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- Antibody Data
- Antigen structure
- References [17]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- 21738-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21738-1-AP, RRID:AB_10733888
- Product name
- Integrin Beta 4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Integrin Beta 4 antibody (Cat. #21738-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts.
Integrin β4 Regulates Cell Migration of Lung Adenocarcinoma Through FAK Signaling.
Inhibition of the SLC35B2-TPST2 Axis of Tyrosine Sulfation Attenuates the Growth and Metastasis of Pancreatic Ductal Adenocarcinom.
Identification and Validation of Anoikis-Related Signatures for Predicting Prognosis in Lung Adenocarcinoma with Machine Learning.
A Systemic and Integrated Analysis of p63-Driven Regulatory Networks in Mouse Oral Squamous Cell Carcinoma.
Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma.
Gelatin-grafted tubular asymmetric scaffolds promote ureteral regeneration via activation of the integrin/Erk signaling pathway.
Single-Cell RNA-Seq Reveals Heterogeneity of Cell Communications between Schwann Cells and Fibroblasts within Vestibular Schwannoma Microenvironment.
Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.
METTL14-mediated N(6)-methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma.
Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation.
FAM83A exerts tumor‑suppressive roles in cervical cancer by regulating integrins.
Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traits.
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.
Integrin β4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma.
Deng Z, Yu L, Kuang Y, Zhou Z, Li X
International journal of nanomedicine 2024;19:2469-2485
International journal of nanomedicine 2024;19:2469-2485
Integrin β4 Regulates Cell Migration of Lung Adenocarcinoma Through FAK Signaling.
Zhang S, Liu C, Liu D, Ning X, Li H, Zhang X, Lu Y, Zhang P, Chen S, Cai Z
Molecular biotechnology 2024 Feb 8;
Molecular biotechnology 2024 Feb 8;
Inhibition of the SLC35B2-TPST2 Axis of Tyrosine Sulfation Attenuates the Growth and Metastasis of Pancreatic Ductal Adenocarcinom.
Cai X, Li S, Zeng X, Xu M, Wang Z, Singhi AD, Tang D, Li S, Yates NA, Yang D, Xie W
Cellular and molecular gastroenterology and hepatology 2023;16(3):473-495
Cellular and molecular gastroenterology and hepatology 2023;16(3):473-495
Identification and Validation of Anoikis-Related Signatures for Predicting Prognosis in Lung Adenocarcinoma with Machine Learning.
Wang Q, Sun N, Zhang M
International journal of general medicine 2023;16:1833-1844
International journal of general medicine 2023;16:1833-1844
A Systemic and Integrated Analysis of p63-Driven Regulatory Networks in Mouse Oral Squamous Cell Carcinoma.
Glathar AR, Oyelakin A, Nayak KB, Sosa J, Romano RA, Sinha S
Cancers 2023 Jan 10;15(2)
Cancers 2023 Jan 10;15(2)
Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.
Chen C, Chen J, Wang Y, Fang L, Guo C, Sang T, Peng H, Zhao Q, Chen S, Lin X, Wang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154626
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154626
p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma.
Glathar AR, Oyelakin A, Gluck C, Bard J, Sinha S
Frontiers in oncology 2022;12:879054
Frontiers in oncology 2022;12:879054
Gelatin-grafted tubular asymmetric scaffolds promote ureteral regeneration via activation of the integrin/Erk signaling pathway.
Song B, Fang L, Mao X, Ye X, Yan Z, Ma Q, Shi Z, Hu Y, Zhu Y, Cheng Y
Frontiers in bioengineering and biotechnology 2022;10:1092543
Frontiers in bioengineering and biotechnology 2022;10:1092543
Single-Cell RNA-Seq Reveals Heterogeneity of Cell Communications between Schwann Cells and Fibroblasts within Vestibular Schwannoma Microenvironment.
Xu M, Wang S, Jiang Y, Wang J, Xiong Y, Dong W, Yao Q, Xing Y, Liu F, Chen Z, Yu D
The American journal of pathology 2022 Sep;192(9):1230-1249
The American journal of pathology 2022 Sep;192(9):1230-1249
Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.
Liu H, Liu J, Long C, Chen L, Zhan W, Xiao W, Gong X, Liu M, Tian XL, Chen S
International journal of molecular sciences 2022 Oct 20;23(20)
International journal of molecular sciences 2022 Oct 20;23(20)
METTL14-mediated N(6)-methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma.
Liu Z, Sun T, Piao C, Zhang Z, Kong C
Cell communication and signaling : CCS 2022 Mar 19;20(1):36
Cell communication and signaling : CCS 2022 Mar 19;20(1):36
Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation.
Ning J, Cui X, Li N, Li N, Zhao B, Miao J, Lin Z
Cell adhesion & migration 2022 Dec;16(1):107-114
Cell adhesion & migration 2022 Dec;16(1):107-114
FAM83A exerts tumor‑suppressive roles in cervical cancer by regulating integrins.
Xu J, Lu W
International journal of oncology 2020 Aug;57(2):509-521
International journal of oncology 2020 Aug;57(2):509-521
Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traits.
Ma B, Zhang L, Zou Y, He R, Wu Q, Han C, Zhang B
Journal of experimental & clinical cancer research : CR 2019 Jan 18;38(1):23
Journal of experimental & clinical cancer research : CR 2019 Jan 18;38(1):23
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Li Y, Chen Y, Qiu C, Ma X, Lei K, Cai G, Liang X, Liu J
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.
Wang S, Li J, Xie J, Liu F, Duan Y, Wu Y, Huang S, He X, Wang Z, Wu X
Oncogene 2018 Jul;37(30):4164-4180
Oncogene 2018 Jul;37(30):4164-4180
Integrin β4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma.
Li XL, Liu L, Li DD, He YP, Guo LH, Sun LP, Liu LN, Xu HX, Zhang XP
Scientific reports 2017 Jan 13;7:40464
Scientific reports 2017 Jan 13;7:40464
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 21738-1-AP(ITGB4 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 21738-1-AP(ITGB4 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 21738-1-AP(ITGB4 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Integrin beta-4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Integrin beta-4. This antibody recognizes human,mouse,rat antigen. The Integrin beta-4 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
