Antibody data
- Antibody Data
- Antigen structure
- References [53]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11405-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11405-1-AP, RRID:AB_2121207
- Product name
- HSP90AB1 antibody
- Antibody type
- Polyclonal
- Description
- HSP90AB1 antibody (Cat. #11405-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Carp protamine as a natural macromolecule for liver cancer risk reduction: Gastrointestinal bioactive peptides induce apoptosis.
VISTA promotes ovarian cancer progression through activation of NF-κB pathway and tumor microenvironment reprogramming.
Puerarin and DHEA combination therapy alleviates primary dysmenorrhea via inhibition of the Hsp90ab1/p38/JNK pathway.
HSP90AB1-Mediated Ubiquitin-Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress-Induced Autophagy.
Small Molecule Screening Identifies HSP90 as a Modifier of RNA Foci in Myotonic Dystrophy Type 1.
Insect-borne non-enveloped bluetongue virus utilizes discrete small vesicles for non-lytic release and cell-to-cell transmission.
Anti PD-L1 immunotherapy alters macrophage phenotypes via EGR1 and HSP90AB1 supported by integrated methodologies.
Dendrobin A inhibits gastric cancer: Mechanistic insights supported by integrated evidence.
Oleanolic acid alleviates ulcerative colitis by remodeling Th17 cells via targeting HSP90β-ODC1 pathway-mediated polyamine synthesis.
Lithium carbonate exposure disrupts neurodevelopment by perturbing primary cilia and ER homeostasis.
Dehydroepiandrosterone ameliorates primary dysmenorrhea by suppressing the SP1/Hsp90ab1/COX-2 signaling pathway.
Toxoplasma gondii infection of neurons alters the production and content of extracellular vesicles directing astrocyte phenotype and contributing to the loss of GLT-1 in the infected brain.
Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy.
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LGR5 interacts with HSP90AB1 to mediate enzalutamide resistance by activating the WNT/β-catenin/AR axis in prostate cancer.
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
METTL14-mediated N6-methyladenosine modification of TCP1 mRNA promotes acute myeloid leukemia progression.
Celastrol attenuates the invasion and migration and augments the anticancer effects of olaparib in prostate cancer.
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons.
HSP90AB1 is a host factor that promotes porcine deltacoronavirus replication.
The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis.
Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression.
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Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer.
DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress.
9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.
Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.
PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer.
N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.
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EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer.
A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection.
Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.
HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma.
HSP90 inhibitors 17-AAG and VER-82576 inhibit porcine deltacoronavirus replication in vitro.
Targeting the lncMST-EPRS/HSP90AB1 complex as novel therapeutic strategy for T-2 toxin-induced growth retardation.
Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines.
GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation.
Induction of autophagy and suppression of type I IFN secretion by CSFV.
A non-enveloped arbovirus released in lysosome-derived extracellular vesicles induces super-infection exclusion.
Osteoking improves OP rat by enhancing HSP90‑β expression.
Solvent-Induced Protein Precipitation for Drug Target Discovery on the Proteomic Scale.
Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity.
Hsp90 Chaperones Bluetongue Virus Proteins and Prevents Proteasomal Degradation.
Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection.
Quantitative proteomic analysis of deer antler stem cells as a model of mammalian organ regeneration.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Phosphoproteome Characterization of Human Colorectal Cancer SW620 Cell-Derived Exosomes and New Phosphosite Discovery for C-HPP.
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DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress.
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PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer.
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The Journal of clinical investigation 2023 Apr 3;133(7)
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Haematologica 2022 Apr 1;107(4):947-957
GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation.
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Pharmacological research 2021 Nov;173:105879
Pharmacological research 2021 Nov;173:105879
Induction of autophagy and suppression of type I IFN secretion by CSFV.
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Autophagy 2021 Apr;17(4):925-947
Autophagy 2021 Apr;17(4):925-947
A non-enveloped arbovirus released in lysosome-derived extracellular vesicles induces super-infection exclusion.
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PLoS pathogens 2020 Oct;16(10):e1009015
PLoS pathogens 2020 Oct;16(10):e1009015
Osteoking improves OP rat by enhancing HSP90‑β expression.
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International journal of molecular medicine 2020 May;45(5):1543-1553
International journal of molecular medicine 2020 May;45(5):1543-1553
Solvent-Induced Protein Precipitation for Drug Target Discovery on the Proteomic Scale.
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Analytical chemistry 2020 Jan 7;92(1):1363-1371
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Cell reports 2020 Feb 11;30(6):1835-1847.e9
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Hsp90 Chaperones Bluetongue Virus Proteins and Prevents Proteasomal Degradation.
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Journal of virology 2019 Oct 15;93(20)
Journal of virology 2019 Oct 15;93(20)
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Zhang LK, Wang B, Xin Q, Shang W, Shen S, Xiao G, Deng F, Wang H, Hu Z, Wang M
Journal of virology 2019 May 15;93(10)
Journal of virology 2019 May 15;93(10)
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Dong Z, Coates D, Liu Q, Sun H, Li C
Journal of proteomics 2019 Mar 20;195:98-113
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Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
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Phosphoproteome Characterization of Human Colorectal Cancer SW620 Cell-Derived Exosomes and New Phosphosite Discovery for C-HPP.
Guo J, Cui Y, Yan Z, Luo Y, Zhang W, Deng S, Tang S, Zhang G, He QY, Wang T
Journal of proteome research 2016 Nov 4;15(11):4060-4072
Journal of proteome research 2016 Nov 4;15(11):4060-4072
Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer.
Zhang L, Yu Z, Wang Y, Wang X, Zhang L, Wang C, Yue Q, Wang X, Deng S, Huo X, Tian X, Huang S, Zhang B, Ma X
Oncotarget 2016 Nov 22;7(47):76551-76564
Oncotarget 2016 Nov 22;7(47):76551-76564
Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.
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European journal of pharmacology 2013 May 15;708(1-3):1-7
European journal of pharmacology 2013 May 15;708(1-3):1-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11405-1-AP(HSP90AB1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunofluorescent analysis of HepG2 cells, using HSP90AB1 antibody 11405-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 11405-1-AP(HSP90AB1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue