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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [610]
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- Product number
- HRP-60004 - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#HRP-60004, RRID:AB_2737588
- Product name
- GAPDH antibody
- Antibody type
- Monoclonal
- Description
- GAPDH antibody (Cat. #HRP-60004) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat, zebrafish, plant and has been validated for the following applications: WB.
- Reactivity
- Human, Mouse, Rat, Zebrafish
- Host
- Mouse
- Conjugate
- Horseradish Peroxidase
- Isotype
- IgG
- Antibody clone number
- 1E6D9
- Vial size
- 100ul
Submitted references The FTO Mediated N6-Methyladenosine Modification of DDIT4 Regulation with Tumorigenesis and Metastasis in Prostate Cancer.
Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells.
FLNB overexpression promotes tumor progression and associates with immune suppression, evasion and stemness in pancreatic cancer.
Unveiling a new strategy for PDIA1 inhibition: Integration of activity-based probes profiling and targeted degradation.
Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
Edaravone Maintains AQP4 Polarity Via OS/MMP9/β-DG Pathway in an Experimental Intracerebral Hemorrhage Mouse Model.
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
LINC01572 promotes triple-negative breast cancer progression through EIF4A3-mediated β-catenin mRNA nuclear exportation.
Inhibition of influenza A virus and SARS-CoV-2 infection or co-infection by griffithsin and griffithsin-based bivalent entry inhibitor.
A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K/AKT/mTOR signaling pathway.
Podocyte-Specific Deletion of MCP-1 Fails to Protect against Angiotensin II- or Adriamycin-Induced Glomerular Disease.
Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation.
Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1.
Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel Disease.
In-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level.
Effects of chronic Cr and Ni co-exposure on liver inflammation and autophagy in mice by regulating the TLR4/mTOR pathway.
Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury.
Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity.
CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.
Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids.
Mitotic Spindle Positioning (MISP) Facilitates Colorectal Cancer Progression by Forming a Complex with Opa Interacting Protein 5 (OIP5) and Activating the JAK2-STAT3 Signaling Pathway.
Novel Diagnostic Biomarker BST2 Identified by Integrated Transcriptomics Promotes the Development of Endometriosis via the TNF-α/NF-κB Signaling Pathway.
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Large-scale RNA-seq mining reveals ciclopirox triggers TDP-43 cryptic exons.
Roseburia intestinalis sensitizes colorectal cancer to radiotherapy through the butyrate/OR51E1/RALB axis.
Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA.
Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer.
Idebenone ameliorates statin-induced myotoxicity in atherosclerotic ApoE-/- mice by reducing oxidative stress and improving mitochondrial function.
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.
Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periosti.
Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury.
Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides.
CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair.
IL-1β-Stimulated Bone Mesenchymal Stem Cell-Derived Exosomes Mitigate Sepsis through Modulation of HMGB1/AKT Pathway and M2 Macrophage Polarization.
Rapid and comprehensive metabolites identification of 5-demethylnobiletin in rats using UPLC/Triple-TOF-MS/MS based on multiple mass defect filter and their neuroprotection against ferroptosis.
KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.
Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility†.
Adventitial delivery of miR-145 to treat intimal hyperplasia post vascular injuries through injectable and in-situ self-assembling peptide hydrogels.
Ceramide enhanced the hepatic glucagon response through regulation of CREB activity.
Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice.
UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.
Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape.
Bleomycin reduces Vairimorpha (Nosema) ceranae infection in honey bees with some evident host toxicity.
IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1.
Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells.
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib.
The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway.
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling.
Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis.
Characterization of immunogenic cell death regulators predicts survival and immunotherapy response in lung adenocarcinoma.
Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy.
Macrocarpal B blocks the binding between the phospholipase A2 receptor and its antibodies.
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.
M2 macrophage-derived exosomes carry miR-142-3p to restore the differentiation balance of irradiated BMMSCs by targeting TGF-β1.
Coptisine inhibits neointimal hyperplasia through attenuating Pak1/Pak2 signaling in vascular smooth muscle cells without retardation of re-endothelialization.
Age-Related Gut Microbiota Transplantation Disrupts Myocardial Energy Homeostasis and Induces Oxidative Damage.
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
Schisandrin A alleviates renal fibrosis by inhibiting PKCβ and oxidative stress.
Co-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis.
PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis.
Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets.
Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation.
GDF9(His209GlnfsTer6/S428T) and GDF9(Q321X/S428T) bi-allelic variants caused female subfertility with defective follicle enlargement.
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.
The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression.
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease.
Ferrostatin-1 mitigates ionizing radiation-induced intestinal injuries by inhibiting apoptosis and ferroptosis: an in vitro and in vivo study.
Electric field promotes dermal fibroblast transdifferentiation through activation of RhoA/ROCK1 pathway.
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer.
Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis.
Electroacupuncture alleviated depression-like behaviors in ventromedial prefrontal cortex of chronic unpredictable mild stress-induced rats: Increasing synaptic transmission and phosphorylating dopamine transporter.
Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ.
hESC-Derived Epicardial Cells Promote Repair of Infarcted Hearts in Mouse and Swine.
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss.
Identification of VPS34-PI(3)P-FEN1-mediated DNA repair pathway as a potential drug target to overcome chemoresistance.
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis.
A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease.
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.
Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism.
Evaluation of the radiosensitizing effect of MEK inhibitor KZ-001 on non-small cell lung cancer cells in vitro.
Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction proteins and the TRPA1 modulation.
Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.
Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response.
Chimpanzee adenovirus-mediated multiple gene therapy for age-related macular degeneration.
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein.
Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups.
Lycorine promotes IDH1 acetylation to induce mitochondrial dynamics imbalance in colorectal cancer cells.
An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity.
Assigning functionality to cysteines by base editing of cancer dependency genes.
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer.
Towards modular engineering of cell signalling: Topographically-textured microparticles induce osteogenesis via activation of canonical hedgehog signalling.
Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8(+) T cells.
Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti-Tumor Immunity.
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase.
ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria.
Compound 5 alleviated acute kidney injury without affecting the antitumor effect after cisplatin treatment.
KZ02 enhances the radiosensitivity of BRAF-mutated CRC in vitro and in vivo.
Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells.
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Melatonin ameliorates histone modification disorders in mammalian aged oocytes by neutralizing the alkylation of HDAC1.
Gigaxonin is required for intermediate filament transport.
An A-kinase anchoring protein (ACBD3) coordinates traffic-induced PKA activation at the Golgi.
Microglial P2Y12 Signaling Contributes to Cisplatin-induced Pain Hypersensitivity via IL-18-mediated Central Sensitization in the Spinal Cord.
Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders.
Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice.
Deletion of Arrb2 Down-regulates Autophagy in the Mouse Hippocampus via Akt-mTOR Pathway Activation.
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Bmi-1 Overexpression Improves Sarcopenia Induced by 1,25(OH)(2) D(3) Deficiency and Downregulates GATA4-Dependent Rela Transcription.
Inherent Capability of Self-Assembling Nanostructures in Specific Proteasome Activation for Cancer Cell Pyroptosis.
Human MD2 deficiency-an inborn error of immunity with pleiotropic features.
Identification of novel NFKB1 and ICOS frameshift variants in patients with CVID.
Effect of dermatopontin on osteogenic differentiation of periodontal ligament stem cells.
NUSAP1 Binds ILF2 to Modulate R-Loop Accumulation and DNA Damage in Prostate Cancer.
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
The Regulation of ZIP8 by Dietary Manganese in Mice.
The Effect of Cholesterol Efflux on Endothelial Dysfunction Caused by Oxidative Stress.
CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasis.
The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma.
CD8+ T cell-Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance.
TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate.
Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinoma.
"Untargeting" autoantibodies using genome editing, a proof-of-concept study.
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.
HSPA5, as a ferroptosis regulator, may serve as a potential therapeutic for head and neck squamous cell carcinoma.
Sunitinib attenuates reactive MDSCs enhancing anti-tumor immunity in HNSCC.
Differential intracellular trafficking of extracellular vesicles in microglia and astrocytes.
Chemotherapeutic drugs-induced pyroptosis mediated by gasdermin E promotes the progression and chemoresistance of pancreatic cancer.
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice.
Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.
An In Vivo CRISPR Screen Identifies That SNRPC Promotes Triple-Negative Breast Cancer Progression.
Role of ADAM33 short isoform as a tumor suppressor in the pathogenesis of thyroid cancer via oncogenic function disruption of full-length ADAM33.
PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla.
PDZD8-mediated endoplasmic reticulum-mitochondria associations regulate sympathetic drive and blood pressure through the intervention of neuronal mitochondrial homeostasis in stress-induced hypertension.
Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.
Hierarchically Injectable Hydrogel Sequentially Delivers AntagomiR-467a-3p-Loaded and AntagomiR-874-5p-Loaded Satellite-Cell-Targeting Bioengineered Extracellular Vesicles Attenuating Sarcopenia.
Conoidin A, a Covalent Inhibitor of Peroxiredoxin 2, Reduces Growth of Glioblastoma Cells by Triggering ROS Production.
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles.
Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model.
Hepatic DKK1-driven steatosis is CD36 dependent.
p53 downregulates PD-L1 expression via miR-34a to inhibit the growth of triple-negative breast cancer cells: a potential clinical immunotherapeutic target.
De Novo Somatic Mosaicism of CYBB Caused by Intronic LINE-1 Element Insertion Resulting in Chronic Granulomatous Disease.
CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype.
The novel sustained 3-hydroxybutyrate donor poly-D-3-hydroxybutyric acid prevents inflammatory bowel disease through upregulation of regulatory T-cells.
IKKα aggravates renal fibrogenesis by positively regulating the Wnt/β-catenin pathway.
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability.
Lactate metabolism is essential in early-onset mitochondrial myopathy.
PCIF1-mediated deposition of 5'-cap N(6),2'-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection.
Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis.
Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.
Polycationic PAMAM ameliorates obesity-associated chronic inflammation and focal adiposity.
miRNA‑92a inhibits vascular smooth muscle cell phenotypic modulation and may help prevent in‑stent restenosis.
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening.
Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.
Genetic background strongly influences the transition to chronic kidney disease of adriamycin nephropathy in mice.
PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis.
BRPF1 bridges H3K4me3 and H3K23ac in human embryonic stem cells and is essential to pluripotency.
Effect of Zbed6 Single-Allele Knockout on the Growth and Development of Skeletal Muscle in Mice.
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Mitotic spindle positioning protein (MISP) deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis in mice.
The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice.
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production.
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
A novel homozygous Y140X mutation of ISG15 causes diverse type I interferonopathies in sibling patients with cutaneous lesions or recurrent parenchymal pneumonia.
METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis.
Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
GmPLP1 negatively regulates soybean resistance to high light stress by modulating photosynthetic capacity and reactive oxygen species accumulation in a blue light-dependent manner.
The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation.
BPTF Drives Gastric Cancer Resistance to EGFR Inhibitor by Epigenetically Regulating the C-MYC/PLCG1/Perk Axis.
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
CREB1 Facilitates GABAergic Neural Differentiation of Human Mesenchymal Stem Cells through BRN2 for Pain Alleviation and Locomotion Recovery after Spinal Cord Injury.
Choroid plexus mast cells drive tumor-associated hydrocephalus.
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease.
Single amino acid-based PROTACs trigger degradation of the oncogenic kinase BCR-ABL in chronic myeloid leukemia (CML).
Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin.
Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy.
Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition.
OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer.
Haspin balances the ratio of asymmetric cell division through Wnt5a and regulates cell fate decisions in mouse embryonic stem cells.
XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to -4) Using a Newly Developed DENV-3 Infectious Clone and Replicon.
Expression and function of patatin-like phospholipase domain-containing 2 in cleft palate induced by retinoic acid.
A neuron-specific Isca1 knockout rat developments multiple mitochondrial dysfunction syndromes.
Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer.
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
Conserved NIMA kinases regulate multiple steps of endocytic trafficking.
NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).
KDEL Receptor Trafficking to the Plasma Membrane Is Regulated by ACBD3 and Rab4A-GTP.
Gomisin D alleviates liver fibrosis through targeting PDGFRβ in hepatic stellate cells.
A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns.
FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.
A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model.
Syndecan-1 as an immunogene in Triple-negative breast cancer: regulation tumor-infiltrating lymphocyte in the tumor microenviroment and EMT by TGFb1/Smad pathway.
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer.
Artemin Promotes the Migration and Invasion of Cervical Cancer Cells through AKT/mTORC1 Signaling.
Elevated FOXA1 Expression Indicates Poor Prognosis in Liver Cancer due to Its Effects on Cell Proliferation and Metastasis.
Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.
Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.
Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis.
Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1.
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy.
Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis.
A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C.
Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.
Ruxolitinib attenuates secondary injury after traumatic spinal cord injury.
MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer.
Pangenomic analysis of Chinese gastric cancer.
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.
E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma.
Suppression of macrophage-mediated xenogeneic rejection by the ectopic expression of human CD177.
A non-metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11-mediated CD133 stability.
Autoregulation of H(+)/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.
Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.
Identification of SLC3A2 as a Potential Therapeutic Target of Osteoarthritis Involved in Ferroptosis by Integrating Bioinformatics, Clinical Factors and Experiments.
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome.
Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice.
Excessive activation of HOXB13/PIMREG axis promotes hepatocellular carcinoma progression and drug resistance.
Coronin2A links actin-based endosomal processes to the EHD1 fission machinery.
Genetic and Functional Identifying of Novel STAT1 Loss-of-Function Mutations in Patients with Diverse Clinical Phenotypes.
Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability.
Tp47 promoted the phagocytosis of HMC3 cells though autophagy induced by endoplamic reticlum stress.
Combined Therapy of Low-Dose Angiotensin Receptor-Neprilysin Inhibitor and Sodium-Glucose Cotransporter-2 Inhibitor Prevents Doxorubicin-Induced Cardiac Dysfunction in Rodent Model with Minimal Adverse Effects.
Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors.
Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer.
Deficiency of CD93 exacerbates inflammation-induced activation and migration of BV2 microglia by regulating the TAK1/NF-κB pathway.
CD16(+) fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition.
Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo.
Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
Defining the Skeletal Myogenic Lineage in Human Pluripotent Stem Cell-Derived Teratomas.
Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins.
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.
Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice.
Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.
The retromer complex regulates C. elegans development and mammalian ciliogenesis.
Direct targeting of amplified gene loci for proapoptotic anticancer therapy.
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.
Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.
Sexual dimorphic impacts of systemic vincristine on lower urinary tract function.
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Up-regulation of miR-335 and miR-674-3p in the rostral ventrolateral medulla contributes to stress-induced hypertension.
Pervasive translation of circular RNAs driven by short IRES-like elements.
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.
The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice.
MEK1/2 inhibitors induce class I alcohol dehydrogenase (ADH1) expression by regulating farnesoid X receptor in hepatic cell lines and C57BL/6J mouse.
Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis.
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice.
Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.
Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.
C-type lectin domain-containing protein CLEC3A regulates proliferation, regeneration and maintenance of nucleus pulposus cells.
FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.
DSCAM-AS1 Long Non-Coding RNA Exerts Oncogenic Functions in Endometrial Adenocarcinoma via Activation of a Tumor-Promoting Transcriptome Profile.
UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity via modulating unfolded protein response.
PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1.
CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway.
Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
LRRK2 is required for CD38-mediated NAADP-Ca(2+) signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma.
Proteomic analysis of opossum Monodelphis domestica spinal cord reveals the changes of proteins related to neurodegenerative diseases during developmental period when neuroregeneration stops being possible.
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.
Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80.
The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.
Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability.
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification.
Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition.
Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice.
Effects of the Water Extract of Fermented Rice Bran on Liver Damage and Intestinal Injury in Aged Rats with High-Fat Diet Feeding.
The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2.
Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.
Hypoxic preconditioning promotes galvanotaxis of human dermal microvascular endothelial cells through NF-κB pathway.
Single-cell transcriptional profiling reveals heterogeneity and developmental trajectories of Ewing sarcoma.
Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR.
VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.
Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.
Genome-Wide Analysis of Circular RNAs Reveals circCHRNG Regulates Sheep Myoblast Proliferation via miR-133/SRF and MEF2A Axis.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Resveratrol activates the SIRT1/PGC-1 pathway in mice to improve synaptic-related cognitive impairment after TBI.
The DEAD-box helicase DDX3x ameliorates non-alcoholic fatty liver disease via mTORC1 signalling pathway.
Spirulina phycocyanin extract and its active components suppress epithelial-mesenchymal transition process in endometrial cancer via targeting TGF-beta1/SMAD4 signaling pathway.
Rational Design and Optimization of m(6)A-RNA Demethylase FTO Inhibitors as Anticancer Agents.
Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.
Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity.
AKT serine/threonine kinase 2-mediated phosphorylation of fascin threonine 403 regulates esophageal cancer progression.
A functional PVA aerogel-based membrane obtaining sutureability through modified electrospinning technology and achieving promising anti-adhesion effect after cardiac surgery.
Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma.
The Role of ATF3 in Neuronal Differentiation and Development of Neuronal Networks in Opossum Postnatal Cortical Cultures.
Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via TRIM21, leading to cell death and defective myogenesis.
Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
Characteristics of the Gut Microbiome and IL-13/TGF-β1 Mediated Fibrosis in Post-Kasai Cholangitis of Biliary Atresia.
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes.
Development and Validation of a Ferroptosis-Related Gene Signature for Overall Survival Prediction in Lung Adenocarcinoma.
WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells.
Samm50 Promotes Hypertrophy by Regulating Pink1-Dependent Mitophagy Signaling in Neonatal Cardiomyocytes.
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules.
Indoleamine-2,3-Dioxygenase Activates Wnt/β-Catenin Inducing Kidney Fibrosis after Acute Kidney Injury.
JNK Signaling Pathway Mediates Fluoride-Induced Upregulation of CK1α during Enamel Formation.
Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway.
miR-708 Negatively Regulates TNFα/IL-1β Signaling by Suppressing NF-κB and Arachidonic Acid Pathways.
Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells.
Valproic Acid Induces Autism-Like Synaptic and Behavioral Deficits by Disrupting Histone Acetylation of Prefrontal Cortex ALDH1A1 in Rats.
Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release.
Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease.
Bifidobacterium infantis Maintains Genome Stability in Ulcerative Colitis via Regulating Anaphase-Promoting Complex Subunit 7.
TAZ maintains telomere length in TNBC cells by mediating Rad51C expression.
PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
Discovery of Potent Antiallergic Agents Based on an o-Aminopyridinyl Alkynyl Scaffold.
HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1.
A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
IKKε knockout alleviates angiotensin II-induced apoptosis and excessive autophagy in vascular smooth muscle cells by regulating the ERK1/2 pathway.
Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets.
Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.
Disrupting RhoA activity by blocking Arhgef3 expression mitigates microglia-induced neuroinflammation post spinal cord contusion.
Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss.
Effect of Metformin and Simvastatin in Inhibiting Proadipogenic Transcription Factors.
Effects of aging on the histology and biochemistry of rat tendon healing.
11βHSD2 Efficacy in Preventing Transcriptional Activation of the Mineralocorticoid Receptor by Corticosterone.
HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production.
Fzd7/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer.
Silencing TAK1 reduces MAPKs-MMP2/9 expression to reduce inflammation-driven neurohistological disruption post spinal cord injury.
Highly Conserved C-Terminal Region of Indian Hedgehog N-Fragment Contributes to Its Auto-Processing and Multimer Formation.
Analyses of key mRNAs and lncRNAs for different osteo-differentiation potentials of periodontal ligament stem cell and gingival mesenchymal stem cell.
EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function.
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.
Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation.
Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis.
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Mitochondrial activity regulates the differentiation of skin-derived mesenchymal stem cells into brown adipocytes to contribute to hypertension.
Development and Validation of High-Content Analysis for Screening HDAC6-Selective Inhibitors.
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.
A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer.
An Ultra-Stable, Oxygen-Supply Nanoprobe Emitting in Near-Infrared-II Window to Guide and Enhance Radiotherapy by Promoting Anti-Tumor Immunity.
WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression.
Downregulation of Prolactin-Induced Protein Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells.
A single amino acid substitution in PRKDC is a determinant of sensitivity to Adriamycin-induced renal injury in mouse.
Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure.
Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.
DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells.
The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer.
Perturbation of astroglial Slc38 glutamine transporters by NH(4)(+) contributes to neurophysiologic manifestations in acute liver failure.
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.
Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways.
Rice Husk Silica Liquid Protects Pancreatic β Cells from Streptozotocin-Induced Oxidative Damage.
Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE).
Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human.
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.
Citrate regulates extracellular matrix mineralization during osteoblast differentiation in vitro.
Defining the protein and lipid constituents of tubular recycling endosomes.
GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
Lipolytic gene DAGLA is targeted by miR-223 in chicken hepatocytes.
Maternal vitamin A deficiency impairs cholinergic and nitrergic neurons, leading to gastrointestinal dysfunction in rat offspring via RARβ.
Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model.
Pyrvinium pamoate inhibits cell proliferation through ROS-mediated AKT-dependent signaling pathway in colorectal cancer.
Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.
Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors.
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Halofuginone triggers a transcriptional program centered on ribosome biogenesis and function in honey bees.
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.
TTP protects against acute liver failure by regulating CCL2 and CCL5 through m6A RNA methylation.
Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells.
Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.
Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma.
2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.
HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity.
The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer.
Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors.
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer.
The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma.
miR-3 Encoded by Hepatitis B Virus Downregulates PTEN Protein Expression and Promotes Cell Proliferation.
Electric field down-regulates CD9 to promote keratinocytes migration through AMPK pathway.
LRG1 promotes corneal angiogenesis and lymphangiogenesis in a corneal alkali burn mouse model.
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.
Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model.
Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis.
Total Glycosides of Cistanche deserticola Promote Neurological Function Recovery by Inducing Neurovascular Regeneration via Nrf-2/Keap-1 Pathway in MCAO/R Rats.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/β-Catenin Signaling Pathway.
Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria.
Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy via Suppression of Atrogin-1.
FAM122A Inhibits Erythroid Differentiation through GATA1.
Non-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1.
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
High salt diet may promote progression of breast tumor through eliciting immune response.
Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.
Physiology and Morphological Correlates of Excitatory Transmission are Preserved in Glutamine Transporter SN1-Depleted Mouse Frontal Cortex.
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.
Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy.
Endoplasmic Reticulum Stress Affects Cholesterol Homeostasis by Inhibiting LXRα Expression in Hepatocytes and Macrophages.
The beneficial effect of oyster peptides and oyster powder on cyclophosphamide-induced reproductive impairment in male rats: A comparative study.
Suppressor of Ty 16 promotes lung cancer malignancy and is negatively regulated by miR-1227-5p.
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
Magnesium Calcium Phosphate Cement Incorporating Citrate for Vascularized Bone Regeneration.
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer.
Knockout of mouse receptor accessory protein 6 leads to sperm function and morphology defects†.
Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA.
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.
Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles.
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage.
HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism.
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.
Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade.
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway.
HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV.
Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer.
Calcium Channel α2δ1 Subunit Mediates Secondary Orofacial Hyperalgesia Through PKC-TRPA1/Gap Junction Signaling.
Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.
Glibenclamide ameliorates transplant-induced arteriosclerosis and inhibits macrophage migration and MCP-1 expression.
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.
Adenosine A(2A) receptor activation prevents DOCA-salt induced hypertensive cardiac remodeling via iBAT.
Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway.
Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes.
Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.
Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation.
Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell carcinoma metastasis by regulating Snail.
PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.
miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells.
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.
Protocol for Site-Specific Photo-Crosslinking Proteomics to Identify Protein-Protein Interactions in Mammalian Cells.
PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment.
Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
TNF‑α treatment increases DKK1 protein levels in primary osteoblasts via upregulation of DKK1 mRNA levels and downregulation of miR‑335‑5p.
Downregulation of GPR183 on infection restricts the early infection and intracellular replication of mycobacterium tuberculosis in macrophage.
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Hydroxysafflor yellow A induces autophagy in human liver cancer cells by regulating Beclin 1 and ERK expression.
STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease.
Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer.
EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation.
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
Intravaginal Administration of Human Type III Collagen-Derived Biomaterial with High Cell-Adhesion Activity to Treat Vaginal Atrophy in Rats.
Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel.
X-linked inhibitor of apoptosis protein accelerates migration by inducing epithelial-mesenchymal transition through TGF-β signaling pathway in esophageal cancer cells.
Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development.
Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL.
SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes.
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.
Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.
CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17.
Long Noncoding RNA GAS5 Acts As A Tumor Suppressor In Laryngeal Squamous Cell Carcinoma Via miR-21.
Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis.
Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion.
A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.
Nicotinic acetylcholine receptor subunit expression in the gastrocnemius and in the orbicularis oris before and after facial nerve injury in rats.
Different signalling in infarcted and non-infarcted areas of rat failing hearts: A role of necroptosis and inflammation.
Potential roles of lncRNA-Cox2 and EGR1 in regulating epidural fibrosis following laminectomy.
Regulation of the Metal Transporters ZIP14 and ZnT10 by Manganese Intake in Mice.
miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.
Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress.
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
Increased miRNA-518b inhibits trophoblast migration and angiogenesis by targeting EGR1 in early embryonic arrest†.
Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer.
Analyses of epithelial Na(+) channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating.
Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
The mTOR-RUNX1 pathway regulates DC-SIGN expression in renal tubular epithelial cells.
Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane.
The role of ZBTB38 in promoting migration and invasive growth of bladder cancer cells.
Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration.
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.
Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop.
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
Programmable RNA-Guided RNA Effector Proteins Built from Human Parts.
Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
Thermoregulation via Temperature-Dependent PGD(2) Production in Mouse Preoptic Area.
MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.
Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism.
Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes.
Spinal Serotonin 1A Receptor Contributes to the Analgesia of Acupoint Catgut Embedding by Inhibiting Phosphorylation of the N-Methyl-d-Aspartate Receptor GluN1 Subunit in Complete Freund's Adjuvant-Induced Inflammatory Pain in Rats.
Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition.
PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.
Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway.
Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells.
Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs.
MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.
Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells.
Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.
Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.
Rutin promotes the formation and osteogenic differentiation of human periodontal ligament stem cell sheets in vitro.
A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability.
Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery.
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription.
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.
Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA) Requires Death Receptor Fas, in Addition to LFA-1, To Trigger Cell Death in T Lymphocytes.
Palmitoylation is required for TNF-R1 signaling.
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Mutations in topoisomerase IIβ result in a B cell immunodeficiency.
CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.
BP‑1‑102 exerts an antitumor effect on the AGS human gastric cancer cell line through modulating the STAT3 and MAPK signaling pathways.
Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production.
miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
FEZF1 is an Independent Predictive Factor for Recurrence and Promotes Cell Proliferation and Migration in Cervical Cancer.
Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer.
Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.
Decrease of Perivascular Adipose Tissue Browning Is Associated With Vascular Dysfunction in Spontaneous Hypertensive Rats During Aging.
Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A.
The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer.
m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
A(2A) Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21.
Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors.
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways.
Loss of miR-146b-3p Inhibits Perivascular Adipocyte Browning with Cold Exposure During Aging.
Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning.
Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance.
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.
hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1.
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.
miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.
Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9.
Elevated CRB3 expression suppresses breast cancer stemness by inhibiting β-catenin signalling to restore tamoxifen sensitivity.
Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.
mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways.
Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea.
Tumor necrosis factor-alpha inhibits osteogenic differentiation of pre-osteoblasts by downregulation of EphB4 signaling via activated nuclear factor-kappaB signaling pathway.
CD10(+)GPR77(+) Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness.
Interleukin-6 and insulin-like growth factor-1 synergistically promote the progression of NSCLC.
Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway.
β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming.
An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.
An In Vitro Comparative Study of Multisource Derived Human Mesenchymal Stem Cells for Bone Tissue Engineering.
Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats.
High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer.
AmotP130 regulates Rho GTPase and decreases breast cancer cell mobility.
The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.
A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family.
Long non-coding RNA NEAT1 regulates permeability of the blood-tumor barrier via miR-181d-5p-mediated expression changes in ZO-1, occludin, and claudin-5.
miRNA-346 promotes proliferation, migration and invasion in liver cancer.
Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting.
Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth.
Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice.
p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.
The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis.
Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.
Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation.
Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP.
Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.
MTA1 promotes epithelial to mesenchymal transition and metastasis in non-small-cell lung cancer.
Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.
Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.
Correspondence: Assessment of learning, memory and attention in developmental neurotoxicology.
Lipid droplet biology and evolution illuminated by the characterization of a novel perilipin in teleost fish.
Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway.
N-acetylcysteine ameliorates repetitive/stereotypic behavior due to its antioxidant properties without activation of the canonical Wnt pathway in a valproic acid-induced rat model of autism.
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.
CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin.
Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.
Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice.
Eupolyphaga sinensis Walker Ethanol Extract Suppresses Cell Growth and Invasion in Human Breast Cancer Cells.
System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.
c-Myc plays a key role in TADs-induced apoptosis and cell cycle arrest in human hepatocellular carcinoma cells.
Pigment Epithelium-Derived Factor Induces Endothelial Barrier Dysfunction via p38/MAPK Phosphorylation.
miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.
Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma.
Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.
Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma.
Elabela-apelin receptor signaling pathway is functional in mammalian systems.
Momordica cochinchinensis seed extracts suppress migration and invasion of human breast cancer ZR-75-30 cells via down-regulating MMP-2 and MMP-9.
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.
Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.
Zhao Y, Hu X, Yu H, Sun H, Zhang L, Shao C
Research (Washington, D.C.) 2024;7:0313
Research (Washington, D.C.) 2024;7:0313
Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells.
Zi G, Chen J, Peng Y, Wang Y, Peng B
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2024;41(1):2325489
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2024;41(1):2325489
FLNB overexpression promotes tumor progression and associates with immune suppression, evasion and stemness in pancreatic cancer.
Fan G, Yan Q, Chen Y, Han M, Wu Z, Ruan S, Zhuang H, Gou Q, Hou B
American journal of cancer research 2024;14(2):709-726
American journal of cancer research 2024;14(2):709-726
Unveiling a new strategy for PDIA1 inhibition: Integration of activity-based probes profiling and targeted degradation.
Zhang B, Hong D, Qian H, Ma K, Zhu L, Jiang L, Ge J
Bioorganic chemistry 2024 Sep;150:107585
Bioorganic chemistry 2024 Sep;150:107585
Lipid-siRNA conjugate accesses perivascular transport and achieves durable knockdown throughout the central nervous system.
Sorets AG, Schwensen KR, Francini N, Kjar A, Abdulrahman AM, Shostak A, Katdare KA, Schoch KM, Cowell RP, Park JC, Ligocki AP, Ford WT, Ventura-Antunes L, Hoogenboezem EN, Prusky A, Castleberry M, Michell DL, Miller TM, Vickers KC, Schrag MS, Duvall CL, Lippmann ES
bioRxiv : the preprint server for biology 2024 Sep 7;
bioRxiv : the preprint server for biology 2024 Sep 7;
Edaravone Maintains AQP4 Polarity Via OS/MMP9/β-DG Pathway in an Experimental Intracerebral Hemorrhage Mouse Model.
Wang Z, Li Y, Wang Z, Liao Y, Ye Q, Tang S, Wei T, Xiao P, Huang J, Lu W
Molecular neurobiology 2024 Oct;61(10):7639-7658
Molecular neurobiology 2024 Oct;61(10):7639-7658
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Yan P, Yang K, Xu M, Zhu M, Duan Y, Li W, Liu L, Liang C, Li Z, Pan X, Wang L, Yu G
Journal of molecular cell biology 2024 Oct 21;16(5)
Journal of molecular cell biology 2024 Oct 21;16(5)
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
Liu J, Gao L, Zhou N, Jiang Z, Che S, Deng Y, Zang N, Ren L, Xie X, Xie J, Liu E
Virology 2024 May;593:110018
Virology 2024 May;593:110018
LINC01572 promotes triple-negative breast cancer progression through EIF4A3-mediated β-catenin mRNA nuclear exportation.
Zheng B, Zhou B, Ye D, Wang Y, Zheng W, Wang X, Liu D, Qian F, Zhou X, Yan T, Li Y, Fang L
Environmental toxicology 2024 May;39(5):3026-3039
Environmental toxicology 2024 May;39(5):3026-3039
Inhibition of influenza A virus and SARS-CoV-2 infection or co-infection by griffithsin and griffithsin-based bivalent entry inhibitor.
Cao N, Cai Y, Huang X, Jiang H, Huang Z, Xing L, Lu L, Jiang S, Xu W
mBio 2024 May 8;15(5):e0074124
mBio 2024 May 8;15(5):e0074124
A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K/AKT/mTOR signaling pathway.
Fu J, Liang P, Zheng Y, Xu C, Xiong F, Yang F
Gene 2024 May 30;909:148312
Gene 2024 May 30;909:148312
Podocyte-Specific Deletion of MCP-1 Fails to Protect against Angiotensin II- or Adriamycin-Induced Glomerular Disease.
Bondi CD, Hartman HL, Rush BM, Tan RJ
International journal of molecular sciences 2024 May 3;25(9)
International journal of molecular sciences 2024 May 3;25(9)
Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation.
Wang S, Li W, Wang L, Tiwari SK, Bray W, Wu L, Li N, Hui H, Clark AE, Zhang Q, Zhang L, Carlin AF, Rana TM
bioRxiv : the preprint server for biology 2024 May 3;
bioRxiv : the preprint server for biology 2024 May 3;
Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1.
Zhou X, Zhang K, Wang C, Teng Y, Yu P, Cai W, Gao W, Li M, Ding Y, Sun P, Chen F, Wang Y, Ma J, Maeshige N, Ma X, Li Q, Liang X, Zhang Y, Su D
Cancer letters 2024 May 28;590:216868
Cancer letters 2024 May 28;590:216868
Readily Available Oral Prebiotic Protein Reactive Oxygen Species Nanoscavengers for Synergistic Therapy of Inflammation and Fibrosis in Inflammatory Bowel Disease.
Yu Y, Yang D, Lin B, Zhu L, Li C, Li X
ACS nano 2024 May 28;18(21):13583-13598
ACS nano 2024 May 28;18(21):13583-13598
In-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level.
Qin S, Zhang Y, Shi M, Miao D, Lu J, Wen L, Bai Y
Nature communications 2024 May 23;15(1):4387
Nature communications 2024 May 23;15(1):4387
Effects of chronic Cr and Ni co-exposure on liver inflammation and autophagy in mice by regulating the TLR4/mTOR pathway.
Cao X, Zheng S, Zeng Y, Shi Y, Du J, Huang C, Shen Y, Liu P, Guo X, Gao X
The Science of the total environment 2024 May 20;926:171921
The Science of the total environment 2024 May 20;926:171921
Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury.
Qian Z, Li R, Zhao T, Xie K, Li P, Li G, Shen N, Gong J, Hong X, Yang L, Li H
Cellular & molecular biology letters 2024 May 16;29(1):75
Cellular & molecular biology letters 2024 May 16;29(1):75
Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity.
Liu G, Ma N, Cheng K, Feng Q, Ma X, Yue Y, Li Y, Zhang T, Gao X, Liang J, Zhang L, Wang X, Ren Z, Fu YX, Zhao X, Nie G
Nature nanotechnology 2024 Mar;19(3):387-398
Nature nanotechnology 2024 Mar;19(3):387-398
CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis.
Kent K, Nozawa K, Sutton C, Daniel F, Ikawa M, Garcia TX, Matzuk MM
Andrology 2024 Mar;12(3):682-697
Andrology 2024 Mar;12(3):682-697
Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids.
Yan J, Xiao L, Feng D, Chen B, Yang T, Tong B, Luo R, Wang Y, Chen J
Genes & diseases 2024 Mar;11(2):1066-1081
Genes & diseases 2024 Mar;11(2):1066-1081
Mitotic Spindle Positioning (MISP) Facilitates Colorectal Cancer Progression by Forming a Complex with Opa Interacting Protein 5 (OIP5) and Activating the JAK2-STAT3 Signaling Pathway.
Hiura K, Watanabe M, Hirose N, Nakano K, Okamura T, Sasaki H, Sasaki N
International journal of molecular sciences 2024 Mar 6;25(5)
International journal of molecular sciences 2024 Mar 6;25(5)
Novel Diagnostic Biomarker BST2 Identified by Integrated Transcriptomics Promotes the Development of Endometriosis via the TNF-α/NF-κB Signaling Pathway.
Jiang L, Wang S, Xia X, Zhang T, Wang X, Zeng F, Ma J, Fang X
Biochemical genetics 2024 Mar 5;
Biochemical genetics 2024 Mar 5;
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y
The Journal of cell biology 2024 Mar 4;223(3)
The Journal of cell biology 2024 Mar 4;223(3)
Large-scale RNA-seq mining reveals ciclopirox triggers TDP-43 cryptic exons.
Sinha IR, Sandal PS, Burns GD, Mallika AP, Irwin KE, Cruz ALF, Wang V, Rodríguez JL, Wong PC, Ling JP
bioRxiv : the preprint server for biology 2024 Mar 30;
bioRxiv : the preprint server for biology 2024 Mar 30;
Roseburia intestinalis sensitizes colorectal cancer to radiotherapy through the butyrate/OR51E1/RALB axis.
Dong J, Wang B, Xiao Y, Liu J, Wang Q, Xiao H, Jin Y, Liu Z, Chen Z, Li Y, Fan S, Li Y, Cui M
Cell reports 2024 Mar 26;43(3):113846
Cell reports 2024 Mar 26;43(3):113846
Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA.
Brewer A, Sathe G, Pflug BE, Clarke RG, Macartney TJ, Sapkota GP
iScience 2024 Mar 15;27(3):109302
iScience 2024 Mar 15;27(3):109302
Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer.
Zhao A, Yang J, Ran R, Zhao S, Cui Y, Hu F, Zhou Y
Translational oncology 2024 Jun;44:101960
Translational oncology 2024 Jun;44:101960
Idebenone ameliorates statin-induced myotoxicity in atherosclerotic ApoE-/- mice by reducing oxidative stress and improving mitochondrial function.
Yu W, Wu W, Zhao D, Zhang R, Shao K, Liu H, Yan C, Lin P
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167157
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167157
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.
Wang H, Yuan S, Zheng Q, Zhang S, Zhang Q, Ji S, Wang W, Cao Y, Guo Y, Yang X, Geng H, Yang F, Xi S, Jin G, Zhang J, Gao Q, Bernards R, Qin W, Wang C
Gastroenterology 2024 Jun;166(6):1130-1144.e8
Gastroenterology 2024 Jun;166(6):1130-1144.e8
Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periosti.
Xie W, Gan J, Zhou X, Tian H, Pan X, Liu W, Li X, Du J, Xu A, Zheng M, Wu F, Li Y, Lin Z
Cell metabolism 2024 Jun 4;36(6):1269-1286.e9
Cell metabolism 2024 Jun 4;36(6):1269-1286.e9
Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury.
Dong Y, Liu G, Situ X, Xia L, Zhang T, Zhu X, Jin H, Liu Y, Shou S
Inflammation 2024 Jun 24;
Inflammation 2024 Jun 24;
Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides.
Huang D, Zhu X, Ye S, Zhang J, Liao J, Zhang N, Zeng X, Wang J, Yang B, Zhang Y, Lao L, Chen J, Xin M, Nie Y, Saw PE, Su S, Song E
Nature 2024 Jan;625(7995):593-602
Nature 2024 Jan;625(7995):593-602
CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
Shen M, Wu Y, Li L, Zhang L, Liu G, Wang R
Journal of diabetes 2024 Jan;16(1):e13471
Journal of diabetes 2024 Jan;16(1):e13471
SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair.
Huang Y, Tang M, Hu Z, Cai B, Chen G, Jiang L, Xia Y, Guan P, Li X, Mao Z, Wan X, Lu W
Oncogenesis 2024 Jan 8;13(1):3
Oncogenesis 2024 Jan 8;13(1):3
IL-1β-Stimulated Bone Mesenchymal Stem Cell-Derived Exosomes Mitigate Sepsis through Modulation of HMGB1/AKT Pathway and M2 Macrophage Polarization.
Li Y, Sun Z, Li Y, Sun J, Chen B
Current molecular medicine 2024 Jan 3;
Current molecular medicine 2024 Jan 3;
Rapid and comprehensive metabolites identification of 5-demethylnobiletin in rats using UPLC/Triple-TOF-MS/MS based on multiple mass defect filter and their neuroprotection against ferroptosis.
Yuan S, Gao P, Wu S, Liang X, Xiao Y, Tu P, Jiang Y
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115842
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115842
KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.
Wu T, Cheng AY, Zhang Y, Xu J, Wu J, Wen L, Li X, Liu B, Dou X, Wang P, Zhang L, Fei J, Li J, Ouyang Z, He C
Nature biotechnology 2024 Jan 18;
Nature biotechnology 2024 Jan 18;
Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility†.
Daniel-Carlier N, Castille J, Passet B, Vilotte M, Le Danvic C, Jaffrezic F, Beauvallet C, Péchoux C, Capitan A, Vilotte JL
Biology of reproduction 2024 Jan 13;110(1):78-89
Biology of reproduction 2024 Jan 13;110(1):78-89
Adventitial delivery of miR-145 to treat intimal hyperplasia post vascular injuries through injectable and in-situ self-assembling peptide hydrogels.
Zhao J, Wu S, Zhang M, Hong X, Zhao M, Xu S, Ji J, Ren K, Fu G, Fu J
Acta biomaterialia 2024 Jan 1;173:247-260
Acta biomaterialia 2024 Jan 1;173:247-260
Ceramide enhanced the hepatic glucagon response through regulation of CREB activity.
Wang J, Wang D, Lu S, Hu Y, Ge Y, Qin X, Mo Y, Kan J, Li D, Zhang R, Liu Y, Zhang WS
Clinical nutrition (Edinburgh, Scotland) 2024 Feb;43(2):366-378
Clinical nutrition (Edinburgh, Scotland) 2024 Feb;43(2):366-378
Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice.
Tian XJ, Yin ZJ, Li ZJ, Wang ZZ, Xing Z, Liu CY, Wang LT, Wang CM, Zhang JF, Dong L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2305913
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2305913
UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.
Li Y, Jiang M, Aye L, Luo L, Zhang Y, Xu F, Wei Y, Peng D, He X, Gu J, Yu X, Li G, Ge D, Lu C
Nature communications 2024 Feb 8;15(1):1200
Nature communications 2024 Feb 8;15(1):1200
Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape.
Yang K, Chen G, Yu F, Fang X, Zhang J, Zhang Z, Shi Y, Zhang L
Communications biology 2024 Feb 7;7(1):158
Communications biology 2024 Feb 7;7(1):158
Bleomycin reduces Vairimorpha (Nosema) ceranae infection in honey bees with some evident host toxicity.
Parrella P, Elikan AB, Kogan HV, Wague F, Marshalleck CA, Snow JW
Microbiology spectrum 2024 Feb 6;12(2):e0334923
Microbiology spectrum 2024 Feb 6;12(2):e0334923
IL-8 activates fibroblasts to promote the invasion of HNSCC cells via STAT3-MMP1.
Chen Y, Huang L, Gan RH, Yuan S, Lan T, Zheng D, Lu YG
Cell death discovery 2024 Feb 6;10(1):65
Cell death discovery 2024 Feb 6;10(1):65
Myogenic exosome miR-140-5p modulates skeletal muscle regeneration and injury repair by regulating muscle satellite cells.
Cao X, Xue L, Yu X, Yan Y, Lu J, Luo X, Wang H, Wang J
Aging 2024 Feb 29;16(5):4609-4630
Aging 2024 Feb 29;16(5):4609-4630
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib.
Zhang B, Chen Y, Chen X, Ren Z, Xiang H, Mao L, Zhu G
Cancer cell international 2024 Feb 24;24(1):83
Cancer cell international 2024 Feb 24;24(1):83
The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway.
Suman I, Šimić L, Čanadi Jurešić G, Buljević S, Klepac D, Domitrović R
Cell death discovery 2024 Feb 24;10(1):98
Cell death discovery 2024 Feb 24;10(1):98
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling.
Jia J, Zhu L, Yue X, Tang S, Jing S, Tan C, Du Y, Gao J, Lee I, Qian Y
Cell communication and signaling : CCS 2024 Feb 20;22(1):140
Cell communication and signaling : CCS 2024 Feb 20;22(1):140
Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis.
Dunn TN, Cope DI, Tang S, Sirupangi T, Parks SE, Liao Z, Yuan F, Creighton CJ, Masand RP, Alpuing Radilla L, Guan X, Detti L, Monsivais D, Matzuk MM
Endocrinology 2024 Feb 20;165(4)
Endocrinology 2024 Feb 20;165(4)
Characterization of immunogenic cell death regulators predicts survival and immunotherapy response in lung adenocarcinoma.
Zhou D, Cui Y, Zhu M, Lin Y, Guo J, Li Y, Zhang J, Wu Z, Guo J, Chen Y, Liang W, Lin W, Lei K, Zhao T, You Q
Life sciences 2024 Feb 1;338:122396
Life sciences 2024 Feb 1;338:122396
Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy.
Zhai J, Wang C, Jin L, Liu F, Xiao Y, Gu H, Liu M, Chen Y
Molecular neurobiology 2024 Dec;61(12):9794-9809
Molecular neurobiology 2024 Dec;61(12):9794-9809
Macrocarpal B blocks the binding between the phospholipase A2 receptor and its antibodies.
Feng Z, Guo FS, Wang Q, Wang M, Zhao MH, Cui Z, Lei X
Bioorganic & medicinal chemistry 2024 Aug 1;110:117793
Bioorganic & medicinal chemistry 2024 Aug 1;110:117793
Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.
Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett AM, Diano S, Huang Y
Diabetologia 2024 Apr;67(4):724-737
Diabetologia 2024 Apr;67(4):724-737
M2 macrophage-derived exosomes carry miR-142-3p to restore the differentiation balance of irradiated BMMSCs by targeting TGF-β1.
Huang C, Zhao L, Xiao Y, Tang Z, Jing L, Guo K, Tian L, Zong C
Molecular and cellular biochemistry 2024 Apr;479(4):993-1010
Molecular and cellular biochemistry 2024 Apr;479(4):993-1010
Coptisine inhibits neointimal hyperplasia through attenuating Pak1/Pak2 signaling in vascular smooth muscle cells without retardation of re-endothelialization.
Chen Y, Jiang X, Yuan Y, Chen Y, Wei S, Yu Y, Zhou Q, Yu Y, Wang J, Liu H, Hua X, Yang Z, Chen Z, Li Y, Wang Q, Chen J, Wang Y
Atherosclerosis 2024 Apr;391:117480
Atherosclerosis 2024 Apr;391:117480
Age-Related Gut Microbiota Transplantation Disrupts Myocardial Energy Homeostasis and Induces Oxidative Damage.
Xu H, Li O, Kim D, Yang F, Bao Z
The Journal of nutrition 2024 Apr;154(4):1189-1199
The Journal of nutrition 2024 Apr;154(4):1189-1199
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
Qian Z, Xia M, Zhao T, Li Y, Li G, Zhang Y, Li H, Yang L
Clinical and translational medicine 2024 Apr;14(4):e1661
Clinical and translational medicine 2024 Apr;14(4):e1661
Schisandrin A alleviates renal fibrosis by inhibiting PKCβ and oxidative stress.
Liu HL, Huang Z, Li QZ, Cao YZ, Wang HY, Alolgab RN, Deng XY, Zhang ZH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155372
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155372
Co-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis.
Wang Y, Peng Y, Zi G, Chen J, Peng B
Scientific reports 2024 Apr 6;14(1):8095
Scientific reports 2024 Apr 6;14(1):8095
PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis.
Zhang L, Nie F, Zhao J, Li S, Liu W, Guo H, Yang P
Journal of translational medicine 2024 Apr 30;22(1):407
Journal of translational medicine 2024 Apr 30;22(1):407
Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets.
Zhao D, Guo Y, Wei H, Jia X, Zhi Y, He G, Nie W, Huang L, Wang P, Laster KV, Liu Z, Wang J, Lee MH, Dong Z, Liu K
JCI insight 2024 Apr 23;9(10)
JCI insight 2024 Apr 23;9(10)
Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation.
Du R, Xiao N, Han L, Guo K, Li K, Chen Z, Zhang H, Zhou Z, Huang Y, Zhao X, Bian H
Scientific reports 2024 Apr 22;14(1):9167
Scientific reports 2024 Apr 22;14(1):9167
GDF9(His209GlnfsTer6/S428T) and GDF9(Q321X/S428T) bi-allelic variants caused female subfertility with defective follicle enlargement.
Duan Y, Cai B, Guo J, Wang C, Mai Q, Xu Y, Zeng Y, Shi Y, Wang B, Ding C, Chen M, Zhou C, Xu Y
Cell communication and signaling : CCS 2024 Apr 20;22(1):235
Cell communication and signaling : CCS 2024 Apr 20;22(1):235
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.
Yu L, Wan Q, Liu Q, Fan Y, Zhou Q, Skowronski AA, Wang S, Shao Z, Liao CY, Ding L, Kennedy BK, Zha S, Que J, LeDuc CA, Sun L, Wang L, Qiang L
Cell metabolism 2024 Apr 2;36(4):793-807.e5
Cell metabolism 2024 Apr 2;36(4):793-807.e5
The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression.
Nie F, Zhang J, Tian H, Zhao J, Gong P, Wang H, Wang S, Yang P, Yang C
Cell death & disease 2024 Apr 18;15(4):277
Cell death & disease 2024 Apr 18;15(4):277
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Wang M, Liu Y, Gui H, Ma G, Li B, Zhang Z, Yu G, Wu A, Xu X, Zhang D
European journal of pharmacology 2024 Apr 15;969:176303
European journal of pharmacology 2024 Apr 15;969:176303
Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease.
Huang X, Qi J, Su Y, Zhou Y, Wang Q, Huang T, Xue D, Zeng Y, Verkhratsky A, Zhou B, Chen H, Yi C
Cell death & disease 2024 Apr 12;15(4):258
Cell death & disease 2024 Apr 12;15(4):258
Ferrostatin-1 mitigates ionizing radiation-induced intestinal injuries by inhibiting apoptosis and ferroptosis: an in vitro and in vivo study.
Wang X, Li W, Dong Y, Zhang Y, Huo Q, Lu L, Zhang J, Zhao Y, Fan S, Dong H, Li D
International journal of radiation biology 2023;99(10):1607-1618
International journal of radiation biology 2023;99(10):1607-1618
Electric field promotes dermal fibroblast transdifferentiation through activation of RhoA/ROCK1 pathway.
Wang W, Huang W, Liu J, Zhang Z, Ji R, Wu C, Zhang J, Jiang X
International journal of medical sciences 2023;20(10):1326-1335
International journal of medical sciences 2023;20(10):1326-1335
Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.
Zhang L, Huang J, Dai L, Zhu G, Yang XL, He Z, Li YH, Yang H, Zhang CQ, Shen KF, Liang P
Frontiers in neurology 2023;14:1255097
Frontiers in neurology 2023;14:1255097
Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer.
Zhang B, Ren Z, Zhao J, Zhu Y, Huang B, Xiao C, Zhang Y, Deng J, Mao L, Tang L, Lan D, Gao L, Zhang H, Chen G, Luo OJ
Theranostics 2023;13(13):4449-4468
Theranostics 2023;13(13):4449-4468
Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis.
Zhang R, Chen S, Yang Z, Zhang N, Guo K, Lv K, Zhou Z, Gao M, Hu X, Su Y, He J, Wang F
Burns & trauma 2023;11:tkad038
Burns & trauma 2023;11:tkad038
Electroacupuncture alleviated depression-like behaviors in ventromedial prefrontal cortex of chronic unpredictable mild stress-induced rats: Increasing synaptic transmission and phosphorylating dopamine transporter.
Cai X, Wu M, Zhang Z, Liu H, Huang S, Song J, Ren S, Huang Y
CNS neuroscience & therapeutics 2023 Sep;29(9):2608-2620
CNS neuroscience & therapeutics 2023 Sep;29(9):2608-2620
Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
Hou H, Chen Y, Feng X, Xu G, Yan M
Molecular medicine reports 2023 Sep;28(3)
Molecular medicine reports 2023 Sep;28(3)
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Fang Z, Li Y, Wang J, Wang X, Huang L, Sun L, Deng Q
Biological trace element research 2023 Sep;201(9):4437-4446
Biological trace element research 2023 Sep;201(9):4437-4446
Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ.
Liu F, Li S, Chen P, Gu Y, Wang S, Wang L, Chen C, Wang R, Yuan Y
International immunopharmacology 2023 Sep;122:110550
International immunopharmacology 2023 Sep;122:110550
hESC-Derived Epicardial Cells Promote Repair of Infarcted Hearts in Mouse and Swine.
Luo XL, Jiang Y, Li Q, Yu XJ, Ma T, Cao H, Ke MX, Zhang P, Tan JL, Gong YS, Wang L, Gao L, Yang HT
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2300470
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2300470
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
Zhang F, Zhang B, Ding H, Li X, Wang X, Zhang X, Liu Q, Feng Q, Han M, Chen L, Qi L, Yang D, Li X, Zhu X, Zhao Q, Qiu J, Zhu Z, Tang H, Shen N, Wang H, Wei B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2207108
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2207108
Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss.
Zhou X, Jin L, Li Y, Wang Y, Li W, Shen X
BMC genomics 2023 Sep 27;24(1):577
BMC genomics 2023 Sep 27;24(1):577
Identification of VPS34-PI(3)P-FEN1-mediated DNA repair pathway as a potential drug target to overcome chemoresistance.
Zhang X, Dan S, Pan X, Li J, Wei Q, Huang L, Kang B, Chen C
Biochemical and biophysical research communications 2023 Sep 24;674:27-35
Biochemical and biophysical research communications 2023 Sep 24;674:27-35
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis.
Wang B, Liang Z, Tan T, Zhang M, Jiang Y, Shang Y, Gao X, Song S, Wang R, Chen H, Liu J, Li J, Ren Y, Liu P
eLife 2023 Sep 22;12
eLife 2023 Sep 22;12
A combination of 5/6-nephrectomy and unilateral ureteral obstruction model accelerates progression of remote organ fibrosis in chronic kidney disease.
Homma K, Enoki Y, Uchida S, Taguchi K, Matsumoto K
FASEB bioAdvances 2023 Oct;5(10):377-394
FASEB bioAdvances 2023 Oct;5(10):377-394
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.
Yao Y, Cao Y, Xu Y, Chen G, Liu Y, Jiang H, Fan R, Qin W, Wang X, Chai H, Chen X, Qiu Z, Chen W
The Canadian journal of cardiology 2023 Oct;39(10):1449-1462
The Canadian journal of cardiology 2023 Oct;39(10):1449-1462
Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism.
Gan PXL, Liao W, Lim HF, Wong WSF
Pharmacological research 2023 Oct;196:106929
Pharmacological research 2023 Oct;196:106929
Evaluation of the radiosensitizing effect of MEK inhibitor KZ-001 on non-small cell lung cancer cells in vitro.
Huang G, Zhang W, Tian H
Asian biomedicine : research, reviews and news 2023 Oct;17(5):230-237
Asian biomedicine : research, reviews and news 2023 Oct;17(5):230-237
Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction proteins and the TRPA1 modulation.
Lai YH, Chiang YF, Huang KC, Chen HY, Ali M, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115334
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115334
Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.
Yang T, Shi X, Li S, Zhao Z, Wang J, Yu P, Li H, Wang R, Chen Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115314
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115314
Targeted inhibition of BET proteins in HPV-16 associated head and neck squamous cell carcinoma reveals heterogeneous transcription response.
Rao A, Ni Z, Suresh D, Mohanty C, Wang AR, Lee DL, Nickel KP, Varambally SRJ, Lambert PF, Kendziorski C, Iyer G
bioRxiv : the preprint server for biology 2023 Oct 4;
bioRxiv : the preprint server for biology 2023 Oct 4;
Chimpanzee adenovirus-mediated multiple gene therapy for age-related macular degeneration.
Wei-Zhang S, Cui B, Xing M, Liu J, Guo Y, He K, Bai T, Dong X, Lei Y, Zhou W, Zhou H, Liu S, Wang X, Zhou D, Yan H
iScience 2023 Oct 20;26(10):107939
iScience 2023 Oct 20;26(10):107939
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein.
Bosnakovski D, Toso EA, Ener ET, Gearhart MD, Yin L, Lüttmann FF, Magli A, Shi K, Kim J, Aihara H, Kyba M
iScience 2023 Oct 20;26(10):107823
iScience 2023 Oct 20;26(10):107823
Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups.
Lobón-Iglesias MJ, Andrianteranagna M, Han ZY, Chauvin C, Masliah-Planchon J, Manriquez V, Tauziede-Espariat A, Turczynski S, Bouarich-Bourimi R, Frah M, Dufour C, Blauwblomme T, Cardoen L, Pierron G, Maillot L, Guillemot D, Reynaud S, Bourneix C, Pouponnot C, Surdez D, Bohec M, Baulande S, Delattre O, Piaggio E, Ayrault O, Waterfall JJ, Servant N, Beccaria K, Dangouloff-Ros V, Bourdeaut F
Nature communications 2023 Oct 20;14(1):6669
Nature communications 2023 Oct 20;14(1):6669
Lycorine promotes IDH1 acetylation to induce mitochondrial dynamics imbalance in colorectal cancer cells.
Zhuo FF, Li L, Liu TT, Liang XM, Yang Z, Zheng YZ, Luo QW, Lu JH, Liu D, Zeng KW, Tu PF
Cancer letters 2023 Oct 1;573:216364
Cancer letters 2023 Oct 1;573:216364
An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity.
Wu T, Liu C, Zou S, Lyu R, Yang B, Yan H, Zhao M, Tang W
Nature chemical biology 2023 Nov;19(11):1384-1393
Nature chemical biology 2023 Nov;19(11):1384-1393
Assigning functionality to cysteines by base editing of cancer dependency genes.
Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, Cravatt BF
Nature chemical biology 2023 Nov;19(11):1320-1330
Nature chemical biology 2023 Nov;19(11):1320-1330
Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer.
Chen HY, Lin CE, Wu SC, Yang ZY, Chiang YF, Huang KC, Wang KL, Ali M, Shieh TM, Chang HY, Huang TC, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115533
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115533
Towards modular engineering of cell signalling: Topographically-textured microparticles induce osteogenesis via activation of canonical hedgehog signalling.
Ghuloum FI, Stevens LA, Johnson CA, Riobo-Del Galdo NA, Amer MH
Biomaterials advances 2023 Nov;154:213652
Biomaterials advances 2023 Nov;154:213652
Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8(+) T cells.
He W, Wang X, Chen M, Li C, Chen W, Pan L, Cui Y, Yu Z, Wu G, Yang Y, Xu M, Dong Z, Ma K, Wang J, He Z
Clinical and translational medicine 2023 Nov;13(11):e1465
Clinical and translational medicine 2023 Nov;13(11):e1465
Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti-Tumor Immunity.
Ma H, Fang W, Li Q, Wang Y, Hou SX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2305089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Nov;10(32):e2305089
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase.
Yu T, Nie S, Bu L, Liu M, He J, Niu X, Feng H, Guo J, Tang B, Zhang Z, Ye K, Jiang H, Chen L, Zhang Z
JCI insight 2023 Nov 8;8(21)
JCI insight 2023 Nov 8;8(21)
ATAD1 inhibits hepatitis C virus infection by removing the viral TA-protein NS5B from mitochondria.
Zhou Q, Yang Y, Xu Z, Deng K, Zhang Z, Hao J, Li N, Wang Y, Wang Z, Chen H, Yang Y, Xiao F, Zhang X, Gao S, Li YP
EMBO reports 2023 Nov 6;24(11):e56614
EMBO reports 2023 Nov 6;24(11):e56614
Compound 5 alleviated acute kidney injury without affecting the antitumor effect after cisplatin treatment.
Guo Y, Li X, Yuan R, Ren J, Huang Y, Tian H
Biochemical and biophysical research communications 2023 Nov 5;680:177-183
Biochemical and biophysical research communications 2023 Nov 5;680:177-183
KZ02 enhances the radiosensitivity of BRAF-mutated CRC in vitro and in vivo.
Guo Y, Li X, Yuan R, Ren J, Huang Y, Yu Y, Tian H
European journal of pharmacology 2023 Nov 15;959:176060
European journal of pharmacology 2023 Nov 15;959:176060
Camk2a suppresses denervated muscle atrophy by maintaining the Ca2+ homeostasis in muscle cells.
Zhang Y, Xia M, Zhao T, Zhang Q, Li R, Yang L
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Nov 15;69(11):25-29
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Nov 15;69(11):25-29
Acetyl-CoA Acetyltransferase 2 Confers Radioresistance by Inhibiting Ferroptosis in Esophageal Squamous Cell Carcinoma.
Heng J, Li Z, Liu L, Zheng Z, Zheng Y, Xu X, Liao L, Xu H, Huang H, Li E, Xu L
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
International journal of radiation oncology, biology, physics 2023 Nov 15;117(4):966-978
Melatonin ameliorates histone modification disorders in mammalian aged oocytes by neutralizing the alkylation of HDAC1.
He Y, Gao M, Yang W, Sun S, Wang Q, Gu L
Free radical biology & medicine 2023 Nov 1;208:361-370
Free radical biology & medicine 2023 Nov 1;208:361-370
Gigaxonin is required for intermediate filament transport.
Renganathan B, Zewe JP, Cheng Y, Paumier JM, Kittisopikul M, Ridge KM, Opal P, Gelfand VI
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22886
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22886
An A-kinase anchoring protein (ACBD3) coordinates traffic-induced PKA activation at the Golgi.
Jia J, Tang S, Yue X, Jing S, Zhu L, Tan C, Gao J, Du Y, Lee I, Qian Y
The Journal of biological chemistry 2023 May;299(5):104696
The Journal of biological chemistry 2023 May;299(5):104696
Microglial P2Y12 Signaling Contributes to Cisplatin-induced Pain Hypersensitivity via IL-18-mediated Central Sensitization in the Spinal Cord.
Chen XT, Chen LP, Fan LJ, Kan HM, Wang ZZ, Qian B, Pan ZQ, Shen W
The journal of pain 2023 May;24(5):901-917
The journal of pain 2023 May;24(5):901-917
Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders.
Lv J, Hu Y, Li L, He Y, Wang J, Guo N, Fang Y, Chen Q, Cai C, Tong J, Tang L, Wang Z
Metabolism: clinical and experimental 2023 May;142:155528
Metabolism: clinical and experimental 2023 May;142:155528
Hypolipidemic and Anti-Inflammatory Effects of Curcuma longa-Derived Bisacurone in High-Fat Diet-Fed Mice.
He C, Miyazawa T, Abe C, Ueno T, Suzuki M, Mizukami M, Kurihara K, Toda M
International journal of molecular sciences 2023 May 27;24(11)
International journal of molecular sciences 2023 May 27;24(11)
Deletion of Arrb2 Down-regulates Autophagy in the Mouse Hippocampus via Akt-mTOR Pathway Activation.
Peng Q, Liu Y, Yu L, Shen Y, Li F, Feng S, Chen F
Neuroscience 2023 May 21;519:120-130
Neuroscience 2023 May 21;519:120-130
Nogo-B deficiency suppresses white adipogenesis by regulating β-catenin signaling.
Li J, Sun Y, Xue C, Yang X, Duan Y, Zhao D, Han J
Life sciences 2023 May 15;321:121571
Life sciences 2023 May 15;321:121571
Bmi-1 Overexpression Improves Sarcopenia Induced by 1,25(OH)(2) D(3) Deficiency and Downregulates GATA4-Dependent Rela Transcription.
Wang Q, Zhao J, Chen H, Zhou J, Chen A, Zhang J, Wang Y, Mao Z, Wang J, Qiu X, Chen Y, Wang R, Zhang Y, Miao D, Jin J
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Mar;38(3):427-442
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Mar;38(3):427-442
Inherent Capability of Self-Assembling Nanostructures in Specific Proteasome Activation for Cancer Cell Pyroptosis.
Luo QW, Yao L, Li L, Yang Z, Zhao MM, Zheng YZ, Zhuo FF, Liu TT, Zhang XW, Liu D, Tu PF, Zeng KW
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(9):e2205531
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(9):e2205531
Human MD2 deficiency-an inborn error of immunity with pleiotropic features.
Li Y, Yu Z, Schenk M, Lagovsky I, Illig D, Walz C, Rohlfs M, Conca R, Muise AM, Snapper SB, Uhlig HH, Garty BZ, Klein C, Kotlarz D
The Journal of allergy and clinical immunology 2023 Mar;151(3):791-796.e7
The Journal of allergy and clinical immunology 2023 Mar;151(3):791-796.e7
Identification of novel NFKB1 and ICOS frameshift variants in patients with CVID.
Liu A, Liu Q, Leng S, Zhang X, Feng Q, Peng J, Feng G
Clinical and experimental immunology 2023 Mar 8;211(1):68-77
Clinical and experimental immunology 2023 Mar 8;211(1):68-77
Effect of dermatopontin on osteogenic differentiation of periodontal ligament stem cells.
Zhao X, Xie Z, Rao N, Zhang S, Zhang Y
Gene 2023 Mar 30;858:147185
Gene 2023 Mar 30;858:147185
NUSAP1 Binds ILF2 to Modulate R-Loop Accumulation and DNA Damage in Prostate Cancer.
Chiu CL, Li CG, Verschueren E, Wen RM, Zhang D, Gordon CA, Zhao H, Giaccia AJ, Brooks JD
International journal of molecular sciences 2023 Mar 26;24(7)
International journal of molecular sciences 2023 Mar 26;24(7)
Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by suppressing leucine-related mTORC1 signaling and reducing oxidative stress.
Wei P, He Q, Liu T, Zhang J, Shi K, Zhang J, Liu S
Journal of ethnopharmacology 2023 Mar 25;304:116095
Journal of ethnopharmacology 2023 Mar 25;304:116095
The Regulation of ZIP8 by Dietary Manganese in Mice.
Yu S, Zhao N
International journal of molecular sciences 2023 Mar 22;24(6)
International journal of molecular sciences 2023 Mar 22;24(6)
The Effect of Cholesterol Efflux on Endothelial Dysfunction Caused by Oxidative Stress.
Ye H, Liu Q, Wang Y, Zhen X, Yan N
International journal of molecular sciences 2023 Mar 21;24(6)
International journal of molecular sciences 2023 Mar 21;24(6)
CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasis.
Zhang B, Ren Z, Zheng H, Lin M, Chen G, Luo OJ, Zhu G
iScience 2023 Mar 17;26(3):106099
iScience 2023 Mar 17;26(3):106099
The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma.
Besse L, Kraus M, Besse A, Driessen C, Tarantino I
Scientific reports 2023 Mar 17;13(1):4411
Scientific reports 2023 Mar 17;13(1):4411
CD8+ T cell-Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance.
Lao L, Zeng W, Huang P, Chen H, Jia Z, Wang P, Huang D, Chen J, Nie Y, Yang L, Wu W, Liu J
Cancer immunology research 2023 Mar 1;11(3):320-338
Cancer immunology research 2023 Mar 1;11(3):320-338
TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate.
Miura M, Sakaue F, Matsuno H, Morita K, Yoshida A, Hara RI, Nishimura R, Nishida Y, Yokogawa M, Osawa M, Yokota T
FEBS letters 2023 Jun;597(12):1667-1676
FEBS letters 2023 Jun;597(12):1667-1676
Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinoma.
Du R, Li K, Zhou Z, Huang Y, Guo K, Zhang H, Chen Z, Zhao X, Han L, Bian H
Oncology reports 2023 Jun;49(6)
Oncology reports 2023 Jun;49(6)
"Untargeting" autoantibodies using genome editing, a proof-of-concept study.
Keppeke GD, Diogenes L, Gomes K, Andrade LEC
Clinical immunology (Orlando, Fla.) 2023 Jun;251:109343
Clinical immunology (Orlando, Fla.) 2023 Jun;251:109343
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.
Hu X, Zou R, Zhang Z, Ji J, Li J, Huo XY, Liu D, Ge MX, Cui MK, Wu MZ, Li ZP, Wang Q, Zhang X, Zhang ZR
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Jun;1866(2):194937
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Jun;1866(2):194937
HSPA5, as a ferroptosis regulator, may serve as a potential therapeutic for head and neck squamous cell carcinoma.
Li J, Xiao W, Wei W, Wu M, Xiong K, Lyu J, Li Y
Molecular immunology 2023 Jun;158:79-90
Molecular immunology 2023 Jun;158:79-90
Sunitinib attenuates reactive MDSCs enhancing anti-tumor immunity in HNSCC.
Liu J, Lin WP, Su W, Wu ZZ, Yang QC, Wang S, Sun TG, Huang CF, Wang XL, Sun ZJ
International immunopharmacology 2023 Jun;119:110243
International immunopharmacology 2023 Jun;119:110243
Differential intracellular trafficking of extracellular vesicles in microglia and astrocytes.
Pantazopoulou M, Lamprokostopoulou A, Karampela DS, Alexaki A, Delis A, Coens A, Samiotaki M, Kriebardis AG, Melki R, Pagakis SN, Stefanis L, Vekrellis K
Cellular and molecular life sciences : CMLS 2023 Jun 30;80(7):193
Cellular and molecular life sciences : CMLS 2023 Jun 30;80(7):193
Chemotherapeutic drugs-induced pyroptosis mediated by gasdermin E promotes the progression and chemoresistance of pancreatic cancer.
Li S, Yue M, Xu H, Zhang X, Mao T, Quan M, Ma J, Wang Y, Ge W, Wang Y, Xue S, Shentu D, Cui J, Wang L
Cancer letters 2023 Jun 28;564:216206
Cancer letters 2023 Jun 28;564:216206
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O
Journal of ovarian research 2023 Jun 27;16(1):122
Journal of ovarian research 2023 Jun 27;16(1):122
DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice.
Zhang WB, Huang Y, Guo XR, Zhang MQ, Yuan XS, Zu HB
Acta neuropathologica communications 2023 Jun 21;11(1):102
Acta neuropathologica communications 2023 Jun 21;11(1):102
Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.
Yang QC, Wang S, Liu YT, Song A, Wu ZZ, Wan SC, Li HM, Sun ZJ
iScience 2023 Jun 16;26(6):106916
iScience 2023 Jun 16;26(6):106916
An In Vivo CRISPR Screen Identifies That SNRPC Promotes Triple-Negative Breast Cancer Progression.
Lu XX, Yang WX, Pei YC, Luo H, Li XG, Wang YJ, Zhang GL, Ling H, Shao ZM, Hu X
Cancer research 2023 Jun 15;83(12):2000-2015
Cancer research 2023 Jun 15;83(12):2000-2015
Role of ADAM33 short isoform as a tumor suppressor in the pathogenesis of thyroid cancer via oncogenic function disruption of full-length ADAM33.
Lan J, Zhou Y, Liu Y, Xia Y, Wan Y, Cao J
Human cell 2023 Jul;36(4):1451-1463
Human cell 2023 Jul;36(4):1451-1463
PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
Shang H, Xu A, Yan H, Xu D, Zhang J, Fang X
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):763-776
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):763-776
LncRNA INPP5F ameliorates stress-induced hypertension via the miR-335/Cttn axis in rostral ventrolateral medulla.
Zhang S, Chen G, Wang X, Tong L, Wang L, Liu T, Zhu L, Zhou S, Liu H, Du D
CNS neuroscience & therapeutics 2023 Jul;29(7):1830-1847
CNS neuroscience & therapeutics 2023 Jul;29(7):1830-1847
PDZD8-mediated endoplasmic reticulum-mitochondria associations regulate sympathetic drive and blood pressure through the intervention of neuronal mitochondrial homeostasis in stress-induced hypertension.
Liu T, Wang L, Chen G, Tong L, Ye X, Yang H, Liu H, Zhang H, Lu W, Zhang S, Du D
Neurobiology of disease 2023 Jul;183:106173
Neurobiology of disease 2023 Jul;183:106173
Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway.
Zheng J, Wang S, Zhang T, Li H, Zhu M, Wei X, Ge Y, Yang X, Zhang S, Xu H, Duan Y, Liu L, Chen Y
International immunopharmacology 2023 Jul;120:110378
International immunopharmacology 2023 Jul;120:110378
Hierarchically Injectable Hydrogel Sequentially Delivers AntagomiR-467a-3p-Loaded and AntagomiR-874-5p-Loaded Satellite-Cell-Targeting Bioengineered Extracellular Vesicles Attenuating Sarcopenia.
Dai H, Luo J, Deng L, Song C, Deng Z, Wu Y, Gu S, Xu J
Advanced healthcare materials 2023 Jul;12(17):e2203056
Advanced healthcare materials 2023 Jul;12(17):e2203056
Conoidin A, a Covalent Inhibitor of Peroxiredoxin 2, Reduces Growth of Glioblastoma Cells by Triggering ROS Production.
Szeliga M, Rola R
Cells 2023 Jul 26;12(15)
Cells 2023 Jul 26;12(15)
Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles.
Beusch I, Rao B, Studer MK, Luhovska T, Šukytė V, Lei S, Oses-Prieto J, SeGraves E, Burlingame A, Jonas S, Madhani HD
Molecular cell 2023 Jul 20;83(14):2578-2594.e9
Molecular cell 2023 Jul 20;83(14):2578-2594.e9
Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model.
Sutton C, Nozawa K, Kent K, Saltzman A, Leng M, Nagarajan S, Malovannaya A, Ikawa M, Garcia TX, Matzuk MM
Scientific reports 2023 Jul 14;13(1):11374
Scientific reports 2023 Jul 14;13(1):11374
Hepatic DKK1-driven steatosis is CD36 dependent.
Yang Z, Huang X, Zhang J, You K, Xiong Y, Fang J, Getachew A, Cheng Z, Yu X, Wang Y, Wu F, Wang N, Feng S, Lin X, Yang F, Chen Y, Wei H, Li YX
Life science alliance 2023 Jan;6(1)
Life science alliance 2023 Jan;6(1)
p53 downregulates PD-L1 expression via miR-34a to inhibit the growth of triple-negative breast cancer cells: a potential clinical immunotherapeutic target.
Deng S, Wang M, Wang C, Zeng Y, Qin X, Tan Y, Liang B, Cao Y
Molecular biology reports 2023 Jan;50(1):577-587
Molecular biology reports 2023 Jan;50(1):577-587
De Novo Somatic Mosaicism of CYBB Caused by Intronic LINE-1 Element Insertion Resulting in Chronic Granulomatous Disease.
Yu L, Li W, Lv G, Sun G, Yang L, Chen J, Zhou L, Ding Y, Zhang Z, Tang X, An Y, Zhao X
Journal of clinical immunology 2023 Jan;43(1):88-100
Journal of clinical immunology 2023 Jan;43(1):88-100
CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype.
Zeng W, Xiong L, Wu W, Li S, Liu J, Yang L, Lao L, Huang P, Zhang M, Chen H, Miao N, Lin Z, Liu Z, Yang X, Wang J, Wang P, Song E, Yao Y, Nie Y, Chen J, Huang D
Oncogene 2023 Jan;42(3):224-237
Oncogene 2023 Jan;42(3):224-237
The novel sustained 3-hydroxybutyrate donor poly-D-3-hydroxybutyric acid prevents inflammatory bowel disease through upregulation of regulatory T-cells.
Suzuki R, Mishima M, Nagane M, Mizugaki H, Suzuki T, Komuro M, Shimizu T, Fukuyama T, Takeda S, Ogata M, Miyamoto T, Aihara N, Kamiie J, Kamisuki S, Yokaryo H, Yamashita T, Satoh T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22708
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22708
IKKα aggravates renal fibrogenesis by positively regulating the Wnt/β-catenin pathway.
Zhang H, Pan B, Huang W, Ma M, Zhang F, Jiang L, Qian C, Wan X, Cao C
Immunology 2023 Jan;168(1):120-134
Immunology 2023 Jan;168(1):120-134
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.
He Y, B'nai Taub A, Yu L, Yao Y, Zhang R, Zahr T, Aaron N, LeSauter J, Fan L, Liu L, Tazebay R, Que J, Pajvani U, Wang L, Silver R, Qiang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2204190
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(2):e2204190
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
He W, Cheng Z, Huo Z, Lin B, Wang X, Sun Y, Yu S, Cao S, Xue J, Liu R, Lv W, Li Y, Hong S, Xiao H
Endocrinology 2023 Jan 9;164(3)
Endocrinology 2023 Jan 9;164(3)
Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability.
Caballero-Ruiz B, Gkotsi DS, Ollerton H, Morales-Alcala CC, Bordone R, Jenkins GML, Di Magno L, Canettieri G, Riobo-Del Galdo NA
Cancers 2023 Jan 6;15(2)
Cancers 2023 Jan 6;15(2)
Lactate metabolism is essential in early-onset mitochondrial myopathy.
Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P
Science advances 2023 Jan 4;9(1):eadd3216
Science advances 2023 Jan 4;9(1):eadd3216
PCIF1-mediated deposition of 5'-cap N(6),2'-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection.
Wang L, Wang S, Wu L, Li W, Bray W, Clark AE, Gonzalez GM, Wang Y, Carlin AF, Rana TM
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 31;120(5):e2210361120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 31;120(5):e2210361120
Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis.
Lin Y, Dai H, Yu G, Song C, Liu J, Xu J
Journal of orthopaedic surgery and research 2023 Jan 30;18(1):73
Journal of orthopaedic surgery and research 2023 Jan 30;18(1):73
Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.
Wang L, Wu L, Zhu Z, Zhang Q, Li W, Gonzalez GM, Wang Y, Rana TM
The EMBO journal 2023 Jan 16;42(2):e111673
The EMBO journal 2023 Jan 16;42(2):e111673
Polycationic PAMAM ameliorates obesity-associated chronic inflammation and focal adiposity.
Huang B, Wan Q, Li T, Yu L, Du W, Calhoun C, Leong KW, Qiang L
Biomaterials 2023 Feb;293:121850
Biomaterials 2023 Feb;293:121850
miRNA‑92a inhibits vascular smooth muscle cell phenotypic modulation and may help prevent in‑stent restenosis.
Jiang F, Zhang B, Zhang X, Zhang R, Lu Q, Shi F, Xu J, Deng L
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Liang X, Wei Y, Hou X, Guo Q, Liang H, Zeng K, Tu P, Zhang Q
Phytochemistry 2023 Feb;206:113530
Phytochemistry 2023 Feb;206:113530
Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening.
Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM
Journal of medicinal chemistry 2023 Feb 9;66(3):2143-2160
Journal of medicinal chemistry 2023 Feb 9;66(3):2143-2160
Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.
Kong LR, Chen XH, Sun Q, Zhang KY, Xu L, Ding L, Zhou YP, Zhang ZB, Lin JR, Gao PJ
Cell reports 2023 Feb 28;42(2):112078
Cell reports 2023 Feb 28;42(2):112078
Genetic background strongly influences the transition to chronic kidney disease of adriamycin nephropathy in mice.
Watanabe M, Hiura K, Sasaki H, Okamura T, Sasaki N
Experimental animals 2023 Feb 21;72(1):47-54
Experimental animals 2023 Feb 21;72(1):47-54
PSAT1 positively regulates the osteogenic lineage differentiation of periodontal ligament stem cells through the ATF4/PSAT1/Akt/GSK3β/β-catenin axis.
Jia L, Li D, Wang YN, Zhang D, Xu X
Journal of translational medicine 2023 Feb 2;21(1):70
Journal of translational medicine 2023 Feb 2;21(1):70
BRPF1 bridges H3K4me3 and H3K23ac in human embryonic stem cells and is essential to pluripotency.
Zhang C, Lin H, Zhang Y, Xing Q, Zhang J, Zhang D, Liu Y, Chen Q, Zhou T, Wang J, Shan Y, Pan G
iScience 2023 Feb 17;26(2):105939
iScience 2023 Feb 17;26(2):105939
Effect of Zbed6 Single-Allele Knockout on the Growth and Development of Skeletal Muscle in Mice.
Liu L, Wang S, Tian W, Xu C, Wei C, Cui K, Jiang L, Wang D
Biology 2023 Feb 17;12(2)
Biology 2023 Feb 17;12(2)
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
Hu Y, Jiang H, Xu Y, Chen G, Fan R, Zhou Y, Liu Y, Yao Y, Liu R, Chen W, Zhang K, Chen X, Wang R, Qiu Z
Cell death discovery 2023 Feb 14;9(1):63
Cell death discovery 2023 Feb 14;9(1):63
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P, Perret M, Liu Z, Jordan I, Elmas Bozdemir S, Bayhan GI, Beaufils C, Bizien L, Bisiaux A, Lei W, Hasan M, Chen J, Gaughan C, Asthana A, Libri V, Luna JM, Jaffré F, Hoffmann HH, Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flores C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Le Voyer T, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T, Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumadó V, DeDiego ML, Fidouh N, Rozenberg F, Pérez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval X, CoV-Contact Cohort§, COVID Human Genetic Effort¶, Pan-Hammarström Q, Planas AM, Meyts I, Haerynck F, Pujol A, Sancho-Shimizu V, Dalgard CL, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Béziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton RP, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL
Science (New York, N.Y.) 2023 Feb 10;379(6632):eabo3627
Science (New York, N.Y.) 2023 Feb 10;379(6632):eabo3627
Mitotic spindle positioning protein (MISP) deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis in mice.
Hiura K, Maruyama T, Watanabe M, Nakano K, Okamura T, Sasaki H, Sasaki N
The Journal of veterinary medical science 2023 Feb 1;85(2):167-174
The Journal of veterinary medical science 2023 Feb 1;85(2):167-174
The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice.
Qin X, Xie C, Hakenjos JM, MacKenzie KR, Boyd SR, Barzi M, Bissig KD, Young DW, Li F
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023 Feb 1;181:106358
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023 Feb 1;181:106358
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production.
Song J, Lv H, Liu B, Hao M, Taylor HS, Zhang X, Li D, Huang Y
Molecular metabolism 2023 Dec;78:101828
Molecular metabolism 2023 Dec;78:101828
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y
Redox biology 2023 Dec;68:102944
Redox biology 2023 Dec;68:102944
A novel homozygous Y140X mutation of ISG15 causes diverse type I interferonopathies in sibling patients with cutaneous lesions or recurrent parenchymal pneumonia.
Xu Q, Li W, Zhao Q, Zhao L, Lv G, Sun G, Gao Y, Ding Y, Zhang Z, Zhou L, Chen Y, Tang X, Zhu J, Zhao X, An Y
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109844
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109844
METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis.
Chen Y, Wu Y, Fang L, Zhao H, Xu S, Shuai Z, Yu H, Cai G, Zhan HQ, Pan F
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109838
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109838
Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
Chen Y, Li Q, Zhao S, Sun L, Yin Z, Wang X, Li X, Iwakiri Y, Han J, Duan Y
Biochemical pharmacology 2023 Dec;218:115928
Biochemical pharmacology 2023 Dec;218:115928
GmPLP1 negatively regulates soybean resistance to high light stress by modulating photosynthetic capacity and reactive oxygen species accumulation in a blue light-dependent manner.
Zhang Y, Zheng J, Zhan Y, Yu Z, Liu S, Lu X, Li Y, Li Z, Liang X, Li H, Feng Y, Teng W, Li W, Han Y, Zhao X, Li Y
Plant biotechnology journal 2023 Dec;21(12):2625-2640
Plant biotechnology journal 2023 Dec;21(12):2625-2640
The pterostilbene-dihydropyrazole derivative Ptd-1 ameliorates vascular calcification by regulating inflammation.
Wei X, Shen Z, Zhu M, Fang M, Wang S, Zhang T, Zhang B, Yang X, Lv Z, Duan Y, Jiang M, Ma C, Li Q, Chen Y
International immunopharmacology 2023 Dec;125(Pt B):111198
International immunopharmacology 2023 Dec;125(Pt B):111198
BPTF Drives Gastric Cancer Resistance to EGFR Inhibitor by Epigenetically Regulating the C-MYC/PLCG1/Perk Axis.
Li F, Yu J, Pan T, Feng H, Li J, Yu B, Fan Z, Sang Q, Chen M, Zang M, Hou J, Wu X, Yu Y, Li YY, Yan C, Zhu Z, Su L, Liu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2303091
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2303091
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
CREB1 Facilitates GABAergic Neural Differentiation of Human Mesenchymal Stem Cells through BRN2 for Pain Alleviation and Locomotion Recovery after Spinal Cord Injury.
Kao Y, Zhu H, Yang Y, Shen W, Song W, Zhang R, Liu Y, Liu H, Kong X
Cells 2023 Dec 28;13(1)
Cells 2023 Dec 28;13(1)
Choroid plexus mast cells drive tumor-associated hydrocephalus.
Li Y, Di C, Song S, Zhang Y, Lu Y, Liao J, Lei B, Zhong J, Guo K, Zhang N, Su S
Cell 2023 Dec 21;186(26):5719-5738.e28
Cell 2023 Dec 21;186(26):5719-5738.e28
Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Zhu C, Zhou Q, Wang Z, Zhang J, Xu C, Ruan D
Molecular biology reports 2023 Aug;50(8):6337-6347
Molecular biology reports 2023 Aug;50(8):6337-6347
Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease.
Wang M, Gong K, Zhu X, Chen S, Zhou J, Zhang H, Han J, Ma L, Duan Y
MedComm 2023 Aug;4(4):e320
MedComm 2023 Aug;4(4):e320
Single amino acid-based PROTACs trigger degradation of the oncogenic kinase BCR-ABL in chronic myeloid leukemia (CML).
Zhang J, Ma C, Yu Y, Liu C, Fang L, Rao H
The Journal of biological chemistry 2023 Aug;299(8):104994
The Journal of biological chemistry 2023 Aug;299(8):104994
Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin.
Deng DX, Li CY, Zheng ZY, Wen B, Liao LD, Zhang XJ, Li EM, Xu LY
Molecular & cellular proteomics : MCP 2023 Aug;22(8):100593
Molecular & cellular proteomics : MCP 2023 Aug;22(8):100593
Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy.
Tran QTN, Gan PXL, Liao W, Mok YK, Chai CLL, Wong WSF
Pharmacological research 2023 Aug;194:106861
Pharmacological research 2023 Aug;194:106861
Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition.
Wang X, Sun Z, Yang T, Lin F, Ye S, Yan J, Li T, Chen J
mSystems 2023 Aug 31;8(4):e0041523
mSystems 2023 Aug 31;8(4):e0041523
OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer.
Xie X, Laster KV, Li J, Nie W, Yi YW, Liu K, Seong YS, Dong Z, Kim DJ
Cellular and molecular life sciences : CMLS 2023 Aug 30;80(9):272
Cellular and molecular life sciences : CMLS 2023 Aug 30;80(9):272
Haspin balances the ratio of asymmetric cell division through Wnt5a and regulates cell fate decisions in mouse embryonic stem cells.
Gao Y, Ma B, Li Y, Wu X, Zhao S, Guo H, Wang Y, Sun L, Xie J
Cell death discovery 2023 Aug 23;9(1):307
Cell death discovery 2023 Aug 23;9(1):307
XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
Kuang M, Zhao Y, Yu H, Li S, Liu T, Chen L, Chen J, Luo Y, Guo X, Wei X, Li Y, Zhang Z, Wang D, You F
Science advances 2023 Aug 18;9(33):eadg5211
Science advances 2023 Aug 18;9(33):eadg5211
Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to -4) Using a Newly Developed DENV-3 Infectious Clone and Replicon.
Hu M, Li WF, Wu T, Yang Y, Chen G, Chen T, Liu Y, Mei Y, Wu D, Wei Y, Luo T, Zhang HJ, Li YP
Microbiology spectrum 2023 Aug 17;11(4):e0042323
Microbiology spectrum 2023 Aug 17;11(4):e0042323
Expression and function of patatin-like phospholipase domain-containing 2 in cleft palate induced by retinoic acid.
Ye QN, Zheng K
The British journal of oral & maxillofacial surgery 2023 Apr;61(3):215-220
The British journal of oral & maxillofacial surgery 2023 Apr;61(3):215-220
A neuron-specific Isca1 knockout rat developments multiple mitochondrial dysfunction syndromes.
Sheng H, Lu D, Qi X, Ling Y, Li J, Zhang X, Dong W, Chen W, Gao S, Gao X, Zhang L, Zhang L
Animal models and experimental medicine 2023 Apr;6(2):155-167
Animal models and experimental medicine 2023 Apr;6(2):155-167
Effects of Helicobacter pylori on the expression of the FTO gene and its biological role in gastric cancer.
Gui S, Wang Q, Bao L, He X, Wang Z, Liu L, Wu L, Zhao Y, Zhou J, Xie Y
Oncology letters 2023 Apr;25(4):143
Oncology letters 2023 Apr;25(4):143
Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities.
Wang J, Wang D, Feng L, Li X, Gong Y, Wang Z, Tan N, Han J
Phytochemistry 2023 Apr;208:113603
Phytochemistry 2023 Apr;208:113603
Conserved NIMA kinases regulate multiple steps of endocytic trafficking.
Joseph BB, Naslavsky N, Binti S, Conquest S, Robison L, Bai G, Homer RO, Grant BD, Caplan S, Fay DS
PLoS genetics 2023 Apr;19(4):e1010741
PLoS genetics 2023 Apr;19(4):e1010741
NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).
Hao J, Li J, Zhang Z, Yang Y, Zhou Q, Wu T, Chen T, Wu Z, Zhang P, Cui J, Li YP
Autophagy 2023 Apr;19(4):1332-1347
Autophagy 2023 Apr;19(4):1332-1347
KDEL Receptor Trafficking to the Plasma Membrane Is Regulated by ACBD3 and Rab4A-GTP.
Tan C, Du Y, Zhu L, Jing S, Gao J, Qian Y, Yue X, Lee I
Cells 2023 Apr 4;12(7)
Cells 2023 Apr 4;12(7)
Gomisin D alleviates liver fibrosis through targeting PDGFRβ in hepatic stellate cells.
Wang R, Liu F, Chen P, Li S, Gu Y, Wang L, Chen C, Yuan Y
International journal of biological macromolecules 2023 Apr 30;235:123639
International journal of biological macromolecules 2023 Apr 30;235:123639
A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns.
Tang Y, Han Y, Zhao J, Lv Y, Fan C, Zheng L, Zhang Z, Liu Z, Li C, Lin Y
Nano-micro letters 2023 Apr 30;15(1):112
Nano-micro letters 2023 Apr 30;15(1):112
FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.
Yang YS, Liu MH, Yan ZW, Chen GQ, Huang Y
Stem cells (Dayton, Ohio) 2023 Apr 25;41(4):354-367
Stem cells (Dayton, Ohio) 2023 Apr 25;41(4):354-367
A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model.
Lv H, Catarino J, Li D, Liu B, Gao XB, Horvath TL, Huang Y
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 18;120(16):e2300015120
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 18;120(16):e2300015120
Syndecan-1 as an immunogene in Triple-negative breast cancer: regulation tumor-infiltrating lymphocyte in the tumor microenviroment and EMT by TGFb1/Smad pathway.
Zhong Y, Li F, Zhang S, Yang Z, Ren X, Cao X, Xu Y, Guo D, Zhou Y, Mao F, Shen S, Sun Q
Cancer cell international 2023 Apr 17;23(1):76
Cancer cell international 2023 Apr 17;23(1):76
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
Wen B, Deng DX, Liao LD, Zhang ZD, Zheng YQ, Dong K, Xu LY, Li EM
Biomedicines 2023 Apr 16;11(4)
Biomedicines 2023 Apr 16;11(4)
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Tan L, Qi X, Kong W, Jin J, Lu D, Zhang X, Wang Y, Wang S, Dong W, Shi X, Chen W, Wang J, Li K, Xie Y, Gao L, Guan F, Gao K, Li C, Wang C, Hu Z, Zhang L, Guo X, Shen B, Ma Y
Science advances 2023 Apr 14;9(15):eadf2695
Science advances 2023 Apr 14;9(15):eadf2695
Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer.
Chen A, Xu M, Chen J, Chen T, Wang Q, Zhang R, Qiu J
BioMed research international 2022;2022:6207701
BioMed research international 2022;2022:6207701
Artemin Promotes the Migration and Invasion of Cervical Cancer Cells through AKT/mTORC1 Signaling.
Zhu M, Zhou L, Fu J, Wang Y, Xu X, Wu J, Kong X, Li J, Zhou Z, Zhou H
Journal of oncology 2022;2022:3332485
Journal of oncology 2022;2022:3332485
Elevated FOXA1 Expression Indicates Poor Prognosis in Liver Cancer due to Its Effects on Cell Proliferation and Metastasis.
Liu Z, Wang Y, Aizimuaji Z, Ma S, Xiao T
Disease markers 2022;2022:3317315
Disease markers 2022;2022:3317315
Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.
Qian Z, Chen H, Xia M, Chang J, Li X, Ye S, Wu S, Jiang S, Bao J, Wang B, Kong R, Zhang S, Zheng S, Cao X, Hong X
International journal of biological sciences 2022;18(4):1328-1346
International journal of biological sciences 2022;18(4):1328-1346
Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.
Jiang F, Xia M, Zhang Y, Chang J, Cao J, Zhang Z, Qian Z, Yang L
Frontiers in immunology 2022;13:993168
Frontiers in immunology 2022;13:993168
Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis.
Wang C, Ma H, Zhang B, Hua T, Wang H, Wang L, Han L, Li Q, Wu W, Sun Y, Yang H, Lu X
Frontiers in immunology 2022;13:963582
Frontiers in immunology 2022;13:963582
Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1.
Cao Y, Yang L, Cheng H
Frontiers in pharmacology 2022;13:941094
Frontiers in pharmacology 2022;13:941094
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Sun J, Wei J, Zhang Y, Li J, Li J, Yan J, Guo M, Han J, Qiao H
Frontiers in immunology 2022;13:819680
Frontiers in immunology 2022;13:819680
Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy.
Ueno D, Vasquez JC, Sule A, Liang J, van Doorn J, Sundaram R, Friedman S, Caliliw R, Ohtake S, Bao X, Li J, Ye H, Boyd K, Huang RR, Dodson J, Boutros P, Bindra RS, Shuch B
Oncotarget 2022;13:1054-1067
Oncotarget 2022;13:1054-1067
Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis.
Ghosh S, Singh R, Vanwinkle ZM, Guo H, Vemula PK, Goel A, Haribabu B, Jala VR
Theranostics 2022;12(12):5574-5595
Theranostics 2022;12(12):5574-5595
A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C.
West G, Turunen M, Aalto A, Virtanen L, Li SP, Heliö T, Meinander A, Taimen P
Frontiers in cell and developmental biology 2022;10:932983
Frontiers in cell and developmental biology 2022;10:932983
Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.
Wang H, Cui Y, Gong H, Xu J, Huang S, Tang A
Frontiers in bioengineering and biotechnology 2022;10:929979
Frontiers in bioengineering and biotechnology 2022;10:929979
Ruxolitinib attenuates secondary injury after traumatic spinal cord injury.
Qian ZY, Kong RY, Zhang S, Wang BY, Chang J, Cao J, Wu CQ, Huang ZY, Duan A, Li HJ, Yang L, Cao XJ
Neural regeneration research 2022 Sep;17(9):2029-2035
Neural regeneration research 2022 Sep;17(9):2029-2035
MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer.
Gao Y, Fang Y, Huang Y, Ma R, Chen X, Wang F, Pei X, Gao Y, Chen X, Liu X, Shan J, Li P
Cell death & disease 2022 Sep 21;13(9):810
Cell death & disease 2022 Sep 21;13(9):810
Pangenomic analysis of Chinese gastric cancer.
Yu Y, Zhang Z, Dong X, Yang R, Duan Z, Xiang Z, Li J, Li G, Yan F, Xue H, Jiao D, Lu J, Lu H, Zhang W, Wei Y, Fan S, Li J, Jia J, Zhang J, Ji J, Liu P, Lu H, Zhao H, Chen S, Wei C, Chen H, Zhu Z
Nature communications 2022 Sep 15;13(1):5412
Nature communications 2022 Sep 15;13(1):5412
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.
Monterisi S, Michl J, Hulikova A, Koth J, Bridges EM, Hill AE, Abdullayeva G, Bodmer WF, Swietach P
eLife 2022 Sep 15;11
eLife 2022 Sep 15;11
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.
Bondi CD, Rush BM, Hartman HL, Wang J, Al-Bataineh MM, Hughey RP, Tan RJ
Antioxidants (Basel, Switzerland) 2022 Sep 14;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 14;11(9)
E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma.
Chen M, Zhao Z, Wu L, Huang J, Yu P, Qian J, Ni T, Zhao C
Cell death & disease 2022 Sep 12;13(9):784
Cell death & disease 2022 Sep 12;13(9):784
Suppression of macrophage-mediated xenogeneic rejection by the ectopic expression of human CD177.
Kogata S, Lo PC, Maeda A, Okamatsu C, Sato K, Yamamoto R, Haneda T, Yoneyama T, Toyama C, Eguchi H, Masahata K, Kamiyama M, Okuyama H, Miyagawa S
Transplant immunology 2022 Oct;74:101663
Transplant immunology 2022 Oct;74:101663
A non-metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11-mediated CD133 stability.
Wang J, Shao F, Yang Y, Wang W, Yang X, Li R, Cheng H, Sun S, Feng X, Gao Y, He J, Lu Z
Cancer communications (London, England) 2022 Oct;42(10):1008-1027
Cancer communications (London, England) 2022 Oct;42(10):1008-1027
Autoregulation of H(+)/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.
Blaszczak W, Williams H, Swietach P
British journal of cancer 2022 Oct;127(7):1365-1377
British journal of cancer 2022 Oct;127(7):1365-1377
Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.
Xia M, Zhang Y, Wu H, Zhang Q, Liu Q, Li G, Zhao T, Liu X, Zheng S, Qian Z, Li H
International immunopharmacology 2022 Oct;111:109120
International immunopharmacology 2022 Oct;111:109120
Identification of SLC3A2 as a Potential Therapeutic Target of Osteoarthritis Involved in Ferroptosis by Integrating Bioinformatics, Clinical Factors and Experiments.
Liu H, Deng Z, Yu B, Liu H, Yang Z, Zeng A, Fu M
Cells 2022 Oct 30;11(21)
Cells 2022 Oct 30;11(21)
Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.
Pan L, Li C, Meng L, Tian Y, He M, Yuan X, Zhang G, Zhang Z, Xiong J, Chen G, Zhang Z
Brain : a journal of neurology 2022 Oct 21;145(10):3454-3471
Brain : a journal of neurology 2022 Oct 21;145(10):3454-3471
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Zhou W, Wu WH, Si ZL, Liu HL, Wang H, Jiang H, Liu YF, Alolga RN, Chen C, Liu SJ, Bian XY, Shan JJ, Li J, Tan NH, Zhang ZH
Nature communications 2022 Oct 14;13(1):6081
Nature communications 2022 Oct 14;13(1):6081
Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome.
Wei Z, Shimizu K, Sarii RS, Muthusinghe DS, Lokupathirage SMW, Nio-Kobayashi J, Yoshimatsu K
Viruses 2022 Oct 13;14(10)
Viruses 2022 Oct 13;14(10)
Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice.
Chen HY, Hong YH, Chiang YF, Wang KL, Huang TC, Ali M, Shieh TM, Chang HY, Hsia SM
Metabolites 2022 Oct 12;12(10)
Metabolites 2022 Oct 12;12(10)
Excessive activation of HOXB13/PIMREG axis promotes hepatocellular carcinoma progression and drug resistance.
Tang C, Qiu S, Mou W, Xu J, Wang P
Biochemical and biophysical research communications 2022 Oct 1;623:81-88
Biochemical and biophysical research communications 2022 Oct 1;623:81-88
Coronin2A links actin-based endosomal processes to the EHD1 fission machinery.
Dhawan K, Naslavsky N, Caplan S
Molecular biology of the cell 2022 Oct 1;33(12):ar107
Molecular biology of the cell 2022 Oct 1;33(12):ar107
Genetic and Functional Identifying of Novel STAT1 Loss-of-Function Mutations in Patients with Diverse Clinical Phenotypes.
Chen X, Chen J, Chen R, Mou H, Sun G, Yang L, Jia Y, Zhao Q, Wen W, Zhou L, Ding Y, Tang X, Yang J, An Y, Zhao X
Journal of clinical immunology 2022 Nov;42(8):1778-1794
Journal of clinical immunology 2022 Nov;42(8):1778-1794
Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability.
Hong S, Xie Y, Cheng Z, Li J, He W, Guo Z, Zhang Q, Peng S, He M, Yu S, Xu L, Liu R, Xu T, Zhang Y, Li Y, Wang J, Lv W, Yu J, Xiao H
Oncogene 2022 Nov;41(47):5121-5132
Oncogene 2022 Nov;41(47):5121-5132
Tp47 promoted the phagocytosis of HMC3 cells though autophagy induced by endoplamic reticlum stress.
Li W, Li QL, Xu QY, Wang XT, Yang TC
Journal of the European Academy of Dermatology and Venereology : JEADV 2022 Nov;36(11):2224-2234
Journal of the European Academy of Dermatology and Venereology : JEADV 2022 Nov;36(11):2224-2234
Combined Therapy of Low-Dose Angiotensin Receptor-Neprilysin Inhibitor and Sodium-Glucose Cotransporter-2 Inhibitor Prevents Doxorubicin-Induced Cardiac Dysfunction in Rodent Model with Minimal Adverse Effects.
Kim D, Jang G, Hwang J, Wei X, Kim H, Son J, Rhee SJ, Yun KH, Oh SK, Oh CM, Park R
Pharmaceutics 2022 Nov 28;14(12)
Pharmaceutics 2022 Nov 28;14(12)
Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors.
Fan Y, Zhang Y, Shi K, Cheng S, Pei D, Shu X
Cell death & disease 2022 Nov 26;13(11):1000
Cell death & disease 2022 Nov 26;13(11):1000
Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer.
Chen X, Luo R, Zhang Y, Ye S, Zeng X, Liu J, Huang D, Liu Y, Liu Q, Luo ML, Song E
Nature communications 2022 Nov 22;13(1):7160
Nature communications 2022 Nov 22;13(1):7160
Deficiency of CD93 exacerbates inflammation-induced activation and migration of BV2 microglia by regulating the TAK1/NF-κB pathway.
Hong X, Xia M, Zhang Q, Zhao T, Zhang Y, Qian Z, Bao J, Li H
Neuroscience letters 2022 Nov 20;791:136914
Neuroscience letters 2022 Nov 20;791:136914
CD16(+) fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition.
Liu X, Lu Y, Huang J, Xing Y, Dai H, Zhu L, Li S, Feng J, Zhou B, Li J, Xia Q, Li J, Huang M, Gu Y, Su S
Cancer cell 2022 Nov 14;40(11):1341-1357.e13
Cancer cell 2022 Nov 14;40(11):1341-1357.e13
Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo.
Chen HY, Chiang YF, Hong YH, Shieh TM, Huang TC, Ali M, Chang HY, Wang KL, Hsia SM
Antioxidants (Basel, Switzerland) 2022 Nov 13;11(11)
Antioxidants (Basel, Switzerland) 2022 Nov 13;11(11)
Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.
Wilson AD, Richards MA, Curtis MK, Gunadasa-Rohling M, Monterisi S, Loonat AA, Miller JJ, Ball V, Lewis A, Tyler DJ, Moshnikova A, Andreev OA, Reshetnyak YK, Carr C, Swietach P
Cardiovascular research 2022 Nov 10;118(14):2946-2959
Cardiovascular research 2022 Nov 10;118(14):2946-2959
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Tang K, Qin W, Wei R, Jiang Y, Fan L, Wang Z, Tan N
Pharmacological research 2022 May;179:106123
Pharmacological research 2022 May;179:106123
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
Wang J, Wang Y, Wang J, Zhang S, Yu Z, Zheng K, Fu Z, Wang C, Huang W, Chen J
Bioengineered 2022 May;13(5):13970-13985
Bioengineered 2022 May;13(5):13970-13985
Defining the Skeletal Myogenic Lineage in Human Pluripotent Stem Cell-Derived Teratomas.
Pappas MP, Xie N, Penaloza JS, Chan SSK
Cells 2022 May 9;11(9)
Cells 2022 May 9;11(9)
Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins.
Buchou C, Laud-Duval K, van der Ent W, Grossetête S, Zaidi S, Gentric G, Corbé M, Müller K, Del Nery E, Surdez D, Delattre O
Cancers 2022 May 8;14(9)
Cancers 2022 May 8;14(9)
Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.
Xiang G, Ying K, Jiang P, Jia M, Sun Y, Li S, Wu X, Hao S
Skeletal muscle 2022 May 6;12(1):10
Skeletal muscle 2022 May 6;12(1):10
Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice.
Ren J, Huang R, Li Y, Chen R, Tian H, Liu C
Scientific reports 2022 May 19;12(1):8419
Scientific reports 2022 May 19;12(1):8419
Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.
Cheng Y, Shen Z, Gao Y, Chen F, Xu H, Mo Q, Chu X, Peng CL, McKenzie TT, Palacios BE, Hu J, Zhou H, Long J
Nature communications 2022 May 18;13(1):2724
Nature communications 2022 May 18;13(1):2724
The retromer complex regulates C. elegans development and mammalian ciliogenesis.
Xie S, Dierlam C, Smith E, Duran R, Williams A, Davis A, Mathew D, Naslavsky N, Iyer J, Caplan S
Journal of cell science 2022 May 15;135(10)
Journal of cell science 2022 May 15;135(10)
Direct targeting of amplified gene loci for proapoptotic anticancer therapy.
Kaushik Tiwari M, Colon-Rios DA, Tumu HCR, Liu Y, Quijano E, Krysztofiak A, Chan C, Song E, Braddock DT, Suh HW, Saltzman WM, Rogers FA
Nature biotechnology 2022 Mar;40(3):325-334
Nature biotechnology 2022 Mar;40(3):325-334
Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.
Kaneko T, Horiuchi K, Chijimatsu R, Mori D, Nagata K, Omata Y, Yano F, Inui H, Moro T, Tanaka S, Saito T
Journal of bone and mineral metabolism 2022 Mar;40(2):196-207
Journal of bone and mineral metabolism 2022 Mar;40(2):196-207
CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.
Michl J, Wang Y, Monterisi S, Blaszczak W, Beveridge R, Bridges EM, Koth J, Bodmer WF, Swietach P
Cell reports 2022 Mar 8;38(10):110493
Cell reports 2022 Mar 8;38(10):110493
Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.
Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P
Basic research in cardiology 2022 Mar 31;117(1):17
Basic research in cardiology 2022 Mar 31;117(1):17
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.
Wang H, Lv D, Jiang S, Hou Q, Zhang L, Li S, Zhu X, Xu X, Wen J, Zeng C, Zhang M, Yang F, Chen Z, Zheng C, Li J, Zen K, Liu Z, Li L
Cell death & disease 2022 Mar 29;13(3):281
Cell death & disease 2022 Mar 29;13(3):281
Sexual dimorphic impacts of systemic vincristine on lower urinary tract function.
Iguchi N, Hecht SL, Gao D, Wilcox DT, Malykhina AP, Cost NG
Scientific reports 2022 Mar 24;12(1):5113
Scientific reports 2022 Mar 24;12(1):5113
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Zheng X, Xiao J, Jiang Q, Zheng L, Liu C, Dong C, Zheng Y, Ni P, Zhang C, Zhang F, Zhong R, Ding H, Wang Q, Qiu Y, Gao M, Ding J, Shen N, Wei B, Wang H
The EMBO journal 2022 Mar 15;41(6):e108016
The EMBO journal 2022 Mar 15;41(6):e108016
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L
Redox biology 2022 Jun;52:102292
Redox biology 2022 Jun;52:102292
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Wang Y, Jin C, Tian H, Xu J, Chen J, Hu S, Li Q, Lu L, Ou Q, Xu GT, Cui H
Experimental eye research 2022 Jun;219:108939
Experimental eye research 2022 Jun;219:108939
Up-regulation of miR-335 and miR-674-3p in the rostral ventrolateral medulla contributes to stress-induced hypertension.
Zhang S, Xing M, Chen G, Tong L, Zhang H, Du D
Journal of neurochemistry 2022 Jun;161(5):387-404
Journal of neurochemistry 2022 Jun;161(5):387-404
Pervasive translation of circular RNAs driven by short IRES-like elements.
Fan X, Yang Y, Chen C, Wang Z
Nature communications 2022 Jun 29;13(1):3751
Nature communications 2022 Jun 29;13(1):3751
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.
Watamura N, Sato K, Shiihashi G, Iwasaki A, Kamano N, Takahashi M, Sekiguchi M, Mihira N, Fujioka R, Nagata K, Hashimoto S, Saito T, Ohshima T, Saido TC, Sasaguri H
Science advances 2022 Jun 10;8(23):eabm6155
Science advances 2022 Jun 10;8(23):eabm6155
The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice.
Fung CK, Zhao N
International journal of molecular sciences 2022 Jun 10;23(12)
International journal of molecular sciences 2022 Jun 10;23(12)
MEK1/2 inhibitors induce class I alcohol dehydrogenase (ADH1) expression by regulating farnesoid X receptor in hepatic cell lines and C57BL/6J mouse.
Wang X, Yang Y, Chen Y, Duan Y, Han J, Yang X
Molecular biology reports 2022 Jul;49(7):5843-5852
Molecular biology reports 2022 Jul;49(7):5843-5852
Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis.
Jones T, Naslavsky N, Caplan S
Traffic (Copenhagen, Denmark) 2022 Jul;23(7):360-373
Traffic (Copenhagen, Denmark) 2022 Jul;23(7):360-373
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice.
Tian Y, Pan L, Yuan X, Xiong M, Zhang Z, Meng L, Zheng Y, Bu L, Xu X, Zhang Z
Neurobiology of disease 2022 Jul;169:105736
Neurobiology of disease 2022 Jul;169:105736
Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.
Zhang Q, Wang S, Li W, Yau E, Hui H, Singh PK, Achuthan V, Young Karris MA, Engelman AN, Rana TM
Nucleic acids research 2022 Jul 8;50(12):6687-6701
Nucleic acids research 2022 Jul 8;50(12):6687-6701
Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.
Campbell TM, Liu Z, Zhang Q, Moncada-Velez M, Covill LE, Zhang P, Alavi Darazam I, Bastard P, Bizien L, Bucciol G, Lind Enoksson S, Jouanguy E, Karabela ŞN, Khan T, Kendir-Demirkol Y, Arias AA, Mansouri D, Marits P, Marr N, Migeotte I, Moens L, Ozcelik T, Pellier I, Sendel A, Şenoğlu, S, Shahrooei M, Smith CIE, Vandernoot I, Willekens K, Kart Yaşar K, COVID Human Genetic Effort, Bergman P, Abel L, Cobat A, Casanova JL, Meyts I, Bryceson YT
The Journal of experimental medicine 2022 Jul 4;219(7)
The Journal of experimental medicine 2022 Jul 4;219(7)
C-type lectin domain-containing protein CLEC3A regulates proliferation, regeneration and maintenance of nucleus pulposus cells.
Chen X, Ji Y, Feng F, Liu Z, Qian L, Shen H, Lao L
Cellular and molecular life sciences : CMLS 2022 Jul 21;79(8):435
Cellular and molecular life sciences : CMLS 2022 Jul 21;79(8):435
FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.
Zhang Z, Xu Y
Molecular medicine (Cambridge, Mass.) 2022 Jul 19;28(1):82
Molecular medicine (Cambridge, Mass.) 2022 Jul 19;28(1):82
DSCAM-AS1 Long Non-Coding RNA Exerts Oncogenic Functions in Endometrial Adenocarcinoma via Activation of a Tumor-Promoting Transcriptome Profile.
Treeck O, Weber F, Fritsch J, Skrzypczak M, Schüler-Toprak S, Buechler C, Ortmann O
Biomedicines 2022 Jul 18;10(7)
Biomedicines 2022 Jul 18;10(7)
UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity via modulating unfolded protein response.
Guo B, Xu X, Shao M, Yang X, He G, Qi K, Gu J, Wang L
Biochemical and biophysical research communications 2022 Jul 12;613:207-213
Biochemical and biophysical research communications 2022 Jul 12;613:207-213
PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1.
Kant S, Tran KV, Kvandova M, Caliz AD, Yoo HJ, Learnard H, Dolan AC, Craige SM, Hall JD, Jiménez JM, St Hilaire C, Schulz E, Kröller-Schön S, Keaney JF Jr
Arteriosclerosis, thrombosis, and vascular biology 2022 Jan;42(1):19-34
Arteriosclerosis, thrombosis, and vascular biology 2022 Jan;42(1):19-34
CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway.
Huang C, Du R, Jia X, Liu K, Qiao Y, Wu Q, Yao N, Yang L, Zhou L, Liu X, Xiang P, Xin M, Wang Y, Chen X, Kim DJ, Dong Z, Li X
Cell death and differentiation 2022 Jan;29(1):14-27
Cell death and differentiation 2022 Jan;29(1):14-27
Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
Yi T, Chen H, Zhan J, Li Y, Long Z, Wu Z, Yang M, Peng T, Li H
Experimental biology and medicine (Maywood, N.J.) 2022 Jan;247(2):165-173
Experimental biology and medicine (Maywood, N.J.) 2022 Jan;247(2):165-173
LRRK2 is required for CD38-mediated NAADP-Ca(2+) signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Nabar NR, Heijjer CN, Shi CS, Hwang IY, Ganesan S, Karlsson MCI, Kehrl JH
Autophagy 2022 Jan;18(1):204-222
Autophagy 2022 Jan;18(1):204-222
Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma.
Nishino K, Nishiko Y, Shibata M, Oda Y, Watanabe E, Niimi K, Yamamoto E, Kajiyama H
Placenta 2022 Jan;117:109-117
Placenta 2022 Jan;117:109-117
Proteomic analysis of opossum Monodelphis domestica spinal cord reveals the changes of proteins related to neurodegenerative diseases during developmental period when neuroregeneration stops being possible.
Tomljanović I, Petrović A, Ban J, Mladinic M
Biochemical and biophysical research communications 2022 Jan 8;587:85-91
Biochemical and biophysical research communications 2022 Jan 8;587:85-91
Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Dixit D, Prager BC, Gimple RC, Miller TE, Wu Q, Yomtoubian S, Kidwell RL, Lv D, Zhao L, Qiu Z, Zhang G, Lee D, Park DE, Wechsler-Reya RJ, Wang X, Bao S, Rich JN
Science translational medicine 2022 Jan 5;14(626):eabf3917
Science translational medicine 2022 Jan 5;14(626):eabf3917
Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.
Wang J, Zhou L, Chen B, Yu Z, Zhang J, Zhang Z, Hu C, Bai Y, Ruan X, Wang S, Ouyang J, Wu A, Zhao X
Journal of translational medicine 2022 Jan 31;20(1):58
Journal of translational medicine 2022 Jan 31;20(1):58
Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.
Liang R, Tong X, Dong Z, Qin W, Fan L, Bai Z, Zhang Z, Xiang T, Wang Z, Tan N
Journal of ethnopharmacology 2022 Jan 30;283:114664
Journal of ethnopharmacology 2022 Jan 30;283:114664
RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80.
Tian Q, Gao H, Zhou Y, Zhu L, Yang J, Wang B, Liu P, Yang J
Cell death & disease 2022 Jan 21;13(1):71
Cell death & disease 2022 Jan 21;13(1):71
The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.
Popek M, Bobula B, Orzeł-Gajowik K, Zielińska M
International journal of molecular sciences 2022 Jan 19;23(3)
International journal of molecular sciences 2022 Jan 19;23(3)
Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
Shi S, Buck TM, Nickerson AJ, Brodsky JL, Kleyman TR
American journal of physiology. Cell physiology 2022 Jan 1;322(1):C111-C121
American journal of physiology. Cell physiology 2022 Jan 1;322(1):C111-C121
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability.
Zhang N, Shen Y, Li H, Chen Y, Zhang P, Lou S, Deng J
Experimental & molecular medicine 2022 Feb;54(2):194-205
Experimental & molecular medicine 2022 Feb;54(2):194-205
Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
Wang X, Yang Y, Zhao D, Zhang S, Chen Y, Chen Y, Feng K, Li X, Han J, Iwakiri Y, Duan Y, Yang X
The Journal of biological chemistry 2022 Feb;298(2):101561
The Journal of biological chemistry 2022 Feb;298(2):101561
Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification.
Guo Q, Zhang YC, Wang W, Wang YQ, Liu Y, Yang Z, Zhao MM, Feng N, Wang YH, Zhang XW, Yang H, Liu TT, Shi LY, Shi XM, Liu D, Tu PF, Zeng KW
Pharmacological research 2022 Feb;176:106046
Pharmacological research 2022 Feb;176:106046
Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition.
Mo S, Fang D, Zhao S, Thai Hoa PT, Zhou C, Liang T, He Y, Yu T, Chen Y, Qin W, Han Q, Su H, Zhu G, Luo X, Peng T, Han C
Annals of translational medicine 2022 Feb;10(3):151
Annals of translational medicine 2022 Feb;10(3):151
Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice.
Chen Y, Zhou Y, Li XC, Ma X, Mi WL, Chu YX, Wang YQ, Mao-Ying QL
Biological research 2022 Feb 3;55(1):5
Biological research 2022 Feb 3;55(1):5
Effects of the Water Extract of Fermented Rice Bran on Liver Damage and Intestinal Injury in Aged Rats with High-Fat Diet Feeding.
Chen TY, Chen YL, Chiu WC, Yeh CL, Tung YT, Shirakawa H, Liao WT, Yang SC
Plants (Basel, Switzerland) 2022 Feb 24;11(5)
Plants (Basel, Switzerland) 2022 Feb 24;11(5)
The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2.
Suthapot P, Xiao T, Felsenfeld G, Hongeng S, Wongtrakoongate P
Life sciences 2022 Feb 15;291:120298
Life sciences 2022 Feb 15;291:120298
Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.
Sen A, Prager BC, Zhong C, Park D, Zhu Z, Gimple RC, Wu Q, Bernatchez JA, Beck S, Clark AE, Siqueira-Neto JL, Rich JN, McVicker G
Cancer research 2022 Feb 1;82(3):377-390
Cancer research 2022 Feb 1;82(3):377-390
Hypoxic preconditioning promotes galvanotaxis of human dermal microvascular endothelial cells through NF-κB pathway.
Zhang Z, Wu C, Yang J, Liu J, Yi Li, Liu L, Kong M, Zhang J, Jiang X
Heliyon 2022 Dec;8(12):e12421
Heliyon 2022 Dec;8(12):e12421
Single-cell transcriptional profiling reveals heterogeneity and developmental trajectories of Ewing sarcoma.
Hong B, Li Y, Yang R, Dai S, Zhan Y, Zhang WB, Dong R
Journal of cancer research and clinical oncology 2022 Dec;148(12):3267-3280
Journal of cancer research and clinical oncology 2022 Dec;148(12):3267-3280
Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR.
Wang R, Li S, Chen P, Yue X, Wang S, Gu Y, Yuan Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154435
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154435
VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.
Li J, Huang D, Lei B, Huang J, Yang L, Nie M, Su S, Zhao Q, Wang Y
eLife 2022 Dec 9;11
eLife 2022 Dec 9;11
Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.
Fan R, Jiang H, Hu Y, Xu Y, Zhou Y, Chen G, Liu Y, Yao Y, Qin W, Chen W, Huang F, Chen X
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):112-120
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):112-120
Genome-Wide Analysis of Circular RNAs Reveals circCHRNG Regulates Sheep Myoblast Proliferation via miR-133/SRF and MEF2A Axis.
Liu Y, Chen Q, Bao J, Pu Y, Han J, Zhao H, Ma Y, Zhao Q
International journal of molecular sciences 2022 Dec 16;23(24)
International journal of molecular sciences 2022 Dec 16;23(24)
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
Resveratrol activates the SIRT1/PGC-1 pathway in mice to improve synaptic-related cognitive impairment after TBI.
Yu D, Zhao XY, Meng QP, Teng D, Deng K, Lin N
Brain research 2022 Dec 1;1796:148109
Brain research 2022 Dec 1;1796:148109
The DEAD-box helicase DDX3x ameliorates non-alcoholic fatty liver disease via mTORC1 signalling pathway.
Liu P, Zhang Y, Tang C, Cen L, Chen Y, Li S, Chen X, Yu M, Zhang J, Zhang X, Zeng H, Xu C, Yu C
Liver international : official journal of the International Association for the Study of the Liver 2022 Aug;42(8):1793-1802
Liver international : official journal of the International Association for the Study of the Liver 2022 Aug;42(8):1793-1802
Spirulina phycocyanin extract and its active components suppress epithelial-mesenchymal transition process in endometrial cancer via targeting TGF-beta1/SMAD4 signaling pathway.
Chen HY, Chiang YF, Huang CY, Shieh TM, Kao C, Chang FK, Huang TC, Ali M, Chang HY, Hong YH, Hsia SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113219
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113219
Rational Design and Optimization of m(6)A-RNA Demethylase FTO Inhibitors as Anticancer Agents.
Huff S, Kummetha IR, Zhang L, Wang L, Bray W, Yin J, Kelley V, Wang Y, Rana TM
Journal of medicinal chemistry 2022 Aug 25;65(16):10920-10937
Journal of medicinal chemistry 2022 Aug 25;65(16):10920-10937
Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.
Zhang Z, Ji C, Wang YN, Liu S, Wang M, Xu X, Zhang D
Cells 2022 Aug 17;11(16)
Cells 2022 Aug 17;11(16)
Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity.
Li Q, Zhong X, Yao W, Yu J, Wang C, Li Z, Lai S, Qu F, Fu X, Huang X, Zhang D, Liu Y, Li H
The Journal of biological chemistry 2022 Apr;298(4):101753
The Journal of biological chemistry 2022 Apr;298(4):101753
AKT serine/threonine kinase 2-mediated phosphorylation of fascin threonine 403 regulates esophageal cancer progression.
Zhang ZD, Wen B, Li DJ, Deng DX, Wu XD, Cheng YW, Liao LD, Long L, Dong G, Xu LY, Li EM
The international journal of biochemistry & cell biology 2022 Apr;145:106188
The international journal of biochemistry & cell biology 2022 Apr;145:106188
A functional PVA aerogel-based membrane obtaining sutureability through modified electrospinning technology and achieving promising anti-adhesion effect after cardiac surgery.
Jin D, Yang S, Wu S, Yin M, Kuang H
Bioactive materials 2022 Apr;10:355-366
Bioactive materials 2022 Apr;10:355-366
Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma.
Ganesa S, Sule A, Sundaram RK, Bindra RS
Scientific reports 2022 Apr 6;12(1):5827
Scientific reports 2022 Apr 6;12(1):5827
The Role of ATF3 in Neuronal Differentiation and Development of Neuronal Networks in Opossum Postnatal Cortical Cultures.
Petrović A, Ban J, Ivaničić M, Tomljanović I, Mladinic M
International journal of molecular sciences 2022 Apr 29;23(9)
International journal of molecular sciences 2022 Apr 29;23(9)
Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via TRIM21, leading to cell death and defective myogenesis.
Soliman HAN, Toso EA, Darwish IE, Ali SM, Kyba M
Cell death & disease 2022 Apr 25;13(4):405
Cell death & disease 2022 Apr 25;13(4):405
Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
Yang Y, Xiao Q, Yin J, Li C, Yu D, He Y, Yang Z, Wang G
Communications biology 2022 Apr 19;5(1):374
Communications biology 2022 Apr 19;5(1):374
Characteristics of the Gut Microbiome and IL-13/TGF-β1 Mediated Fibrosis in Post-Kasai Cholangitis of Biliary Atresia.
Meng L, Liu J, Wang J, Du M, Zhang S, Huang Y, Shen Z, Dong R, Chen G, Zheng S
Frontiers in pediatrics 2021;9:751204
Frontiers in pediatrics 2021;9:751204
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes.
Giordano I, Pirone L, Muratore V, Landaluze E, Pérez C, Lang V, Garde-Lapido E, Gonzalez-Lopez M, Barroso-Gomila O, Vertegaal ACO, Aransay AM, Rodriguez JA, Rodriguez MS, Sutherland JD, Barrio R
Frontiers in cell and developmental biology 2021;9:715868
Frontiers in cell and developmental biology 2021;9:715868
Development and Validation of a Ferroptosis-Related Gene Signature for Overall Survival Prediction in Lung Adenocarcinoma.
Tian Q, Zhou Y, Zhu L, Gao H, Yang J
Frontiers in cell and developmental biology 2021;9:684259
Frontiers in cell and developmental biology 2021;9:684259
WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells.
Li Y, Bhanja A, Upadhyaya A, Zhao X, Song W
Frontiers in cell and developmental biology 2021;9:646077
Frontiers in cell and developmental biology 2021;9:646077
Samm50 Promotes Hypertrophy by Regulating Pink1-Dependent Mitophagy Signaling in Neonatal Cardiomyocytes.
Xu R, Kang L, Wei S, Yang C, Fu Y, Ding Z, Zou Y
Frontiers in cardiovascular medicine 2021;8:748156
Frontiers in cardiovascular medicine 2021;8:748156
SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.
Jin Y, Zhang M, Li M, Zhang H, Zhao L, Qian C, Li S, Zhang H, Gao M, Pan B, Li R, Wan X, Cao C
Frontiers in molecular biosciences 2021;8:725319
Frontiers in molecular biosciences 2021;8:725319
Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules.
Messerschmidt VL, Chintapula U, Kuriakose AE, Laboy S, Truong TTD, Kydd LA, Jaworski J, Pan Z, Sadek H, Nguyen KT, Lee J
Frontiers in cardiovascular medicine 2021;8:707897
Frontiers in cardiovascular medicine 2021;8:707897
Indoleamine-2,3-Dioxygenase Activates Wnt/β-Catenin Inducing Kidney Fibrosis after Acute Kidney Injury.
Pan B, Zhang H, Hong Y, Ma M, Wan X, Cao C
Gerontology 2021;67(5):611-619
Gerontology 2021;67(5):611-619
JNK Signaling Pathway Mediates Fluoride-Induced Upregulation of CK1α during Enamel Formation.
Yang Z, Shi G, Guo J, Zhou Y, Jia J
Caries research 2021;55(3):225-233
Caries research 2021;55(3):225-233
Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway.
You Z, He L, Yan N
Journal of healthcare engineering 2021;2021:6394514
Journal of healthcare engineering 2021;2021:6394514
miR-708 Negatively Regulates TNFα/IL-1β Signaling by Suppressing NF-κB and Arachidonic Acid Pathways.
Monteleone NJ, Lutz CS
Mediators of inflammation 2021;2021:5595520
Mediators of inflammation 2021;2021:5595520
Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells.
Ji R, Ma L, Chen X, Sun R, Zhang L, Saiyin H, Wei W
PloS one 2021;16(11):e0258204
PloS one 2021;16(11):e0258204
Valproic Acid Induces Autism-Like Synaptic and Behavioral Deficits by Disrupting Histone Acetylation of Prefrontal Cortex ALDH1A1 in Rats.
Liu H, Tan M, Cheng B, Wang S, Xiao L, Zhu J, Wu Q, Lai X, Zhang Q, Chen J, Li T
Frontiers in neuroscience 2021;15:641284
Frontiers in neuroscience 2021;15:641284
Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release.
Chen H, Dai Y, Cui J, Yin X, Feng W, Lv M, Song H
Drug design, development and therapy 2021;15:1691-1704
Drug design, development and therapy 2021;15:1691-1704
Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease.
Tian Y, He M, Pan L, Yuan X, Xiong M, Meng L, Yao Z, Yu Z, Ye K, Zhang Z
Frontiers in aging neuroscience 2021;13:760781
Frontiers in aging neuroscience 2021;13:760781
Bifidobacterium infantis Maintains Genome Stability in Ulcerative Colitis via Regulating Anaphase-Promoting Complex Subunit 7.
Han T, Hu X, Li K, Zhang D, Zhang Y, Li J
Frontiers in microbiology 2021;12:761113
Frontiers in microbiology 2021;12:761113
TAZ maintains telomere length in TNBC cells by mediating Rad51C expression.
Yang L, Wang B, Jiao X, Zhou C, Chen S, Gao X, Sun W, Song S, Li J, Liu J, Wang Y, Liu P
Breast cancer research : BCR 2021 Sep 6;23(1):89
Breast cancer research : BCR 2021 Sep 6;23(1):89
PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.
Cheng YW, Zhang ZB, Lan BD, Lin JR, Chen XH, Kong LR, Xu L, Ruan CC, Gao PJ
The Journal of experimental medicine 2021 Sep 6;218(9)
The Journal of experimental medicine 2021 Sep 6;218(9)
Discovery of Potent Antiallergic Agents Based on an o-Aminopyridinyl Alkynyl Scaffold.
Xie Z, Xiang C, Li X, Fan C, Chen T, Liu M, Ma Y, Bai F, Tang W, Hu Y
Journal of medicinal chemistry 2021 Sep 23;64(18):13588-13603
Journal of medicinal chemistry 2021 Sep 23;64(18):13588-13603
HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1.
Zhang Q, Kang Y, Wang S, Gonzalez GM, Li W, Hui H, Wang Y, Rana TM
Nature communications 2021 Sep 20;12(1):5543
Nature communications 2021 Sep 20;12(1):5543
A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
Yu S, Lu Y, Su A, Chen J, Li J, Zhou B, Liu X, Xia Q, Li Y, Li J, Huang M, Ye Y, Zhao Q, Jiang S, Yan X, Wang X, Di C, Pan J, Su S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Oct;8(19):e2101848
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Oct;8(19):e2101848
IKKε knockout alleviates angiotensin II-induced apoptosis and excessive autophagy in vascular smooth muscle cells by regulating the ERK1/2 pathway.
Chen G, Xu Y, Yao Y, Cao Y, Liu Y, Chai H, Chen W, Chen X
Experimental and therapeutic medicine 2021 Oct;22(4):1051
Experimental and therapeutic medicine 2021 Oct;22(4):1051
Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets.
Wang D, Pan D, Xie B, Wang S, Xing X, Liu X, Ma Y, Andersson L, Wu J, Jiang L
PLoS genetics 2021 Oct;17(10):e1009862
PLoS genetics 2021 Oct;17(10):e1009862
Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.
Kwok HH, Gao B, Chan KH, Ip MS, Minna JD, Lam DC
Cancers 2021 Oct 25;13(21)
Cancers 2021 Oct 25;13(21)
Disrupting RhoA activity by blocking Arhgef3 expression mitigates microglia-induced neuroinflammation post spinal cord contusion.
Liao L, Qian ZY, Li XY, Yang DS, Lei BJ, Li HJ, Hong X
Journal of neuroimmunology 2021 Oct 15;359:577688
Journal of neuroimmunology 2021 Oct 15;359:577688
Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss.
Jian B, Pang J, Xiong H, Zhang W, Zhan T, Su Z, Lin H, Zhang H, He W, Zheng Y
Toxicology letters 2021 Oct 10;350:249-260
Toxicology letters 2021 Oct 10;350:249-260
Effect of Metformin and Simvastatin in Inhibiting Proadipogenic Transcription Factors.
Jakab J, Zjalić M, Mikšić Š, Tušek I, Ćosić V, Volarić N, Nakić D, Včev A, Miškić B
Current issues in molecular biology 2021 Nov 25;43(3):2082-2097
Current issues in molecular biology 2021 Nov 25;43(3):2082-2097
Effects of aging on the histology and biochemistry of rat tendon healing.
Lai F, Tang H, Wang J, Lu K, Bian X, Wang Y, Shi Y, Guo Y, He G, Zhou M, Zhang X, Zhou B, Zhang J, Chen W, Tang K
BMC musculoskeletal disorders 2021 Nov 15;22(1):949
BMC musculoskeletal disorders 2021 Nov 15;22(1):949
11βHSD2 Efficacy in Preventing Transcriptional Activation of the Mineralocorticoid Receptor by Corticosterone.
Ali Y, Kuppusamy M, Velarde-Miranda C, Gomez-Sanchez CM, Plonczynski M, Gomez-Sanchez CE, Gomez-Sanchez EP
Journal of the Endocrine Society 2021 Nov 1;5(11):bvab146
Journal of the Endocrine Society 2021 Nov 1;5(11):bvab146
HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production.
Wang J, Chen Y, Zeng Z, Feng R, Wang Q, Zhang Q, Sun K, Chen AF, Lu Y, Yu Y
Experimental cell research 2021 Nov 1;408(1):112831
Experimental cell research 2021 Nov 1;408(1):112831
Fzd7/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer.
Zhang Z, Xu Y, Zhao C
Cancer medicine 2021 May;10(10):3332-3345
Cancer medicine 2021 May;10(10):3332-3345
Silencing TAK1 reduces MAPKs-MMP2/9 expression to reduce inflammation-driven neurohistological disruption post spinal cord injury.
Jiang S, Wu Y, Wu S, Ye S, Kong R, Chang J, Xia M, Bao J, Peng X, Hong X, Qian Z, Li H
Cell death discovery 2021 May 8;7(1):96
Cell death discovery 2021 May 8;7(1):96
Highly Conserved C-Terminal Region of Indian Hedgehog N-Fragment Contributes to Its Auto-Processing and Multimer Formation.
Wang X, Liu H, Liu Y, Han G, Wang Y, Chen H, He L, Ma G
Biomolecules 2021 May 25;11(6)
Biomolecules 2021 May 25;11(6)
Analyses of key mRNAs and lncRNAs for different osteo-differentiation potentials of periodontal ligament stem cell and gingival mesenchymal stem cell.
Jia L, Zhang Y, Li D, Zhang W, Zhang D, Xu X
Journal of cellular and molecular medicine 2021 May 24;25(13):6217-31
Journal of cellular and molecular medicine 2021 May 24;25(13):6217-31
EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function.
Bahl S, Ling H, Acharige NPN, Santos-Barriopedro I, Pflum MKH, Seto E
Cell death & disease 2021 May 11;12(5):469
Cell death & disease 2021 May 11;12(5):469
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
Qin W, Tong X, Liang R, Tang K, Wu X, Jia Y, Tan N
Journal of ethnopharmacology 2021 May 10;271:113827
Journal of ethnopharmacology 2021 May 10;271:113827
TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.
Ma M, Shi F, Zhai R, Wang H, Li K, Xu C, Yao W, Zhou F
Molecular biology reports 2021 Mar;48(3):2365-2375
Molecular biology reports 2021 Mar;48(3):2365-2375
Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation.
Heck AL, Mishra S, Prenzel T, Feulner L, Achhammer E, Särchen V, Blagg BSJ, Schneider-Brachert W, Schütze S, Fritsch J
Immunobiology 2021 Mar;226(2):152070
Immunobiology 2021 Mar;226(2):152070
Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis.
Li Y, Zeng X, Lu D, Yin M, Shan M, Gao Y
Human reproduction (Oxford, England) 2021 Mar 18;36(4):951-964
Human reproduction (Oxford, England) 2021 Mar 18;36(4):951-964
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA
Acta neuropathologica communications 2021 Mar 12;9(1):41
Acta neuropathologica communications 2021 Mar 12;9(1):41
Mitochondrial activity regulates the differentiation of skin-derived mesenchymal stem cells into brown adipocytes to contribute to hypertension.
Xi W, Chen W, Sun W, Li X, Suo Z, Jiang G, Gao P, Li Q
Stem cell research & therapy 2021 Mar 10;12(1):167
Stem cell research & therapy 2021 Mar 10;12(1):167
Development and Validation of High-Content Analysis for Screening HDAC6-Selective Inhibitors.
Nong Y, Hou Y, Pu Y, Li S, Lan Y
SLAS discovery : advancing life sciences R & D 2021 Jun;26(5):628-641
SLAS discovery : advancing life sciences R & D 2021 Jun;26(5):628-641
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.
Yi JS, Sias-Garcia O, Nasholm N, Hu X, Iniguez AB, Hall MD, Davis M, Guha R, Moreno-Smith M, Barbieri E, Duong K, Koach J, Qi J, Bradner JE, Stegmaier K, Weiss WA, Gustafson WC
Neoplasia (New York, N.Y.) 2021 Jun;23(6):624-633
Neoplasia (New York, N.Y.) 2021 Jun;23(6):624-633
A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer.
Liu X, Hu Q, Wang W, Ma H, Pu J, Cui J, Gong T, Wu Y, Lu W, Huang J
Biochemical pharmacology 2021 Jun;188:114583
Biochemical pharmacology 2021 Jun;188:114583
An Ultra-Stable, Oxygen-Supply Nanoprobe Emitting in Near-Infrared-II Window to Guide and Enhance Radiotherapy by Promoting Anti-Tumor Immunity.
Wang M, Li H, Huang B, Chen S, Cui R, Sun ZJ, Zhang M, Sun T
Advanced healthcare materials 2021 Jun;10(12):e2100090
Advanced healthcare materials 2021 Jun;10(12):e2100090
WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression.
Wu M, Xia X, Hu J, Fowlkes NW, Li S
Nature communications 2021 Jun 9;12(1):3500
Nature communications 2021 Jun 9;12(1):3500
Downregulation of Prolactin-Induced Protein Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells.
Li X, Zhang Y, Jia L, Xing Y, Zhao B, Sui L, Liu D, Xu X
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 7;27:e930610
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 7;27:e930610
A single amino acid substitution in PRKDC is a determinant of sensitivity to Adriamycin-induced renal injury in mouse.
Watanabe M, Takahashi Y, Hiura K, Nakano K, Okamura T, Sasaki H, Sasaki N
Biochemical and biophysical research communications 2021 Jun 4;556:121-126
Biochemical and biophysical research communications 2021 Jun 4;556:121-126
Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure.
Milewski K, Czarnecka AM, Albrecht J, Zielińska M
International journal of molecular sciences 2021 Jun 22;22(13)
International journal of molecular sciences 2021 Jun 22;22(13)
Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.
Li F, Li J, Yu J, Pan T, Yu B, Sang Q, Dai W, Hou J, Yan C, Zang M, Zhu Z, Su L, Li YY, Liu B
EBioMedicine 2021 Jul;69:103436
EBioMedicine 2021 Jul;69:103436
DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells.
Qi Z, Zhang Y, Yao K, Zhang M, Xu Y, Zhang J, Bai X, Zu H
Neurochemical research 2021 Jul;46(7):1627-1640
Neurochemical research 2021 Jul;46(7):1627-1640
The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer.
Wang JZ, Zhu W, Han J, Yang X, Zhou R, Lu HC, Yu H, Yuan WB, Li PC, Tao J, Lu Q, Wei JF, Yang H
Cancer communications (London, England) 2021 Jul;41(7):560-575
Cancer communications (London, England) 2021 Jul;41(7):560-575
Perturbation of astroglial Slc38 glutamine transporters by NH(4)(+) contributes to neurophysiologic manifestations in acute liver failure.
Hamdani EH, Popek M, Frontczak-Baniewicz M, Utheim TP, Albrecht J, Zielińska M, Chaudhry FA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jul;35(7):e21588
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jul;35(7):e21588
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.
Huang D, Chen X, Zeng X, Lao L, Li J, Xing Y, Lu Y, Ouyang Q, Chen J, Yang L, Su F, Yao H, Liu Q, Su S, Song E
Nature immunology 2021 Jul;22(7):865-879
Nature immunology 2021 Jul;22(7):865-879
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.
Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, Adachi K, Xia G, Yun K, Sarkar P, Ashizawa T
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):1710-1728
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021 Jul;18(3):1710-1728
Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways.
Hu Y, Jing J, Shi Y, Zhang P, Dong D, Wu Y, Dong X, Li E, Fan Y
Translational cancer research 2021 Jul;10(7):3306-3316
Translational cancer research 2021 Jul;10(7):3306-3316
Rice Husk Silica Liquid Protects Pancreatic β Cells from Streptozotocin-Induced Oxidative Damage.
Chen HY, Chiang YF, Wang KL, Huang TC, Ali M, Shieh TM, Chang HY, Hong YH, Hsia SM
Antioxidants (Basel, Switzerland) 2021 Jul 5;10(7)
Antioxidants (Basel, Switzerland) 2021 Jul 5;10(7)
Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE).
Chen HY, Cheng WP, Chiang YF, Hong YH, Ali M, Huang TC, Wang KL, Shieh TM, Chang HY, Hsia SM
International journal of molecular sciences 2021 Jul 31;22(15)
International journal of molecular sciences 2021 Jul 31;22(15)
Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human.
Chijimatsu R, Miwa S, Okamura G, Miyahara J, Tachibana N, Ishikura H, Higuchi J, Maenohara Y, Tsuji S, Sameshima S, Takagi K, Nakazato K, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Tanaka S, Saito T
Stem cell research & therapy 2021 Jul 15;12(1):405
Stem cell research & therapy 2021 Jul 15;12(1):405
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.
Chen H, Qian Z, Zhang S, Tang J, Fang L, Jiang F, Ge D, Chang J, Cao J, Yang L, Cao X
Redox biology 2021 Jan;38:101774
Redox biology 2021 Jan;38:101774
Citrate regulates extracellular matrix mineralization during osteoblast differentiation in vitro.
Wu X, Dai H, Yu S, Zhao Y, Long Y, Li W, Tu J
Journal of inorganic biochemistry 2021 Jan;214:111269
Journal of inorganic biochemistry 2021 Jan;214:111269
Defining the protein and lipid constituents of tubular recycling endosomes.
Farmer T, Xie S, Naslavsky N, Stöckli J, James DE, Caplan S
The Journal of biological chemistry 2021 Jan-Jun;296:100190
The Journal of biological chemistry 2021 Jan-Jun;296:100190
GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
Xia Z, Zhang X, Liu P, Zhang R, Huang Z, Li D, Xiao X, Wu M, Ning N, Zhang Q, Zhang J, Liu M, Jiao B, Ren R
Cell death & disease 2021 Jan 9;12(1):54
Cell death & disease 2021 Jan 9;12(1):54
Lipolytic gene DAGLA is targeted by miR-223 in chicken hepatocytes.
Wang X, Li Y, Qu L, Guo J, Dou T, Hu Y, Ma M, Wang K
Gene 2021 Jan 30;767:145184
Gene 2021 Jan 30;767:145184
Maternal vitamin A deficiency impairs cholinergic and nitrergic neurons, leading to gastrointestinal dysfunction in rat offspring via RARβ.
Tan M, Yang T, Liu H, Xiao L, Li C, Zhu J, Chen J, Li T
Life sciences 2021 Jan 1;264:118688
Life sciences 2021 Jan 1;264:118688
Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model.
Smeltzer S, Quadri Z, Miller A, Zamudio F, Hunter J, Stewart NJF, Saji S, Lee DC, Chaput D, Selenica MB
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165939
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165939
Pyrvinium pamoate inhibits cell proliferation through ROS-mediated AKT-dependent signaling pathway in colorectal cancer.
Zheng W, Hu J, Lv Y, Bai B, Shan L, Chen K, Dai S, Zhu H
Medical oncology (Northwood, London, England) 2021 Feb 8;38(2):21
Medical oncology (Northwood, London, England) 2021 Feb 8;38(2):21
Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.
Davis RR, Li B, Yun SY, Chan A, Nareddy P, Gunawan S, Ayaz M, Lawrence HR, Reuther GW, Lawrence NJ, Schönbrunn E
Journal of medicinal chemistry 2021 Feb 25;64(4):2228-2241
Journal of medicinal chemistry 2021 Feb 25;64(4):2228-2241
Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors.
Zhang Y, Wang S, Wu Y, Hou W, Yuan L, Shen C, Wang J, Ye J, Zheng Q, Ma J, Xu J, Wei M, Li Z, Nian S, Xiong H, Zhang L, Shi Y, Fu B, Cao J, Yang C, Li Z, Yang T, Liu L, Yu H, Hu J, Ge S, Chen Y, Zhang T, Zhang J, Cheng T, Yuan Q, Xia N
Small methods 2021 Feb 15;5(2):2001031
Small methods 2021 Feb 15;5(2):2001031
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Pawlik MJ, Obara-Michlewska M, Popek MP, Czarnecka AM, Czuczwar SJ, Łuszczki J, Kołodziej M, Acewicz A, Wierzba-Bobrowicz T, Albrecht J
Brain research 2021 Feb 15;1753:147253
Brain research 2021 Feb 15;1753:147253
Halofuginone triggers a transcriptional program centered on ribosome biogenesis and function in honey bees.
