11760-1-AP

antibody from Proteintech Group

Targeting: HNRNPC HNRPC

Provider product page for 11760-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [59]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 11760-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11760-1-AP, RRID:AB_2117500
Product name: HNRNPC antibody
Antibody type: Polyclonal
Description: KD/KO validated HNRNPC antibody (Cat. #11760-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HNRNPC protein structure - 11760-1-AP shown in red.

Submitted references MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids.

Uhl L, Aziba A, Löbbert S, Russell T, Krenz B, Montesinos F, Kannan T, Valanju OR, Schülein-Völk C, de Martines T, Bolz M, Fleischhauer D, Cossa G, Endres T, Solvie D, Gallant P, Rosenwald A, Maric HM, Papadopoulos D, Vos SM, Eilers M
Cell 2026 Mar 5;189(5):1371-1388.e29

Suppression of LRRC41-mediated oncogenicity in hepatocellular carcinoma via USP7-targeted small molecule inhibitors.

Huang Y, Xi Y, Nie H, Wang Y, Hu J, Gao Y, Li J, Ma Y, Chu J, Tu L, Huang D, Cheng L
British journal of cancer 2026 Jun;134(11):1658-1670

Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.

Gao X, Zhang J, Lin Y, Tian K, Tu J, Wu Z, Lv X, Hu H, Liu X, Lin S, Zhu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688

HNRNPC Promotes Keloid Progression by Modulating the Stability of N(6)-Methyladenosine-Modified WDR77 mRNA and Expression of TGF-β and SMAD3.

Zhan Y, Zeng N, Yu J, Wu Y, Zhu K, Yang Z, Guo X, Zhang Q, Liu Z
The Journal of investigative dermatology 2026 Jan;146(1):236-248.e6

CUL5 E3 ubiquitin ligase regulates the evasion of bladder cancer cells to CD8+ T cell-mediated killing by inhibiting autophagy.

Gao X, Yu Y, Sun J, Zhao H, You Y, Shi X, Wang K, Hong S, Xiong X, Huang C, Zhang H, Jiang G
PLoS biology 2026 Feb;24(2):e3003647

m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.

Yin L, Zhang Y, Zhang B, Zhang J, Xiong M, Jiang N, Xiao J, Gao H, Xiong W, Wang X, Wang F, Yuan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600

The molecular chaperone TRAP1 promotes translation of Luc7I3 mRNA to enhance ovarian cancer cell proliferation.

De Lella S, Pedalino L, Abaker MAA, Mignogna C, Cautiero R, Esposito F, Matassa DS, Avolio R
RNA (New York, N.Y.) 2025 Oct 16;31(11):1667-1683

m6A-induced DEAD-box RNA helicase 21 enhances lipid metabolism via 3‑hydroxy-3-methylglutaryl-CoA synthases 1 in colorectal cancer.

Gao H, Zheng S, Liang J, Wang Y, Chen L, Li H, Chen Y, Zhang F, Shi H, Han A
Translational oncology 2025 May;55:102373

Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m(6)A modification in triple-negative breast cancer.

Yu Y, Hu J, Wang W, Lei H, Xi Z, Zhang P, Zhao E, Lu C, Chen H, Liu C, Li L
Science advances 2025 May 9;11(19):eadr3173

RALYL Overexpression Suppresses Colorectal Cancer via Modulating HNRNPC-Mediated MNK2 Alternative Splicing.

Ma Z, Zhu J, Chen M, Wu G, Liu X, Hu Z, Feng Y, Wang X, Liu F
Cancer reports (Hoboken, N.J.) 2025 Mar;8(3):e70179

Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity.

Wang X, Wang Z, Wang J, Yu Y, Wang Y, Xiong Z, Han S, Zhong XB, Wang P, Zhang L
Molecular pharmacology 2025 Mar;107(3):100021

HNRNPC promotes progression of non-small cell lung cancer by maintaining TFAP2A mRNA stability.

Liao M, Li C, Yang R, Li J, Wu K, Zhang J, Zhu Q, Shi Y, Zhang X
Cancer cell international 2025 Mar 8;25(1):85

The m6A reader HNRNPC is a key regulator in DSS-induced colitis by modulating macrophage phenotype.

