Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [132]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 11910-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11910-1-AP, RRID:AB_11182183
- Product name
- HuR antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HuR antibody (Cat. #11910-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Machine Learning and Experimental Validation of m6A RNA Methylation Related Signatures for Risk Prediction, Diagnostic Biomarkers, and Immune Subtypes in Chronic Kidney Disease.
3-Hydroxystearic acid promotes cholesterol efflux and attenuates atherosclerosis via the ALKBH5/PAX-8/ABCA1 pathway.
Regulation of sepsis-associated acute kidney injury by ELAVL1 through USP14/NCOA4-mediated ferroptosis in renal tubular epithelial cells.
ELAVL1 Promotes Proliferation and Inhibits Apoptosis of the Marek's Disease Virus (MDV)-Transformed Cell Line MSB1 via the COX-2/PGE2 Pathway.
ELAVL1 modulates periodontal ligament fibroblast pyroptosis in periodontitis through the JAK2/STAT3/NLRP3 axis.
Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma.
Circular RNA circFNDC3B Modulates M2 Macrophage Activation and Intestinal Inflammation in Crohn's Disease.
Tet2 deficiency-induced expansion of monocyte-derived macrophages promotes liver fibrosis.
BAP31-ELAVL1-SPINK6 axis induces loss of cell polarity and promotes metastasis in hepatocellular carcinoma.
Kuiyangling Enema Alleviates Ulcerative Colitis Mice by Reducing Levels of Intestinal NETs and Promoting HuR/VDR Signaling.
HuR ablation destabilizes Foxp3 mRNA and impairs regulatory T cell function, contributing to an autoimmune phenotype.
Tobacco smoking exposure-mediated ELAVL1 regulates bladder cancer cell senescence via autophagy activation.
Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis-Mediated DNA Repair in Osteosarcoma.
Mycophenolate mofetil inhibits ferroptosis by boosting autophagy to prevent pulmonary fibrosis.
HuB serves as the central hub for connecting HuR-related mRNAs with translation machinery in inflammation.
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
M2 macrophage-derived exosomes promote cell proliferation, migration and EMT of non-small cell lung cancer by secreting miR-155-5p.
LncRNA TUG1 Repressed Angiogenesis by Promoting the Ubiquitination of HuR and Inhibiting Its Nuclear Translocation in Cerebral Ischemic Reperfusion Injury.
Profiling local translatomes and RNA binding proteins of somatosensory neurons reveals specializations of individual axons.
Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer.
The RNA-stability-independent role of the RNA m(6)A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance.
Enhancing mRNA translation efficiency by introducing sequence optimized AU-rich elements in 3' UTR via HuR anchorage.
MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia.
METTL3 facilitates osteoblast differentiation and bone regeneration via m6A-dependent maturation of pri-miR-324-5p.
ELAVL1-mediated USP29 mRNA degradation activates TAK1 driving M1 microglial polarization and neural stem cell differentiation dysregulation in spinal cord injury.
RNA binding protein HuR regulated by OIP5-AS1 may be involved in maternal transcript degradation during the human maternal-to-zygotic transition.
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR.
CDC5L binds to ELAVL1 to inhibit pyroptosis in hepatocellular carcinoma through the Caspase 3/GSDME signaling pathway.
Inhibition of HuR/ELAVL-1 attenuates fibrotic progression in Mdx mice with dilated cardiomyopathy.
MicroCT Enables Simultaneous Longitudinal Tracking of Murine Pancreatic Cancer Progression and Cachexia.
The oncogenic role of SPOCK1 in lung carcinoma by promoting immune evasion and its related mechanisms.
CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis.
The lncRNA ST18-AS1 suppresses pancreatic cancer progression by enhancing ST18 mRNA stability through anchoring FUS in the cytoplasm.
Adipose-specific HuR deletion protects against high-fat diet-induced obesity in mice through upregulating Ucp1 expression.
IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy.
Deciphering the role of ELAVL1: Insights from pan-cancer multiomics analyses with emphasis on nasopharyngeal carcinoma.
CircHOMER1 promotes silica-induced pulmonary fibrosis by binding to HuR and stabilizing NOX4 mRNA.
AP001885.4 promotes the proliferation of esophageal squamous cell carcinoma cells by histone lactylation- and NF-κB (p65)-dependent transcription activation and METTL3-mediated mRNA stability of c-myc.
Blocking SLC7A11 attenuates the proliferation of esophageal squamous cell carcinoma cells.
Long non-coding RNA VCAN-AS1 promotes gastric cancer progression via the HuR/F11R pathway.
RNA binding protein ELAVL1-mediated USP33 stabilizes HIF1A to promote pathological proliferation, migration and angiogenesis of RECs.
Interaction between microRNA-195 and HuR regulates Paneth cell function in the intestinal epithelium by altering SOX9 translation.
RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner.
Hepatocyte-Specific HuR Protects Against Acetaminophen-Induced Liver Injury in Mice.
HuR promotes triglyceride synthesis and intestinal fat absorption.
Colocalization of TDP-43 and stress granules at the early stage of TDP-43 aggregation in amyotrophic lateral sclerosis.
HuR-positive stress granules: Potential targets for age-related osteoporosis.
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress.
DDX6 modulates P-body and stress granule assembly, composition, and docking.
Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes.
Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase.
C-phycocyanin reinforces autophagy to block pulmonary fibrogenesis by inhibiting lncIAPF biogenesis.
Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction.
LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression.
LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m(6) A modification in triple-negative breast cancer.
Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells.
Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin β1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer.
Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.
VIRMA facilitates intrahepatic cholangiocarcinoma progression through epigenetic augmentation of TMED2 and PARD3B mRNA stabilization.
NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R.
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Hsa_circ_0001944 regulates apoptosis by regulating the binding of PARP1 and HuR in leukemia and malignant transformed cells induced by hydroquinone.
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers.
LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis.
RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons.
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential.
Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1.
The RNA-binding protein landscapes differ between mammalian organs and cultured cells.
