Antibody data
- Antibody Data
- Antigen structure
- References [81]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [2]
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Validation data
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- Product number
- 11910-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11910-1-AP, RRID:AB_11182183
- Product name
- HuR antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HuR antibody (Cat. #11910-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Blocking SLC7A11 attenuates the proliferation of esophageal squamous cell carcinoma cells.
HuR promotes triglyceride synthesis and intestinal fat absorption.
Colocalization of TDP-43 and stress granules at the early stage of TDP-43 aggregation in amyotrophic lateral sclerosis.
HuR-positive stress granules: Potential targets for age-related osteoporosis.
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
DDX6 modulates P-body and stress granule assembly, composition, and docking.
Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction.
LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression.
LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m(6) A modification in triple-negative breast cancer.
Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells.
Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin β1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer.
Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.
VIRMA facilitates intrahepatic cholangiocarcinoma progression through epigenetic augmentation of TMED2 and PARD3B mRNA stabilization.
NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R.
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Hsa_circ_0001944 regulates apoptosis by regulating the binding of PARP1 and HuR in leukemia and malignant transformed cells induced by hydroquinone.
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers.
LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis.
RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons.
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential.
Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1.
The RNA-binding protein landscapes differ between mammalian organs and cultured cells.
Long Noncoding RNA ENSG00000254693 Promotes Diabetic Kidney Disease via Interacting with HuR.
HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression.
Danshensu methyl ester enhances autophagy to attenuate pulmonary fibrosis by targeting lncIAPF-HuR complex.
The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.
Knockdown of circHIPK3 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells through activating the autophagy flux.
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus.
CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis.
m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma.
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer.
LINC00467 Promotes Tumor Progression via Regulation of the NF-kb Signal Axis in Bladder Cancer.
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability.
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis.
Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins.
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
MicroRNA-145 suppresses gastric cancer progression by targeting Hu-antigen R.
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Fast and unbiased purification of RNA-protein complexes after UV cross-linking.
LncRNA MALAT1 affects the migration and invasion of trophoblast cells by regulating FOS expression in early-onset preeclampsia.
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner.
An oncopeptide regulates m(6)A recognition by the m(6)A reader IGF2BP1 and tumorigenesis.
LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction.
Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Zika Virus Subverts Stress Granules To Promote and Restrict Viral Gene Expression.
Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.
Stress granules regulate stress-induced paraspeckle assembly.
LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR-184 in chronic myelogenous leukaemia cells.
Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus.
Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture.
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Dcp1a and GW182 Induce Distinct Cellular Aggregates and Have Different Effects on microRNA Pathway.
E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C.
Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells.
Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy.
A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice.
HuR antagonizes the effect of an intronic pyrimidine-rich sequence in regulating WT1 +/-KTS isoforms.
C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis.
The Structure of the Cyprinid herpesvirus 3 ORF112-Zα·Z-DNA Complex Reveals a Mechanism of Nucleic Acids Recognition Conserved with E3L, a Poxvirus Inhibitor of Interferon Response.
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.
Post-transcriptional up-regulation of PDGF-C by HuR in advanced and stressed breast cancer.
AUF1 is recruited to the stress granules induced by coxsackievirus B3.
Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections.
HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.
Li WT, Jin X, Song SJ, Wang C, Fu C, Jiang W, Bai J, Shi ZZ
Animal cells and systems 2024;28(1):237-250
Animal cells and systems 2024;28(1):237-250
HuR promotes triglyceride synthesis and intestinal fat absorption.
Liu C, Lin Y, Wang Y, Lin S, Zhou J, Tang H, Yi X, Ma Z, Xia T, Jiang B, Tian F, Ju Z, Liu B, Gu X, Yang Z, Wang W
Cell reports 2024 May 28;43(5):114238
Cell reports 2024 May 28;43(5):114238
Colocalization of TDP-43 and stress granules at the early stage of TDP-43 aggregation in amyotrophic lateral sclerosis.
Mori F, Yasui H, Miki Y, Kon T, Arai A, Kurotaki H, Tomiyama M, Wakabayashi K
Brain pathology (Zurich, Switzerland) 2024 Mar;34(2):e13215
Brain pathology (Zurich, Switzerland) 2024 Mar;34(2):e13215
HuR-positive stress granules: Potential targets for age-related osteoporosis.
Huai Y, Wang X, Mao W, Wang X, Zhao Y, Chu X, Huang Q, Ru K, Zhang L, Li Y, Chen Z, Qian A
Aging cell 2024 Mar;23(3):e14053
Aging cell 2024 Mar;23(3):e14053
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y
The Journal of cell biology 2024 Mar 4;223(3)
The Journal of cell biology 2024 Mar 4;223(3)
DDX6 modulates P-body and stress granule assembly, composition, and docking.
Ripin N, Macedo de Vasconcelos L, Ugay DA, Parker R
The Journal of cell biology 2024 Jun 3;223(6)
The Journal of cell biology 2024 Jun 3;223(6)
Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction.
Long F, Zhong C, Long Q, Zhu K, Wang J, Yu Y, Xie C, Hu G
Cancer gene therapy 2024 Feb;31(2):237-249
Cancer gene therapy 2024 Feb;31(2):237-249
LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression.
Liu HT, Gao ZX, Li F, Guo XY, Li CL, Zhang H, Zhao RN, Liu Y, Shi DB, Zhu WJ, Gao P
Cell death and differentiation 2024 Feb;31(2):188-202
Cell death and differentiation 2024 Feb;31(2):188-202
LRPPRC promotes glycolysis by stabilising LDHA mRNA and its knockdown plus glutamine inhibitor induces synthetic lethality via m(6) A modification in triple-negative breast cancer.
Yu Y, Deng H, Wang W, Xiao S, Zheng R, Lv L, Wang H, Chen J, Zhang B
Clinical and translational medicine 2024 Feb;14(2):e1583
Clinical and translational medicine 2024 Feb;14(2):e1583
Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin-resistant non-small cell lung cancer cells.
Ren J, Zhao S, Lai J
Cancer biology & therapy 2024 Dec 31;25(1):2328382
Cancer biology & therapy 2024 Dec 31;25(1):2328382
Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin β1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer.
Liu J, Tang L, Chu W, Wei L
Biochemical genetics 2024 Aug;62(4):2686-2701
Biochemical genetics 2024 Aug;62(4):2686-2701
Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.
Zhou Y, Ray PS, Zhu J, Stein F, Rettel M, Sekaran T, Sahadevan S, Perez-Perri JI, Roth EK, Myklebost O, Meza-Zepeda LA, von Deimling A, Fu C, Brosig AN, Boye K, Nathrath M, Blattmann C, Lehner B, Hentze MW, Kulozik AE
Nature communications 2024 Apr 1;15(1):2810
Nature communications 2024 Apr 1;15(1):2810
VIRMA facilitates intrahepatic cholangiocarcinoma progression through epigenetic augmentation of TMED2 and PARD3B mRNA stabilization.
Xu H, Lin X, Li Z, He X, Li Y, Qiu L, Lu L, Liu B, Zhan M, He K
Journal of gastroenterology 2023 Sep;58(9):925-944
Journal of gastroenterology 2023 Sep;58(9):925-944
NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R.
Guo C, Ji W, Yang W, Deng Q, Zheng T, Wang Z, Sui W, Zhai C, Yu F, Xi B, Yu X, Xu F, Zhang Q, Zhang W, Kong J, Zhang M, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2303283
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2303283
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N
Nature cancer 2023 Mar;4(3):365-381
Nature cancer 2023 Mar;4(3):365-381
A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.
Wang L, Ji Y, Chen Y, Bai J, Gao P, Feng P
Human molecular genetics 2023 Mar 6;32(6):971-983
Human molecular genetics 2023 Mar 6;32(6):971-983
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Navickas A, Asgharian H, Winkler J, Fish L, Garcia K, Markett D, Dodel M, Culbertson B, Miglani S, Joshi T, Yin K, Nguyen P, Zhang S, Stevers N, Hwang HW, Mardakheh F, Goga A, Goodarzi H
Nature cell biology 2023 Jun;25(6):892-903
Nature cell biology 2023 Jun;25(6):892-903
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Zhang W, Pan X, Xu Y, Guo H, Zheng M, Chen X, Wu H, Luan F, He Q, Ding L, Yang B
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Hsa_circ_0001944 regulates apoptosis by regulating the binding of PARP1 and HuR in leukemia and malignant transformed cells induced by hydroquinone.
Zhong B, Ling X, Meng J, Han Y, Zhang H, Liu Z, Chen J, Zhang H, Pan Z, Liu L
Environmental toxicology 2023 Feb;38(2):381-391
Environmental toxicology 2023 Feb;38(2):381-391
iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers.
