11405-1-AP

antibody from Proteintech Group

Targeting: HSP90AB1 HSPC2, HSPCB

Provider product page for 11405-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [29]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 11405-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11405-1-AP, RRID:AB_2121207
Product name: HSP90AB1 antibody
Antibody type: Polyclonal
Description: HSP90AB1 antibody (Cat. #11405-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HSP90AB1 protein structure - 11405-1-AP shown in red.

Submitted references The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis.

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Identification and validation of the surface proteins FIBG, PDGF-β, and TGF-β on serum extracellular vesicles for non-invasive detection of colorectal cancer: experimental study.

Huang Z, Deng C, Ma C, He G, Tao J, Zhang L, Hu X, Mo Y, Qiu L, Zhang N, Luo C, Xing S, Xie J, Yin H
International journal of surgery (London, England) 2024 Aug 1;110(8):4672-4687

DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress.

Lin X, Liu YH, Zhang HQ, Wu LW, Li Q, Deng J, Zhang Q, Yang Y, Zhang C, Li YL, Hu J
Cancer cell international 2023 Sep 23;23(1):208

9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.

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Journal of virology 2023 Mar 30;97(3):e0198422

Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.

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ACS nano 2023 Mar 14;17(5):4261-4278

PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer.

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Journal of translational medicine 2023 Jul 6;21(1):445

N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.

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Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.

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lnc-HC ameliorates steatosis by promoting miR-130b-3p biogenesis and the assembly of an RNA-induced silencing complex.

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Molecular and cellular endocrinology 2023 Dec 1;578:112061

EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer.

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The Journal of clinical investigation 2023 Apr 3;133(7)

A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection.

Zhao Y, Chen R, Xiao D, Zhang L, Song D, Wen Y, Wu R, Zhao Q, Du S, Wen X, Cao S, Huang X
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HSP90AB1 Promotes the Proliferation, Migration, and Glycolysis of Head and Neck Squamous Cell Carcinoma.

Zhang H, Yin X, Zhang X, Zhou M, Xu W, Wei Z, Song C, Han S, Han W
Technology in cancer research & treatment 2022 Jan-Dec;21:15330338221118202

HSP90 inhibitors 17-AAG and VER-82576 inhibit porcine deltacoronavirus replication in vitro.

Zhao Y, Xiao D, Zhang L, Song D, Chen R, Li S, Liao Y, Wen Y, Liu W, Yu E, Wen Y, Wu R, Zhao Q, Du S, Wen X, Cao S, Huang X
Veterinary microbiology 2022 Feb;265:109316

Targeting the lncMST-EPRS/HSP90AB1 complex as novel therapeutic strategy for T-2 toxin-induced growth retardation.

Lu Q, Guo P, Li H, Liu Y, Yuan L, Zhang B, Wu Q, Wang X
Ecotoxicology and environmental safety 2022 Dec 1;247:114243

Comparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines.

Michalik S, Siegerist F, Palankar R, Franzke K, Schindler M, Reder A, Seifert U, Cammann C, Wesche J, Steil L, Hentschker C, Gesell-Salazar M, Reisinger E, Beer M, Endlich N, Greinacher A, Völker U
Haematologica 2022 Apr 1;107(4):947-957

GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation.

Dong Y, Ma N, Fan L, Yuan L, Wu Q, Gong L, Tao Z, Chen J, Ren J
Pharmacological research 2021 Nov;173:105879

Induction of autophagy and suppression of type I IFN secretion by CSFV.

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Hsp90 Chaperones Bluetongue Virus Proteins and Prevents Proteasomal Degradation.

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Journal of virology 2019 Oct 15;93(20)

Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection.

Zhang LK, Wang B, Xin Q, Shang W, Shen S, Xiao G, Deng F, Wang H, Hu Z, Wang M
Journal of virology 2019 May 15;93(10)

Quantitative proteomic analysis of deer antler stem cells as a model of mammalian organ regeneration.

Dong Z, Coates D, Liu Q, Sun H, Li C
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Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.

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Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer.

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Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11405-1-AP(HSP90AB1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using HSP90AB1 antibody 11405-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas cancer using 11405-1-AP(HSP90AB1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue