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- Antibody Data
- Antigen structure
- References [102]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 17509-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17509-1-AP, RRID:AB_10596914
- Product name
- IRS1 antibody
- Antibody type
- Polyclonal
- Description
- IRS1 antibody (Cat. #17509-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TAT-PBX1 Reverses Hyperglycemia Through β-Cell Regeneration and Functional Restoration in an STZ-Induced Diabetic Model.
Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.
Structural characterization and hypoglycemic mechanisms of a Hericium coralloides heteropolysaccharide (HCP-2b) via gut microbiota modulation and PI3K/Akt signaling.
Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.
Lacticaseibacillus rhamnosus HF01 postbiotics reprogram gut microbial tryptophan metabolism to coordinate enterohepatic barrier-insulin signaling axis.
Insights Into the Mechanism of Action for Qingzhi Decoction for the Treatment of Non-Alcoholic Fatty Liver Disease via Regulation of the IRS/PI3K/Akt Signaling Pathway and the NRLP3 Inflammasome.
Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma.
L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling.
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.
Timing of glucose intake drives distinct hepatic outcomes: Divergent glucose and lipid metabolism.
Helicobacter pylori infection impairs glucose homeostasis through gut microbiota dysbiosis.
Quercetin's regulation of glucose and lipid metabolism in gestational diabetes mellitus: role of the PCSK9/LDLR axis.
Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism.
Metabolites from the Dendrobium Endophyte Pseudomonas protegens CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway.
Deubiquitinating Enzyme USP2 Alleviates Muscle Atrophy by Stabilizing PPAR-γ.
Aerobic exercise improves energy and glucose homeostasis through hypothalamic Mitofusion 2-rescued endoplasmic reticulum stress in diet-induced obese mice.
IL-37 inhibited inflammation to improve gestational diabetes mellitus through the GSK3/NF-κB pathway.
Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway.
Comparison of chemical composition between imitation wild and transplanted Astragali Radix and their therapeutic effects on heart failure.
Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure.
A novel covalent inhibitor alleviates type 2 diabetes mellitus by restraining GSK-3β.
p53 Modulates the Gut-Liver Axis via PI3K/AKT/Wnt Signaling Pathways in Type 2 Diabetes.
Degraded Polysaccharides from Noni (Morinda citrifolia L.) juice Mitigate Glucose Metabolism Disorders by Regulating PI3K/AKT-Nrf2-GSK3β Signaling Pathways in HepG2 Cells.
Electroacupuncture alleviates insulin resistance and impacts the hypothalamic IRS-1/PI3K/AKT pathway and miRNA-29a-3p in a rat model of type 2 diabetes.
Lycium barbarum polysaccharide mitigates high-fat-diet-induced skeletal muscle atrophy by promoting AMPK/PINK1/Parkin-mediated mitophagy.
Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction.
Mechanistic evaluation of Jiu Wei Qing Zhi Gao in non-alcoholic fatty liver disease: insights from network Pharmacology and experimental validation.
Network Pharmacology-Based Strategy to Explore the Effect and Mechanism of Zhizhu Granule Improving Glucose-Lipid Metabolism in Rats with Metabolic Syndrome.
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts.
HADHA promotes esophageal cancer progression by activating mTOR signaling and the SP1/MDM2 axis.
α-Klotho prevents diabetic retinopathy by reversing the senescence of macrophages.
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
Procyanidin B1 and p-coumaric acid from whole highland barley ameliorated HFD-induced impaired glucose tolerance via small intestinal barrier and hepatic glucose metabolism.
Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance.
FGF19 Promotes the Proliferation and Insulin Secretion from Human Pancreatic β Cells Via the IRS1/GLUT4 Pathway.
Augmentation of scleral glycolysis promotes myopia through histone lactylation.
Kallistatin Improves High-Fat-Induced Insulin Resistance via Epididymal Adipose Tissue-Derived Exosomes.
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes.
m6A-Mediated IRS1 Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling.
Inhibiting TRIM8 alleviates adipocyte inflammation and insulin resistance by regulating the DUSP14/MAPKs pathway.
Aerobic exercise attenuates high-fat diet-induced glycometabolism impairments in skeletal muscle of rat: role of EGR-1/PTP1B signaling pathway.
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
Puerarin Attenuates Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress and Suppresses Inflammation by Modulating the JNK and IKKβ/NF-κB Pathways in Epididymal White Adipose Tissue of Mice on a High-Fat Diet.
Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice.
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer's Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway.
Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo.
Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus.
Visceral adipose tissue-directed human kallistatin gene therapy improves adipose tissue remodeling and metabolic health in obese mice.
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis.
Single-cell multi-omics profiling reveals key regulatory mechanisms that poise germinal vesicle oocytes for maturation in pigs.
Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice.
Overexpression of Insulin Receptor Substrate 1 (IRS1) Relates to Poor Prognosis and Promotes Proliferation, Stemness, Migration, and Oxidative Stress Resistance in Cholangiocarcinoma.
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways.
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
Effect of crude polysaccharide from seaweed, Dictyopteris divaricata (CDDP) on gut microbiota restoration and anti-diabetic activity in streptozotocin (STZ)-induced T1DM mice.
Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice.
RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study.
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway.
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
Ginsenoside compound K inhibits obesity-induced insulin resistance by regulation of macrophage recruitment and polarization via activating PPARγ.
Spatiotemporal regulation of insulin signaling by liquid-liquid phase separation.
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Insulin receptor substrate 1(IRS1) is related with lymph node metastases and prognosis in esophageal squamous cell carcinoma.
Fermented noni (Morinda citrifolia L.) fruit juice improved oxidative stress and insulin resistance under the synergistic effect of Nrf2/ARE pathway and gut flora in db/db mice and HepG2 cells.
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Pentadecanoic acid promotes basal and insulin-stimulated glucose uptake in C2C12 myotubes.
The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats.
DPHC From Alpinia officinarum Ameliorates Oxidative Stress and Insulin Resistance via Activation of Nrf2/ARE Pathway in db/db Mice and High Glucose-Treated HepG2 Cells.
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats.
KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis.
Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2.
Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
A maternal high-fat/low-fiber diet impairs glucose tolerance and induces the formation of glycolytic muscle fibers in neonatal offspring.
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling.
miR-203 inhibits cell proliferation and ERK pathway in prostate cancer by targeting IRS-1.
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring.
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Suppression of miR-143 contributes to overexpression of IL-6, HIF-1α and NF-κB p65 in Cr(VI)-induced human exposure and tumor growth.
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice.
miR-146b Inhibits Glucose Consumption by Targeting IRS1 Gene in Porcine Primary Adipocytes.
NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Meng X, Zhao Z, Zhang X, Guo R, Yang S, Mao S, Zong Z, Liu J
Pharmaceuticals (Basel, Switzerland) 2026 Jan 1;19(1)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 1;19(1)
Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.
Tang J, Ye W, He L, Dan Z, Chang L, You Z, Jiang Y, Tang G, Deng L, Li C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e12424
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e12424
Structural characterization and hypoglycemic mechanisms of a Hericium coralloides heteropolysaccharide (HCP-2b) via gut microbiota modulation and PI3K/Akt signaling.
Wang M, Fu H, Lv G, Zhao R, Cai W, Pi X, Zhang Z
Carbohydrate polymers 2026 Apr 15;378:124879
Carbohydrate polymers 2026 Apr 15;378:124879
Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.
Gao G, Chen A, Yan Y, Sagor MIH, Lin W, Lin H, Lian G, Xie L, Luo L
Frontiers in cardiovascular medicine 2025;12:1543319
Frontiers in cardiovascular medicine 2025;12:1543319
Lacticaseibacillus rhamnosus HF01 postbiotics reprogram gut microbial tryptophan metabolism to coordinate enterohepatic barrier-insulin signaling axis.
Sun Y, Liu X, Zhao L, Li D, Guan K, Ma Y, Wang R, Li Q
Current research in food science 2025;11:101111
Current research in food science 2025;11:101111
Insights Into the Mechanism of Action for Qingzhi Decoction for the Treatment of Non-Alcoholic Fatty Liver Disease via Regulation of the IRS/PI3K/Akt Signaling Pathway and the NRLP3 Inflammasome.
Yan J, Hou Q, Liu J, Li W
Biomedical chromatography : BMC 2025 Sep;39(9):e70156
Biomedical chromatography : BMC 2025 Sep;39(9):e70156
Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma.
Li MJ, Zhang R, Sheikho A, Tang JJ, Gao YQ, Huang WW, Gao JM
International journal of biological macromolecules 2025 Sep 8;328(Pt 2):147547
International journal of biological macromolecules 2025 Sep 8;328(Pt 2):147547
L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling.
Huang L, Li H, Yang W, Huang L, Chen Q, Li S, Zou Z, Zhao L, Zeng Z
Journal of microbiology and biotechnology 2025 Sep 22;35:e2504017
Journal of microbiology and biotechnology 2025 Sep 22;35:e2504017
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.
Jiang Y, Shi Y, Lv M, Wang T, Wang P, Yuan X, Gao F, Ma B
Cell biology and toxicology 2025 Sep 2;41(1):129
Cell biology and toxicology 2025 Sep 2;41(1):129
Timing of glucose intake drives distinct hepatic outcomes: Divergent glucose and lipid metabolism.
Zhang X, Ma C, Chang S, Li X, Wang Q
Molecular and cellular endocrinology 2025 Sep 15;607:112611
Molecular and cellular endocrinology 2025 Sep 15;607:112611
Helicobacter pylori infection impairs glucose homeostasis through gut microbiota dysbiosis.
Chen H, Wang Z, Su W, Li S, Ye Q, Zhang G, Zhou X
BMC microbiology 2025 Oct 14;25(1):663
BMC microbiology 2025 Oct 14;25(1):663
Quercetin's regulation of glucose and lipid metabolism in gestational diabetes mellitus: role of the PCSK9/LDLR axis.
Hong L, Xia S, Chen N, Wang Z, Li Z
Nutrition & metabolism 2025 Nov 24;22(1):159
Nutrition & metabolism 2025 Nov 24;22(1):159
Roseburia hominis enriched by baicalin reverses the non-response to metformin via upregulating linolenic acid metabolism.
Miao Z, Long J, Huang B, Yan D, Wang A
iScience 2025 Nov 21;28(11):113892
iScience 2025 Nov 21;28(11):113892
Metabolites from the Dendrobium Endophyte Pseudomonas protegens CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway.
Qin L, Zhou Y, Fan B, Zheng J, Diao R, Liu J, Wang F
Pharmaceuticals (Basel, Switzerland) 2025 May 29;18(6)
Pharmaceuticals (Basel, Switzerland) 2025 May 29;18(6)
Deubiquitinating Enzyme USP2 Alleviates Muscle Atrophy by Stabilizing PPAR-γ.
Yang S, Xiong L, Liao T, Li L, Li Y, Kang L, Yang G, Liang Z
Diabetes 2025 May 1;74(5):773-786
Diabetes 2025 May 1;74(5):773-786
Aerobic exercise improves energy and glucose homeostasis through hypothalamic Mitofusion 2-rescued endoplasmic reticulum stress in diet-induced obese mice.
Zhang S, Chen Y, Yang R, Ye L, Chen H, Jiang L, Bai D, Wu D
Diabetes, obesity & metabolism 2025 Mar;27(3):1251-1264
Diabetes, obesity & metabolism 2025 Mar;27(3):1251-1264
IL-37 inhibited inflammation to improve gestational diabetes mellitus through the GSK3/NF-κB pathway.
Song M, Zhang G
Diabetology & metabolic syndrome 2025 Jun 5;17(1):193
Diabetology & metabolic syndrome 2025 Jun 5;17(1):193
Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway.
Yu Y, Zhu G, Zhang Z, Wang H, Zeng L, Xia J, Liu X, Fang C, Liu S, Yang Y, Yu L
Scientific reports 2025 Jul 2;15(1):23083
Scientific reports 2025 Jul 2;15(1):23083
Comparison of chemical composition between imitation wild and transplanted Astragali Radix and their therapeutic effects on heart failure.
Zhang C, Zhu Y, Wang M, Chen R, Sun X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118827
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118827
Transgenerational inheritance of diabetes susceptibility in male offspring with maternal androgen exposure.
Zhang Y, Hu S, Han S, Liu C, Liang X, Li Y, Lin Z, Qin Y, Geng C, Liu Y, Cui L, Hu J, Zhang C, Wang Z, Liu X, Ma J, Chen ZJ, Zhao H
Cell discovery 2025 Feb 12;11(1):14
Cell discovery 2025 Feb 12;11(1):14
A novel covalent inhibitor alleviates type 2 diabetes mellitus by restraining GSK-3β.
Zhang S, Zhao F, Pan C, Wang Y, Yang Z, Yang J, Meng Y, Lv S, Huang J, Dong L, Li L, Dong Y
Biochemical pharmacology 2025 Dec;242(Pt 2):117205
Biochemical pharmacology 2025 Dec;242(Pt 2):117205
p53 Modulates the Gut-Liver Axis via PI3K/AKT/Wnt Signaling Pathways in Type 2 Diabetes.
Li Q, Zhang L, Sun Y, Du Z, Xu S, Wang X, Wei S, Tao Y, Li B, Jiang J, Di G, Huang Y, Xu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70898
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70898
Degraded Polysaccharides from Noni (Morinda citrifolia L.) juice Mitigate Glucose Metabolism Disorders by Regulating PI3K/AKT-Nrf2-GSK3β Signaling Pathways in HepG2 Cells.