Flores ME, McNamara-Bordewick NK, Lovinger NL, Snow JW
Insect biochemistry and molecular biology 2021 Dec;139:103667
Insect biochemistry and molecular biology 2021 Dec;139:103667
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600
Bioengineered 2021 Dec;12(1):589-600
Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.
Li H, Wang M, Huang B, Zhu SW, Zhou JJ, Chen DR, Cui R, Zhang M, Sun ZJ
Nature communications 2021 Dec 9;12(1):7149
Nature communications 2021 Dec 9;12(1):7149
TTP protects against acute liver failure by regulating CCL2 and CCL5 through m6A RNA methylation.
Xiao P, Li M, Zhou M, Zhao X, Wang C, Qiu J, Fang Q, Jiang H, Dong H, Zhou R
JCI insight 2021 Dec 8;6(23)
JCI insight 2021 Dec 8;6(23)
Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
Wu Y, Qi Y, Qiu Z, Chen W
Biochemical and biophysical research communications 2021 Dec 3;581:81-88
Biochemical and biophysical research communications 2021 Dec 3;581:81-88
The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells.
Shamloul A, Steinemann G, Roos K, Liem CH, Bernd J, Braun T, Zakrzewicz A, Berkholz J
Cells 2021 Dec 13;10(12)
Cells 2021 Dec 13;10(12)
Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.
Jaumotte JD, Franks AL, Bargerstock EM, Kisanga EP, Menden HL, Ghersi A, Omar M, Wang L, Rudine A, Short KL, Silswal N, Cole TJ, Sampath V, Monaghan-Nichols AP, DeFranco DB
Neurobiology of disease 2021 Aug;156:105422
Neurobiology of disease 2021 Aug;156:105422
Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma.
Ma X, Yang S, Jiang H, Wang Y, Xiang Z
Journal of translational medicine 2021 Aug 26;19(1):368
Journal of translational medicine 2021 Aug 26;19(1):368
2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.
Zhao Y, He L, Wang T, Zhu L, Yan N
Metabolites 2021 Aug 23;11(8)
Metabolites 2021 Aug 23;11(8)
HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity.
Chai Q, Li S, Collins MK, Li R, Ahmad I, Johnson SF, Frabutt DA, Yang Z, Shen X, Sun L, Hu J, Hultquist JF, Peterlin BM, Zheng YH
Cell reports 2021 Aug 10;36(6):109514
Cell reports 2021 Aug 10;36(6):109514
The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer.
Liu J, Lao L, Chen J, Li J, Zeng W, Zhu X, Li J, Chen X, Yang L, Xing Y, Chen F, Huang D, Zhang X, Wei W, Gong C, Huang S, Yu Z, Li Z, Yang L, Liu J, Liu X, Zheng Q, Meng X, Liang J, Sun L, Zeng M, Li M, Liu Q, Su S, Song E
Nature cancer 2021 Apr;2(4):457-473
Nature cancer 2021 Apr;2(4):457-473
Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors.
Crean-Tate KK, Braley C, Dey G, Esakov E, Saygin C, Trestan A, Silver DJ, Turaga SM, Connor EV, DeBernardo R, Michener CM, Rose PG, Lathia J, Reizes O
Journal of ovarian research 2021 Apr 22;14(1):55
Journal of ovarian research 2021 Apr 22;14(1):55
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer.
Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF
Nature communications 2021 Apr 15;12(1):2259
Nature communications 2021 Apr 15;12(1):2259
The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma.
Lipchick BC, Utley A, Han Z, Moparthy S, Yun DH, Bianchi-Smiraglia A, Wolff DW, Fink E, Liu L, Furdui CM, Lee J, Lee KP, Nikiforov MA
Blood advances 2021 Apr 13;5(7):1933-1946
Blood advances 2021 Apr 13;5(7):1933-1946
miR-3 Encoded by Hepatitis B Virus Downregulates PTEN Protein Expression and Promotes Cell Proliferation.
Tang J, Xiao X, Jiang Y, Tian Y, Peng Z, Yang M, Xu Z, Gong G
Journal of hepatocellular carcinoma 2020;7:257-269
Journal of hepatocellular carcinoma 2020;7:257-269
Electric field down-regulates CD9 to promote keratinocytes migration through AMPK pathway.
Ji R, Teng M, Zhang Z, Wang W, Zhang Q, Lv Y, Zhang J, Jiang X
International journal of medical sciences 2020;17(7):865-873
International journal of medical sciences 2020;17(7):865-873
LRG1 promotes corneal angiogenesis and lymphangiogenesis in a corneal alkali burn mouse model.
Song S, Cheng J, Yu BJ, Zhou L, Xu HF, Yang LL
International journal of ophthalmology 2020;13(3):365-373
International journal of ophthalmology 2020;13(3):365-373
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.
Fan Y, Ma K, Jing J, Wang C, Hu Y, Shi Y, Li E, Geng Q
Journal of Cancer 2020;11(1):25-40
Journal of Cancer 2020;11(1):25-40
Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model.
Gu T, Zhao S, Jin G, Song M, Zhi Y, Zhao R, Ma F, Zheng Y, Wang K, Liu H, Xin M, Han W, Li X, Dong CD, Liu K, Dong Z
Frontiers in immunology 2020;11:621441
Frontiers in immunology 2020;11:621441
Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis.
Xie Z, Lu H, Yang S, Zeng Y, Li W, Wang L, Luo G, Fang F, Zeng T, Cheng W
Frontiers in pharmacology 2020;11:568423
Frontiers in pharmacology 2020;11:568423
Total Glycosides of Cistanche deserticola Promote Neurological Function Recovery by Inducing Neurovascular Regeneration via Nrf-2/Keap-1 Pathway in MCAO/R Rats.
Wang F, Li R, Tu P, Chen J, Zeng K, Jiang Y
Frontiers in pharmacology 2020;11:236
Frontiers in pharmacology 2020;11:236
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/β-Catenin Signaling Pathway.
Liu D, Song Z, Wang X, Ouyang L
Frontiers in oncology 2020;10:865
Frontiers in oncology 2020;10:865
Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria.
Ren YZ, Zhang BZ, Zhao XJ, Zhang ZY
Journal of neurochemistry 2020 Sep;154(5):530-546
Journal of neurochemistry 2020 Sep;154(5):530-546
Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy via Suppression of Atrogin-1.
Miyawaki A, Rojasawasthien T, Hitomi S, Aoki Y, Urata M, Inoue A, Matsubara T, Morikawa K, Habu M, Tominaga K, Kokabu S
In vivo (Athens, Greece) 2020 Sep-Oct;34(5):2345-2351
In vivo (Athens, Greece) 2020 Sep-Oct;34(5):2345-2351
FAM122A Inhibits Erythroid Differentiation through GATA1.
Chen J, Zhou Q, Liu MH, Yang YS, Wang YQ, Huang Y, Chen GQ
Stem cell reports 2020 Sep 8;15(3):721-734
Stem cell reports 2020 Sep 8;15(3):721-734
Non-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1.
Yin P, Bai Y, Wang Z, Sun Y, Gao J, Na L, Zhang Z, Wang W, Zhao C
Cell communication and signaling : CCS 2020 Sep 7;18(1):143
Cell communication and signaling : CCS 2020 Sep 7;18(1):143
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Chen DB, Xie XW, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Fei R, Qin WY, Wang JH, Wu X, Shao QX, Wei L, Chen HS
Scientific reports 2020 Sep 3;10(1):14538
Scientific reports 2020 Sep 3;10(1):14538
CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.
Li H, Che J, Jiang M, Cui M, Feng G, Dong J, Zhang S, Lu L, Liu W, Fan S
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
Cell communication and signaling : CCS 2020 Sep 17;18(1):152
High salt diet may promote progression of breast tumor through eliciting immune response.
Chen J, Liu X, Huang H, Zhang F, Lu Y, Hu H
International immunopharmacology 2020 Oct;87:106816
International immunopharmacology 2020 Oct;87:106816
Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.
Hamamoto Y, Ouhara K, Munenaga S, Shoji M, Ozawa T, Hisatsune J, Kado I, Kajiya M, Matsuda S, Kawai T, Mizuno N, Fujita T, Hirata S, Tanimoto K, Nakayama K, Kishi H, Sugiyama E, Kurihara H
Arthritis research & therapy 2020 Oct 19;22(1):249
Arthritis research & therapy 2020 Oct 19;22(1):249
Physiology and Morphological Correlates of Excitatory Transmission are Preserved in Glutamine Transporter SN1-Depleted Mouse Frontal Cortex.
Popek M, Bobula B, Sowa J, Hess G, Frontczak-Baniewicz M, Albrecht J, Zielińska M
Neuroscience 2020 Oct 15;446:124-136
Neuroscience 2020 Oct 15;446:124-136
m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana TM
The EMBO journal 2020 Oct 15;39(20):e104514
The EMBO journal 2020 Oct 15;39(20):e104514
AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.
Zhao W, Shi CS, Harrison K, Hwang IY, Nabar NR, Wang M, Kehrl JH
Journal of immunology (Baltimore, Md. : 1950) 2020 Oct 15;205(8):2255-2264
Journal of immunology (Baltimore, Md. : 1950) 2020 Oct 15;205(8):2255-2264
Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy.
Shirakawa T, Miyawaki A, Matsubara T, Okumura N, Okamoto H, Nakai N, Rojasawasthien T, Morikawa K, Inoue A, Goto A, Washio A, Tsujisawa T, Kawamoto T, Kokabu S
Nutrients 2020 Oct 11;12(10)
Nutrients 2020 Oct 11;12(10)
Endoplasmic Reticulum Stress Affects Cholesterol Homeostasis by Inhibiting LXRα Expression in Hepatocytes and Macrophages.
Wang T, Zhao Y, You Z, Li X, Xiong M, Li H, Yan N
Nutrients 2020 Oct 11;12(10)
Nutrients 2020 Oct 11;12(10)
The beneficial effect of oyster peptides and oyster powder on cyclophosphamide-induced reproductive impairment in male rats: A comparative study.
Li M, Zhou M, Wei Y, Jia F, Yan Y, Zhang R, Cai M, Gu R
Journal of food biochemistry 2020 Nov;44(11):e13468
Journal of food biochemistry 2020 Nov;44(11):e13468
Suppressor of Ty 16 promotes lung cancer malignancy and is negatively regulated by miR-1227-5p.
Yang L, Wang X, Jiao X, Tian B, Zhang M, Zhou C, Wang R, Chen H, Wang B, Li J, Liu J, Zhang G, Liu P
Cancer science 2020 Nov;111(11):4075-4087
Cancer science 2020 Nov;111(11):4075-4087
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum MA, Mack SC, Chavez L, Perry A, Raleigh DR, Rich JN
Cancer discovery 2020 Nov;10(11):1722-1741
Cancer discovery 2020 Nov;10(11):1722-1741
Magnesium Calcium Phosphate Cement Incorporating Citrate for Vascularized Bone Regeneration.
Wu X, Dai H, Yu S, Zhao Y, Long Y, Li W, Tu J
ACS biomaterials science & engineering 2020 Nov 9;6(11):6299-6308
ACS biomaterials science & engineering 2020 Nov 9;6(11):6299-6308
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.
Li L, Zhu S, Shu W, Guo Y, Guan Y, Zeng J, Wang H, Han L, Zhang J, Liu X, Li C, Hou X, Gao M, Ge J, Ren C, Zhang H, Schedl T, Guo X, Chen M, Wang Q
Molecular cell 2020 Nov 5;80(3):525-540.e9
Molecular cell 2020 Nov 5;80(3):525-540.e9
LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer.
Shi Q, Li Y, Li S, Jin L, Lai H, Wu Y, Cai Z, Zhu M, Li Q, Li Y, Wang J, Liu Y, Wu Z, Song E, Liu Q
Nature communications 2020 Nov 2;11(1):5513
Nature communications 2020 Nov 2;11(1):5513
Knockout of mouse receptor accessory protein 6 leads to sperm function and morphology defects†.
Devlin DJ, Agrawal Zaneveld S, Nozawa K, Han X, Moye AR, Liang Q, Harnish JM, Matzuk MM, Chen R
Biology of reproduction 2020 May 26;102(6):1234-1247
Biology of reproduction 2020 May 26;102(6):1234-1247
Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA.
Dai H, Chen R, Gui C, Tao T, Ge Y, Zhao X, Qin R, Yao W, Gu S, Jiang Y, Gui J
Stem cell research & therapy 2020 May 25;11(1):199
Stem cell research & therapy 2020 May 25;11(1):199
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.
Wu X, Spence JS, Das T, Yuan X, Chen C, Zhang Y, Li Y, Sun Y, Chandran K, Hang HC, Peng T
Cell chemical biology 2020 May 21;27(5):571-585.e6
Cell chemical biology 2020 May 21;27(5):571-585.e6
Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles.
Taha EA, Sogawa C, Okusha Y, Kawai H, Oo MW, Elseoudi A, Lu Y, Nagatsuka H, Kubota S, Satoh A, Okamoto K, Eguchi T
Cancers 2020 May 16;12(5)
Cancers 2020 May 16;12(5)
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
Davenne T, Klintman J, Sharma S, Rigby RE, Blest HTW, Cursi C, Bridgeman A, Dadonaite B, De Keersmaecker K, Hillmen P, Chabes A, Schuh A, Rehwinkel J
Cell reports 2020 May 12;31(6):107640
Cell reports 2020 May 12;31(6):107640
Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage.
Izem L, Liu Y, Morton RE
Journal of lipid research 2020 Mar;61(3):422-431
Journal of lipid research 2020 Mar;61(3):422-431
HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism.
Lu L, Li H, Wu X, Rao J, Zhou J, Fan S, Shen Q
Cell proliferation 2020 Mar;53(3):e12777
Cell proliferation 2020 Mar;53(3):e12777
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Zhang ZH, He JQ, Zhao YY, Chen HC, Tan NH
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.
Dhawan K, Naslavsky N, Caplan S
The Journal of biological chemistry 2020 Mar 20;295(12):3837-3850
The Journal of biological chemistry 2020 Mar 20;295(12):3837-3850
Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade.
Lin X, Dinglin X, Cao S, Zheng S, Wu C, Chen W, Li Q, Hu Q, Zheng F, Wu Z, Lin DC, Yao Y, Xu X, Xie Z, Liu Q, Yao H, Hu H
Cell reports 2020 Jun 9;31(10):107753
Cell reports 2020 Jun 9;31(10):107753
miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.
Monteleone NJ, Lutz CS
Oncotarget 2020 Jun 30;11(26):2464-2483
Oncotarget 2020 Jun 30;11(26):2464-2483
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E
Nature 2020 Jul;583(7814):133-138
Nature 2020 Jul;583(7814):133-138
Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway.
Xiong Y, Zhao B, Zhang W, Jia L, Zhang Y, Xu X
Iranian journal of basic medical sciences 2020 Jul;23(7):954-960
Iranian journal of basic medical sciences 2020 Jul;23(7):954-960
HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV.
Hock DH, Reljic B, Ang CS, Muellner-Wong L, Mountford HS, Compton AG, Ryan MT, Thorburn DR, Stroud DA
Molecular & cellular proteomics : MCP 2020 Jul;19(7):1145-1160
Molecular & cellular proteomics : MCP 2020 Jul;19(7):1145-1160
Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Wu Y, Zhao Y, He X, He Z, Wang T, Wan L, Chen L, Yan N
Molecular medicine reports 2020 Jan;21(1):249-257
Molecular medicine reports 2020 Jan;21(1):249-257
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer.
Wang Z, Xiang Z, Zhu T, Chen J, Zhong MZ, Huang J, Wang KS, Li L, Sun LQ, Zhou WB
Oncology letters 2020 Jan;19(1):167-176
Oncology letters 2020 Jan;19(1):167-176
Calcium Channel α2δ1 Subunit Mediates Secondary Orofacial Hyperalgesia Through PKC-TRPA1/Gap Junction Signaling.
Cui WQ, Chu YX, Xu F, Chen T, Gao L, Feng Y, Hu XM, Yang W, Du LX, Zhang WW, Mao-Ying QL, Mi WL, Wang YQ
The journal of pain 2020 Jan-Feb;21(1-2):238-257
The journal of pain 2020 Jan-Feb;21(1-2):238-257
Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.
Jia L, Xiong Y, Zhang W, Ma X, Xu X
Experimental cell research 2020 Jan 15;386(2):111717
Experimental cell research 2020 Jan 15;386(2):111717
Glibenclamide ameliorates transplant-induced arteriosclerosis and inhibits macrophage migration and MCP-1 expression.
Zou Y, Zhou C, Xu H, Yu J, Ye P, Zhang H, Chen S, Zhao J, Le S, Cui J, Jiang L, Wu J, Xia J
Life sciences 2020 Jan 15;241:117141
Life sciences 2020 Jan 15;241:117141
The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.
Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, Chang X, Jin Z, Li J, Zhu Z, Liu B, Su L
Oncogene 2020 Feb;39(7):1414-1428
Oncogene 2020 Feb;39(7):1414-1428
Adenosine A(2A) receptor activation prevents DOCA-salt induced hypertensive cardiac remodeling via iBAT.
Zhou YP, Ruan CC, Kong LR, Gao PJ
Biochemical and biophysical research communications 2020 Feb 19;
Biochemical and biophysical research communications 2020 Feb 19;
Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway.
He Y, Fang X, Shi J, Li X, Xie M, Liu X
Chemico-biological interactions 2020 Feb 1;317:108942
Chemico-biological interactions 2020 Feb 1;317:108942
Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes.
Skowrońska K, Kozłowska H, Albrecht J
Cell calcium 2020 Dec;92:102304
Cell calcium 2020 Dec;92:102304
Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.
Gao M, Lu W, Shu Y, Yang Z, Sun S, Xu J, Gan S, Zhu S, Qiu G, Zhuo F, Xu S, Wang Y, Chen J, Wu X, Huang J
CNS neuroscience & therapeutics 2020 Dec;26(12):1288-1302
CNS neuroscience & therapeutics 2020 Dec;26(12):1288-1302
Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation.
Yu T, Wan F, Liu C, Zhang X, Liu Z, Zhang J, Xiong J, Wang T, Zhang Z
European journal of pharmacology 2020 Dec 5;888:173586
European journal of pharmacology 2020 Dec 5;888:173586
Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell carcinoma metastasis by regulating Snail.
Yuan F, Miao Z, Chen W, Wu F, Wei C, Yong J, Xiao C
Journal of biochemistry 2020 Dec 26;168(6):651-657
Journal of biochemistry 2020 Dec 26;168(6):651-657
PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.
Huang Z, Liu M, Li D, Tan Y, Zhang R, Xia Z, Wang P, Jiao B, Liu P, Ren R
The Journal of biological chemistry 2020 Dec 25;295(52):18343-18354
The Journal of biological chemistry 2020 Dec 25;295(52):18343-18354
miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells.
Monteleone NJ, Lutz CS
Oncotarget 2020 Dec 22;11(51):4699-4721
Oncotarget 2020 Dec 22;11(51):4699-4721
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.
Jin CY, Du L, Nuerlan AH, Wang XL, Yang YW, Guo R
Aging 2020 Dec 19;13(3):3518-3535
Aging 2020 Dec 19;13(3):3518-3535
Protocol for Site-Specific Photo-Crosslinking Proteomics to Identify Protein-Protein Interactions in Mammalian Cells.
Chen C, Peng T
STAR protocols 2020 Dec 18;1(3):100109
STAR protocols 2020 Dec 18;1(3):100109
PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment.
Liu L, Fan L, Chan M, Kraakman MJ, Yang J, Fan Y, Aaron N, Wan Q, Carrillo-Sepulveda MA, Tall AR, Tabas I, Accili D, Qiang L
Diabetes 2020 Aug;69(8):1793-1803
Diabetes 2020 Aug;69(8):1793-1803
Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
Chen X, Bao G, Liu F
Cellular and molecular neurobiology 2020 Aug;40(6):999-1010
Cellular and molecular neurobiology 2020 Aug;40(6):999-1010
TNF‑α treatment increases DKK1 protein levels in primary osteoblasts via upregulation of DKK1 mRNA levels and downregulation of miR‑335‑5p.
Li S, Yin Y, Yao L, Lin Z, Sun S, Zhang J, Li X
Molecular medicine reports 2020 Aug;22(2):1017-1025
Molecular medicine reports 2020 Aug;22(2):1017-1025
Downregulation of GPR183 on infection restricts the early infection and intracellular replication of mycobacterium tuberculosis in macrophage.
Tang J, Shi Y, Zhan L, Qin C
Microbial pathogenesis 2020 Aug;145:104234
Microbial pathogenesis 2020 Aug;145:104234
Localization of ZIP14 and ZIP8 in HIBCPP Cells.
Morgan SE, Schroten H, Ishikawa H, Zhao N
Brain sciences 2020 Aug 8;10(8)
Brain sciences 2020 Aug 8;10(8)
Hydroxysafflor yellow A induces autophagy in human liver cancer cells by regulating Beclin 1 and ERK expression.
Chen Z, Liu L, Liu Y, Wang S, Zhang S, Dong R, Xu M, Ma Y, Wang J, Zhang Q, Wei P
Experimental and therapeutic medicine 2020 Apr;19(4):2989-2996
Experimental and therapeutic medicine 2020 Apr;19(4):2989-2996
STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease.
Wang X, Rao H, Zhao J, Wee A, Li X, Fei R, Huang R, Wu C, Liu F, Wei L
Laboratory investigation; a journal of technical methods and pathology 2020 Apr;100(4):542-552
Laboratory investigation; a journal of technical methods and pathology 2020 Apr;100(4):542-552
Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer.
Okusha Y, Eguchi T, Tran MT, Sogawa C, Yoshida K, Itagaki M, Taha EA, Ono K, Aoyama E, Okamura H, Kozaki KI, Calderwood SK, Takigawa M, Okamoto K
Cancers 2020 Apr 4;12(4)
Cancers 2020 Apr 4;12(4)
EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation.
Zhang Y, Yang C, Ge S, Wang L, Zhang J, Yang P
BMC molecular and cell biology 2020 Apr 16;21(1):29
BMC molecular and cell biology 2020 Apr 16;21(1):29
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
Tian F, Wang Z, He J, Zhang Z, Tan N
European journal of pharmacology 2020 Apr 15;873:172989
European journal of pharmacology 2020 Apr 15;873:172989
Intravaginal Administration of Human Type III Collagen-Derived Biomaterial with High Cell-Adhesion Activity to Treat Vaginal Atrophy in Rats.
You S, Liu S, Dong X, Li H, Zhu Y, Hu L
ACS biomaterials science & engineering 2020 Apr 13;6(4):1977-1988
ACS biomaterials science & engineering 2020 Apr 13;6(4):1977-1988
Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel.
Shi S, Montalbetti N, Wang X, Rush BM, Marciszyn AL, Baty CJ, Tan RJ, Carattino MD, Kleyman TR
The Journal of biological chemistry 2020 Apr 10;295(15):4950-4962
The Journal of biological chemistry 2020 Apr 10;295(15):4950-4962
X-linked inhibitor of apoptosis protein accelerates migration by inducing epithelial-mesenchymal transition through TGF-β signaling pathway in esophageal cancer cells.
Jin Y, Lu X, Wang M, Zhao X, Xue L
Cell & bioscience 2019;9:76
Cell & bioscience 2019;9:76
Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development.
Pruski M, Hu L, Yang C, Wang Y, Zhang JB, Zhang L, Huang Y, Rajnicek AM, St Clair D, McCaig CD, Lang B, Ding YQ
Frontiers in cell and developmental biology 2019;7:287
Frontiers in cell and developmental biology 2019;7:287
Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL.
Shi CS, Kehrl JH
Cell death discovery 2019;5:151
Cell death discovery 2019;5:151
SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes.
Shi CS, Nabar NR, Huang NN, Kehrl JH
Cell death discovery 2019;5:101
Cell death discovery 2019;5:101
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.
Fan Y, Li M, Ma K, Hu Y, Jing J, Shi Y, Li E, Dong D
Cancer biology & therapy 2019;20(5):617-632
Cancer biology & therapy 2019;20(5):617-632
Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.
