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- Antibody Data
- Antigen structure
- References [511]
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- Western blot [1]
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- Immunoprecipitation [1]
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- Product number
- 12987-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12987-1-AP, RRID:AB_2136290
- Product name
- Lamin B1 antibody
- Antibody type
- Polyclonal
- Description
- Lamin B1 antibody (Cat. #12987-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 150ul
Submitted references Increased m6A-RNA methylation and FTO suppression is associated with myocardial inflammation and dysfunction during endotoxemia in mice.
MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis.
Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia Through Activating AMPK/Nrf2 Pathway in Rats.
Bombyx mori Akirin hijacks a viral peptide vSP27 encoded by BmCPV circRNA and activates the ROS-NF-κB pathway against viral infection.
Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis.
TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer.
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.
SNX25 regulates proinflammatory cytokine expression via the NF-κB signal in macrophages.
Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling.
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/β-catenin Pathway.
Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival.
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway.
Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway.
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation.
Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells.
TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma.
Yangonin modulates lipid homeostasis, ameliorates cholestasis and cellular senescence in alcoholic liver disease via activating nuclear receptor FXR.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells.
Exogenous H2 S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading.
18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.
TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling.
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide.
PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation.
Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway in rat hippocampus.
Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells.
Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level.
Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.
Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-κB signaling pathway.
Nicotinamide improves NAD+ levels to protect against acetaminophen-induced acute liver injury in mice.
Loss of PHLDA1 has a protective role in OGD/R-injured neurons via regulation of the GSK-3β/Nrf2 pathway.
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.
G-Quadruplexes Formation at the Upstream Region of Replication Origin (OriL) of the Pseudorabies Virus: Implications for Antiviral Targets.
Cilia locally synthesize proteins to sustain their ultrastructure and functions.
Golgi Phosphoprotein 3 Confers Radioresistance via Stabilizing EGFR in Lung Adenocarcinoma.
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability.
MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling.
RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.
Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo.
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus.
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses.
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer.
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
6-Gingerol attenuates ventilator-induced lung injury via anti-inflammation and antioxidative stress by modulating the PPARγ/NF-κBsignalling pathway in rats.
Chromothripsis drives the evolution of gene amplification in cancer.
Protein kinase D participates in cardiomyocyte hypertrophy by regulating extracellular signal-regulated and myocyte enhancer factor 2D.
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Silibinin treatment protects human skin cells from UVB injury through upregulation of estrogen receptors.
ATF3 drives senescence by reconstructing accessible chromatin profiles.
5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expression in TET2-Deficient Erythroleukemia Cells.
Salubrinal Alleviates Collagen-Induced Arthritis through Promoting P65 Degradation in Osteoclastogenesis.
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways.
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening.
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus.
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Activation of yes-associated protein mediates sphingosine-1-phosphate-induced proliferation and migration of pulmonary artery smooth muscle cells and its potential mechanisms.
miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.
T-17, a spirostanol saponin, inhibits p53-independent proliferation and p53-dependent migration of gastric cancer cells.
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells.
Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells.
Particulate matter promotes hyperpigmentation via AhR/MAPK signaling activation and by increasing α-MSH paracrine levels in keratinocytes.
YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
Fenofibrate inhibits TGF-β-induced myofibroblast differentiation and activation in human lung fibroblasts in vitro.
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L.
C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation.
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling.
Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways.
Inhibition of miR-155 alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-κB signaling.
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice.
Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.
Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model.
Polychlorinated biphenyl quinone induced the acquisition of cancer stem cells properties and epithelial-mesenchymal transition through Wnt/β-catenin.
Serotonin transporter regulation by cholesterol-independent lipid signaling.
P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.
Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma.
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway.
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway.
Localization of the WD repeat-containing protein 5 to the Virion Assembly Compartment Facilitates Human Cytomegalovirus Assembly.
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1.
Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1.
Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells.
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response.
The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior.
A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.
Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model.
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases.
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP.
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway.
High-frequency near-infrared diode laser irradiation suppresses IL-1β-induced inflammatory cytokine expression and NF-κB signaling pathways in human primary chondrocytes.
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Repeated neonatal sevoflurane induced neurocognitive impairment through NF-κB-mediated pyroptosis.
Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer.
Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice.
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis.
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway.
Myricetin protects against H2 O2 -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration.
LncRNA AC010789.1 Promotes Colorectal Cancer Progression by Targeting MicroRNA-432-3p/ZEB1 Axis and the Wnt/β-Catenin Signaling Pathway.
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats.
Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation.
Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Reduced hydration-induced decreased caveolin-1 expression causes epithelial-to-mesenchymal transition.
Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma.
Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo.
Linalool Prevents Cisplatin Induced Muscle Atrophy by Regulating IGF-1/Akt/FoxO Pathway.
Repositioning an Immunomodulatory Drug Vidofludimus as a Farnesoid X Receptor Modulator With Therapeutic Effects on NAFLD.
Lycopene Exerts Neuroprotective Effects After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the Nuclear Factor Erythroid-2 Related Factor 2/Nuclear Factor-κ-Gene Binding Pathway.
Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins.
Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway.
Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication.
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma.
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3.
Tacrolimus ameliorates tubulointerstitial inflammation in diabetic nephropathy via inhibiting the NFATc1/TRPC6 pathway.
Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Circular RNA GLIS2 promotes colorectal cancer cell motility via activation of the NF-κB pathway.
Facile Cholesterol Loading with a New Probe ezFlux Allows for Streamlined Cholesterol Efflux Assays.
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.
Down-regulation of exosomal miR-200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis.
RNA demethylase Alkbh5 is widely expressed in neurons and decreased during brain development.
Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation.
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis.
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production.
Aryl hydrocarbon receptor signaling activation in systemic sclerosis attenuates collagen production and is a potential antifibrotic target.
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence.
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Pin1 promotes pancreatic cancer progression and metastasis by activation of NF-κB-IL-18 feedback loop.
DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/ Polyps with Dysplasia.
Regulation of a PRMT5/NF-κB Axis by Phosphorylation of PRMT5 at Serine 15 in Colorectal Cancer.
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics.
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Nuclear-localized costimulatory molecule 4-1BBL promotes colon cancer cell proliferation and migration by regulating nuclear Gsk3β, and is linked to the poor outcomes associated with colon cancer.
Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression.
[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin.
AEBP1 Promotes the Occurrence and Development of Abdominal Aortic Aneurysm by Modulating Inflammation via the NF-κB Pathway.
1,25-Dihydroxyvitamin D attenuates diabetic cardiac autophagy and damage by vitamin D receptor-mediated suppression of FoxO1 translocation.
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Novel role of ASH1L histone methyltransferase in anaplastic thyroid carcinoma.
RGS12 Is a Novel Critical NF-κB Activator in Inflammatory Arthritis.
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
SIRT2 suppresses expression of inflammatory factors via Hsp90-glucocorticoid receptor signalling.
The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction.
EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer.
Deficiency of microRNA-628-5p promotes the progression of gastric cancer by upregulating PIN1.
Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia.
Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling.
Poly (ADP-ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation-associated chemotherapy-induced autophagy in leukaemia cells.
USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells.
The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry.
Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter.
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas.
Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease.
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.
A DNAH17 missense variant causes flagella destabilization and asthenozoospermia.
UBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma.
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-κB pathway.
Promotion of esophageal adenocarcinoma metastasis via Wnt/ß-catenin signal pathway by sorting nexins 3.
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Expressional Localization and Functionally Identifying an RNA Editing Enzyme BmADARa of the Silkworm Bombyx mori.
GADD45G Interacts with E-cadherin to Suppress the Migration and Invasion of Esophageal Squamous Cell Carcinoma.
Ribosome profiling analysis identified a KRAS-interacting microprotein that represses oncogenic signaling in hepatocellular carcinoma cells.
A novel Sprouty4-ERK1/2-Wnt/β-catenin regulatory loop in marrow stromal progenitor cells controls osteogenic and adipogenic differentiation.
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.
SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia.
Interleukin-17 suppresses grass carp reovirus infection in Ctenopharyngodon idellus kidney cells by activating NF-κB signaling.
Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.
p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma.
Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats.
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Nuclear CD44 Mediated by Importin β Participated in Naïve Genes Transcriptional Regulation in C3A-iCSCs.
Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes.
Revealing Antidepressant Mechanisms of Baicalin in Hypothalamus Through Systems Approaches in Corticosterone- Induced Depressed Mice.
Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells.
The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster.
DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS.
Leptin-Induced Angiogenesis of EA.Hy926 Endothelial Cells via the Akt and Wnt Signaling Pathways In Vitro and In Vivo.
Aerobic Exercise Improves Synaptic-Related Proteins of Diabetic Rats by Inhibiting FOXO1/NF-κB/NLRP3 Inflammatory Signaling Pathway and Ameliorating PI3K/Akt Insulin Signaling Pathway.
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma.
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
A hidden human proteome encoded by 'non-coding' genes.
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
AEBP1, a prognostic indicator, promotes colon adenocarcinoma cell growth and metastasis through the NF-κB pathway.
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Follicle-stimulating hormone promotes renal tubulointerstitial fibrosis in aging women via the AKT/GSK-3β/β-catenin pathway.
Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury.
P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Arsenic trioxide inhibits angiogenesis in vitro and in vivo by upregulating FoxO3a.
TMEM18 inhibits osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells by inactivating β-catenin.
Type I collagen or gelatin stimulates mouse peritoneal macrophages to aggregate and produce pro-inflammatory molecules through upregulated ROS levels.
The protective effects of L-carnitine on myocardial ischaemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-κB pathway and the activation of Nrf2 pathway.
Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism.
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion.
DYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild-type NSCLC cells to AZD9291.
Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway.
Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa B signaling pathway.
ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma.
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
Peroxisome proliferator activated receptor γ promotes mineralization and differentiation in cementoblasts via inhibiting Wnt/β-catenin signaling pathway.
PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy.
Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy.
Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels.
A cellular model for Wilson's disease using patient-derived induced pluripotent stem cells revealed aberrant β-catenin pathway during osteogenesis.
Ginsenoside Rk3 ameliorates high-fat-diet/streptozocin induced type 2 diabetes mellitus in mice via the AMPK/Akt signaling pathway.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Sodium ferulate protects against influenza virus infection by activation of the TLR7/9-MyD88-IRF7 signaling pathway and inhibition of the NF-κB signaling pathway.
Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.
Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation.
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia.
Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence.
In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways.
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells.
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells.
IL-1β receptor antagonist (IL-1Ra) combined with autophagy inducer (TAT-Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes.
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells.
Attenuation of Atherosclerosis by Protocatechuic Acid via Inhibition of M1 and Promotion of M2 Macrophage Polarization.
The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest.
Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model.
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Anacardic acid inhibits RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced bone loss in vivo.
The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia.
Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling.
High-mobility group box 1 protein modulated proliferation and radioresistance in esophageal squamous cell carcinoma.
Knockdown of Golgi phosphoprotein 73 blocks the trafficking of matrix metalloproteinase-2 in hepatocellular carcinoma cells and inhibits cell invasion.
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner.
Glycyrrhizin Protects Mice Against Experimental Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1 (HMGB1) Expression and Neuronal HMGB1 Release.
An Immunosuppressive Tick Salivary Gland Protein DsCystatin Interferes With Toll-Like Receptor Signaling by Downregulating TRAF6.
Overexpression of β-Catenin Decreases the Radiosensitivity of Human Nasopharyngeal Carcinoma CNE-2 Cells.
Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway.
Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells.
Prostaglandin F2α Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets.
IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3.
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.
Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus.
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Astrocyte elevated gene-1 participates in the production of pro-inflammatory cytokines in dental pulp cells via NF-κB signalling pathway.
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Salvianolic Acid B-Alleviated Angiotensin II Induces Cardiac Fibrosis by Suppressing NF-κB Pathway In Vitro.
ERα is a negative regulator of PD-L1 gene transcription in breast cancer.
Dynamic changes of proteasome and protective effect of bortezomib, a proteasome inhibitor, in mice with acute pancreatitis.
TRPV2-induced Ca2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.
PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation.
Redox-active trace metal-induced release of high mobility group box 1(HMGB1) and inflammatory cytokines in fibroblast-like synovial cells is Toll-like receptor 4 (TLR4) dependent.
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Tetrachlorobenzoquinone-Induced Nrf2 Confers Neuron-like PC12 Cells Resistance to Endoplasmic Reticulum Stress via Regulating Glutathione Synthesis and Protein Thiol Homeostasis.
Follicle-stimulating hormone enhances hepatic gluconeogenesis by GRK2-mediated AMPK hyperphosphorylation at Ser485 in mice.
Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways.
Folic acid supplementation repressed hypoxia-induced inflammatory response via ROS and JAK2/STAT3 pathway in human promyelomonocytic cells.
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos.
Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells.
Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Exosomes from C2C12 myoblasts enhance osteogenic differentiation of MC3T3-E1 pre-osteoblasts by delivering miR-27a-3p.
Calpain and JNK pathways participate in isoflurane - induced nucleus translocation of apoptosis-inducing factor in the brain of neonatal rats.
Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling.
Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor.
Excessive endoplasmic reticulum stress and decreased neuroplasticity-associated proteins in prefrontal cortex of obese rats and the regulatory effects of aerobic exercise.
Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway.
Fam83h mutation inhibits the mineralization in ameloblasts by activating Wnt/β-catenin signaling pathway.
Long noncoding RNA lncARSR promotes hepatic cholesterol biosynthesis via modulating Akt/SREBP-2/HMGCR pathway.
An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness.
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
Sub-lethal ultraviolet B irradiation and Poly I:C treatment synergistically induced apoptosis of HaCaT cells through NF-κB pathway.
Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinoma.
Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation.
Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats.
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Activation of peroxisome proliferation-activated receptor-γ inhibits transforming growth factor-β1-induced airway smooth muscle cell proliferation by suppressing Smad-miR-21 signaling.
PTEN-L promotes type I interferon responses and antiviral immunity.
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
IRF1 up-regulates isg15 gene expression in dsRNA stimulation or CSFV infection by targeting nucleotides -487 to -325 in the 5' flanking region.
Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway.
LINC01016 promotes the malignant phenotype of endometrial cancer cells by regulating the miR-302a-3p/miR-3130-3p/NFYA/SATB1 axis.
The interactome and spatial redistribution feature of Ca2+ receptor protein calmodulin reveals a novel role in invadopodia-mediated invasion.
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.
Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway.
Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling.
PNMA1, regulated by miR-33a-5p, promotes proliferation and EMT in hepatocellular carcinoma by activating the Wnt/β-catenin pathway.
The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response.
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells.
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.
The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation.
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway.
Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration.
TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3.
Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ.
Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.
Necrostatin-1 attenuates early brain injury after subarachnoid hemorrhage in rats by inhibiting necroptosis.
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
CDKL1 promotes tumor proliferation and invasion in colorectal cancer.
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling.
Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.
Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats.
Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms.
Cooperative regulation of Gja1 expression by members of the AP-1 family cJun and cFos in TM3 Leydig and TM4 Sertoli cells.
2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Overexpression of Rsf-1 correlates with poor survival and promotes invasion in non-small cell lung cancer.
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
E-Prostanoid 3 Receptor Mediates Sprouting Angiogenesis Through Suppression of the Protein Kinase A/β-Catenin/Notch Pathway.
Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages.
Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells.
Nrf2-Knockout Protects from Intestinal Injuries in C57BL/6J Mice Following Abdominal Irradiation with γ Rays.
Correction: Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells.
The electrophilic character of quinones is essential for the suppression of Bach1.
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining.
Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer.
The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins.
Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells.
Repression of YAP by NCTD disrupts NSCLC progression.
The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling.
A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury.
Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.
Respiratory Syncytial Virus Nonstructural Protein 1 Blocks Glucocorticoid Receptor Nuclear Translocation by Targeting IPO13 and May Account for Glucocorticoid Insensitivity.
Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells.
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.
Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.
Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.
Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma.
The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway.
Toll-like receptor 2-mediated MAPKs and NF-κB activation requires the GNAO1-dependent pathway in human mast cells.
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
The absence of p53 during Human Cytomegalovirus infection leads to decreased UL53 expression, disrupting UL50 localization to the inner nuclear membrane, and thereby inhibiting capsid nuclear egress.
Salusin-β contributes to vascular inflammation associated with pulmonary arterial hypertension in rats.
Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.
P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.
AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation.
Go is required for the release of IL-8 and TNF-α, but not degranulation in human mast cells.
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons.
Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation.
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes.
Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IκB/NF-κB signaling.
PRELP (proline/arginine-rich end leucine-rich repeat protein) promotes osteoblastic differentiation of preosteoblastic MC3T3-E1 cells by regulating the β-catenin pathway.
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways.
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.
The E3 Ubiquitin Ligase c-Cbl Inhibits Microglia-Mediated CNS Inflammation by Regulating PI3K/Akt/NF-κB Pathway.
Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein.
Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells.
A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha.
Identification and characterization of an endoplasmic reticulum localization motif.
Mechanistic Study of the Phytocompound, 2- β -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches.
The Overexpression of IQGAP1 and β-Catenin Is Associated with Tumor Progression in Hepatocellular Carcinoma In Vitro and In Vivo.
Demethylzeylasteral (T-96) Treatment Ameliorates Mice Lupus Nephritis Accompanied by Inhibiting Activation of NF-κB Pathway.
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver.
miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.
Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma.
Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells.
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
The effects of focal adhesion kinase on the motility, proliferation and apoptosis of Caco2 and SMMC-7721 cells.
WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis.
Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3.
CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDAC1-associated repression of C/EBPα.
Role of α-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis.
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/β-catenin signaling pathway.
Pao Pereira Extract Suppresses Castration-Resistant Prostate Cancer Cell Growth, Survival, and Invasion Through Inhibition of NFκB Signaling.
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro.
Vascular endothelial growth factor receptor-1 activation promotes migration and invasion of breast cancer cells through epithelial-mesenchymal transition.
Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L.
Conditioned medium of Wnt/β-catenin signaling-activated olfactory ensheathing cells promotes synaptogenesis and neurite growth in vitro.
Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model.
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
Adeno-associated virus Rep78 restricts adenovirus E1B55K-mediated p53 nuclear exportation.
Induction of apoptosis in infantile hemangioma endothelial cells by propranolol.
Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation.
1,2,3,4,6-penta-O-galloyl-β-D-glucose protects PC12 Cells from MPP(+)-mediated cell death by inducing heme oxygenase-1 in an ERK- and Akt-dependent manner.
Hypoxia increases CX3CR1 expression via HIF-1 and NF‑κB in androgen-independent prostate cancer cells.
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
Activation of the Wnt/β-catenin signaling pathway is associated with glial proliferation in the adult spinal cord of ALS transgenic mice.
Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kappaB AND AP-1 through inhibition of MAPKS and AKT/IkappaBalpha signaling pathways in macrophages.
KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways.
Dubey PK, Patil M, Singh S, Dubey S, Ahuja P, Verma SK, Krishnamurthy P
Molecular and cellular biochemistry 2022 Jan;477(1):129-141
Molecular and cellular biochemistry 2022 Jan;477(1):129-141
MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis.
Yue T, Sun F, Wang F, Yang C, Luo J, Rong S, Zhou H, Xiao J, Wang X, Zhou Q, Yang P, Zhang S, Li W, Xiong F, Yu Q, Wang CY
Cell death and differentiation 2022 Jan;29(1):218-229
Cell death and differentiation 2022 Jan;29(1):218-229
Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia Through Activating AMPK/Nrf2 Pathway in Rats.
Li K, Jiang J, Shi Z, Zhan L, Peng L, Sun W, Tang Y, Zuo X, Xu E
Antioxidants & redox signaling 2022 Jan 4;
Antioxidants & redox signaling 2022 Jan 4;
Bombyx mori Akirin hijacks a viral peptide vSP27 encoded by BmCPV circRNA and activates the ROS-NF-κB pathway against viral infection.
Zhang Y, Zhang X, Dai K, Zhu M, Liang Z, Pan J, Zhang Z, Xue R, Cao G, Hu X, Gong C
International journal of biological macromolecules 2022 Jan 1;194:223-232
International journal of biological macromolecules 2022 Jan 1;194:223-232
Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis.
Yu S, Lv Z, Gao Z, Shi J, Sheng Q, Zheng L, Zhou J, Wang X
Frontiers in pediatrics 2021;9:710382
Frontiers in pediatrics 2021;9:710382
TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer.
Yang B, Chen J, Teng Y
Journal of immunology research 2021;2021:9994004
Journal of immunology research 2021;2021:9994004
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Li X, Wang X, Miao L, Guo Y, Yuan R, Ren J, Huang Y, Tian H
Oxidative medicine and cellular longevity 2021;2021:4714649
Oxidative medicine and cellular longevity 2021;2021:4714649
YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.
Zhang T, Beeharry MK, Wang Z, Zhu Z, Li J, Li C
International journal of biological sciences 2021;17(7):1629-1643
International journal of biological sciences 2021;17(7):1629-1643
SNX25 regulates proinflammatory cytokine expression via the NF-κB signal in macrophages.
Nishimura K, Tanaka T, Takemura S, Tatsumi K, Wanaka A
PloS one 2021;16(3):e0247840
PloS one 2021;16(3):e0247840
Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling.
Fu Y, Jia J
Frontiers in neuroscience 2021;15:638772
Frontiers in neuroscience 2021;15:638772
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Wang H, Jiang Z, Pang Z, Qi G, Hua B, Yan Z, Yuan H
Journal of inflammation research 2021;14:745-760
Journal of inflammation research 2021;14:745-760
Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/β-catenin Pathway.
Xie X, Zhou Z, Song Y, Zhang X, Dang C, Zhang H
Journal of Cancer 2021;12(15):4574-4584
Journal of Cancer 2021;12(15):4574-4584
Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival.
Jiang J, Dong C, Zhai L, Lou J, Jin J, Cheng S, Chen Z, Guo X, Lin D, Ding J, Gao W
Frontiers in pharmacology 2021;12:735530
Frontiers in pharmacology 2021;12:735530
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Kong L, Zhang H, Lu C, Shi K, Huang H, Zheng Y, Wang Y, Wang D, Wang H, Huang W
Frontiers in pharmacology 2021;12:724514
Frontiers in pharmacology 2021;12:724514
Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway.
Wang J, Jiang W, Xin J, Xue W, Shi C, Wen J, Huang Y, Hu C
Frontiers in pharmacology 2021;12:717276
Frontiers in pharmacology 2021;12:717276
Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway.
Chen P, Wen Z, Shi W, Li Z, Chen X, Gao Y, Xu S, Gong Q, Deng J
Frontiers in pharmacology 2021;12:674570
Frontiers in pharmacology 2021;12:674570
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
Li R, Yang W, Yin Y, Ma X, Zhang P, Tao K
Frontiers in pharmacology 2021;12:651444
Frontiers in pharmacology 2021;12:651444
Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation.
Cao L, Xu C, Yi P, Li H, Lin Y, Cai G, Wang S, Ou D, Li M, Chen J
American journal of cancer research 2021;11(4):1206-1225
American journal of cancer research 2021;11(4):1206-1225
Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells.
Gao Y, Chen MK, Chu YY, Yang L, Yu D, Liu Y, Hung MC
American journal of cancer research 2021;11(1):236-250
American journal of cancer research 2021;11(1):236-250
TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma.
Bao S, Jiang X, Jin S, Tu P, Lu J
Frontiers in oncology 2021;11:694145
Frontiers in oncology 2021;11:694145
Yangonin modulates lipid homeostasis, ameliorates cholestasis and cellular senescence in alcoholic liver disease via activating nuclear receptor FXR.
Kong L, Dong R, Huang K, Wang X, Wang D, Yue N, Wang C, Sun P, Gu J, Luo H, Liu K, Wu J, Sun H, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Sep;90:153629
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Sep;90:153629
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells.
Wu J, Wu C, Xing F, Cao L, Zeng W, Guo L, Li P, Zhong Y, Jiang H, Luo M, Shi G, Bu L, Ji Y, Hou P, Peng H, Huang J, Li C, Guo D
Cell research 2021 Sep;31(9):998-1010
Cell research 2021 Sep;31(9):998-1010
Exogenous H2 S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Zhang L, Jiang X, Liu N, Li M, Kang J, Chen L, Tang J, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
Zeng S, Chen L, Sun Q, Zhao H, Yang H, Ren S, Liu M, Meng X, Xu H
European journal of pharmacology 2021 Sep 5;906:174253
European journal of pharmacology 2021 Sep 5;906:174253
HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading.
Xu L, Zhang L, Zhang X, Li G, Wang Y, Dong J, Wang H, Hu Z, Cao X, Zhang S, Shi F
International journal of molecular sciences 2021 Sep 29;22(19)
International journal of molecular sciences 2021 Sep 29;22(19)
18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.
Chen B, Zhu D, Xie C, Shi Y, Ni L, Zhang H, Li S, Lu J, Xiao J, Xia W, Huang C, Wang X
Food & function 2021 Sep 20;12(18):8399-8410
Food & function 2021 Sep 20;12(18):8399-8410
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.
