breast Cancer Progression.
Role of ADAM33 short isoform as a tumor suppressor in the pathogenesis of thyroid cancer via oncogenic function disruption of full-length ADAM33.
PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla.
PDZD8-mediated endoplasmic reticulum-mitochondria associations regulate sympathetic drive and blood pressure through the intervention of neuronal mitochondrial homeostasis in stress-induced hypertension.
Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.
Hierarchically Injectable Hydrogel Sequentially Delivers AntagomiR-467a-3p-Loaded and AntagomiR-874-5p-Loaded Satellite-Cell-Targeting Bioengineered Extracellular Vesicles Attenuating Sarcopenia.
Conoidin A, a Covalent Inhibitor of Peroxiredoxin 2, Reduces Growth of Glioblastoma Cells by Triggering ROS Production.
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles.
Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model.
Hepatic DKK1-driven steatosis is CD36 dependent.
p53 downregulates PD-L1 expression via miR-34a to inhibit the growth of triple-negative breast cancer cells: a potential clinical immunotherapeutic target.
De Novo Somatic Mosaicism of CYBB Caused by Intronic LINE-1 Element Insertion Resulting in Chronic Granulomatous Disease.
CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype.
The novel sustained 3-hydroxybutyrate donor poly-D-3-hydroxybutyric acid prevents inflammatory bowel disease through upregulation of regulatory T-cells.
IKKα aggravates renal fibrogenesis by positively regulating the Wnt/β-catenin pathway.
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability.
Lactate metabolism is essential in early-onset mitochondrial myopathy.
PCIF1-mediated deposition of 5'-cap N(6),2'-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection.
Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis.
Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.
Polycationic PAMAM ameliorates obesity-associated chronic inflammation and focal adiposity.
miRNA‑92a inhibits vascular smooth muscle cell phenotypic modulation and may help prevent in‑stent restenosis.
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening.
Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.
Genetic background strongly influences the transition to chronic kidney disease of adriamycin nephropathy in mice.
PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis.
BRPF1 bridges H3K4me3 and H3K23ac in human embryonic stem cells and is essential to pluripotency.
Effect of Zbed6 Single-Allele Knockout on the Growth and Development of Skeletal Muscle in Mice.
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Mitotic spindle positioning protein (MISP) deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis in mice.
The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice.
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production.
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
A novel homozygous Y140X mutation of ISG15 causes diverse type I interferonopathies in sibling patients with cutaneous lesions or recurrent parenchymal pneumonia.
METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis.
Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
GmPLP1 negatively regulates soybean resistance to high light stress by modulating photosynthetic capacity and reactive oxygen species accumulation in a blue light-dependent manner.
The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation.
BPTF Drives Gastric Cancer Resistance to EGFR Inhibitor by Epigenetically Regulating the C-MYC/PLCG1/Perk Axis.
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
CREB1 Facilitates GABAergic Neural Differentiation of Human Mesenchymal Stem Cells through BRN2 for Pain Alleviation and Locomotion Recovery after Spinal Cord Injury.
Choroid plexus mast cells drive tumor-associated hydrocephalus.
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease.
Single amino acid-based PROTACs trigger degradation of the oncogenic kinase BCR-ABL in chronic myeloid leukemia (CML).
Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin.
Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy.
Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition.
OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer.
Haspin balances the ratio of asymmetric cell division through Wnt5a and regulates cell fate decisions in mouse embryonic stem cells.
XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to -4) Using a Newly Developed DENV-3 Infectious Clone and Replicon.
Expression and function of patatin-like phospholipase domain-containing 2 in cleft palate induced by retinoic acid.
A neuron-specific Isca1 knockout rat developments multiple mitochondrial dysfunction syndromes.
Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer.
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
Conserved NIMA kinases regulate multiple steps of endocytic trafficking.
NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).
KDEL Receptor Trafficking to the Plasma Membrane Is Regulated by ACBD3 and Rab4A-GTP.
Gomisin D alleviates liver fibrosis through targeting PDGFRβ in hepatic stellate cells.
A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns.
FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.
A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model.
Syndecan-1 as an immunogene in Triple-negative breast cancer: regulation tumor-infiltrating lymphocyte in the tumor microenviroment and EMT by TGFb1/Smad pathway.
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain.
Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer.
Artemin Promotes the Migration and Invasion of Cervical Cancer Cells through AKT/mTORC1 Signaling.
Elevated FOXA1 Expression Indicates Poor Prognosis in Liver Cancer due to Its Effects on Cell Proliferation and Metastasis.
Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.
Growth Differentiation Factor 15 Regulates Oxidative Stress-Dependent Ferroptosis Post Spinal Cord Injury by Stabilizing the p62-Keap1-Nrf2 Signaling Pathway.
Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.
Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis.
Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1.
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy.
Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis.
A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C.
Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.
Ruxolitinib attenuates secondary injury after traumatic spinal cord injury.
Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy.
MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer.
Pangenomic analysis of Chinese gastric cancer.
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.
E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma.
Suppression of macrophage-mediated xenogeneic rejection by the ectopic expression of human CD177.
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho.
A non-metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11-mediated CD133 stability.
Autoregulation of H(+)/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.
Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.
Identification of SLC3A2 as a Potential Therapeutic Target of Osteoarthritis Involved in Ferroptosis by Integrating Bioinformatics, Clinical Factors and Experiments.
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome.
Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice.
Excessive activation of HOXB13/PIMREG axis promotes hepatocellular carcinoma progression and drug resistance.
Coronin2A links actin-based endosomal processes to the EHD1 fission machinery.
Genetic and Functional Identifying of Novel STAT1 Loss-of-Function Mutations in Patients with Diverse Clinical Phenotypes.
Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability.
Tp47 promoted the phagocytosis of HMC3 cells though autophagy induced by endoplamic reticlum stress.
Combined Therapy of Low-Dose Angiotensin Receptor-Neprilysin Inhibitor and Sodium-Glucose Cotransporter-2 Inhibitor Prevents Doxorubicin-Induced Cardiac Dysfunction in Rodent Model with Minimal Adverse Effects.
Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors.
Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer.
Deficiency of CD93 exacerbates inflammation-induced activation and migration of BV2 microglia by regulating the TAK1/NF-κB pathway.
CD16(+) fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition.
Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo.
Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
Defining the Skeletal Myogenic Lineage in Human Pluripotent Stem Cell-Derived Teratomas.
Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins.
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.
Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice.
Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.
The retromer complex regulates C. elegans development and mammalian ciliogenesis.
Direct targeting of amplified gene loci for proapoptotic anticancer therapy.
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.
Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.
Sexual dimorphic impacts of systemic vincristine on lower urinary tract function.
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Up-regulation of miR-335 and miR-674-3p in the rostral ventrolateral medulla contributes to stress-induced hypertension.
Pervasive translation of circular RNAs driven by short IRES-like elements.
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.
The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice.
MEK1/2 inhibitors induce class I alcohol dehydrogenase (ADH1) expression by regulating farnesoid X receptor in hepatic cell lines and C57BL/6J mouse.
Inhibiting uptake of extracellular vesicles derived from senescent bone marrow mesenchymal stem cells by muscle satellite cells attenuates sarcopenia.
Iron-regulated assembly of the cytosolic iron-sulfur cluster biogenesis machinery.
Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis.
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice.
Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.
Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.
C-type lectin domain-containing protein CLEC3A regulates proliferation, regeneration and maintenance of nucleus pulposus cells.
FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.
DSCAM-AS1 Long Non-Coding RNA Exerts Oncogenic Functions in Endometrial Adenocarcinoma via Activation of a Tumor-Promoting Transcriptome Profile.
UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity via modulating unfolded protein response.
PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1.
CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway.
Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
LRRK2 is required for CD38-mediated NAADP-Ca(2+) signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.
Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma.
Proteomic analysis of opossum Monodelphis domestica spinal cord reveals the changes of proteins related to neurodegenerative diseases during developmental period when neuroregeneration stops being possible.
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.
Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80.
The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.
Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification.
Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition.
Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice.
Effects of the Water Extract of Fermented Rice Bran on Liver Damage and Intestinal Injury in Aged Rats with High-Fat Diet Feeding.
Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.
The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2.
Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.
Hypoxic preconditioning promotes galvanotaxis of human dermal microvascular endothelial cells through NF-κB pathway.
Selective targeting of visceral adiposity by polycation nanomedicine.
Single-cell transcriptional profiling reveals heterogeneity and developmental trajectories of Ewing sarcoma.
Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR.
VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.
Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.
Genome-Wide Analysis of Circular RNAs Reveals circCHRNG Regulates Sheep Myoblast Proliferation via miR-133/SRF and MEF2A Axis.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Resveratrol activates the SIRT1/PGC-1 pathway in mice to improve synaptic-related cognitive impairment after TBI.
The DEAD-box helicase DDX3x ameliorates non-alcoholic fatty liver disease via mTORC1 signalling pathway.
VEGF promotes tendon regeneration of aged rats by inhibiting adipogenic differentiation of tendon stem/progenitor cells and promoting vascularization.
Spirulina phycocyanin extract and its active components suppress epithelial-mesenchymal transition process in endometrial cancer via targeting TGF-beta1/SMAD4 signaling pathway.
Rational Design and Optimization of m(6)A-RNA Demethylase FTO Inhibitors as Anticancer Agents.
Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.
Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity.
AKT serine/threonine kinase 2-mediated phosphorylation of fascin threonine 403 regulates esophageal cancer progression.
A functional PVA aerogel-based membrane obtaining sutureability through modified electrospinning technology and achieving promising anti-adhesion effect after cardiac surgery.
Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma.
The Role of ATF3 in Neuronal Differentiation and Development of Neuronal Networks in Opossum Postnatal Cortical Cultures.
Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via TRIM21, leading to cell death and defective myogenesis.
Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
Characteristics of the Gut Microbiome and IL-13/TGF-β1 Mediated Fibrosis in Post-Kasai Cholangitis of Biliary Atresia.
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes.
Development and Validation of a Ferroptosis-Related Gene Signature for Overall Survival Prediction in Lung Adenocarcinoma.
WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells.
Samm50 Promotes Hypertrophy by Regulating Pink1-Dependent Mitophagy Signaling in Neonatal Cardiomyocytes.
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules.
Indoleamine-2,3-Dioxygenase Activates Wnt/β-Catenin Inducing Kidney Fibrosis after Acute Kidney Injury.
JNK Signaling Pathway Mediates Fluoride-Induced Upregulation of CK1α during Enamel Formation.
Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway.
miR-708 Negatively Regulates TNFα/IL-1β Signaling by Suppressing NF-κB and Arachidonic Acid Pathways.
Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells.
Valproic Acid Induces Autism-Like Synaptic and Behavioral Deficits by Disrupting Histone Acetylation of Prefrontal Cortex ALDH1A1 in Rats.
Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release.
Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease.
Bifidobacterium infantis Maintains Genome Stability in Ulcerative Colitis via Regulating Anaphase-Promoting Complex Subunit 7.
Downregulation of SLC27A6 by DNA Hypermethylation Promotes Proliferation but Suppresses Metastasis of Nasopharyngeal Carcinoma Through Modulating Lipid Metabolism.
TAZ maintains telomere length in TNBC cells by mediating Rad51C expression.
PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
Discovery of Potent Antiallergic Agents Based on an o-Aminopyridinyl Alkynyl Scaffold.
HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1.
PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma.
A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
IKKε knockout alleviates angiotensin II-induced apoptosis and excessive autophagy in vascular smooth muscle cells by regulating the ERK1/2 pathway.
Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets.
Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.
Disrupting RhoA activity by blocking Arhgef3 expression mitigates microglia-induced neuroinflammation post spinal cord contusion.
Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss.
Effect of Metformin and Simvastatin in Inhibiting Proadipogenic Transcription Factors.
Effects of aging on the histology and biochemistry of rat tendon healing.
11βHSD2 Efficacy in Preventing Transcriptional Activation of the Mineralocorticoid Receptor by Corticosterone.
HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production.
Fzd7/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer.
Silencing TAK1 reduces MAPKs-MMP2/9 expression to reduce inflammation-driven neurohistological disruption post spinal cord injury.
Highly Conserved C-Terminal Region of Indian Hedgehog N-Fragment Contributes to Its Auto-Processing and Multimer Formation.
Analyses of key mRNAs and lncRNAs for different osteo-differentiation potentials of periodontal ligament stem cell and gingival mesenchymal stem cell.
EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function.
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.
Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation.
Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis.
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Mitochondrial activity regulates the differentiation of skin-derived mesenchymal stem cells into brown adipocytes to contribute to hypertension.
Development and Validation of High-Content Analysis for Screening HDAC6-Selective Inhibitors.
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.
A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer.
An Ultra-Stable, Oxygen-Supply Nanoprobe Emitting in Near-Infrared-II Window to Guide and Enhance Radiotherapy by Promoting Anti-Tumor Immunity.
WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression.
Downregulation of Prolactin-Induced Protein Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells.
A single amino acid substitution in PRKDC is a determinant of sensitivity to Adriamycin-induced renal injury in mouse.
Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure.
Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.
DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells.
The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer.
Perturbation of astroglial Slc38 glutamine transporters by NH(4)(+) contributes to neurophysiologic manifestations in acute liver failure.
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.
Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways.
Rice Husk Silica Liquid Protects Pancreatic β Cells from Streptozotocin-Induced Oxidative Damage.
Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE).
Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human.
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.
Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells.
Citrate regulates extracellular matrix mineralization during osteoblast differentiation in vitro.
Defining the protein and lipid constituents of tubular recycling endosomes.
GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
Lipolytic gene DAGLA is targeted by miR-223 in chicken hepatocytes.
Functional constipation induces bladder overactivity associated with upregulations of Htr2 and Trpv2 pathways.
Maternal vitamin A deficiency impairs cholinergic and nitrergic neurons, leading to gastrointestinal dysfunction in rat offspring via RARβ.
Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model.
Pyrvinium pamoate inhibits cell proliferation through ROS-mediated AKT-dependent signaling pathway in colorectal cancer.
Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.
Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors.
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
hsa‑miR‑429 targets CBX8 to promote cell apoptosis in diffuse large B‑cell lymphoma.
Halofuginone triggers a transcriptional program centered on ribosome biogenesis and function in honey bees.
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.
TTP protects against acute liver failure by regulating CCL2 and CCL5 through m6A RNA methylation.
Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells.
Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.
Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma.
2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.
HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity.
The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer.
Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors.
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer.
The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma.
Oct4 Regulates the Transition of Cancer Stem-Like Cells to Tumor Endothelial-Like Cells in Human Liver Cancer.
miR-3 Encoded by Hepatitis B Virus Downregulates PTEN Protein Expression and Promotes Cell Proliferation.
Electric field down-regulates CD9 to promote keratinocytes migration through AMPK pathway.
LRG1 promotes corneal angiogenesis and lymphangiogenesis in a corneal alkali burn mouse model.
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.
Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model.
Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis.
Total Glycosides of Cistanche deserticola Promote Neurological Function Recovery by Inducing Neurovascular Regeneration via Nrf-2/Keap-1 Pathway in MCAO/R Rats.
LncRNA CSMD1-1 promotes the progression of Hepatocellular Carcinoma by activating MYC signaling.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/β-Catenin Signaling Pathway.
Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria.
Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy via Suppression of Atrogin-1.
FAM122A Inhibits Erythroid Differentiation through GATA1.
Non-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1.
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
High salt diet may promote progression of breast tumor through eliciting immune response.
Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.
Physiology and Morphological Correlates of Excitatory Transmission are Preserved in Glutamine Transporter SN1-Depleted Mouse Frontal Cortex.
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.
Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy.
Endoplasmic Reticulum Stress Affects Cholesterol Homeostasis by Inhibiting LXRα Expression in Hepatocytes and Macrophages.
The beneficial effect of oyster peptides and oyster powder on cyclophosphamide-induced reproductive impairment in male rats: A comparative study.
Suppressor of Ty 16 promotes lung cancer malignancy and is negatively regulated by miR-1227-5p.
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
Magnesium Calcium Phosphate Cement Incorporating Citrate for Vascularized Bone Regeneration.
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer.
Knockout of mouse receptor accessory protein 6 leads to sperm function and morphology defects†.
Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA.
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.
Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles.
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage.
HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism.
Generation of a DAPK1 knockout first (conditional ready) human embryonic stem cell line (ZSSYe001-A) by CRISPR-Cas9 technology.
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.
Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity.
Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade.
Coagulation factor 2 thrombin receptor promotes malignancy in glioma under SOX2 regulation.
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis.
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway.
HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV.
Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer.
Calcium Channel α2δ1 Subunit Mediates Secondary Orofacial Hyperalgesia Through PKC-TRPA1/Gap Junction Signaling.
Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.
Glibenclamide ameliorates transplant-induced arteriosclerosis and inhibits macrophage migration and MCP-1 expression.
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.
Adenosine A(2A) receptor activation prevents DOCA-salt induced hypertensive cardiac remodeling via iBAT.
Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway.
Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes.
Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.
Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation.
Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell carcinoma metastasis by regulating Snail.
PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.
miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells.
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.
Protocol for Site-Specific Photo-Crosslinking Proteomics to Identify Protein-Protein Interactions in Mammalian Cells.
PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment.
Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
TNF‑α treatment increases DKK1 protein levels in primary osteoblasts via upregulation of DKK1 mRNA levels and downregulation of miR‑335‑5p.
Downregulation of GPR183 on infection restricts the early infection and intracellular replication of mycobacterium tuberculosis in macrophage.
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Hydroxysafflor yellow A induces autophagy in human liver cancer cells by regulating Beclin 1 and ERK expression.
STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease.
Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer.
EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation.
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
Intravaginal Administration of Human Type III Collagen-Derived Biomaterial with High Cell-Adhesion Activity to Treat Vaginal Atrophy in Rats.
Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel.
X-linked inhibitor of apoptosis protein accelerates migration by inducing epithelial-mesenchymal transition through TGF-β signaling pathway in esophageal cancer cells.
Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development.
Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL.
SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes.
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.
Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.
CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17.
Long Noncoding RNA GAS5 Acts As A Tumor Suppressor In Laryngeal Squamous Cell Carcinoma Via miR-21.
Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis.
Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion.
A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.
Nicotinic acetylcholine receptor subunit expression in the gastrocnemius and in the orbicularis oris before and after facial nerve injury in rats.
Different signalling in infarcted and non-infarcted areas of rat failing hearts: A role of necroptosis and inflammation.
Potential roles of lncRNA-Cox2 and EGR1 in regulating epidural fibrosis following laminectomy.
Regulation of the Metal Transporters ZIP14 and ZnT10 by Manganese Intake in Mice.
miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.
Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress.
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
Increased miRNA-518b inhibits trophoblast migration and angiogenesis by targeting EGR1 in early embryonic arrest†.
Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer.
Analyses of epithelial Na(+) channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating.
Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
The mTOR-RUNX1 pathway regulates DC-SIGN expression in renal tubular epithelial cells.
Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane.
The role of ZBTB38 in promoting migration and invasive growth of bladder cancer cells.
Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration.
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.
Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop.
Gα(i2) Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination.
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14.
Programmable RNA-Guided RNA Effector Proteins Built from Human Parts.
Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
Thermoregulation via Temperature-Dependent PGD(2) Production in Mouse Preoptic Area.
MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.
Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism.
Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes.
Spinal Serotonin 1A Receptor Contributes to the Analgesia of Acupoint Catgut Embedding by Inhibiting Phosphorylation of the N-Methyl-d-Aspartate Receptor GluN1 Subunit in Complete Freund's Adjuvant-Induced Inflammatory Pain in Rats.
Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition.
PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.
Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway.
Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells.
Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs.
MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.
Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells.
Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.
Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.
Rutin promotes the formation and osteogenic differentiation of human periodontal ligament stem cell sheets in vitro.
A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability.
Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery.
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription.
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.
Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA) Requires Death Receptor Fas, in Addition to LFA-1, To Trigger Cell Death in T Lymphocytes.
Palmitoylation is required for TNF-R1 signaling.
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Mutations in topoisomerase IIβ result in a B cell immunodeficiency.
CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.
BP‑1‑102 exerts an antitumor effect on the AGS human gastric cancer cell line through modulating the STAT3 and MAPK signaling pathways.
Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production.
miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
FEZF1 is an Independent Predictive Factor for Recurrence and Promotes Cell Proliferation and Migration in Cervical Cancer.
Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer.
Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.
Decrease of Perivascular Adipose Tissue Browning Is Associated With Vascular Dysfunction in Spontaneous Hypertensive Rats During Aging.
Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A.
IMP/GTP balance modulates cytoophidium assembly and IMPDH activity.
The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer.
m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
A(2A) Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21.
Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors.
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways.
Loss of miR-146b-3p Inhibits Perivascular Adipocyte Browning with Cold Exposure During Aging.
Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning.
Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance.
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.
hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1.
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.
miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.
Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9.
Elevated CRB3 expression suppresses breast cancer stemness by inhibiting β-catenin signalling to restore tamoxifen sensitivity.
Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.
mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways.
Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea.
Tumor necrosis factor-alpha inhibits osteogenic differentiation of pre-osteoblasts by downregulation of EphB4 signaling via activated nuclear factor-kappaB signaling pathway.
CD10(+)GPR77(+) Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness.
Interleukin-6 and insulin-like growth factor-1 synergistically promote the progression of NSCLC.
Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway.
β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming.
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
An In Vitro Comparative Study of Multisource Derived Human Mesenchymal Stem Cells for Bone Tissue Engineering.
Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats.
High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer.
AmotP130 regulates Rho GTPase and decreases breast cancer cell mobility.
The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.
A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family.
Long non-coding RNA NEAT1 regulates permeability of the blood-tumor barrier via miR-181d-5p-mediated expression changes in ZO-1, occludin, and claudin-5.
miRNA-346 promotes proliferation, migration and invasion in liver cancer.
Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting.
Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth.
Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice.
p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.
The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis.
Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.
Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease.
Transducin (β)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway.
Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation.
Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP.
Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.
MTA1 promotes epithelial to mesenchymal transition and metastasis in non-small-cell lung cancer.
Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.
Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.
Correspondence: Assessment of learning, memory and attention in developmental neurotoxicology.
Lipid droplet biology and evolution illuminated by the characterization of a novel perilipin in teleost fish.
Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway.
Bisphenol a induces autophagy and apoptosis concurrently involving the Akt/mTOR pathway in testes of pubertal SD rats.
N-acetylcysteine ameliorates repetitive/stereotypic behavior due to its antioxidant properties without activation of the canonical Wnt pathway in a valproic acid-induced rat model of autism.
Blocking the recruitment of naive CD4(+) T cells reverses immunosuppression in breast cancer.
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin.
Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.
Electroacupuncture Promotes Remyelination after Cuprizone Treatment by Enhancing Myelin Debris Clearance.
Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice.
Keap1 hypomorphism protects against ischemic and obstructive kidney disease.
Eupolyphaga sinensis Walker Ethanol Extract Suppresses Cell Growth and Invasion in Human Breast Cancer Cells.
Recombinant adeno-associated virus-delivered anginex inhibits angiogenesis and growth of HUVECs by regulating the Akt, JNK and NF-κB signaling pathways.
System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.
Constitutive translation of human α-synuclein is mediated by the 5'-untranslated region.
Downregulation of VEGF and upregulation of TL1A expression induce HUVEC apoptosis in response to high glucose stimuli.
c-Myc plays a key role in TADs-induced apoptosis and cell cycle arrest in human hepatocellular carcinoma cells.
Pigment Epithelium-Derived Factor Induces Endothelial Barrier Dysfunction via p38/MAPK Phosphorylation.
miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.
Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma.
Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.
Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma.
Elabela-apelin receptor signaling pathway is functional in mammalian systems.
Momordica cochinchinensis seed extracts suppress migration and invasion of human breast cancer ZR-75-30 cells via down-regulating MMP-2 and MMP-9.
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.
Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.
Chang Z, Wang Q, Zhai Y, Li K, Zheng X, Wang Y, Zhao D
PloS one 2026;21(2):e0343036
PloS one 2026;21(2):e0343036
Graphene Oxide Potentiates Induction Efficiency and Functional Maturation of Induced Mammary Epithelial Cells.
Lei Z, Sun Z, Deng S, Wang G, Liu Q, Huang B, Zhang D
International journal of nanomedicine 2026;21:560553
International journal of nanomedicine 2026;21:560553
Arachidonic Acid-Induced Contraction of Smooth Muscle Is Mediated by MLC Phosphorylation in Preterm Birth.
Chen X, Chen J, Qiu J, Yan Y, Zhang R
Journal of pregnancy 2026;2026(1):e8266780
Journal of pregnancy 2026;2026(1):e8266780
Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the ALT pathway.
Tsai CT, Gaela VM, Hsia HY, Huang YC, Shen YL, Chen LY
The EMBO journal 2026 May;45(10):3444-3470
The EMBO journal 2026 May;45(10):3444-3470
An Engineered Adeno-Associated Virus Variant Enables Efficient Gene Editing in Human T Cells.
Leng M, Gan C, Zheng Z, He S, Liu Y, Zhou L, Cheng R, Zhou J, Xiao L, Ye J, Chen Z, Xu L, Valencia CA, Chow HY, Zhang Y, Dong B
Human gene therapy 2026 May;37(9-10):425-441
Human gene therapy 2026 May;37(9-10):425-441
Molecular mechanism underlying the specific RNA recognition of mitochondrial helicase DDX28 and its critical role in mitoribosomal biogenesis.
Cui J, Li M, Wang L, Li F, Ruan K, Lv M, Shi Y
Structure (London, England : 1993) 2026 May 7;34(5):853-869.e6
Structure (London, England : 1993) 2026 May 7;34(5):853-869.e6
White-to-brown adipose switching promotes bladder cancer progression.
Gao M, Li C, Li W, Xie J, Long J, Luo M, Hu J, Lai C, Lan T, Zhu D, Zhong W, He W
Neoplasia (New York, N.Y.) 2026 Mar;73:101282
Neoplasia (New York, N.Y.) 2026 Mar;73:101282
Signal Peptide Engineering and Codon Optimization to Enhance α-Gal A Activity for rAAV Gene Therapy of Fabry Disease.
He S, Yang L, Wan K, Zheng Z, Leng M, Gan C, Liu Y, Xiao L, Ye J, Chen Z, Zhou J, Valencia CA, Abuammah A, Chow HY, Dong B, Chen Y
Journal of inherited metabolic disease 2026 Mar;49(2):e70168
Journal of inherited metabolic disease 2026 Mar;49(2):e70168
Partial truncation of the C-terminal domain of PTCH1 in cancer promotes tumourigenesis by non-canonical activation of a GLI-PI3K loop.
Caballero-Ruiz B, Bordone R, Coni S, Gkotsi DS, Gonzalez E, Canettieri G, Riobo-Del Galdo NA
Oncogene 2026 Mar;45(11):1013-1025
Oncogene 2026 Mar;45(11):1013-1025
Mechanistic Insights Into Wnt/β-Catenin Pathway Modulation in Chronic Low Back Pain and Anxiety- and Depression-Related Behaviour in Male Sprague Dawley Rats.
Xu J, Lin Y, Wu Z, Zhu Y, Jiang X, Jing L, Wang K, Zhang J
European journal of pain (London, England) 2026 Mar;30(3):e70245
European journal of pain (London, England) 2026 Mar;30(3):e70245
Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury.
Chen Y, Zhang XW, Zhao MM, Li L, Liu Y, Wei TT, Yu W, Han B, Liu ZP, Zeng KW
Journal of Asian natural products research 2026 Mar;28(3):469-490
Journal of Asian natural products research 2026 Mar;28(3):469-490
Functional Characterization of a Novel GPC3 Missense Variant in Simpson-Golabi-Behmel Syndrome.
Zhao T, Allan K, Taylor J, Thorburn DR, White SM, Tan TY, Christodoulou J, Tan NB, Stroud DA
American journal of medical genetics. Part A 2026 Mar;200(3):632-641
American journal of medical genetics. Part A 2026 Mar;200(3):632-641
PINCH proteins orchestrate vascular mural cell homeostasis through integrated signaling and transcriptional networks.
Wang C, Jin Y, Xin Y, Xing Q, Zhu H, Zou Q, Yan J, Luo L, Liang X, Sun Y, Liu Z
Angiogenesis 2026 Mar 8;29(2)
Angiogenesis 2026 Mar 8;29(2)
A new mRNA antigen vaccine induces potent B and T cell responses and in vivo protection against SARS-CoV-2.
Wen J, Moon J, Tucciarone L, Bu TH, Sun AY, Miller R, Timis J, Wu L, Smith DM, Shresta S, Gaulton KJ, Rana TM
bioRxiv : the preprint server for biology 2026 Mar 3;
bioRxiv : the preprint server for biology 2026 Mar 3;
One-step generation of heritable mitochondrial DNA multiplex-engineered rats using DddA-derived cytosine base editor.
Zhang X, Li K, Tan L, Chen W, Gao S, Liu C, Pan S, He J, Liu N, Wan G, Dong W, Kong W, Shen B, Qi X, Ma Y
Animal models and experimental medicine 2026 Mar 27;
Animal models and experimental medicine 2026 Mar 27;
Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation.
Postlmayr A, Sanchez Bergman A, Torrejon Diaz J, Ciraulo B, Yan S, Hofmann N, Carbajal S, Dobler R, Machaalani C, Schönholzer MT, Priego Gonzalez L, De Micheli AJ, Berenjeno-Correa E, Baroncini L, Grotzer MA, Tabori U, Hawkins C, Ayrault O, Zuckermann M, Baumgartner M, Guerreiro Stücklin AS
Cell reports 2026 Mar 24;45(3):117046
Cell reports 2026 Mar 24;45(3):117046
A new mRNA antigen vaccine induces potent B and T cell responses and in vivo protection against SARS-CoV-2.
Wen J, Moon J, Tucciarone L, Bu TH, Sun AY, Miller R, Timis J, Wu L, Smith DM, Shresta S, Gaulton KJ, Rana TM
NPJ vaccines 2026 Mar 24;11(1)
NPJ vaccines 2026 Mar 24;11(1)
The insertion of an ATTTC repeat in an Alu element hyperactivates a neurodevelopmental enhancer in spinocerebellar ataxia type 37.
Loureiro JR, Castro AF, Figueiredo AS, Eufrásio A, Dhingra A, Galhardo M, Marcelino H, Rodrigues CC, Sampaio P, Azevedo M, Sousa M, Dória S, Rizzu P, Heutink P, Bessa J, Silveira I
Cell reports 2026 Mar 22;45(4):117146
Cell reports 2026 Mar 22;45(4):117146
The Wnt receptor Frizzled3 (FZD3) drives aggressive phenotypes in small cell lung cancer.
Lu M, Zhu X, Wang C, Hou J, Guo J, Zhao J, Qin Z, Wu J, Cao X, Zhang T, Wang D, Ma T
Respiratory research 2026 Mar 21;27(1)
Respiratory research 2026 Mar 21;27(1)
Differential chromatin looping regulated by two GA-binding transcription factors creates an X-specific chromatin environment for dosage compensation.
Aguilera J, Cortez K, Alonzo LCS, Aldana M, Aragon A, Gray C, Woodman-Sousa M, Grive KJ, Ray M, Larschan E
bioRxiv : the preprint server for biology 2026 Mar 14;
bioRxiv : the preprint server for biology 2026 Mar 14;
Multifunctional Fe(3)O(4)@ZIF-8 Nanoparticles with Antibiosis and Osteogenesis for Treatment of Jaw Osteomyelitis.
Li H, Zhang Z, Wang Y, Mou T, Tian J, Huang C, Zhao L, Ge Z, Wang D, Li C, Wang J, Zheng Y, Tian L, Zong C
Pharmaceutics 2026 Mar 13;18(3)
Pharmaceutics 2026 Mar 13;18(3)
Salivary pathobiont Klebsiella pneumoniae exacerbating periodontitis-related intestinal dyshomeostasis and accelerated metabolic syndrome.
Lyu J, Wu M, Wei W, Li J, Xiong K, Shen X, Gao X, Yang J, Li M, Tang B
Molecular immunology 2026 Jun;194:13-29
Molecular immunology 2026 Jun;194:13-29
Collagen-oxidized hyaluronic acid injectable self-healing hydrogel enabling sequential platelet-rich plasma release for microenvironment modulation in diabetic wound repair.
Tan B, Chen L, Feng T, Swamiappan S, Zhang X, Lai Z, Yang Y, Chen S, Peng X, Zhou H
Biomaterials advances 2026 Jun;183:214777
Biomaterials advances 2026 Jun;183:214777
Gypenoside L inhibits oral squamous cell carcinoma progression by targeting the AKT signaling pathway.
Lai DY, Chen Y, Lan T, Zheng DL, Lu YG, Gan RH
Bioorganic chemistry 2026 Jan;168:109303
Bioorganic chemistry 2026 Jan;168:109303
ATGL suppresses ferroptosis in acute myeloid leukemia cells by modulating the CEBPα/SCD1 axis and induces gilteritinib resistance.
Yuan S, Zhou Y, Xiao W, Liu N, Zhang P, Zhang Y, Deng J, Fang L, Zhang X, Lou S
Cell death & disease 2026 Jan 9;17(1):171
Cell death & disease 2026 Jan 9;17(1):171
GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and behavioral abnormalities in Mecp2 and Disc1 transgenic mice.
Ge Y, Tian T, Li B, Axerio-Cillies P, Chen W, Qin X, Zhao M, Sun QC, Li J, Floresco SB, Liu L, Yang X, Wang YT
Science advances 2026 Jan 9;12(2):eady3891
Science advances 2026 Jan 9;12(2):eady3891
Recurrent severe viral infection in a child with inherited complete TBK1 deficiency.
Kilic SS, Zhao S, Liu Z, Karali Y, Yalcin K, Bodansky A, Chakravarty D, Wilson M, Casanova JL, Zhang SY
Journal of human immunity 2026 Jan 5;2(1):e20250058
Journal of human immunity 2026 Jan 5;2(1):e20250058
Tks4-Targeted Gene Therapy Inhibited White Adipocyte Hypertrophy in Mice.
Tian M, Deng J, Hong Y, Liu R, Li S, He X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Jan 31;40(2):e71486
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Jan 31;40(2):e71486
The PI3K/AKT/NRF2 Signaling Pathway Involved in the Improvement of CUMS-Induced Depressive-like Behaviors by Apigenin.
Wu L, Ge H, Li C, Huang J, Sun L, Xie Y, Xiao L, Wang G
Pharmaceuticals (Basel, Switzerland) 2026 Jan 23;19(2)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 23;19(2)
Targeted delivery of berberine via ROS-sensitive polymersomes enhances its hepatoprotective activity in CCl(4)-intoxicated mice.
Suman I, Klepac D, Vragović M, Križan H, Jäger E, Jäger A, Pavlova E, Hrubý M, Domitrović R
Nanoscale advances 2026 Jan 20;8(2):595-611
Nanoscale advances 2026 Jan 20;8(2):595-611
HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment.
Cartwright TN, Nakarakanti NK, Dunbar K, Fulcher LJ, Bader S, Wood NT, Macartney TJ, Sapkota GP
iScience 2026 Jan 16;29(1):114417
iScience 2026 Jan 16;29(1):114417
YTHDC1-Mediated m(6)A Modification of MAGI3 mRNA Regulates Proliferation and Differentiation of Myoblasts.
Chen Q, He S, Xue X, Zhang W, Li H, He X, Pu Y, Ma Y, Jiang L, Zhao Y, Zhao Q
Journal of agricultural and food chemistry 2026 Jan 14;74(1):1804-1818
Journal of agricultural and food chemistry 2026 Jan 14;74(1):1804-1818
Long-range deployment of tumor-antigen-specific cytotoxic T lymphocytes inhibits lung metastasis of breast cancer.
Xing Y, Zhou Y, Wang R, Chen J, Yang L, Meng X, Wang J, Ouyang Q, Zhao J, Chen F, Saw PE, Fan J, Huang JD, Wu W, Liu Q, Song E, Huang D
Developmental cell 2026 Jan 14;61(1):117-132.e10
Developmental cell 2026 Jan 14;61(1):117-132.e10
Polystyrene Nanoparticles Induce Transcriptional Repression in TM4 Sertoli Cells.
Huang X, He K, Jiang Y, Yang C, Liu X, Shen Q, Liu Y, Fan J, Wu J, Ruan H, Yang J, Hong Y
Journal of applied toxicology : JAT 2026 Feb;46(2):697-707
Journal of applied toxicology : JAT 2026 Feb;46(2):697-707
Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents.
Liu XA, Aguirre CA, Yang Q, Ren J, Wang L, Ju F, Guo H, Wang J, Liu L, Li Z, He J, Xu Z, Shi C, Cintron-Colon R, Michel T, Wood M, Margetts AV, Pollock TA, Vilca SJ, Tuesta LM, Di Angelantonio S, Basilico B, De Stefano ME, Xia J, Wei P, Li S, Yang X, Wang L, Delorme-Walker VD, Marcondes MCG, Parsons L, Conti B, Chen Z
Molecular psychiatry 2026 Feb;31(2):622-634
Molecular psychiatry 2026 Feb;31(2):622-634
Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis.
Lv H, Huang G, Li H, Liang H, Peng H, Wu K, Chen W, Zhang D, Ma K, Du Y, Luo S, Zhou Y, Mao H, Chen W, Chen T, Zhou Y, Liu Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e19981
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(12):e19981
Exosomes Derived from BMSCs Treated with CeONPs Ameliorate Radiation-Induced Jaw Bone Injury via miR-21-5p/STAT3 Axis-Mediated Osteogenesis and ROS Scavenging.
Zhang Z, Li H, Huang C, Mou T, Tian J, Ge Z, Zhao L, Wang D, Li C, Dai T, Zong C, Tian L
Pharmaceutics 2026 Feb 9;18(2)
Pharmaceutics 2026 Feb 9;18(2)
Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy.
Xu Y, Zhang X, Han X, Huang H, Meng C, Yang Y, Sheng T, Ren E, Shi J, He K, Cen D, Zhao P, Fang W, Li H, Zhang Y, Cai X, Liu F, Yu J, Gu Z
Cell 2026 Feb 5;189(3):872-886.e23
Cell 2026 Feb 5;189(3):872-886.e23
Human LFA-1 governs T cell immune surveillance of the skin.
Yatim A, Youssefian L, Idani A, Mourelatos H, Alipour Olyaei N, Habibi L, Peel JN, Gaballa M, Kim C, Lee D, Le Floc'h C, Chan YH, Martin-Fernandez M, Pelletier L, Nakajima K, Fayand A, Momenilandi M, Seeleuthner Y, Chaldebas M, Saeidian AH, Mahmoudi H, Nikbakht N, Deswarte C, Kerrouche N, Sahel H, Parvaneh N, Tamizifar B, Sherkat R, Chanal J, Firooz A, Alizadeh Z, Lorenzo-Diaz L, Mariaggi AA, Ogishi M, Diep A, Hammadi B, Kerrouche N, Rinchai D, Sedighzadeh S, Mehrjooy S, Akrami SM, Lenormand C, Radosavljevic M, Rosain J, Zhang SY, Boisson B, Zhang P, Boisson-Dupuis S, Krueger JG, Prétet JL, Waterboer T, Pourpak Z, Fazlollahi MR, Abel L, Bogunovic D, Shahrooei M, Cobat A, Carapito R, Molitor A, Vahidnezhad H, Béziat V, Bahram S, Jouanguy E, Casanova JL
Science immunology 2026 Feb 27;11(116):eadz8360
Science immunology 2026 Feb 27;11(116):eadz8360
Target-stabilized base editors enable robust high-fidelity RNA editing.
Liu T, Lin Y, Liu Q, Liao W, Lin Y, Zhang Y, Zhang J, Cao W, Yang L, Hong Z, Lu Z
Nature communications 2026 Feb 25;17(1)
Nature communications 2026 Feb 25;17(1)
Detection, isolation and molecular characterization of Senecavirus A in porcine semen: Implications for control programs.
Zhang X, Li X, Liu Y, Lv N, Yang B, Fu S, Jiang Z, Zhao P, Guo Y, Song J, Bian C, Yang D, Wang Z
Veterinary journal (London, England : 1997) 2026 Feb 25;:106616
Veterinary journal (London, England : 1997) 2026 Feb 25;:106616
Long Noncoding RNA H19 Mediates STAT3-Dependent Activation of Keratinocytes and Fibroblasts in Systemic Sclerosis Skin.
Caballero-Ruiz B, Wasson CW, Ross RL, Del Galdo F
Arthritis & rheumatology (Hoboken, N.J.) 2026 Feb 23;
Arthritis & rheumatology (Hoboken, N.J.) 2026 Feb 23;
De novo purine synthesis reprograms the macrophage inflammatory response and the immune response in sepsis.
Haskó G, Liu L, Németh ZH, Wagener G, Akcan U, Arif M, Pacher P, Kelestemur T
Research square 2026 Feb 19;
Research square 2026 Feb 19;
Toxoplasma gondii effector GRA35 mediates neuronal damage via ER stress and mitochondria-associated apoptosis.
Wang J, Chen Y, Zhou N, Li F, Dai N, Chen Z, Liu S, An R, Chen L, Du J
Virulence 2026 Dec;17(1):2654261
Virulence 2026 Dec;17(1):2654261
FDA-approved IMPDH inhibitors synergize with ribavirin to inhibit respiratory syncytial virus by interfering with purine de novo synthesis.
Hu H, Wang Q, Ai Q, Zhou P, He Y, Ye Z, Ma K, Zhou M, Huang S, Wang L, Qi N, Xiao G, Wang S
Emerging microbes & infections 2026 Dec;15(1):2640289
Emerging microbes & infections 2026 Dec;15(1):2640289
ARID1B regulates sphingolipid metabolism and myelin development via STAG2: Mechanistic insights into ARID1B-related coffin-siris syndrome.
Yang X, Gan Z, Zhou Y, Zhang M, Wu S, He F, Shen Z, Ma S, Su X, Xiong F
Cellular signalling 2026 Aug;144:112510
Cellular signalling 2026 Aug;144:112510
Cystinosin regulates Na(+)/H(+) exchanger 3 trafficking and function in kidney proximal tubular cells.