Long Noncoding RNA ENSG00000254693 Promotes Diabetic Kidney Disease via Interacting with HuR.
HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression.
Danshensu methyl ester enhances autophagy to attenuate pulmonary fibrosis by targeting lncIAPF-HuR complex.
The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.
Knockdown of circHIPK3 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells through activating the autophagy flux.
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus.
CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis.
m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma.
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer.
LINC00467 Promotes Tumor Progression via Regulation of the NF-kb Signal Axis in Bladder Cancer.
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability.
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
Long Noncoding RNA VESTAR Regulates Lymphangiogenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing VEGFC mRNA Stability.
Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis.
Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins.
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
MicroRNA-145 suppresses gastric cancer progression by targeting Hu-antigen R.
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Fast and unbiased purification of RNA-protein complexes after UV cross-linking.
LncRNA MALAT1 affects the migration and invasion of trophoblast cells by regulating FOS expression in early-onset preeclampsia.
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner.
An oncopeptide regulates m(6)A recognition by the m(6)A reader IGF2BP1 and tumorigenesis.
LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction.
Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Zika Virus Subverts Stress Granules To Promote and Restrict Viral Gene Expression.
Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.
Stress granules regulate stress-induced paraspeckle assembly.
LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR-184 in chronic myelogenous leukaemia cells.
Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus.
Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture.
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Dcp1a and GW182 Induce Distinct Cellular Aggregates and Have Different Effects on microRNA Pathway.
E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C.
Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells.
Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy.
A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice.
HuR antagonizes the effect of an intronic pyrimidine-rich sequence in regulating WT1 +/-KTS isoforms.
C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis.
The Structure of the Cyprinid herpesvirus 3 ORF112-Zα·Z-DNA Complex Reveals a Mechanism of Nucleic Acids Recognition Conserved with E3L, a Poxvirus Inhibitor of Interferon Response.
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.
Post-transcriptional up-regulation of PDGF-C by HuR in advanced and stressed breast cancer.
AUF1 is recruited to the stress granules induced by coxsackievirus B3.
Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections.
HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.
Chen J, Wang Z, Liao Y, Ding W
Journal of inflammation research 2026;19:553934
Journal of inflammation research 2026;19:553934
3-Hydroxystearic acid promotes cholesterol efflux and attenuates atherosclerosis via the ALKBH5/PAX-8/ABCA1 pathway.
Zhou QY, Liu W, Zhao ZW, Gong D, Ma XF, Tang CK
Frontiers in immunology 2026;17:1750021
Frontiers in immunology 2026;17:1750021
Regulation of sepsis-associated acute kidney injury by ELAVL1 through USP14/NCOA4-mediated ferroptosis in renal tubular epithelial cells.
Zhu X, Zheng P, Jin H, Zhao Q, Kong K, Zheng L, Huang X, Zheng M
Molecular and cellular biochemistry 2026 May;481(5):2253-2266
Molecular and cellular biochemistry 2026 May;481(5):2253-2266
ELAVL1 Promotes Proliferation and Inhibits Apoptosis of the Marek's Disease Virus (MDV)-Transformed Cell Line MSB1 via the COX-2/PGE2 Pathway.
He L, Zhan DM, Peng H, Gao MR, Chen J, Jia YY, Liao CS, Chen SB, Ding K, Yu ZH
Animals : an open access journal from MDPI 2026 Mar 7;16(5)
Animals : an open access journal from MDPI 2026 Mar 7;16(5)
ELAVL1 modulates periodontal ligament fibroblast pyroptosis in periodontitis through the JAK2/STAT3/NLRP3 axis.
Zhan H, Shi G, Xie Q, Chen Y, Zhang Y
International immunology 2026 Mar 16;
International immunology 2026 Mar 16;
Lactylation of SLC26A3 in the acidic tumor microenvironment promotes malignant progression of colorectal carcinoma.
Chen C, Cai D, Liu X, Zheng Y, Huang X, Chen D, Cai J, Bie Y, Zhou Z, Hu C, Wei Z, Cai K, Li T, Luo S, Liu D, Wu K, Cai Z, Gao F, Wu X, Hu P
Cell death & disease 2026 Jan 30;17(1):164
Cell death & disease 2026 Jan 30;17(1):164
Circular RNA circFNDC3B Modulates M2 Macrophage Activation and Intestinal Inflammation in Crohn's Disease.
Yin J, Liu M, Zhang L, Hu T, Yu Q, Kong R, Liu Z, Pang Z, Chen L, Zhou C, Ye Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71498
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71498
Tet2 deficiency-induced expansion of monocyte-derived macrophages promotes liver fibrosis.
Feng J, Wu B, Li Y, Sun P, Liu Q, Xiao Q, Cai JB, Zheng Y, Chen H, Xu Y, Liu Y, Shi GM, Tan L, Shi YG
The Journal of experimental medicine 2026 Feb 2;223(2)
The Journal of experimental medicine 2026 Feb 2;223(2)
BAP31-ELAVL1-SPINK6 axis induces loss of cell polarity and promotes metastasis in hepatocellular carcinoma.
Zhang X, Wang J, Liang X, Jiang D, Sun Y, Hu C, Hu F, He Y, Sun Y, Zhang J, Ding J, Cai S, Wang Y, Yang S, Yang K
International journal of biological sciences 2025;21(4):1632-1648
International journal of biological sciences 2025;21(4):1632-1648
Kuiyangling Enema Alleviates Ulcerative Colitis Mice by Reducing Levels of Intestinal NETs and Promoting HuR/VDR Signaling.
Zhang D, Zhu Z, He Z, Duan S, Yi Q, Qiu M, Dai X, Su G, Li K, Xu L, Liu D, Wu Y, Gao Y, Li R, Guo S
Journal of inflammation research 2025;18:381-403
Journal of inflammation research 2025;18:381-403
HuR ablation destabilizes Foxp3 mRNA and impairs regulatory T cell function, contributing to an autoimmune phenotype.