Sun M, Guo M, Ma G, Zhang N, Pan F, Fan X, Wang R
Toxicology and applied pharmacology 2021 Sep 1;426:115637
Toxicology and applied pharmacology 2021 Sep 1;426:115637
TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling.
Hu S, Li Y, Wang B, Peng K
International immunopharmacology 2021 Oct;99:108048
International immunopharmacology 2021 Oct;99:108048
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Wen L, Yang QH, Ma XL, Li T, Xiao S, Sun CF
International immunopharmacology 2021 Oct;99:107993
International immunopharmacology 2021 Oct;99:107993
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Fan S, Liu X, Wang Y, Ren X, Liu Y, Dong Y, Fan Q, Wei J, Ma J, Yu A, Song R, Sui H, Shen M, Fang F, Xia Q, She G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
Yu S, Lu Y, Su A, Chen J, Li J, Zhou B, Liu X, Xia Q, Li Y, Li J, Huang M, Ye Y, Zhao Q, Jiang S, Yan X, Wang X, Di C, Pan J, Su S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Oct;8(19):e2101848
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Oct;8(19):e2101848
Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide.
Suzuki T, Yamashita S, Hattori K, Matsuda N, Hattori Y
Naunyn-Schmiedeberg's archives of pharmacology 2021 Oct;394(10):2129-2139
Naunyn-Schmiedeberg's archives of pharmacology 2021 Oct;394(10):2129-2139
PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation.
Chen Q, Lu H, Duan C, Zhu X, Zhang Y, Li M, Zhang D
Inflammation 2021 Oct 6;
Inflammation 2021 Oct 6;
Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway in rat hippocampus.
Wang J, Chen R, Liu C, Wu X, Zhang Y
European journal of pharmacology 2021 Oct 15;909:174396
European journal of pharmacology 2021 Oct 15;909:174396
Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells.
Sawamoto A, Kanazaki A, Nakanishi M, Amakura Y, Yoshimura M, Uchiyama N, Hakamatsuka T, Okuyama S, Nakajima M
European journal of pharmacology 2021 Oct 15;909:174382
European journal of pharmacology 2021 Oct 15;909:174382
Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level.
Liu Z, Xia X, Lv X, Song E, Song Y
Environmental pollution (Barking, Essex : 1987) 2021 Oct 15;287:117345
Environmental pollution (Barking, Essex : 1987) 2021 Oct 15;287:117345
Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.
Okubo Y, Ohtake F, Igarashi K, Yasuhiko Y, Hirabayashi Y, Saga Y, Kanno J
Development (Cambridge, England) 2021 Oct 1;148(19)
Development (Cambridge, England) 2021 Oct 1;148(19)
Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-κB signaling pathway.
Yuan L, Zhang L, Yao N, Wu L, Liu J, Liu F, Zhang H, Hu X, Xiong Y, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153726
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153726
Nicotinamide improves NAD+ levels to protect against acetaminophen-induced acute liver injury in mice.
Xu J, Zhang L, Jiang R, Hu K, Hu D, Liao C, Jiang S, Yang Y, Huang J, Tang L, Li L
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Loss of PHLDA1 has a protective role in OGD/R-injured neurons via regulation of the GSK-3β/Nrf2 pathway.
Yang F, Chen R
Human & experimental toxicology 2021 Nov;40(11):1909-1920
Human & experimental toxicology 2021 Nov;40(11):1909-1920
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
Cui Q, Yan L
Cell and tissue research 2021 Nov;386(2):349-363
Cell and tissue research 2021 Nov;386(2):349-363
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
Meng X, Zhang L, Han B, Zhang Z
Environmental toxicology 2021 Nov;36(11):2266-2277
Environmental toxicology 2021 Nov;36(11):2266-2277
AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
Fang P, Deng WJ, Fan N, Shi J, Shi HY, Ou L, Pan JL, Yang SY
Environmental toxicology 2021 Nov;36(11):2225-2235
Environmental toxicology 2021 Nov;36(11):2225-2235
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
Park J, Lee J, Kim JH, Lee J, Park H, Lim C
Nucleic acids research 2021 Nov 8;49(19):11294-11311
Nucleic acids research 2021 Nov 8;49(19):11294-11311
Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.
Lu Z, Huang L, Li Y, Xu Y, Zhang R, Zhou Q, Sun Q, Lu Y, Chen J, Shen Y, Li J, Zhao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov 5;:e2102669
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov 5;:e2102669
G-Quadruplexes Formation at the Upstream Region of Replication Origin (OriL) of the Pseudorabies Virus: Implications for Antiviral Targets.
Zhu Y, Liu W, Zhang C
Viruses 2021 Nov 4;13(11)
Viruses 2021 Nov 4;13(11)
Cilia locally synthesize proteins to sustain their ultrastructure and functions.
Hao K, Chen Y, Yan X, Zhu X
Nature communications 2021 Nov 30;12(1):6971
Nature communications 2021 Nov 30;12(1):6971
Golgi Phosphoprotein 3 Confers Radioresistance via Stabilizing EGFR in Lung Adenocarcinoma.
Chen G, Kong P, Yang M, Hu W, Prise KM, Yu KN, Cui S, Qin F, Meng G, Almahi WA, Nie L, Han W
International journal of radiation oncology, biology, physics 2021 Nov 26;
International journal of radiation oncology, biology, physics 2021 Nov 26;
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Chen Z, Tian L, Wang L, Ma X, Lei F, Chen X, Fu R
Inflammation 2021 Nov 16;
Inflammation 2021 Nov 16;
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability.
Wu B, Yang C, Fang Y, Ding W, Zhang Y
Environmental toxicology 2021 May;36(5):840-849
Environmental toxicology 2021 May;36(5):840-849
MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling.
Li D, Chen S, Zhang W, Zhang C, Sun T, Du Y, Ding R, Gao Y, Jin Y, Duan G
Cellular & molecular immunology 2021 May;18(5):1320-1322
Cellular & molecular immunology 2021 May;18(5):1320-1322
RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.
Kim JI, Nakahama T, Yamasaki R, Costa Cruz PH, Vongpipatana T, Inoue M, Kanou N, Xing Y, Todo H, Shibuya T, Kato Y, Kawahara Y
PLoS genetics 2021 May;17(5):e1009516
PLoS genetics 2021 May;17(5):e1009516
Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo.