Khare V, Farré JC, Ait Kbaich M, Rocca CJ, Tang C, Ma X, Biederman K, Mathur I, Badell-Grau RA, Sivakumar A, Chen R, Catz SD, Cherqui S
EMBO reports 2026 Apr;27(8):2088-2117
EMBO reports 2026 Apr;27(8):2088-2117
Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury.
Quadri Z, Zhu Z, Ren X, Crivelli SM, Zhang L, Kunjadia PD, Sullivan PG, Broome BB, Yamasaki TR, Bieberich E
bioRxiv : the preprint server for biology 2026 Apr 3;
bioRxiv : the preprint server for biology 2026 Apr 3;
SEPHS2 loss reprograms cancer metabolism from oxidative phosphorylation to gluconeogenesis via PCK1 stabilization.
Zhang Y, Zhang Q, Wei B, Wang W, Chen X, Ding W, Li C, Ye Y, Xu J, Zhang W, Li L, Mai F, He W, Du X, Zhao K, Zhao Z, Huang J, Niu Y, Zhang Y, Dai L, Zhang B, Xia S
Cell reports 2026 Apr 25;45(5):117297
Cell reports 2026 Apr 25;45(5):117297
Preclinical evaluation of an mRNA vaccine developed from the first human isolate of bovine H5N1.
Li H, Huang M, Feng S, Li W, Wei D, Li X, Quan Y, Gu H, Jiang T, Liu Y, Lu J, Song W, Zhang X, Yang Y, Pan Q, Chen L, Yu J, Lou H, Zhang M, Wang Y, To KK, Jia W, Lin J, Zhang Q
Cell reports. Medicine 2026 Apr 21;7(4):102702
Cell reports. Medicine 2026 Apr 21;7(4):102702
Tumor-Derived Alpha-1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps-CCDC25 Pathway.
Fei Q, Li C, Zhan L, Li X, Hui Y, Jin Y, Zhang J, Yang L, Sun X, Li X, Dong Q, Zhang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 14;:e20000
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 14;:e20000
FAM117A and PIGU regulate the trilogy of gastric carcinogenesis.
Chen N, Wen Y, Liu Q, Du J, Yao D, Zhao M, Guo C, Wang T, Ma J, Tang J, Wang Y, Zeng J
Computational and structural biotechnology journal 2025;27:3952-3965
Computational and structural biotechnology journal 2025;27:3952-3965
IL-1β-Stimulated Bone Mesenchymal Stem Cell-Derived Exosomes Mitigate Sepsis through Modulation of HMGB1/AKT Pathway and M2 Macrophage Polarization.
Li Y, Sun Z, Li Y, Sun J, Chen B
Current molecular medicine 2025;25(1):79-89
Current molecular medicine 2025;25(1):79-89
MUC15 acts as a tumor suppressor gene which correlates with prognosis and immune infiltration in esophageal squamous cell carcinoma.
Fei X, Wang AL, Wu H, Xing SW, Chen L, Chen Y, Lin XJ, Liu HL, Sun B
International journal of medical sciences 2025;22(8):1905-1915
International journal of medical sciences 2025;22(8):1905-1915
Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development.
Wei T, Lin R, Lu Y, Jin DY, Zhang J, Sham MH
International journal of biological sciences 2025;21(3):1081-1096
International journal of biological sciences 2025;21(3):1081-1096
Fibroblast Growth Factor 20 Attenuates Colitis by Restoring Impaired Intestinal Epithelial Barrier Integrity and Modulating Macrophage Polarization via S100A9 in an NF-κB-Dependent Manner.
Zhen D, Wang S, Liu Z, Xi Y, Du H, Wang N, Gao X, Lin Z, Wu F
Cellular and molecular gastroenterology and hepatology 2025;19(6):101486
Cellular and molecular gastroenterology and hepatology 2025;19(6):101486
Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice.
Yin H, Hu J, Li Y, Feng Y, Li Z, Sun R, Tian L, Li Y
Journal of inflammation research 2025;18:7323-7336
Journal of inflammation research 2025;18:7323-7336
Early-life hearing loss induces persistent cognitive deficits: evidence from human data and a mouse model with environmental intervention.
Zhou X, Yu H, Wang Y, Chen K, Shen X
Frontiers in aging neuroscience 2025;17:1662732
Frontiers in aging neuroscience 2025;17:1662732
DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation.
Zhang M, Xie X, Da G, Li H, Jin Y
Frontiers in immunology 2025;16:1656069
Frontiers in immunology 2025;16:1656069
Novel USP18 mutations lead to severe interferonopathy responsive to JAK inhibitor.
Sun X, Li M, Dou Y, Wang Q, Lai J, Zhu J, Zhou Q, Yu X
Frontiers in immunology 2025;16:1646996
Frontiers in immunology 2025;16:1646996
SENP3/FIS1-regulated PFC neural mitochondrial fragmentation underlies the mechanism of electroacupuncture attenuating depressive behavior in CUMS mice.
Lai S, Qiu X, Lin P, Wu J, Li F, Lai N, Li X, Tu T, Zhang J, Huang Y, Zhang Z
Frontiers in psychiatry 2025;16:1645757
Frontiers in psychiatry 2025;16:1645757
Comprehensive analysis based on the ubiquitination- and deubiquitylation-related genes reveals the function of NEURL3 in esophageal squamous cell carcinoma.
Lin YW, Li HE, Hong CQ, Chen ZA, Liu SP, Xu YW, Wu FC, Peng YH
Frontiers in immunology 2025;16:1632090
Frontiers in immunology 2025;16:1632090
Yiai Fuzheng decoction inhibits triple-negative breast cancer by remodeling the immune microenvironment.
Yu C, Jia C, Chen G, Li Y, Liu Y, Zhang Y
Frontiers in immunology 2025;16:1615631
Frontiers in immunology 2025;16:1615631
Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis.
Lan Y, Dong C, Wu M, Yuan R, Yang K, Yang Z, Chen Y, Zhang J, Qi B, Lu X
Frontiers in pharmacology 2025;16:1594757
Frontiers in pharmacology 2025;16:1594757
Shengxian decoction alleviates cyclophosphamide-induced immunosuppression via improving B cell-mediated immune responses.
Yang C, Xu Y, Gong F, Li S, Zhan H, Huang Z, Wang M, Li H, Huang H
Frontiers in pharmacology 2025;16:1565451
Frontiers in pharmacology 2025;16:1565451
BTG2-deficient mast cells remodel the tumor and tumor-draining lymph node microenvironment leading to chemotherapy resistance in breast cancer.
Zhang X, Wang J, Liu Z, Wen J, Kang M, Fang C, Ren L
Frontiers in immunology 2025;16:1562700
Frontiers in immunology 2025;16:1562700
Polymethoxyflavones extracted from Bauhinia championii alleviate LPS-induced acute lung injury by ameliorating endoplasmic reticulum stress.
Li Y, Yang X, Ye W, Jing J, Chen R, Wu L, You Z, Zhang S, Shi J
Frontiers in pharmacology 2025;16:1544916
Frontiers in pharmacology 2025;16:1544916
Identification of DAP3 as candidate prognosis marker and potential therapeutic target for hepatocellular carcinoma.
Yuan LX, Yue ZQ, Ma QR, Zhang P, Xiao F, Chen L
Frontiers in immunology 2025;16:1528853
Frontiers in immunology 2025;16:1528853
Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers.
Phung CD, Tran TTT, Yeo BZJ, Prajogo RC, Saudjana E, Yeo EYM, Gao C, Nguyen PHD, Jayasinghe MK, Dang XTT, Lixuan CP, Nguyen TM, Peng B, Le AH, Nguyen TTT, Chan GME, Loh YH, Goh BC, Tam WL, Bonney GK, Luo D, Le MTN
Theranostics 2025;15(14):6818-6838
Theranostics 2025;15(14):6818-6838
Optimization of donor structure enhances the generation of cloned goats with high expression of human butyrylcholinesterase by CRISPR/Cas9.
Wu Y, Zheng J, Chen J, Sun T, Luan T, Li Y, Fa Y, Qiu Y, Zhang R
Frontiers in bioengineering and biotechnology 2025;13:1633553
Frontiers in bioengineering and biotechnology 2025;13:1633553
Inactivation of Acetyl-CoA Acyltransferase 1 enhances the proliferation and motility of nasopharyngeal carcinoma cells.
Wei W, Li L, Zhao W, Zheng S, Zhou X, Liang H, Wang W, He F, Liang Y, Huang G, Zhang Z, Xiao X
Molecular & cellular oncology 2025;12(1):2583342
Molecular & cellular oncology 2025;12(1):2583342
Androgen receptor activation promotes tumor progression in canine and human triple negative breast cancer cell lines.
Caceres S, Crespo B, Herrera M, de la Puente M, Diaz Del Arco C, Alonso-Diez A, Illera MJ, Illera JC
Frontiers in veterinary science 2025;12:1677830
Frontiers in veterinary science 2025;12:1677830
Constructing a novel mitochondrial metabolism-related genes signature to evaluate tumor immune microenvironment and predict survival of colorectal cancer.
Wang H, Zhang K, Ning G
Frontiers in medicine 2025;12:1618471
Frontiers in medicine 2025;12:1618471
Neutrophil-related IL1R2 gene predicts the occurrence and early progression of myocardial infarction.
Tang J, Tudi X, Zhang T, Zhu J, Shen T
Frontiers in cardiovascular medicine 2025;12:1516043
Frontiers in cardiovascular medicine 2025;12:1516043
Deciphering phenylalanine-derived salicylic acid biosynthesis in plants.
Wang Y, Song S, Zhang W, Deng Q, Feng Y, Tao M, Kang M, Zhang Q, Yang L, Wang X, Zhu C, Wang X, Zhu W, Zhu Y, Cao P, Chen J, Pan J, Feng S, Chen X, Dai H, Song S, Yang J, Zhao T, Cao F, Tao Z, Shen X, Last RL, Hu J, Yu J, Fan P, Pan R
Nature 2025 Sep;645(8079):208-217
Nature 2025 Sep;645(8079):208-217
The spike 486 site is a key immune evasion point and a determinant of the immunogenicity of the RBD-dimer mRNA vaccine against SARS-CoV-2 variants.
Feng S, Huang M, Quan Y, Sun L, Lin J, Zhang D, Wei X, Wang Z, Ma X, Wang S, Pan Q, Jia W, Wei D, Feng G, Xu M, Deng Z, Zhang Q
Virology 2025 Sep;610:110612
Virology 2025 Sep;610:110612
sVEGFR1 up-regulation via EGR1 impairs vascular repair in SFTSV-induced hemorrhage.
Jiang N, Wu J, He Y, Zhang R, Ji M, Zhu L, Cui S, You Q, Cai Y, Liu B, Lyu R, Chen Y, Zhu J, Wu Z
EMBO reports 2025 Sep;26(18):4477-4502
EMBO reports 2025 Sep;26(18):4477-4502
m6A reader YTHDF3 elicits hypertensive effects by degrading XRCC1 mRNA in the rostral ventrolateral medulla.
Zhang S, Wang X, Zhao B, Dai T, Wang L, Tong L, Zeng Q, He Q, Zhang H, Du D
Free radical biology & medicine 2025 Sep;237:300-311
Free radical biology & medicine 2025 Sep;237:300-311
Leishmania donovani infection-driven high levels of IL-10 causes hypoalbuminemia in human visceral leishmaniasis.
Singh B, Saini S, Kumari S, Shah A, Singh K, Chaturvedi CP, Dube A, Sahatrabuddhe AA, Thakur CP, Rai AK
Cytokine 2025 Sep;193:156981
Cytokine 2025 Sep;193:156981
Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism.
Tang R, Zhang Z, Liu X, Liao Y, Chen Y, Xiao M, Li Y, Zhou C, Tan Z, Zhang C, Chen C, Rong Z, Liu Y, Li P, Du Q, He Q, Lei Y, Wu Z, Lu S, Xu J, Wang W, Shi S, Yu X
Gastroenterology 2025 Sep;169(4):615-631.e32
Gastroenterology 2025 Sep;169(4):615-631.e32
CRISPR/Cas9-Mediated TARDBP Knockout Reduces Triacylglycerol Content and Key Milk Fat Metabolism Gene Expression in MAC-T Cells.
Zhang Y, Zhang Q, Gao Y, Xiao Y, Wang J, Yang C, Ju Z, Wei X, Wang X, Jiang Q, Huang J
Animals : an open access journal from MDPI 2025 Sep 5;15(17)
Animals : an open access journal from MDPI 2025 Sep 5;15(17)
Ultrasound-activated directional and controllable nitric oxide therapy for vascular calcification repair through the modulation of eNOS/iNOS homeostasis.
Liu C, Lin M, Dai J, Chen B, Wang J, Li J, Li X, Jiang Z, Xiao M, Tang M
Acta biomaterialia 2025 Sep 17;
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METTL3 suppresses inflammatory responses by regulating SIRT1-mediated HMGB1 release in sepsis.
Zhang L, Zuo F, Li J, Zeng Z, Chen Y, Lan Y, Chen Y, Gong Y, Chen J, Luo G, Song H, Peng Y, Yuan Z
European journal of pharmacology 2025 Sep 15;1003:177959
European journal of pharmacology 2025 Sep 15;1003:177959
Hemopexin Suppresses Hepatocellular Carcinoma via TNF-α-Mediated Mitochondrial Apoptosis.
Ren L, Man Y, Zhang X, Guo Q, She S, Yang Y, Fei R, Cong X, Chen D, Wei W, Chen H
Cancers 2025 Sep 11;17(18)
Cancers 2025 Sep 11;17(18)
CKD-Induced Oxidative Twitch Muscle Atrophy Is Mediated by TGF- β.
Homma K, Enoki Y, Taguchi K, Matsumoto K
Kidney360 2025 Sep 1;6(9):1438-1447
Kidney360 2025 Sep 1;6(9):1438-1447
CUMS stress facilitates hippocampal neural mitophagy through FIS1/MFF-mediated mitochondrial fragmentation.
Qiu X, Lai S, Zhang Y, Huang S, Zhang J, Tan Y, Li H, Liu J, Huang Y, Zhang Z
Journal of neurophysiology 2025 Sep 1;134(3):952-961
Journal of neurophysiology 2025 Sep 1;134(3):952-961
Reprogramming neuroblastoma by diet-enhanced polyamine depletion.
Cherkaoui S, Turn CS, Yuan Y, Lu W, Yang L, McBride MJ, Eigenmann C, Allen GE, Panasenko OO, Zhang L, Vu A, Liu K, Li Y, Gandhi OH, Surrey LF, Kienast SD, Leidel SA, Wierer M, White E, Rabinowitz JD, Hogarty MD, Morscher RJ
Nature 2025 Oct;646(8085):707-715
Nature 2025 Oct;646(8085):707-715
Conserved domains of flagellin as adjuvants for an inactivated vaccine against porcine epidemic diarrhea virus.
Afzal H, Hoa NT, Murtaza A, Doan TD, Chung YC, Ke GM, Cheng LT
Veterinary journal (London, England : 1997) 2025 Oct;313:106393
Veterinary journal (London, England : 1997) 2025 Oct;313:106393
Synthesis and anticancer studies of Ru/Ir arene complexes bearing oleanolic acid in acute promyelocytic leukemia cells.
Dai XY, Shen ZQ, Zhang Y, Liu H, Ren M, Wang P, Li J, Xue X, Liu HK
Journal of inorganic biochemistry 2025 Oct;271:112959
Journal of inorganic biochemistry 2025 Oct;271:112959
Hinokitiol modulates Nrf2/HO-1 signaling, autophagy, and URAT1 in hyperuricemia and oxidative stress models of renal injury.
Chiang YF, Huang KC, Huang YJ, Wang KL, Huang YJ, Shieh TM, Ali M, Hsia SM
Free radical biology & medicine 2025 Oct;238:169-178
Free radical biology & medicine 2025 Oct;238:169-178
Activation of GABA transmission by clonazepam reverses the autistic-like phenotypes of the Cav3.2 knockout mice.
Liang SF, Ming Y, Huang HT, Lo RY, Chompoopong S, Chen CC, Liu IY
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 Oct;22(6):e00761
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 Oct;22(6):e00761
Wogonin modulates macrophage polarization and inflammatory signaling through the LSD1-p65 axis to alleviate osteoarthritis.
Cai Z, Lu C, Chen D, Zhang S, Zhou J, Yu S, Wong CK, Jia Z, Jin S, Feng Y, Wu P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157149
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157149
Upregulation of LINC02154 promotes esophageal cancer progression by enhancing cell cycling and epithelial-mesenchymal transition.
Shimote K, Niinuma T, Kitajima H, Ishiguro K, Yamamoto E, Sudo G, Yorozu A, Toyota M, Kai M, Idogawa M, Suzuki H
Non-coding RNA research 2025 Oct;14:107-116
Non-coding RNA research 2025 Oct;14:107-116
Targeting RelA/NLRP3/CCL3 axis mitigates microglia inflammatory response and promotes recovery after spinal cord injury.
Song W, Fu R, Yuan Z, Liu Y, Kao Y, Zhang R, Gu G, Zhu H, Liu H, Zhang Z, Kong X, Feng S
Brain, behavior, and immunity 2025 Oct;129:801-817
Brain, behavior, and immunity 2025 Oct;129:801-817
A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution.
Zhang Z, Wu Y, Hou K, Zhang Y, Chen L, Yang M, Jin Z, Xu Y, Zhang Y, Cai Y, Zhao J, Sun S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e02013
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e02013
Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity.
Jiang T, Jing S, Li H, Xiao B, Jin J, Sun X, Wang J, Liang J, Cai T, Hu H, Wei M, Zhong X, Ji Y, Wang PG, Zhou J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e17205
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e17205
ER-phagy Activation by AMFR Attenuates Cardiac Fibrosis Post-Myocardial Infarction via mTORC1 Pathway.
Wang Z, Niu K, Liu W, Wang X, Yang B, Li T, Chen Y, Jin Y, Chen Y, Lin Y, Jin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e04552
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e04552
ILF3 downregulation by circMETTL9: Effect on traumatic brain injury-induced neuroinflammation.
Sun L, Huang H, Hu Y, Guan Y, Zhu J, Xiao C, Zhang ZJ, Liu S
Experimental neurology 2025 Oct 6;395:115490
Experimental neurology 2025 Oct 6;395:115490
The CBS/H2S axis regulates intestinal stem cell homeostasis and radiation-induced intestinal damage.
Wu T, Zheng Z, Ren J, Yang Z, Zhang N, Guo K, Chen D, Gao M, Chen Y, Liang X, Wang Y, Chen W, Su Y, He J, Wang F
Stem cell research & therapy 2025 Oct 31;16(1):603
Stem cell research & therapy 2025 Oct 31;16(1):603
Tumor-derived RAC1(A159V) mutation promotes an immunosuppressive microenvironment that represses response to immune checkpoint inhibitor.
Cai M, Adam M, Duan X, Guo F, Zheng Y
Science advances 2025 Oct 31;11(44):eaea1212
Science advances 2025 Oct 31;11(44):eaea1212
CD169(+) macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis.
Hu J, Guo F, Han C, Zhao Q, Yi H, Xu J, Jia H, Wu Y, Dong L, Kao X, Li G, Chen J, Zhang J, Huang Z
Cell reports 2025 Oct 28;44(10):116351
Cell reports 2025 Oct 28;44(10):116351
Stage-specific roles of clonally expanded CD8(+) T cells in regulating amyloid pathology in Alzheimer's disease models.
Ohyagi M, Ito M, Iizuka-Koga M, Mise-Omata S, Yoshimura A
Nature communications 2025 Oct 27;16(1):9458
Nature communications 2025 Oct 27;16(1):9458
Developing an eVLP mRNA vaccine for respiratory syncytial virus with enhanced pre-fusion targeting humoral responses.
Sun L, Huang M, Feng S, Zhang W, Quan Y, Chen R, Yang Y, Xu H, Li W, Pan Q, Chen X, Zhang D, Yuan B, Zhao J, Wang Z, Lin J, Peng W, Ludlow M, Zhang Q
Journal of virology 2025 Oct 23;99(10):e0120925
Journal of virology 2025 Oct 23;99(10):e0120925
Breaking the link between morphology and potency for mESCs.
Fan Y, Wang X, Zhai Z, Huang T, Li W, Liang Z, Ma Z, Fu Y, Li P, Kuang J, Pei D
Cell & bioscience 2025 Oct 23;15(1):146
Cell & bioscience 2025 Oct 23;15(1):146
CircCdh7 induces astrogliosis and neuroinflammation to trigger hypertensive effects in the rostral ventrolateral medulla.
Zhang S, Dai T, Zhao B, Wang X, Wang L, Tong L, Zeng Q, He Q, Zhang H, Du D
Cell & bioscience 2025 Oct 19;15(1):141
Cell & bioscience 2025 Oct 19;15(1):141
Estrogen Receptor Regulates Male Satellite Cells in a Female, but Not Male, Environment.
Shams AS, Sullivan BP, Toso EA, Lowe DA, Kyba M
Cells 2025 Oct 16;14(20)
Cells 2025 Oct 16;14(20)
Identification of an IL17RC missense variant in a Chinese family with multiple osteochondromas and ankylosing spondylitis.
Zheng Y, Wei X, Gan Z, Zhang M, Shen Z, Ma S, Huang Y, He F, Wang J, Xiong F
Journal of human genetics 2025 Nov;70(11):557-564
Journal of human genetics 2025 Nov;70(11):557-564
Molecular mechanisms of synovial pathology in osteoarthritis: insights from CXCL10 and MC4R expression.
Yang T, Liu H, Chen J
Genes & genomics 2025 Nov;47(11):1147-1162
Genes & genomics 2025 Nov;47(11):1147-1162
Chemotherapy-induced CA-repeat DNA fragments in breast cancer trigger antitumor immune responses.
Zhang X, Huang P, Chen H, Yang C, Yang X, Liu Y, Wu B, Zeng W, Saw PE, Ye S, Li J, Wang J, Wu Z, Wang J, Li H, Huang JD, Zeng M, Li M, Liu Q, Su S, Song E, Chen J
Nature immunology 2025 Nov;26(11):1931-1945
Nature immunology 2025 Nov;26(11):1931-1945
Proteogenomic Reassessment Provides Novel Insight into the Life Cycle of Tetrahymenathermophila.
Gu C, Yang M, Zhang J, Wang G, Fu L, Chen K, Li L, Zhang P, Luo S, Yang F, Zhan J, Miao W, Ge F, Xiong J
Molecular & cellular proteomics : MCP 2025 Nov;24(11):101081
Molecular & cellular proteomics : MCP 2025 Nov;24(11):101081
Piezo1-Mediated Calcium Flux Transfers Mechanosignal to Yes-Associated Protein to Stimulate Matrix Production in Keloid.
Liao C, Wang P, Zeng Q, Yan G, Gao J, Liu J, Yan J, Zhang G, Liu Y, Wang X
The Journal of investigative dermatology 2025 Nov;145(11):2869-2881.e9
The Journal of investigative dermatology 2025 Nov;145(11):2869-2881.e9
Spatial Transcriptional Dynamics of CD74⁺ B Cells in Tertiary Lymphoid Structures Drive Immune Evolution in Penile Squamous Cell Carcinoma.
Xue T, Deng C, Liu J, Yan R, Li J, Hu X, Li X, Xiao X, Jin J, Tang H, Chen D, Zuo Z, Liang Y, Wang D, Chen B, Han H, Li Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e09742
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e09742
XBP1s Mediates Cross-resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer.
Sang Y, Liu S, Zhou X, Chi W, Xiong M, Chen M, Ren H, Liu D, Zhang L, Xue J, Chi Y, Wu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e09588
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e09588
A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity against Flaviviridae viruses by preventing endosomal acidification.
Chen G, Li W, Lam KH, Hu M, Wu Q, Xu X, Huang Y, Tang F, Cui G, Cui P, Zuo J, Liu L, Qian J, Zhang H-J, Li Y-P
Antimicrobial agents and chemotherapy 2025 Nov 5;69(11):e0052725
Antimicrobial agents and chemotherapy 2025 Nov 5;69(11):e0052725
Tau Hypophosphorylation at Ser416 as the Early Molecular Imprint of Maternal Immune Activation: Insights from Female Mice Offspring.
Bielska E, Matuszewska M, Wójcik P, Wilkaniec A, Cieślik M, Gąssowska-Dobrowolska M, Sulejczak D, Czapski GA, Adamczyk A
International journal of molecular sciences 2025 Nov 5;26(21)
International journal of molecular sciences 2025 Nov 5;26(21)
KDM3A drives NSCLC proliferation and metastasis via H3K9 demethylation, EMT activation and MMP-9 upregulation.
Shi B, Wang Z, Xiu L, Li L, Yang X, Wang G, Li J, Wang H, Han Y
Biomolecules & biomedicine 2025 Nov 3;26(5):830-843
Biomolecules & biomedicine 2025 Nov 3;26(5):830-843
Impact of C-Terminal PKC Phosphorylation on TRPC6 Current Kinetics.
Keck M, Pöll S, Schmelzer H, Kressmann T, Hermann C, Mederos Y Schnitzler M, Storch U
International journal of molecular sciences 2025 Nov 27;26(23)
International journal of molecular sciences 2025 Nov 27;26(23)
Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis.
Fan K, Zhou S, Ren Y, Xiong J, Wang H, Fu Y, Chen Y, Wang B, Fan K, Gao M, Guo T, Wei X, Jiao L, Shi J, Ding C, Zhang Y
Cell death and differentiation 2025 Nov 27;
Cell death and differentiation 2025 Nov 27;
METTL3 and METTL14 determine human neural fate specifications.
Zhang Y, Zhang J, Lin H, Wang J, Chen Q, Zhou T, Xing Q, Pan G, Shan Y
Nucleic acids research 2025 Nov 26;53(22)
Nucleic acids research 2025 Nov 26;53(22)
Modeling CIC::DUX4 sarcoma reveals oncogene-mediated MHCI-dependent immune evasion.
Vachanaram AR, Wei E, Mitanoska A, Bassett W, Kyba M, Bosnakovski D
Molecular cancer 2025 Nov 26;24(1):299
Molecular cancer 2025 Nov 26;24(1):299
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Zhang C, Wang H, He Z, He J, Wang F, Yan S, Sheng Y, Yuan N, Chen Y, Xu X, Huang Y, Hu R, Wang M, Xiao W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
10-hydroxydec-2-enoic acid alleviates post-myocardial infarction inflammation and oxidative stress by modulating the TLR4 signaling axis.
Zhao R, Xie Y, Xu K, Liu Y, Chen R, Zhao S, Zhou Z, Xie Z, Jiang Y, Lin F, Zhu J, Chen G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157457
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157457
Design and Synthesis of Novel Candidate CK1δ Proteolysis Targeting Chimeras (PROTACs).
Arnold M, Thompson T, Glennie L, Hollnagel M, Sapkota G, Peifer C
Molecules (Basel, Switzerland) 2025 Nov 18;30(22)
Molecules (Basel, Switzerland) 2025 Nov 18;30(22)
Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier.
Sorets AG, Schwensen KR, Francini N, Kjar A, Lyons S, Park JC, Palmer D, Abdulrahman AM, Cowell RP, Katdare KA, Hoogenboezem EN, Wang A, Ligocki AP, Embalabala RJ, Dani N, Duvall CL, Lippmann ES
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114226
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114226
Unveiling prognostic biomarkers and immunotherapeutic insights in prostate cancer through multi-omics and machine learning.
Tang H, Zhang W, Tao J, Zhang Y, Xing F, Wang Y, Yan Z, Gao Y, Zhang Z
European journal of medical research 2025 Nov 10;30(1):1093
European journal of medical research 2025 Nov 10;30(1):1093
Nuclear SREBP2 condensates regulate the transcriptional activation of lipogenic genes and cholesterol homeostasis.
Xu M, Jiang SY, Tang S, Zhu M, Hu Y, Li J, Yan J, Qin C, Tan D, An Y, Qu Y, Song BL, Ma H, Qi W
Nature metabolism 2025 May;7(5):1034-1051
Nature metabolism 2025 May;7(5):1034-1051
Semaglutide administration protects cardiomyocytes in db/db mice via energetic improvement and mitochondrial quality control.
Tian MY, Yang JQ, Hu JC, Lu S, Ji Y
Acta pharmacologica Sinica 2025 May;46(5):1250-1261
Acta pharmacologica Sinica 2025 May;46(5):1250-1261
The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
Chen J, Xu W, Meng L, Zhang X, Lin M, Zhang S, Liu Y, Guo F
Journal of cellular and molecular medicine 2025 May;29(10):e70616
Journal of cellular and molecular medicine 2025 May;29(10):e70616
Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease.
Hu M, Xu Q, Zhang F, Buckland KF, Gao Y, Du W, Ding Y, Zhou L, Sun X, Ma L, Zhang Z, Tang X, Zhao X, Thrasher AJ, An Y
Genes & diseases 2025 May;12(3):101445
Genes & diseases 2025 May;12(3):101445
Differential Effects of Rutin and Its Aglycone Quercetin on Cytotoxicity and Chemosensitization of HCT 116 Colon Cancer Cells to Anticancer Drugs 5-Fluorouracil and Doxorubicin.
Suman I, Jezidžić A, Dobrić D, Domitrović R
Biology 2025 May 9;14(5)
Biology 2025 May 9;14(5)
Innovative evaluation of selinexor and JQ1 synergy in leukemia therapy via C-MYC inhibition.
Wang PH, Hu CH, Fan JQ, He JJ, Deng TF, Xu YL, Dai YJ, Wang SQ
Journal of translational medicine 2025 May 8;23(1):520
Journal of translational medicine 2025 May 8;23(1):520
Hedgehog inhibitors exert anti-proliferation effects and synergistically interact with trastuzumab in HER2-positive gastric cancer models.
Yang Z, Niu R, Han J, Guo J, Lv Y
Acta oncologica (Stockholm, Sweden) 2025 May 27;64:715-728
Acta oncologica (Stockholm, Sweden) 2025 May 27;64:715-728
Linker-free PROTACs efficiently induce the degradation of oncoproteins.
Zhang J, Chen C, Chen X, Liao K, Li F, Song X, Liu C, Su MY, Sun H, Hou T, Tan CSH, Fang L, Rao H
Nature communications 2025 May 23;16(1):4794
Nature communications 2025 May 23;16(1):4794
Development of p300-targeting degraders with enhanced selectivity and onset of degradation.
Marsh GP, Cooper MS, Goggins S, Reynolds SJ, Wheeler DF, Cresser-Brown JO, Arnold RE, Babcock EG, Hughes G, Bosnakovski D, Kyba M, Ojeda S, Harrison DA, Ott CJ, Maple HJ
RSC medicinal chemistry 2025 May 22;16(5):2049-2060
RSC medicinal chemistry 2025 May 22;16(5):2049-2060
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Lin K, Wei W, Chen S, Gong Y, Wang X, Wang M, Li R, Zhao Y, Xu S, Jin C, Jiang C, Fu G, Li Q
Cell death & disease 2025 May 22;16(1):409
Cell death & disease 2025 May 22;16(1):409
Systems Genetics Reveals the Gene Regulatory Mechanisms of Arrb2 in the Development of Autism Spectrum Disorders.
Xia J, Bajpai AK, Liu Y, Yu L, Dong Y, Li F, Chen F, Lu L, Feng S
Genes 2025 May 20;16(5)
Genes 2025 May 20;16(5)
Anlotinib enhances the efficacy of KRAS-G12C inhibitors through c-Myc/ORC2 axis inhibition in non-small cell lung cancer.
Liu H, Zhou C, Lu J, Liu Y, Zou P, Zhu L, Lei H, Han B
Cell death & disease 2025 May 2;16(1):356
Cell death & disease 2025 May 2;16(1):356
Exposure to Sucralose and Its Effects on Testicular Damage and Male Infertility: Insights into Oxidative Stress and Autophagy.
Chiang YF, Chen YC, Huang KC, Ali M, Hsia SM
Environmental health perspectives 2025 May 16;
Environmental health perspectives 2025 May 16;
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism.
Zhang Z, Zheng L, Chen Y, Chen Y, Hou J, Xiao C, Zhu X, Zhao SM, Xiong JW
eLife 2025 May 15;13
eLife 2025 May 15;13
Hyperglycaemia-induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals.
Lu S, Baier MJ, Polonen RP, Liao Z, Martin JL, Ginsburg KS, Mustroph J, Bers DM
The Journal of physiology 2025 May 11;
The Journal of physiology 2025 May 11;
Mitochondrial NAD(+) deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm.
Zhang J, Tang Y, Zhang S, Xie Z, Ma W, Liu S, Fang Y, Zheng S, Huang C, Yan G, Abudupataer M, Xin Y, Zhu J, Han W, Wang W, Shen F, Lai H, Liu Y, Ye D, Yu FX, Xu Y, Pan C, Wang C, Zhu K, Zhang W
Nature cardiovascular research 2025 Mar;4(3):275-292
Nature cardiovascular research 2025 Mar;4(3):275-292
Application of integrated omics in aseptic loosening of prostheses after hip replacement.
Liu YK, Dong YH, Liang XM, Qiang S, Li ME, Sun Z, Zhao X, Yan ZH, Zheng J
Molecular medicine reports 2025 Mar;31(3)
Molecular medicine reports 2025 Mar;31(3)
Hypoxia-induced increase in sphingomyelin synthase 2 aggravates ischemic skeletal muscle inflammation.
Mizugaki H, Nagane M, Sato-Akaba H, Kmiec M, Kuppusamy P, Yasui H, Inanami O, Murakami H, Aihara N, Kamiie J, Mizunoya W, Yasuda I, Fukuyama T, Naya Y, Yamashita T
The FEBS journal 2025 Mar;292(5):1086-1105
The FEBS journal 2025 Mar;292(5):1086-1105
Transgenic mice expressing the human CDHR3 receptor: A sensitive RV-C infection model for the evaluation of vaccines and therapeutics.
Zhou Z, Zhu R, Yang H, Deng W, Zhang Z, Li Y, Xu J, Yan Z, Wang R, Chang S, Yin Z, Wu Y, Zhang D, Fang M, Liu C, Que Y, Zhang J, Xia N, Wang Y, Xu L, Cheng T
Antiviral research 2025 Mar;235:106102
Antiviral research 2025 Mar;235:106102
Improved Black Phosphorus Nanocomposite Hydrogel for Bone Defect Repairing: Mechanisms for Advancing Osteogenesis.
Wu A, Ma G, Chen Y, Gui H, Sun B, Zhang B, Liu Y, Zhang S, Lian G, Song D, Zhang D
Advanced healthcare materials 2025 Mar;14(7):e2404934
Advanced healthcare materials 2025 Mar;14(7):e2404934
Microglia-Derived Interleukin-6 Triggers Astrocyte Apoptosis in the Hippocampus and Mediates Depression-Like Behavior.
Shen SY, Liang LF, Shi TL, Shen ZQ, Yin SY, Zhang JR, Li W, Mi WL, Wang YQ, Zhang YQ, Yu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2412556
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2412556
Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes.
Jiang Y, He K, Shen Q, Yang C, Huang X, Fan J, Du M, Wu J, Ruan H, Yang J, Hong Y
International journal of toxicology 2025 Mar-Apr;44(2):141-152
International journal of toxicology 2025 Mar-Apr;44(2):141-152
FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology.
Yu L, Yang YX, Gong Z, Wan Q, Du Y, Zhou Q, Xiao Y, Zahr T, Wang Z, Yu Z, Yang K, Geng J, Fried SK, Li J, Haeusler RA, Leong KW, Bai L, Wu Y, Sun L, Wang P, Zhu BT, Wang L, Qiang L
Cell metabolism 2025 Mar 4;37(3):656-672.e7
Cell metabolism 2025 Mar 4;37(3):656-672.e7
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Fang X, Zhong Y, Zheng R, Wu Q, Liu Y, Zhang D, Wang Y, Ding W, Wang K, Zhong F, Lin K, Yao X, Hu Q, Li X, Xu G, Liu N, Nie J, Li D, Geng H, Guan Y
Science advances 2025 Mar 21;11(12):eadr8648
Science advances 2025 Mar 21;11(12):eadr8648
Structural basis for the substrate recognition and transport mechanism of the human y(+)LAT1-4F2hc transporter complex.
Dai L, Zeng Q, Zhang T, Zhang Y, Shi Y, Li Y, Xu K, Huang J, Wang Z, Zhou Q, Yan R
Science advances 2025 Mar 21;11(12):eadq0558
Science advances 2025 Mar 21;11(12):eadq0558
ZIP14 Deletion Disrupts Divalent Metal Homeostasis in Mouse Cerebrospinal Fluid.
McCabe SM, Zhao N
Cell biochemistry and function 2025 Jun;43(6):e70086
Cell biochemistry and function 2025 Jun;43(6):e70086
Effects of Adalimumab on Mitochondria of Psoriatic Mesenchymal Stem Cells.
Di Vincenzo M, Campanati A, Cannelonga G, Diotallevi F, Cerqueni G, Marani A, Marchi S, Orciani M
Journal of cellular and molecular medicine 2025 Jun;29(11):e70642
Journal of cellular and molecular medicine 2025 Jun;29(11):e70642
The NET-DNA-CCDC25 inhibitor di-Pal-MTO suppresses tumor progression and promotes the innate immune response.
Wang S, Liang X, Li H, Zou J, Xu L, Zhang Y, Lin J, Zeng J, Zhong X, Liu X, Liu Z, Zheng Y, Nie M, Yang L
Cellular & molecular immunology 2025 Jun;22(6):628-644
Cellular & molecular immunology 2025 Jun;22(6):628-644
Time-restricted feeding mitigates HFD-induced sarcopenic obesity in aging mice through improving the sensitivity of FGF21.
Wang T, Lin H, Deng Y, Chen W, Xu Y, Wang L, Zhou A, Zhang Y, Wang Z, Jin X, Zhang L, Wang X, Zhou Y, Wang R, Rong S
The Journal of nutritional biochemistry 2025 Jun;140:109893
The Journal of nutritional biochemistry 2025 Jun;140:109893
Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer.
Hua Y, Duan N, Sun C, Yang F, Tian M, Sun Y, Zhao S, Gong J, Liu Q, Huang X, Liang Y, Fu Z, Li W, Yin Y
eLife 2025 Jun 4;14
eLife 2025 Jun 4;14
Beyond Stress Granules: G3BP1 and G3BP2 Redundantly Suppress SARS-CoV-2 Infection.
Xu D, Biswal M, Zhang Q, Light C, Wu Y, Ye C, Martínez-Sobrido L, Song J, Hai R
Viruses 2025 Jun 27;17(7)
Viruses 2025 Jun 27;17(7)
Endoplasmic reticulum-anchored nonstructural proteins drive human astrovirus replication organelle formation.
Bengert B, Mehri S, Holliday M, Lennemann NJ
bioRxiv : the preprint server for biology 2025 Jun 25;
bioRxiv : the preprint server for biology 2025 Jun 25;
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRAS(G12D)-mutant cancer.
Chen Y, Yan Q, Ruan S, Cui J, Li Z, Zhang Z, Yang J, Fang J, Liu S, Huang S, Hou B, Zhang C
Cell reports 2025 Jun 24;44(6):115774
Cell reports 2025 Jun 24;44(6):115774
Mycobacterium tuberculosis PPE18 Protein Bodies in Insect Cells: A Candidate Tuberculosis Vaccine.
Wang P, Zhang G, Cai Y, Jiang L, Niu X, Zhang S, Gao W, Wu Z, Li Y
Vaccines 2025 Jun 23;13(7)
Vaccines 2025 Jun 23;13(7)
Ginsenoside Rh2 Exerts a Therapeutic Effect against Myocardial Infarction via Promoting Angiogenesis and Mitochondrial Bioenergetics.
Duan Z, Yuan B, Li H, Yang J, Xiao X, Wei K
Journal of agricultural and food chemistry 2025 Jun 18;73(24):15056-15066
Journal of agricultural and food chemistry 2025 Jun 18;73(24):15056-15066
The contribution of native protein complexes to targeted protein degradation.
Glennie L, Curnutt N, Cartwright T, Dunbar K, Le Chatelier B, Wood NT, Macartney TJ, Woo CM, Sapkota GP
bioRxiv : the preprint server for biology 2025 Jun 17;
bioRxiv : the preprint server for biology 2025 Jun 17;
Formoterol, the Most Effective Bronchodilator, Has No Anti-Inflammatory nor Metabolic Modulatory Effects in Severe Asthma Induced by Aspergillus fumigatus.
Gan PXL, Linke KM, Liao W, Wong WSF
ACS pharmacology & translational science 2025 Jun 13;8(6):1556-1566
ACS pharmacology & translational science 2025 Jun 13;8(6):1556-1566
Structural Optimization of Next-Generation TRK Inhibitors against Acquired Drug Resistance Mutations for the Treatment of Solid Tumors.
Xu Z, Liu Y, Wang P, Peng X, Cheng J, Ji Y, Li X, Lin D, Zhao J, Chen S, Xu Z, Zheng M, Geng M, Liu H, Ai J, Li C
Journal of medicinal chemistry 2025 Jun 12;68(11):11484-11501
Journal of medicinal chemistry 2025 Jun 12;68(11):11484-11501
Tetraspanin CD37 regulates platelet hyperreactivity and thrombosis.
Sowa MA, Hannemann C, Pinos I, Ferreira E, Biwas B, Dai M, Corr EM, Cornwell MG, Drenkova K, Lee AH, Spruill T, Reynolds HR, Hochman JS, Ruggles KV, Campbell RA, van Solingen C, Wright MD, Moore KJ, Berger JS, Barrett TJ
Cardiovascular research 2025 Jun 12;121(6):943-956
Cardiovascular research 2025 Jun 12;121(6):943-956
Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model.
Gu J, Liu C, Li Y, Feng L, Geng M, Dong J, Han J, Zhao L, Shao Q, Wang HY, Wang CH
Behavioral and brain functions : BBF 2025 Jun 11;21(1):16
Behavioral and brain functions : BBF 2025 Jun 11;21(1):16
Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation.
Chen X, Wang Y, Liu Z, He Y, Gao H, Guan X, Chen L, Chen S, Xing X, Chen W, Li D, Wang Q
Ecotoxicology and environmental safety 2025 Jun 1;297:118224
Ecotoxicology and environmental safety 2025 Jun 1;297:118224
Small molecule- and cell contact-inducible systems for controlling expression and differentiation in mouse embryonic stem cells.
Soliman SS, Shah DH, El-Samad H, Weinberg ZY
Development (Cambridge, England) 2025 Jun 1;152(11)
Development (Cambridge, England) 2025 Jun 1;152(11)
Protective effect of CACNA1A deficiency in oligogenic refractory epilepsy with CACNA1A-CELSR2 digenic mutations.
Liu CQ, Sun MZ, Lin YM, Zhang XX, Huang RN, He MF, Luo S, Luo SY, Huang T, Jiang N, Luo J, Zhang JX, Chen PR, Dai X, Han TA, Liao WP, Peng RC, Qiao JD
Epilepsia 2025 Jul;66(7):2391-2406
Epilepsia 2025 Jul;66(7):2391-2406
Extracellular GMFB activates the non-canonical FAS-FAF1 pathway to induce lysosomal dysfunction in early diabetic retinopathy.
Liu C, Gao F, Zhu L, Sun W, Zhu T, Shi S, Wang J, Ou Q, Xu JY, Li J, Xu J, Jia S, Bi Y, Jin C, Tian H, Xu GT, Lu L
International journal of biological macromolecules 2025 Jul;318(Pt 1):145082
International journal of biological macromolecules 2025 Jul;318(Pt 1):145082
P-Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating TLR4/MyD88/NF-κB-Mediated Inflammation and Oxidative Stress.
Wang H, Zhang C, He J, He Z, Yan S, Zhang Y, Huang S, Yan Y, Chen Y, Xian Z, Hu R, Wang Y, Xiao W, Wang M
Journal of cellular and molecular medicine 2025 Jul;29(14):e70659
Journal of cellular and molecular medicine 2025 Jul;29(14):e70659
Lemborexant ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy.
Parhizkar S, Bao X, Chen W, Rensing N, Chen Y, Kipnis M, Song S, Gent G, Tycksen E, Manis M, Lee C, Serrano JR, Bosch ME, Franke E, Yuede CM, Landsness EC, Wong M, Holtzman DM
Nature neuroscience 2025 Jul;28(7):1460-1472
Nature neuroscience 2025 Jul;28(7):1460-1472
Activation of toll-like receptor 2 promotes the expression of inflammatory mediators and cell proliferation of human polycystic kidney disease cells.
Zhang Y, Plansinis M, Peak S, Weber E, Wei A, Xu Y, Ross M, Leagjeld A, Wallace DP, Zhang Y
Cellular signalling 2025 Jul;131:111749
Cellular signalling 2025 Jul;131:111749
LAG3 limits regulatory T cell proliferation in α-synuclein gut-to-brain transmission model.
Kong WX, Zhang ZL, Li J, Zhu S, Li C, Dong XL, Gan TT, Hu D, Liang FC, Xu PY, Guo WY
Journal of neuroinflammation 2025 Jul 5;22(1):174
Journal of neuroinflammation 2025 Jul 5;22(1):174
Adipocyte CLDN5 promotes thermogenesis and energy expenditure through regulation of IL10 expression.
Feng K, Wang W, Gao X, Yan H, Xu M, Fan B, Jia Q, Wang C, Yu J, Li Y, Xu Q, An Y, Jiao P, Wang M, Sun H, Kong F, Gong Y, Zhao S
Nature communications 2025 Jul 4;16(1):6151
Nature communications 2025 Jul 4;16(1):6151
Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice.
Liu S, Sun H, Du Z, Lu S, Wang C, Zhang Y, Luo Z, Wang L, Fan Z, Wei P, Yan Y, Zhang J, Yin S, Liu T, He Q, Guo X, Ding K, Zhou J, Hua H, Yu C, Xu W, Shan J, Li Y, Xu Y, Shen X, Cao G, Zhou W
Nature communications 2025 Jul 30;16(1):6983
Nature communications 2025 Jul 30;16(1):6983
Structural insights into the human system y(+)L amino acid transporter complex.
Dai L, Xu K, Zhang T, Wang X, Zeng Q, Liang H, Xu C, Yang L, Wang Z, Yan R
Structure (London, England : 1993) 2025 Jul 3;33(7):1224-1232.e5
Structure (London, England : 1993) 2025 Jul 3;33(7):1224-1232.e5
Construction and validation of acetylation-related gene signatures for immune landscape analysis and prognostication risk prediction in luminal breast cancer.
Zhu M, Lin J, Liu H, Wang J, Liu N, Li Y, Lai H, Shi Q
Cancer cell international 2025 Jul 28;25(1):287
Cancer cell international 2025 Jul 28;25(1):287
Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.
Sinha IR, Sandal PS, Spence H, Burns GD, Mallika AP, Abbasinejad F, Irwin KE, Cruz ALF, Wang V, Marx SR, Rodríguez JL, Langmead B, Gregory JM, Wong PC, Ling JP
Nature communications 2025 Jul 25;16(1):6878
Nature communications 2025 Jul 25;16(1):6878
Calycosin inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by downregulating early growth response 1.
Liu Y, Wang J, Cheng SW, Chen X, Bai Z, Zhou YH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156884
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156884
Xingxiao pills suppresses lung adenocarcinoma progression by modulating lipid metabolism and inhibiting the PLA2G4A-GLI1-SOX2 Axis.
Fang X, Li J, Pang H, Zheng H, Shi X, Feng L, Hu K, Zhou T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156826
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156826
Hedyotis chrysotricha aqueous extract inhibits hepatitis B surface antigen and viral replication via hepatocyte nuclear factor 4α regulation.
Yu Y, Hu H, Zhang Y, Zhang Z, Ying S, Dong S, Dai J, Hong Y, Qiu Y, Lou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156726
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156726
Comprehensive two-dimensional primary hepatic stellate cell (HSC) membrane chromatography-based screening of anti-fibrotic components from Schisandra chinensis (Turcz.) Baill. and mechanistic insights into gomisin N against liver fibrosis.
Liu F, Li S, Gu Y, Chen P, Yao R, Wang S, Wang L, Wang R, Yuan Y
Journal of ethnopharmacology 2025 Jul 24;351:120067
Journal of ethnopharmacology 2025 Jul 24;351:120067
The Expression Pattern of the Splice Variants of Coxsackievirus and Adenovirus Receptor Impacts CV-B3-Induced Encephalitis and Myocarditis in Neonatal Mice.
Zhang X, Zhang X, Zhang Y, Li H, Zheng H, Wang J, Liao Y, Yu L, Li D, Zhao H, Li J, Zhang Z, Shi H, Liu L
International journal of molecular sciences 2025 Jul 24;26(15)
International journal of molecular sciences 2025 Jul 24;26(15)
Novel Folate-Phenylfuran P-gp Inhibitor Conjugates for Overcoming Multidrug Resistance in MCF-7/ADR Cell.
Wang Q, Yang N, Yan H, Zhu Y, Zhang Q, Zhu R, Yang Y, Yu L, Liu Y, Li J, Li Y
ChemMedChem 2025 Jul 1;20(13):e202500216
ChemMedChem 2025 Jul 1;20(13):e202500216
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression.
Wang M, Wen X, Feng Z, Choubey M, Chen S, Pan R, Gong K, Tirumalasetty MB, Gao F, Liao C, Yin Z, Zhang S, He Y, Chen H, Cao Y, Miao QR, Hu W, Duan Y
Nature communications 2025 Jul 1;16(1):5491
Nature communications 2025 Jul 1;16(1):5491
Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway.
Yang HQ, Li ZW, Dong XX, Zhang JX, Shan J, Wang MJ, Yang J, Li MH, Wang J, Zhao HM
Acta pharmacologica Sinica 2025 Jan;46(1):96-106
Acta pharmacologica Sinica 2025 Jan;46(1):96-106
RNA-seq shows Angiopoietin-like 4 promotes hepatocellular carcinoma progression by inducing M2 polarization of tumor-associated macrophages.
Cui G, Liu W, Sun X, Bai Y, Ding M, Zhao N, Guo J, Qu D, Wang S, Qin L, Yang Y
International journal of biological macromolecules 2025 Jan;287:138523
International journal of biological macromolecules 2025 Jan;287:138523
Aberrant TCF21 upregulation in adenomyosis impairs endometrial decidualization by increasing PDE4C expression.
Yu R, Wei C, Li G, Ouyang J, Liu N, Gu N, Lin Y, Xu H
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167526
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167526
Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.
Wang J, Liao L, Miao B, Yang B, Li B, Ma X, Fitz A, Wu S, He J, Zhang Q, Ji S, Jin G, Zhang J, Cao Y, Wang H, Qin W, Sun C, Bernards R, Wang C
Proceedings of the National Academy of Sciences of the United States of America 2025 Jan 7;122(1):e2419625121
Proceedings of the National Academy of Sciences of the United States of America 2025 Jan 7;122(1):e2419625121
CHI-KAT8i5 suppresses ESCC tumor growth by inhibiting KAT8-mediated c-Myc stability.
Zhang D, Jiang M, Li P, Laster KV, Zhao D, Zhi Y, Wei H, Nie W, Gao Y, Wu Q, Xiang P, He X, Liu K, Dong Z
Cell reports 2025 Jan 28;44(1):115135
Cell reports 2025 Jan 28;44(1):115135
In-depth immune profiling of a patient with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2 caused by a novel mutation in ZBTB24.
Roark CM, Ramírez-Vásquez D, Giron Martinez JY, Zhen X, Del Bene AN, Gibson SE, Dobrose MM, Halasa NB, Blancas-Galicia L, Martinez-Barricarte R
Clinical and experimental immunology 2025 Jan 21;219(1)
Clinical and experimental immunology 2025 Jan 21;219(1)
Tumor-Specific Antigen Delivery for T-cell Therapy via a pH-Sensitive Peptide Conjugate.
Yurkevicz AM, Liu Y, Katz SG, Glazer PM
Molecular cancer therapeutics 2025 Jan 2;24(1):105-117
Molecular cancer therapeutics 2025 Jan 2;24(1):105-117
Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression.
Pang J, Huang X, Gao Y, Guan X, Xiong L, Li L, Yin N, Dai M, Han T, Yi W
Scientific reports 2025 Jan 2;15(1):56
Scientific reports 2025 Jan 2;15(1):56
Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines.
Zhang D, Zou Y, Wu J, Xu L, Ke Z, Wu Y, Zhou Z, Fang M, Chen L, Xu H, Chu J, Xia N, Zhu R, Cheng T
Virology journal 2025 Jan 17;22(1):12
Virology journal 2025 Jan 17;22(1):12
Persistent Neutrophilic Inflammation is Associated with Delayed Toxicity of Phenylarsine Oxide in Lungs.
Sanchez NC, Mani G, Jones C, Zmijewsli JW, Surolia R
Research square 2025 Jan 13;
Research square 2025 Jan 13;
Downregulation of MLF1 safeguards cardiomyocytes against senescence-associated chromatin opening.
Lv J, Chen Q, Wang J, Guo N, Fang Y, Guo Q, Li J, Ma X, Zhan H, Chen W, Wang L, Yan Q, Tong J, Wang Z
Nucleic acids research 2025 Jan 11;53(2)
Nucleic acids research 2025 Jan 11;53(2)
Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4.
Medina-Suárez D, Han L, O'Reilly S, Liu J, Wei C, Brenière M, Goff NJ, Chen C, Modesti M, Meek K, Harrington B, Yu K
Nucleic acids research 2025 Jan 11;53(2)
Nucleic acids research 2025 Jan 11;53(2)
Dopamine D3 receptor mediates natural and methamphetamine rewards via regulating the expression of miR-29c in the nucleus accumbens of mice.
Wang R, Zhu L, Fan Y, Du H, Han W, Guan F, Zhu Y, Ni T, Chen T
Neuropharmacology 2025 Jan 1;262:110200
Neuropharmacology 2025 Jan 1;262:110200
Novel Diagnostic Biomarker BST2 Identified by Integrated Transcriptomics Promotes the Development of Endometriosis via the TNF-α/NF-κB Signaling Pathway.
Jiang L, Wang S, Xia X, Zhang T, Wang X, Zeng F, Ma J, Fang X
Biochemical genetics 2025 Feb;63(1):354-377
Biochemical genetics 2025 Feb;63(1):354-377
An OMV-Based Nanovaccine as Antigen Presentation Signal Enhancer for Cancer Immunotherapy.
Lu Y, Ma N, Cheng K, Liu G, Liang J, Xu C, Li D, Cao C, Gao X, Chen L, Wang X, Wang Y, Zhao X, Jiang K
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(8):e2413392
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(8):e2413392
RTN4IP1 Contributes to ESCC via Regulation of Amino Acid Transporters.
Wei H, Zhao D, Zhi Y, Wu Q, Ma J, Xu J, Liu T, Zhang J, Wang P, Hu Y, He X, Guo F, Jiang M, Zhang D, Nie W, Yang R, Zhao T, Dong Z, Liu K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2406220
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2406220
A missense variant in the SOX5 gene (c.221C > T) is associated with intellectual disability.
Yang X, Gan Z, Guo X, Huang X, Liu J, Zheng Y, Zhou X, Lian J, Liu Y, Yang T, Li C, Chen F, He F, Xu X, Zhou Y, Liu Q, Yang X, Xiong F
Orphanet journal of rare diseases 2025 Feb 4;20(1):50
Orphanet journal of rare diseases 2025 Feb 4;20(1):50
Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling.
Xu ZY, Gao JS, He Y, Xiao XQ, Gong GZ, Zhang M
World journal of hepatology 2025 Feb 27;17(2):99292
World journal of hepatology 2025 Feb 27;17(2):99292
Identification of the B7-H3 Interaction Partners Using a Proximity Labeling Strategy.
Liao S, Huang J, Lupala CS, Li X, Li X, Li N
International journal of molecular sciences 2025 Feb 18;26(4)
International journal of molecular sciences 2025 Feb 18;26(4)
The structural discrepancy between the ability of fructan and arabinogalactan to cure acute pharyngitis in Hosta plantaginea (Lam.) Aschers flowers.
Bai T, Bao S, Li Y, Hou X, Pan S, Wang H, Zhao Y, Liddle M, Li H, Bai L, Xiao X
Carbohydrate polymers 2025 Feb 15;350:123059
Carbohydrate polymers 2025 Feb 15;350:123059
FGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice.
Zhang K, Gan J, Wang B, Lei W, Zhen D, Yang J, Wang N, Wen C, Gao X, Li X, Xu A, Liu X, Li Y, Wu F, Lin Z
Nature communications 2025 Feb 15;16(1):1661
Nature communications 2025 Feb 15;16(1):1661
Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway.
He Y, Huang C, Chen J, Shen W
Heliyon 2025 Feb 15;11(3):e42159
Heliyon 2025 Feb 15;11(3):e42159
Cystinosin is involved in Na(+)/H(+) Exchanger 3 trafficking in the proximal tubular cells: new insights in the renal Fanconi syndrome in cystinosis.
Khare V, Farre JC, Rocca C, Kbaich MA, Tang C, Ma X, Beiderman K, Mathur I, Badell-Grau RA, Sivakumar A, Chen R, Catz SD, Cherqui S
bioRxiv : the preprint server for biology 2025 Feb 12;
bioRxiv : the preprint server for biology 2025 Feb 12;
Corydalis decumbens and tetrahydropalmatrubin inhibit macrophages inflammation to relieve rheumatoid arthritis by targeting Fosl2.
Gao P, Yuan S, Wang Y, Wang Y, Li X, Liu T, Zheng Y, Wang J, Liu D, Xu L, Jiang Y, Zeng K, Tu P
Journal of ethnopharmacology 2025 Feb 11;341:119348
Journal of ethnopharmacology 2025 Feb 11;341:119348
β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the MAPK and STAT3 signaling pathways.
Fu Z, Liu H, Kuang Y, Yang J, Luo M, Cao L, Zheng W
Journal of ethnopharmacology 2025 Feb 11;341:119344
Journal of ethnopharmacology 2025 Feb 11;341:119344
Ferroptotic Neutrophils Induce Immunosuppression and Chemoresistance in Breast Cancer.
Zeng W, Zhang R, Huang P, Chen M, Chen H, Zeng X, Liu J, Zhang J, Huang D, Lao L
Cancer research 2025 Feb 1;85(3):477-496
Cancer research 2025 Feb 1;85(3):477-496
Disruption of the gut microbiota induces the LCA/TRPV6 signalling axis, impairing desmosome junctions in vitamin A-deficient rats.
Yan J, Wang Y, Tong B, Yuan B, Miao Y, Yang T, Sun Z, Wang Y, Chen J
Food research international (Ottawa, Ont.) 2025 Dec;222(Pt 1):117656
Food research international (Ottawa, Ont.) 2025 Dec;222(Pt 1):117656
Loss of CDS1 impairs the tumorigenic characteristics of nasopharyngeal carcinoma by modulating lipid metabolism.
Wang Y, Li L, Matskova L, Deng L, Li D, Huang Y, Liang H, Wang W, Liang Z, Su J, Zhao W, Huang T, Chu J, Zhang Z, Xiao X, Zhou X
Cell adhesion & migration 2025 Dec;19(1):2520629
Cell adhesion & migration 2025 Dec;19(1):2520629
Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila.
Pan M, Qian C, Huo S, Wu Y, Zhao X, Ying Y, Wang B, Yang H, Yeerken A, Wang T, Fu M, Wang L, Wei Y, Zhao Y, Shao C, Wang H, Zhao C
Gut microbes 2025 Dec;17(1):2447834
Gut microbes 2025 Dec;17(1):2447834
Heterophyllin B alleviates diabetes-induced myocardial injury by regulating MAVS-mediated mitochondrial homeostasis.
Li L, Liu Z, Hu H, Wang Q, Wang J, Jin L, Zhang S, Wei J, Zhao L, Chen Z, Liu Q, Zhu K, Zhang L
The Journal of nutritional biochemistry 2025 Dec;146:110075
The Journal of nutritional biochemistry 2025 Dec;146:110075
Serum multiomics prediction of prognosis and adverse reactions to concurrent chemoradiotherapy in patients with esophageal cancer.
Wu WZ, Huang HC, Zhu GH, Liao LD, Chen XL, Li ZM, Chu MY, Yu SX, Wang D, Li EM, Xu LY
British journal of cancer 2025 Dec;133(12):1829-1843
British journal of cancer 2025 Dec;133(12):1829-1843
Single-Cell Transcriptomics Reveals ITGA2-Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis.
Zhan ZJ, Li N, Sun Y, Chen L, Yin JD, Shan YH, Zeng JX, Li ZC, Tan HL, Tang N, Chang S, Huang P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e04088
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e04088
Cysteine-S-nitrosylation inhibits Rop5-mediated immune evasion in Toxoplasma gondii.
Lempke SL, DiMare PC, Nichols B, Chaudry AM, Fitzsimmons LF, Reese ML, Ewald SE
bioRxiv : the preprint server for biology 2025 Dec 8;
bioRxiv : the preprint server for biology 2025 Dec 8;
Loss of ADAM15 prevents necroptosis induction by partial RIPK1 degradation due to enhanced TNF-R1 surface expression and basal caspase-8 activation.
Braun S, Knackfuß K, Ziesmann T, Mlinzk L, Goerg A, Frankenheim J, Walter A, Schneider-Brachert W, Distler U, Fritsch J
Cell communication and signaling : CCS 2025 Dec 4;23(1):520
Cell communication and signaling : CCS 2025 Dec 4;23(1):520
Cholestanol promotes tau pathology in a mouse model of tauopathy.
Yu T, Li Y, Li S, Nie S, Feng H, Zhang Z, Meng L
Cellular and molecular life sciences : CMLS 2025 Dec 24;83(1):5
Cellular and molecular life sciences : CMLS 2025 Dec 24;83(1):5
RICH1 enhances pro-inflammatory TAM infiltration in breast cancer via promoting TRIM21-mediated ubiquitination of RhoA and inhibiting STAT3 phosphorylation.
Zhou Y, Gao H, Shan L, Zhu L, Yang J, Wang B, Zhang J, Ran R, Tian Q, Liu P, Yang J
NPJ precision oncology 2025 Dec 23;10(1):49
NPJ precision oncology 2025 Dec 23;10(1):49
A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL.
Mandleywala K, Ulrich S, da Silva-Diz V, Sharma P, Thai C, Kim O, Aleksandrova M, Chung G, Eggers C, Lütjohann D, Kulkarni T, Singh A, Elena Díaz-Rubio M, Wierer M, Leidel SA, Su X, White EP, Rabinowitz JD, Morscher RJ, Herranz D
bioRxiv : the preprint server for biology 2025 Dec 23;
bioRxiv : the preprint server for biology 2025 Dec 23;
7-Ketolithocholic Acid Exerts Anti-Renal Fibrotic Effects Through FXR-Mediated Inhibition of TGF-β/Smad and Wnt/β-Catenin Pathways.
Guo Q, Peng L, Zhang J, Hu J, Wang Y, Wei J, Zhang Z
Pharmaceuticals (Basel, Switzerland) 2025 Dec 21;19(1)
Pharmaceuticals (Basel, Switzerland) 2025 Dec 21;19(1)
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression.
Li C, Lu Y, Li Y, Liu T, Deng H, Gao M, Zhou B, Liu J, Cai J, Huang D, Yang L, Jin J, Kuang D, Su S
Cell metabolism 2025 Dec 2;37(12):2402-2422.e18
Cell metabolism 2025 Dec 2;37(12):2402-2422.e18
SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1α-XBP1 Signaling Under ER Stress.
Ying Q, Chen Y, Shen L, Xu Y, Tian R
Nature communications 2025 Dec 19;17(1):911
Nature communications 2025 Dec 19;17(1):911
Clostridium scindens attenuates acute kidney injury by producing indole-3-acetic acid.
Cao YZ, Li JY, Hu JM, Su K, Chen JL, Liu Y, Wei JL, Zhang ZH
NPJ biofilms and microbiomes 2025 Dec 15;12(1):16
NPJ biofilms and microbiomes 2025 Dec 15;12(1):16
Nano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis.
Chen Z, Zhu Q, Xu H, Hu Y, Wang Y, Chen Z, Wang Y, Huang X, Fu G, Ma B, Zhang W
Nature communications 2025 Dec 13;16(1):11294
Nature communications 2025 Dec 13;16(1):11294
Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation.
Wang S, Li W, Wen J, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM
mBio 2025 Dec 10;16(12):e0293025
mBio 2025 Dec 10;16(12):e0293025
Exposure to submicroplastics promotes the progression of nonalcoholic fatty liver disease in ApoE-deficient mice.
Li Q, Niu X, Cai Y, Li L, Xia Z
Toxicology 2025 Aug;515:154137
Toxicology 2025 Aug;515:154137
From Spheroid to Sprouting: Microenvironmental Modulation Boosts Hair Follicle Organoid Morphogenesis in 3D Culture.
Xiao L, Tang Y, Zhang F, Zhang J
Cell biology international 2025 Aug;49(8):939-951
Cell biology international 2025 Aug;49(8):939-951
KW-2449 Ameliorates Cardiac Dysfunction in a Rat Model of Sepsis-Induced Cardiomyopathy.
Chen J, Zhang WJ, Liu XY, Hu TP, Gao N, Li ZH, Wang Y, Zhang GQ
Inflammation 2025 Aug;48(4):2732-2744
Inflammation 2025 Aug;48(4):2732-2744
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine.
Fan PL, Lai HQ, Wang HY, Hu KC, Ruan Y, Ye JR, Wang SS, Peng Y, He WB, Li G, Yan X, Chu SF, Zhang Z, Chen NH
Cell death and differentiation 2025 Aug;32(8):1499-1517
Cell death and differentiation 2025 Aug;32(8):1499-1517
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development.
Lu Y, Wei S, Wang S, Zhang J, Xu Y, Huang C, Pan W, Wang Z
Molecular medicine reports 2025 Aug;32(2)
Molecular medicine reports 2025 Aug;32(2)
Gastrodin Attenuates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitochondrial Fusion and Activating the AMPK-OPA1 Signaling Pathway.
Liu Z, Han Z, Bao W, Guo Y, Yuan Y, Cheng J, Zhang J, Hu Y
CNS neuroscience & therapeutics 2025 Aug;31(8):e70559
CNS neuroscience & therapeutics 2025 Aug;31(8):e70559
GmFER1, a soybean ferritin, enhances tolerance to salt stress and root rot disease and improves soybean yield.
Zhang Y, Liu S, Liang X, Zheng J, Lu X, Zhao J, Li H, Zhan Y, Teng W, Li H, Han Y, Zhao X, Li Y
Plant biotechnology journal 2025 Aug;23(8):3094-3112
Plant biotechnology journal 2025 Aug;23(8):3094-3112
α6GABA(A) receptor positive allosteric modulators targeting trigeminal ganglia for preventing and aborting chronic periorbital allodynia and cephalic pain in both sexes: A mechanistic and comparative preclinical study.
Chang XC, Yeh CJ, Pan YT, Chen YP, Sharmin D, Cook J, Pei YC, Chiou LC
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118344
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118344
Paraoxonase 3 regulates the pore-forming α subunit of the large-conductance K(+) channel.
Whelan SCM, Nickerson AJ, Montalbetti N, Mutchler SM, Carattino MD, Kleyman TR, Shi S
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119990
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119990
IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.
Li J, Wang M, Qu K, Sun Y, Yin Z, Dong N, Sun X, Xu Y, Chen L, Zhang S, Xian X, Xu S, Ma L, Duan Y, Zhu H
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4047-4063
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4047-4063
Ligand supplementation restores the cancer therapy efficacy of the antirheumatic drug auranofin from serum inactivation.
Wang Y, Cao B, Wang Q, Zhong S, Fang X, Wang J, Chan ASC, Xiong X, Zou T
Nature communications 2025 Aug 9;16(1):7347
Nature communications 2025 Aug 9;16(1):7347
PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules.
Huang C, Huang J, Lu R, Yu AJ, Yu AS, Cao Y, Li L, Li J, Li H, Zhou Z, Zhang Y, Xu A, Chen R, Wang Y, Zhao X, Huang J, Fu Y, Xu M, Zhang H, Yu J
Nature communications 2025 Aug 7;16(1):7308
Nature communications 2025 Aug 7;16(1):7308
Rescue of male infertility by human PRSS55 in transgenic mice establishes a contraceptive research model.
Sutton CM, Umezu K, Mashiko D, Ikawa M, Larina IV, Garcia TX, Matzuk MM
Scientific reports 2025 Aug 5;15(1):28657
Scientific reports 2025 Aug 5;15(1):28657
WEE1 inhibitor exerts synergistic effect with KRAS G12C inhibitor via MYBL2-RRM2 axis in KRAS(G12C)-mutant lung cancer.
Zhou C, Liu Y, Liu H, Lu J, Zhang B, Zhu L, Wang S, Lei H, Han B
Cell death & disease 2025 Aug 30;16(1):661
Cell death & disease 2025 Aug 30;16(1):661
Mechanisms and synergistic effects of the active components of Xanthocerais lignum in inhibiting rheumatoid arthritis through the modulation of the biological behavior of synovial cells.
Qian H, Bai C, Jia X, Yang Y, Tian X, Wang X
Journal of ethnopharmacology 2025 Aug 29;352:120200
Journal of ethnopharmacology 2025 Aug 29;352:120200
BAOXIN granules reverse ferroptosis through the solute carrier family 7 member -glutathione-glutathione peroxidase 4 axis in ischemia-induced heart failure in rats.
Xu J, Li Y, Pan F, Cao S, Wang M, Chen Y, Wang Y, Yang Y, Wu H, Huang Y, Tian J
Journal of ethnopharmacology 2025 Aug 29;352:120119
Journal of ethnopharmacology 2025 Aug 29;352:120119
NAD(+) Metabolism-Mediated SURF4-STING Axis Enhances T-Cell Anti-Tumor Effects in the Ovarian Cancer Microenvironment.
Shen J, Xu F, Liu T, Ye Y, Xu S
Cell death & disease 2025 Aug 23;16(1):640
Cell death & disease 2025 Aug 23;16(1):640
Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4(QTY)-Fc as a molecular trap.
Sun C, Hao S, Wang L, Meng R, Wang H, Li W, Deng J, Yin Q, Chen X, Xiang T, Liu Z, Zheng H, Luo Z, Cai K, Wang B, Zhang S, Qing R
Cell chemical biology 2025 Aug 21;32(8):1058-1074.e6
Cell chemical biology 2025 Aug 21;32(8):1058-1074.e6
The EMC acts as a chaperone for membrane proteins.
Klose CJ, Meighen-Berger KM, Kulke M, Parr M, Steigenberger B, Zacharias M, Frishman D, Feige MJ
Nature communications 2025 Aug 2;16(1):7097
Nature communications 2025 Aug 2;16(1):7097
Cardamonin inhibits the growth and stemness of osteosarcoma stem cells by inducing autophagy and inhibiting the Wnt/β-catenin signaling pathway.
Zhang L, Jin Y, Ding Q, Li Y, Yang L, Li M, Lv Z, Wang K, Yang M, Zhang H, Li X
Scientific reports 2025 Aug 12;15(1):29484
Scientific reports 2025 Aug 12;15(1):29484
Interleukin-10 augments human endogenous retroviral E1B variant of cd5 in aged T cells.
Singh B, Kumari S, Kureel AK, Shah A, Katiyar S, Chaturvedi CP, Singh K, Rai AK
Blood research 2025 Aug 11;60(1):43
Blood research 2025 Aug 11;60(1):43
Loss of TDP-43 Splicing Repression Occurs in Myonuclei of Inclusion Body Myositis Patients.
Ikenaga C, Wilson AB, Irwin KE, Peethambaran Mallika A, Kilgore C, Sinha IR, Michelle EH, Ling JP, Wong PC, Lloyd TE
Annals of neurology 2025 Apr;97(4):629-641
Annals of neurology 2025 Apr;97(4):629-641
Complement Receptor 1 Is a Potential Extracerebral Factor Promoting α-Synuclein Pathology.
Yang Y, Chen S, Gao Y, Huang L, Liu Z, Liu C, Fang X, Zhang Z
Molecular neurobiology 2025 Apr;62(4):4605-4616
Molecular neurobiology 2025 Apr;62(4):4605-4616
Transforming Growth Factor Beta2 Promotes Migration and Inhibits the Proliferation of Gastric Cancer Cells by Regulating the pSmad2/3-NDRG1 Signaling Pathway.
He FJ, Chen XL, Zhu YF, Pang HY, Li ZD, Liang PP, Jin T, Chen ZW, Chen ZH, Hu JK, Yang K
MedComm 2025 Apr;6(4):e70148
MedComm 2025 Apr;6(4):e70148
Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury.
Dong Y, Liu G, Situ X, Xia L, Zhang T, Zhu X, Jin H, Liu Y, Shou S
Inflammation 2025 Apr;48(2):696-712
Inflammation 2025 Apr;48(2):696-712
A combination of alveolar type 2-specific p38α activation with a high-fat diet increases inflammatory markers in mouse lungs.
Heng CKM, Darlyuk-Saadon I, Liao W, Mohanam MP, Gan PXL, Gilad N, Chan CCMY, Plaschkes I, Wong WSF, Engelberg D
The Journal of biological chemistry 2025 Apr;301(4):108425
The Journal of biological chemistry 2025 Apr;301(4):108425
The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins.
Liu D, Huo XY, Zhang X, Zhang ZR
The Journal of biological chemistry 2025 Apr;301(4):108403
The Journal of biological chemistry 2025 Apr;301(4):108403
Tianqi Yizhi Granule alleviates cognitive dysfunction and neurodegeneration in SAMP8 mice via the PKC/ERK pathway.
Zeng Y, Yang S, Xie Z, Li Q, Wang Y, Xiong Q, Liang X, Lu H, Cheng W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156542
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156542
LINC01235 Promotes Clonal Evolution through DNA Replication Licensing-Induced Chromosomal Instability in Breast Cancer.
Zhang Q, Wang X, Shao Z, Zhang Y, Zhang L, Chen M, Zhou X, Zhu H, Zhou Y, Lu X, Li P, Chi W, Li L, Shao ZM, Huang S, Xue J, Chi Y, Wu J, Xiu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413527
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413527
Persistent neutrophilic inflammation is associated with delayed toxicity of phenylarsine oxide in lungs.
Sanchez NC, Mani G, Nowak JI, Jones C, Kim YI, Sharma NS, Zmijewski JW, Surolia R
Scientific reports 2025 Apr 7;15(1):11840
Scientific reports 2025 Apr 7;15(1):11840
Portal hypertension aggravates Helicobacter pylori induced liver injury in mice via activating pyroptosis pathway.
Hu J, Gao L, Maswikiti EP, Li X, Gu B, Yu Y, Li H, Chen H
Scientific reports 2025 Apr 7;15(1):11820
Scientific reports 2025 Apr 7;15(1):11820
The deubiquitinase YOD1 suppresses tumor progression by stabilizing ZNF24 in clear cell renal carcinoma.
Liu J, Lu Y, Zhu R, Xi P, Yang Z, Zhang Z, Xiong Y, Liu Y, Zhu Q, Sun T, Xie W, Gong B
Cell death & disease 2025 Apr 24;16(1):334
Cell death & disease 2025 Apr 24;16(1):334
Cannabinoid CB(2) receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission.
Xu K, Liu X, Zeng Q, Liu Y, Shan L, Ji L, Wu Y, Wu J, Chen Y, Li Y, Huang S, Jiang C, Hong X, Wu C, Wang Z
Cell reports 2025 Apr 22;44(4):115559
Cell reports 2025 Apr 22;44(4):115559
Impaired unfolded protein response, BDNF and synuclein markers in postmortem dorsolateral prefrontal cortex and caudate nucleus of patients with depression and Parkinson's disease.
Sarriés-Serrano U, Miquel-Rio L, Santana N, Paz V, Sancho-Alonso M, Callado LF, Meana JJ, Bortolozzi A
Progress in neuro-psychopharmacology & biological psychiatry 2025 Apr 2;138:111299
Progress in neuro-psychopharmacology & biological psychiatry 2025 Apr 2;138:111299
Mechanistic evaluation of Jiu Wei Qing Zhi Gao in non-alcoholic fatty liver disease: insights from network Pharmacology and experimental validation.
Chen Q, Hu Q, Zhang F, Lu W, Yuan Z, Qiao F
Hereditas 2025 Apr 12;162(1):59
Hereditas 2025 Apr 12;162(1):59
The vitamin D(3) hormone, 1,25(OH)(2)D(3), regulates fibroblast growth factor 23 (FGF23) production in human skin cells.
Ewendt F, Janjetovic Z, Kim TK, Mobley AA, Brożyna AA, Ravichandran S, Fabisiak A, Brzeminski P, Sicinski RR, Stangl GI, Tuckey RC, Slominski AT
American journal of physiology. Cell physiology 2025 Apr 1;328(4):C1177-C1192
American journal of physiology. Cell physiology 2025 Apr 1;328(4):C1177-C1192
The FTO Mediated N6-Methyladenosine Modification of DDIT4 Regulation with Tumorigenesis and Metastasis in Prostate Cancer.
Zhao Y, Hu X, Yu H, Sun H, Zhang L, Shao C
Research (Washington, D.C.) 2024;7:0313
Research (Washington, D.C.) 2024;7:0313
Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells.
Zi G, Chen J, Peng Y, Wang Y, Peng B
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2024;41(1):2325489
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2024;41(1):2325489
Construction of the miRNA/Pyroptosis-Related Molecular Regulatory Axis in Abdominal Aortic Aneurysm: Evidence From Transcriptome Data Combined With Multiple Machine Learning Approaches Followed by Experiment Validation.
Su Y, Lu C, Chen S
Journal of immunology research 2024;2024:1429510
Journal of immunology research 2024;2024:1429510
Ruxolitinib-based senomorphic therapy mitigates cardiomyocyte senescence in septic cardiomyopathy by inhibiting the JAK2/STAT3 signaling pathway.
Yang B, Li T, Wang Z, Zhu Y, Niu K, Hu S, Lin Z, Zheng X, Jin X, Shen C
International journal of biological sciences 2024;20(11):4314-4340
International journal of biological sciences 2024;20(11):4314-4340
PKCα Induced the Generation of Extracellular Vesicles in Activated Platelets to Promote Breast Cancer Metastasis.
Zhao J, Tian H, Zhao X, Lan L, Liu H, Sun Y, Yu F
International journal of biological sciences 2024;20(10):3956-3971
International journal of biological sciences 2024;20(10):3956-3971
Stimuli-Responsive Peptide/siRNA Nanoparticles as a Radiation Sensitizer for Glioblastoma Treatment by Co-Inhibiting RELA/P65 and EGFR.
Cen B, Zhang J, Pan X, Xu Z, Li R, Chen C, Wang B, Li Z, Zhang G, Ji A, Yuan Y
International journal of nanomedicine 2024;19:11517-11537
International journal of nanomedicine 2024;19:11517-11537
Menaquinone-4 Alleviates Sepsis-Associated Acute Lung Injury via Activating SIRT3-p53/SLC7A11 Pathway.
Gao N, Liu XY, Chen J, Hu TP, Wang Y, Zhang GQ
Journal of inflammation research 2024;17:7675-7685
Journal of inflammation research 2024;17:7675-7685
CORM-3 Inhibits the Inflammatory Response of Human Periodontal Ligament Fibroblasts Stimulated by LPS and High Glucose.
Tian H, Chen H, Yin X, Lv M, Wei L, Zhang Y, Jia S, Li J, Song H
Journal of inflammation research 2024;17:4845-4863
Journal of inflammation research 2024;17:4845-4863
Knockdown of LRP5 Promotes Proliferation and Invasion of Tongue Squamous Cell Carcinoma through Compensatory Activation of Akt Signaling.
Wang C, Li Y, Miao X, Wang Y, Yang G
Journal of Cancer 2024;15(10):3215-3226
Journal of Cancer 2024;15(10):3215-3226
Yinqin Qingfei granules alleviate Mycoplasma pneumoniae pneumonia via inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis.
Song Z, Han C, Luo G, Jia G, Wang X, Zhang B
Frontiers in pharmacology 2024;15:1437475
Frontiers in pharmacology 2024;15:1437475
Baitouweng decoction alleviates ulcerative colitis by regulating tryptophan metabolism through DOPA decarboxylase promotion.
Zhang J, Lin B, Zhang Y, Hu X, Liu T, Liu EH, Liu S
Frontiers in pharmacology 2024;15:1423307
Frontiers in pharmacology 2024;15:1423307
FLNB overexpression promotes tumor progression and associates with immune suppression, evasion and stemness in pancreatic cancer.
Fan G, Yan Q, Chen Y, Han M, Wu Z, Ruan S, Zhuang H, Gou Q, Hou B
American journal of cancer research 2024;14(2):709-726
American journal of cancer research 2024;14(2):709-726
Intraductal photothermal ablation: a noninvasive approach for early breast cancer treatment and prevention.
Liu J, Huang B, Rao Y, Guo L, Cai C, Gao D, Kong D, Wang G, Xiong Y, Cui R, Zhang M, Chen C
Theranostics 2024;14(10):3997-4013
Theranostics 2024;14(10):3997-4013
Altered expression of the Plexin-B2 system in tuberous sclerosis complex and focal cortical dysplasia IIb lesions.
Dai L, Huang J, Shen KF, Yang XL, Zhu G, Zhang L, Wang ZK, Liu SY, Liao X, Xu SL, Yang H, Li XY, Zhang CQ
Histology and histopathology 2024 Sep;39(9):1179-1195
Histology and histopathology 2024 Sep;39(9):1179-1195
Inhibition of CXCR4: A perspective on miracle fruit seed for Alzheimer's disease treatment.
Huang XY, Xue LL, Ma RF, Shi JS, Wang TH, Xiong LL, Yu CY
Experimental neurology 2024 Sep;379:114841
Experimental neurology 2024 Sep;379:114841
Exploring the role of spinal astrocytes in the onset of hyperalgesic priming signals in acid-induced chronic muscle pain.
Abdelaziz MA, Chen WH, Chang YW, Mindaye SA, Chen CC
PNAS nexus 2024 Sep;3(9):pgae362
PNAS nexus 2024 Sep;3(9):pgae362
Targeting translocator protein protects against myocardial ischemia/reperfusion injury by alleviating mitochondrial dysfunction.
Wen C, Jiang Y, Chen W, Xu Y, Chen G, Zhou Q, Liu Q, Jiang H, Liu Y, Cao X, Yao Y, Zhang R, Qiu Z, Liu S
Experimental and therapeutic medicine 2024 Sep;28(3):349
Experimental and therapeutic medicine 2024 Sep;28(3):349
Unveiling a new strategy for PDIA1 inhibition: Integration of activity-based probes profiling and targeted degradation.
Zhang B, Hong D, Qian H, Ma K, Zhu L, Jiang L, Ge J
Bioorganic chemistry 2024 Sep;150:107585
Bioorganic chemistry 2024 Sep;150:107585
Identification of Matrine as a Kirsten rats Arcomaviral oncogene homolog inhibitor alleviating chemotherapy-induced neuropathic pain.
Zhu C, Zhang M, Gong S, Du J, Ma L, Liu Y, Li Y, Yu J, Liu N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155841
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155841
Multi-omics integration reveals potential stage-specific druggable targets in T-cell acute lymphoblastic leukemia.
Yan Z, Xia J, Cao Z, Zhang H, Wang J, Feng T, Shu Y, Zou L
Genes & diseases 2024 Sep;11(5):100949
Genes & diseases 2024 Sep;11(5):100949
Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
Sorets AG, Schwensen KR, Francini N, Kjar A, Abdulrahman AM, Shostak A, Katdare KA, Schoch KM, Cowell RP, Park JC, Ligocki AP, Ford WT, Ventura-Antunes L, Hoogenboezem EN, Prusky A, Castleberry M, Michell DL, Miller TM, Vickers KC, Schrag MS, Duvall CL, Lippmann ES
bioRxiv : the preprint server for biology 2024 Sep 7;
bioRxiv : the preprint server for biology 2024 Sep 7;
CD9 promotes TβR2-TβR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia.
Huang W, Zhang Z, Li X, Zheng Q, Wu C, Liu L, Chen Y, Zhang J, Jiang X
Molecular medicine (Cambridge, Mass.) 2024 Sep 27;30(1):162
Molecular medicine (Cambridge, Mass.) 2024 Sep 27;30(1):162
Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia.
Xue C, Zeng P, Gong K, Li Q, Feng Z, Wang M, Chen S, Yang Y, Li J, Zhang S, Yin Z, Liang Y, Yan T, Yu M, Feng K, Zhao D, Yang X, Zhang X, Ma L, Iwakiri Y, Chen L, Tang X, Chen Y, Chen H, Duan Y
Cell reports 2024 Sep 24;43(9):114691
Cell reports 2024 Sep 24;43(9):114691
GRP94 promotes anoikis resistance and peritoneal metastasis through YAP/TEAD1 pathway in gastric cancer.
Shi Q, Lu Y, Du Y, Yang R, Guan Y, Yan R, Yu Y, Wang Z, Li C
iScience 2024 Sep 20;27(9):110638
iScience 2024 Sep 20;27(9):110638
A novel super-enhancer-related risk model for predicting prognosis and guiding personalized treatment in hepatocellular carcinoma.
Wu Q, Li P, Tao X, Lin N, Mao B, Xie X
BMC cancer 2024 Sep 2;24(1):1087
BMC cancer 2024 Sep 2;24(1):1087
Nuclear translocation of nucleotide enzyme Phosphoglucomutase 2 governs DNA damage response and anti-tumor immunity.
Lyu Y, Liu C, Lin H, Song H, Zhuang Q, Hu A, Chen L, Yang H, Mao Y
Heliyon 2024 Sep 15;10(17):e36415
Heliyon 2024 Sep 15;10(17):e36415
Cellular origin and clonal evolution of human dedifferentiated liposarcoma.
Gruel N, Quignot C, Lesage L, El Zein S, Bonvalot S, Tzanis D, Ait Rais K, Quinquis F, Manciot B, Vibert J, El Tannir N, Dahmani A, Derrien H, Decaudin D, Bièche I, Courtois L, Mariani O, Linares LK, Gayte L, Baulande S, Waterfall JJ, Delattre O, Pierron G, Watson S
Nature communications 2024 Sep 12;15(1):7941
Nature communications 2024 Sep 12;15(1):7941
Edaravone Maintains AQP4 Polarity Via OS/MMP9/β-DG Pathway in an Experimental Intracerebral Hemorrhage Mouse Model.
Wang Z, Li Y, Wang Z, Liao Y, Ye Q, Tang S, Wei T, Xiao P, Huang J, Lu W
Molecular neurobiology 2024 Oct;61(10):7639-7658
Molecular neurobiology 2024 Oct;61(10):7639-7658
Rsad2 mediates Bisphenol A-induced actin cytoskeletal disruption in mouse spermatocytes.
Jiang X, Sun S, Shi C, Liu K, Yang Y, Cao J, Gu J, Liu J
Journal of applied toxicology : JAT 2024 Oct;44(10):1478-1488
Journal of applied toxicology : JAT 2024 Oct;44(10):1478-1488
The high-bone-mass phenotype of novel transgenic mice with LRP5 A241T mutation.
Wang X, Zhang H, Hu L, He J, Jiang Q, Ren L, Yu K, Fu M, Li Z, He Z, Zhu J, Wang Y, Jiang Z, Yang G
Bone 2024 Oct;187:117172
Bone 2024 Oct;187:117172
Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer.
Tran TTT, Phung CD, Yeo BZJ, Prajogo RC, Jayasinghe MK, Yuan J, Tan DSW, Yeo EYM, Goh BC, Tam WL, Le MTN
EBioMedicine 2024 Oct;108:105356
EBioMedicine 2024 Oct;108:105356
Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma.
Wei E, Mitanoska A, O'Brien Q, Porter K, Molina M, Ahsan H, Jung U, Mills L, Kyba M, Bosnakovski D
Molecular cancer 2024 Oct 5;23(1):222
Molecular cancer 2024 Oct 5;23(1):222
Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis.
Dong X, Yu X, Lu M, Xu Y, Zhou L, Peng T
Cell death discovery 2024 Oct 29;10(1):456
Cell death discovery 2024 Oct 29;10(1):456
Gut Bacteroides ovatus ameliorates renal fibrosis by promoting the production of HDCA through upregulation of Clostridium scindens.
Si ZL, Wang HY, Wang T, Cao YZ, Li QZ, Liu K, Huang Z, Liu HL, Tan YJ, Wang YY, Huang FQ, Ma GX, Alolga RN, Yan M, Chen C, Li JH, Li J, Liu HW, Zhang ZH
Cell reports 2024 Oct 22;43(10):114830
Cell reports 2024 Oct 22;43(10):114830
RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner.
Luo J, Yang C, Xu S, Ji Z, Zhang Y, Bai H, Deng Z, Liang J, Huang Y, Zhi E, Tian R, Li P, Zhao F, Zhou Z, Li Z, Yao C
Communications biology 2024 Oct 21;7(1):1362
Communications biology 2024 Oct 21;7(1):1362
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Yan P, Yang K, Xu M, Zhu M, Duan Y, Li W, Liu L, Liang C, Li Z, Pan X, Wang L, Yu G
Journal of molecular cell biology 2024 Oct 21;16(5)
Journal of molecular cell biology 2024 Oct 21;16(5)
m(6)A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells.
Kang Z, Li R, Liu C, Dong X, Hu Y, Xu L, Liu X, Xiang Y, Gao L, Si W, Wang L, Li Q, Zhang L, Wang H, Yang X, Liu J
Cell 2024 Oct 17;187(21):6035-6054.e27
Cell 2024 Oct 17;187(21):6035-6054.e27
A comprehensive analysis of CEBPA on prognosis and function in uterine corpus endometrial carcinoma.
Wang J, Huang W, Chai S, Gan J, Zeng Y, Long P, Pang L
Scientific reports 2024 Oct 10;14(1):23773
Scientific reports 2024 Oct 10;14(1):23773
Prognostic Value and Immune Signatures of Anoikis-related Genes in Breast Cancer.
Wu Q, Luo Y, Lin N, Zheng S, Xie X
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Oct 1;47(8):328-341
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Oct 1;47(8):328-341
Identification of NET formation and the renoprotective effect of degraded NETs in lupus nephritis.
Jin Y, Wang Y, Ma X, Li H, Zhang M
American journal of physiology. Renal physiology 2024 Oct 1;327(4):F637-F654
American journal of physiology. Renal physiology 2024 Oct 1;327(4):F637-F654
TNF-alpha promotes cilia elongation via mixed lineage kinases signaling in mouse fibroblasts and human RPE-1 cells.
Kumari A, Caliz AD, Yoo HJ, Kant S, Vertii A
Cytoskeleton (Hoboken, N.J.) 2024 Nov;81(11):639-647
Cytoskeleton (Hoboken, N.J.) 2024 Nov;81(11):639-647
Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke.
Du B, Deng Z, Chen K, Yang Z, Wei J, Zhou L, Meng J, Cheng Y, Tian X, Tuo QZ, Lei P
Genes & diseases 2024 Nov;11(6):101262
Genes & diseases 2024 Nov;11(6):101262
SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer.
Zhang Z, Tang Y, Wang Y, Xu J, Yang X, Liu M, Mazzone M, Niu N, Sun Y, Tang Y, Xue J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2402244
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2402244
POLQ knockdown inhibits proliferation, migration, and invasion by inducing cell cycle arrest in colorectal cancer.
Yao Q, Gao S, Sun Q, Liuhua Wang, Ren J, Wang D
Discover oncology 2024 Nov 9;15(1):633
Discover oncology 2024 Nov 9;15(1):633
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.
Lv D, Dixit D, Cruz AF, Kim LJY, Duan L, Xu X, Wu Q, Zhong C, Lu C, Gersey ZC, Gimple RC, Xie Q, Yang K, Liu X, Fang X, Wu X, Kidwell RL, Wang X, Bao S, He HH, Locasale JW, Agnihotri S, Rich JN
Cell metabolism 2024 Nov 5;36(11):2419-2436.e8
Cell metabolism 2024 Nov 5;36(11):2419-2436.e8
KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells.
Zhang Z, Yang D, Yan X, Qiu Q, Guo J, Qiu L
Cellular & molecular biology letters 2024 Nov 27;29(1):145
Cellular & molecular biology letters 2024 Nov 27;29(1):145
Rab11-Rab8 cascade dynamics in primary cilia and membrane tubules.
Saha I, Insinna C, Westlake CJ
Cell reports 2024 Nov 26;43(11):114955
Cell reports 2024 Nov 26;43(11):114955
Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage.
Chiang YF, Chen YT, Huang KC, Hung WL, Chung CP, Shieh TM, Huang YJ, Ali M, Hsia SM
Antioxidants (Basel, Switzerland) 2024 Nov 23;13(12)
Antioxidants (Basel, Switzerland) 2024 Nov 23;13(12)
The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.
Shimohama S, Fujioka R, Mihira N, Sekiguchi M, Sartori L, Joho D, Saito T, Saido TC, Nakahara J, Hino T, Hoshino A, Sasaguri H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2024 Nov 20;44(47)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2024 Nov 20;44(47)
LncRNA GTL2 regulates myoblast proliferation and differentiation via the PKA-CREB pathway in Duolang sheep.
Chen Q, Bao JJ, Zhang HC, Huang C, Zhao Q, Pu YB, Jiang L, Hosseiny A, Ibrahim M, Hussain T, He XH, Ma YH, Zhao QJ
Zoological research 2024 Nov 18;45(6):1261-1275
Zoological research 2024 Nov 18;45(6):1261-1275
In-vitro evidence indicating that IL-10 causes aging-related hypoalbuminemia via JAK1/STAT3 and CEBP-β.
Singh B, Kumari S, Kureel AK, Saini S, Prakash S, Shah A, Chaturvedi CP, Singh K, Rai AK
Experimental cell research 2024 Nov 1;443(1):114327
Experimental cell research 2024 Nov 1;443(1):114327
Endosomal actin branching, fission, and receptor recycling require FCHSD2 recruitment by MICAL-L1.
Frisby D, Murakonda AB, Ashraf B, Dhawan K, Almeida-Souza L, Naslavsky N, Caplan S
Molecular biology of the cell 2024 Nov 1;35(11):ar144
Molecular biology of the cell 2024 Nov 1;35(11):ar144
Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program.
Wu A, Zhang Y, Bock F, Arroyo JP, Delpire E, Zhang MZ, Harris RC, Terker AS
American journal of physiology. Renal physiology 2024 Nov 1;327(5):F899-F909
American journal of physiology. Renal physiology 2024 Nov 1;327(5):F899-F909
TET3-overexpressing macrophages promote endometriosis.
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael GG, Li D, Taylor HS, Huang Y
The Journal of clinical investigation 2024 Nov 1;134(21)
The Journal of clinical investigation 2024 Nov 1;134(21)
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
Liu J, Gao L, Zhou N, Jiang Z, Che S, Deng Y, Zang N, Ren L, Xie X, Xie J, Liu E
Virology 2024 May;593:110018
Virology 2024 May;593:110018
LINC01572 promotes triple-negative breast cancer progression through EIF4A3-mediated β-catenin mRNA nuclear exportation.
Zheng B, Zhou B, Ye D, Wang Y, Zheng W, Wang X, Liu D, Qian F, Zhou X, Yan T, Li Y, Fang L
Environmental toxicology 2024 May;39(5):3026-3039
Environmental toxicology 2024 May;39(5):3026-3039
Inhibition of influenza A virus and SARS-CoV-2 infection or co-infection by griffithsin and griffithsin-based bivalent entry inhibitor.
Cao N, Cai Y, Huang X, Jiang H, Huang Z, Xing L, Lu L, Jiang S, Xu W
mBio 2024 May 8;15(5):e0074124
mBio 2024 May 8;15(5):e0074124
Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology.
Madasu C, Liao Z, Parks SE, Sharma KL, Bohren KM, Ye Q, Li F, Palaniappan M, Tan Z, Yuan F, Creighton CJ, Tang S, Masand RP, Guan X, Young DW, Monsivais D, Matzuk MM
Proceedings of the National Academy of Sciences of the United States of America 2024 May 7;121(19):e2322934121
Proceedings of the National Academy of Sciences of the United States of America 2024 May 7;121(19):e2322934121
A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K/AKT/mTOR signaling pathway.
Fu J, Liang P, Zheng Y, Xu C, Xiong F, Yang F
Gene 2024 May 30;909:148312
Gene 2024 May 30;909:148312
Podocyte-Specific Deletion of MCP-1 Fails to Protect against Angiotensin II- or Adriamycin-Induced Glomerular Disease.
Bondi CD, Hartman HL, Rush BM, Tan RJ
International journal of molecular sciences 2024 May 3;25(9)
International journal of molecular sciences 2024 May 3;25(9)
Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation.
Wang S, Li W, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM
bioRxiv : the preprint server for biology 2024 May 3;
bioRxiv : the preprint server for biology 2024 May 3;
Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1.
Zhou X, Zhang K, Wang C, Teng Y, Yu P, Cai W, Gao W, Li M, Ding Y, Sun P, Chen F, Wang Y, Ma J, Maeshige N, Ma X, Li Q, Liang X, Zhang Y, Su D
Cancer letters 2024 May 28;590:216868
Cancer letters 2024 May 28;590:216868
Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel Disease.
Yu Y, Yang D, Lin B, Zhu L, Li C, Li X
ACS nano 2024 May 28;18(21):13583-13598
ACS nano 2024 May 28;18(21):13583-13598
In-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level.
Qin S, Zhang Y, Shi M, Miao D, Lu J, Wen L, Bai Y
Nature communications 2024 May 23;15(1):4387
Nature communications 2024 May 23;15(1):4387
Effects of chronic Cr and Ni co-exposure on liver inflammation and autophagy in mice by regulating the TLR4/mTOR pathway.
Cao X, Zheng S, Zeng Y, Shi Y, Du J, Huang C, Shen Y, Liu P, Guo X, Gao X
The Science of the total environment 2024 May 20;926:171921
The Science of the total environment 2024 May 20;926:171921
Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury.
Qian Z, Li R, Zhao T, Xie K, Li P, Li G, Shen N, Gong J, Hong X, Yang L, Li H
Cellular & molecular biology letters 2024 May 16;29(1):75
Cellular & molecular biology letters 2024 May 16;29(1):75
PLA2G12A protects against diet-induced obesity and insulin resistance by enhancing energy expenditure and clearance of circulating triglycerides.
Wu M, Wang Q, Li H, Tao J, Wang Z, Zhang S, Chen L, Li P, Chen L, Qu L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23643
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23643
Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency.
Zhen X, Betti MJ, Kars ME, Patterson A, Medina-Torres EA, Scheffler Mendoza SC, Herrera Sánchez DA, Lopez-Herrera G, Svyryd Y, Mutchinick OM, Gamazon E, Rathmell JC, Itan Y, Markle J, O'Farrill Romanillos P, Lugo-Reyes SO, Martinez-Barricarte R
medRxiv : the preprint server for health sciences 2024 May 14;
medRxiv : the preprint server for health sciences 2024 May 14;
Differential roles of putative arginine fingers of AAA(+) ATPases Rvb1 and Rvb2.
Warnock JL, Ball JA, Najmi SM, Henes M, Vazquez A, Koshnevis S, Wieden HJ, Conn GL, Ghalei H
bioRxiv : the preprint server for biology 2024 May 13;
bioRxiv : the preprint server for biology 2024 May 13;
Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart.
Lv Q, Li D, Zhao L, Yu P, Tao Y, Zhu Q, Wang Y, Wang M, Fu G, Shang M, Zhang W
Science advances 2024 May 10;10(19):eadl3549
Science advances 2024 May 10;10(19):eadl3549
Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion.
Yoshida K, Htike K, Eguchi T, Kawai H, Eain HS, Tran MT, Sogawa C, Umemori K, Ogawa T, Kanemoto H, Ono K, Nagatsuka H, Sasaki A, Ibaragi S, Okamoto K
Journal of oral biosciences 2024 Mar;66(1):205-216
Journal of oral biosciences 2024 Mar;66(1):205-216
Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice.
Yang H, Chen J, Liu S, Xue Y, Li Z, Wang T, Jiao L, An Q, Liu B, Wang J, Zhao H
Arteriosclerosis, thrombosis, and vascular biology 2024 Mar;44(3):e99-e115
Arteriosclerosis, thrombosis, and vascular biology 2024 Mar;44(3):e99-e115
Chemical Proteomics Reveals N(ε)-Fatty-Acylation of Septins by Rho Inactivation Domain (RID) of the Vibrio MARTX Toxin to Alter Septin Localization and Organization.
Xu Y, Ding K, Peng T
Molecular & cellular proteomics : MCP 2024 Mar;23(3):100730
Molecular & cellular proteomics : MCP 2024 Mar;23(3):100730
Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity.
Liu G, Ma N, Cheng K, Feng Q, Ma X, Yue Y, Li Y, Zhang T, Gao X, Liang J, Zhang L, Wang X, Ren Z, Fu YX, Zhao X, Nie G
Nature nanotechnology 2024 Mar;19(3):387-398
Nature nanotechnology 2024 Mar;19(3):387-398
CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.
Kent K, Nozawa K, Sutton C, Daniel F, Ikawa M, Garcia TX, Matzuk MM
Andrology 2024 Mar;12(3):682-697
Andrology 2024 Mar;12(3):682-697
Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids.
Yan J, Xiao L, Feng D, Chen B, Yang T, Tong B, Luo R, Wang Y, Chen J
Genes & diseases 2024 Mar;11(2):1066-1081
Genes & diseases 2024 Mar;11(2):1066-1081
Mitotic Spindle Positioning (MISP) Facilitates Colorectal Cancer Progression by Forming a Complex with Opa Interacting Protein 5 (OIP5) and Activating the JAK2-STAT3 Signaling Pathway.
Hiura K, Watanabe M, Hirose N, Nakano K, Okamura T, Sasaki H, Sasaki N
International journal of molecular sciences 2024 Mar 6;25(5)
International journal of molecular sciences 2024 Mar 6;25(5)
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y
The Journal of cell biology 2024 Mar 4;223(3)
The Journal of cell biology 2024 Mar 4;223(3)
Large-scale RNA-seq mining reveals ciclopirox triggers TDP-43 cryptic exons.
Sinha IR, Sandal PS, Burns GD, Mallika AP, Irwin KE, Cruz ALF, Wang V, Rodríguez JL, Wong PC, Ling JP
bioRxiv : the preprint server for biology 2024 Mar 30;
bioRxiv : the preprint server for biology 2024 Mar 30;
Roseburia intestinalis sensitizes colorectal cancer to radiotherapy through the butyrate/OR51E1/RALB axis.
Dong J, Wang B, Xiao Y, Liu J, Wang Q, Xiao H, Jin Y, Liu Z, Chen Z, Li Y, Fan S, Li Y, Cui M
Cell reports 2024 Mar 26;43(3):113846
Cell reports 2024 Mar 26;43(3):113846
Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA.
Brewer A, Sathe G, Pflug BE, Clarke RG, Macartney TJ, Sapkota GP
iScience 2024 Mar 15;27(3):109302
iScience 2024 Mar 15;27(3):109302
Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer.
Zhao A, Yang J, Ran R, Zhao S, Cui Y, Hu F, Zhou Y
Translational oncology 2024 Jun;44:101960
Translational oncology 2024 Jun;44:101960
The cGAS-Ku80 complex regulates the balance between two end joining subpathways.
Zhang H, Jiang L, Du X, Qian Z, Wu G, Jiang Y, Mao Z
Cell death and differentiation 2024 Jun;31(6):792-803
Cell death and differentiation 2024 Jun;31(6):792-803
miR-31-5p suppresses myocardial hypertrophy by targeting Nfatc2ip.
Zhao L, Qian X, Ren Z, Wang A
Journal of cellular and molecular medicine 2024 Jun;28(12):e18413
Journal of cellular and molecular medicine 2024 Jun;28(12):e18413
Targeting leucine-rich PPR motif-containing protein/LRPPRC by 5,7,4'-trimethoxyflavone suppresses esophageal squamous cell carcinoma progression.
Liu H, Zhou Y, Fredimoses M, Niu P, Ge Y, Wu R, Liu T, Li P, Shi Y, Shi Y, Liu K, Dong Z
International journal of biological macromolecules 2024 Jun;269(Pt 1):131966
International journal of biological macromolecules 2024 Jun;269(Pt 1):131966
Idebenone ameliorates statin-induced myotoxicity in atherosclerotic ApoE-/- mice by reducing oxidative stress and improving mitochondrial function.
Yu W, Wu W, Zhao D, Zhang R, Shao K, Liu H, Yan C, Lin P
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167157
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167157
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.
Wang H, Yuan S, Zheng Q, Zhang S, Zhang Q, Ji S, Wang W, Cao Y, Guo Y, Yang X, Geng H, Yang F, Xi S, Jin G, Zhang J, Gao Q, Bernards R, Qin W, Wang C
Gastroenterology 2024 Jun;166(6):1130-1144.e8
Gastroenterology 2024 Jun;166(6):1130-1144.e8
Chemical screen in zebrafish lateral line identified compounds that ameliorate neomycin-induced ototoxicity by inhibiting ferroptosis pathway.
Fan Y, Zhang Y, Qin D, Shu X
Cell & bioscience 2024 Jun 5;14(1):71
Cell & bioscience 2024 Jun 5;14(1):71
Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periosti.
Xie W, Gan J, Zhou X, Tian H, Pan X, Liu W, Li X, Du J, Xu A, Zheng M, Wu F, Li Y, Lin Z
Cell metabolism 2024 Jun 4;36(6):1269-1286.e9
Cell metabolism 2024 Jun 4;36(6):1269-1286.e9
An easy-to-perform method for microvessel isolation and primary brain endothelial cell culture to study Alzheimer's disease.
Chen Y, Huang X, Chen H, Yi C
Heliyon 2024 Jun 30;10(12):e33077
Heliyon 2024 Jun 30;10(12):e33077
Endosomal actin branching, fission and receptor recycling require FCHSD2 recruitment by MICAL-L1.
Frisby D, Murakonda AB, Ashraf B, Dhawan K, Almeida-Souza L, Naslavsky N, Caplan S
bioRxiv : the preprint server for biology 2024 Jun 29;
bioRxiv : the preprint server for biology 2024 Jun 29;
FLT3-selective PROTAC: Enhanced safety and increased synergy with Venetoclax in FLT3-ITD mutated acute myeloid leukemia.
Tan Y, Xin L, Wang Q, Xu R, Tong X, Chen G, Ma L, Yang F, Jiang H, Zhang N, Wu J, Li X, Guo X, Wang C, Zhou H, Zhou F
Cancer letters 2024 Jun 28;592:216933
Cancer letters 2024 Jun 28;592:216933
TFAP2A downregulation mediates tumor-suppressive effect of miR-8072 in triple-negative breast cancer via inhibiting SNAI1 transcription.
Fang Y, Wang Y, Ma H, Guo Y, Xu R, Chen X, Chen X, Lv Y, Li P, Gao Y
Breast cancer research : BCR 2024 Jun 18;26(1):103
Breast cancer research : BCR 2024 Jun 18;26(1):103
Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite.
Li Y, Huang M, Wang M, Wang Y, Deng P, Li C, Huang J, Chen H, Wei Z, Ouyang Q, Zhao J, Lu Y, Su S
Cancer cell 2024 Jun 10;42(6):985-1002.e18
Cancer cell 2024 Jun 10;42(6):985-1002.e18
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer.
Bharti R, Dey G, Khan D, Myers A, Huffman OG, Saygin C, Braley C, Richards E, Sangwan N, Willard B, Lathia JD, Fox PL, Lin F, Jha BK, Brown JM, Yu JS, Dwidar M, Joehlin-Price A, Vargas R, Michener CM, Longworth MS, Reizes O
Molecular cancer 2024 Jun 10;23(1):121
Molecular cancer 2024 Jun 10;23(1):121
Downregulated CDK10 promotes cancer progression and radioresistance in lung cancer through activating the JNK/c-Jun signaling pathway.
Hong C, Meng Y, Qiu A, Zhang H, Yang L, Hong Y, Huang Y
BMB reports 2024 Jul;57(7):336-341
BMB reports 2024 Jul;57(7):336-341
Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain.
Lin L, Deng J, Peng J, Cui J, Wang L, Zhang M, Gao J, Li F, Shi Y, Lv M
The FEBS journal 2024 Jul;291(13):2792-2810
The FEBS journal 2024 Jul;291(13):2792-2810
A novel FAM83G variant from palmoplantar keratoderma patient disrupts WNT signalling via loss of FAM83G-CK1α interaction.
Glennie L, Solà MC, Xunclà M, Español GA, Garcia-Arumí E, Tizzano EF, Wood NT, Macartney TJ, Lasa-Aranzasti A, Sapkota GP
Open biology 2024 Jul;14(7):240075
Open biology 2024 Jul;14(7):240075
Engineering an energy-dissipating hybrid tissue in vivo for obesity treatment.
Wang L, Sun Y, Yang L, Wang S, Liu C, Wang Y, Niu Y, Huang Z, Zhang J, Wang C, Dong L
Cell reports 2024 Jul 23;43(7):114425
Cell reports 2024 Jul 23;43(7):114425
miR-193b-3p and miR-346 Exert Antihypertensive Effects in the Rostral Ventrolateral Medulla.
Zhang S, Wang X, Dai T, Tong L, Chen G, Wang L, Ren Z, Liu H, Du D
Journal of the American Heart Association 2024 Jul 2;13(13):e034965
Journal of the American Heart Association 2024 Jul 2;13(13):e034965
Downregulation of Splicing Factor PTBP1 Curtails FBXO5 Expression to Promote Cellular Senescence in Lung Adenocarcinoma.
Li H, Sun X, Lv Y, Wei G, Ni T, Qin W, Jin H, Jia Q
Current issues in molecular biology 2024 Jul 19;46(7):7730-7744
Current issues in molecular biology 2024 Jul 19;46(7):7730-7744
Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation.
Chatterjee BK, Alam M, Chakravorty A, Lacy SM, Rech J, Brooks CL 3rd, Arvan PD, Truttmann MC
bioRxiv : the preprint server for biology 2024 Jul 16;
bioRxiv : the preprint server for biology 2024 Jul 16;
Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency.
Zhen X, Betti M, Kars ME, Patterson A, Medina-Torres EA, Scheffler Mendoza SC, Herrera Sánchez DA, Lopez-Herrera G, Svyryd Y, Mutchinick O, Gamazon E, Rathmell J, Itan Y, Markle J, O'Farrill Romanillos P, Lugo-Reyes SO, Martinez-Barricarte R
Research square 2024 Jul 11;
Research square 2024 Jul 11;
Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides.
Huang D, Zhu X, Ye S, Zhang J, Liao J, Zhang N, Zeng X, Wang J, Yang B, Zhang Y, Lao L, Chen J, Xin M, Nie Y, Saw PE, Su S, Song E
Nature 2024 Jan;625(7995):593-602
Nature 2024 Jan;625(7995):593-602
CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
Shen M, Wu Y, Li L, Zhang L, Liu G, Wang R
Journal of diabetes 2024 Jan;16(1):e13471
Journal of diabetes 2024 Jan;16(1):e13471
SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair.
Huang Y, Tang M, Hu Z, Cai B, Chen G, Jiang L, Xia Y, Guan P, Li X, Mao Z, Wan X, Lu W
Oncogenesis 2024 Jan 8;13(1):3
Oncogenesis 2024 Jan 8;13(1):3
Rapid and comprehensive metabolites identification of 5-demethylnobiletin in rats using UPLC/Triple-TOF-MS/MS based on multiple mass defect filter and their neuroprotection against ferroptosis.
Yuan S, Gao P, Wu S, Liang X, Xiao Y, Tu P, Jiang Y
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115842
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115842
Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility†.
Daniel-Carlier N, Castille J, Passet B, Vilotte M, Le Danvic C, Jaffrezic F, Beauvallet C, Péchoux C, Capitan A, Vilotte JL
Biology of reproduction 2024 Jan 13;110(1):78-89
Biology of reproduction 2024 Jan 13;110(1):78-89
Adventitial delivery of miR-145 to treat intimal hyperplasia post vascular injuries through injectable and in-situ self-assembling peptide hydrogels.
Zhao J, Wu S, Zhang M, Hong X, Zhao M, Xu S, Ji J, Ren K, Fu G, Fu J
Acta biomaterialia 2024 Jan 1;173:247-260
Acta biomaterialia 2024 Jan 1;173:247-260
Hypomethylating agent decitabine sensitizes diffuse large B-cell lymphoma to venetoclax.
Zhu F, Crombie JL, Ni W, Hoang NM, Garg S, Hackett L, Chong SJF, Collins MC, Rui L, Griffin J, Davids MS
Haematologica 2024 Jan 1;109(1):186-199
Haematologica 2024 Jan 1;109(1):186-199
Ceramide enhanced the hepatic glucagon response through regulation of CREB activity.
Wang J, Wang D, Lu S, Hu Y, Ge Y, Qin X, Mo Y, Kan J, Li D, Zhang R, Liu Y, Zhang WS
Clinical nutrition (Edinburgh, Scotland) 2024 Feb;43(2):366-378
Clinical nutrition (Edinburgh, Scotland) 2024 Feb;43(2):366-378
Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice.
Tian XJ, Yin ZJ, Li ZJ, Wang ZZ, Xing Z, Liu CY, Wang LT, Wang CM, Zhang JF, Dong L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2305913
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2305913
UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.
Li Y, Jiang M, Aye L, Luo L, Zhang Y, Xu F, Wei Y, Peng D, He X, Gu J, Yu X, Li G, Ge D, Lu C
Nature communications 2024 Feb 8;15(1):1200
Nature communications 2024 Feb 8;15(1):1200
Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape.
Yang K, Chen G, Yu F, Fang X, Zhang J, Zhang Z, Shi Y, Zhang L
Communications biology 2024 Feb 7;7(1):158
Communications biology 2024 Feb 7;7(1):158
Bleomycin reduces Vairimorpha (Nosema) ceranae infection in honey bees with some evident host toxicity.
Parrella P, Elikan AB, Kogan HV, Wague F, Marshalleck CA, Snow JW
Microbiology spectrum 2024 Feb 6;12(2):e0334923
Microbiology spectrum 2024 Feb 6;12(2):e0334923
IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1.
Chen Y, Huang L, Gan RH, Yuan S, Lan T, Zheng D, Lu YG
Cell death discovery 2024 Feb 6;10(1):65
Cell death discovery 2024 Feb 6;10(1):65
Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells.
Cao X, Xue L, Yu X, Yan Y, Lu J, Luo X, Wang H, Wang J
Aging 2024 Feb 29;16(5):4609-4630
Aging 2024 Feb 29;16(5):4609-4630
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib.
Zhang B, Chen Y, Chen X, Ren Z, Xiang H, Mao L, Zhu G
Cancer cell international 2024 Feb 24;24(1):83
Cancer cell international 2024 Feb 24;24(1):83
The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway.
Suman I, Šimić L, Čanadi Jurešić G, Buljević S, Klepac D, Domitrović R
Cell death discovery 2024 Feb 24;10(1):98
Cell death discovery 2024 Feb 24;10(1):98
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling.
Jia J, Zhu L, Yue X, Tang S, Jing S, Tan C, Du Y, Gao J, Lee I, Qian Y
Cell communication and signaling : CCS 2024 Feb 20;22(1):140
Cell communication and signaling : CCS 2024 Feb 20;22(1):140
Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis.
Dunn TN, Cope DI, Tang S, Sirupangi T, Parks SE, Liao Z, Yuan F, Creighton CJ, Masand RP, Alpuing Radilla L, Guan X, Detti L, Monsivais D, Matzuk MM
Endocrinology 2024 Feb 20;165(4)
Endocrinology 2024 Feb 20;165(4)
Characterization of immunogenic cell death regulators predicts survival and immunotherapy response in lung adenocarcinoma.
Zhou D, Cui Y, Zhu M, Lin Y, Guo J, Li Y, Zhang J, Wu Z, Guo J, Chen Y, Liang W, Lin W, Lei K, Zhao T, You Q
Life sciences 2024 Feb 1;338:122396
Life sciences 2024 Feb 1;338:122396
SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay.
Hou B, Hu Y, Zhu Y, Wang X, Li W, Tang J, Jia X, Wang J, Cong Y, Quan M, Yang H, Zheng H, Bao Y, Chen XL, Wang HR, Xu B, Gascoigne NRJ, Fu G
Journal of immunology (Baltimore, Md. : 1950) 2024 Feb 1;212(3):397-409
Journal of immunology (Baltimore, Md. : 1950) 2024 Feb 1;212(3):397-409
Regulatory roles of NAMPT and NAD(+) metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment.
Chiang YF, Huang KC, Huang TC, Chen HY, Ali M, Al-Hendy A, Huang PS, Hsia SM
Redox biology 2024 Dec;78:103411
Redox biology 2024 Dec;78:103411
Herbal medicine Ninjinyoeito inhibits RANKL-induced osteoclast differentiation and bone resorption activity by regulating NF-κB and MAPK pathway.
Htike K, Yoshida K, Eguchi T, Takebe K, Li X, Qu Y, Sakai E, Tsukuba T, Okamoto K
Journal of oral biosciences 2024 Dec;66(4):49-57
Journal of oral biosciences 2024 Dec;66(4):49-57
Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy.
Zhai J, Wang C, Jin L, Liu F, Xiao Y, Gu H, Liu M, Chen Y
Molecular neurobiology 2024 Dec;61(12):9794-9809
Molecular neurobiology 2024 Dec;61(12):9794-9809
Hsa_circRNA_000166 accelerates breast cancer progression via the regulation of the miR-326/ELK1 and miR-330-5p/ELK1 axes.
Wang MH, Liu ZH, Zhang HX, Liu HC, Ma LH
Annals of medicine 2024 Dec;56(1):2424515
Annals of medicine 2024 Dec;56(1):2424515
KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.
Wu T, Cheng AY, Zhang Y, Xu J, Wu J, Wen L, Li X, Liu B, Dou X, Wang P, Zhang L, Fei J, Li J, Ouyang Z, He C
Nature biotechnology 2024 Dec;42(12):1909-1920
Nature biotechnology 2024 Dec;42(12):1909-1920
Knockdown of nicotinamide N-methyltransferase ameliorates renal fibrosis caused by ischemia-reperfusion injury and remodels sphingosine metabolism.
Xu W, Hou L
Clinical and experimental nephrology 2024 Dec;28(12):1241-1253
Clinical and experimental nephrology 2024 Dec;28(12):1241-1253
Carrier frequency and incidence estimation of deficiency of adenosine deaminase 2 in the Chinese population based on massive exome sequencing data.
Yan L, Sun X, Lou B, Zhang Y, Zhuang D, Jia J, Zhang L, He Y, Xu L, Wu S, Zhou Q, Chen C, Yu X, Li H
Clinical immunology (Orlando, Fla.) 2024 Dec;269:110394
Clinical immunology (Orlando, Fla.) 2024 Dec;269:110394
Design, synthesis, and biological evaluation of novel 5,7,4'-trimethoxyflavone sulfonamide-based derivatives as highly potent inhibitors of LRPPRC/STAT3/CDK1.
Wu R, Li P, Hao B, Fredimoses M, Ge Y, Zhou Y, Tang L, Li Y, Liu H, Janson V, Hu Y, Liu H
Bioorganic chemistry 2024 Dec;153:107878
Bioorganic chemistry 2024 Dec;153:107878
Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway.
Li W, Zhong Y, Lin Z, Deng Z, Long D, Li M, Li C, Mao G, Kang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156052
A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicity.
Li Y, Zhang X, Tai W, Zhuang X, Shi H, Liao S, Yu X, Mei R, Chen X, Huang Y, Liu Y, Liu J, Liu Y, Zhu Y, Wang P, Tian M, Yu G, Li L, Cheng G
EBioMedicine 2024 Dec;110:105437
EBioMedicine 2024 Dec;110:105437
Suppression of microtubule acetylation mediates the anti-leukemic effect of CDK9 inhibition.
Xie X, Zhang B, Li D, Gao J, Li J, Liu C, Dan Y, Xu P, Yan L, Huang X, Zhang R, Yao Y, Huang W, Nie J, Wang X, Jiao B, Ren R, Liu P
Cancer cell international 2024 Dec 5;24(1):396
Cancer cell international 2024 Dec 5;24(1):396
Molecular and Clinical Characterization of a Founder Mutation Causing G6PC3 Deficiency.
Zhen X, Betti MJ, Kars ME, Patterson AR, Medina-Torres EA, Scheffler Mendoza SC, Herrera Sánchez DA, Lopez-Herrera G, Svyryd Y, Mutchinick OM, Gamazon ER, Rathmell JC, Itan Y, Markle J, O'Farrill Romanillos P, Lugo-Reyes SO, Martinez-Barricarte R
Journal of clinical immunology 2024 Dec 4;45(1):53
Journal of clinical immunology 2024 Dec 4;45(1):53
Activation of β3-adrenergic receptor by mirabegron prevents aortic dissection/aneurysm by promoting lymphangiogenesis in perivascular adipose tissue.
Zhang ZB, Cheng YW, Xu L, Li JQ, Pan X, Zhu M, Chen XH, Sun AJ, Lin JR, Gao PJ
Cardiovascular research 2024 Dec 31;120(17):2307-2319
Cardiovascular research 2024 Dec 31;120(17):2307-2319
S100A8 knockdown activates the PI3K/AKT signaling pathway to inhibit microglial autophagy and improve cognitive impairment mediated by chronic sleep deprivation.
Xiong Y, Liang W, Wang X, Zhu H, Yi P, Wei G, Liu H, Lin Y, Zhang L, Ying J, Hua F
International immunopharmacology 2024 Dec 25;143(Pt 2):113375
International immunopharmacology 2024 Dec 25;143(Pt 2):113375
Scalp acupuncture alleviates remote hippocampal damage in MCAO rats by inhibiting neuroinflammation: A TMT-based proteomics analysis.
Liu H, Huang W, Ding Q, Huang Y, Lai Z, Liu Z, Li S, Peng X, Wu Z, Deng L, Huang Y, Chen J
Neuroscience 2024 Dec 17;563:117-128
Neuroscience 2024 Dec 17;563:117-128
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain.
Chan YH, Liu Z, Bastard P, Khobrekar N, Hutchison KM, Yamazaki Y, Fan Q, Matuozzo D, Harschnitz O, Kerrouche N, Nakajima K, Amin P, Yatim A, Rinchai D, Chen J, Zhang P, Ciceri G, Chen J, Dobbs K, Belkaya S, Lee D, Gervais A, Aydın K, Kartal A, Hasek ML, Zhao S, Reino EG, Lee YS, Seeleuthner Y, Chaldebas M, Bailey R, Vanhulle C, Lorenzo L, Boucherit S, Rozenberg F, Marr N, Mogensen TH, Aubart M, Cobat A, Dulac O, Emiroglu M, Paludan SR, Abel L, Notarangelo L, Longnecker R, Smith G, Studer L, Casanova JL, Zhang SY
Nature 2024 Aug;632(8024):390-400
Nature 2024 Aug;632(8024):390-400
Genetic risk factors for COVID-19 and influenza are largely distinct.
Kosmicki JA, Marcketta A, Sharma D, Di Gioia SA, Batista S, Yang XM, Tzoneva G, Martinez H, Sidore C, Kessler MD, Horowitz JE, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Leader JB, Park DS, Lanche R, Maxwell E, Knight SC, Bai X, Guturu H, Baltzell A, Girshick AR, McCurdy SR, Partha R, Mansfield AJ, Turissini DA, Zhang M, Mbatchou J, Watanabe K, Verma A, Sirugo G, Colorado Center for Precision Medicine, Mayo Clinic Project Generation, Regeneron Genetics Center, University of California Los Angeles ATLAS Collaboration, Ritchie MD, Salerno WJ, Shuldiner AR, Rader DJ, Mirshahi T, Marchini J, Overton JD, Carey DJ, Habegger L, Reid JG, Economides A, Kyratsous C, Karalis K, Baum A, Cantor MN, Rand KA, Hong EL, Ball CA, Siminovitch K, Baras A, Abecasis GR, Ferreira MAR
Nature genetics 2024 Aug;56(8):1592-1596
Nature genetics 2024 Aug;56(8):1592-1596
Haspin mediates H3.3S31 phosphorylation downstream of Aurora B in mouse embryonic stem cells.
Li Y, Wu M, Liu Y, Sun L, Mu P, Ma B, Xie J
Protein science : a publication of the Protein Society 2024 Aug;33(8):e5126
Protein science : a publication of the Protein Society 2024 Aug;33(8):e5126
The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence.
Tang H, Yang J, Xu J, Zhang W, Geng A, Jiang Y, Mao Z
EMBO reports 2024 Aug;25(8):3263-3275
EMBO reports 2024 Aug;25(8):3263-3275
Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.
Ou N, Wang Y, Xu S, Luo J, Zhang C, Zhang Y, Shi X, Xiong M, Zhao L, Ji Z, Zhang Y, Zhao J, Bai H, Tian R, Li P, Zhi E, Huang Y, Chen W, Wang R, Jin Y, Wang D, Li Z, Chen H, Yao C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692
miR-181a expressed in the dorsal hippocampus regulates the reinstatement of cocaine CPP by targeting PRKAA1.