Fattahi F, Ellis JS, Vallance L, Bahleda K, Holden J, Socha S, Meier J, Gomez-Rivera F, Atasoy U
Frontiers in immunology 2025;16:1618677
Frontiers in immunology 2025;16:1618677
Tobacco smoking exposure-mediated ELAVL1 regulates bladder cancer cell senescence via autophagy activation.
Pu Q, Gao F, Xiao Y, Wu J, Wang C, Mo X, Zhang Z, Zheng R, Wu D
Toxicology 2025 Sep;516:154193
Toxicology 2025 Sep;516:154193
Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis-Mediated DNA Repair in Osteosarcoma.
Liang Y, Li Z, Tang L, Pan Z, Fei X, Tan C, He A, Yang Q, Cheng D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e02926
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e02926
Mycophenolate mofetil inhibits ferroptosis by boosting autophagy to prevent pulmonary fibrosis.
Liu W, Liu B, Lv C, Li H, Wang Y, Song X, Chen M
Archives of biochemistry and biophysics 2025 Oct;772:110553
Archives of biochemistry and biophysics 2025 Oct;772:110553
HuB serves as the central hub for connecting HuR-related mRNAs with translation machinery in inflammation.
Zhang J, Huang X, Tang Y, Zhong X, Wang J, Wei M, Han X, Ke Y, Ba X
Communications biology 2025 Nov 30;9(1):3
Communications biology 2025 Nov 30;9(1):3
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair.
Wang Y, Tan L, Yang Y, Duan H, Liu C, Zhao J, Zhou Y, Li C, Liu M
Nature communications 2025 Nov 20;16(1):11253
Nature communications 2025 Nov 20;16(1):11253
M2 macrophage-derived exosomes promote cell proliferation, migration and EMT of non-small cell lung cancer by secreting miR-155-5p.
Fang H, Chi X, Wang M, Liu J, Sun M, Zhang J, Zhang W
Molecular and cellular biochemistry 2025 May;480(5):3019-3032
Molecular and cellular biochemistry 2025 May;480(5):3019-3032
LncRNA TUG1 Repressed Angiogenesis by Promoting the Ubiquitination of HuR and Inhibiting Its Nuclear Translocation in Cerebral Ischemic Reperfusion Injury.
Jiang H, Cai Q, He P, Li F, Chen Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2413333
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2413333
Profiling local translatomes and RNA binding proteins of somatosensory neurons reveals specializations of individual axons.
Silagi ES, Nduka E, Pazyra-Murphy MF, Paiz JZ, Bhuiyan SA, Segal RA
bioRxiv : the preprint server for biology 2025 Mar 2;
bioRxiv : the preprint server for biology 2025 Mar 2;
Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer.
Lin Z, Zhong C, Shi M, Long Q, Jing L, Yu Y, Chou J, Chen M, Lan M, Long F
Cell death & disease 2025 Jun 5;16(1):436
Cell death & disease 2025 Jun 5;16(1):436
The RNA-stability-independent role of the RNA m(6)A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance.
Liu T, Yang D, Wei Q, Wang Y, Tian L, Liu X, Yang Y, Luo Q, Xu J, Liu Y, Yang C, Zuo X, Luo F, Luo X, Zhao H, Li L, Xu J, Yu J, Ma S, Yu J, Yi P
Molecular cell 2025 Jun 19;85(12):2320-2336.e9
Molecular cell 2025 Jun 19;85(12):2320-2336.e9
Enhancing mRNA translation efficiency by introducing sequence optimized AU-rich elements in 3' UTR via HuR anchorage.
Ma X, Liu S, Fan B, Jin D, Miao L, Liu L, Du S, Lin J
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102485
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102485
MicroCT enables simultaneous longitudinal tracking of murine pancreatic cancer progression and cachexia.
Pelz KR, Jimenez P, Daniel CJ, Newton SD, Cunningham M, Sears RC, Worth PJ, Brody JR, Zimmers TA
bioRxiv : the preprint server for biology 2025 Jun 1;
bioRxiv : the preprint server for biology 2025 Jun 1;
METTL3 facilitates osteoblast differentiation and bone regeneration via m6A-dependent maturation of pri-miR-324-5p.
Xiao J, Xu Z, Deng Z, Xie J, Qiu Y
Cellular immunology 2025 Jul;413:104974
Cellular immunology 2025 Jul;413:104974
ELAVL1-mediated USP29 mRNA degradation activates TAK1 driving M1 microglial polarization and neural stem cell differentiation dysregulation in spinal cord injury.
Sha C, Pan F, Liu X, Wang Z, Liu G, Huang K
Cell death discovery 2025 Jul 9;11(1):317
Cell death discovery 2025 Jul 9;11(1):317
RNA binding protein HuR regulated by OIP5-AS1 may be involved in maternal transcript degradation during the human maternal-to-zygotic transition.
Liu YN, Li KY, Wei H, Li WX, Zhang YH, Qiu JJ, Zeng F, Yan JB
BMC genomics 2025 Jul 1;26(1):600
BMC genomics 2025 Jul 1;26(1):600
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
Li J, Bai R, Zhou Y, Song X, Li L
PLoS genetics 2025 Jan;21(1):e1011580
PLoS genetics 2025 Jan;21(1):e1011580
Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR.
Yu A, Wang Y, Duan C, Qin J, Liao M, Zhu H, Lei J, Liu J, Yang Z, Yu L, Gui H, Xin J, Tao W, Bao W, Dong Z
Communications biology 2025 Jan 17;8(1):71
Communications biology 2025 Jan 17;8(1):71
CDC5L binds to ELAVL1 to inhibit pyroptosis in hepatocellular carcinoma through the Caspase 3/GSDME signaling pathway.
Liang S, Zhu Z, Tang Y, Zhou S, Xiao M, Gong X, Ye K
International journal of molecular medicine 2025 Dec;56(6)
International journal of molecular medicine 2025 Dec;56(6)
Inhibition of HuR/ELAVL-1 attenuates fibrotic progression in Mdx mice with dilated cardiomyopathy.
Farini A, Molinaro M, Mostosi D, Camera M, Russo M, Leonetti E, Meregalli M, Prandi L, Liaci C, Ghigo A, Hirsch E, Merlo G, Torrente Y
Cellular and molecular life sciences : CMLS 2025 Dec 30;83(1):49
Cellular and molecular life sciences : CMLS 2025 Dec 30;83(1):49
MicroCT Enables Simultaneous Longitudinal Tracking of Murine Pancreatic Cancer Progression and Cachexia.
Pelz KR, Jimenez P, Daniel CJ, Newton SD, Cunningham M, Sears RC, Worth PJ, Brody JR, Zimmers TA
Cancer research communications 2025 Dec 1;5(12):2197-2206
Cancer research communications 2025 Dec 1;5(12):2197-2206
The oncogenic role of SPOCK1 in lung carcinoma by promoting immune evasion and its related mechanisms.
Lv G, Chen J, Wei D, Zhang W, Xie W, Yang S
Cytotechnology 2025 Aug;77(4):138
Cytotechnology 2025 Aug;77(4):138
CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis.
Lu Y, Wu H, Luo Y, Xia W, Sun D, Chen R, Miao Z, Zhang W, Yu Y, Wen A
Inflammation 2025 Aug;48(4):2503-2515
Inflammation 2025 Aug;48(4):2503-2515
The lncRNA ST18-AS1 suppresses pancreatic cancer progression by enhancing ST18 mRNA stability through anchoring FUS in the cytoplasm.
Cheng L, Yu H, Qin Y, Wang R, Su T, Lyu G, Huang Z, Li H, Jin Y, Li Y, Wang G
Oncogene 2025 Aug;44(32):2850-2863
Oncogene 2025 Aug;44(32):2850-2863
Adipose-specific HuR deletion protects against high-fat diet-induced obesity in mice through upregulating Ucp1 expression.
Fan X, Wang Y, Li P, Wang R, Tang T, Qi K
Lipids in health and disease 2025 Aug 25;24(1):264
Lipids in health and disease 2025 Aug 25;24(1):264
IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy.
Zheng MM, Li JY, Guo HJ, Zhang J, Wang LS, Jiang KF, Wu HH, He QJ, Ding L, Yang B
Acta pharmacologica Sinica 2025 Apr;46(4):1058-1067
Acta pharmacologica Sinica 2025 Apr;46(4):1058-1067
Deciphering the role of ELAVL1: Insights from pan-cancer multiomics analyses with emphasis on nasopharyngeal carcinoma.
Xie J, Xie Y, Tan W, Ye Y, Ou X, Zou X, He Z, Wu J, Deng X, Tang H, He L, Li K, Luo P, Bai K, Huang G, Li J
Journal of translational internal medicine 2025 Apr;13(2):138-155
Journal of translational internal medicine 2025 Apr;13(2):138-155
CircHOMER1 promotes silica-induced pulmonary fibrosis by binding to HuR and stabilizing NOX4 mRNA.
Wu Q, Zhang Q, Jin C, Liu X, Yu H
Cellular signalling 2025 Apr;128:111638
Cellular signalling 2025 Apr;128:111638
AP001885.4 promotes the proliferation of esophageal squamous cell carcinoma cells by histone lactylation- and NF-κB (p65)-dependent transcription activation and METTL3-mediated mRNA stability of c-myc.
Fu C, Jiang W, Wang C, Song SJ, Tao H, Zhang XG, Li WT, Jin X, Yu BB, Hao JJ, Sun WJ, Bai J, Shi ZZ
Animal cells and systems 2024;28(1):536-550
Animal cells and systems 2024;28(1):536-550
Blocking SLC7A11 attenuates the proliferation of esophageal squamous cell carcinoma cells.
Li WT, Jin X, Song SJ, Wang C, Fu C, Jiang W, Bai J, Shi ZZ
Animal cells and systems 2024;28(1):237-250
Animal cells and systems 2024;28(1):237-250
Long non-coding RNA VCAN-AS1 promotes gastric cancer progression via the HuR/F11R pathway.
Xu W, Zuo H, Miao X, Zhu J, Tang W, Yuan Z, Gu M, Gu X
American journal of translational research 2024;16(11):6489-6499
American journal of translational research 2024;16(11):6489-6499
RNA binding protein ELAVL1-mediated USP33 stabilizes HIF1A to promote pathological proliferation, migration and angiogenesis of RECs.
Xie J, Jiang J, Wang X, Zuo X, Jia Y
International ophthalmology 2024 Sep 25;44(1):393
International ophthalmology 2024 Sep 25;44(1):393
Interaction between microRNA-195 and HuR regulates Paneth cell function in the intestinal epithelium by altering SOX9 translation.
Kwon MS, Chung HK, Xiao L, Yu TX, Sharma S, Cairns CM, Chen T, Chae S, Turner DJ, Wang JY
American journal of physiology. Cell physiology 2024 Sep 1;327(3):C817-C829
American journal of physiology. Cell physiology 2024 Sep 1;327(3):C817-C829
RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner.
Luo J, Yang C, Xu S, Ji Z, Zhang Y, Bai H, Deng Z, Liang J, Huang Y, Zhi E, Tian R, Li P, Zhao F, Zhou Z, Li Z, Yao C
Communications biology 2024 Oct 21;7(1):1362
Communications biology 2024 Oct 21;7(1):1362
Hepatocyte-Specific HuR Protects Against Acetaminophen-Induced Liver Injury in Mice.
Lu L, Chen J, Jiang H, Li N, Li X, Liu Y, Zong C
Journal of cellular and molecular medicine 2024 Nov;28(22):e70246
Journal of cellular and molecular medicine 2024 Nov;28(22):e70246
HuR promotes triglyceride synthesis and intestinal fat absorption.
Liu C, Lin Y, Wang Y, Lin S, Zhou J, Tang H, Yi X, Ma Z, Xia T, Jiang B, Tian F, Ju Z, Liu B, Gu X, Yang Z, Wang W
Cell reports 2024 May 28;43(5):114238
Cell reports 2024 May 28;43(5):114238
Colocalization of TDP-43 and stress granules at the early stage of TDP-43 aggregation in amyotrophic lateral sclerosis.
Mori F, Yasui H, Miki Y, Kon T, Arai A, Kurotaki H, Tomiyama M, Wakabayashi K
Brain pathology (Zurich, Switzerland) 2024 Mar;34(2):e13215
Brain pathology (Zurich, Switzerland) 2024 Mar;34(2):e13215
HuR-positive stress granules: Potential targets for age-related osteoporosis.
Huai Y, Wang X, Mao W, Wang X, Zhao Y, Chu X, Huang Q, Ru K, Zhang L, Li Y, Chen Z, Qian A
Aging cell 2024 Mar;23(3):e14053
Aging cell 2024 Mar;23(3):e14053
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y
The Journal of cell biology 2024 Mar 4;223(3)
The Journal of cell biology 2024 Mar 4;223(3)
Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress.
Patil M, Singh S, Dubey PK, Tousif S, Umbarkar P, Zhang Q, Lal H, Sewell-Loftin MK, Umeshappa CS, Ghebre YT, Pogwizd S, Zhang J, Krishnamurthy P
JACC. Basic to translational science 2024 Jun;9(6):754-770
JACC. Basic to translational science 2024 Jun;9(6):754-770
DDX6 modulates P-body and stress granule assembly, composition, and docking.
Ripin N, Macedo de Vasconcelos L, Ugay DA, Parker R
The Journal of cell biology 2024 Jun 3;223(6)
The Journal of cell biology 2024 Jun 3;223(6)
Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes.
Zhang X, Das T, Chao TF, Trinh V, Carmen-Orozco RP, Ling JP, Kalab P, Hayes LR
iScience 2024 Jun 21;27(6):110109
iScience 2024 Jun 21;27(6):110109
Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase.
Noble M, Chatterjee A, Sekaran T, Schwarzl T, Hentze MW
RNA (New York, N.Y.) 2024 Jun 17;30(7):839-853
RNA (New York, N.Y.) 2024 Jun 17;30(7):839-853
C-phycocyanin reinforces autophagy to block pulmonary fibrogenesis by inhibiting lncIAPF biogenesis.
Hu W, Wang Y, Yang H, Zhang L, Liu B, Ji Y, Song X, Lv C, Zhang S
Archives of pharmacal research 2024 Jul;47(7):659-674
Archives of pharmacal research 2024 Jul;47(7):659-674
Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction.
Long F, Zhong C, Long Q, Zhu K, Wang J, Yu Y, Xie C, Hu G
Cancer gene therapy 2024 Feb;31(2):237-249
Cancer gene therapy 2024 Feb;31(2):237-249
LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression.
Liu HT, Gao ZX, Li F, Guo XY, Li CL, Zhang H, Zhao RN, Liu Y, Shi DB, Zhu WJ, Gao P
Cell death and differentiation 2024 Feb;31(2):188-202
Cell death and differentiation 2024 Feb;31(2):188-202
LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m(6) A modification in triple-negative breast cancer.
Yu Y, Deng H, Wang W, Xiao S, Zheng R, Lv L, Wang H, Chen J, Zhang B
Clinical and translational medicine 2024 Feb;14(2):e1583
Clinical and translational medicine 2024 Feb;14(2):e1583
Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells.
Ren J, Zhao S, Lai J
Cancer biology & therapy 2024 Dec 31;25(1):2328382
Cancer biology & therapy 2024 Dec 31;25(1):2328382
Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin β1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer.
Liu J, Tang L, Chu W, Wei L
Biochemical genetics 2024 Aug;62(4):2686-2701
Biochemical genetics 2024 Aug;62(4):2686-2701
Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.
Ou N, Wang Y, Xu S, Luo J, Zhang C, Zhang Y, Shi X, Xiong M, Zhao L, Ji Z, Zhang Y, Zhao J, Bai H, Tian R, Li P, Zhi E, Huang Y, Chen W, Wang R, Jin Y, Wang D, Li Z, Chen H, Yao C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Yang Y, Ren J, Zhang J, Shi H, Wang J, Yan Y
Redox biology 2024 Apr;70:103067
Redox biology 2024 Apr;70:103067
Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.
Zhou Y, Ray PS, Zhu J, Stein F, Rettel M, Sekaran T, Sahadevan S, Perez-Perri JI, Roth EK, Myklebost O, Meza-Zepeda LA, von Deimling A, Fu C, Brosig AN, Boye K, Nathrath M, Blattmann C, Lehner B, Hentze MW, Kulozik AE
Nature communications 2024 Apr 1;15(1):2810
Nature communications 2024 Apr 1;15(1):2810
VIRMA facilitates intrahepatic cholangiocarcinoma progression through epigenetic augmentation of TMED2 and PARD3B mRNA stabilization.
Xu H, Lin X, Li Z, He X, Li Y, Qiu L, Lu L, Liu B, Zhan M, He K
Journal of gastroenterology 2023 Sep;58(9):925-944
Journal of gastroenterology 2023 Sep;58(9):925-944
NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R.
Guo C, Ji W, Yang W, Deng Q, Zheng T, Wang Z, Sui W, Zhai C, Yu F, Xi B, Yu X, Xu F, Zhang Q, Zhang W, Kong J, Zhang M, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2303283
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2303283
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N
Nature cancer 2023 Mar;4(3):365-381
Nature cancer 2023 Mar;4(3):365-381
A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.
Wang L, Ji Y, Chen Y, Bai J, Gao P, Feng P
Human molecular genetics 2023 Mar 6;32(6):971-983
Human molecular genetics 2023 Mar 6;32(6):971-983
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Navickas A, Asgharian H, Winkler J, Fish L, Garcia K, Markett D, Dodel M, Culbertson B, Miglani S, Joshi T, Yin K, Nguyen P, Zhang S, Stevers N, Hwang HW, Mardakheh F, Goga A, Goodarzi H
Nature cell biology 2023 Jun;25(6):892-903
Nature cell biology 2023 Jun;25(6):892-903
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Zhang W, Pan X, Xu Y, Guo H, Zheng M, Chen X, Wu H, Luan F, He Q, Ding L, Yang B
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Hsa_circ_0001944 regulates apoptosis by regulating the binding of PARP1 and HuR in leukemia and malignant transformed cells induced by hydroquinone.
Zhong B, Ling X, Meng J, Han Y, Zhang H, Liu Z, Chen J, Zhang H, Pan Z, Liu L
Environmental toxicology 2023 Feb;38(2):381-391
Environmental toxicology 2023 Feb;38(2):381-391
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers.
Zheng S, Wang X, Liu H, Zhao D, Lin Q, Jiang Q, Li L, Hu Y
Cell death and differentiation 2023 Feb;30(2):327-340
Cell death and differentiation 2023 Feb;30(2):327-340
LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis.
Ye D, Liu H, Zhao G, Chen A, Jiang Y, Hu Y, Liu D, Xie N, Liang W, Chen X, Zhang H, Li C, Wang J, Sun D, Chen W, Tan D, Wang Q, Wang H, Yu D, Wu B, Wang M, Cui S, Liu S, Zhang X
Cell death & disease 2023 Feb 27;14(2):165
Cell death & disease 2023 Feb 27;14(2):165
RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons.
Asamitsu S, Yabuki Y, Matsuo K, Kawasaki M, Hirose Y, Kashiwazaki G, Chandran A, Bando T, Wang DO, Sugiyama H, Shioda N
Science advances 2023 Feb 24;9(8):eade2035
Science advances 2023 Feb 24;9(8):eade2035
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503
Nature chemical biology 2023 Dec;19(12):1492-1503
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential.
He J, Lin M, Zhang X, Zhang R, Tian T, Zhou Y, Dong W, Yang Y, Sun X, Dai Y, Xu Y, Zhang Z, Xu M, Lei QY, Xu Y, Lv L
Cell discovery 2023 Aug 8;9(1):84
Cell discovery 2023 Aug 8;9(1):84
Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1.
Tong L, Rao J, Yang C, Xu J, Lu Y, Zhang Y, Cang X, Xie S, Mao J, Jiang P
iScience 2023 Aug 18;26(8):107446
iScience 2023 Aug 18;26(8):107446
The RNA-binding protein landscapes differ between mammalian organs and cultured cells.
Perez-Perri JI, Ferring-Appel D, Huppertz I, Schwarzl T, Sahadevan S, Stein F, Rettel M, Galy B, Hentze MW
Nature communications 2023 Apr 12;14(1):2074
Nature communications 2023 Apr 12;14(1):2074
Long Noncoding RNA ENSG00000254693 Promotes Diabetic Kidney Disease via Interacting with HuR.
Yu Q, Lin J, Ma Q, Li Y, Wang Q, Chen H, Liu Y, Liu B
Journal of diabetes research 2022;2022:8679548
Journal of diabetes research 2022;2022:8679548
HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression.
Cui J, Cao N, Wang G, Wang F, Yang B, Wang J, Lv Y, Chen Y, Li F
Disease markers 2022;2022:5141927
Disease markers 2022;2022:5141927
Danshensu methyl ester enhances autophagy to attenuate pulmonary fibrosis by targeting lncIAPF-HuR complex.
Zhu Q, Wang J, Ji Y, Luan J, Yue D, Liu W, Li H, Zhang J, Qu G, Lv C, Song X
Frontiers in pharmacology 2022;13:1013098
Frontiers in pharmacology 2022;13:1013098
The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.
Duszczyk MM, Wischnewski H, Kazeeva T, Arora R, Loughlin FE, von Schroetter C, Pradère U, Hall J, Ciaudo C, Allain FH
Nature communications 2022 Oct 6;13(1):5892
Nature communications 2022 Oct 6;13(1):5892
Knockdown of circHIPK3 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells through activating the autophagy flux.
Zhuang Z, Jin C, Li X, Han Y, Yang Q, Huang Y, Zheng Y, Li W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22590
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22590
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus.
Burke JM, Ripin N, Ferretti MB, St Clair LA, Worden-Sapper ER, Salgado F, Sawyer SL, Perera R, Lynch KW, Parker R
PLoS pathogens 2022 Nov;18(11):e1010930
PLoS pathogens 2022 Nov;18(11):e1010930
CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.
Song X, Chen B, Liang Y, Li Y, Zhang H, Han D, Wang Y, Ye F, Wang L, Zhao W, Yang Q
Cell death discovery 2022 May 14;8(1):261
Cell death discovery 2022 May 14;8(1):261
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis.
Wang J, Ren P, Zeng Z, Ma L, Li Y, Zhang H, Guo W
Bioengineered 2022 Mar;13(3):7457-7470
Bioengineered 2022 Mar;13(3):7457-7470
m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Liang D, Lin WJ, Ren M, Qiu J, Yang C, Wang X, Li N, Zeng T, Sun K, You L, Yan L, Wang W
Autophagy 2022 Jun;18(6):1318-1337
Autophagy 2022 Jun;18(6):1318-1337
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
Li Y, Miao H, Wei W, Tian J, Chen J
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
Dubey S, Dubey PK, Umeshappa CS, Ghebre YT, Krishnamurthy P
Journal of cellular physiology 2022 Apr;237(4):2169-2182
Journal of cellular physiology 2022 Apr;237(4):2169-2182
Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma.
Jin Y, Wang Z, He D, Zhu Y, Hu X, Gong L, Xiao M, Chen X, Cheng Y, Cao K
Frontiers in immunology 2021;12:637933
Frontiers in immunology 2021;12:637933
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer.
Chen J, Wu Y, Luo X, Jin D, Zhou W, Ju Z, Wang D, Meng Q, Wang H, Fu X, Xu J, Song Z
Theranostics 2021;11(15):7507-7526
Theranostics 2021;11(15):7507-7526
LINC00467 Promotes Tumor Progression via Regulation of the NF-kb Signal Axis in Bladder Cancer.
