519101

antibody from BioLegend

Targeting: IL16 FLJ16806, FLJ42735, HsT19289, IL-16, LCF, prIL-16

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

519101

Provider

BioLegend

Proper citation

BioLegend Cat#519101, RRID:AB_11203541

Product name

Purified anti-human IL-16

Antibody type

Monoclonal

Antigen

Peptide corresponding to amino acids 615 to 630 (RRKSLQSKETTAAGDS) of IL-16

Description

Interleukin-16 is a proinflammatory cytokine synthesized as a 68 kD precursor molecule (pro-IL-16). After cleavage of pro-IL-16 by caspase-3, IL-16 is released as a 12 kD protein, but its biologic activities are exerted by a tetramer. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. On T cells, IL-16 upregulates CD25 and class II expression, and also inhibits HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. IL-16 is expressed by lymphocytes, macrophages, eosinophils, mast cells, epithelial cells, and fibroblasts. CD4 and CD9 are the receptors of IL-16.

Reactivity

Human, Simian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

25 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C.