Zhu J, Hou Y, Li W, Wang X, Li F, Li N, Hu Y, Wang X, Ge SN
Behavioural brain research 2024 Aug 5;471:115097
Behavioural brain research 2024 Aug 5;471:115097
NADPH oxidase-dependent free radical generation and protein adduct formation in neutrophils.
Manoharan RR, Zachová K, Buzáš M, Pospíšil P, Křupka M, Prasad A
RSC advances 2024 Aug 5;14(34):24765-24780
RSC advances 2024 Aug 5;14(34):24765-24780
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
Tuomivaara ST, Teo CF, Jan YN, Wiita AP, Jan LY
Communications biology 2024 Aug 29;7(1):1060
Communications biology 2024 Aug 29;7(1):1060
Drug-induced senescence by aurora kinase inhibitors attenuates innate immune response of macrophages on gastric cancer organoids.
Yang R, Kwan W, Du Y, Yan R, Zang L, Li C, Zhu Z, Cheong IH, Kozlakidis Z, Yu Y
Cancer letters 2024 Aug 28;598:217106
Cancer letters 2024 Aug 28;598:217106
Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling.
Brewer A, Zhao JF, Fasimoye R, Shpiro N, Macartney TJ, Wood NT, Wightman M, Alessi DR, Sapkota GP
iScience 2024 Aug 16;27(8):110423
iScience 2024 Aug 16;27(8):110423
Paired organoids from primary gastric cancer and lymphatic metastasis are useful for personalized medicine.
Yang R, Qi Y, Kwan W, Du Y, Yan R, Zang L, Yao X, Li C, Zhu Z, Zhang X, Gao H, Cheong IH, Kozlakidis Z, Yu Y
Journal of translational medicine 2024 Aug 12;22(1):754
Journal of translational medicine 2024 Aug 12;22(1):754
Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage.
Gong K, Xue C, Feng Z, Pan R, Wang M, Chen S, Chen Y, Guan Y, Dai L, Zhang S, Jiang L, Li L, Wang B, Yin Z, Ma L, Iwakiri Y, Tang J, Liao C, Chen H, Duan Y
Nature communications 2024 Aug 10;15(1):6845
Nature communications 2024 Aug 10;15(1):6845
Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors.
Murray MA, Noronha KJ, Wang Y, Friedman AP, Paradkar S, Suh HW, Sundaram RK, Brenner C, Saltzman WM, Bindra RS
Molecular cancer therapeutics 2024 Aug 1;23(8):1176-1187
Molecular cancer therapeutics 2024 Aug 1;23(8):1176-1187
Macrocarpal B blocks the binding between the phospholipase A2 receptor and its antibodies.
Feng Z, Guo FS, Wang Q, Wang M, Zhao MH, Cui Z, Lei X
Bioorganic & medicinal chemistry 2024 Aug 1;110:117793
Bioorganic & medicinal chemistry 2024 Aug 1;110:117793
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.
Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett AM, Diano S, Huang Y
Diabetologia 2024 Apr;67(4):724-737
Diabetologia 2024 Apr;67(4):724-737
M2 macrophage-derived exosomes carry miR-142-3p to restore the differentiation balance of irradiated BMMSCs by targeting TGF-β1.
Huang C, Zhao L, Xiao Y, Tang Z, Jing L, Guo K, Tian L, Zong C
Molecular and cellular biochemistry 2024 Apr;479(4):993-1010
Molecular and cellular biochemistry 2024 Apr;479(4):993-1010
Coptisine inhibits neointimal hyperplasia through attenuating Pak1/Pak2 signaling in vascular smooth muscle cells without retardation of re-endothelialization.
Chen Y, Jiang X, Yuan Y, Chen Y, Wei S, Yu Y, Zhou Q, Yu Y, Wang J, Liu H, Hua X, Yang Z, Chen Z, Li Y, Wang Q, Chen J, Wang Y
Atherosclerosis 2024 Apr;391:117480
Atherosclerosis 2024 Apr;391:117480
Age-Related Gut Microbiota Transplantation Disrupts Myocardial Energy Homeostasis and Induces Oxidative Damage.
Xu H, Li O, Kim D, Yang F, Bao Z
The Journal of nutrition 2024 Apr;154(4):1189-1199
The Journal of nutrition 2024 Apr;154(4):1189-1199
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
Qian Z, Xia M, Zhao T, Li Y, Li G, Zhang Y, Li H, Yang L
Clinical and translational medicine 2024 Apr;14(4):e1661
Clinical and translational medicine 2024 Apr;14(4):e1661
N6-methyladenosine-modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis.
Li H, Tang Y, Ruan X, Zhang J, Liu H, Yu S, Chen H, Yang H, Zhang K, Chen K
Clinical and translational medicine 2024 Apr;14(4):e1658
Clinical and translational medicine 2024 Apr;14(4):e1658
Schisandrin A alleviates renal fibrosis by inhibiting PKCβ and oxidative stress.
Liu HL, Huang Z, Li QZ, Cao YZ, Wang HY, Alolgab RN, Deng XY, Zhang ZH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155372
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155372
Co-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis.
Wang Y, Peng Y, Zi G, Chen J, Peng B
Scientific reports 2024 Apr 6;14(1):8095
Scientific reports 2024 Apr 6;14(1):8095
PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis.
Zhang L, Nie F, Zhao J, Li S, Liu W, Guo H, Yang P
Journal of translational medicine 2024 Apr 30;22(1):407
Journal of translational medicine 2024 Apr 30;22(1):407
Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets.
Zhao D, Guo Y, Wei H, Jia X, Zhi Y, He G, Nie W, Huang L, Wang P, Laster KV, Liu Z, Wang J, Lee MH, Dong Z, Liu K
JCI insight 2024 Apr 23;9(10)
JCI insight 2024 Apr 23;9(10)
Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation.
Du R, Xiao N, Han L, Guo K, Li K, Chen Z, Zhang H, Zhou Z, Huang Y, Zhao X, Bian H
Scientific reports 2024 Apr 22;14(1):9167
Scientific reports 2024 Apr 22;14(1):9167
GDF9(His209GlnfsTer6/S428T) and GDF9(Q321X/S428T) bi-allelic variants caused female subfertility with defective follicle enlargement.
Duan Y, Cai B, Guo J, Wang C, Mai Q, Xu Y, Zeng Y, Shi Y, Wang B, Ding C, Chen M, Zhou C, Xu Y
Cell communication and signaling : CCS 2024 Apr 20;22(1):235
Cell communication and signaling : CCS 2024 Apr 20;22(1):235
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.
Yu L, Wan Q, Liu Q, Fan Y, Zhou Q, Skowronski AA, Wang S, Shao Z, Liao CY, Ding L, Kennedy BK, Zha S, Que J, LeDuc CA, Sun L, Wang L, Qiang L
Cell metabolism 2024 Apr 2;36(4):793-807.e5
Cell metabolism 2024 Apr 2;36(4):793-807.e5
The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression.
Nie F, Zhang J, Tian H, Zhao J, Gong P, Wang H, Wang S, Yang P, Yang C
Cell death & disease 2024 Apr 18;15(4):277
Cell death & disease 2024 Apr 18;15(4):277
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Wang M, Liu Y, Gui H, Ma G, Li B, Zhang Z, Yu G, Wu A, Xu X, Zhang D
European journal of pharmacology 2024 Apr 15;969:176303
European journal of pharmacology 2024 Apr 15;969:176303
Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease.
Huang X, Qi J, Su Y, Zhou Y, Wang Q, Huang T, Xue D, Zeng Y, Verkhratsky A, Zhou B, Chen H, Yi C
Cell death & disease 2024 Apr 12;15(4):258
Cell death & disease 2024 Apr 12;15(4):258
Ferrostatin-1 mitigates ionizing radiation-induced intestinal injuries by inhibiting apoptosis and ferroptosis: an in vitro and in vivo study.
Wang X, Li W, Dong Y, Zhang Y, Huo Q, Lu L, Zhang J, Zhao Y, Fan S, Dong H, Li D
International journal of radiation biology 2023;99(10):1607-1618
International journal of radiation biology 2023;99(10):1607-1618
Electric field promotes dermal fibroblast transdifferentiation through activation of RhoA/ROCK1 pathway.
Wang W, Huang W, Liu J, Zhang Z, Ji R, Wu C, Zhang J, Jiang X
International journal of medical sciences 2023;20(10):1326-1335
International journal of medical sciences 2023;20(10):1326-1335
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
Zhang L, Huang J, Dai L, Zhu G, Yang XL, He Z, Li YH, Yang H, Zhang CQ, Shen KF, Liang P
Frontiers in neurology 2023;14:1255097
Frontiers in neurology 2023;14:1255097
Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer.
Zhang B, Ren Z, Zhao J, Zhu Y, Huang B, Xiao C, Zhang Y, Deng J, Mao L, Tang L, Lan D, Gao L, Zhang H, Chen G, Luo OJ
Theranostics 2023;13(13):4449-4468
Theranostics 2023;13(13):4449-4468
Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis.
Zhang R, Chen S, Yang Z, Zhang N, Guo K, Lv K, Zhou Z, Gao M, Hu X, Su Y, He J, Wang F
Burns & trauma 2023;11:tkad038
Burns & trauma 2023;11:tkad038
Electroacupuncture alleviated depression-like behaviors in ventromedial prefrontal cortex of chronic unpredictable mild stress-induced rats: Increasing synaptic transmission and phosphorylating dopamine transporter.
Cai X, Wu M, Zhang Z, Liu H, Huang S, Song J, Ren S, Huang Y
CNS neuroscience & therapeutics 2023 Sep;29(9):2608-2620
CNS neuroscience & therapeutics 2023 Sep;29(9):2608-2620
Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
Hou H, Chen Y, Feng X, Xu G, Yan M
Molecular medicine reports 2023 Sep;28(3)
Molecular medicine reports 2023 Sep;28(3)
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Fang Z, Li Y, Wang J, Wang X, Huang L, Sun L, Deng Q
Biological trace element research 2023 Sep;201(9):4437-4446
Biological trace element research 2023 Sep;201(9):4437-4446
Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation.
Ji L, Song T, Ge C, Wu Q, Ma L, Chen X, Chen T, Chen Q, Chen Z, Chen W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115210
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115210
Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ.
Liu F, Li S, Chen P, Gu Y, Wang S, Wang L, Chen C, Wang R, Yuan Y
International immunopharmacology 2023 Sep;122:110550
International immunopharmacology 2023 Sep;122:110550
hESC-Derived Epicardial Cells Promote Repair of Infarcted Hearts in Mouse and Swine.
Luo XL, Jiang Y, Li Q, Yu XJ, Ma T, Cao H, Ke MX, Zhang P, Tan JL, Gong YS, Wang L, Gao L, Yang HT
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2300470
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2300470
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
Zhang F, Zhang B, Ding H, Li X, Wang X, Zhang X, Liu Q, Feng Q, Han M, Chen L, Qi L, Yang D, Li X, Zhu X, Zhao Q, Qiu J, Zhu Z, Tang H, Shen N, Wang H, Wei B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2207108
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2207108
Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss.
Zhou X, Jin L, Li Y, Wang Y, Li W, Shen X
BMC genomics 2023 Sep 27;24(1):577
BMC genomics 2023 Sep 27;24(1):577
Identification of VPS34-PI(3)P-FEN1-mediated DNA repair pathway as a potential drug target to overcome chemoresistance.
Zhang X, Dan S, Pan X, Li J, Wei Q, Huang L, Kang B, Chen C
Biochemical and biophysical research communications 2023 Sep 24;674:27-35
Biochemical and biophysical research communications 2023 Sep 24;674:27-35
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis.
Wang B, Liang Z, Tan T, Zhang M, Jiang Y, Shang Y, Gao X, Song S, Wang R, Chen H, Liu J, Li J, Ren Y, Liu P
eLife 2023 Sep 22;12
eLife 2023 Sep 22;12
A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease.
Homma K, Enoki Y, Uchida S, Taguchi K, Matsumoto K
FASEB bioAdvances 2023 Oct;5(10):377-394
FASEB bioAdvances 2023 Oct;5(10):377-394
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.
Yao Y, Cao Y, Xu Y, Chen G, Liu Y, Jiang H, Fan R, Qin W, Wang X, Chai H, Chen X, Qiu Z, Chen W
The Canadian journal of cardiology 2023 Oct;39(10):1449-1462
The Canadian journal of cardiology 2023 Oct;39(10):1449-1462
Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism.
Gan PXL, Liao W, Lim HF, Wong WSF
Pharmacological research 2023 Oct;196:106929
Pharmacological research 2023 Oct;196:106929
Evaluation of the radiosensitizing effect of MEK inhibitor KZ-001 on non-small cell lung cancer cells in vitro.
Huang G, Zhang W, Tian H
Asian biomedicine : research, reviews and news 2023 Oct;17(5):230-237
Asian biomedicine : research, reviews and news 2023 Oct;17(5):230-237
Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction proteins and the TRPA1 modulation.
Lai YH, Chiang YF, Huang KC, Chen HY, Ali M, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115334
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115334
Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.
Yang T, Shi X, Li S, Zhao Z, Wang J, Yu P, Li H, Wang R, Chen Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115314
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115314
Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response.
Rao A, Ni Z, Suresh D, Mohanty C, Wang AR, Lee DL, Nickel KP, Varambally SRJ, Lambert PF, Kendziorski C, Iyer G
bioRxiv : the preprint server for biology 2023 Oct 4;
bioRxiv : the preprint server for biology 2023 Oct 4;
Chimpanzee adenovirus-mediated multiple gene therapy for age-related macular degeneration.
Wei-Zhang S, Cui B, Xing M, Liu J, Guo Y, He K, Bai T, Dong X, Lei Y, Zhou W, Zhou H, Liu S, Wang X, Zhou D, Yan H
iScience 2023 Oct 20;26(10):107939
iScience 2023 Oct 20;26(10):107939
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein.
Bosnakovski D, Toso EA, Ener ET, Gearhart MD, Yin L, Lüttmann FF, Magli A, Shi K, Kim J, Aihara H, Kyba M
iScience 2023 Oct 20;26(10):107823
iScience 2023 Oct 20;26(10):107823
Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups.
Lobón-Iglesias MJ, Andrianteranagna M, Han ZY, Chauvin C, Masliah-Planchon J, Manriquez V, Tauziede-Espariat A, Turczynski S, Bouarich-Bourimi R, Frah M, Dufour C, Blauwblomme T, Cardoen L, Pierron G, Maillot L, Guillemot D, Reynaud S, Bourneix C, Pouponnot C, Surdez D, Bohec M, Baulande S, Delattre O, Piaggio E, Ayrault O, Waterfall JJ, Servant N, Beccaria K, Dangouloff-Ros V, Bourdeaut F
Nature communications 2023 Oct 20;14(1):6669
Nature communications 2023 Oct 20;14(1):6669
Lycorine promotes IDH1 acetylation to induce mitochondrial dynamics imbalance in colorectal cancer cells.
Zhuo FF, Li L, Liu TT, Liang XM, Yang Z, Zheng YZ, Luo QW, Lu JH, Liu D, Zeng KW, Tu PF
Cancer letters 2023 Oct 1;573:216364
Cancer letters 2023 Oct 1;573:216364
An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity.
Wu T, Liu C, Zou S, Lyu R, Yang B, Yan H, Zhao M, Tang W
Nature chemical biology 2023 Nov;19(11):1384-1393
Nature chemical biology 2023 Nov;19(11):1384-1393
Assigning functionality to cysteines by base editing of cancer dependency genes.
Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, Cravatt BF
Nature chemical biology 2023 Nov;19(11):1320-1330
Nature chemical biology 2023 Nov;19(11):1320-1330
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer.
Chen HY, Lin CE, Wu SC, Yang ZY, Chiang YF, Huang KC, Wang KL, Ali M, Shieh TM, Chang HY, Huang TC, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115533
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115533
Towards modular engineering of cell signalling: Topographically-textured microparticles induce osteogenesis via activation of canonical hedgehog signalling.
Ghuloum FI, Stevens LA, Johnson CA, Riobo-Del Galdo NA, Amer MH
Biomaterials advances 2023 Nov;154:213652
Biomaterials advances 2023 Nov;154:213652
Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8(+) T cells.
He W, Wang X, Chen M, Li C, Chen W, Pan L, Cui Y, Yu Z, Wu G, Yang Y, Xu M, Dong Z, Ma K, Wang J, He Z
Clinical and translational medicine 2023 Nov;13(11):e1465
Clinical and translational medicine 2023 Nov;13(11):e1465
RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts.
Kattan FG, Koukouraki P, Anagnostopoulos AK, Tsangaris GT, Doxakis E
Open biology 2023 Nov;13(11):230158
Open biology 2023 Nov;13(11):230158
Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti-Tumor Immunity.
Ma H, Fang W, Li Q, Wang Y, Hou SX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2305089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2305089
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase.
Yu T, Nie S, Bu L, Liu M, He J, Niu X, Feng H, Guo J, Tang B, Zhang Z, Ye K, Jiang H, Chen L, Zhang Z
JCI insight 2023 Nov 8;8(21)
JCI insight 2023 Nov 8;8(21)
ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria.
Zhou Q, Yang Y, Xu Z, Deng K, Zhang Z, Hao J, Li N, Wang Y, Wang Z, Chen H, Yang Y, Xiao F, Zhang X, Gao S, Li YP
EMBO reports 2023 Nov 6;24(11):e56614
EMBO reports 2023 Nov 6;24(11):e56614
Compound 5 alleviated acute kidney injury without affecting the antitumor effect after cisplatin treatment.
Guo Y, Li X, Yuan R, Ren J, Huang Y, Tian H
Biochemical and biophysical research communications 2023 Nov 5;680:177-183
Biochemical and biophysical research communications 2023 Nov 5;680:177-183
Aryl hydrocarbon receptor is a tumor promoter in MYCN-amplified neuroblastoma cells through suppression of differentiation.
Chaudhry KA, Jacobi JJ, Gillard BM, Karasik E, Martin JC, da Silva Fernandes T, Hurley E, Feltri ML, Attwood KM, Twist CJ, Smiraglia DJ, Long MD, Bianchi-Smiraglia A
iScience 2023 Nov 17;26(11):108303
iScience 2023 Nov 17;26(11):108303
KZ02 enhances the radiosensitivity of BRAF-mutated CRC in vitro and in vivo.
Guo Y, Li X, Yuan R, Ren J, Huang Y, Yu Y, Tian H
European journal of pharmacology 2023 Nov 15;959:176060
European journal of pharmacology 2023 Nov 15;959:176060
Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells.
Zhang Y, Xia M, Zhao T, Zhang Q, Li R, Yang L
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Nov 15;69(11):25-29
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Nov 15;69(11):25-29
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Heng J, Li Z, Liu L, Zheng Z, Zheng Y, Xu X, Liao L, Xu H, Huang H, Li E, Xu L
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
Melatonin ameliorates histone modification disorders in mammalian aged oocytes by neutralizing the alkylation of HDAC1.
He Y, Gao M, Yang W, Sun S, Wang Q, Gu L
Free radical biology & medicine 2023 Nov 1;208:361-370
Free radical biology & medicine 2023 Nov 1;208:361-370
Gigaxonin is required for intermediate filament transport.
Renganathan B, Zewe JP, Cheng Y, Paumier JM, Kittisopikul M, Ridge KM, Opal P, Gelfand VI
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22886
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22886
An A-kinase anchoring protein (ACBD3) coordinates traffic-induced PKA activation at the Golgi.
Jia J, Tang S, Yue X, Jing S, Zhu L, Tan C, Gao J, Du Y, Lee I, Qian Y
The Journal of biological chemistry 2023 May;299(5):104696
The Journal of biological chemistry 2023 May;299(5):104696
Microglial P2Y12 Signaling Contributes to Cisplatin-induced Pain Hypersensitivity via IL-18-mediated Central Sensitization in the Spinal Cord.
Chen XT, Chen LP, Fan LJ, Kan HM, Wang ZZ, Qian B, Pan ZQ, Shen W
The journal of pain 2023 May;24(5):901-917
The journal of pain 2023 May;24(5):901-917
Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders.
Lv J, Hu Y, Li L, He Y, Wang J, Guo N, Fang Y, Chen Q, Cai C, Tong J, Tang L, Wang Z
Metabolism: clinical and experimental 2023 May;142:155528
Metabolism: clinical and experimental 2023 May;142:155528
Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice.
He C, Miyazawa T, Abe C, Ueno T, Suzuki M, Mizukami M, Kurihara K, Toda M
International journal of molecular sciences 2023 May 27;24(11)
International journal of molecular sciences 2023 May 27;24(11)
Deletion of Arrb2 Down-regulates Autophagy in the Mouse Hippocampus via Akt-mTOR Pathway Activation.
Peng Q, Liu Y, Yu L, Shen Y, Li F, Feng S, Chen F
Neuroscience 2023 May 21;519:120-130
Neuroscience 2023 May 21;519:120-130
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Li J, Sun Y, Xue C, Yang X, Duan Y, Zhao D, Han J
Life sciences 2023 May 15;321:121571
Life sciences 2023 May 15;321:121571
Bmi-1 Overexpression Improves Sarcopenia Induced by 1,25(OH)(2) D(3) Deficiency and Downregulates GATA4-Dependent Rela Transcription.
Wang Q, Zhao J, Chen H, Zhou J, Chen A, Zhang J, Wang Y, Mao Z, Wang J, Qiu X, Chen Y, Wang R, Zhang Y, Miao D, Jin J
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Mar;38(3):427-442
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Mar;38(3):427-442
Inherent Capability of Self-Assembling Nanostructures in Specific Proteasome Activation for Cancer Cell Pyroptosis.
Luo QW, Yao L, Li L, Yang Z, Zhao MM, Zheng YZ, Zhuo FF, Liu TT, Zhang XW, Liu D, Tu PF, Zeng KW
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(9):e2205531
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(9):e2205531
Human MD2 deficiency-an inborn error of immunity with pleiotropic features.
Li Y, Yu Z, Schenk M, Lagovsky I, Illig D, Walz C, Rohlfs M, Conca R, Muise AM, Snapper SB, Uhlig HH, Garty BZ, Klein C, Kotlarz D
The Journal of allergy and clinical immunology 2023 Mar;151(3):791-796.e7
The Journal of allergy and clinical immunology 2023 Mar;151(3):791-796.e7
Identification of novel NFKB1 and ICOS frameshift variants in patients with CVID.
Liu A, Liu Q, Leng S, Zhang X, Feng Q, Peng J, Feng G
Clinical and experimental immunology 2023 Mar 8;211(1):68-77
Clinical and experimental immunology 2023 Mar 8;211(1):68-77
Effect of dermatopontin on osteogenic differentiation of periodontal ligament stem cells.
Zhao X, Xie Z, Rao N, Zhang S, Zhang Y
Gene 2023 Mar 30;858:147185
Gene 2023 Mar 30;858:147185
NUSAP1 Binds ILF2 to Modulate R-Loop Accumulation and DNA Damage in Prostate Cancer.
Chiu CL, Li CG, Verschueren E, Wen RM, Zhang D, Gordon CA, Zhao H, Giaccia AJ, Brooks JD
International journal of molecular sciences 2023 Mar 26;24(7)
International journal of molecular sciences 2023 Mar 26;24(7)
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
Wei P, He Q, Liu T, Zhang J, Shi K, Zhang J, Liu S
Journal of ethnopharmacology 2023 Mar 25;304:116095
Journal of ethnopharmacology 2023 Mar 25;304:116095
The Regulation of ZIP8 by Dietary Manganese in Mice.
Yu S, Zhao N
International journal of molecular sciences 2023 Mar 22;24(6)
International journal of molecular sciences 2023 Mar 22;24(6)
The Effect of Cholesterol Efflux on Endothelial Dysfunction Caused by Oxidative Stress.
Ye H, Liu Q, Wang Y, Zhen X, Yan N
International journal of molecular sciences 2023 Mar 21;24(6)
International journal of molecular sciences 2023 Mar 21;24(6)
CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasis.
Zhang B, Ren Z, Zheng H, Lin M, Chen G, Luo OJ, Zhu G
iScience 2023 Mar 17;26(3):106099
iScience 2023 Mar 17;26(3):106099
The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma.
Besse L, Kraus M, Besse A, Driessen C, Tarantino I
Scientific reports 2023 Mar 17;13(1):4411
Scientific reports 2023 Mar 17;13(1):4411
CD8+ T cell-Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance.
Lao L, Zeng W, Huang P, Chen H, Jia Z, Wang P, Huang D, Chen J, Nie Y, Yang L, Wu W, Liu J
Cancer immunology research 2023 Mar 1;11(3):320-338
Cancer immunology research 2023 Mar 1;11(3):320-338
TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate.
Miura M, Sakaue F, Matsuno H, Morita K, Yoshida A, Hara RI, Nishimura R, Nishida Y, Yokogawa M, Osawa M, Yokota T
FEBS letters 2023 Jun;597(12):1667-1676
FEBS letters 2023 Jun;597(12):1667-1676
Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinoma.
Du R, Li K, Zhou Z, Huang Y, Guo K, Zhang H, Chen Z, Zhao X, Han L, Bian H
Oncology reports 2023 Jun;49(6)
Oncology reports 2023 Jun;49(6)
"Untargeting" autoantibodies using genome editing, a proof-of-concept study.
Keppeke GD, Diogenes L, Gomes K, Andrade LEC
Clinical immunology (Orlando, Fla.) 2023 Jun;251:109343
Clinical immunology (Orlando, Fla.) 2023 Jun;251:109343
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.
Hu X, Zou R, Zhang Z, Ji J, Li J, Huo XY, Liu D, Ge MX, Cui MK, Wu MZ, Li ZP, Wang Q, Zhang X, Zhang ZR
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Jun;1866(2):194937
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Jun;1866(2):194937
HSPA5, as a ferroptosis regulator, may serve as a potential therapeutic for head and neck squamous cell carcinoma.
Li J, Xiao W, Wei W, Wu M, Xiong K, Lyu J, Li Y
Molecular immunology 2023 Jun;158:79-90
Molecular immunology 2023 Jun;158:79-90
Sunitinib attenuates reactive MDSCs enhancing anti-tumor immunity in HNSCC.
Liu J, Lin WP, Su W, Wu ZZ, Yang QC, Wang S, Sun TG, Huang CF, Wang XL, Sun ZJ
International immunopharmacology 2023 Jun;119:110243
International immunopharmacology 2023 Jun;119:110243
Differential intracellular trafficking of extracellular vesicles in microglia and astrocytes.
Pantazopoulou M, Lamprokostopoulou A, Karampela DS, Alexaki A, Delis A, Coens A, Samiotaki M, Kriebardis AG, Melki R, Pagakis SN, Stefanis L, Vekrellis K
Cellular and molecular life sciences : CMLS 2023 Jun 30;80(7):193
Cellular and molecular life sciences : CMLS 2023 Jun 30;80(7):193
Chemotherapeutic drugs-induced pyroptosis mediated by gasdermin E promotes the progression and chemoresistance of pancreatic cancer.
Li S, Yue M, Xu H, Zhang X, Mao T, Quan M, Ma J, Wang Y, Ge W, Wang Y, Xue S, Shentu D, Cui J, Wang L
Cancer letters 2023 Jun 28;564:216206
Cancer letters 2023 Jun 28;564:216206
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O
Journal of ovarian research 2023 Jun 27;16(1):122
Journal of ovarian research 2023 Jun 27;16(1):122
DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice.
Zhang WB, Huang Y, Guo XR, Zhang MQ, Yuan XS, Zu HB
Acta neuropathologica communications 2023 Jun 21;11(1):102
Acta neuropathologica communications 2023 Jun 21;11(1):102
Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.
Yang QC, Wang S, Liu YT, Song A, Wu ZZ, Wan SC, Li HM, Sun ZJ
iScience 2023 Jun 16;26(6):106916
iScience 2023 Jun 16;26(6):106916
An In Vivo CRISPR Screen Identifies That SNRPC Promotes Triple-Negative Breast Cancer Progression.
Lu XX, Yang WX, Pei YC, Luo H, Li XG, Wang YJ, Zhang GL, Ling H, Shao ZM, Hu X
Cancer research 2023 Jun 15;83(12):2000-2015
Cancer research 2023 Jun 15;83(12):2000-2015
Role of ADAM33 short isoform as a tumor suppressor in the pathogenesis of thyroid cancer via oncogenic function disruption of full-length ADAM33.
Lan J, Zhou Y, Liu Y, Xia Y, Wan Y, Cao J
Human cell 2023 Jul;36(4):1451-1463
Human cell 2023 Jul;36(4):1451-1463
PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
Shang H, Xu A, Yan H, Xu D, Zhang J, Fang X
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):763-776
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):763-776
LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla.
Zhang S, Chen G, Wang X, Tong L, Wang L, Liu T, Zhu L, Zhou S, Liu H, Du D
CNS neuroscience & therapeutics 2023 Jul;29(7):1830-1847
CNS neuroscience & therapeutics 2023 Jul;29(7):1830-1847
PDZD8-mediated endoplasmic reticulum-mitochondria associations regulate sympathetic drive and blood pressure through the intervention of neuronal mitochondrial homeostasis in stress-induced hypertension.
Liu T, Wang L, Chen G, Tong L, Ye X, Yang H, Liu H, Zhang H, Lu W, Zhang S, Du D
Neurobiology of disease 2023 Jul;183:106173
Neurobiology of disease 2023 Jul;183:106173
Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.
Zheng J, Wang S, Zhang T, Li H, Zhu M, Wei X, Ge Y, Yang X, Zhang S, Xu H, Duan Y, Liu L, Chen Y
International immunopharmacology 2023 Jul;120:110378
International immunopharmacology 2023 Jul;120:110378
Hierarchically Injectable Hydrogel Sequentially Delivers AntagomiR-467a-3p-Loaded and AntagomiR-874-5p-Loaded Satellite-Cell-Targeting Bioengineered Extracellular Vesicles Attenuating Sarcopenia.
Dai H, Luo J, Deng L, Song C, Deng Z, Wu Y, Gu S, Xu J
Advanced healthcare materials 2023 Jul;12(17):e2203056
Advanced healthcare materials 2023 Jul;12(17):e2203056
Conoidin A, a Covalent Inhibitor of Peroxiredoxin 2, Reduces Growth of Glioblastoma Cells by Triggering ROS Production.
Szeliga M, Rola R
Cells 2023 Jul 26;12(15)
Cells 2023 Jul 26;12(15)
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles.
Beusch I, Rao B, Studer MK, Luhovska T, Šukytė V, Lei S, Oses-Prieto J, SeGraves E, Burlingame A, Jonas S, Madhani HD
Molecular cell 2023 Jul 20;83(14):2578-2594.e9
Molecular cell 2023 Jul 20;83(14):2578-2594.e9
Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model.
Sutton C, Nozawa K, Kent K, Saltzman A, Leng M, Nagarajan S, Malovannaya A, Ikawa M, Garcia TX, Matzuk MM
Scientific reports 2023 Jul 14;13(1):11374
Scientific reports 2023 Jul 14;13(1):11374
Hepatic DKK1-driven steatosis is CD36 dependent.
Yang Z, Huang X, Zhang J, You K, Xiong Y, Fang J, Getachew A, Cheng Z, Yu X, Wang Y, Wu F, Wang N, Feng S, Lin X, Yang F, Chen Y, Wei H, Li YX
Life science alliance 2023 Jan;6(1)
Life science alliance 2023 Jan;6(1)
p53 downregulates PD-L1 expression via miR-34a to inhibit the growth of triple-negative breast cancer cells: a potential clinical immunotherapeutic target.
Deng S, Wang M, Wang C, Zeng Y, Qin X, Tan Y, Liang B, Cao Y
Molecular biology reports 2023 Jan;50(1):577-587
Molecular biology reports 2023 Jan;50(1):577-587
De Novo Somatic Mosaicism of CYBB Caused by Intronic LINE-1 Element Insertion Resulting in Chronic Granulomatous Disease.
Yu L, Li W, Lv G, Sun G, Yang L, Chen J, Zhou L, Ding Y, Zhang Z, Tang X, An Y, Zhao X
Journal of clinical immunology 2023 Jan;43(1):88-100
Journal of clinical immunology 2023 Jan;43(1):88-100
CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype.
Zeng W, Xiong L, Wu W, Li S, Liu J, Yang L, Lao L, Huang P, Zhang M, Chen H, Miao N, Lin Z, Liu Z, Yang X, Wang J, Wang P, Song E, Yao Y, Nie Y, Chen J, Huang D
Oncogene 2023 Jan;42(3):224-237
Oncogene 2023 Jan;42(3):224-237
The novel sustained 3-hydroxybutyrate donor poly-D-3-hydroxybutyric acid prevents inflammatory bowel disease through upregulation of regulatory T-cells.
Suzuki R, Mishima M, Nagane M, Mizugaki H, Suzuki T, Komuro M, Shimizu T, Fukuyama T, Takeda S, Ogata M, Miyamoto T, Aihara N, Kamiie J, Kamisuki S, Yokaryo H, Yamashita T, Satoh T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22708
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22708
IKKα aggravates renal fibrogenesis by positively regulating the Wnt/β-catenin pathway.
Zhang H, Pan B, Huang W, Ma M, Zhang F, Jiang L, Qian C, Wan X, Cao C
Immunology 2023 Jan;168(1):120-134
Immunology 2023 Jan;168(1):120-134
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.
He Y, B'nai Taub A, Yu L, Yao Y, Zhang R, Zahr T, Aaron N, LeSauter J, Fan L, Liu L, Tazebay R, Que J, Pajvani U, Wang L, Silver R, Qiang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2204190
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2204190
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
He W, Cheng Z, Huo Z, Lin B, Wang X, Sun Y, Yu S, Cao S, Xue J, Liu R, Lv W, Li Y, Hong S, Xiao H
Endocrinology 2023 Jan 9;164(3)
Endocrinology 2023 Jan 9;164(3)
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability.
Caballero-Ruiz B, Gkotsi DS, Ollerton H, Morales-Alcala CC, Bordone R, Jenkins GML, Di Magno L, Canettieri G, Riobo-Del Galdo NA
Cancers 2023 Jan 6;15(2)
Cancers 2023 Jan 6;15(2)
Lactate metabolism is essential in early-onset mitochondrial myopathy.
Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P
Science advances 2023 Jan 4;9(1):eadd3216
Science advances 2023 Jan 4;9(1):eadd3216
PCIF1-mediated deposition of 5'-cap N(6),2'-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection.
Wang L, Wang S, Wu L, Li W, Bray W, Clark AE, Gonzalez GM, Wang Y, Carlin AF, Rana TM
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 31;120(5):e2210361120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 31;120(5):e2210361120
Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis.
Lin Y, Dai H, Yu G, Song C, Liu J, Xu J
Journal of orthopaedic surgery and research 2023 Jan 30;18(1):73
Journal of orthopaedic surgery and research 2023 Jan 30;18(1):73
Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.
Wang L, Wu L, Zhu Z, Zhang Q, Li W, Gonzalez GM, Wang Y, Rana TM
The EMBO journal 2023 Jan 16;42(2):e111673
The EMBO journal 2023 Jan 16;42(2):e111673
Polycationic PAMAM ameliorates obesity-associated chronic inflammation and focal adiposity.
Huang B, Wan Q, Li T, Yu L, Du W, Calhoun C, Leong KW, Qiang L
Biomaterials 2023 Feb;293:121850
Biomaterials 2023 Feb;293:121850
miRNA‑92a inhibits vascular smooth muscle cell phenotypic modulation and may help prevent in‑stent restenosis.
Jiang F, Zhang B, Zhang X, Zhang R, Lu Q, Shi F, Xu J, Deng L
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Liang X, Wei Y, Hou X, Guo Q, Liang H, Zeng K, Tu P, Zhang Q
Phytochemistry 2023 Feb;206:113530
Phytochemistry 2023 Feb;206:113530
Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening.
Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM
Journal of medicinal chemistry 2023 Feb 9;66(3):2143-2160
Journal of medicinal chemistry 2023 Feb 9;66(3):2143-2160
Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.
Kong LR, Chen XH, Sun Q, Zhang KY, Xu L, Ding L, Zhou YP, Zhang ZB, Lin JR, Gao PJ
Cell reports 2023 Feb 28;42(2):112078
Cell reports 2023 Feb 28;42(2):112078
Genetic background strongly influences the transition to chronic kidney disease of adriamycin nephropathy in mice.
Watanabe M, Hiura K, Sasaki H, Okamura T, Sasaki N
Experimental animals 2023 Feb 21;72(1):47-54
Experimental animals 2023 Feb 21;72(1):47-54
PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis.
Jia L, Li D, Wang YN, Zhang D, Xu X
Journal of translational medicine 2023 Feb 2;21(1):70
Journal of translational medicine 2023 Feb 2;21(1):70
BRPF1 bridges H3K4me3 and H3K23ac in human embryonic stem cells and is essential to pluripotency.
Zhang C, Lin H, Zhang Y, Xing Q, Zhang J, Zhang D, Liu Y, Chen Q, Zhou T, Wang J, Shan Y, Pan G
iScience 2023 Feb 17;26(2):105939
iScience 2023 Feb 17;26(2):105939
Effect of Zbed6 Single-Allele Knockout on the Growth and Development of Skeletal Muscle in Mice.
Liu L, Wang S, Tian W, Xu C, Wei C, Cui K, Jiang L, Wang D
Biology 2023 Feb 17;12(2)
Biology 2023 Feb 17;12(2)
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
Hu Y, Jiang H, Xu Y, Chen G, Fan R, Zhou Y, Liu Y, Yao Y, Liu R, Chen W, Zhang K, Chen X, Wang R, Qiu Z
Cell death discovery 2023 Feb 14;9(1):63
Cell death discovery 2023 Feb 14;9(1):63
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P, Perret M, Liu Z, Jordan I, Elmas Bozdemir S, Bayhan GI, Beaufils C, Bizien L, Bisiaux A, Lei W, Hasan M, Chen J, Gaughan C, Asthana A, Libri V, Luna JM, Jaffré F, Hoffmann HH, Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flores C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Le Voyer T, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T, Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumadó V, DeDiego ML, Fidouh N, Rozenberg F, Pérez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval X, CoV-Contact Cohort§, COVID Human Genetic Effort¶, Pan-Hammarström Q, Planas AM, Meyts I, Haerynck F, Pujol A, Sancho-Shimizu V, Dalgard CL, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Béziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton RP, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL
Science (New York, N.Y.) 2023 Feb 10;379(6632):eabo3627
Science (New York, N.Y.) 2023 Feb 10;379(6632):eabo3627
Mitotic spindle positioning protein (MISP) deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis in mice.
Hiura K, Maruyama T, Watanabe M, Nakano K, Okamura T, Sasaki H, Sasaki N
The Journal of veterinary medical science 2023 Feb 1;85(2):167-174
The Journal of veterinary medical science 2023 Feb 1;85(2):167-174
The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice.
Qin X, Xie C, Hakenjos JM, MacKenzie KR, Boyd SR, Barzi M, Bissig KD, Young DW, Li F
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023 Feb 1;181:106358
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023 Feb 1;181:106358
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production.
Song J, Lv H, Liu B, Hao M, Taylor HS, Zhang X, Li D, Huang Y
Molecular metabolism 2023 Dec;78:101828
Molecular metabolism 2023 Dec;78:101828
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y
Redox biology 2023 Dec;68:102944
Redox biology 2023 Dec;68:102944
A novel homozygous Y140X mutation of ISG15 causes diverse type I interferonopathies in sibling patients with cutaneous lesions or recurrent parenchymal pneumonia.
Xu Q, Li W, Zhao Q, Zhao L, Lv G, Sun G, Gao Y, Ding Y, Zhang Z, Zhou L, Chen Y, Tang X, Zhu J, Zhao X, An Y
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109844
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109844
METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis.
Chen Y, Wu Y, Fang L, Zhao H, Xu S, Shuai Z, Yu H, Cai G, Zhan HQ, Pan F
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109838
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109838
Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
Chen Y, Li Q, Zhao S, Sun L, Yin Z, Wang X, Li X, Iwakiri Y, Han J, Duan Y
Biochemical pharmacology 2023 Dec;218:115928
Biochemical pharmacology 2023 Dec;218:115928
GmPLP1 negatively regulates soybean resistance to high light stress by modulating photosynthetic capacity and reactive oxygen species accumulation in a blue light-dependent manner.
Zhang Y, Zheng J, Zhan Y, Yu Z, Liu S, Lu X, Li Y, Li Z, Liang X, Li H, Feng Y, Teng W, Li W, Han Y, Zhao X, Li Y
Plant biotechnology journal 2023 Dec;21(12):2625-2640
Plant biotechnology journal 2023 Dec;21(12):2625-2640
The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation.
Wei X, Shen Z, Zhu M, Fang M, Wang S, Zhang T, Zhang B, Yang X, Lv Z, Duan Y, Jiang M, Ma C, Li Q, Chen Y
International immunopharmacology 2023 Dec;125(Pt B):111198
International immunopharmacology 2023 Dec;125(Pt B):111198
BPTF Drives Gastric Cancer Resistance to EGFR Inhibitor by Epigenetically Regulating the C-MYC/PLCG1/Perk Axis.
Li F, Yu J, Pan T, Feng H, Li J, Yu B, Fan Z, Sang Q, Chen M, Zang M, Hou J, Wu X, Yu Y, Li YY, Yan C, Zhu Z, Su L, Liu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2303091
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2303091
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
CREB1 Facilitates GABAergic Neural Differentiation of Human Mesenchymal Stem Cells through BRN2 for Pain Alleviation and Locomotion Recovery after Spinal Cord Injury.
Kao Y, Zhu H, Yang Y, Shen W, Song W, Zhang R, Liu Y, Liu H, Kong X
Cells 2023 Dec 28;13(1)
Cells 2023 Dec 28;13(1)
Choroid plexus mast cells drive tumor-associated hydrocephalus.
Li Y, Di C, Song S, Zhang Y, Lu Y, Liao J, Lei B, Zhong J, Guo K, Zhang N, Su S
Cell 2023 Dec 21;186(26):5719-5738.e28
Cell 2023 Dec 21;186(26):5719-5738.e28
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Zhu C, Zhou Q, Wang Z, Zhang J, Xu C, Ruan D
Molecular biology reports 2023 Aug;50(8):6337-6347
Molecular biology reports 2023 Aug;50(8):6337-6347
Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease.
Wang M, Gong K, Zhu X, Chen S, Zhou J, Zhang H, Han J, Ma L, Duan Y
MedComm 2023 Aug;4(4):e320
MedComm 2023 Aug;4(4):e320
Single amino acid-based PROTACs trigger degradation of the oncogenic kinase BCR-ABL in chronic myeloid leukemia (CML).
Zhang J, Ma C, Yu Y, Liu C, Fang L, Rao H
The Journal of biological chemistry 2023 Aug;299(8):104994
The Journal of biological chemistry 2023 Aug;299(8):104994
Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin.
Deng DX, Li CY, Zheng ZY, Wen B, Liao LD, Zhang XJ, Li EM, Xu LY
Molecular & cellular proteomics : MCP 2023 Aug;22(8):100593
Molecular & cellular proteomics : MCP 2023 Aug;22(8):100593
Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy.
Tran QTN, Gan PXL, Liao W, Mok YK, Chai CLL, Wong WSF
Pharmacological research 2023 Aug;194:106861
Pharmacological research 2023 Aug;194:106861
Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition.
Wang X, Sun Z, Yang T, Lin F, Ye S, Yan J, Li T, Chen J
mSystems 2023 Aug 31;8(4):e0041523
mSystems 2023 Aug 31;8(4):e0041523
OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer.
Xie X, Laster KV, Li J, Nie W, Yi YW, Liu K, Seong YS, Dong Z, Kim DJ
Cellular and molecular life sciences : CMLS 2023 Aug 30;80(9):272
Cellular and molecular life sciences : CMLS 2023 Aug 30;80(9):272
Haspin balances the ratio of asymmetric cell division through Wnt5a and regulates cell fate decisions in mouse embryonic stem cells.
Gao Y, Ma B, Li Y, Wu X, Zhao S, Guo H, Wang Y, Sun L, Xie J
Cell death discovery 2023 Aug 23;9(1):307
Cell death discovery 2023 Aug 23;9(1):307
XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
Kuang M, Zhao Y, Yu H, Li S, Liu T, Chen L, Chen J, Luo Y, Guo X, Wei X, Li Y, Zhang Z, Wang D, You F
Science advances 2023 Aug 18;9(33):eadg5211
Science advances 2023 Aug 18;9(33):eadg5211
Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to -4) Using a Newly Developed DENV-3 Infectious Clone and Replicon.
Hu M, Li WF, Wu T, Yang Y, Chen G, Chen T, Liu Y, Mei Y, Wu D, Wei Y, Luo T, Zhang HJ, Li YP
Microbiology spectrum 2023 Aug 17;11(4):e0042323
Microbiology spectrum 2023 Aug 17;11(4):e0042323
Expression and function of patatin-like phospholipase domain-containing 2 in cleft palate induced by retinoic acid.
Ye QN, Zheng K
The British journal of oral & maxillofacial surgery 2023 Apr;61(3):215-220
The British journal of oral & maxillofacial surgery 2023 Apr;61(3):215-220
A neuron-specific Isca1 knockout rat developments multiple mitochondrial dysfunction syndromes.
Sheng H, Lu D, Qi X, Ling Y, Li J, Zhang X, Dong W, Chen W, Gao S, Gao X, Zhang L, Zhang L
Animal models and experimental medicine 2023 Apr;6(2):155-167
Animal models and experimental medicine 2023 Apr;6(2):155-167
Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer.
Gui S, Wang Q, Bao L, He X, Wang Z, Liu L, Wu L, Zhao Y, Zhou J, Xie Y
Oncology letters 2023 Apr;25(4):143
Oncology letters 2023 Apr;25(4):143
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
Wang J, Wang D, Feng L, Li X, Gong Y, Wang Z, Tan N, Han J
Phytochemistry 2023 Apr;208:113603
Phytochemistry 2023 Apr;208:113603
Conserved NIMA kinases regulate multiple steps of endocytic trafficking.
Joseph BB, Naslavsky N, Binti S, Conquest S, Robison L, Bai G, Homer RO, Grant BD, Caplan S, Fay DS
PLoS genetics 2023 Apr;19(4):e1010741
PLoS genetics 2023 Apr;19(4):e1010741
NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).
Hao J, Li J, Zhang Z, Yang Y, Zhou Q, Wu T, Chen T, Wu Z, Zhang P, Cui J, Li YP
Autophagy 2023 Apr;19(4):1332-1347
Autophagy 2023 Apr;19(4):1332-1347
KDEL Receptor Trafficking to the Plasma Membrane Is Regulated by ACBD3 and Rab4A-GTP.
Tan C, Du Y, Zhu L, Jing S, Gao J, Qian Y, Yue X, Lee I
Cells 2023 Apr 4;12(7)
Cells 2023 Apr 4;12(7)
Gomisin D alleviates liver fibrosis through targeting PDGFRβ in hepatic stellate cells.
Wang R, Liu F, Chen P, Li S, Gu Y, Wang L, Chen C, Yuan Y
International journal of biological macromolecules 2023 Apr 30;235:123639
International journal of biological macromolecules 2023 Apr 30;235:123639
A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns.
Tang Y, Han Y, Zhao J, Lv Y, Fan C, Zheng L, Zhang Z, Liu Z, Li C, Lin Y
Nano-micro letters 2023 Apr 30;15(1):112
Nano-micro letters 2023 Apr 30;15(1):112
FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.
Yang YS, Liu MH, Yan ZW, Chen GQ, Huang Y
Stem cells (Dayton, Ohio) 2023 Apr 25;41(4):354-367
Stem cells (Dayton, Ohio) 2023 Apr 25;41(4):354-367
A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model.
Lv H, Catarino J, Li D, Liu B, Gao XB, Horvath TL, Huang Y
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 18;120(16):e2300015120
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 18;120(16):e2300015120
Syndecan-1 as an immunogene in Triple-negative breast cancer: regulation tumor-infiltrating lymphocyte in the tumor microenviroment and EMT by TGFb1/Smad pathway.
Zhong Y, Li F, Zhang S, Yang Z, Ren X, Cao X, Xu Y, Guo D, Zhou Y, Mao F, Shen S, Sun Q
Cancer cell international 2023 Apr 17;23(1):76
Cancer cell international 2023 Apr 17;23(1):76
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
Wen B, Deng DX, Liao LD, Zhang ZD, Zheng YQ, Dong K, Xu LY, Li EM
Biomedicines 2023 Apr 16;11(4)
Biomedicines 2023 Apr 16;11(4)
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Tan L, Qi X, Kong W, Jin J, Lu D, Zhang X, Wang Y, Wang S, Dong W, Shi X, Chen W, Wang J, Li K, Xie Y, Gao L, Guan F, Gao K, Li C, Wang C, Hu Z, Zhang L, Guo X, Shen B, Ma Y
Science advances 2023 Apr 14;9(15):eadf2695
Science advances 2023 Apr 14;9(15):eadf2695
Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain.
Babiec L, Wilkaniec A, Adamczyk A
Folia neuropathologica 2022;60(4):390-402
Folia neuropathologica 2022;60(4):390-402
Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer.
Chen A, Xu M, Chen J, Chen T, Wang Q, Zhang R, Qiu J
BioMed research international 2022;2022:6207701
BioMed research international 2022;2022:6207701
Artemin Promotes the Migration and Invasion of Cervical Cancer Cells through AKT/mTORC1 Signaling.
Zhu M, Zhou L, Fu J, Wang Y, Xu X, Wu J, Kong X, Li J, Zhou Z, Zhou H
Journal of oncology 2022;2022:3332485
Journal of oncology 2022;2022:3332485
Elevated FOXA1 Expression Indicates Poor Prognosis in Liver Cancer due to Its Effects on Cell Proliferation and Metastasis.
Liu Z, Wang Y, Aizimuaji Z, Ma S, Xiao T
Disease markers 2022;2022:3317315
Disease markers 2022;2022:3317315
Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.
Qian Z, Chen H, Xia M, Chang J, Li X, Ye S, Wu S, Jiang S, Bao J, Wang B, Kong R, Zhang S, Zheng S, Cao X, Hong X
International journal of biological sciences 2022;18(4):1328-1346
International journal of biological sciences 2022;18(4):1328-1346
Growth Differentiation Factor 15 Regulates Oxidative Stress-Dependent Ferroptosis Post Spinal Cord Injury by Stabilizing the p62-Keap1-Nrf2 Signaling Pathway.
Xia M, Zhang Q, Zhang Y, Li R, Zhao T, Chen L, Liu Q, Zheng S, Li H, Qian Z, Yang L
Frontiers in aging neuroscience 2022;14:905115
Frontiers in aging neuroscience 2022;14:905115
Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.
Jiang F, Xia M, Zhang Y, Chang J, Cao J, Zhang Z, Qian Z, Yang L
Frontiers in immunology 2022;13:993168
Frontiers in immunology 2022;13:993168
Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis.
Wang C, Ma H, Zhang B, Hua T, Wang H, Wang L, Han L, Li Q, Wu W, Sun Y, Yang H, Lu X
Frontiers in immunology 2022;13:963582
Frontiers in immunology 2022;13:963582
Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1.
Cao Y, Yang L, Cheng H
Frontiers in pharmacology 2022;13:941094
Frontiers in pharmacology 2022;13:941094
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Sun J, Wei J, Zhang Y, Li J, Li J, Yan J, Guo M, Han J, Qiao H
Frontiers in immunology 2022;13:819680
Frontiers in immunology 2022;13:819680
Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy.
Ueno D, Vasquez JC, Sule A, Liang J, van Doorn J, Sundaram R, Friedman S, Caliliw R, Ohtake S, Bao X, Li J, Ye H, Boyd K, Huang RR, Dodson J, Boutros P, Bindra RS, Shuch B
Oncotarget 2022;13:1054-1067
Oncotarget 2022;13:1054-1067
Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis.
Ghosh S, Singh R, Vanwinkle ZM, Guo H, Vemula PK, Goel A, Haribabu B, Jala VR
Theranostics 2022;12(12):5574-5595
Theranostics 2022;12(12):5574-5595
A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C.
West G, Turunen M, Aalto A, Virtanen L, Li SP, Heliö T, Meinander A, Taimen P
Frontiers in cell and developmental biology 2022;10:932983
Frontiers in cell and developmental biology 2022;10:932983
Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.
Wang H, Cui Y, Gong H, Xu J, Huang S, Tang A
Frontiers in bioengineering and biotechnology 2022;10:929979
Frontiers in bioengineering and biotechnology 2022;10:929979
Ruxolitinib attenuates secondary injury after traumatic spinal cord injury.
Qian ZY, Kong RY, Zhang S, Wang BY, Chang J, Cao J, Wu CQ, Huang ZY, Duan A, Li HJ, Yang L, Cao XJ
Neural regeneration research 2022 Sep;17(9):2029-2035
Neural regeneration research 2022 Sep;17(9):2029-2035
Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy.
Yeh HH, Chang YM, Chang YW, Lu MJ, Chen YH, Lee CC, Chen CC
Journal of molecular and cellular cardiology plus 2022 Sep;1:100011
Journal of molecular and cellular cardiology plus 2022 Sep;1:100011
MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer.
Gao Y, Fang Y, Huang Y, Ma R, Chen X, Wang F, Pei X, Gao Y, Chen X, Liu X, Shan J, Li P
Cell death & disease 2022 Sep 21;13(9):810
Cell death & disease 2022 Sep 21;13(9):810
Pangenomic analysis of Chinese gastric cancer.
Yu Y, Zhang Z, Dong X, Yang R, Duan Z, Xiang Z, Li J, Li G, Yan F, Xue H, Jiao D, Lu J, Lu H, Zhang W, Wei Y, Fan S, Li J, Jia J, Zhang J, Ji J, Liu P, Lu H, Zhao H, Chen S, Wei C, Chen H, Zhu Z
Nature communications 2022 Sep 15;13(1):5412
Nature communications 2022 Sep 15;13(1):5412
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.
Monterisi S, Michl J, Hulikova A, Koth J, Bridges EM, Hill AE, Abdullayeva G, Bodmer WF, Swietach P
eLife 2022 Sep 15;11
eLife 2022 Sep 15;11
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.
Bondi CD, Rush BM, Hartman HL, Wang J, Al-Bataineh MM, Hughey RP, Tan RJ
Antioxidants (Basel, Switzerland) 2022 Sep 14;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 14;11(9)
E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma.
Chen M, Zhao Z, Wu L, Huang J, Yu P, Qian J, Ni T, Zhao C
Cell death & disease 2022 Sep 12;13(9):784
Cell death & disease 2022 Sep 12;13(9):784
Suppression of macrophage-mediated xenogeneic rejection by the ectopic expression of human CD177.
Kogata S, Lo PC, Maeda A, Okamatsu C, Sato K, Yamamoto R, Haneda T, Yoneyama T, Toyama C, Eguchi H, Masahata K, Kamiyama M, Okuyama H, Miyagawa S
Transplant immunology 2022 Oct;74:101663
Transplant immunology 2022 Oct;74:101663
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho.
Zhou W, Chen MM, Liu HL, Si ZL, Wu WH, Jiang H, Wang LX, Vaziri ND, An XF, Su K, Chen C, Tan NH, Zhang ZH
Acta pharmacologica Sinica 2022 Oct;43(10):2609-2623
Acta pharmacologica Sinica 2022 Oct;43(10):2609-2623
A non-metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11-mediated CD133 stability.
Wang J, Shao F, Yang Y, Wang W, Yang X, Li R, Cheng H, Sun S, Feng X, Gao Y, He J, Lu Z
Cancer communications (London, England) 2022 Oct;42(10):1008-1027
Cancer communications (London, England) 2022 Oct;42(10):1008-1027
Autoregulation of H(+)/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.
Blaszczak W, Williams H, Swietach P
British journal of cancer 2022 Oct;127(7):1365-1377
British journal of cancer 2022 Oct;127(7):1365-1377
Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.
Xia M, Zhang Y, Wu H, Zhang Q, Liu Q, Li G, Zhao T, Liu X, Zheng S, Qian Z, Li H
International immunopharmacology 2022 Oct;111:109120
International immunopharmacology 2022 Oct;111:109120
Identification of SLC3A2 as a Potential Therapeutic Target of Osteoarthritis Involved in Ferroptosis by Integrating Bioinformatics, Clinical Factors and Experiments.
Liu H, Deng Z, Yu B, Liu H, Yang Z, Zeng A, Fu M
Cells 2022 Oct 30;11(21)
Cells 2022 Oct 30;11(21)
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.
Pan L, Li C, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G, Zhang Z
Brain : a journal of neurology 2022 Oct 21;145(10):3454-3471
Brain : a journal of neurology 2022 Oct 21;145(10):3454-3471
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Zhou W, Wu WH, Si ZL, Liu HL, Wang H, Jiang H, Liu YF, Alolga RN, Chen C, Liu SJ, Bian XY, Shan JJ, Li J, Tan NH, Zhang ZH
Nature communications 2022 Oct 14;13(1):6081
Nature communications 2022 Oct 14;13(1):6081
Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome.
Wei Z, Shimizu K, Sarii RS, Muthusinghe DS, Lokupathirage SMW, Nio-Kobayashi J, Yoshimatsu K
Viruses 2022 Oct 13;14(10)
Viruses 2022 Oct 13;14(10)
Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice.
Chen HY, Hong YH, Chiang YF, Wang KL, Huang TC, Ali M, Shieh TM, Chang HY, Hsia SM
Metabolites 2022 Oct 12;12(10)
Metabolites 2022 Oct 12;12(10)
Excessive activation of HOXB13/PIMREG axis promotes hepatocellular carcinoma progression and drug resistance.
Tang C, Qiu S, Mou W, Xu J, Wang P
Biochemical and biophysical research communications 2022 Oct 1;623:81-88
Biochemical and biophysical research communications 2022 Oct 1;623:81-88
Coronin2A links actin-based endosomal processes to the EHD1 fission machinery.
Dhawan K, Naslavsky N, Caplan S
Molecular biology of the cell 2022 Oct 1;33(12):ar107
Molecular biology of the cell 2022 Oct 1;33(12):ar107
Genetic and Functional Identifying of Novel STAT1 Loss-of-Function Mutations in Patients with Diverse Clinical Phenotypes.
Chen X, Chen J, Chen R, Mou H, Sun G, Yang L, Jia Y, Zhao Q, Wen W, Zhou L, Ding Y, Tang X, Yang J, An Y, Zhao X
Journal of clinical immunology 2022 Nov;42(8):1778-1794
Journal of clinical immunology 2022 Nov;42(8):1778-1794
Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability.
Hong S, Xie Y, Cheng Z, Li J, He W, Guo Z, Zhang Q, Peng S, He M, Yu S, Xu L, Liu R, Xu T, Zhang Y, Li Y, Wang J, Lv W, Yu J, Xiao H
Oncogene 2022 Nov;41(47):5121-5132
Oncogene 2022 Nov;41(47):5121-5132
Tp47 promoted the phagocytosis of HMC3 cells though autophagy induced by endoplamic reticlum stress.
Li W, Li QL, Xu QY, Wang XT, Yang TC
Journal of the European Academy of Dermatology and Venereology : JEADV 2022 Nov;36(11):2224-2234
Journal of the European Academy of Dermatology and Venereology : JEADV 2022 Nov;36(11):2224-2234
Combined Therapy of Low-Dose Angiotensin Receptor-Neprilysin Inhibitor and Sodium-Glucose Cotransporter-2 Inhibitor Prevents Doxorubicin-Induced Cardiac Dysfunction in Rodent Model with Minimal Adverse Effects.
Kim D, Jang G, Hwang J, Wei X, Kim H, Son J, Rhee SJ, Yun KH, Oh SK, Oh CM, Park R
Pharmaceutics 2022 Nov 28;14(12)
Pharmaceutics 2022 Nov 28;14(12)
Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors.
Fan Y, Zhang Y, Shi K, Cheng S, Pei D, Shu X
Cell death & disease 2022 Nov 26;13(11):1000
Cell death & disease 2022 Nov 26;13(11):1000
Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer.
Chen X, Luo R, Zhang Y, Ye S, Zeng X, Liu J, Huang D, Liu Y, Liu Q, Luo ML, Song E
Nature communications 2022 Nov 22;13(1):7160
Nature communications 2022 Nov 22;13(1):7160
Deficiency of CD93 exacerbates inflammation-induced activation and migration of BV2 microglia by regulating the TAK1/NF-κB pathway.
Hong X, Xia M, Zhang Q, Zhao T, Zhang Y, Qian Z, Bao J, Li H
Neuroscience letters 2022 Nov 20;791:136914
Neuroscience letters 2022 Nov 20;791:136914
CD16(+) fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition.
Liu X, Lu Y, Huang J, Xing Y, Dai H, Zhu L, Li S, Feng J, Zhou B, Li J, Xia Q, Li J, Huang M, Gu Y, Su S
Cancer cell 2022 Nov 14;40(11):1341-1357.e13
Cancer cell 2022 Nov 14;40(11):1341-1357.e13
Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo.
Chen HY, Chiang YF, Hong YH, Shieh TM, Huang TC, Ali M, Chang HY, Wang KL, Hsia SM
Antioxidants (Basel, Switzerland) 2022 Nov 13;11(11)
Antioxidants (Basel, Switzerland) 2022 Nov 13;11(11)
Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.
Wilson AD, Richards MA, Curtis MK, Gunadasa-Rohling M, Monterisi S, Loonat AA, Miller JJ, Ball V, Lewis A, Tyler DJ, Moshnikova A, Andreev OA, Reshetnyak YK, Carr C, Swietach P
Cardiovascular research 2022 Nov 10;118(14):2946-2959
Cardiovascular research 2022 Nov 10;118(14):2946-2959
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Tang K, Qin W, Wei R, Jiang Y, Fan L, Wang Z, Tan N
Pharmacological research 2022 May;179:106123
Pharmacological research 2022 May;179:106123
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
Wang J, Wang Y, Wang J, Zhang S, Yu Z, Zheng K, Fu Z, Wang C, Huang W, Chen J
Bioengineered 2022 May;13(5):13970-13985
Bioengineered 2022 May;13(5):13970-13985
Defining the Skeletal Myogenic Lineage in Human Pluripotent Stem Cell-Derived Teratomas.
Pappas MP, Xie N, Penaloza JS, Chan SSK
Cells 2022 May 9;11(9)
Cells 2022 May 9;11(9)
Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins.
Buchou C, Laud-Duval K, van der Ent W, Grossetête S, Zaidi S, Gentric G, Corbé M, Müller K, Del Nery E, Surdez D, Delattre O
Cancers 2022 May 8;14(9)
Cancers 2022 May 8;14(9)
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.
Xiang G, Ying K, Jiang P, Jia M, Sun Y, Li S, Wu X, Hao S
Skeletal muscle 2022 May 6;12(1):10
Skeletal muscle 2022 May 6;12(1):10
Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice.
Ren J, Huang R, Li Y, Chen R, Tian H, Liu C
Scientific reports 2022 May 19;12(1):8419
Scientific reports 2022 May 19;12(1):8419
Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.
Cheng Y, Shen Z, Gao Y, Chen F, Xu H, Mo Q, Chu X, Peng CL, McKenzie TT, Palacios BE, Hu J, Zhou H, Long J
Nature communications 2022 May 18;13(1):2724
Nature communications 2022 May 18;13(1):2724
The retromer complex regulates C. elegans development and mammalian ciliogenesis.
Xie S, Dierlam C, Smith E, Duran R, Williams A, Davis A, Mathew D, Naslavsky N, Iyer J, Caplan S
Journal of cell science 2022 May 15;135(10)
Journal of cell science 2022 May 15;135(10)
Direct targeting of amplified gene loci for proapoptotic anticancer therapy.
Kaushik Tiwari M, Colon-Rios DA, Tumu HCR, Liu Y, Quijano E, Krysztofiak A, Chan C, Song E, Braddock DT, Suh HW, Saltzman WM, Rogers FA
Nature biotechnology 2022 Mar;40(3):325-334
Nature biotechnology 2022 Mar;40(3):325-334
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
Kaneko T, Horiuchi K, Chijimatsu R, Mori D, Nagata K, Omata Y, Yano F, Inui H, Moro T, Tanaka S, Saito T
Journal of bone and mineral metabolism 2022 Mar;40(2):196-207
Journal of bone and mineral metabolism 2022 Mar;40(2):196-207
CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.
Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P
Cell reports 2022 Mar 8;38(10):110493
Cell reports 2022 Mar 8;38(10):110493
Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.
Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P
Basic research in cardiology 2022 Mar 31;117(1):17
Basic research in cardiology 2022 Mar 31;117(1):17
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.
Wang H, Lv D, Jiang S, Hou Q, Zhang L, Li S, Zhu X, Xu X, Wen J, Zeng C, Zhang M, Yang F, Chen Z, Zheng C, Li J, Zen K, Liu Z, Li L
Cell death & disease 2022 Mar 29;13(3):281
Cell death & disease 2022 Mar 29;13(3):281
Sexual dimorphic impacts of systemic vincristine on lower urinary tract function.
Iguchi N, Hecht SL, Gao D, Wilcox DT, Malykhina AP, Cost NG
Scientific reports 2022 Mar 24;12(1):5113
Scientific reports 2022 Mar 24;12(1):5113
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Zheng X, Xiao J, Jiang Q, Zheng L, Liu C, Dong C, Zheng Y, Ni P, Zhang C, Zhang F, Zhong R, Ding H, Wang Q, Qiu Y, Gao M, Ding J, Shen N, Wei B, Wang H
The EMBO journal 2022 Mar 15;41(6):e108016
The EMBO journal 2022 Mar 15;41(6):e108016
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L
Redox biology 2022 Jun;52:102292
Redox biology 2022 Jun;52:102292
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Wang Y, Jin C, Tian H, Xu J, Chen J, Hu S, Li Q, Lu L, Ou Q, Xu GT, Cui H
Experimental eye research 2022 Jun;219:108939
Experimental eye research 2022 Jun;219:108939
Up-regulation of miR-335 and miR-674-3p in the rostral ventrolateral medulla contributes to stress-induced hypertension.
Zhang S, Xing M, Chen G, Tong L, Zhang H, Du D
Journal of neurochemistry 2022 Jun;161(5):387-404
Journal of neurochemistry 2022 Jun;161(5):387-404
Pervasive translation of circular RNAs driven by short IRES-like elements.
Fan X, Yang Y, Chen C, Wang Z
Nature communications 2022 Jun 29;13(1):3751
Nature communications 2022 Jun 29;13(1):3751
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.
Watamura N, Sato K, Shiihashi G, Iwasaki A, Kamano N, Takahashi M, Sekiguchi M, Mihira N, Fujioka R, Nagata K, Hashimoto S, Saito T, Ohshima T, Saido TC, Sasaguri H
Science advances 2022 Jun 10;8(23):eabm6155
Science advances 2022 Jun 10;8(23):eabm6155
The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice.
Fung CK, Zhao N
International journal of molecular sciences 2022 Jun 10;23(12)
International journal of molecular sciences 2022 Jun 10;23(12)
MEK1/2 inhibitors induce class I alcohol dehydrogenase (ADH1) expression by regulating farnesoid X receptor in hepatic cell lines and C57BL/6J mouse.
Wang X, Yang Y, Chen Y, Duan Y, Han J, Yang X
Molecular biology reports 2022 Jul;49(7):5843-5852
Molecular biology reports 2022 Jul;49(7):5843-5852
Inhibiting uptake of extracellular vesicles derived from senescent bone marrow mesenchymal stem cells by muscle satellite cells attenuates sarcopenia.
Dai H, Zheng W, Luo J, Yu G, Song C, Wu Y, Xu J
Journal of orthopaedic translation 2022 Jul;35:23-36
Journal of orthopaedic translation 2022 Jul;35:23-36
Iron-regulated assembly of the cytosolic iron-sulfur cluster biogenesis machinery.
Fan X, Barshop WD, Vashisht AA, Pandey V, Leal S, Rayatpisheh S, Jami-Alahmadi Y, Sha J, Wohlschlegel JA
The Journal of biological chemistry 2022 Jul;298(7):102094
The Journal of biological chemistry 2022 Jul;298(7):102094
Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis.
Jones T, Naslavsky N, Caplan S
Traffic (Copenhagen, Denmark) 2022 Jul;23(7):360-373
Traffic (Copenhagen, Denmark) 2022 Jul;23(7):360-373
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice.
Tian Y, Pan L, Yuan X, Xiong M, Zhang Z, Meng L, Zheng Y, Bu L, Xu X, Zhang Z
Neurobiology of disease 2022 Jul;169:105736
Neurobiology of disease 2022 Jul;169:105736
Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.
Zhang Q, Wang S, Li W, Yau E, Hui H, Singh PK, Achuthan V, Young Karris MA, Engelman AN, Rana TM
Nucleic acids research 2022 Jul 8;50(12):6687-6701
Nucleic acids research 2022 Jul 8;50(12):6687-6701
Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.
Campbell TM, Liu Z, Zhang Q, Moncada-Velez M, Covill LE, Zhang P, Alavi Darazam I, Bastard P, Bizien L, Bucciol G, Lind Enoksson S, Jouanguy E, Karabela ŞN, Khan T, Kendir-Demirkol Y, Arias AA, Mansouri D, Marits P, Marr N, Migeotte I, Moens L, Ozcelik T, Pellier I, Sendel A, Şenoğlu, S, Shahrooei M, Smith CIE, Vandernoot I, Willekens K, Kart Yaşar K, COVID Human Genetic Effort, Bergman P, Abel L, Cobat A, Casanova JL, Meyts I, Bryceson YT
The Journal of experimental medicine 2022 Jul 4;219(7)
The Journal of experimental medicine 2022 Jul 4;219(7)
C-type lectin domain-containing protein CLEC3A regulates proliferation, regeneration and maintenance of nucleus pulposus cells.
Chen X, Ji Y, Feng F, Liu Z, Qian L, Shen H, Lao L
Cellular and molecular life sciences : CMLS 2022 Jul 21;79(8):435
Cellular and molecular life sciences : CMLS 2022 Jul 21;79(8):435
FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.
Zhang Z, Xu Y
Molecular medicine (Cambridge, Mass.) 2022 Jul 19;28(1):82
Molecular medicine (Cambridge, Mass.) 2022 Jul 19;28(1):82
DSCAM-AS1 Long Non-Coding RNA Exerts Oncogenic Functions in Endometrial Adenocarcinoma via Activation of a Tumor-Promoting Transcriptome Profile.
Treeck O, Weber F, Fritsch J, Skrzypczak M, Schüler-Toprak S, Buechler C, Ortmann O
Biomedicines 2022 Jul 18;10(7)
Biomedicines 2022 Jul 18;10(7)
UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity via modulating unfolded protein response.
Guo B, Xu X, Shao M, Yang X, He G, Qi K, Gu J, Wang L
Biochemical and biophysical research communications 2022 Jul 12;613:207-213
Biochemical and biophysical research communications 2022 Jul 12;613:207-213
PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1.
Kant S, Tran KV, Kvandova M, Caliz AD, Yoo HJ, Learnard H, Dolan AC, Craige SM, Hall JD, Jiménez JM, St Hilaire C, Schulz E, Kröller-Schön S, Keaney JF Jr
Arteriosclerosis, thrombosis, and vascular biology 2022 Jan;42(1):19-34
Arteriosclerosis, thrombosis, and vascular biology 2022 Jan;42(1):19-34
CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway.
Huang C, Du R, Jia X, Liu K, Qiao Y, Wu Q, Yao N, Yang L, Zhou L, Liu X, Xiang P, Xin M, Wang Y, Chen X, Kim DJ, Dong Z, Li X
Cell death and differentiation 2022 Jan;29(1):14-27
Cell death and differentiation 2022 Jan;29(1):14-27
Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
Yi T, Chen H, Zhan J, Li Y, Long Z, Wu Z, Yang M, Peng T, Li H
Experimental biology and medicine (Maywood, N.J.) 2022 Jan;247(2):165-173
Experimental biology and medicine (Maywood, N.J.) 2022 Jan;247(2):165-173
LRRK2 is required for CD38-mediated NAADP-Ca(2+) signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Nabar NR, Heijjer CN, Shi CS, Hwang IY, Ganesan S, Karlsson MCI, Kehrl JH
Autophagy 2022 Jan;18(1):204-222
Autophagy 2022 Jan;18(1):204-222
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.
Jiang LP, Ji JZ, Ge PX, Zhu T, Mi QY, Tai T, Li YF, Xie HG
British journal of pharmacology 2022 Jan;179(1):46-64
British journal of pharmacology 2022 Jan;179(1):46-64
Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma.
Nishino K, Nishiko Y, Shibata M, Oda Y, Watanabe E, Niimi K, Yamamoto E, Kajiyama H
Placenta 2022 Jan;117:109-117
Placenta 2022 Jan;117:109-117
Proteomic analysis of opossum Monodelphis domestica spinal cord reveals the changes of proteins related to neurodegenerative diseases during developmental period when neuroregeneration stops being possible.
Tomljanović I, Petrović A, Ban J, Mladinic M
Biochemical and biophysical research communications 2022 Jan 8;587:85-91
Biochemical and biophysical research communications 2022 Jan 8;587:85-91
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Dixit D, Prager BC, Gimple RC, Miller TE, Wu Q, Yomtoubian S, Kidwell RL, Lv D, Zhao L, Qiu Z, Zhang G, Lee D, Park DE, Wechsler-Reya RJ, Wang X, Bao S, Rich JN
Science translational medicine 2022 Jan 5;14(626):eabf3917
Science translational medicine 2022 Jan 5;14(626):eabf3917
Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.
Wang J, Zhou L, Chen B, Yu Z, Zhang J, Zhang Z, Hu C, Bai Y, Ruan X, Wang S, Ouyang J, Wu A, Zhao X
Journal of translational medicine 2022 Jan 31;20(1):58
Journal of translational medicine 2022 Jan 31;20(1):58
Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
Liang R, Tong X, Dong Z, Qin W, Fan L, Bai Z, Zhang Z, Xiang T, Wang Z, Tan N
Journal of ethnopharmacology 2022 Jan 30;283:114664
Journal of ethnopharmacology 2022 Jan 30;283:114664
RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80.
Tian Q, Gao H, Zhou Y, Zhu L, Yang J, Wang B, Liu P, Yang J
Cell death & disease 2022 Jan 21;13(1):71
Cell death & disease 2022 Jan 21;13(1):71
The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.
Popek M, Bobula B, Orzeł-Gajowik K, Zielińska M
International journal of molecular sciences 2022 Jan 19;23(3)
International journal of molecular sciences 2022 Jan 19;23(3)
Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
Shi S, Buck TM, Nickerson AJ, Brodsky JL, Kleyman TR
American journal of physiology. Cell physiology 2022 Jan 1;322(1):C111-C121
American journal of physiology. Cell physiology 2022 Jan 1;322(1):C111-C121
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability.
Zhang N, Shen Y, Li H, Chen Y, Zhang P, Lou S, Deng J
Experimental & molecular medicine 2022 Feb;54(2):194-205
Experimental & molecular medicine 2022 Feb;54(2):194-205
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X
The Journal of biological chemistry 2022 Feb;298(2):101561
The Journal of biological chemistry 2022 Feb;298(2):101561
Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification.
Guo Q, Zhang YC, Wang W, Wang YQ, Liu Y, Yang Z, Zhao MM, Feng N, Wang YH, Zhang XW, Yang H, Liu TT, Shi LY, Shi XM, Liu D, Tu PF, Zeng KW
Pharmacological research 2022 Feb;176:106046
Pharmacological research 2022 Feb;176:106046
Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition.
Mo S, Fang D, Zhao S, Thai Hoa PT, Zhou C, Liang T, He Y, Yu T, Chen Y, Qin W, Han Q, Su H, Zhu G, Luo X, Peng T, Han C
Annals of translational medicine 2022 Feb;10(3):151
Annals of translational medicine 2022 Feb;10(3):151
Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice.
Chen Y, Zhou Y, Li XC, Ma X, Mi WL, Chu YX, Wang YQ, Mao-Ying QL
Biological research 2022 Feb 3;55(1):5
Biological research 2022 Feb 3;55(1):5
Effects of the Water Extract of Fermented Rice Bran on Liver Damage and Intestinal Injury in Aged Rats with High-Fat Diet Feeding.
Chen TY, Chen YL, Chiu WC, Yeh CL, Tung YT, Shirakawa H, Liao WT, Yang SC
Plants (Basel, Switzerland) 2022 Feb 24;11(5)
Plants (Basel, Switzerland) 2022 Feb 24;11(5)
Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.
Tanishita Y, Sekiya H, Inohara N, Tsuchiya K, Mitsuyama M, Núñez G, Hara H
Cell reports 2022 Feb 22;38(8):110414
Cell reports 2022 Feb 22;38(8):110414
The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2.
Suthapot P, Xiao T, Felsenfeld G, Hongeng S, Wongtrakoongate P
Life sciences 2022 Feb 15;291:120298
Life sciences 2022 Feb 15;291:120298
Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.
Sen A, Prager BC, Zhong C, Park D, Zhu Z, Gimple RC, Wu Q, Bernatchez JA, Beck S, Clark AE, Siqueira-Neto JL, Rich JN, McVicker G
Cancer research 2022 Feb 1;82(3):377-390
Cancer research 2022 Feb 1;82(3):377-390
Hypoxic preconditioning promotes galvanotaxis of human dermal microvascular endothelial cells through NF-κB pathway.
Zhang Z, Wu C, Yang J, Liu J, Yi Li, Liu L, Kong M, Zhang J, Jiang X
Heliyon 2022 Dec;8(12):e12421
Heliyon 2022 Dec;8(12):e12421
Selective targeting of visceral adiposity by polycation nanomedicine.
Wan Q, Huang B, Li T, Xiao Y, He Y, Du W, Wang BZ, Dakin GF, Rosenbaum M, Goncalves MD, Chen S, Leong KW, Qiang L
Nature nanotechnology 2022 Dec;17(12):1311-1321
Nature nanotechnology 2022 Dec;17(12):1311-1321
Single-cell transcriptional profiling reveals heterogeneity and developmental trajectories of Ewing sarcoma.
Hong B, Li Y, Yang R, Dai S, Zhan Y, Zhang WB, Dong R
Journal of cancer research and clinical oncology 2022 Dec;148(12):3267-3280
Journal of cancer research and clinical oncology 2022 Dec;148(12):3267-3280
Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR.
Wang R, Li S, Chen P, Yue X, Wang S, Gu Y, Yuan Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154435
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154435
VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.
Li J, Huang D, Lei B, Huang J, Yang L, Nie M, Su S, Zhao Q, Wang Y
eLife 2022 Dec 9;11
eLife 2022 Dec 9;11
Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.
Fan R, Jiang H, Hu Y, Xu Y, Zhou Y, Chen G, Liu Y, Yao Y, Qin W, Chen W, Huang F, Chen X
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):112-120
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):112-120
Genome-Wide Analysis of Circular RNAs Reveals circCHRNG Regulates Sheep Myoblast Proliferation via miR-133/SRF and MEF2A Axis.
Liu Y, Chen Q, Bao J, Pu Y, Han J, Zhao H, Ma Y, Zhao Q
International journal of molecular sciences 2022 Dec 16;23(24)
International journal of molecular sciences 2022 Dec 16;23(24)
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
Resveratrol activates the SIRT1/PGC-1 pathway in mice to improve synaptic-related cognitive impairment after TBI.
Yu D, Zhao XY, Meng QP, Teng D, Deng K, Lin N
Brain research 2022 Dec 1;1796:148109
Brain research 2022 Dec 1;1796:148109
The DEAD-box helicase DDX3x ameliorates non-alcoholic fatty liver disease via mTORC1 signalling pathway.
Liu P, Zhang Y, Tang C, Cen L, Chen Y, Li S, Chen X, Yu M, Zhang J, Zhang X, Zeng H, Xu C, Yu C
Liver international : official journal of the International Association for the Study of the Liver 2022 Aug;42(8):1793-1802
Liver international : official journal of the International Association for the Study of the Liver 2022 Aug;42(8):1793-1802
VEGF promotes tendon regeneration of aged rats by inhibiting adipogenic differentiation of tendon stem/progenitor cells and promoting vascularization.
Lai F, Wang J, Tang H, Huang P, Liu J, He G, Zhou M, Tao X, Tang K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22433
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22433
Spirulina phycocyanin extract and its active components suppress epithelial-mesenchymal transition process in endometrial cancer via targeting TGF-beta1/SMAD4 signaling pathway.
Chen HY, Chiang YF, Huang CY, Shieh TM, Kao C, Chang FK, Huang TC, Ali M, Chang HY, Hong YH, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113219
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113219
Rational Design and Optimization of m(6)A-RNA Demethylase FTO Inhibitors as Anticancer Agents.
Huff S, Kummetha IR, Zhang L, Wang L, Bray W, Yin J, Kelley V, Wang Y, Rana TM
Journal of medicinal chemistry 2022 Aug 25;65(16):10920-10937
Journal of medicinal chemistry 2022 Aug 25;65(16):10920-10937
Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.
Zhang Z, Ji C, Wang YN, Liu S, Wang M, Xu X, Zhang D
Cells 2022 Aug 17;11(16)
Cells 2022 Aug 17;11(16)
Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity.
Li Q, Zhong X, Yao W, Yu J, Wang C, Li Z, Lai S, Qu F, Fu X, Huang X, Zhang D, Liu Y, Li H
The Journal of biological chemistry 2022 Apr;298(4):101753
The Journal of biological chemistry 2022 Apr;298(4):101753
AKT serine/threonine kinase 2-mediated phosphorylation of fascin threonine 403 regulates esophageal cancer progression.
Zhang ZD, Wen B, Li DJ, Deng DX, Wu XD, Cheng YW, Liao LD, Long L, Dong G, Xu LY, Li EM
The international journal of biochemistry & cell biology 2022 Apr;145:106188
The international journal of biochemistry & cell biology 2022 Apr;145:106188
A functional PVA aerogel-based membrane obtaining sutureability through modified electrospinning technology and achieving promising anti-adhesion effect after cardiac surgery.
Jin D, Yang S, Wu S, Yin M, Kuang H
Bioactive materials 2022 Apr;10:355-366
Bioactive materials 2022 Apr;10:355-366
Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma.
Ganesa S, Sule A, Sundaram RK, Bindra RS
Scientific reports 2022 Apr 6;12(1):5827
Scientific reports 2022 Apr 6;12(1):5827
The Role of ATF3 in Neuronal Differentiation and Development of Neuronal Networks in Opossum Postnatal Cortical Cultures.
Petrović A, Ban J, Ivaničić M, Tomljanović I, Mladinic M
International journal of molecular sciences 2022 Apr 29;23(9)
International journal of molecular sciences 2022 Apr 29;23(9)
Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via TRIM21, leading to cell death and defective myogenesis.
Soliman HAN, Toso EA, Darwish IE, Ali SM, Kyba M
Cell death & disease 2022 Apr 25;13(4):405
Cell death & disease 2022 Apr 25;13(4):405
Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
Yang Y, Xiao Q, Yin J, Li C, Yu D, He Y, Yang Z, Wang G
Communications biology 2022 Apr 19;5(1):374
Communications biology 2022 Apr 19;5(1):374
Characteristics of the Gut Microbiome and IL-13/TGF-β1 Mediated Fibrosis in Post-Kasai Cholangitis of Biliary Atresia.
Meng L, Liu J, Wang J, Du M, Zhang S, Huang Y, Shen Z, Dong R, Chen G, Zheng S
Frontiers in pediatrics 2021;9:751204
Frontiers in pediatrics 2021;9:751204
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes.
Giordano I, Pirone L, Muratore V, Landaluze E, Pérez C, Lang V, Garde-Lapido E, Gonzalez-Lopez M, Barroso-Gomila O, Vertegaal ACO, Aransay AM, Rodriguez JA, Rodriguez MS, Sutherland JD, Barrio R
Frontiers in cell and developmental biology 2021;9:715868
Frontiers in cell and developmental biology 2021;9:715868
Development and Validation of a Ferroptosis-Related Gene Signature for Overall Survival Prediction in Lung Adenocarcinoma.
Tian Q, Zhou Y, Zhu L, Gao H, Yang J
Frontiers in cell and developmental biology 2021;9:684259
Frontiers in cell and developmental biology 2021;9:684259
WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells.
Li Y, Bhanja A, Upadhyaya A, Zhao X, Song W
Frontiers in cell and developmental biology 2021;9:646077
Frontiers in cell and developmental biology 2021;9:646077
Samm50 Promotes Hypertrophy by Regulating Pink1-Dependent Mitophagy Signaling in Neonatal Cardiomyocytes.
Xu R, Kang L, Wei S, Yang C, Fu Y, Ding Z, Zou Y
Frontiers in cardiovascular medicine 2021;8:748156
Frontiers in cardiovascular medicine 2021;8:748156
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Jin Y, Zhang M, Li M, Zhang H, Zhao L, Qian C, Li S, Zhang H, Gao M, Pan B, Li R, Wan X, Cao C
Frontiers in molecular biosciences 2021;8:725319
Frontiers in molecular biosciences 2021;8:725319
Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules.
Messerschmidt VL, Chintapula U, Kuriakose AE, Laboy S, Truong TTD, Kydd LA, Jaworski J, Pan Z, Sadek H, Nguyen KT, Lee J
Frontiers in cardiovascular medicine 2021;8:707897
Frontiers in cardiovascular medicine 2021;8:707897
Indoleamine-2,3-Dioxygenase Activates Wnt/β-Catenin Inducing Kidney Fibrosis after Acute Kidney Injury.
Pan B, Zhang H, Hong Y, Ma M, Wan X, Cao C
Gerontology 2021;67(5):611-619
Gerontology 2021;67(5):611-619
JNK Signaling Pathway Mediates Fluoride-Induced Upregulation of CK1α during Enamel Formation.
Yang Z, Shi G, Guo J, Zhou Y, Jia J
Caries research 2021;55(3):225-233
Caries research 2021;55(3):225-233
Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway.
You Z, He L, Yan N
Journal of healthcare engineering 2021;2021:6394514
Journal of healthcare engineering 2021;2021:6394514
miR-708 Negatively Regulates TNFα/IL-1β Signaling by Suppressing NF-κB and Arachidonic Acid Pathways.
Monteleone NJ, Lutz CS
Mediators of inflammation 2021;2021:5595520
Mediators of inflammation 2021;2021:5595520
Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells.
Ji R, Ma L, Chen X, Sun R, Zhang L, Saiyin H, Wei W
PloS one 2021;16(11):e0258204
PloS one 2021;16(11):e0258204
Valproic Acid Induces Autism-Like Synaptic and Behavioral Deficits by Disrupting Histone Acetylation of Prefrontal Cortex ALDH1A1 in Rats.
Liu H, Tan M, Cheng B, Wang S, Xiao L, Zhu J, Wu Q, Lai X, Zhang Q, Chen J, Li T
Frontiers in neuroscience 2021;15:641284
Frontiers in neuroscience 2021;15:641284
Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release.
Chen H, Dai Y, Cui J, Yin X, Feng W, Lv M, Song H
Drug design, development and therapy 2021;15:1691-1704
Drug design, development and therapy 2021;15:1691-1704
Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease.
Tian Y, He M, Pan L, Yuan X, Xiong M, Meng L, Yao Z, Yu Z, Ye K, Zhang Z
Frontiers in aging neuroscience 2021;13:760781
Frontiers in aging neuroscience 2021;13:760781
Bifidobacterium infantis Maintains Genome Stability in Ulcerative Colitis via Regulating Anaphase-Promoting Complex Subunit 7.
Han T, Hu X, Li K, Zhang D, Zhang Y, Li J
Frontiers in microbiology 2021;12:761113
Frontiers in microbiology 2021;12:761113
Downregulation of SLC27A6 by DNA Hypermethylation Promotes Proliferation but Suppresses Metastasis of Nasopharyngeal Carcinoma Through Modulating Lipid Metabolism.
Zhong X, Yang Y, Li B, Liang P, Huang Y, Zheng Q, Wang Y, Xiao X, Mo Y, Zhang Z, Zhou X, Huang G, Zhao W
Frontiers in oncology 2021;11:780410
Frontiers in oncology 2021;11:780410
TAZ maintains telomere length in TNBC cells by mediating Rad51C expression.
Yang L, Wang B, Jiao X, Zhou C, Chen S, Gao X, Sun W, Song S, Li J, Liu J, Wang Y, Liu P
Breast cancer research : BCR 2021 Sep 6;23(1):89
Breast cancer research : BCR 2021 Sep 6;23(1):89
PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
Cheng YW, Zhang ZB, Lan BD, Lin JR, Chen XH, Kong LR, Xu L, Ruan CC, Gao PJ
The Journal of experimental medicine 2021 Sep 6;218(9)
The Journal of experimental medicine 2021 Sep 6;218(9)
Discovery of Potent Antiallergic Agents Based on an o-Aminopyridinyl Alkynyl Scaffold.
Xie Z, Xiang C, Li X, Fan C, Chen T, Liu M, Ma Y, Bai F, Tang W, Hu Y
Journal of medicinal chemistry 2021 Sep 23;64(18):13588-13603
Journal of medicinal chemistry 2021 Sep 23;64(18):13588-13603
HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1.
Zhang Q, Kang Y, Wang S, Gonzalez GM, Li W, Hui H, Wang Y, Rana TM
Nature communications 2021 Sep 20;12(1):5543
Nature communications 2021 Sep 20;12(1):5543
PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma.
Xia T, Liu M, Zhao Q, Ouyang J, Xu P, Chen B
Cell death & disease 2021 Sep 16;12(10):851
Cell death & disease 2021 Sep 16;12(10):851
A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
Yu S, Lu Y, Su A, Chen J, Li J, Zhou B, Liu X, Xia Q, Li Y, Li J, Huang M, Ye Y, Zhao Q, Jiang S, Yan X, Wang X, Di C, Pan J, Su S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Oct;8(19):e2101848
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Oct;8(19):e2101848
IKKε knockout alleviates angiotensin II-induced apoptosis and excessive autophagy in vascular smooth muscle cells by regulating the ERK1/2 pathway.
Chen G, Xu Y, Yao Y, Cao Y, Liu Y, Chai H, Chen W, Chen X
Experimental and therapeutic medicine 2021 Oct;22(4):1051
Experimental and therapeutic medicine 2021 Oct;22(4):1051
Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets.
Wang D, Pan D, Xie B, Wang S, Xing X, Liu X, Ma Y, Andersson L, Wu J, Jiang L
PLoS genetics 2021 Oct;17(10):e1009862
PLoS genetics 2021 Oct;17(10):e1009862
Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.
Kwok HH, Gao B, Chan KH, Ip MS, Minna JD, Lam DC
Cancers 2021 Oct 25;13(21)
Cancers 2021 Oct 25;13(21)
Disrupting RhoA activity by blocking Arhgef3 expression mitigates microglia-induced neuroinflammation post spinal cord contusion.
Liao L, Qian ZY, Li XY, Yang DS, Lei BJ, Li HJ, Hong X
Journal of neuroimmunology 2021 Oct 15;359:577688
Journal of neuroimmunology 2021 Oct 15;359:577688
Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss.
Jian B, Pang J, Xiong H, Zhang W, Zhan T, Su Z, Lin H, Zhang H, He W, Zheng Y
Toxicology letters 2021 Oct 10;350:249-260
Toxicology letters 2021 Oct 10;350:249-260
Effect of Metformin and Simvastatin in Inhibiting Proadipogenic Transcription Factors.
Jakab J, Zjalić M, Mikšić Š, Tušek I, Ćosić V, Volarić N, Nakić D, Včev A, Miškić B
Current issues in molecular biology 2021 Nov 25;43(3):2082-2097
Current issues in molecular biology 2021 Nov 25;43(3):2082-2097
Effects of aging on the histology and biochemistry of rat tendon healing.
Lai F, Tang H, Wang J, Lu K, Bian X, Wang Y, Shi Y, Guo Y, He G, Zhou M, Zhang X, Zhou B, Zhang J, Chen W, Tang K
BMC musculoskeletal disorders 2021 Nov 15;22(1):949
BMC musculoskeletal disorders 2021 Nov 15;22(1):949
11βHSD2 Efficacy in Preventing Transcriptional Activation of the Mineralocorticoid Receptor by Corticosterone.
Ali Y, Kuppusamy M, Velarde-Miranda C, Gomez-Sanchez CM, Plonczynski M, Gomez-Sanchez CE, Gomez-Sanchez EP
Journal of the Endocrine Society 2021 Nov 1;5(11):bvab146
Journal of the Endocrine Society 2021 Nov 1;5(11):bvab146
HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production.
Wang J, Chen Y, Zeng Z, Feng R, Wang Q, Zhang Q, Sun K, Chen AF, Lu Y, Yu Y
Experimental cell research 2021 Nov 1;408(1):112831
Experimental cell research 2021 Nov 1;408(1):112831
Fzd7/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer.
Zhang Z, Xu Y, Zhao C
Cancer medicine 2021 May;10(10):3332-3345
Cancer medicine 2021 May;10(10):3332-3345
Silencing TAK1 reduces MAPKs-MMP2/9 expression to reduce inflammation-driven neurohistological disruption post spinal cord injury.
Jiang S, Wu Y, Wu S, Ye S, Kong R, Chang J, Xia M, Bao J, Peng X, Hong X, Qian Z, Li H
Cell death discovery 2021 May 8;7(1):96
Cell death discovery 2021 May 8;7(1):96
Highly Conserved C-Terminal Region of Indian Hedgehog N-Fragment Contributes to Its Auto-Processing and Multimer Formation.
Wang X, Liu H, Liu Y, Han G, Wang Y, Chen H, He L, Ma G
Biomolecules 2021 May 25;11(6)
Biomolecules 2021 May 25;11(6)
Analyses of key mRNAs and lncRNAs for different osteo-differentiation potentials of periodontal ligament stem cell and gingival mesenchymal stem cell.
Jia L, Zhang Y, Li D, Zhang W, Zhang D, Xu X
Journal of cellular and molecular medicine 2021 May 24;25(13):6217-31
Journal of cellular and molecular medicine 2021 May 24;25(13):6217-31
EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function.
Bahl S, Ling H, Acharige NPN, Santos-Barriopedro I, Pflum MKH, Seto E
Cell death & disease 2021 May 11;12(5):469
Cell death & disease 2021 May 11;12(5):469
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
Qin W, Tong X, Liang R, Tang K, Wu X, Jia Y, Tan N
Journal of ethnopharmacology 2021 May 10;271:113827
Journal of ethnopharmacology 2021 May 10;271:113827
TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.
Ma M, Shi F, Zhai R, Wang H, Li K, Xu C, Yao W, Zhou F
Molecular biology reports 2021 Mar;48(3):2365-2375
Molecular biology reports 2021 Mar;48(3):2365-2375
Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation.
Heck AL, Mishra S, Prenzel T, Feulner L, Achhammer E, Särchen V, Blagg BSJ, Schneider-Brachert W, Schütze S, Fritsch J
Immunobiology 2021 Mar;226(2):152070
Immunobiology 2021 Mar;226(2):152070
Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis.
Li Y, Zeng X, Lu D, Yin M, Shan M, Gao Y
Human reproduction (Oxford, England) 2021 Mar 18;36(4):951-964
Human reproduction (Oxford, England) 2021 Mar 18;36(4):951-964
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA
Acta neuropathologica communications 2021 Mar 12;9(1):41
Acta neuropathologica communications 2021 Mar 12;9(1):41
Mitochondrial activity regulates the differentiation of skin-derived mesenchymal stem cells into brown adipocytes to contribute to hypertension.
Xi W, Chen W, Sun W, Li X, Suo Z, Jiang G, Gao P, Li Q
Stem cell research & therapy 2021 Mar 10;12(1):167
Stem cell research & therapy 2021 Mar 10;12(1):167
Development and Validation of High-Content Analysis for Screening HDAC6-Selective Inhibitors.
Nong Y, Hou Y, Pu Y, Li S, Lan Y
SLAS discovery : advancing life sciences R & D 2021 Jun;26(5):628-641
SLAS discovery : advancing life sciences R & D 2021 Jun;26(5):628-641
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.
Yi JS, Sias-Garcia O, Nasholm N, Hu X, Iniguez AB, Hall MD, Davis M, Guha R, Moreno-Smith M, Barbieri E, Duong K, Koach J, Qi J, Bradner JE, Stegmaier K, Weiss WA, Gustafson WC
Neoplasia (New York, N.Y.) 2021 Jun;23(6):624-633
Neoplasia (New York, N.Y.) 2021 Jun;23(6):624-633
A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer.
Liu X, Hu Q, Wang W, Ma H, Pu J, Cui J, Gong T, Wu Y, Lu W, Huang J
Biochemical pharmacology 2021 Jun;188:114583
Biochemical pharmacology 2021 Jun;188:114583
An Ultra-Stable, Oxygen-Supply Nanoprobe Emitting in Near-Infrared-II Window to Guide and Enhance Radiotherapy by Promoting Anti-Tumor Immunity.
Wang M, Li H, Huang B, Chen S, Cui R, Sun ZJ, Zhang M, Sun T
Advanced healthcare materials 2021 Jun;10(12):e2100090
Advanced healthcare materials 2021 Jun;10(12):e2100090
WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression.
Wu M, Xia X, Hu J, Fowlkes NW, Li S
Nature communications 2021 Jun 9;12(1):3500
Nature communications 2021 Jun 9;12(1):3500
Downregulation of Prolactin-Induced Protein Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells.
Li X, Zhang Y, Jia L, Xing Y, Zhao B, Sui L, Liu D, Xu X
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 7;27:e930610
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 7;27:e930610
A single amino acid substitution in PRKDC is a determinant of sensitivity to Adriamycin-induced renal injury in mouse.
Watanabe M, Takahashi Y, Hiura K, Nakano K, Okamura T, Sasaki H, Sasaki N
Biochemical and biophysical research communications 2021 Jun 4;556:121-126
Biochemical and biophysical research communications 2021 Jun 4;556:121-126
Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure.
Milewski K, Czarnecka AM, Albrecht J, Zielińska M
International journal of molecular sciences 2021 Jun 22;22(13)
International journal of molecular sciences 2021 Jun 22;22(13)
Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.
Li F, Li J, Yu J, Pan T, Yu B, Sang Q, Dai W, Hou J, Yan C, Zang M, Zhu Z, Su L, Li YY, Liu B
EBioMedicine 2021 Jul;69:103436
EBioMedicine 2021 Jul;69:103436
DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells.
Qi Z, Zhang Y, Yao K, Zhang M, Xu Y, Zhang J, Bai X, Zu H
Neurochemical research 2021 Jul;46(7):1627-1640
Neurochemical research 2021 Jul;46(7):1627-1640
The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer.
Wang JZ, Zhu W, Han J, Yang X, Zhou R, Lu HC, Yu H, Yuan WB, Li PC, Tao J, Lu Q, Wei JF, Yang H
Cancer communications (London, England) 2021 Jul;41(7):560-575
Cancer communications (London, England) 2021 Jul;41(7):560-575
Perturbation of astroglial Slc38 glutamine transporters by NH(4)(+) contributes to neurophysiologic manifestations in acute liver failure.
Hamdani EH, Popek M, Frontczak-Baniewicz M, Utheim TP, Albrecht J, Zielińska M, Chaudhry FA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jul;35(7):e21588
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jul;35(7):e21588
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.
Huang D, Chen X, Zeng X, Lao L, Li J, Xing Y, Lu Y, Ouyang Q, Chen J, Yang L, Su F, Yao H, Liu Q, Su S, Song E
Nature immunology 2021 Jul;22(7):865-879
Nature immunology 2021 Jul;22(7):865-879
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.
Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, Adachi K, Xia G, Yun K, Sarkar P, Ashizawa T
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):1710-1728
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):1710-1728
Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways.
Hu Y, Jing J, Shi Y, Zhang P, Dong D, Wu Y, Dong X, Li E, Fan Y
Translational cancer research 2021 Jul;10(7):3306-3316
Translational cancer research 2021 Jul;10(7):3306-3316
Rice Husk Silica Liquid Protects Pancreatic β Cells from Streptozotocin-Induced Oxidative Damage.
Chen HY, Chiang YF, Wang KL, Huang TC, Ali M, Shieh TM, Chang HY, Hong YH, Hsia SM
Antioxidants (Basel, Switzerland) 2021 Jul 5;10(7)
Antioxidants (Basel, Switzerland) 2021 Jul 5;10(7)
Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE).
Chen HY, Cheng WP, Chiang YF, Hong YH, Ali M, Huang TC, Wang KL, Shieh TM, Chang HY, Hsia SM
International journal of molecular sciences 2021 Jul 31;22(15)
International journal of molecular sciences 2021 Jul 31;22(15)
Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human.
Chijimatsu R, Miwa S, Okamura G, Miyahara J, Tachibana N, Ishikura H, Higuchi J, Maenohara Y, Tsuji S, Sameshima S, Takagi K, Nakazato K, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Tanaka S, Saito T
Stem cell research & therapy 2021 Jul 15;12(1):405
Stem cell research & therapy 2021 Jul 15;12(1):405
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.
Chen H, Qian Z, Zhang S, Tang J, Fang L, Jiang F, Ge D, Chang J, Cao J, Yang L, Cao X
Redox biology 2021 Jan;38:101774
Redox biology 2021 Jan;38:101774
Regulation of ABCG2 expression by Wnt5a through FZD7 in human pancreatic cancer cells.
Zhang Z, Gao S, Xu Y, Zhao C
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
Citrate regulates extracellular matrix mineralization during osteoblast differentiation in vitro.
Wu X, Dai H, Yu S, Zhao Y, Long Y, Li W, Tu J
Journal of inorganic biochemistry 2021 Jan;214:111269
Journal of inorganic biochemistry 2021 Jan;214:111269
Defining the protein and lipid constituents of tubular recycling endosomes.
Farmer T, Xie S, Naslavsky N, Stöckli J, James DE, Caplan S
The Journal of biological chemistry 2021 Jan-Jun;296:100190
The Journal of biological chemistry 2021 Jan-Jun;296:100190
GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
Xia Z, Zhang X, Liu P, Zhang R, Huang Z, Li D, Xiao X, Wu M, Ning N, Zhang Q, Zhang J, Liu M, Jiao B, Ren R
Cell death & disease 2021 Jan 9;12(1):54
Cell death & disease 2021 Jan 9;12(1):54
Lipolytic gene DAGLA is targeted by miR-223 in chicken hepatocytes.
Wang X, Li Y, Qu L, Guo J, Dou T, Hu Y, Ma M, Wang K
Gene 2021 Jan 30;767:145184
Gene 2021 Jan 30;767:145184
Functional constipation induces bladder overactivity associated with upregulations of Htr2 and Trpv2 pathways.
Iguchi N, Carrasco A Jr, Xie AX, Pineda RH, Malykhina AP, Wilcox DT
Scientific reports 2021 Jan 13;11(1):1149
Scientific reports 2021 Jan 13;11(1):1149
Maternal vitamin A deficiency impairs cholinergic and nitrergic neurons, leading to gastrointestinal dysfunction in rat offspring via RARβ.
Tan M, Yang T, Liu H, Xiao L, Li C, Zhu J, Chen J, Li T
Life sciences 2021 Jan 1;264:118688
Life sciences 2021 Jan 1;264:118688
Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model.
Smeltzer S, Quadri Z, Miller A, Zamudio F, Hunter J, Stewart NJF, Saji S, Lee DC, Chaput D, Selenica MB
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165939
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165939
Pyrvinium pamoate inhibits cell proliferation through ROS-mediated AKT-dependent signaling pathway in colorectal cancer.
Zheng W, Hu J, Lv Y, Bai B, Shan L, Chen K, Dai S, Zhu H
Medical oncology (Northwood, London, England) 2021 Feb 8;38(2):21
Medical oncology (Northwood, London, England) 2021 Feb 8;38(2):21
Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.
Davis RR, Li B, Yun SY, Chan A, Nareddy P, Gunawan S, Ayaz M, Lawrence HR, Reuther GW, Lawrence NJ, Schönbrunn E
Journal of medicinal chemistry 2021 Feb 25;64(4):2228-2241
Journal of medicinal chemistry 2021 Feb 25;64(4):2228-2241
Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors.
Zhang Y, Wang S, Wu Y, Hou W, Yuan L, Shen C, Wang J, Ye J, Zheng Q, Ma J, Xu J, Wei M, Li Z, Nian S, Xiong H, Zhang L, Shi Y, Fu B, Cao J, Yang C, Li Z, Yang T, Liu L, Yu H, Hu J, Ge S, Chen Y, Zhang T, Zhang J, Cheng T, Yuan Q, Xia N
Small methods 2021 Feb 15;5(2):2001031
Small methods 2021 Feb 15;5(2):2001031
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Pawlik MJ, Obara-Michlewska M, Popek MP, Czarnecka AM, Czuczwar SJ, Łuszczki J, Kołodziej M, Acewicz A, Wierzba-Bobrowicz T, Albrecht J
Brain research 2021 Feb 15;1753:147253
Brain research 2021 Feb 15;1753:147253
hsa‑miR‑429 targets CBX8 to promote cell apoptosis in diffuse large B‑cell lymphoma.
Liang Y, Yu ZJ, Liu M, Liu HM, Zhang JZ, Xiong T, Tang YY, Huang ZP
Molecular medicine reports 2021 Dec;24(6)
Molecular medicine reports 2021 Dec;24(6)
Halofuginone triggers a transcriptional program centered on ribosome biogenesis and function in honey bees.
Flores ME, McNamara-Bordewick NK, Lovinger NL, Snow JW
Insect biochemistry and molecular biology 2021 Dec;139:103667
Insect biochemistry and molecular biology 2021 Dec;139:103667
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600
Bioengineered 2021 Dec;12(1):589-600
Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.
Li H, Wang M, Huang B, Zhu SW, Zhou JJ, Chen DR, Cui R, Zhang M, Sun ZJ
Nature communications 2021 Dec 9;12(1):7149
Nature communications 2021 Dec 9;12(1):7149
TTP protects against acute liver failure by regulating CCL2 and CCL5 through m6A RNA methylation.
Xiao P, Li M, Zhou M, Zhao X, Wang C, Qiu J, Fang Q, Jiang H, Dong H, Zhou R
JCI insight 2021 Dec 8;6(23)
JCI insight 2021 Dec 8;6(23)
Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
Wu Y, Qi Y, Qiu Z, Chen W
Biochemical and biophysical research communications 2021 Dec 3;581:81-88
Biochemical and biophysical research communications 2021 Dec 3;581:81-88
The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells.
Shamloul A, Steinemann G, Roos K, Liem CH, Bernd J, Braun T, Zakrzewicz A, Berkholz J
Cells 2021 Dec 13;10(12)
Cells 2021 Dec 13;10(12)
Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.
Jaumotte JD, Franks AL, Bargerstock EM, Kisanga EP, Menden HL, Ghersi A, Omar M, Wang L, Rudine A, Short KL, Silswal N, Cole TJ, Sampath V, Monaghan-Nichols AP, DeFranco DB
Neurobiology of disease 2021 Aug;156:105422
Neurobiology of disease 2021 Aug;156:105422
Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma.
Ma X, Yang S, Jiang H, Wang Y, Xiang Z
Journal of translational medicine 2021 Aug 26;19(1):368
Journal of translational medicine 2021 Aug 26;19(1):368
2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.
Zhao Y, He L, Wang T, Zhu L, Yan N
Metabolites 2021 Aug 23;11(8)
Metabolites 2021 Aug 23;11(8)
HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity.
Chai Q, Li S, Collins MK, Li R, Ahmad I, Johnson SF, Frabutt DA, Yang Z, Shen X, Sun L, Hu J, Hultquist JF, Peterlin BM, Zheng YH
Cell reports 2021 Aug 10;36(6):109514
Cell reports 2021 Aug 10;36(6):109514
The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer.
Liu J, Lao L, Chen J, Li J, Zeng W, Zhu X, Li J, Chen X, Yang L, Xing Y, Chen F, Huang D, Zhang X, Wei W, Gong C, Huang S, Yu Z, Li Z, Yang L, Liu J, Liu X, Zheng Q, Meng X, Liang J, Sun L, Zeng M, Li M, Liu Q, Su S, Song E
Nature cancer 2021 Apr;2(4):457-473
Nature cancer 2021 Apr;2(4):457-473
Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors.
Crean-Tate KK, Braley C, Dey G, Esakov E, Saygin C, Trestan A, Silver DJ, Turaga SM, Connor EV, DeBernardo R, Michener CM, Rose PG, Lathia J, Reizes O
Journal of ovarian research 2021 Apr 22;14(1):55
Journal of ovarian research 2021 Apr 22;14(1):55
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer.
Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF
Nature communications 2021 Apr 15;12(1):2259
Nature communications 2021 Apr 15;12(1):2259
The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma.
Lipchick BC, Utley A, Han Z, Moparthy S, Yun DH, Bianchi-Smiraglia A, Wolff DW, Fink E, Liu L, Furdui CM, Lee J, Lee KP, Nikiforov MA
Blood advances 2021 Apr 13;5(7):1933-1946
Blood advances 2021 Apr 13;5(7):1933-1946
Oct4 Regulates the Transition of Cancer Stem-Like Cells to Tumor Endothelial-Like Cells in Human Liver Cancer.
Liu HL, Tang HT, Yang HL, Deng TT, Xu YP, Xu SQ, Peng L, Wang Z, Fang Q, Kuang XY, Li QS
Frontiers in cell and developmental biology 2020;8:563316
Frontiers in cell and developmental biology 2020;8:563316
miR-3 Encoded by Hepatitis B Virus Downregulates PTEN Protein Expression and Promotes Cell Proliferation.
Tang J, Xiao X, Jiang Y, Tian Y, Peng Z, Yang M, Xu Z, Gong G
Journal of hepatocellular carcinoma 2020;7:257-269
Journal of hepatocellular carcinoma 2020;7:257-269
Electric field down-regulates CD9 to promote keratinocytes migration through AMPK pathway.
Ji R, Teng M, Zhang Z, Wang W, Zhang Q, Lv Y, Zhang J, Jiang X
International journal of medical sciences 2020;17(7):865-873
International journal of medical sciences 2020;17(7):865-873
LRG1 promotes corneal angiogenesis and lymphangiogenesis in a corneal alkali burn mouse model.
Song S, Cheng J, Yu BJ, Zhou L, Xu HF, Yang LL
International journal of ophthalmology 2020;13(3):365-373
International journal of ophthalmology 2020;13(3):365-373
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.
Fan Y, Ma K, Jing J, Wang C, Hu Y, Shi Y, Li E, Geng Q
Journal of Cancer 2020;11(1):25-40
Journal of Cancer 2020;11(1):25-40
Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model.
Gu T, Zhao S, Jin G, Song M, Zhi Y, Zhao R, Ma F, Zheng Y, Wang K, Liu H, Xin M, Han W, Li X, Dong CD, Liu K, Dong Z
Frontiers in immunology 2020;11:621441
Frontiers in immunology 2020;11:621441
Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis.
Xie Z, Lu H, Yang S, Zeng Y, Li W, Wang L, Luo G, Fang F, Zeng T, Cheng W
Frontiers in pharmacology 2020;11:568423
Frontiers in pharmacology 2020;11:568423
Total Glycosides of Cistanche deserticola Promote Neurological Function Recovery by Inducing Neurovascular Regeneration via Nrf-2/Keap-1 Pathway in MCAO/R Rats.
Wang F, Li R, Tu P, Chen J, Zeng K, Jiang Y
Frontiers in pharmacology 2020;11:236
Frontiers in pharmacology 2020;11:236
LncRNA CSMD1-1 promotes the progression of Hepatocellular Carcinoma by activating MYC signaling.
Liu J, Xu R, Mai SJ, Ma YS, Zhang MY, Cao PS, Weng NQ, Wang RQ, Cao D, Wei W, Guo RP, Zhang YJ, Xu L, Chen MS, Zhang HZ, Huang L, Fu D, Wang HY
Theranostics 2020;10(17):7527-7544
Theranostics 2020;10(17):7527-7544
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/β-Catenin Signaling Pathway.
Liu D, Song Z, Wang X, Ouyang L
Frontiers in oncology 2020;10:865
Frontiers in oncology 2020;10:865
Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria.
Ren YZ, Zhang BZ, Zhao XJ, Zhang ZY
Journal of neurochemistry 2020 Sep;154(5):530-546
Journal of neurochemistry 2020 Sep;154(5):530-546
Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy via Suppression of Atrogin-1.
Miyawaki A, Rojasawasthien T, Hitomi S, Aoki Y, Urata M, Inoue A, Matsubara T, Morikawa K, Habu M, Tominaga K, Kokabu S
In vivo (Athens, Greece) 2020 Sep-Oct;34(5):2345-2351
In vivo (Athens, Greece) 2020 Sep-Oct;34(5):2345-2351
FAM122A Inhibits Erythroid Differentiation through GATA1.
Chen J, Zhou Q, Liu MH, Yang YS, Wang YQ, Huang Y, Chen GQ
Stem cell reports 2020 Sep 8;15(3):721-734
Stem cell reports 2020 Sep 8;15(3):721-734
Non-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1.
Yin P, Bai Y, Wang Z, Sun Y, Gao J, Na L, Zhang Z, Wang W, Zhao C
Cell communication and signaling : CCS 2020 Sep 7;18(1):143
Cell communication and signaling : CCS 2020 Sep 7;18(1):143
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Chen DB, Xie XW, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Fei R, Qin WY, Wang JH, Wu X, Shao QX, Wei L, Chen HS
Scientific reports 2020 Sep 3;10(1):14538
Scientific reports 2020 Sep 3;10(1):14538
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
Li H, Che J, Jiang M, Cui M, Feng G, Dong J, Zhang S, Lu L, Liu W, Fan S
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
High salt diet may promote progression of breast tumor through eliciting immune response.
Chen J, Liu X, Huang H, Zhang F, Lu Y, Hu H
International immunopharmacology 2020 Oct;87:106816
International immunopharmacology 2020 Oct;87:106816
Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.
Hamamoto Y, Ouhara K, Munenaga S, Shoji M, Ozawa T, Hisatsune J, Kado I, Kajiya M, Matsuda S, Kawai T, Mizuno N, Fujita T, Hirata S, Tanimoto K, Nakayama K, Kishi H, Sugiyama E, Kurihara H
Arthritis research & therapy 2020 Oct 19;22(1):249
Arthritis research & therapy 2020 Oct 19;22(1):249
Physiology and Morphological Correlates of Excitatory Transmission are Preserved in Glutamine Transporter SN1-Depleted Mouse Frontal Cortex.
Popek M, Bobula B, Sowa J, Hess G, Frontczak-Baniewicz M, Albrecht J, Zielińska M
Neuroscience 2020 Oct 15;446:124-136
Neuroscience 2020 Oct 15;446:124-136
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514
The EMBO journal 2020 Oct 15;39(20):e104514
AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.
Zhao W, Shi CS, Harrison K, Hwang IY, Nabar NR, Wang M, Kehrl JH
Journal of immunology (Baltimore, Md. : 1950) 2020 Oct 15;205(8):2255-2264
Journal of immunology (Baltimore, Md. : 1950) 2020 Oct 15;205(8):2255-2264
Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy.
Shirakawa T, Miyawaki A, Matsubara T, Okumura N, Okamoto H, Nakai N, Rojasawasthien T, Morikawa K, Inoue A, Goto A, Washio A, Tsujisawa T, Kawamoto T, Kokabu S
Nutrients 2020 Oct 11;12(10)
Nutrients 2020 Oct 11;12(10)
Endoplasmic Reticulum Stress Affects Cholesterol Homeostasis by Inhibiting LXRα Expression in Hepatocytes and Macrophages.
Wang T, Zhao Y, You Z, Li X, Xiong M, Li H, Yan N
Nutrients 2020 Oct 11;12(10)
Nutrients 2020 Oct 11;12(10)
The beneficial effect of oyster peptides and oyster powder on cyclophosphamide-induced reproductive impairment in male rats: A comparative study.
Li M, Zhou M, Wei Y, Jia F, Yan Y, Zhang R, Cai M, Gu R
Journal of food biochemistry 2020 Nov;44(11):e13468
Journal of food biochemistry 2020 Nov;44(11):e13468
Suppressor of Ty 16 promotes lung cancer malignancy and is negatively regulated by miR-1227-5p.
Yang L, Wang X, Jiao X, Tian B, Zhang M, Zhou C, Wang R, Chen H, Wang B, Li J, Liu J, Zhang G, Liu P
Cancer science 2020 Nov;111(11):4075-4087
Cancer science 2020 Nov;111(11):4075-4087
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum MA, Mack SC, Chavez L, Perry A, Raleigh DR, Rich JN
Cancer discovery 2020 Nov;10(11):1722-1741
Cancer discovery 2020 Nov;10(11):1722-1741
Magnesium Calcium Phosphate Cement Incorporating Citrate for Vascularized Bone Regeneration.
Wu X, Dai H, Yu S, Zhao Y, Long Y, Li W, Tu J
ACS biomaterials science & engineering 2020 Nov 9;6(11):6299-6308
ACS biomaterials science & engineering 2020 Nov 9;6(11):6299-6308
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.
Li L, Zhu S, Shu W, Guo Y, Guan Y, Zeng J, Wang H, Han L, Zhang J, Liu X, Li C, Hou X, Gao M, Ge J, Ren C, Zhang H, Schedl T, Guo X, Chen M, Wang Q
Molecular cell 2020 Nov 5;80(3):525-540.e9
Molecular cell 2020 Nov 5;80(3):525-540.e9
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer.
Shi Q, Li Y, Li S, Jin L, Lai H, Wu Y, Cai Z, Zhu M, Li Q, Li Y, Wang J, Liu Y, Wu Z, Song E, Liu Q
Nature communications 2020 Nov 2;11(1):5513
Nature communications 2020 Nov 2;11(1):5513
Knockout of mouse receptor accessory protein 6 leads to sperm function and morphology defects†.
Devlin DJ, Agrawal Zaneveld S, Nozawa K, Han X, Moye AR, Liang Q, Harnish JM, Matzuk MM, Chen R
Biology of reproduction 2020 May 26;102(6):1234-1247
Biology of reproduction 2020 May 26;102(6):1234-1247
Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA.
Dai H, Chen R, Gui C, Tao T, Ge Y, Zhao X, Qin R, Yao W, Gu S, Jiang Y, Gui J
Stem cell research & therapy 2020 May 25;11(1):199
Stem cell research & therapy 2020 May 25;11(1):199
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.
Wu X, Spence JS, Das T, Yuan X, Chen C, Zhang Y, Li Y, Sun Y, Chandran K, Hang HC, Peng T
Cell chemical biology 2020 May 21;27(5):571-585.e6
Cell chemical biology 2020 May 21;27(5):571-585.e6
Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles.
Taha EA, Sogawa C, Okusha Y, Kawai H, Oo MW, Elseoudi A, Lu Y, Nagatsuka H, Kubota S, Satoh A, Okamoto K, Eguchi T
Cancers 2020 May 16;12(5)
Cancers 2020 May 16;12(5)
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
Davenne T, Klintman J, Sharma S, Rigby RE, Blest HTW, Cursi C, Bridgeman A, Dadonaite B, De Keersmaecker K, Hillmen P, Chabes A, Schuh A, Rehwinkel J
Cell reports 2020 May 12;31(6):107640
Cell reports 2020 May 12;31(6):107640
Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage.
Izem L, Liu Y, Morton RE
Journal of lipid research 2020 Mar;61(3):422-431
Journal of lipid research 2020 Mar;61(3):422-431
HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism.
Lu L, Li H, Wu X, Rao J, Zhou J, Fan S, Shen Q
Cell proliferation 2020 Mar;53(3):e12777
Cell proliferation 2020 Mar;53(3):e12777
Generation of a DAPK1 knockout first (conditional ready) human embryonic stem cell line (ZSSYe001-A) by CRISPR-Cas9 technology.
Xu C, Zhou Z, Liu C, Kang X, Zhong X, Zhang Q, Xu Y
Stem cell research 2020 Mar;43:101693
Stem cell research 2020 Mar;43:101693
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Zhang ZH, He JQ, Zhao YY, Chen HC, Tan NH
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.
Dhawan K, Naslavsky N, Caplan S
The Journal of biological chemistry 2020 Mar 20;295(12):3837-3850
The Journal of biological chemistry 2020 Mar 20;295(12):3837-3850
Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity.
Lu Y, Zhao Q, Liao JY, Song E, Xia Q, Pan J, Li Y, Li J, Zhou B, Ye Y, Di C, Yu S, Zeng Y, Su S
Cell 2020 Mar 19;180(6):1081-1097.e24
Cell 2020 Mar 19;180(6):1081-1097.e24
Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade.
Lin X, Dinglin X, Cao S, Zheng S, Wu C, Chen W, Li Q, Hu Q, Zheng F, Wu Z, Lin DC, Yao Y, Xu X, Xie Z, Liu Q, Yao H, Hu H
Cell reports 2020 Jun 9;31(10):107753
Cell reports 2020 Jun 9;31(10):107753
Coagulation factor 2 thrombin receptor promotes malignancy in glioma under SOX2 regulation.
Gao G, Yang M, Wang F, Dang G, Zhang X, Zhao J, Wang X, Jin B
Aging 2020 Jun 7;12(11):10594—10613
Aging 2020 Jun 7;12(11):10594—10613
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
Monteleone NJ, Lutz CS
Oncotarget 2020 Jun 30;11(26):2464-2483
Oncotarget 2020 Jun 30;11(26):2464-2483
Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis.
Richter LR, Wan Q, Wen D, Zhang Y, Yu J, Kang JK, Zhu C, McKinnon EL, Gu Z, Qiang L, Pajvani UB
ACS nano 2020 Jun 23;14(6):6878-6886
ACS nano 2020 Jun 23;14(6):6878-6886
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E
Nature 2020 Jul;583(7814):133-138
Nature 2020 Jul;583(7814):133-138
Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway.
Xiong Y, Zhao B, Zhang W, Jia L, Zhang Y, Xu X
Iranian journal of basic medical sciences 2020 Jul;23(7):954-960
Iranian journal of basic medical sciences 2020 Jul;23(7):954-960
HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV.
Hock DH, Reljic B, Ang CS, Muellner-Wong L, Mountford HS, Compton AG, Ryan MT, Thorburn DR, Stroud DA
Molecular & cellular proteomics : MCP 2020 Jul;19(7):1145-1160
Molecular & cellular proteomics : MCP 2020 Jul;19(7):1145-1160
Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Wu Y, Zhao Y, He X, He Z, Wang T, Wan L, Chen L, Yan N
Molecular medicine reports 2020 Jan;21(1):249-257
Molecular medicine reports 2020 Jan;21(1):249-257
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer.
Wang Z, Xiang Z, Zhu T, Chen J, Zhong MZ, Huang J, Wang KS, Li L, Sun LQ, Zhou WB
Oncology letters 2020 Jan;19(1):167-176
Oncology letters 2020 Jan;19(1):167-176
Calcium Channel α2δ1 Subunit Mediates Secondary Orofacial Hyperalgesia Through PKC-TRPA1/Gap Junction Signaling.
Cui WQ, Chu YX, Xu F, Chen T, Gao L, Feng Y, Hu XM, Yang W, Du LX, Zhang WW, Mao-Ying QL, Mi WL, Wang YQ
The journal of pain 2020 Jan-Feb;21(1-2):238-257
The journal of pain 2020 Jan-Feb;21(1-2):238-257
Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.
Jia L, Xiong Y, Zhang W, Ma X, Xu X
Experimental cell research 2020 Jan 15;386(2):111717
Experimental cell research 2020 Jan 15;386(2):111717
Glibenclamide ameliorates transplant-induced arteriosclerosis and inhibits macrophage migration and MCP-1 expression.
Zou Y, Zhou C, Xu H, Yu J, Ye P, Zhang H, Chen S, Zhao J, Le S, Cui J, Jiang L, Wu J, Xia J
Life sciences 2020 Jan 15;241:117141
Life sciences 2020 Jan 15;241:117141
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.
Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, Chang X, Jin Z, Li J, Zhu Z, Liu B, Su L
Oncogene 2020 Feb;39(7):1414-1428
Oncogene 2020 Feb;39(7):1414-1428
Adenosine A(2A) receptor activation prevents DOCA-salt induced hypertensive cardiac remodeling via iBAT.
Zhou YP, Ruan CC, Kong LR, Gao PJ
Biochemical and biophysical research communications 2020 Feb 19;
Biochemical and biophysical research communications 2020 Feb 19;
Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway.
He Y, Fang X, Shi J, Li X, Xie M, Liu X
Chemico-biological interactions 2020 Feb 1;317:108942
Chemico-biological interactions 2020 Feb 1;317:108942
Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes.
Skowrońska K, Kozłowska H, Albrecht J
Cell calcium 2020 Dec;92:102304
Cell calcium 2020 Dec;92:102304
Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.
Gao M, Lu W, Shu Y, Yang Z, Sun S, Xu J, Gan S, Zhu S, Qiu G, Zhuo F, Xu S, Wang Y, Chen J, Wu X, Huang J
CNS neuroscience & therapeutics 2020 Dec;26(12):1288-1302
CNS neuroscience & therapeutics 2020 Dec;26(12):1288-1302
Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation.