Zheng S, Wang X, Liu H, Zhao D, Lin Q, Jiang Q, Li L, Hu Y
Cell death and differentiation 2023 Feb;30(2):327-340
Cell death and differentiation 2023 Feb;30(2):327-340
LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis.
Ye D, Liu H, Zhao G, Chen A, Jiang Y, Hu Y, Liu D, Xie N, Liang W, Chen X, Zhang H, Li C, Wang J, Sun D, Chen W, Tan D, Wang Q, Wang H, Yu D, Wu B, Wang M, Cui S, Liu S, Zhang X
Cell death & disease 2023 Feb 27;14(2):165
Cell death & disease 2023 Feb 27;14(2):165
RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons.
Asamitsu S, Yabuki Y, Matsuo K, Kawasaki M, Hirose Y, Kashiwazaki G, Chandran A, Bando T, Wang DO, Sugiyama H, Shioda N
Science advances 2023 Feb 24;9(8):eade2035
Science advances 2023 Feb 24;9(8):eade2035
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503
Nature chemical biology 2023 Dec;19(12):1492-1503
TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential.
He J, Lin M, Zhang X, Zhang R, Tian T, Zhou Y, Dong W, Yang Y, Sun X, Dai Y, Xu Y, Zhang Z, Xu M, Lei QY, Xu Y, Lv L
Cell discovery 2023 Aug 8;9(1):84
Cell discovery 2023 Aug 8;9(1):84
Mutational burden of XPNPEP3 leads to defects in mitochondrial complex I and cilia in NPHPL1.
Tong L, Rao J, Yang C, Xu J, Lu Y, Zhang Y, Cang X, Xie S, Mao J, Jiang P
iScience 2023 Aug 18;26(8):107446
iScience 2023 Aug 18;26(8):107446
The RNA-binding protein landscapes differ between mammalian organs and cultured cells.
Perez-Perri JI, Ferring-Appel D, Huppertz I, Schwarzl T, Sahadevan S, Stein F, Rettel M, Galy B, Hentze MW
Nature communications 2023 Apr 12;14(1):2074
Nature communications 2023 Apr 12;14(1):2074
Long Noncoding RNA ENSG00000254693 Promotes Diabetic Kidney Disease via Interacting with HuR.
Yu Q, Lin J, Ma Q, Li Y, Wang Q, Chen H, Liu Y, Liu B
Journal of diabetes research 2022;2022:8679548
Journal of diabetes research 2022;2022:8679548
HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression.
Cui J, Cao N, Wang G, Wang F, Yang B, Wang J, Lv Y, Chen Y, Li F
Disease markers 2022;2022:5141927
Disease markers 2022;2022:5141927
Danshensu methyl ester enhances autophagy to attenuate pulmonary fibrosis by targeting lncIAPF-HuR complex.
Zhu Q, Wang J, Ji Y, Luan J, Yue D, Liu W, Li H, Zhang J, Qu G, Lv C, Song X
Frontiers in pharmacology 2022;13:1013098
Frontiers in pharmacology 2022;13:1013098
The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.
Duszczyk MM, Wischnewski H, Kazeeva T, Arora R, Loughlin FE, von Schroetter C, Pradère U, Hall J, Ciaudo C, Allain FH
Nature communications 2022 Oct 6;13(1):5892
Nature communications 2022 Oct 6;13(1):5892
Knockdown of circHIPK3 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells through activating the autophagy flux.
Zhuang Z, Jin C, Li X, Han Y, Yang Q, Huang Y, Zheng Y, Li W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22590
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22590
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus.
Burke JM, Ripin N, Ferretti MB, St Clair LA, Worden-Sapper ER, Salgado F, Sawyer SL, Perera R, Lynch KW, Parker R
PLoS pathogens 2022 Nov;18(11):e1010930
PLoS pathogens 2022 Nov;18(11):e1010930
CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.
Song X, Chen B, Liang Y, Li Y, Zhang H, Han D, Wang Y, Ye F, Wang L, Zhao W, Yang Q
Cell death discovery 2022 May 14;8(1):261
Cell death discovery 2022 May 14;8(1):261
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis.
Wang J, Ren P, Zeng Z, Ma L, Li Y, Zhang H, Guo W
Bioengineered 2022 Mar;13(3):7457-7470
Bioengineered 2022 Mar;13(3):7457-7470
m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Liang D, Lin WJ, Ren M, Qiu J, Yang C, Wang X, Li N, Zeng T, Sun K, You L, Yan L, Wang W
Autophagy 2022 Jun;18(6):1318-1337
Autophagy 2022 Jun;18(6):1318-1337
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
Li Y, Miao H, Wei W, Tian J, Chen J
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
Dubey S, Dubey PK, Umeshappa CS, Ghebre YT, Krishnamurthy P
Journal of cellular physiology 2022 Apr;237(4):2169-2182
Journal of cellular physiology 2022 Apr;237(4):2169-2182
Analysis of m6A-Related Signatures in the Tumor Immune Microenvironment and Identification of Clinical Prognostic Regulators in Adrenocortical Carcinoma.
Jin Y, Wang Z, He D, Zhu Y, Hu X, Gong L, Xiao M, Chen X, Cheng Y, Cao K
Frontiers in immunology 2021;12:637933
Frontiers in immunology 2021;12:637933
Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer.
Chen J, Wu Y, Luo X, Jin D, Zhou W, Ju Z, Wang D, Meng Q, Wang H, Fu X, Xu J, Song Z
Theranostics 2021;11(15):7507-7526
Theranostics 2021;11(15):7507-7526
LINC00467 Promotes Tumor Progression via Regulation of the NF-kb Signal Axis in Bladder Cancer.
Xiao J, Gong L, Xiao M, He D, Xiang L, Wang Z, Cheng Y, Deng L, Cao K
Frontiers in oncology 2021;11:652206
Frontiers in oncology 2021;11:652206
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability.
Wu B, Yang C, Fang Y, Ding W, Zhang Y
Environmental toxicology 2021 May;36(5):840-849
Environmental toxicology 2021 May;36(5):840-849
FUS/TLS Suppresses Enterovirus Replication and Promotes Antiviral Innate Immune Responses.
Xue YC, Ng CS, Mohamud Y, Fung G, Liu H, Bahreyni A, Zhang J, Luo H
Journal of virology 2021 May 24;95(12)
Journal of virology 2021 May 24;95(12)
S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
Guo T, Dai Z, You K, Battaglia-Hsu SF, Feng J, Wang F, Li B, Yang J, Li Z
Cell death & disease 2021 Mar 22;12(4):306
Cell death & disease 2021 Mar 22;12(4):306
Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.
Perez-Perri JI, Noerenberg M, Kamel W, Lenz CE, Mohammed S, Hentze MW, Castello A
Nature protocols 2021 Jan;16(1):27-60
Nature protocols 2021 Jan;16(1):27-60
UBE2C mRNA expression controlled by miR-300 and HuR determines its oncogenic role in gastric cancer.
Wang Y, Huang F, Liu M, Zhao Q
Biochemical and biophysical research communications 2021 Jan 1;534:597-603
Biochemical and biophysical research communications 2021 Jan 1;534:597-603
Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis.
Diaz-Garcia S, Ko VI, Vazquez-Sanchez S, Chia R, Arogundade OA, Rodriguez MJ, Traynor BJ, Cleveland D, Ravits J
Acta neuropathologica 2021 Dec;142(6):985-1001
Acta neuropathologica 2021 Dec;142(6):985-1001
Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis.
Liu S, Jiang X, Cui X, Wang J, Liu S, Li H, Yang J, Zhang C, Zhang W
Cell death & disease 2021 Apr 9;12(4):385
Cell death & disease 2021 Apr 9;12(4):385
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Valdez-Sinon AN, Lai A, Shi L, Lancaster CL, Gokhale A, Faundez V, Bassell GJ
iScience 2020 May 22;23(5):101132
iScience 2020 May 22;23(5):101132
Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins.
Backlund M, Stein F, Rettel M, Schwarzl T, Perez-Perri JI, Brosig A, Zhou Y, Neu-Yilik G, Hentze MW, Kulozik AE
Nucleic acids research 2020 May 21;48(9):4725-4740
Nucleic acids research 2020 May 21;48(9):4725-4740
Typical Stress Granule Proteins Interact with the 3' Untranslated Region of Enterovirus D68 To Inhibit Viral Replication.
Cheng J, Gao S, Zhu C, Liu S, Li J, Kang J, Wang Z, Wang T
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
MicroRNA-145 suppresses gastric cancer progression by targeting Hu-antigen R.
Li Q, Tong D, Guo C, Wu F, Li F, Wang X, Jiang Q, Wei Y, Liu L, Ni L, Guo B, Huang C
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C605-C614
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C605-C614
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.
Xie M, Yu T, Jing X, Ma L, Fan Y, Yang F, Ma P, Jiang H, Wu X, Shu Y, Xu T
Molecular cancer 2020 Jun 29;19(1):112
Molecular cancer 2020 Jun 29;19(1):112
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Zhang Z, Zong C, Jiang M, Hu H, Cheng X, Ni J, Yi X, Jiang B, Tian F, Chang MW, Su W, Zhu L, Li J, Xiang X, Miao C, Gorospe M, de Cabo R, Dou Y, Ju Z, Yang J, Jiang C, Yang Z, Wang W
Nature communications 2020 Jun 16;11(1):3067
Nature communications 2020 Jun 16;11(1):3067
Fast and unbiased purification of RNA-protein complexes after UV cross-linking.
Urdaneta EC, Beckmann BM
Methods (San Diego, Calif.) 2020 Jun 1;178:72-82
Methods (San Diego, Calif.) 2020 Jun 1;178:72-82
LncRNA MALAT1 affects the migration and invasion of trophoblast cells by regulating FOS expression in early-onset preeclampsia.
Li Q, Wang T, Huang S, Zuo Q, Jiang Z, Yang N, Sun L
Pregnancy hypertension 2020 Jul;21:50-57
Pregnancy hypertension 2020 Jul;21:50-57
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
Xiao M, Liu J, Xiang L, Zhao K, He D, Zeng Q, Zhang Q, Xie D, Deng M, Zhu Y, Zhang Y, Liu Y, Bo H, Liu X, Chen X, Gong L, Bao Y, Hu Y, Cheng Y, Deng L, Zhu R, Xing X, Zhou M, Xiong W, Zhou Y, Zhou J, Li X, Cao K
Clinical and translational medicine 2020 Dec;10(8):e241
Clinical and translational medicine 2020 Dec;10(8):e241
HuR stabilizes HTT mRNA via interacting with its exon 11 in a mutant HTT-dependent manner.
Zhao Q, Li C, Yu M, Sun Y, Wang J, Ma L, Sun X, Lu B
RNA biology 2020 Apr;17(4):500-516
RNA biology 2020 Apr;17(4):500-516
An oncopeptide regulates m(6)A recognition by the m(6)A reader IGF2BP1 and tumorigenesis.
Zhu S, Wang JZ, Chen D, He YT, Meng N, Chen M, Lu RX, Chen XH, Zhang XL, Yan GR
Nature communications 2020 Apr 3;11(1):1685
Nature communications 2020 Apr 3;11(1):1685
LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction.
Hao K, Lei W, Wu H, Wu J, Yang Z, Yan S, Lu XA, Li J, Xia X, Han X, Deng W, Zhong G, Zhao ZA, Hu S
Theranostics 2019;9(24):7282-7297
Theranostics 2019;9(24):7282-7297
Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.
Urdaneta EC, Vieira-Vieira CH, Hick T, Wessels HH, Figini D, Moschall R, Medenbach J, Ohler U, Granneman S, Selbach M, Beckmann BM
Nature communications 2019 Mar 1;10(1):990
Nature communications 2019 Mar 1;10(1):990
Zika Virus Subverts Stress Granules To Promote and Restrict Viral Gene Expression.
Bonenfant G, Williams N, Netzband R, Schwarz MC, Evans MJ, Pager CT
Journal of virology 2019 Jun 15;93(12)
Journal of virology 2019 Jun 15;93(12)
Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.
Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD
JCI insight 2019 Jun 11;5(14)
JCI insight 2019 Jun 11;5(14)
Stress granules regulate stress-induced paraspeckle assembly.
An H, Tan JT, Shelkovnikova TA
The Journal of cell biology 2019 Dec 2;218(12):4127-4140
The Journal of cell biology 2019 Dec 2;218(12):4127-4140
LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR-184 in chronic myelogenous leukaemia cells.
Zhang F, Ni H, Li X, Liu H, Xi T, Zheng L
FEBS letters 2019 Aug;593(15):1993-2007
FEBS letters 2019 Aug;593(15):1993-2007
Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus.
Azam S, Hou S, Zhu B, Wang W, Hao T, Bu X, Khan M, Lei H
RNA biology 2019 Aug;16(8):1001-1009
RNA biology 2019 Aug;16(8):1001-1009
Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture.
Perez-Perri JI, Rogell B, Schwarzl T, Stein F, Zhou Y, Rettel M, Brosig A, Hentze MW
Nature communications 2018 Oct 23;9(1):4408
Nature communications 2018 Oct 23;9(1):4408
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Wang H, Chen Y, Guo J, Shan T, Deng K, Chen J, Cai L, Zhou H, Zhao Q, Jin S, Xia J
Scientific reports 2018 May 4;8(1):7080
Scientific reports 2018 May 4;8(1):7080
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Dcp1a and GW182 Induce Distinct Cellular Aggregates and Have Different Effects on microRNA Pathway.
Wang X, Chang L, Wang H, Su A, Wu Z
DNA and cell biology 2017 Jul;36(7):565-570
DNA and cell biology 2017 Jul;36(7):565-570
E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C.
Sang XB, Zong ZH, Wang LL, Wu DD, Chen S, Liu BL, Zhao Y
Oncotarget 2017 Feb 28;8(9):14777-14793
Oncotarget 2017 Feb 28;8(9):14777-14793
Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells.
Li B, Li X, Xiong H, Zhou P, Ni Z, Yang T, Zhang Y, Zeng Y, He J, Yang F, Zhang N, Wang Y, Zheng Y, He F
Oncotarget 2017 Aug 1;8(31):51748-51757
Oncotarget 2017 Aug 1;8(31):51748-51757
Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy.
Li L, Chen H, Gao Y, Wang YW, Zhang GQ, Pan SH, Ji L, Kong R, Wang G, Jia YH, Bai XW, Sun B
Molecular cancer therapeutics 2016 Sep;15(9):2232-43
Molecular cancer therapeutics 2016 Sep;15(9):2232-43
A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice.
Qin W, Li X, Xie L, Li S, Liu J, Jia L, Dong X, Ren X, Xiao J, Yang C, Zhou Y, Chen Z
Nucleic acids research 2016 Jul 27;44(13):6423-33
Nucleic acids research 2016 Jul 27;44(13):6423-33
HuR antagonizes the effect of an intronic pyrimidine-rich sequence in regulating WT1 +/-KTS isoforms.
Li H, Hou S, Hao T, Azam S, Liu C, Shi L, Lei H
RNA biology 2015;12(12):1364-71
RNA biology 2015;12(12):1364-71
C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis.
Wang Y, Yue D, Xiao M, Qi C, Chen Y, Sun D, Zhang N, Chen R
Journal of proteome research 2015 Feb 6;14(2):804-13
Journal of proteome research 2015 Feb 6;14(2):804-13
The Structure of the Cyprinid herpesvirus 3 ORF112-Zα·Z-DNA Complex Reveals a Mechanism of Nucleic Acids Recognition Conserved with E3L, a Poxvirus Inhibitor of Interferon Response.
Kuś K, Rakus K, Boutier M, Tsigkri T, Gabriel L, Vanderplasschen A, Athanasiadis A
The Journal of biological chemistry 2015 Dec 25;290(52):30713-25
The Journal of biological chemistry 2015 Dec 25;290(52):30713-25
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.
Zhou J, Yang L, Zhong T, Mueller M, Men Y, Zhang N, Xie J, Giang K, Chung H, Sun X, Lu L, Carmichael GG, Taylor HS, Huang Y
Nature communications 2015 Dec 21;6:10221
Nature communications 2015 Dec 21;6:10221
Post-transcriptional up-regulation of PDGF-C by HuR in advanced and stressed breast cancer.
Luo NA, Qu YQ, Yang GD, Wang T, Li RL, Jia LT, Dong R
International journal of molecular sciences 2014 Nov 6;15(11):20306-20
International journal of molecular sciences 2014 Nov 6;15(11):20306-20
AUF1 is recruited to the stress granules induced by coxsackievirus B3.
Wu S, Lin L, Zhao W, Li X, Wang Y, Si X, Wang T, Wu H, Zhai X, Zhong X, Gao S, Tong L, Xu Z, Zhong Z
Virus research 2014 Nov 4;192:52-61
Virus research 2014 Nov 4;192:52-61
Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections.
Wu S, Wang Y, Lin L, Si X, Wang T, Zhong X, Tong L, Luan Y, Chen Y, Li X, Zhang F, Zhao W, Zhong Z
Virology journal 2014 Nov 20;11:192
Virology journal 2014 Nov 20;11:192
HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.
Zhao W, Zhao J, Hou M, Wang Y, Zhang Y, Zhao X, Zhang C, Guo D
International journal of molecular sciences 2014 Feb 20;15(2):2946-58
International journal of molecular sciences 2014 Feb 20;15(2):2946-58
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 11910-1-AP(HuR antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Ethacrynic acid treated HepG2 cells using 11910-1-AP( HuR Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using ELAVL1 antibody 11910-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line