Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 519105 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#519105, RRID:AB_10896422
- Product name
- PE anti-human IL-16
- Antibody type
- Monoclonal
- Antigen
- Peptide corresponding to amino acids 615 to 630 (RRKSLQSKETTAAGDS) of IL-16
- Description
- Interleukin-16 is a proinflammatory cytokine synthesized as a 68 kD precursor molecule (pro-IL-16). After cleavage of pro-IL-16 by caspase-3, IL-16 is released as a 12 kD protein, but its biologic activities are exerted by a tetramer. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. On T cells, IL-16 upregulates CD25 and class II expression, and also inhibits HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. IL-16 is expressed by lymphocytes, macrophages, eosinophils, mast cells, epithelial cells, and fibroblasts. CD4 and CD9 are the receptors of IL-16.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes were surface stained with CD3 APC, and then fixed, permeabilized, and stained with IL-16 (clone 14.1) PE (top) or mouse IgG2a, κ PE (bottom).
- Conjugate
- Yellow dye