Horikoshi N, Sharma D, Leonard F, Pandita RK, Charaka VK, Hambarde S, Horikoshi NT, Gaur Khaitan P, Chakraborty S, Cote J, Godin B, Hunt CR, Pandita TK
Communications biology 2019;2:253
Communications biology 2019;2:253
CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17.
Liu J, Zhu G, Jia N, Wang W, Wang Y, Yin M, Jiang X, Huang Y, Zhang J
International journal of biological sciences 2019;15(2):493-506
International journal of biological sciences 2019;15(2):493-506
Long Noncoding RNA GAS5 Acts As A Tumor Suppressor In Laryngeal Squamous Cell Carcinoma Via miR-21.
Lyu K, Xu Y, Yue H, Li Y, Zhao J, Chen L, Wu J, Zhu X, Chai L, Li C, Wen W, Lei W
Cancer management and research 2019;11:8487-8498
Cancer management and research 2019;11:8487-8498
Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis.
Li H, Lu T, Sun W, Ma R, Zhong H, Wei Y, Chen D, Wen Y, Carlsten C, Wen W
Frontiers in immunology 2019;10:2271
Frontiers in immunology 2019;10:2271
Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion.
Tong X, Liang R, Jia Y, Qin W, Guo C, Wu X, Wang Z, Chen D, Tan N
Frontiers in pharmacology 2019;10:1422
Frontiers in pharmacology 2019;10:1422
A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.
Bosnakovski D, da Silva MT, Sunny ST, Ener ET, Toso EA, Yuan C, Cui Z, Walters MA, Jadhav A, Kyba M
Science advances 2019 Sep;5(9):eaaw7781
Science advances 2019 Sep;5(9):eaaw7781
Nicotinic acetylcholine receptor subunit expression in the gastrocnemius and in the orbicularis oris before and after facial nerve injury in rats.
Xu J, Huang Y, Li S, Chen L, Xue Z
Neurological research 2019 Sep;41(9):817-826
Neurological research 2019 Sep;41(9):817-826
Different signalling in infarcted and non-infarcted areas of rat failing hearts: A role of necroptosis and inflammation.
Lichý M, Szobi A, Hrdlička J, Horváth C, Kormanová V, Rajtík T, Neckář J, Kolář F, Adameová A
Journal of cellular and molecular medicine 2019 Sep;23(9):6429-6441
Journal of cellular and molecular medicine 2019 Sep;23(9):6429-6441
Potential roles of lncRNA-Cox2 and EGR1 in regulating epidural fibrosis following laminectomy.
Qian ZY, Jiang F, Tang J, Ge DW, Chen HT, Zheng SN, Cao XJ, Ge YB, Yang L
European review for medical and pharmacological sciences 2019 Sep;23(17):7191-7199
European review for medical and pharmacological sciences 2019 Sep;23(17):7191-7199
Regulation of the Metal Transporters ZIP14 and ZnT10 by Manganese Intake in Mice.
Felber DM, Wu Y, Zhao N
Nutrients 2019 Sep 4;11(9)
Nutrients 2019 Sep 4;11(9)
miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.
Xu X, Chen X, Xu M, Liu X, Pan B, Qin J, Xu T, Zeng K, Pan Y, He B, Sun H, Sun L, Wang S
Aging 2019 Sep 22;11(18):7357-7385
Aging 2019 Sep 22;11(18):7357-7385
Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress.
He Z, Du X, Wu Y, Hua L, Wan L, Yan N
International journal of molecular medicine 2019 Oct;44(4):1289-1298
International journal of molecular medicine 2019 Oct;44(4):1289-1298
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Zimmerman KA, Song CJ, Li Z, Lever JM, Crossman DK, Rains A, Aloria EJ, Gonzalez NM, Bassler JR, Zhou J, Crowley MR, Revell DZ, Yan Z, Shan D, Benveniste EN, George JF, Mrug M, Yoder BK
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1841-1856
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1841-1856
Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.
Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, Wang Z, Tan N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109188
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109188
Increased miRNA-518b inhibits trophoblast migration and angiogenesis by targeting EGR1 in early embryonic arrest†.
Yang W, Lu Z, Zhi Z, Liu L, Deng L, Jiang X, Pang L
Biology of reproduction 2019 Oct 25;101(4):664-674
Biology of reproduction 2019 Oct 25;101(4):664-674
Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer.
Hu XM, Yang W, Du LX, Cui WQ, Mi WL, Mao-Ying QL, Chu YX, Wang YQ
Anesthesiology 2019 Nov;131(5):1125-1147
Anesthesiology 2019 Nov;131(5):1125-1147
Analyses of epithelial Na(+) channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating.
Wang X, Chen J, Shi S, Sheng S, Kleyman TR
The Journal of biological chemistry 2019 Nov 8;294(45):16765-16775
The Journal of biological chemistry 2019 Nov 8;294(45):16765-16775
Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.
Bellini A, Bessoltane-Bentahar N, Bhalshankar J, Clement N, Raynal V, Baulande S, Bernard V, Danzon A, Chicard M, Colmet-Daage L, Pierron G, Le Roux L, Planchon JM, Combaret V, Lapouble E, Corradini N, Thebaud E, Gambart M, Valteau-Couanet D, Michon J, Louis-Brennetot C, Janoueix-Lerosey I, Defachelles AS, Bourdeaut F, Delattre O, Schleiermacher G
International journal of cancer 2019 Nov 15;145(10):2781-2791
International journal of cancer 2019 Nov 15;145(10):2781-2791
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
Xie S, Farmer T, Naslavsky N, Caplan S
Journal of cell science 2019 Nov 14;132(22)
Journal of cell science 2019 Nov 14;132(22)
The mTOR-RUNX1 pathway regulates DC-SIGN expression in renal tubular epithelial cells.
Zhou S, Zhang L, Feng D, Luo M, Xie R, Yang K, Xu D, Yang K, Fei J, Zhou T
Biochemical and biophysical research communications 2019 Nov 12;519(3):620-625
Biochemical and biophysical research communications 2019 Nov 12;519(3):620-625
Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane.
Farmer T, O'Neill KL, Naslavsky N, Luo X, Caplan S
Molecular biology of the cell 2019 May 1;30(10):1138-1146
Molecular biology of the cell 2019 May 1;30(10):1138-1146
The role of ZBTB38 in promoting migration and invasive growth of bladder cancer cells.
Jing J, Liu J, Wang Y, Zhang M, Yang L, Shi F, Liu P, She J
Oncology reports 2019 Mar;41(3):1980-1990
Oncology reports 2019 Mar;41(3):1980-1990
Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration.
Zhang J, Zhang C, Jiang X, Li L, Zhang D, Tang D, Yan T, Zhang Q, Yuan H, Jia J, Hu J, Zhang J, Huang Y
Cell death & disease 2019 Mar 8;10(3):234
Cell death & disease 2019 Mar 8;10(3):234
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.
Liu J, Zhang X, Chen K, Cheng Y, Liu S, Xia M, Chen Y, Zhu H, Li Z, Cao X
Immunity 2019 Mar 19;50(3):600-615.e15
Immunity 2019 Mar 19;50(3):600-615.e15
Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop.
Wang Y, Chen J, Yang L, Li J, Wu W, Huang M, Lin L, Su S
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Mar 15;25(6):1957-1969
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Mar 15;25(6):1957-1969
The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.
Scheiber IF, Wu Y, Morgan SE, Zhao N
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
The Journal of biological chemistry 2019 Jun 7;294(23):9147-9160
Programmable RNA-Guided RNA Effector Proteins Built from Human Parts.
Rauch S, He E, Srienc M, Zhou H, Zhang Z, Dickinson BC
Cell 2019 Jun 27;178(1):122-134.e12
Cell 2019 Jun 27;178(1):122-134.e12
Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.
Hua L, Wu N, Zhao R, He X, Liu Q, Li X, He Z, Yu L, Yan N
International journal of molecular sciences 2019 Jun 12;20(12)
International journal of molecular sciences 2019 Jun 12;20(12)
An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA
Molecular cell 2019 Jul 25;75(2):382-393.e5
Molecular cell 2019 Jul 25;75(2):382-393.e5
Thermoregulation via Temperature-Dependent PGD(2) Production in Mouse Preoptic Area.
Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY
Neuron 2019 Jul 17;103(2):309-322.e7
Neuron 2019 Jul 17;103(2):309-322.e7
MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.
Arifuzzaman M, Mobley YR, Choi HW, Bist P, Salinas CA, Brown ZD, Chen SL, Staats HF, Abraham SN
Science advances 2019 Jan;5(1):eaav0216
Science advances 2019 Jan;5(1):eaav0216
Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism.
Ji Y, Zhang P, Xing Y, Jia L, Zhang Y, Jia T, Wu X, Zhao B, Xu X
International journal of molecular medicine 2019 Jan;43(1):167-176
International journal of molecular medicine 2019 Jan;43(1):167-176
Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes.
Skowrońska K, Obara-Michlewska M, Czarnecka A, Dąbrowska K, Zielińska M, Albrecht J
Neurotoxicity research 2019 Jan;35(1):271-280
Neurotoxicity research 2019 Jan;35(1):271-280
Spinal Serotonin 1A Receptor Contributes to the Analgesia of Acupoint Catgut Embedding by Inhibiting Phosphorylation of the N-Methyl-d-Aspartate Receptor GluN1 Subunit in Complete Freund's Adjuvant-Induced Inflammatory Pain in Rats.
Cui WQ, Sun WS, Xu F, Hu XM, Yang W, Zhou Y, Du LX, Zhang WW, Mao-Ying QL, Mi WL, Chu YX, Wang YQ
The journal of pain 2019 Jan;20(1):16.e1-16.e16
The journal of pain 2019 Jan;20(1):16.e1-16.e16
Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition.
Mattoo AR, Joun A, Jessup JM
Molecular cancer research : MCR 2019 Jan;17(1):42-53
Molecular cancer research : MCR 2019 Jan;17(1):42-53
PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.
Lim V, Zhu H, Diao S, Hu L, Hu J
Biochemical and biophysical research communications 2019 Jan 8;508(2):646-653
Biochemical and biophysical research communications 2019 Jan 8;508(2):646-653
Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway.
Majewska E, Márquez J, Albrecht J, Szeliga M
Cancers 2019 Jan 19;11(1)
Cancers 2019 Jan 19;11(1)
Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells.
Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, Huang X, Liu Y, Wang J, Dougherty U, Bissonnette MB, Shen B, Weichselbaum RR, Xu MM, He C
Nature 2019 Feb;566(7743):270-274
Nature 2019 Feb;566(7743):270-274
Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs.
Wei DM, Jiang MT, Lin P, Yang H, Dang YW, Yu Q, Liao DY, Luo DZ, Chen G
International journal of oncology 2019 Feb;54(2):600-626
International journal of oncology 2019 Feb;54(2):600-626
MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.
Qu W, Wen X, Su K, Gou W
Journal of cellular and molecular medicine 2019 Feb;23(2):1541-1552
Journal of cellular and molecular medicine 2019 Feb;23(2):1541-1552
Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells.
Liu S, Hou H, Zhang P, Wu Y, He X, Li H, Yan N
Molecular medicine reports 2019 Feb;19(2):1159-1167
Molecular medicine reports 2019 Feb;19(2):1159-1167
Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.
Yang J, Zhang X, Chen Z, Shen Y, Wang F, Wang Y, Liu Y, Liu P, Yang J
Cell death & disease 2019 Feb 21;10(3):179
Cell death & disease 2019 Feb 21;10(3):179
Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.
He Y, Lin Y, Zhu Y, Ping P, Wang G, Sun F
Biology of reproduction 2019 Feb 1;100(2):561-572
Biology of reproduction 2019 Feb 1;100(2):561-572
Rutin promotes the formation and osteogenic differentiation of human periodontal ligament stem cell sheets in vitro.
Zhao B, Zhang Y, Xiong Y, Xu X
International journal of molecular medicine 2019 Dec;44(6):2289-2297
International journal of molecular medicine 2019 Dec;44(6):2289-2297
A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability.
Xia B, Hong T, He X, Hu X, Gao Y
Cell transplantation 2019 Dec;28(12):1614-1623
Cell transplantation 2019 Dec;28(12):1614-1623
Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery.
Wu N, Yuan Z, Du KY, Fang L, Lyu J, Zhang C, He A, Eshaghi E, Zeng K, Ma J, Du WW, Yang BB
Cell death and differentiation 2019 Dec;26(12):2758-2773
Cell death and differentiation 2019 Dec;26(12):2758-2773
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS
Nature immunology 2019 Dec;20(12):1644-1655
Nature immunology 2019 Dec;20(12):1644-1655
LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription.
Xiu B, Chi Y, Liu L, Chi W, Zhang Q, Chen J, Guo R, Si J, Li L, Xue J, Shao ZM, Wu ZH, Huang S, Wu J
Molecular cancer 2019 Dec 19;18(1):187
Molecular cancer 2019 Dec 19;18(1):187
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.
Chong KY, Kang M, Garofalo F, Ueno D, Liang H, Cady S, Madarikan O, Pitruzzello N, Tsai CH, Hartwich TMP, Shuch BM, Yang-Hartwich Y
Molecular pharmacology 2019 Aug;96(2):168-179
Molecular pharmacology 2019 Aug;96(2):168-179
Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA) Requires Death Receptor Fas, in Addition to LFA-1, To Trigger Cell Death in T Lymphocytes.
Vega BA, Schober LT, Kim T, Belinka BA Jr, Kachlany SC
Infection and immunity 2019 Aug;87(8)
Infection and immunity 2019 Aug;87(8)
Palmitoylation is required for TNF-R1 signaling.
Zingler P, Särchen V, Glatter T, Caning L, Saggau C, Kathayat RS, Dickinson BC, Adam D, Schneider-Brachert W, Schütze S, Fritsch J
Cell communication and signaling : CCS 2019 Aug 5;17(1):90
Cell communication and signaling : CCS 2019 Aug 5;17(1):90
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Fons NR, Sundaram RK, Breuer GA, Peng S, McLean RL, Kalathil AN, Schmidt MS, Carvalho DM, Mackay A, Jones C, Carcaboso ÁM, Nazarian J, Berens ME, Brenner C, Bindra RS
Nature communications 2019 Aug 22;10(1):3790
Nature communications 2019 Aug 22;10(1):3790
Mutations in topoisomerase IIβ result in a B cell immunodeficiency.
Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM
Nature communications 2019 Aug 13;10(1):3644
Nature communications 2019 Aug 13;10(1):3644
CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.
Li K, Meng Z, Jiang L, Xia C, Xu K, Yuan D, Chen H, Zhang B, Liu S
Molecular and cellular probes 2019 Apr;44:57-62
Molecular and cellular probes 2019 Apr;44:57-62
BP‑1‑102 exerts an antitumor effect on the AGS human gastric cancer cell line through modulating the STAT3 and MAPK signaling pathways.
Jiang X, Tang J, Wu M, Chen S, Xu Z, Wang H, Wang H, Yu X, Li Z, Teng L
Molecular medicine reports 2019 Apr;19(4):2698-2706
Molecular medicine reports 2019 Apr;19(4):2698-2706
Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production.
Kotredes KP, Razmpour R, Lutton E, Alfonso-Prieto M, Ramirez SH, Gamero AM
Oncotarget 2019 Apr 12;10(28):2675-2692
Oncotarget 2019 Apr 12;10(28):2675-2692
miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
Monteleone NJ, Moore AE, Iacona JR, Lutz CS, Dixon DA
Scientific reports 2019 Apr 1;9(1):5405
Scientific reports 2019 Apr 1;9(1):5405
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
Gou Y, Li X, Li P, Zhang H, Xu T, Wang H, Wang B, Ma X, Jiang X, Zhang Z
Human reproduction (Oxford, England) 2019 Apr 1;34(4):646-658
Human reproduction (Oxford, England) 2019 Apr 1;34(4):646-658
FEZF1 is an Independent Predictive Factor for Recurrence and Promotes Cell Proliferation and Migration in Cervical Cancer.
Lan Y, Xiao X, Luo Y, He Z, Song X
Journal of Cancer 2018;9(21):3929-3938
Journal of Cancer 2018;9(21):3929-3938
Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer.
Xiang Z, Huang X, Wang J, Zhang J, Ji J, Yan R, Zhu Z, Cai W, Yu Y
Frontiers in pharmacology 2018;9:861
Frontiers in pharmacology 2018;9:861
Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.
Li X, Qiu Z, Jin Q, Chen G, Guo M
Frontiers in pharmacology 2018;9:629
Frontiers in pharmacology 2018;9:629
Decrease of Perivascular Adipose Tissue Browning Is Associated With Vascular Dysfunction in Spontaneous Hypertensive Rats During Aging.
Kong LR, Zhou YP, Chen DR, Ruan CC, Gao PJ
Frontiers in physiology 2018;9:400
Frontiers in physiology 2018;9:400
Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A.
Zhou J, Zhang C, Zheng GH, Qiu Z
Evidence-based complementary and alternative medicine : eCAM 2018;2018:8478943
Evidence-based complementary and alternative medicine : eCAM 2018;2018:8478943
The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer.
Li J, Liu J, Li P, Zhou C, Liu P
Experimental biology and medicine (Maywood, N.J.) 2018 Sep;243(13):1066-1073
Experimental biology and medicine (Maywood, N.J.) 2018 Sep;243(13):1066-1073
m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Liu J, Eckert MA, Harada BT, Liu SM, Lu Z, Yu K, Tienda SM, Chryplewicz A, Zhu AC, Yang Y, Huang JT, Chen SM, Xu ZG, Leng XH, Yu XC, Cao J, Zhang Z, Liu J, Lengyel E, He C
Nature cell biology 2018 Sep;20(9):1074-1083
Nature cell biology 2018 Sep;20(9):1074-1083
A(2A) Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21.
Ruan CC, Kong LR, Chen XH, Ma Y, Pan XX, Zhang ZB, Gao PJ
Cell metabolism 2018 Sep 4;28(3):476-489.e5
Cell metabolism 2018 Sep 4;28(3):476-489.e5
Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors.
Lopez Sambrooks C, Baro M, Quijano A, Narayan A, Cui W, Greninger P, Egan R, Patel A, Benes CH, Saltzman WM, Contessa JN
Cancer research 2018 Sep 1;78(17):5094-5106
Cancer research 2018 Sep 1;78(17):5094-5106
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
Yu G, Liao J, Wu J, Ding J, Zhang L
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
Bioscience, biotechnology, and biochemistry 2018 Oct;82(10):1694-1701
Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways.
Wang S, Wei J, Fan Y, Ding H, Tian H, Zhou X, Cheng L
Inflammation 2018 Oct;41(5):1852-1863
Inflammation 2018 Oct;41(5):1852-1863
Loss of miR-146b-3p Inhibits Perivascular Adipocyte Browning with Cold Exposure During Aging.
Pan XX, Cao JM, Cai F, Ruan CC, Wu F, Gao PJ
Cardiovascular drugs and therapy 2018 Oct;32(5):511-518
Cardiovascular drugs and therapy 2018 Oct;32(5):511-518
Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.
Xia Y, Yu B, Ma C, Tu Y, Zhai L, Yang Y, Liu D, Liu Y, Wu H, Dan H, You P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1332-1338
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1332-1338
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Su S, Zhao J, Xing Y, Zhang X, Liu J, Ouyang Q, Chen J, Su F, Liu Q, Song E
Cell 2018 Oct 4;175(2):442-457.e23
Cell 2018 Oct 4;175(2):442-457.e23
Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.
Rinis N, Golden JE, Marceau CD, Carette JE, Van Zandt MC, Gilmore R, Contessa JN
Cell chemical biology 2018 Oct 18;25(10):1231-1241.e4
Cell chemical biology 2018 Oct 18;25(10):1231-1241.e4
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.
Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA
The Journal of clinical investigation 2018 Oct 1;128(10):4682-4696
The Journal of clinical investigation 2018 Oct 1;128(10):4682-4696
Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning.
Mao M, Hu Y, Yang Y, Qian Y, Wei H, Fan W, Yang Y, Li X, Wang Z
Cell systems 2018 Nov 28;7(5):510-520.e4
Cell systems 2018 Nov 28;7(5):510-520.e4
Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance.
Jiang B, Lv Q, Wan W, Le L, Xu L, Hu K, Xiao P
Food & function 2018 Nov 14;9(11):5607-5620
Food & function 2018 Nov 14;9(11):5607-5620
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
Zhao N, Liang P, Zhuo X, Su C, Zong X, Guo B, Han D, Yan X, Hu S, Zhang Q, Tie X
Basic & clinical pharmacology & toxicology 2018 May;122(5):470-480
Basic & clinical pharmacology & toxicology 2018 May;122(5):470-480
PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
Papadopoulos N, Lennartsson J, Heldin CH
The Journal of cell biology 2018 May 7;217(5):1701-1717
The Journal of cell biology 2018 May 7;217(5):1701-1717
β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.
Ahmed KM, Pandita RK, Singh DK, Hunt CR, Pandita TK
Molecular and cellular biology 2018 May 1;38(9)
Molecular and cellular biology 2018 May 1;38(9)
hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1.
He X, Fan S
Oncology reports 2018 Mar;39(3):977-984
Oncology reports 2018 Mar;39(3):977-984
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.
Lan Y, Xiao X, He Z, Luo Y, Wu C, Li L, Song X
Nucleic acids research 2018 Jun 20;46(11):5809-5821
Nucleic acids research 2018 Jun 20;46(11):5809-5821
miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.
Iacona JR, Monteleone NJ, Lutz CS
Oncotarget 2018 Jun 1;9(42):26751-26769
Oncotarget 2018 Jun 1;9(42):26751-26769
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.
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European journal of immunology 2018 Jul;48(7):1120-1136
European journal of immunology 2018 Jul;48(7):1120-1136
Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9.
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Journal of cellular and molecular medicine 2018 Jul;22(7):3423-3433
Journal of cellular and molecular medicine 2018 Jul;22(7):3423-3433
Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.
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Cell reports 2018 Jul 24;24(4):895-908.e6
Cell reports 2018 Jul 24;24(4):895-908.e6
mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways.
Yu J, Yang H, Fang B, Zhang Z, Wang Y, Dai Y
Journal of neuroscience research 2018 Jan;96(1):87-102
Journal of neuroscience research 2018 Jan;96(1):87-102
Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea.
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Experimental and therapeutic medicine 2018 Jan;15(1):993-998
Experimental and therapeutic medicine 2018 Jan;15(1):993-998
Tumor necrosis factor-alpha inhibits osteogenic differentiation of pre-osteoblasts by downregulation of EphB4 signaling via activated nuclear factor-kappaB signaling pathway.
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Journal of periodontal research 2018 Feb;53(1):66-72
Journal of periodontal research 2018 Feb;53(1):66-72
CD10(+)GPR77(+) Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness.
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Cell 2018 Feb 8;172(4):841-856.e16
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Autoimmunity 2018 Dec;51(8):399-407
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International journal of molecular medicine 2018 Dec;42(6):3344-3354
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PLoS genetics 2018 Dec;14(12):e1007846
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An In Vitro Comparative Study of Multisource Derived Human Mesenchymal Stem Cells for Bone Tissue Engineering.
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Oncology reports 2018 Apr;39(4):1693-1701
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Journal of cellular and molecular medicine 2018 Apr;22(4):2390-2403
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The Journal of biological chemistry 2018 Apr 27;293(17):6517-6529
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Journal of biomedical research 2017 Sep 26;31(5):445-452
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Chen HY, Huang TC, Shieh TM, Wu CH, Lin LC, Hsia SM
International journal of molecular sciences 2017 Sep 21;18(10)
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Diabetes 2017 Oct;66(10):2681-2690
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International journal of molecular sciences 2017 Nov 2;18(11)
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Scientific reports 2017 Mar 27;7:45275
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Scientific reports 2017 Mar 14;7:44507
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MTA1 promotes epithelial to mesenchymal transition and metastasis in non-small-cell lung cancer.
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Oncology reports 2017 Jul;38(1):109-119
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Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
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Cell 2017 Jul 27;170(3):492-506.e14
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Archives of pharmacal research 2014 Aug;37(8):1086-95
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Western blot analysis of GAPDH in various tissues and cell lines using Proteintech antibody HRP-60004 at a dilution of 1:10000.
- Sample type
- tissue