Fang X, Zhang Y, Ke Z, Zhang Y, Lin Y, Huang Y, Zhou J, Su H, Xu J, Liu Y
iScience 2025 Mar 21;28(3):111812

YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks.

Tsao N, Lombardi PM, Park A, Olabode J, Rodell R, Sun H, Padmanaban S, Brickner JR, Tsai MS, Pollina EA, Chen CK, Mosammaparast N
Molecular cell 2025 Mar 20;85(6):1085-1100.e9

Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1.

Stok JE, van der Kooij SB, Gravekamp D, Ter Haar LR, de Wolf JW, Salgado-Benvindo C, Nelemans T, Grijmans BJM, Tjokrodirijo RTN, de Ru AH, van Veelen PA, van Hemert MJ, Kikkert M, van der Veen AG
Cell reports 2025 Jun 24;44(6):115823

Long Noncoding RNA CCDC26 Interacts With Vimentin, HNRNPC, CBX1, and CBX5 Proteins in Multiple Intracellular Compartments of Myeloid Leukemia Cells.

Tanaka Y, Ishida A, Harada H, Hirano T
Genes to cells : devoted to molecular & cellular mechanisms 2025 Jul;30(4):e70034

IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.

Luo X, Wei Q, Xie L, Chen N, Gu B, Xu J, Jiang X, Zuo X, Zhao H, Liu X, Yang Y, Liu T, Zhu Y, Yi P, Xu J
Clinical and translational medicine 2025 Jul;15(7):e70388

M6A-dependent RNA condensation underlies FUS autoregulation and can be harnessed for ALS therapy development.

Huang WP, Kumar V, Yap K, An H, John SJ, Hodgson RE, Avila AS, Day E, Ellis BCS, Chung TH, Lord J, Müller-McNicoll M, Makeyev EV, Shelkovnikova TA
Science advances 2025 Jul 25;11(30):eadx1357

Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation.

Wang Q, Gou X, Liu L, Deng D, Zhao Y, Zhou J, Xie Y, Jiang Y, Li J, Zhang J, Liu Y
Cancer cell international 2025 Jan 13;25(1):10

HNRNPC-Mediated m6A Epitranscriptomics Drives CD80-Dependent Tubular Dysfunction in Sepsis-Induced AKI.

Juan C, Zhao X, Wang Y, Chen D, Yu M, Mao Y
Inflammation 2025 Dec;48(6):4591-4607

Snhg18 regulates Yap subcellular localization to maintain bone homeostasis.

Huang J, Weng Y, Feng Y, Wu D, Chen Y, Li Z, Jiang X, Wang H, Wang Z
Nature communications 2025 Aug 14;16(1):7543

Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD.

Xie L, Zhu Y, Hurtle BT, Wright M, Robinson JL, Mauna JC, Brown EE, Ngo M, Bergmann CA, Xu J, Merjane J, Gleixner AM, Grigorean G, Liu F, Rossoll W, Lee EB, Kiskinis E, Chikina M, Donnelly CJ
bioRxiv : the preprint server for biology 2025 Apr 9;

Evidence for the potential role of m6A modification in regulating autophagy in models of amyotrophic lateral sclerosis.

An D, Han J, Fang P, Bu Y, Ji G, Liu M, Deng J, Song X
CytoJournal 2024;21:33

O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export.

Liu S, Lv Q, Mao X, Dong H, Xu W, Du X, Jia W, Feng K, Zhang J, Zhang Y
International journal of biological sciences 2024;20(9):3675-3690

TGF-β-induced lncRNA TBUR1 promotes EMT and metastasis in lung adenocarcinoma via hnRNPC-mediated GRB2 mRNA stabilization.

Huang L, Liu X, Chen Q, Yang J, Zhang D, Zhao Y, Xu L, Li Z, Liu X, Shao S, Li D, Song Y, Liu X, Zhan Q
Cancer letters 2024 Sep 28;600:217153

Upregulation of Long Noncoding RNA MAGOH-DT Mediates TNF-α and High Glucose-Induced Endothelial-Mesenchymal Transition in Arteriosclerosis Obliterans.

Wang KJ, Zhang YX, Mo ZW, Li ZL, Wang M, Wang R, Wang ZC, Chang GQ, Wu WB
The Tohoku journal of experimental medicine 2024 Sep 27;263(4):227-238

HNRNPC mediates lymphatic metastasis of cervical cancer through m6A-dependent alternative splicing of FOXM1.

Liu YY, Xia M, Chen ZB, Liao YD, Zhang CY, Yuan L, Pan YW, Huang H, Lu HW, Yao SZ
Cell death & disease 2024 Oct 7;15(10):732

m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma.

Xu X, Wu S, Zhang Y, Fan W, Lin X, Chen K, Lin X
Molecular carcinogenesis 2024 Nov;63(11):2174-2189

N6-Methyladenosine reader HNRNPC-mediated downregulation of circITCH prevents miR-224-3p sequestering and contributes to tumorigenesis in nasopharyngeal carcinoma.

Zhou Q, Song W, Li X, Lin J, Zhu C, Cao L, Li W, Lin S
Environmental toxicology 2024 May;39(5):2893-2907

The significance of m6A RNA methylation regulators in diagnosis and subtype classification of HBV-related hepatocellular carcinoma.

Zang Q, Ju Y, Liu S, Wu S, Zhu C, Liu L, Xu W, He Y
Human cell 2024 May;37(3):752-767

The m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway.

Chen JJ, Lu TZ, Wang T, Yan WH, Zhong FY, Qu XH, Gong XC, Li JG, Tou FF, Jiang LP, Han XJ
Cell death & disease 2024 Jun 3;15(6):390

Stress-induced TDP-43 nuclear condensation causes splicing loss of function and STMN2 depletion.

Huang WP, Ellis BCS, Hodgson RE, Sanchez Avila A, Kumar V, Rayment J, Moll T, Shelkovnikova TA
Cell reports 2024 Jul 23;43(7):114421

Dysregulated inclusion of BOLA3 exon 3 promoted by HNRNPC accelerates the progression of esophageal squamous cell carcinoma.

Tian B, Bian Y, Pang Y, Gao Y, Yu C, Zhang X, Zhou S, Li Z, Xin L, Lin H, Wang L
Frontiers of medicine 2024 Dec;18(6):1035-1053

Loss of MIR503HG facilitates papillary renal cell carcinoma associated lymphatic metastasis by triggering NOTCH1/VEGFC signaling.

Wang Y, Zheng X, Huang W, Lu J, Hou N, Qi J, Ma J, Xue W, Zheng J, Zhai W
International journal of biological sciences 2023;19(10):3266-3284

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing.

Vital T, Wali A, Butler KV, Xiong Y, Foster JP 2nd, Marcel SS, McFadden AW, Nguyen VU, Bailey BM, Lamb KN, James LI, Frye SV, Mosely AL, Jin J, Pattenden SG, Davis IJ
Frontiers in oncology 2023;13:1099550

Exploring the role of m6A methylation regulators in glioblastoma multiforme and their impact on the tumor immune microenvironment.

Deng X, Sun X, Hu Z, Wu Y, Zhou C, Sun J, Gao X, Huang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23155

A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.

Wang L, Ji Y, Chen Y, Bai J, Gao P, Feng P
Human molecular genetics 2023 Mar 6;32(6):971-983

LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.

Chen QW, Cai QQ, Yang Y, Dong S, Liu YY, Chen ZY, Kang CL, Qi B, Dong YW, Wu W, Zhuang LP, Shen YH, Meng ZQ, Wu XZ
Clinical and translational medicine 2023 Jan;13(1):e1129

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116

Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress.

Ghanam AR, Ke S, Wang S, Elgendy R, Xie C, Wang S, Zhang R, Wei M, Liu W, Cao J, Zhang Y, Zhang Z, Xue T, Zheng Y, Song X
iScience 2023 Jan 20;26(1):105740

LncRNA CALML3-AS1 modulated by m(6)A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression.

Zhang H, Wang SQ, Zhu JB, Wang LN, Lin H, Li LF, Cheng YD, Duan CJ, Zhang CF
Cancer gene therapy 2023 Dec;30(12):1649-1662

m6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia.

Wu Z, Zuo X, Zhang W, Li Y, Gui R, Leng J, Shen H, Pan B, Fan L, Li J, Jin H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2304895

HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder.

Niggl E, Bouman A, Briere LC, Hoogenboezem RM, Wallaard I, Park J, Admard J, Wilke M, Harris-Mostert EDRO, Elgersma M, Bain J, Balasubramanian M, Banka S, Benke PJ, Bertrand M, Blesson AE, Clayton-Smith J, Ellingford JM, Gillentine MA, Goodloe DH, Haack TB, Jain M, Krantz I, Luu SM, McPheron M, Muss CL, Raible SE, Robin NH, Spiller M, Starling S, Sweetser DA, Thiffault I, Vetrini F, Witt D, Woods E, Zhou D, Genomics England Research Consortium, Undiagnosed Diseases Network, Elgersma Y, van Esbroeck ACM
American journal of human genetics 2023 Aug 3;110(8):1414-1435

Essential m(6)A Methylation Regulator HNRNPC Serves as a Targetable Biomarker for Papillary Renal Cell Carcinoma.

Wu J, Wei Y, Miao C, Wang S, Wang X, Wang Z
Journal of oncology 2022;2022:9411692

Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation.

Liu Y, Wang X, Zeng X, Wu Y, Liu X, Tan J, Li X
Open medicine (Warsaw, Poland) 2022;17(1):1183-1202

The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma.

Li Y, Wang H, Wan J, Ma Q, Qi Y, Gu Z
Frontiers in oncology 2022;12:845931

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131

Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS.

Tsai YL, Mu YC, Manley JL
Scientific reports 2022 May 17;12(1):8180

Alternative polyadenylation by sequential activation of distal and proximal PolyA sites.

Tang P, Yang Y, Li G, Huang L, Wen M, Ruan W, Guo X, Zhang C, Zuo X, Luo D, Xu Y, Fu XD, Zhou Y
Nature structural & molecular biology 2022 Jan;29(1):21-31

Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma.

Wang Y, Zhao X, Li J, Wang X, Hu W, Zhang X
Technology in cancer research & treatment 2022 Jan-Dec;21:15330338221085373

METTL3 regulates heterochromatin in mouse embryonic stem cells.

Xu W, Li J, He C, Wen J, Ma H, Rong B, Diao J, Wang L, Wang J, Wu F, Tan L, Shi YG, Shi Y, Shen H
Nature 2021 Mar;591(7849):317-321

A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.

Wu X, Sheng H, Wang L, Xia P, Wang Y, Yu L, Lv W, Hu J
Aging 2021 Mar 26;13(7):10034-10057

Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway.

Khan M, Hou S, Azam S, Lei H
Nucleic acids research 2021 Jun 21;49(11):6420-6436

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.

Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9

Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression.

Lv W, Tan Y, Xiong M, Zhao C, Wang Y, Wu M, Wu Y, Zhang Q
Journal of translational medicine 2021 Dec 24;19(1):527

hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.

Akinyemi AR, Li D, Zhang J, Liu Q
Neuroscience letters 2021 Apr 23;751:135824

M6A RNA Methylation Regulator HNRNPC Contributes to Tumorigenesis and Predicts Prognosis in Glioblastoma Multiforme.

Wang LC, Chen SH, Shen XL, Li DC, Liu HY, Ji YL, Li M, Yu K, Yang H, Chen JJ, Qin CZ, Luo MM, Lin QX, Lv QL
Frontiers in oncology 2020;10:536875

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644

An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.

Su CC, Su JH, Lin JJ, Chen CC, Hwang WI, Huang HH, Wu YJ
Marine drugs 2011 Dec;9(12):2622-2642

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11760-1-AP(HNRNPC antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using HNRNPC antibody 11760-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line