Xiao J, Gong L, Xiao M, He D, Xiang L, Wang Z, Cheng Y, Deng L, Cao K
Frontiers in oncology 2021;11:652206
Frontiers in oncology 2021;11:652206
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability.
Wu B, Yang C, Fang Y, Ding W, Zhang Y
Environmental toxicology 2021 May;36(5):840-849
Environmental toxicology 2021 May;36(5):840-849
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Xue YC, Ng CS, Mohamud Y, Fung G, Liu H, Bahreyni A, Zhang J, Luo H
Journal of virology 2021 May 24;95(12)
Journal of virology 2021 May 24;95(12)
S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
Guo T, Dai Z, You K, Battaglia-Hsu SF, Feng J, Wang F, Li B, Yang J, Li Z
Cell death & disease 2021 Mar 22;12(4):306
Cell death & disease 2021 Mar 22;12(4):306
Long Noncoding RNA VESTAR Regulates Lymphangiogenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma by Enhancing VEGFC mRNA Stability.
Wang Y, Zhang W, Liu W, Huang L, Wang Y, Li D, Wang G, Zhao Z, Chi X, Xue Y, Song Y, Liu X, Zhan Q
Cancer research 2021 Jun 15;81(12):3187-3199
Cancer research 2021 Jun 15;81(12):3187-3199
Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.
Perez-Perri JI, Noerenberg M, Kamel W, Lenz CE, Mohammed S, Hentze MW, Castello A
Nature protocols 2021 Jan;16(1):27-60
Nature protocols 2021 Jan;16(1):27-60
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
Wang Y, Huang F, Liu M, Zhao Q
Biochemical and biophysical research communications 2021 Jan 1;534:597-603
Biochemical and biophysical research communications 2021 Jan 1;534:597-603
Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis.
Diaz-Garcia S, Ko VI, Vazquez-Sanchez S, Chia R, Arogundade OA, Rodriguez MJ, Traynor BJ, Cleveland D, Ravits J
Acta neuropathologica 2021 Dec;142(6):985-1001
Acta neuropathologica 2021 Dec;142(6):985-1001
Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis.
Liu S, Jiang X, Cui X, Wang J, Liu S, Li H, Yang J, Zhang C, Zhang W
Cell death & disease 2021 Apr 9;12(4):385
Cell death & disease 2021 Apr 9;12(4):385
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132
iScience 2020 May 22;23(5):101132
Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins.
Backlund M, Stein F, Rettel M, Schwarzl T, Perez-Perri JI, Brosig A, Zhou Y, Neu-Yilik G, Hentze MW, Kulozik AE
Nucleic acids research 2020 May 21;48(9):4725-4740
Nucleic acids research 2020 May 21;48(9):4725-4740
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
Cheng J, Gao S, Zhu C, Liu S, Li J, Kang J, Wang Z, Wang T
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
MicroRNA-145 suppresses gastric cancer progression by targeting Hu-antigen R.
Li Q, Tong D, Guo C, Wu F, Li F, Wang X, Jiang Q, Wei Y, Liu L, Ni L, Guo B, Huang C
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C605-C614
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C605-C614
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.
Xie M, Yu T, Jing X, Ma L, Fan Y, Yang F, Ma P, Jiang H, Wu X, Shu Y, Xu T
Molecular cancer 2020 Jun 29;19(1):112
Molecular cancer 2020 Jun 29;19(1):112
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Zhang Z, Zong C, Jiang M, Hu H, Cheng X, Ni J, Yi X, Jiang B, Tian F, Chang MW, Su W, Zhu L, Li J, Xiang X, Miao C, Gorospe M, de Cabo R, Dou Y, Ju Z, Yang J, Jiang C, Yang Z, Wang W
Nature communications 2020 Jun 16;11(1):3067
Nature communications 2020 Jun 16;11(1):3067
Fast and unbiased purification of RNA-protein complexes after UV cross-linking.
Urdaneta EC, Beckmann BM
Methods (San Diego, Calif.) 2020 Jun 1;178:72-82
Methods (San Diego, Calif.) 2020 Jun 1;178:72-82
LncRNA MALAT1 affects the migration and invasion of trophoblast cells by regulating FOS expression in early-onset preeclampsia.
Li Q, Wang T, Huang S, Zuo Q, Jiang Z, Yang N, Sun L
Pregnancy hypertension 2020 Jul;21:50-57
Pregnancy hypertension 2020 Jul;21:50-57
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
Xiao M, Liu J, Xiang L, Zhao K, He D, Zeng Q, Zhang Q, Xie D, Deng M, Zhu Y, Zhang Y, Liu Y, Bo H, Liu X, Chen X, Gong L, Bao Y, Hu Y, Cheng Y, Deng L, Zhu R, Xing X, Zhou M, Xiong W, Zhou Y, Zhou J, Li X, Cao K
Clinical and translational medicine 2020 Dec;10(8):e241
Clinical and translational medicine 2020 Dec;10(8):e241
HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner.
Zhao Q, Li C, Yu M, Sun Y, Wang J, Ma L, Sun X, Lu B
RNA biology 2020 Apr;17(4):500-516
RNA biology 2020 Apr;17(4):500-516
An oncopeptide regulates m(6)A recognition by the m(6)A reader IGF2BP1 and tumorigenesis.
Zhu S, Wang JZ, Chen D, He YT, Meng N, Chen M, Lu RX, Chen XH, Zhang XL, Yan GR
Nature communications 2020 Apr 3;11(1):1685
Nature communications 2020 Apr 3;11(1):1685
LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction.
Hao K, Lei W, Wu H, Wu J, Yang Z, Yan S, Lu XA, Li J, Xia X, Han X, Deng W, Zhong G, Zhao ZA, Hu S
Theranostics 2019;9(24):7282-7297
Theranostics 2019;9(24):7282-7297
Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Urdaneta EC, Vieira-Vieira CH, Hick T, Wessels HH, Figini D, Moschall R, Medenbach J, Ohler U, Granneman S, Selbach M, Beckmann BM
Nature communications 2019 Mar 1;10(1):990
Nature communications 2019 Mar 1;10(1):990
Zika Virus Subverts Stress Granules To Promote and Restrict Viral Gene Expression.
Bonenfant G, Williams N, Netzband R, Schwarz MC, Evans MJ, Pager CT
Journal of virology 2019 Jun 15;93(12)
Journal of virology 2019 Jun 15;93(12)
Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.
Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD
JCI insight 2019 Jun 11;5(14)
JCI insight 2019 Jun 11;5(14)
Stress granules regulate stress-induced paraspeckle assembly.
An H, Tan JT, Shelkovnikova TA
The Journal of cell biology 2019 Dec 2;218(12):4127-4140
The Journal of cell biology 2019 Dec 2;218(12):4127-4140
LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR-184 in chronic myelogenous leukaemia cells.
Zhang F, Ni H, Li X, Liu H, Xi T, Zheng L
FEBS letters 2019 Aug;593(15):1993-2007
FEBS letters 2019 Aug;593(15):1993-2007
Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus.
Azam S, Hou S, Zhu B, Wang W, Hao T, Bu X, Khan M, Lei H
RNA biology 2019 Aug;16(8):1001-1009
RNA biology 2019 Aug;16(8):1001-1009
Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture.
Perez-Perri JI, Rogell B, Schwarzl T, Stein F, Zhou Y, Rettel M, Brosig A, Hentze MW
Nature communications 2018 Oct 23;9(1):4408
Nature communications 2018 Oct 23;9(1):4408
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Wang H, Chen Y, Guo J, Shan T, Deng K, Chen J, Cai L, Zhou H, Zhao Q, Jin S, Xia J
Scientific reports 2018 May 4;8(1):7080
Scientific reports 2018 May 4;8(1):7080
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Dcp1a and GW182 Induce Distinct Cellular Aggregates and Have Different Effects on microRNA Pathway.
Wang X, Chang L, Wang H, Su A, Wu Z
DNA and cell biology 2017 Jul;36(7):565-570
DNA and cell biology 2017 Jul;36(7):565-570
E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C.
Sang XB, Zong ZH, Wang LL, Wu DD, Chen S, Liu BL, Zhao Y
Oncotarget 2017 Feb 28;8(9):14777-14793
Oncotarget 2017 Feb 28;8(9):14777-14793
Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells.
Li B, Li X, Xiong H, Zhou P, Ni Z, Yang T, Zhang Y, Zeng Y, He J, Yang F, Zhang N, Wang Y, Zheng Y, He F
Oncotarget 2017 Aug 1;8(31):51748-51757
Oncotarget 2017 Aug 1;8(31):51748-51757
Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy.
Li L, Chen H, Gao Y, Wang YW, Zhang GQ, Pan SH, Ji L, Kong R, Wang G, Jia YH, Bai XW, Sun B
Molecular cancer therapeutics 2016 Sep;15(9):2232-43
Molecular cancer therapeutics 2016 Sep;15(9):2232-43
A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice.
Qin W, Li X, Xie L, Li S, Liu J, Jia L, Dong X, Ren X, Xiao J, Yang C, Zhou Y, Chen Z
Nucleic acids research 2016 Jul 27;44(13):6423-33
Nucleic acids research 2016 Jul 27;44(13):6423-33
HuR antagonizes the effect of an intronic pyrimidine-rich sequence in regulating WT1 +/-KTS isoforms.
Li H, Hou S, Hao T, Azam S, Liu C, Shi L, Lei H
RNA biology 2015;12(12):1364-71
RNA biology 2015;12(12):1364-71
C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis.
Wang Y, Yue D, Xiao M, Qi C, Chen Y, Sun D, Zhang N, Chen R
Journal of proteome research 2015 Feb 6;14(2):804-13
Journal of proteome research 2015 Feb 6;14(2):804-13
The Structure of the Cyprinid herpesvirus 3 ORF112-Zα·Z-DNA Complex Reveals a Mechanism of Nucleic Acids Recognition Conserved with E3L, a Poxvirus Inhibitor of Interferon Response.
Kuś K, Rakus K, Boutier M, Tsigkri T, Gabriel L, Vanderplasschen A, Athanasiadis A
The Journal of biological chemistry 2015 Dec 25;290(52):30713-25
The Journal of biological chemistry 2015 Dec 25;290(52):30713-25
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.
Zhou J, Yang L, Zhong T, Mueller M, Men Y, Zhang N, Xie J, Giang K, Chung H, Sun X, Lu L, Carmichael GG, Taylor HS, Huang Y
Nature communications 2015 Dec 21;6:10221
Nature communications 2015 Dec 21;6:10221
Post-transcriptional up-regulation of PDGF-C by HuR in advanced and stressed breast cancer.
Luo NA, Qu YQ, Yang GD, Wang T, Li RL, Jia LT, Dong R
International journal of molecular sciences 2014 Nov 6;15(11):20306-20
International journal of molecular sciences 2014 Nov 6;15(11):20306-20
AUF1 is recruited to the stress granules induced by coxsackievirus B3.
Wu S, Lin L, Zhao W, Li X, Wang Y, Si X, Wang T, Wu H, Zhai X, Zhong X, Gao S, Tong L, Xu Z, Zhong Z
Virus research 2014 Nov 4;192:52-61
Virus research 2014 Nov 4;192:52-61
Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections.
Wu S, Wang Y, Lin L, Si X, Wang T, Zhong X, Tong L, Luan Y, Chen Y, Li X, Zhang F, Zhao W, Zhong Z
Virology journal 2014 Nov 20;11:192
Virology journal 2014 Nov 20;11:192
HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.
Zhao W, Zhao J, Hou M, Wang Y, Zhang Y, Zhao X, Zhang C, Guo D
International journal of molecular sciences 2014 Feb 20;15(2):2946-58
International journal of molecular sciences 2014 Feb 20;15(2):2946-58
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 11910-1-AP(HuR antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Ethacrynic acid treated HepG2 cells using 11910-1-AP( HuR Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using ELAVL1 antibody 11910-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