Wei X, Du P, Luo Y, Zhao Y, Zhou X, Chen G, Zhang B
Foods (Basel, Switzerland) 2025 Aug 27;14(17)
Foods (Basel, Switzerland) 2025 Aug 27;14(17)
Electroacupuncture alleviates insulin resistance and impacts the hypothalamic IRS-1/PI3K/AKT pathway and miRNA-29a-3p in a rat model of type 2 diabetes.
Zhuang S, Liu S, Li R, Duan H
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2025 Apr;43(2):104-113
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2025 Apr;43(2):104-113
Lycium barbarum polysaccharide mitigates high-fat-diet-induced skeletal muscle atrophy by promoting AMPK/PINK1/Parkin-mediated mitophagy.
Ren Y, Wang K, Wu Y, Li J, Ma J, Wang L, Zhang C, Li J, Wei Y, Yang Y
International journal of biological macromolecules 2025 Apr;301:140488
International journal of biological macromolecules 2025 Apr;301:140488
Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction.
Li N, Fang X, Li H, Liu J, Chen N, Zhao X, Yang Q, Chen X
Metabolic brain disease 2025 Apr 3;40(4):168
Metabolic brain disease 2025 Apr 3;40(4):168
Mechanistic evaluation of Jiu Wei Qing Zhi Gao in non-alcoholic fatty liver disease: insights from network Pharmacology and experimental validation.
Chen Q, Hu Q, Zhang F, Lu W, Yuan Z, Qiao F
Hereditas 2025 Apr 12;162(1):59
Hereditas 2025 Apr 12;162(1):59
Network Pharmacology-Based Strategy to Explore the Effect and Mechanism of Zhizhu Granule Improving Glucose-Lipid Metabolism in Rats with Metabolic Syndrome.
Wang J, Liu Y, Xiu C, Wang X, Liu Y, Hu Y, Yang J, Lei Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:3833-3846
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:3833-3846
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38
American journal of translational research 2024;16(1):27-38
IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts.
Okino R, Mukai K, Oguri S, Masuda M, Watanabe S, Yoneyama Y, Nagaosa S, Miyamoto T, Mochizuki A, Takahashi SI, Hakuno F
Scientific reports 2024 Sep 5;14(1):20699
Scientific reports 2024 Sep 5;14(1):20699
HADHA promotes esophageal cancer progression by activating mTOR signaling and the SP1/MDM2 axis.
Ding X, Shao L, Wang J, Jin Y, Chen H, Li B
Acta biochimica et biophysica Sinica 2024 Sep 26;57(3):378-388
Acta biochimica et biophysica Sinica 2024 Sep 26;57(3):378-388
α-Klotho prevents diabetic retinopathy by reversing the senescence of macrophages.
Li Q, Wang P, Gong Y, Xu M, Wang M, Luan R, Liu J, Li X, Shao Y
Cell communication and signaling : CCS 2024 Sep 26;22(1):449
Cell communication and signaling : CCS 2024 Sep 26;22(1):449
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
Liu Z, Zhang Z, Tang R, Liu J, Yang Y
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
Procyanidin B1 and p-coumaric acid from whole highland barley ameliorated HFD-induced impaired glucose tolerance via small intestinal barrier and hepatic glucose metabolism.
Liu Z, Yang Y, Xu Y, Zhang Z, Tang R, Liu J, Jiang H, Zhao R
Food & function 2024 Sep 16;15(18):9272-9283
Food & function 2024 Sep 16;15(18):9272-9283
Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance.
Kaewlert W, Sakonsinsiri C, Lert-Itthiporn W, Mahalapbutr P, Ali S, Rungrotmongkol T, Jusakul A, Armartmuntree N, Pairojkul C, Feng G, Ma N, Pinlaor S, Murata M, Thanan R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117569
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117569
FGF19 Promotes the Proliferation and Insulin Secretion from Human Pancreatic β Cells Via the IRS1/GLUT4 Pathway.
Zeng T, Tang X, Bai X, Xiong H
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2024 Mar;132(3):152-161
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2024 Mar;132(3):152-161
Augmentation of scleral glycolysis promotes myopia through histone lactylation.
Lin X, Lei Y, Pan M, Hu C, Xie B, Wu W, Su J, Li Y, Tan Y, Wei X, Xue Z, Xu R, Di M, Deng H, Liu S, Yang X, Qu J, Chen W, Zhou X, Zhao F
Cell metabolism 2024 Mar 5;36(3):511-525.e7
Cell metabolism 2024 Mar 5;36(3):511-525.e7
Kallistatin Improves High-Fat-Induced Insulin Resistance via Epididymal Adipose Tissue-Derived Exosomes.
Yang ZW, Ji JJ, Jiang Y, Wu Y, Guo JQ, Ma GS, Yao YY
Human gene therapy 2024 Jun;35(11-12):388-400
Human gene therapy 2024 Jun;35(11-12):388-400
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes.
Chen Y, Yang F, Shi Y, Sheng J, Wang Y, Zhang L, Zhou J, Jin Y, Yan Y
Free radical biology & medicine 2024 Jul;219:163-179
Free radical biology & medicine 2024 Jul;219:163-179
m6A-Mediated IRS1 Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling.
Xiao Y, Zhu X, Li Q, Wang Z, Zuo Q, Liu X, Tan J
Frontiers in bioscience (Landmark edition) 2024 Jul 19;29(7):257
Frontiers in bioscience (Landmark edition) 2024 Jul 19;29(7):257
Inhibiting TRIM8 alleviates adipocyte inflammation and insulin resistance by regulating the DUSP14/MAPKs pathway.
Zhu M, Pu J, Zhang T, Shao H, Su R, Tang C
Adipocyte 2024 Dec;13(1):2381262
Adipocyte 2024 Dec;13(1):2381262
Aerobic exercise attenuates high-fat diet-induced glycometabolism impairments in skeletal muscle of rat: role of EGR-1/PTP1B signaling pathway.
Zhang L, Liu X, Hu J, Quan H, Lee SK, Korivi M, Wang L, Li T, Li W
Nutrition & metabolism 2024 Dec 31;21(1):113
Nutrition & metabolism 2024 Dec 31;21(1):113
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
Li J, Tian Z, Zhang T, Jin J, Zhang X, Xie P, Lin H, Gu J, Wu Y, Wang X, Zhang S, Yan X, Guo D, Wang Z, Zhang Q
Cellular & molecular biology letters 2024 Dec 3;29(1):148
Cellular & molecular biology letters 2024 Dec 3;29(1):148
Puerarin Attenuates Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress and Suppresses Inflammation by Modulating the JNK and IKKβ/NF-κB Pathways in Epididymal White Adipose Tissue of Mice on a High-Fat Diet.
Sun J, Liu Y, Zhang J, Shi H, Jiang R, Guo M, Liu Y, Liu B, Wang N, Ma R, Zhang D, Zhang F, Wang S, Wu Y
Molecular nutrition & food research 2024 Aug;68(16):e2400003
Molecular nutrition & food research 2024 Aug;68(16):e2400003
Network Pharmacological Analysis Combined with Experimental Verification to Explore the Effect of Ginseng Polypeptide on the Improvement of Diabetes Symptoms in db/db Mice.
Liu T, Zhu C, Duan Z, Ma P, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Aug 21;72(33):18537-18551
Journal of agricultural and food chemistry 2024 Aug 21;72(33):18537-18551
Liver ChREBP deficiency inhibits fructose-induced insulin resistance in pregnant mice and female offspring.
Li J, Zhang S, Sun Y, Li J, Feng Z, Li H, Zhang M, Yan T, Han J, Duan Y
EMBO reports 2024 Apr;25(4):2097-2117
EMBO reports 2024 Apr;25(4):2097-2117
Artesunate improves glucose and lipid metabolism in db/db mice by regulating the metabolic profile and the MAPK/PI3K/Akt signalling pathway.
Chen L, Wang J, Ren Y, Ma Y, Liu J, Jiang H, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155382
Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer's Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway.
He Y, Wang Y, Li X, Qi Y, Qu Z, Hu Y
Neuromolecular medicine 2024 Apr 23;26(1):15
Neuromolecular medicine 2024 Apr 23;26(1):15
Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo.
Ma L, La X, Zhang B, Xu W, Tian C, Fu Q, Wang M, Wu C, Chen Z, Chang H, Li JA
Frontiers in endocrinology 2023;14:1190827
Frontiers in endocrinology 2023;14:1190827
Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus.
Zhao Y, Liu Y, Deng J, Zhu C, Ma X, Jiang M, Fan D
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14263-14275
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14263-14275
Visceral adipose tissue-directed human kallistatin gene therapy improves adipose tissue remodeling and metabolic health in obese mice.
Wu Y, Jiang Y, Guo JQ, Yang ZW, Carvalho A, Qian LL, Ji JJ, Ji ZJ, Ma GS, Yao YY
Cellular signalling 2023 Jun;106:110637
Cellular signalling 2023 Jun;106:110637
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis.
Yang F, Wu Y, Chen Y, Xi J, Chu Y, Jin J, Yan Y
JHEP reports : innovation in hepatology 2023 Jul;5(7):100746
JHEP reports : innovation in hepatology 2023 Jul;5(7):100746
Single-cell multi-omics profiling reveals key regulatory mechanisms that poise germinal vesicle oocytes for maturation in pigs.
Yuan X, Chen N, Feng Y, Li N, Pan X, Tian Y, Wang J, Jiang Y, He D, Li J, Gao F
Cellular and molecular life sciences : CMLS 2023 Jul 22;80(8):222
Cellular and molecular life sciences : CMLS 2023 Jul 22;80(8):222
Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice.
Yan F, Liu J, Chen MX, Zhang Y, Wei SJ, Jin H, Nie J, Fu XL, Shi JS, Zhou SY, Jin F
Neural regeneration research 2023 Jan;18(1):183-188
Neural regeneration research 2023 Jan;18(1):183-188
Overexpression of Insulin Receptor Substrate 1 (IRS1) Relates to Poor Prognosis and Promotes Proliferation, Stemness, Migration, and Oxidative Stress Resistance in Cholangiocarcinoma.
Kaewlert W, Sakonsinsiri C, Lert-Itthiporn W, Ungarreevittaya P, Pairojkul C, Pinlaor S, Murata M, Thanan R
International journal of molecular sciences 2023 Jan 26;24(3)
International journal of molecular sciences 2023 Jan 26;24(3)
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Phenolic Constituents from Black Quinoa Alleviate Insulin Resistance in HepG2 Cells via Regulating IRS1/PI3K/Akt/GLUTs Signaling Pathways.
Cao M, Wang J, Jiang X, Sun Z, Zhao L, Chen G
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18780-18791
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18780-18791
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
Lin L, Wang X, Zhao W, Chen Y
Genetics research 2022;2022:1500768
Genetics research 2022;2022:1500768
Effect of crude polysaccharide from seaweed, Dictyopteris divaricata (CDDP) on gut microbiota restoration and anti-diabetic activity in streptozotocin (STZ)-induced T1DM mice.
Siddiqui NZ, Rehman AU, Yousuf W, Khan AI, Farooqui NA, Zang S, Xin Y, Wang L
Gut pathogens 2022 Sep 17;14(1):39
Gut pathogens 2022 Sep 17;14(1):39
Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice.
Hara T, Toyama H, Ohata Y, Ikeuchi T, Nakamura S, Joh T, Ohtsubo K
Bioscience, biotechnology, and biochemistry 2022 Oct 20;86(11):1570-1575
Bioscience, biotechnology, and biochemistry 2022 Oct 20;86(11):1570-1575
RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
Liu Y, Shi H, Hu Y, Yao R, Liu P, Yang Y, Li S
Cell stress & chaperones 2022 Nov;27(6):603-618
Cell stress & chaperones 2022 Nov;27(6):603-618
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
He H, Deng J, Yang M, An L, Ye X, Li X
Journal of ethnopharmacology 2022 Nov 15;298:115529
Journal of ethnopharmacology 2022 Nov 15;298:115529
Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study.
Ren X, Xing Y, He L, Xiu Z, Yang L, Han A, Jia Q, Dong Y
Journal of ethnopharmacology 2022 May 10;289:115029
Journal of ethnopharmacology 2022 May 10;289:115029
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway.
Ni J, Liu Z, Jiang M, Li L, Deng J, Wang X, Su J, Zhu Y, He F, Mao J, Gao X, Fan G
Journal of ginseng research 2022 Mar;46(2):235-247
Journal of ginseng research 2022 Mar;46(2):235-247
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Zhang W, Dun Y, You B, Qiu L, Ripley-Gonzalez JW, Cheng J, Fu S, Li C, Liu S
BMJ open diabetes research & care 2022 Mar;10(2)
BMJ open diabetes research & care 2022 Mar;10(2)
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
Gautheron J, Lima L, Akinci B, Zammouri J, Auclair M, Ucar SK, Ozen S, Altay C, Bax BE, Nemazanyy I, Lenoir V, Prip-Buus C, Acquaviva-Bourdain C, Lascols O, Fève B, Vigouroux C, Noel E, Jéru I
BMC medicine 2022 Mar 28;20(1):95
BMC medicine 2022 Mar 28;20(1):95
Ginsenoside compound K inhibits obesity-induced insulin resistance by regulation of macrophage recruitment and polarization via activating PPARγ.
Xu J, Dong J, Ding H, Wang B, Wang Y, Qiu Z, Yao F
Food & function 2022 Mar 21;13(6):3561-3571
Food & function 2022 Mar 21;13(6):3561-3571
Spatiotemporal regulation of insulin signaling by liquid-liquid phase separation.
Zhou K, Chen Q, Chen J, Liang D, Feng W, Liu M, Wang Q, Wang R, Ouyang Q, Quan C, Chen S
Cell discovery 2022 Jul 5;8(1):64
Cell discovery 2022 Jul 5;8(1):64
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Xu Y, Tang Z, Dai H, Hou J, Li F, Tang Z, Zhang D
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
Insulin receptor substrate 1(IRS1) is related with lymph node metastases and prognosis in esophageal squamous cell carcinoma.
Lei Y, Jamal M, Zeng X, He H, Xiao D, Zhang C, Zhang X, Tan H, Xie S, Zhang Q
Gene 2022 Aug 15;835:146651
Gene 2022 Aug 15;835:146651
Fermented noni (Morinda citrifolia L.) fruit juice improved oxidative stress and insulin resistance under the synergistic effect of Nrf2/ARE pathway and gut flora in db/db mice and HepG2 cells.
Zhang X, Zhang B, Li L, Li X, Zhang J, Chen G
Food & function 2022 Aug 1;13(15):8254-8273
Food & function 2022 Aug 1;13(15):8254-8273
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Cheng F, Dun Y, Cheng J, Ripley-Gonzalez JW, Jiang W, You B, Liu S
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Pentadecanoic acid promotes basal and insulin-stimulated glucose uptake in C2C12 myotubes.
Fu WC, Li HY, Li TT, Yang K, Chen JX, Wang SJ, Liu CH, Zhang W
Food & nutrition research 2021;65
Food & nutrition research 2021;65
The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats.
Zhang Z, Hu S, Fan P, Li L, Feng S, Xiao H, Zhu L
Disease markers 2021;2021:2821673
Disease markers 2021;2021:2821673
DPHC From Alpinia officinarum Ameliorates Oxidative Stress and Insulin Resistance via Activation of Nrf2/ARE Pathway in db/db Mice and High Glucose-Treated HepG2 Cells.
Zhang X, Zhang Y, Zhou M, Xie Y, Dong X, Bai F, Zhang J
Frontiers in pharmacology 2021;12:792977
Frontiers in pharmacology 2021;12:792977
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
Wang D, Song M, Shen LF, Han L, Zhu P, Jia X, Shang GK, Cao Y, Zhang W, Zhong M, Wang ZH
Frontiers in physiology 2021;12:786895
Frontiers in physiology 2021;12:786895
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
Zhang L, Xie Z, Yu H, Du H, Wang X, Cai J, Qiu Y, Chen R, Jiang X, Liu Z, Li Y, Chen T
Annals of translational medicine 2021 Sep;9(18):1429
Annals of translational medicine 2021 Sep;9(18):1429
BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
da Silva Rosa SC, Martens MD, Field JT, Nguyen L, Kereliuk SM, Hai Y, Chapman D, Diehl-Jones W, Aliani M, West AR, Thliveris J, Ghavami S, Rampitsch C, Dolinsky VW, Gordon JW
Autophagy 2021 Sep;17(9):2257-2272
Autophagy 2021 Sep;17(9):2257-2272
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Zhang M, Hou G, Hu P, Feng D, Wang J, Zhu W
The British journal of nutrition 2021 Sep 28;126(6):801-812
The British journal of nutrition 2021 Sep 28;126(6):801-812
Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats.
Cheng YC, Chiu YM, Dai ZK, Wu BN
Cells 2021 Oct 8;10(10)
Cells 2021 Oct 8;10(10)
KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis.
Senoo H, Murata D, Wai M, Arai K, Iwata W, Sesaki H, Iijima M
Molecular cell 2021 Nov 18;81(22):4622-4634.e8
Molecular cell 2021 Nov 18;81(22):4622-4634.e8
Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2.
Li B, Ye J, Liu R, Weng L, Cao Y, Jia S, Xu C, Liu Y, Yan S, Zheng M
Life sciences 2021 Nov 15;285:119918
Life sciences 2021 Nov 15;285:119918
Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.
Raber J, Perez R, Torres ERS, Krenik D, Boutros S, Patel E, Chlebowski AC, Torres ER, Perveen Z, Penn A, Paulsen DB, Bartlett MG, Jia E, Holden S, Hall R, Morré J, Wong C, Ho E, Choi J, Stevens JF, Noël A, Bobe G, Kisby G
Environmental health perspectives 2021 May;129(5):57009
Environmental health perspectives 2021 May;129(5):57009
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Li H, Dun Y, Zhang W, You B, Liu Y, Fu S, Qiu L, Cheng J, Ripley-Gonzalez JW, Liu S
Life sciences 2021 May 15;273:119314
Life sciences 2021 May 15;273:119314
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
Liu AD, Zhou J, Bi XY, Hou GQ, Li SS, Chen Q, Xu H, Cao X
Clinical and translational medicine 2021 Mar;11(3):e337
Clinical and translational medicine 2021 Mar;11(3):e337
A maternal high-fat/low-fiber diet impairs glucose tolerance and induces the formation of glycolytic muscle fibers in neonatal offspring.
Hu C, Yang Y, Chen M, Hao X, Wang S, Yang L, Yin Y, Tan C
European journal of nutrition 2021 Aug;60(5):2709-2718
European journal of nutrition 2021 Aug;60(5):2709-2718
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Zhu Y, Yang H, Deng J, Fan D
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I
eLife 2021 Aug 3;10
eLife 2021 Aug 3;10
CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling.
Huang Y, Lin L, Shen Z, Li Y, Cao H, Peng L, Qiu Y, Cheng X, Meng M, Lu D, Yin D
American journal of cancer research 2020;10(10):3328-3344
American journal of cancer research 2020;10(10):3328-3344
miR-203 inhibits cell proliferation and ERK pathway in prostate cancer by targeting IRS-1.
Meng Y, Hu X, Li S, Zeng X, Qiu L, Wei M, Wang Z, Han J
BMC cancer 2020 Oct 27;20(1):1028
BMC cancer 2020 Oct 27;20(1):1028
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
Zhang H, Hui J, Yang J, Deng J, Fan D
European journal of pharmacology 2020 Nov 15;887:173557
European journal of pharmacology 2020 Nov 15;887:173557
Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring.
Liu Y, Yang C, Feng X, Qi L, Guo J, Zhu D, Thai PN, Zhang Y, Zhang P, Sun M, Lv J, Zhang L, Xu Z, Lu X
Molecular nutrition & food research 2020 Jul;64(14):e2000196
Molecular nutrition & food research 2020 Jul;64(14):e2000196
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Qiao X, Zhou ZC, Niu R, Su YT, Sun Y, Liu HL, Teng JL, Ye JN, Shi H, Yang CD, Cheng XB
Frontiers in pharmacology 2019;10:855
Frontiers in pharmacology 2019;10:855
Suppression of miR-143 contributes to overexpression of IL-6, HIF-1α and NF-κB p65 in Cr(VI)-induced human exposure and tumor growth.
Wang L, Qiu JG, He J, Liu WJ, Ge X, Zhou FM, Huang YX, Jiang BH, Liu LZ
Toxicology and applied pharmacology 2019 Sep 1;378:114603
Toxicology and applied pharmacology 2019 Sep 1;378:114603
Therapeutic potential of NaoXinTong Capsule on the developed diabetic nephropathy in db/db mice.
Yang S, Chen Y, Duan Y, Ma C, Liu L, Li Q, Yang J, Li X, Zhao B, Wang Y, Qian K, Liu M, Zhu Y, Yang X, Han J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109389
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2019 Aug 1;424:152236
Toxicology 2019 Aug 1;424:152236
Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala.
Liang H, Mokrani A, Chisomo-Kasiya H, Ji K, Ge X, Ren M, Liu B, Xi B, Sun A
Fish physiology and biochemistry 2019 Apr;45(2):719-732
Fish physiology and biochemistry 2019 Apr;45(2):719-732
DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice.
Xu M, Wu H, Li M, Wen Y, Yu C, Xia L, Xia Q, Kong X
International journal of biological sciences 2018;14(13):1892-1900
International journal of biological sciences 2018;14(13):1892-1900
miR-146b Inhibits Glucose Consumption by Targeting IRS1 Gene in Porcine Primary Adipocytes.
Zhu YL, Chen T, Xiong JL, Wu D, Xi QY, Luo JY, Sun JJ, Zhang YL
International journal of molecular sciences 2018 Mar 9;19(3)
International journal of molecular sciences 2018 Mar 9;19(3)
NaoXinTong Capsules inhibit the development of diabetic nephropathy in db/db mice.
Yang S, Liu M, Chen Y, Ma C, Liu L, Zhao B, Wang Y, Li X, Zhu Y, Gao X, Kong D, Duan Y, Han J, Yang X
Scientific reports 2018 Jun 14;8(1):9158
Scientific reports 2018 Jun 14;8(1):9158
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Wei W, An XR, Jin SJ, Li XX, Xu M
Scientific reports 2018 Jan 8;8(1):9
Scientific reports 2018 Jan 8;8(1):9
Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy.
Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J, Duan Y
Scientific reports 2015 Jun 10;5:11219
Scientific reports 2015 Jun 10;5:11219
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 17509-1-AP(IRS1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-IRS1 (IP:17509-1-AP, 5ug; Detection:17509-1-AP 1:1000) with A549 cells lysate 3500ug.
- Sample type
- cell line
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IRS1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IRS1. This antibody recognizes human antigen. The IRS1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 17509-1-AP(IRS1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