Yu T, Wan F, Liu C, Zhang X, Liu Z, Zhang J, Xiong J, Wang T, Zhang Z
European journal of pharmacology 2020 Dec 5;888:173586
European journal of pharmacology 2020 Dec 5;888:173586
Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell carcinoma metastasis by regulating Snail.
Yuan F, Miao Z, Chen W, Wu F, Wei C, Yong J, Xiao C
Journal of biochemistry 2020 Dec 26;168(6):651-657
Journal of biochemistry 2020 Dec 26;168(6):651-657
PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.
Huang Z, Liu M, Li D, Tan Y, Zhang R, Xia Z, Wang P, Jiao B, Liu P, Ren R
The Journal of biological chemistry 2020 Dec 25;295(52):18343-18354
The Journal of biological chemistry 2020 Dec 25;295(52):18343-18354
miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells.
Monteleone NJ, Lutz CS
Oncotarget 2020 Dec 22;11(51):4699-4721
Oncotarget 2020 Dec 22;11(51):4699-4721
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.
Jin CY, Du L, Nuerlan AH, Wang XL, Yang YW, Guo R
Aging 2020 Dec 19;13(3):3518-3535
Aging 2020 Dec 19;13(3):3518-3535
Protocol for Site-Specific Photo-Crosslinking Proteomics to Identify Protein-Protein Interactions in Mammalian Cells.
Chen C, Peng T
STAR protocols 2020 Dec 18;1(3):100109
STAR protocols 2020 Dec 18;1(3):100109
PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment.
Liu L, Fan L, Chan M, Kraakman MJ, Yang J, Fan Y, Aaron N, Wan Q, Carrillo-Sepulveda MA, Tall AR, Tabas I, Accili D, Qiang L
Diabetes 2020 Aug;69(8):1793-1803
Diabetes 2020 Aug;69(8):1793-1803
Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
Chen X, Bao G, Liu F
Cellular and molecular neurobiology 2020 Aug;40(6):999-1010
Cellular and molecular neurobiology 2020 Aug;40(6):999-1010
TNF‑α treatment increases DKK1 protein levels in primary osteoblasts via upregulation of DKK1 mRNA levels and downregulation of miR‑335‑5p.
Li S, Yin Y, Yao L, Lin Z, Sun S, Zhang J, Li X
Molecular medicine reports 2020 Aug;22(2):1017-1025
Molecular medicine reports 2020 Aug;22(2):1017-1025
Downregulation of GPR183 on infection restricts the early infection and intracellular replication of mycobacterium tuberculosis in macrophage.
Tang J, Shi Y, Zhan L, Qin C
Microbial pathogenesis 2020 Aug;145:104234
Microbial pathogenesis 2020 Aug;145:104234
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Morgan SE, Schroten H, Ishikawa H, Zhao N
Brain sciences 2020 Aug 8;10(8)
Brain sciences 2020 Aug 8;10(8)
Hydroxysafflor yellow A induces autophagy in human liver cancer cells by regulating Beclin 1 and ERK expression.
Chen Z, Liu L, Liu Y, Wang S, Zhang S, Dong R, Xu M, Ma Y, Wang J, Zhang Q, Wei P
Experimental and therapeutic medicine 2020 Apr;19(4):2989-2996
Experimental and therapeutic medicine 2020 Apr;19(4):2989-2996
STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease.
Wang X, Rao H, Zhao J, Wee A, Li X, Fei R, Huang R, Wu C, Liu F, Wei L
Laboratory investigation; a journal of technical methods and pathology 2020 Apr;100(4):542-552
Laboratory investigation; a journal of technical methods and pathology 2020 Apr;100(4):542-552
Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer.
Okusha Y, Eguchi T, Tran MT, Sogawa C, Yoshida K, Itagaki M, Taha EA, Ono K, Aoyama E, Okamura H, Kozaki KI, Calderwood SK, Takigawa M, Okamoto K
Cancers 2020 Apr 4;12(4)
Cancers 2020 Apr 4;12(4)
EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation.
Zhang Y, Yang C, Ge S, Wang L, Zhang J, Yang P
BMC molecular and cell biology 2020 Apr 16;21(1):29
BMC molecular and cell biology 2020 Apr 16;21(1):29
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
Tian F, Wang Z, He J, Zhang Z, Tan N
European journal of pharmacology 2020 Apr 15;873:172989
European journal of pharmacology 2020 Apr 15;873:172989
Intravaginal Administration of Human Type III Collagen-Derived Biomaterial with High Cell-Adhesion Activity to Treat Vaginal Atrophy in Rats.
You S, Liu S, Dong X, Li H, Zhu Y, Hu L
ACS biomaterials science & engineering 2020 Apr 13;6(4):1977-1988
ACS biomaterials science & engineering 2020 Apr 13;6(4):1977-1988
Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel.
Shi S, Montalbetti N, Wang X, Rush BM, Marciszyn AL, Baty CJ, Tan RJ, Carattino MD, Kleyman TR
The Journal of biological chemistry 2020 Apr 10;295(15):4950-4962
The Journal of biological chemistry 2020 Apr 10;295(15):4950-4962
X-linked inhibitor of apoptosis protein accelerates migration by inducing epithelial-mesenchymal transition through TGF-β signaling pathway in esophageal cancer cells.
Jin Y, Lu X, Wang M, Zhao X, Xue L
Cell & bioscience 2019;9:76
Cell & bioscience 2019;9:76
Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development.
Pruski M, Hu L, Yang C, Wang Y, Zhang JB, Zhang L, Huang Y, Rajnicek AM, St Clair D, McCaig CD, Lang B, Ding YQ
Frontiers in cell and developmental biology 2019;7:287
Frontiers in cell and developmental biology 2019;7:287
Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL.
Shi CS, Kehrl JH
Cell death discovery 2019;5:151
Cell death discovery 2019;5:151
SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes.
Shi CS, Nabar NR, Huang NN, Kehrl JH
Cell death discovery 2019;5:101
Cell death discovery 2019;5:101
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.
Fan Y, Li M, Ma K, Hu Y, Jing J, Shi Y, Li E, Dong D
Cancer biology & therapy 2019;20(5):617-632
Cancer biology & therapy 2019;20(5):617-632
Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.
Horikoshi N, Sharma D, Leonard F, Pandita RK, Charaka VK, Hambarde S, Horikoshi NT, Gaur Khaitan P, Chakraborty S, Cote J, Godin B, Hunt CR, Pandita TK
Communications biology 2019;2:253
Communications biology 2019;2:253
CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17.
Liu J, Zhu G, Jia N, Wang W, Wang Y, Yin M, Jiang X, Huang Y, Zhang J
International journal of biological sciences 2019;15(2):493-506
International journal of biological sciences 2019;15(2):493-506
Long Noncoding RNA GAS5 Acts As A Tumor Suppressor In Laryngeal Squamous Cell Carcinoma Via miR-21.
Lyu K, Xu Y, Yue H, Li Y, Zhao J, Chen L, Wu J, Zhu X, Chai L, Li C, Wen W, Lei W
Cancer management and research 2019;11:8487-8498
Cancer management and research 2019;11:8487-8498
Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis.
Li H, Lu T, Sun W, Ma R, Zhong H, Wei Y, Chen D, Wen Y, Carlsten C, Wen W
Frontiers in immunology 2019;10:2271
Frontiers in immunology 2019;10:2271
Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion.
Tong X, Liang R, Jia Y, Qin W, Guo C, Wu X, Wang Z, Chen D, Tan N
Frontiers in pharmacology 2019;10:1422
Frontiers in pharmacology 2019;10:1422
A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.
Bosnakovski D, da Silva MT, Sunny ST, Ener ET, Toso EA, Yuan C, Cui Z, Walters MA, Jadhav A, Kyba M
Science advances 2019 Sep;5(9):eaaw7781
Science advances 2019 Sep;5(9):eaaw7781
Nicotinic acetylcholine receptor subunit expression in the gastrocnemius and in the orbicularis oris before and after facial nerve injury in rats.
Xu J, Huang Y, Li S, Chen L, Xue Z
Neurological research 2019 Sep;41(9):817-826
Neurological research 2019 Sep;41(9):817-826
Different signalling in infarcted and non-infarcted areas of rat failing hearts: A role of necroptosis and inflammation.
Lichý M, Szobi A, Hrdlička J, Horváth C, Kormanová V, Rajtík T, Neckář J, Kolář F, Adameová A
Journal of cellular and molecular medicine 2019 Sep;23(9):6429-6441
Journal of cellular and molecular medicine 2019 Sep;23(9):6429-6441
Potential roles of lncRNA-Cox2 and EGR1 in regulating epidural fibrosis following laminectomy.
Qian ZY, Jiang F, Tang J, Ge DW, Chen HT, Zheng SN, Cao XJ, Ge YB, Yang L
European review for medical and pharmacological sciences 2019 Sep;23(17):7191-7199
European review for medical and pharmacological sciences 2019 Sep;23(17):7191-7199
Regulation of the Metal Transporters ZIP14 and ZnT10 by Manganese Intake in Mice.
Felber DM, Wu Y, Zhao N
Nutrients 2019 Sep 4;11(9)
Nutrients 2019 Sep 4;11(9)
miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.
Xu X, Chen X, Xu M, Liu X, Pan B, Qin J, Xu T, Zeng K, Pan Y, He B, Sun H, Sun L, Wang S
Aging 2019 Sep 22;11(18):7357-7385
Aging 2019 Sep 22;11(18):7357-7385
Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress.
He Z, Du X, Wu Y, Hua L, Wan L, Yan N
International journal of molecular medicine 2019 Oct;44(4):1289-1298
International journal of molecular medicine 2019 Oct;44(4):1289-1298
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Zimmerman KA, Song CJ, Li Z, Lever JM, Crossman DK, Rains A, Aloria EJ, Gonzalez NM, Bassler JR, Zhou J, Crowley MR, Revell DZ, Yan Z, Shan D, Benveniste EN, George JF, Mrug M, Yoder BK
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1841-1856
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1841-1856
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, Wang Z, Tan N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109188
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109188
Increased miRNA-518b inhibits trophoblast migration and angiogenesis by targeting EGR1 in early embryonic arrest†.
Yang W, Lu Z, Zhi Z, Liu L, Deng L, Jiang X, Pang L
Biology of reproduction 2019 Oct 25;101(4):664-674
Biology of reproduction 2019 Oct 25;101(4):664-674
Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer.
Hu XM, Yang W, Du LX, Cui WQ, Mi WL, Mao-Ying QL, Chu YX, Wang YQ
Anesthesiology 2019 Nov;131(5):1125-1147
Anesthesiology 2019 Nov;131(5):1125-1147
Analyses of epithelial Na(+) channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating.
Wang X, Chen J, Shi S, Sheng S, Kleyman TR
The Journal of biological chemistry 2019 Nov 8;294(45):16765-16775
The Journal of biological chemistry 2019 Nov 8;294(45):16765-16775
Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.
Bellini A, Bessoltane-Bentahar N, Bhalshankar J, Clement N, Raynal V, Baulande S, Bernard V, Danzon A, Chicard M, Colmet-Daage L, Pierron G, Le Roux L, Planchon JM, Combaret V, Lapouble E, Corradini N, Thebaud E, Gambart M, Valteau-Couanet D, Michon J, Louis-Brennetot C, Janoueix-Lerosey I, Defachelles AS, Bourdeaut F, Delattre O, Schleiermacher G
International journal of cancer 2019 Nov 15;145(10):2781-2791
International journal of cancer 2019 Nov 15;145(10):2781-2791
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
Xie S, Farmer T, Naslavsky N, Caplan S
Journal of cell science 2019 Nov 14;132(22)
Journal of cell science 2019 Nov 14;132(22)
The mTOR-RUNX1 pathway regulates DC-SIGN expression in renal tubular epithelial cells.
Zhou S, Zhang L, Feng D, Luo M, Xie R, Yang K, Xu D, Yang K, Fei J, Zhou T
Biochemical and biophysical research communications 2019 Nov 12;519(3):620-625
Biochemical and biophysical research communications 2019 Nov 12;519(3):620-625
Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane.
Farmer T, O'Neill KL, Naslavsky N, Luo X, Caplan S
Molecular biology of the cell 2019 May 1;30(10):1138-1146
Molecular biology of the cell 2019 May 1;30(10):1138-1146
The role of ZBTB38 in promoting migration and invasive growth of bladder cancer cells.
Jing J, Liu J, Wang Y, Zhang M, Yang L, Shi F, Liu P, She J
Oncology reports 2019 Mar;41(3):1980-1990
Oncology reports 2019 Mar;41(3):1980-1990
Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration.
Zhang J, Zhang C, Jiang X, Li L, Zhang D, Tang D, Yan T, Zhang Q, Yuan H, Jia J, Hu J, Zhang J, Huang Y
Cell death & disease 2019 Mar 8;10(3):234
Cell death & disease 2019 Mar 8;10(3):234
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.
Liu J, Zhang X, Chen K, Cheng Y, Liu S, Xia M, Chen Y, Zhu H, Li Z, Cao X
Immunity 2019 Mar 19;50(3):600-615.e15
Immunity 2019 Mar 19;50(3):600-615.e15
Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop.
Wang Y, Chen J, Yang L, Li J, Wu W, Huang M, Lin L, Su S
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Mar 15;25(6):1957-1969
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Mar 15;25(6):1957-1969
Gα(i2) Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination.
Vural A, Nabar NR, Hwang IY, Sohn S, Park C, Karlsson MCI, Blumer JB, Kehrl JH
Journal of immunology (Baltimore, Md. : 1950) 2019 Mar 1;202(5):1510-1520
Journal of immunology (Baltimore, Md. : 1950) 2019 Mar 1;202(5):1510-1520
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
Scheiber IF, Wu Y, Morgan SE, Zhao N
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14.
Scheiber IF, Alarcon NO, Zhao N
Nutrients 2019 Jun 28;11(7)
Nutrients 2019 Jun 28;11(7)
Programmable RNA-Guided RNA Effector Proteins Built from Human Parts.
Rauch S, He E, Srienc M, Zhou H, Zhang Z, Dickinson BC
Cell 2019 Jun 27;178(1):122-134.e12
Cell 2019 Jun 27;178(1):122-134.e12
Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.
Hua L, Wu N, Zhao R, He X, Liu Q, Li X, He Z, Yu L, Yan N
International journal of molecular sciences 2019 Jun 12;20(12)
International journal of molecular sciences 2019 Jun 12;20(12)
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA
Molecular cell 2019 Jul 25;75(2):382-393.e5
Molecular cell 2019 Jul 25;75(2):382-393.e5
Thermoregulation via Temperature-Dependent PGD(2) Production in Mouse Preoptic Area.
Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY
Neuron 2019 Jul 17;103(2):309-322.e7
Neuron 2019 Jul 17;103(2):309-322.e7
MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.
Arifuzzaman M, Mobley YR, Choi HW, Bist P, Salinas CA, Brown ZD, Chen SL, Staats HF, Abraham SN
Science advances 2019 Jan;5(1):eaav0216
Science advances 2019 Jan;5(1):eaav0216
Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism.
Ji Y, Zhang P, Xing Y, Jia L, Zhang Y, Jia T, Wu X, Zhao B, Xu X
International journal of molecular medicine 2019 Jan;43(1):167-176
International journal of molecular medicine 2019 Jan;43(1):167-176
Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes.
Skowrońska K, Obara-Michlewska M, Czarnecka A, Dąbrowska K, Zielińska M, Albrecht J
Neurotoxicity research 2019 Jan;35(1):271-280
Neurotoxicity research 2019 Jan;35(1):271-280
Spinal Serotonin 1A Receptor Contributes to the Analgesia of Acupoint Catgut Embedding by Inhibiting Phosphorylation of the N-Methyl-d-Aspartate Receptor GluN1 Subunit in Complete Freund's Adjuvant-Induced Inflammatory Pain in Rats.
Cui WQ, Sun WS, Xu F, Hu XM, Yang W, Zhou Y, Du LX, Zhang WW, Mao-Ying QL, Mi WL, Chu YX, Wang YQ
The journal of pain 2019 Jan;20(1):16.e1-16.e16
The journal of pain 2019 Jan;20(1):16.e1-16.e16
Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition.
Mattoo AR, Joun A, Jessup JM
Molecular cancer research : MCR 2019 Jan;17(1):42-53
Molecular cancer research : MCR 2019 Jan;17(1):42-53
PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.
Lim V, Zhu H, Diao S, Hu L, Hu J
Biochemical and biophysical research communications 2019 Jan 8;508(2):646-653
Biochemical and biophysical research communications 2019 Jan 8;508(2):646-653
Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway.
Majewska E, Márquez J, Albrecht J, Szeliga M
Cancers 2019 Jan 19;11(1)
Cancers 2019 Jan 19;11(1)
Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells.
Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, Huang X, Liu Y, Wang J, Dougherty U, Bissonnette MB, Shen B, Weichselbaum RR, Xu MM, He C
Nature 2019 Feb;566(7743):270-274
Nature 2019 Feb;566(7743):270-274
Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs.
Wei DM, Jiang MT, Lin P, Yang H, Dang YW, Yu Q, Liao DY, Luo DZ, Chen G
International journal of oncology 2019 Feb;54(2):600-626
International journal of oncology 2019 Feb;54(2):600-626
MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.
Qu W, Wen X, Su K, Gou W
Journal of cellular and molecular medicine 2019 Feb;23(2):1541-1552
Journal of cellular and molecular medicine 2019 Feb;23(2):1541-1552
Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells.
Liu S, Hou H, Zhang P, Wu Y, He X, Li H, Yan N
Molecular medicine reports 2019 Feb;19(2):1159-1167
Molecular medicine reports 2019 Feb;19(2):1159-1167
Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.
Yang J, Zhang X, Chen Z, Shen Y, Wang F, Wang Y, Liu Y, Liu P, Yang J
Cell death & disease 2019 Feb 21;10(3):179
Cell death & disease 2019 Feb 21;10(3):179
Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.
He Y, Lin Y, Zhu Y, Ping P, Wang G, Sun F
Biology of reproduction 2019 Feb 1;100(2):561-572
Biology of reproduction 2019 Feb 1;100(2):561-572
Rutin promotes the formation and osteogenic differentiation of human periodontal ligament stem cell sheets in vitro.
Zhao B, Zhang Y, Xiong Y, Xu X
International journal of molecular medicine 2019 Dec;44(6):2289-2297
International journal of molecular medicine 2019 Dec;44(6):2289-2297
A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability.
Xia B, Hong T, He X, Hu X, Gao Y
Cell transplantation 2019 Dec;28(12):1614-1623
Cell transplantation 2019 Dec;28(12):1614-1623
Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery.
Wu N, Yuan Z, Du KY, Fang L, Lyu J, Zhang C, He A, Eshaghi E, Zeng K, Ma J, Du WW, Yang BB
Cell death and differentiation 2019 Dec;26(12):2758-2773
Cell death and differentiation 2019 Dec;26(12):2758-2773
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS
Nature immunology 2019 Dec;20(12):1644-1655
Nature immunology 2019 Dec;20(12):1644-1655
LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription.
Xiu B, Chi Y, Liu L, Chi W, Zhang Q, Chen J, Guo R, Si J, Li L, Xue J, Shao ZM, Wu ZH, Huang S, Wu J
Molecular cancer 2019 Dec 19;18(1):187
Molecular cancer 2019 Dec 19;18(1):187
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.
Chong KY, Kang M, Garofalo F, Ueno D, Liang H, Cady S, Madarikan O, Pitruzzello N, Tsai CH, Hartwich TMP, Shuch BM, Yang-Hartwich Y
Molecular pharmacology 2019 Aug;96(2):168-179
Molecular pharmacology 2019 Aug;96(2):168-179
Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA) Requires Death Receptor Fas, in Addition to LFA-1, To Trigger Cell Death in T Lymphocytes.
Vega BA, Schober LT, Kim T, Belinka BA Jr, Kachlany SC
Infection and immunity 2019 Aug;87(8)
Infection and immunity 2019 Aug;87(8)
Palmitoylation is required for TNF-R1 signaling.
Zingler P, Särchen V, Glatter T, Caning L, Saggau C, Kathayat RS, Dickinson BC, Adam D, Schneider-Brachert W, Schütze S, Fritsch J
Cell communication and signaling : CCS 2019 Aug 5;17(1):90
Cell communication and signaling : CCS 2019 Aug 5;17(1):90
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Fons NR, Sundaram RK, Breuer GA, Peng S, McLean RL, Kalathil AN, Schmidt MS, Carvalho DM, Mackay A, Jones C, Carcaboso ÁM, Nazarian J, Berens ME, Brenner C, Bindra RS
Nature communications 2019 Aug 22;10(1):3790
Nature communications 2019 Aug 22;10(1):3790
Mutations in topoisomerase IIβ result in a B cell immunodeficiency.
Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM
Nature communications 2019 Aug 13;10(1):3644
Nature communications 2019 Aug 13;10(1):3644
CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.
Li K, Meng Z, Jiang L, Xia C, Xu K, Yuan D, Chen H, Zhang B, Liu S
Molecular and cellular probes 2019 Apr;44:57-62
Molecular and cellular probes 2019 Apr;44:57-62
BP‑1‑102 exerts an antitumor effect on the AGS human gastric cancer cell line through modulating the STAT3 and MAPK signaling pathways.
Jiang X, Tang J, Wu M, Chen S, Xu Z, Wang H, Wang H, Yu X, Li Z, Teng L
Molecular medicine reports 2019 Apr;19(4):2698-2706
Molecular medicine reports 2019 Apr;19(4):2698-2706
Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production.
Kotredes KP, Razmpour R, Lutton E, Alfonso-Prieto M, Ramirez SH, Gamero AM
Oncotarget 2019 Apr 12;10(28):2675-2692
Oncotarget 2019 Apr 12;10(28):2675-2692
miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
Monteleone NJ, Moore AE, Iacona JR, Lutz CS, Dixon DA
Scientific reports 2019 Apr 1;9(1):5405
Scientific reports 2019 Apr 1;9(1):5405
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
Gou Y, Li X, Li P, Zhang H, Xu T, Wang H, Wang B, Ma X, Jiang X, Zhang Z
Human reproduction (Oxford, England) 2019 Apr 1;34(4):646-658
Human reproduction (Oxford, England) 2019 Apr 1;34(4):646-658
FEZF1 is an Independent Predictive Factor for Recurrence and Promotes Cell Proliferation and Migration in Cervical Cancer.
Lan Y, Xiao X, Luo Y, He Z, Song X
Journal of Cancer 2018;9(21):3929-3938
Journal of Cancer 2018;9(21):3929-3938
Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer.
Xiang Z, Huang X, Wang J, Zhang J, Ji J, Yan R, Zhu Z, Cai W, Yu Y
Frontiers in pharmacology 2018;9:861
Frontiers in pharmacology 2018;9:861
Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.
Li X, Qiu Z, Jin Q, Chen G, Guo M
Frontiers in pharmacology 2018;9:629
Frontiers in pharmacology 2018;9:629
Decrease of Perivascular Adipose Tissue Browning Is Associated With Vascular Dysfunction in Spontaneous Hypertensive Rats During Aging.
Kong LR, Zhou YP, Chen DR, Ruan CC, Gao PJ
Frontiers in physiology 2018;9:400
Frontiers in physiology 2018;9:400
Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A.
Zhou J, Zhang C, Zheng GH, Qiu Z
Evidence-based complementary and alternative medicine : eCAM 2018;2018:8478943
Evidence-based complementary and alternative medicine : eCAM 2018;2018:8478943
IMP/GTP balance modulates cytoophidium assembly and IMPDH activity.
Keppeke GD, Chang CC, Peng M, Chen LY, Lin WC, Pai LM, Andrade LEC, Sung LY, Liu JL
Cell division 2018;13:5
Cell division 2018;13:5
The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer.
Li J, Liu J, Li P, Zhou C, Liu P
Experimental biology and medicine (Maywood, N.J.) 2018 Sep;243(13):1066-1073
Experimental biology and medicine (Maywood, N.J.) 2018 Sep;243(13):1066-1073
m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Liu J, Eckert MA, Harada BT, Liu SM, Lu Z, Yu K, Tienda SM, Chryplewicz A, Zhu AC, Yang Y, Huang JT, Chen SM, Xu ZG, Leng XH, Yu XC, Cao J, Zhang Z, Liu J, Lengyel E, He C
Nature cell biology 2018 Sep;20(9):1074-1083
Nature cell biology 2018 Sep;20(9):1074-1083
A(2A) Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21.
Ruan CC, Kong LR, Chen XH, Ma Y, Pan XX, Zhang ZB, Gao PJ
Cell metabolism 2018 Sep 4;28(3):476-489.e5
Cell metabolism 2018 Sep 4;28(3):476-489.e5
Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors.
Lopez Sambrooks C, Baro M, Quijano A, Narayan A, Cui W, Greninger P, Egan R, Patel A, Benes CH, Saltzman WM, Contessa JN
Cancer research 2018 Sep 1;78(17):5094-5106
Cancer research 2018 Sep 1;78(17):5094-5106
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
Yu G, Liao J, Wu J, Ding J, Zhang L
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways.
Wang S, Wei J, Fan Y, Ding H, Tian H, Zhou X, Cheng L
Inflammation 2018 Oct;41(5):1852-1863
Inflammation 2018 Oct;41(5):1852-1863
Loss of miR-146b-3p Inhibits Perivascular Adipocyte Browning with Cold Exposure During Aging.
Pan XX, Cao JM, Cai F, Ruan CC, Wu F, Gao PJ
Cardiovascular drugs and therapy 2018 Oct;32(5):511-518
Cardiovascular drugs and therapy 2018 Oct;32(5):511-518
Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.
Xia Y, Yu B, Ma C, Tu Y, Zhai L, Yang Y, Liu D, Liu Y, Wu H, Dan H, You P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1332-1338
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1332-1338
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, Chen J, Su F, Liu Q, Song E
Cell 2018 Oct 4;175(2):442-457.e23
Cell 2018 Oct 4;175(2):442-457.e23
Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.
Rinis N, Golden JE, Marceau CD, Carette JE, Van Zandt MC, Gilmore R, Contessa JN
Cell chemical biology 2018 Oct 18;25(10):1231-1241.e4
Cell chemical biology 2018 Oct 18;25(10):1231-1241.e4
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA
The Journal of clinical investigation 2018 Oct 1;128(10):4682-4696
The Journal of clinical investigation 2018 Oct 1;128(10):4682-4696
Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning.
Mao M, Hu Y, Yang Y, Qian Y, Wei H, Fan W, Yang Y, Li X, Wang Z
Cell systems 2018 Nov 28;7(5):510-520.e4
Cell systems 2018 Nov 28;7(5):510-520.e4
Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance.
Jiang B, Lv Q, Wan W, Le L, Xu L, Hu K, Xiao P
Food & function 2018 Nov 14;9(11):5607-5620
Food & function 2018 Nov 14;9(11):5607-5620
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
Zhao N, Liang P, Zhuo X, Su C, Zong X, Guo B, Han D, Yan X, Hu S, Zhang Q, Tie X
Basic & clinical pharmacology & toxicology 2018 May;122(5):470-480
Basic & clinical pharmacology & toxicology 2018 May;122(5):470-480
PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
Papadopoulos N, Lennartsson J, Heldin CH
The Journal of cell biology 2018 May 7;217(5):1701-1717
The Journal of cell biology 2018 May 7;217(5):1701-1717
β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.
Ahmed KM, Pandita RK, Singh DK, Hunt CR, Pandita TK
Molecular and cellular biology 2018 May 1;38(9)
Molecular and cellular biology 2018 May 1;38(9)
hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1.
He X, Fan S
Oncology reports 2018 Mar;39(3):977-984
Oncology reports 2018 Mar;39(3):977-984
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.
Lan Y, Xiao X, He Z, Luo Y, Wu C, Li L, Song X
Nucleic acids research 2018 Jun 20;46(11):5809-5821
Nucleic acids research 2018 Jun 20;46(11):5809-5821
miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.
Iacona JR, Monteleone NJ, Lutz CS
Oncotarget 2018 Jun 1;9(42):26751-26769
Oncotarget 2018 Jun 1;9(42):26751-26769
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.
Hertzog J, Dias Junior AG, Rigby RE, Donald CL, Mayer A, Sezgin E, Song C, Jin B, Hublitz P, Eggeling C, Kohl A, Rehwinkel J
European journal of immunology 2018 Jul;48(7):1120-1136
European journal of immunology 2018 Jul;48(7):1120-1136
Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9.
Ci Y, Zhang Y, Liu Y, Lu S, Cao J, Li H, Zhang J, Huang Z, Zhu X, Gao J, Han M
Phytotherapy research : PTR 2018 Jul;32(7):1373-1381
Phytotherapy research : PTR 2018 Jul;32(7):1373-1381
Elevated CRB3 expression suppresses breast cancer stemness by inhibiting β-catenin signalling to restore tamoxifen sensitivity.
Li P, Feng C, Chen H, Jiang Y, Cao F, Liu J, Liu P
Journal of cellular and molecular medicine 2018 Jul;22(7):3423-3433
Journal of cellular and molecular medicine 2018 Jul;22(7):3423-3433
Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.
Smith Q, Macklin B, Chan XY, Jones H, Trempel M, Yoder MC, Gerecht S
Cell reports 2018 Jul 24;24(4):895-908.e6
Cell reports 2018 Jul 24;24(4):895-908.e6
mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways.
Yu J, Yang H, Fang B, Zhang Z, Wang Y, Dai Y
Journal of neuroscience research 2018 Jan;96(1):87-102
Journal of neuroscience research 2018 Jan;96(1):87-102
Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea.
Xiong RH, Wen SL, Wang Q, Zhou HY, Feng S
Experimental and therapeutic medicine 2018 Jan;15(1):993-998
Experimental and therapeutic medicine 2018 Jan;15(1):993-998
Tumor necrosis factor-alpha inhibits osteogenic differentiation of pre-osteoblasts by downregulation of EphB4 signaling via activated nuclear factor-kappaB signaling pathway.
Wang LM, Zhao N, Zhang J, Sun QF, Yang CZ, Yang PS
Journal of periodontal research 2018 Feb;53(1):66-72
Journal of periodontal research 2018 Feb;53(1):66-72
CD10(+)GPR77(+) Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness.
Su S, Chen J, Yao H, Liu J, Yu S, Lao L, Wang M, Luo M, Xing Y, Chen F, Huang D, Zhao J, Yang L, Liao D, Su F, Li M, Liu Q, Song E
Cell 2018 Feb 8;172(4):841-856.e16
Cell 2018 Feb 8;172(4):841-856.e16
Interleukin-6 and insulin-like growth factor-1 synergistically promote the progression of NSCLC.
Tang H, Bai Y, Pan G, Wang X, Wei Y, Yang Z, Zhao J
Autoimmunity 2018 Dec;51(8):399-407
Autoimmunity 2018 Dec;51(8):399-407
Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway.
Zhang P, Hua L, Hou H, Du X, He Z, Liu M, Hu X, Yan N
International journal of molecular medicine 2018 Dec;42(6):3344-3354
International journal of molecular medicine 2018 Dec;42(6):3344-3354
β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming.
Xie X, Jankauskas R, Mazari AMA, Drou N, Percipalle P
PLoS genetics 2018 Dec;14(12):e1007846
PLoS genetics 2018 Dec;14(12):e1007846
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
Cen B, Wei Y, Huang W, Teng M, He S, Li J, Wang W, He G, Bai X, Liu X, Yuan Y, Pan X, Ji A
Molecular therapy. Nucleic acids 2018 Dec 7;13:220-232
Molecular therapy. Nucleic acids 2018 Dec 7;13:220-232
An In Vitro Comparative Study of Multisource Derived Human Mesenchymal Stem Cells for Bone Tissue Engineering.
Zhang Y, Xing Y, Jia L, Ji Y, Zhao B, Wen Y, Xu X
Stem cells and development 2018 Dec 1;27(23):1634-1645
Stem cells and development 2018 Dec 1;27(23):1634-1645
Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats.
Liu SY, Chen L, Li XC, Hu QK, He LJ
Journal of chemical neuroanatomy 2018 Apr;89:37-42
Journal of chemical neuroanatomy 2018 Apr;89:37-42
High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer.
Chen Y, Liu J, Wang W, Xiang L, Wang J, Liu S, Zhou H, Guo Z
Oncology reports 2018 Apr;39(4):1693-1701
Oncology reports 2018 Apr;39(4):1693-1701
AmotP130 regulates Rho GTPase and decreases breast cancer cell mobility.
Chen ZL, Yang J, Shen YW, Li ST, Wang X, Lv M, Wang BY, Li P, Zhao W, Qiu RY, Liu Y, Liu PJ, Yang J
Journal of cellular and molecular medicine 2018 Apr;22(4):2390-2403
Journal of cellular and molecular medicine 2018 Apr;22(4):2390-2403
The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.
Purandare N, Somayajulu M, Hüttemann M, Grossman LI, Aras S
The Journal of biological chemistry 2018 Apr 27;293(17):6517-6529
The Journal of biological chemistry 2018 Apr 27;293(17):6517-6529
A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family.
Cui XK, Zhu KK, Zhou Z, Wan SM, Dong Y, Wang XC, Li J, Zhang J, Mu HM, Qin L, Hu YZ
International journal of ophthalmology 2017;10(5):684-690
International journal of ophthalmology 2017;10(5):684-690
Long non-coding RNA NEAT1 regulates permeability of the blood-tumor barrier via miR-181d-5p-mediated expression changes in ZO-1, occludin, and claudin-5.
Guo J, Cai H, Zheng J, Liu X, Liu Y, Ma J, Que Z, Gong W, Gao Y, Tao W, Xue Y
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2240-2254
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2240-2254
miRNA-346 promotes proliferation, migration and invasion in liver cancer.
Yu Q, Yang X, Duan W, Li C, Luo Y, Lu S
Oncology letters 2017 Sep;14(3):3255-3260
Oncology letters 2017 Sep;14(3):3255-3260
Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting.
Li Z, Yang HY, Wang Y, Zhang ML, Liu XR, Xiong Q, Zhang LN, Jin Y, Mou LS, Liu Y, Li RF, Rao Y, Dai YF
Journal of biomedical research 2017 Sep 26;31(5):445-452
Journal of biomedical research 2017 Sep 26;31(5):445-452
Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth.
Chen HY, Huang TC, Shieh TM, Wu CH, Lin LC, Hsia SM
International journal of molecular sciences 2017 Sep 21;18(10)
International journal of molecular sciences 2017 Sep 21;18(10)
Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice.
Lu T, Sun X, Li Y, Chai Q, Wang XL, Lee HC
Diabetes 2017 Oct;66(10):2681-2690
Diabetes 2017 Oct;66(10):2681-2690
p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.
Bosnakovski D, Gearhart MD, Toso EA, Recht OO, Cucak A, Jain AK, Barton MC, Kyba M
Disease models & mechanisms 2017 Oct 1;10(10):1211-1216
Disease models & mechanisms 2017 Oct 1;10(10):1211-1216
The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis.
Li H, Qiu Z, Li F, Wang C
Oncology letters 2017 Nov;14(5):5865-5870
Oncology letters 2017 Nov;14(5):5865-5870
Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.
Milewski K, Bogacińska-Karaś M, Fręśko I, Hilgier W, Jaźwiec R, Albrecht J, Zielińska M
International journal of molecular sciences 2017 Nov 2;18(11)
International journal of molecular sciences 2017 Nov 2;18(11)
Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease.
Chen R, Wang L, Liu S, Chen X, Hu Y, Liu H, Zhang H, Jiang Y, Wang Q, Ye D, Li L, Liu D, Pan X, Wei L, Li X, Zhang X
Oncotarget 2017 Nov 14;8(57):97206-97216
Oncotarget 2017 Nov 14;8(57):97206-97216
Transducin (β)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway.
Zhou Q, Wang X, Yu Z, Wu X, Chen X, Li J, Zhu Z, Liu B, Su L
Oncogene 2017 Mar 30;36(13):1873-1886
Oncogene 2017 Mar 30;36(13):1873-1886
Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation.
Li C, Zhang J, Wu H, Li L, Yang C, Song S, Peng P, Shao M, Zhang M, Zhao J, Zhao R, Wu W, Ruan Y, Wang L, Gu J
Scientific reports 2017 Mar 27;7:45275
Scientific reports 2017 Mar 27;7:45275
Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP.
Fragkouli A, Koukouraki P, Vlachos IS, Paraskevopoulou MD, Hatzigeorgiou AG, Doxakis E
Scientific reports 2017 Mar 14;7:44507
Scientific reports 2017 Mar 14;7:44507
Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.
Li C, Li L, Lin B, Fang Y, Yang H, Liu H, Xi Z
Environmental toxicology 2017 Jun;32(6):1784-1791
Environmental toxicology 2017 Jun;32(6):1784-1791
MTA1 promotes epithelial to mesenchymal transition and metastasis in non-small-cell lung cancer.
Ma K, Fan Y, Dong X, Dong D, Guo Y, Wei X, Ning J, Geng Q, Wang C, Hu Y, Li M, Niu W, Li E, Wu Y
Oncotarget 2017 Jun 13;8(24):38825-38840
Oncotarget 2017 Jun 13;8(24):38825-38840
Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.
Feng YZ, Zhang QY, Fu MT, Zhang ZF, Wei M, Zhou JY, Shi R
Oncology reports 2017 Jul;38(1):109-119
Oncology reports 2017 Jul;38(1):109-119
Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
Chen K, Liu J, Liu S, Xia M, Zhang X, Han D, Jiang Y, Wang C, Cao X
Cell 2017 Jul 27;170(3):492-506.e14
Cell 2017 Jul 27;170(3):492-506.e14
The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.
Zhao Y, Xie X, Liao W, Zhang H, Cao H, Fei R, Wang X, Wei L, Shao Q, Chen H
Oncology reports 2017 Jan;37(1):289-296
Oncology reports 2017 Jan;37(1):289-296
Correspondence: Assessment of learning, memory and attention in developmental neurotoxicology.
Sobin C
Neurotoxicology and teratology 2017 Jan-Feb;59:76-77
Neurotoxicology and teratology 2017 Jan-Feb;59:76-77
Lipid droplet biology and evolution illuminated by the characterization of a novel perilipin in teleost fish.
Granneman JG, Kimler VA, Zhang H, Ye X, Luo X, Postlethwait JH, Thummel R
eLife 2017 Feb 28;6
eLife 2017 Feb 28;6
Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway.
Chen YA, Shen YL, Hsia HY, Tiang YP, Sung TL, Chen LY
Nature structural & molecular biology 2017 Dec;24(12):1124-1131
Nature structural & molecular biology 2017 Dec;24(12):1124-1131
Bisphenol a induces autophagy and apoptosis concurrently involving the Akt/mTOR pathway in testes of pubertal SD rats.
Quan C, Wang C, Duan P, Huang W, Chen W, Tang S, Yang K
Environmental toxicology 2017 Aug;32(8):1977-1989
Environmental toxicology 2017 Aug;32(8):1977-1989
N-acetylcysteine ameliorates repetitive/stereotypic behavior due to its antioxidant properties without activation of the canonical Wnt pathway in a valproic acid-induced rat model of autism.
Zhang Y, Cui W, Zhai Q, Zhang T, Wen X
Molecular medicine reports 2017 Aug;16(2):2233-2240
Molecular medicine reports 2017 Aug;16(2):2233-2240
Blocking the recruitment of naive CD4(+) T cells reverses immunosuppression in breast cancer.
Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wu W, Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD, Lieberman J, Liu Q, Song E
Cell research 2017 Apr;27(4):461-482
Cell research 2017 Apr;27(4):461-482
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
Shah SZA, Zhao D, Taglialatela G, Khan SH, Hussain T, Dong H, Lai M, Zhou X, Yang L
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):463-483
CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin.
Li P, Wang Y, Mao X, Jiang Y, Liu J, Li J, Wang J, Wang R, She J, Zhang J, Yang J, Liu Y, Liu P
Oncogenesis 2017 Apr 24;6(4):e322
Oncogenesis 2017 Apr 24;6(4):e322
Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.
Gan Z, Han K, Lin S, Hu H, Shen Z, Min D
Biological research 2017 Apr 12;50(1):15
Biological research 2017 Apr 12;50(1):15
Electroacupuncture Promotes Remyelination after Cuprizone Treatment by Enhancing Myelin Debris Clearance.
Zhu K, Sun J, Kang Z, Zou Z, Wu G, Wang J
Frontiers in neuroscience 2016;10:613
Frontiers in neuroscience 2016;10:613
Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice.
Wu CH, Chen HY, Wang CW, Shieh TM, Huang TC, Lin LC, Wang KL, Hsia SM
Oncotarget 2016 Nov 8;7(45):73432-73447
Oncotarget 2016 Nov 8;7(45):73432-73447
Keap1 hypomorphism protects against ischemic and obstructive kidney disease.
Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y
Scientific reports 2016 Nov 2;6:36185
Scientific reports 2016 Nov 2;6:36185
Eupolyphaga sinensis Walker Ethanol Extract Suppresses Cell Growth and Invasion in Human Breast Cancer Cells.
Zhan Y, Zhang H, Liu R, Wang W, Qi J, Zhang Y
Integrative cancer therapies 2016 Mar;15(1):102-12
Integrative cancer therapies 2016 Mar;15(1):102-12
Recombinant adeno-associated virus-delivered anginex inhibits angiogenesis and growth of HUVECs by regulating the Akt, JNK and NF-κB signaling pathways.
Ma K, Wang C, Geng Q, Fan Y, Ning J, Yang H, Dong X, Dong D, Guo Y, Wei X, Li E, Wu Y
Oncology reports 2016 Jun;35(6):3505-13
Oncology reports 2016 Jun;35(6):3505-13
System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Western blot analysis of GAPDH in various tissues and cell lines using Proteintech antibody HRP-60004 at a dilution of 1:10000.
- Sample type
- tissue
