ABIN361718

Teigen LE, Orczewska JI, McLaughlin J, O'Brien KM
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2015 Oct;188:139-47

Hsp90α and Hsp90β together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing.

Jayaprakash P, Dong H, Zou M, Bhatia A, O'Brien K, Chen M, Woodley DT, Li W
Journal of cell science 2015 Apr 15;128(8):1475-80

Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells.

Hunter MC, O'Hagan KL, Kenyon A, Dhanani KC, Prinsloo E, Edkins AL
PloS one 2014;9(1):e86842

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.

Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G
Nature chemical biology 2013 Nov;9(11):677-84

HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience.

Espallergues J, Teegarden SL, Veerakumar A, Boulden J, Challis C, Jochems J, Chan M, Petersen T, Deneris E, Matthias P, Hahn CG, Lucki I, Beck SG, Berton O
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Mar 28;32(13):4400-16

A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.

Chen Q, Prior M, Dargusch R, Roberts A, Riek R, Eichmann C, Chiruta C, Akaishi T, Abe K, Maher P, Schubert D
PloS one 2011;6(12):e27865

Design, synthesis, and evaluation of small molecule Hsp90 probes.

Taldone T, Zatorska D, Patel PD, Zong H, Rodina A, Ahn JH, Moulick K, Guzman ML, Chiosis G
Bioorganic & medicinal chemistry 2011 Apr 15;19(8):2603-14

Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization.

Gershburg S, Murphy L, Marschall M, Gershburg E
The Biochemical journal 2010 Oct 15;431(2):227-35

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.

Pratt WB, Toft DO
Experimental biology and medicine (Maywood, N.J.) 2003 Feb;228(2):111-33

Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress.

Arlander SJ, Eapen AK, Vroman BT, McDonald RJ, Toft DO, Karnitz LM
The Journal of biological chemistry 2003 Dec 26;278(52):52572-7

Hsp90 inhibitors as novel cancer chemotherapeutic agents.

Neckers L
Trends in molecular medicine 2002;8(4 Suppl):S55-61

Structure, function, and mechanism of the Hsp90 molecular chaperone.

Pearl LH, Prodromou C
Advances in protein chemistry 2001;59:157-86

Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes.

Barent RL, Nair SC, Carr DC, Ruan Y, Rimerman RA, Fulton J, Zhang Y, Smith DF
Molecular endocrinology (Baltimore, Md.) 1998 Mar;12(3):342-54

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome.

Loo MA, Jensen TJ, Cui L, Hou Y, Chang XB, Riordan JR
The EMBO journal 1998 Dec 1;17(23):6879-87

The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors.

Pratt WB
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1998 Apr;217(4):420-34

Domain structures and immunogenic regions of the 90-kDa heat-shock protein (HSP90). Probing with a library of anti-HSP90 monoclonal antibodies and limited proteolysis.

Nemoto T, Sato N, Iwanari H, Yamashita H, Takagi T
The Journal of biological chemistry 1997 Oct 17;272(42):26179-87

Steroid receptor interactions with heat shock protein and immunophilin chaperones.

Pratt WB, Toft DO
Endocrine reviews 1997 Jun;18(3):306-60

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM
Proceedings of the National Academy of Sciences of the United States of America 1994 Aug 30;91(18):8324-8

Analysis of native forms and isoform compositions of the mouse 90-kDa heat shock protein, HSP90.

Minami Y, Kawasaki H, Miyata Y, Suzuki K, Yahara I
The Journal of biological chemistry 1991 Jun 5;266(16):10099-103

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Experimental details: WB