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- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- ABIN500072 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Insulin Receptor Substrate 1 (IRS1) (Center) antibody
- Antibody type
- Polyclonal
- Antigen
- IRS-1 antibody was raised against a 16 amino acid peptide from near the center of human IRS-1.
- Description
- Peptide affinity chromatography
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- Center
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store at 2 - 8°C for up to one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Integration of growth factor and nutrient signaling: implications for cancer biology.
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.
Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave.
Shamji AF, Nghiem P, Schreiber SL
Molecular cell 2003 Aug;12(2):271-80
Molecular cell 2003 Aug;12(2):271-80
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB
Proceedings of the National Academy of Sciences of the United States of America 2001 Apr 10;98(8):4640-5
Proceedings of the National Academy of Sciences of the United States of America 2001 Apr 10;98(8):4640-5
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.
Giovannone B, Scaldaferri ML, Federici M, Porzio O, Lauro D, Fusco A, Sbraccia P, Borboni P, Lauro R, Sesti G
Diabetes/metabolism research and reviews 2000 Nov-Dec;16(6):434-41
Diabetes/metabolism research and reviews 2000 Nov-Dec;16(6):434-41
Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave.
Waters SB, Pessin JE
Trends in cell biology 1996 Jan;6(1):1-4
Trends in cell biology 1996 Jan;6(1):1-4
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of IRS-1 in PC-3 cell lysate with AP30456PU-N at (A) 1, (B) 2 and (C) 4 ?g/ml.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunocytochemistry of IRS-1 in P815 cells with AP30456PU-N at 2 ?g/ml.