Zhang C, Li Q, Qin G, Zhang Y, Li C, Han L, Wang R, Wang S, Chen H, Liu K, He C
Chinese medicine 2021 May 31;16(1):41
Chinese medicine 2021 May 31;16(1):41
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Zhang J, Ma X, Fan D
Foods (Basel, Switzerland) 2021 May 26;10(6)
Foods (Basel, Switzerland) 2021 May 26;10(6)
Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus.
Wang Q, Xin Q, Shang W, Wan W, Xiao G, Zhang LK
Viruses 2021 May 25;13(6)
Viruses 2021 May 25;13(6)
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Molecules (Basel, Switzerland) 2021 May 17;26(10)
G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses.
Cai H, Liu X, Zhang F, Han QY, Liu ZS, Xue W, Guo ZL, Zhao JM, Sun LM, Wang N, Mao J, He K, Xia T, Chen Y, Chen L, Li AL, Zhou T, Zhang XM, Li WH, Li T
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2453-2467
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2453-2467
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer.
Shi W, Zhang G, Ma Z, Li L, Liu M, Qin L, Yu Z, Zhao L, Liu Y, Zhang X, Qin J, Ye H, Jiang X, Zhou H, Sun H, Jiao Z
Nature communications 2021 May 14;12(1):2812
Nature communications 2021 May 14;12(1):2812
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Kishi S, Nishiguchi Y, Honoki K, Mori S, Fujiwara-Tani R, Sasaki T, Fujii K, Kawahara I, Goto K, Nakashima C, Kido A, Tanaka Y, Luo Y, Kuniyasu H
International journal of molecular sciences 2021 May 13;22(10)
International journal of molecular sciences 2021 May 13;22(10)
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
Qin W, Tong X, Liang R, Tang K, Wu X, Jia Y, Tan N
Journal of ethnopharmacology 2021 May 10;271:113827
Journal of ethnopharmacology 2021 May 10;271:113827
6-Gingerol attenuates ventilator-induced lung injury via anti-inflammation and antioxidative stress by modulating the PPARγ/NF-κBsignalling pathway in rats.
Hong W, Zhi FX, Kun TH, Hua FJ, Huan Ling L, Fang F, Wen C, Jie W, Yang LC
International immunopharmacology 2021 Mar;92:107367
International immunopharmacology 2021 Mar;92:107367
Chromothripsis drives the evolution of gene amplification in cancer.
Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW
Nature 2021 Mar;591(7848):137-141
Nature 2021 Mar;591(7848):137-141
Protein kinase D participates in cardiomyocyte hypertrophy by regulating extracellular signal-regulated and myocyte enhancer factor 2D.
Yuan H, Xiang Q, Yang L, Geng J
Revista portuguesa de cardiologia 2021 Mar;40(3):191-200
Revista portuguesa de cardiologia 2021 Mar;40(3):191-200
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Shao Z, Wang B, Shi Y, Xie C, Huang C, Chen B, Zhang H, Zeng G, Liang H, Wu Y, Zhou Y, Tian N, Wu A, Gao W, Wang X, Zhang X
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
Silibinin treatment protects human skin cells from UVB injury through upregulation of estrogen receptors.
Liu W, Wang F, Li C, Otkur W, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Onodera S, Ikejima T
Journal of photochemistry and photobiology. B, Biology 2021 Mar;216:112147
Journal of photochemistry and photobiology. B, Biology 2021 Mar;216:112147
ATF3 drives senescence by reconstructing accessible chromatin profiles.
Zhang C, Zhang X, Huang L, Guan Y, Huang X, Tian XL, Zhang L, Tao W
Aging cell 2021 Mar;20(3):e13315
Aging cell 2021 Mar;20(3):e13315
5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expression in TET2-Deficient Erythroleukemia Cells.
Reilly BM, Luger T, Park S, Lio CJ, González-Avalos E, Wheeler EC, Lee M, Williamson L, Tanaka T, Diep D, Zhang K, Huang Y, Rao A, Bejar R
Molecular cancer research : MCR 2021 Mar;19(3):451-464
Molecular cancer research : MCR 2021 Mar;19(3):451-464
Salubrinal Alleviates Collagen-Induced Arthritis through Promoting P65 Degradation in Osteoclastogenesis.
Wang Z, Li Z, Wang G, Sun Y, Yuan Y, Nie H
International journal of molecular sciences 2021 Mar 28;22(7)
International journal of molecular sciences 2021 Mar 28;22(7)
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Sun Y, He L, Wang W, Wang T, Hua W, Li T, Wang L, Gao T, Chen F, Tang L
Journal of ethnopharmacology 2021 Mar 25;268:113617
Journal of ethnopharmacology 2021 Mar 25;268:113617
Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways.
Guo C, Bi J, Li X, Lyu J, Liu X, Wu X, Liu J
Food chemistry 2021 Mar 15;340:127931
Food chemistry 2021 Mar 15;340:127931
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Feng J, Xie L, Yu X, Liu C, Dong H, Lu W, Kong R
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening.
Baxley RM, Leung W, Schmit MM, Matson JP, Yin L, Oram MK, Wang L, Taylor J, Hedberg J, Rogers CB, Harvey AJ, Basu D, Taylor JC, Pagnamenta AT, Dreau H, Craft J, Ormondroyd E, Watkins H, Hendrickson EA, Mace EM, Orange JS, Aihara H, Stewart GS, Blair E, Cook JG, Bielinsky AK
Nature communications 2021 Mar 12;12(1):1626
Nature communications 2021 Mar 12;12(1):1626
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Lu D, Le Y, Ding J, Dou X, Mao W, Zhu J
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus.
Chen L, Zhang J, Zou Y, Wang F, Li J, Sun F, Luo X, Zhang M, Guo Y, Yu Q, Yang P, Zhou Q, Chen Z, Zhang H, Gong Q, Zhao J, Eizirik DL, Zhou Z, Xiong F, Zhang S, Wang CY
Cell death and differentiation 2021 Jun;28(6):1880-1899
Cell death and differentiation 2021 Jun;28(6):1880-1899
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Li X, Wang X, Miao L, Liu Y, Lin X, Guo Y, Yuan R, Tian H
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Activation of yes-associated protein mediates sphingosine-1-phosphate-induced proliferation and migration of pulmonary artery smooth muscle cells and its potential mechanisms.
Shi W, Wang Q, Wang J, Yan X, Feng W, Zhang Q, Zhai C, Chai L, Li S, Xie X, Li M
Journal of cellular physiology 2021 Jun;236(6):4694-4708
Journal of cellular physiology 2021 Jun;236(6):4694-4708
miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.
Han S, Wang Z, Liu J, Wang HD, Yuan Q
Biochemical pharmacology 2021 Jun;188:114539
Biochemical pharmacology 2021 Jun;188:114539
T-17, a spirostanol saponin, inhibits p53-independent proliferation and p53-dependent migration of gastric cancer cells.
Xu J, Wang Y, Wang Z, Wang Y, He X
Steroids 2021 Jun;170:108828
Steroids 2021 Jun;170:108828
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
Hoshi M, Kubo H, Ando T, Tashita C, Nakamoto K, Yamamoto Y, Tezuka H, Saito K
ImmunoHorizons 2021 Jun 28;5(6):523-534
ImmunoHorizons 2021 Jun 28;5(6):523-534
SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells.
Xia S, Wu J, Zhou W, Zhang M, Zhao K, Liu J, Tian D, Liao J
Cell death & disease 2021 Jun 2;12(6):570
Cell death & disease 2021 Jun 2;12(6):570
Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells.
Liu Z, Zhu Q, Song E, Song Y
Toxicology 2021 Jun 15;457:152807
Toxicology 2021 Jun 15;457:152807
Particulate matter promotes hyperpigmentation via AhR/MAPK signaling activation and by increasing α-MSH paracrine levels in keratinocytes.
Shi Y, Zeng Z, Liu J, Pi Z, Zou P, Deng Q, Ma X, Qiao F, Xiong W, Zhou C, Zeng Q, Xiao R
Environmental pollution (Barking, Essex : 1987) 2021 Jun 1;278:116850
Environmental pollution (Barking, Essex : 1987) 2021 Jun 1;278:116850
YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.
Liu X, Chen D, Chen H, Wang W, Liu Y, Wang Y, Duan C, Ning Z, Guo X, Otkur W, Liu J, Qi H, Liu X, Lin A, Xia T, Liu HX, Piao HL
Cancer communications (London, England) 2021 Jul;41(7):576-595
Cancer communications (London, England) 2021 Jul;41(7):576-595
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Liu X, Li M, Zhu J, Huang W, Song J
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Human & experimental toxicology 2021 Jul;40(7):1095-1111
MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
Hu L, Yin C, Chen D, Wu Z, Liang S, Zhang Y, Huang Z, Liu S, Xu X, Chen Z, Zhang Y, Qian A
Cell death and differentiation 2021 Jul;28(7):2160-2178
Cell death and differentiation 2021 Jul;28(7):2160-2178
Fenofibrate inhibits TGF-β-induced myofibroblast differentiation and activation in human lung fibroblasts in vitro.
Kikuchi R, Maeda Y, Tsuji T, Yamaguchi K, Abe S, Nakamura H, Aoshiba K
FEBS open bio 2021 Jul 6;
FEBS open bio 2021 Jul 6;
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L.
Zhang W, Zhang R, Zeng Y, Li Y, Chen Y, Zhou J, Zhang Y, Wang A, Zhu J, Liu Z, Yan Z, Huang JA
Cell death & disease 2021 Jul 31;12(8):755
Cell death & disease 2021 Jul 31;12(8):755
C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation.
Ye L, Jia G, Li Y, Wang Y, Chen H, Yu L, Wu D
Journal of neuroinflammation 2021 Jul 18;18(1):159
Journal of neuroinflammation 2021 Jul 18;18(1):159
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Che J, Xu C, Wu Y, Jia P, Han Q, Ma Y, Wang X, Du Y, Zheng Y
Life sciences 2021 Jul 15;277:119520
Life sciences 2021 Jul 15;277:119520
Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling.
Cao YY, Wang ZH, Xu QC, Chen Q, Wang Z, Lu WH
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Jul 1;25(4):375-383
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Jul 1;25(4):375-383
Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways.
Li CH, Ma ZZ, Jian LL, Wang XY, Sun L, Liu XY, Yao ZQ, Zhao JX
International immunopharmacology 2021 Jan;90:107219
International immunopharmacology 2021 Jan;90:107219
Inhibition of miR-155 alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-κB signaling.
Cao YY, Wang Z, Wang ZH, Jiang XG, Lu WH
International immunopharmacology 2021 Jan;90:107218
International immunopharmacology 2021 Jan;90:107218
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Chen C, Gu J, Wang J, Wu Y, Yang A, Chen T, Zhou T, Liu Z
International immunopharmacology 2021 Jan;90:107206
International immunopharmacology 2021 Jan;90:107206
Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice.
Yang D, Xu D, Wang T, Yuan Z, Liu L, Shen Y, Wen F
International immunopharmacology 2021 Jan;90:107149
International immunopharmacology 2021 Jan;90:107149
Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.
Li X, Liu X, Deng R, Gao S, Jiang Q, Liu R, Li H, Miao Y, Zhai Y, Zhang S, Wang Z, Ren Y, Ning W, Zhou H, Yang C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153428
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153428
Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model.
Xu H, Qi Q, Yan X
Naunyn-Schmiedeberg's archives of pharmacology 2021 Jan;394(1):165-175
Naunyn-Schmiedeberg's archives of pharmacology 2021 Jan;394(1):165-175
Polychlorinated biphenyl quinone induced the acquisition of cancer stem cells properties and epithelial-mesenchymal transition through Wnt/β-catenin.
Qin Q, Yang B, Liu Z, Xu L, Song E, Song Y
Chemosphere 2021 Jan;263:128125
Chemosphere 2021 Jan;263:128125
Serotonin transporter regulation by cholesterol-independent lipid signaling.
Deveau CM, Rodriguez E, Schroering A, Yamamoto BK
Biochemical pharmacology 2021 Jan;183:114349
Biochemical pharmacology 2021 Jan;183:114349
P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.
Ji JZ, Li YF, Jiang LP, Tai T, Ge PX, Mi QY, Zhu T, Xie HG
Biochemical pharmacology 2021 Jan;183:114313
Biochemical pharmacology 2021 Jan;183:114313
Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma.
Jin J, Zhou M, Wang X, Liu M, Huang H, Yan F, Yu Z, Shu X, Huo X, Feng L, Zhang B, Huang S, Deng S, Wang C, Ma X
Fitoterapia 2021 Jan;148:104779
Fitoterapia 2021 Jan;148:104779
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway.
Liu K, Song J, Yan Y, Zou K, Che Y, Wang B, Li Z, Yu W, Guo W, Zou L, Deng W, Sun X
Translational oncology 2021 Jan;14(1):100876
Translational oncology 2021 Jan;14(1):100876
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
McKinzey DR, Gomathinayagam S, Griffin WC, Klinzing KN, Jeffries EP, Rajkovic A, Trakselis MA
The Journal of biological chemistry 2021 Jan-Jun;296:100355
The Journal of biological chemistry 2021 Jan-Jun;296:100355
NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway.
Yu S, Wang Y, Lv K, Hou J, Li W, Wang X, Guo H, Wang W
Technology in cancer research & treatment 2021 Jan-Dec;20:15330338211027916
Technology in cancer research & treatment 2021 Jan-Dec;20:15330338211027916
Localization of the WD repeat-containing protein 5 to the Virion Assembly Compartment Facilitates Human Cytomegalovirus Assembly.
Yang B, Yao Y, Wu H, Yang H, Ma XH, Li D, Wang XZ, Huang SN, Jiang X, Cheng S, Sun JY, Huang ZL, Zhao C, McVoy MA, Ahn JH, Zeng WB, Britt WJ, Gong S, Luo MH
Journal of virology 2021 Jan 27;
Journal of virology 2021 Jan 27;
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.
Zhang W, Yin G, Zhao H, Ling H, Xie Z, Xiao C, Chen Y, Lin Y, Jiang T, Jin S, Wang J, Yang X
Cell death & disease 2021 Jan 20;12(1):102
Cell death & disease 2021 Jan 20;12(1):102
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y
Life sciences 2021 Jan 15;265:118796
Life sciences 2021 Jan 15;265:118796
Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1.
Zong X, Xiao X, Kai L, Cheng Y, Fu J, Xu W, Wang Y, Zhao K, Jin M
International journal of biological macromolecules 2021 Jan 15;167:76-84
International journal of biological macromolecules 2021 Jan 15;167:76-84
Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1.
Kuan MI, Jaeger HK, Balemba OB, O'Dowd JM, Duricka D, Hannemann H, Marx E, Teissier N, Gabrielli L, Bonasoni MP, Keithley EM, Fortunato EA
Journal of virology 2021 Jan 13;95(3)
Journal of virology 2021 Jan 13;95(3)
Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells.
Zhao N, Dong W, Kim H, Moallemian R, Lv J, Wang H, Zheng H, Wei F, Ma X
Cellular signalling 2021 Feb;78:109848
Cellular signalling 2021 Feb;78:109848
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Li Y, Zhao Y, Li Y, Zhang X, Li C, Long N, Chen X, Bao L, Zhou J, Xie Y
Journal of physiology and biochemistry 2021 Feb;77(1):93-104
Journal of physiology and biochemistry 2021 Feb;77(1):93-104
Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response.
Roth LM, Zidane B, Festa L, Putatunda R, Romer M, Monnerie H, Jordan-Sciutto KL, Grinspan JB
Glia 2021 Feb;69(2):362-376
Glia 2021 Feb;69(2):362-376
The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
Ke W, Wang B, Hua W, Song Y, Lu S, Luo R, Li G, Wang K, Liao Z, Xiang Q, Li S, Wu X, Zhang Y, Yang C
Cell proliferation 2021 Feb;54(2):e12987
Cell proliferation 2021 Feb;54(2):e12987
LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior.
Naetar N, Georgiou K, Knapp C, Bronshtein I, Zier E, Fichtinger P, Dechat T, Garini Y, Foisner R
eLife 2021 Feb 19;10
eLife 2021 Feb 19;10
A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.
Noguchi T, Hidaka K, Kobayashi S, Matsumoto K, Yoshioka M, Hu X, Maloney DJ, Yang SM, Kato S
Drug development research 2021 Dec;82(8):1235-1246
Drug development research 2021 Dec;82(8):1235-1246
Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model.
Tanigawa S, Fujita M, Moyama C, Ando S, Ii H, Kojima Y, Fujishita T, Aoki M, Takeuchi H, Yamanaka T, Takahashi Y, Hashimoto N, Nakata S
Cancer gene therapy 2021 Dec;28(12):1339-1352
Cancer gene therapy 2021 Dec;28(12):1339-1352
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases.
Zhong S, Lian Y, Luo W, Luo R, Wu X, Ji J, Ji Y, Ding J, Wang X
Acta neuropathologica 2021 Dec;142(6):1003-1023
Acta neuropathologica 2021 Dec;142(6):1003-1023
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Zhang L, Zhu T, He F, Li X
International immunopharmacology 2021 Dec;101(Pt B):108238
International immunopharmacology 2021 Dec;101(Pt B):108238
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Zhu F, Shao J, Tian Y, Xu Z
International immunopharmacology 2021 Dec;101(Pt B):108221
International immunopharmacology 2021 Dec;101(Pt B):108221
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Cao P, Yang A, Li P, Xia X, Han Y, Zhou G, Wang R, Yang F, Li Y, Zhang Y, Cui Y, Ji H, Lu L, He F, Zhou G
Science advances 2021 Aug;7(35)
Science advances 2021 Aug;7(35)
Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP.
Zhang Q, Li W, Zhu Y, Wang Q, Zhai C, Shi W, Feng W, Wang J, Yan X, Chai L, Chen Y, Li C, Liu P, Li M
Molecular and cellular biochemistry 2021 Aug;476(8):3037-3049
Molecular and cellular biochemistry 2021 Aug;476(8):3037-3049
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Ma X, Zhang J, Wu Z, Wang X
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway.
Zhang H, Chi M, Chen L, Sun X, Wan L, Yang Q, Guo C
Phytotherapy research : PTR 2021 Aug;35(8):4363-4376
Phytotherapy research : PTR 2021 Aug;35(8):4363-4376
High-frequency near-infrared diode laser irradiation suppresses IL-1β-induced inflammatory cytokine expression and NF-κB signaling pathways in human primary chondrocytes.
Sakata S, Kunimatsu R, Tsuka Y, Nakatani A, Gunji H, Yanoshita M, Kado I, Ito S, Putranti NAR, Prasetya RC, Hirose N, Tanimoto K
Lasers in medical science 2021 Aug 7;
Lasers in medical science 2021 Aug 7;
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Li J, Wang S, Wang N, Zheng Y, Yang B, Wang X, Zhang J, Pan B, Wang Z
Cell communication and signaling : CCS 2021 Aug 30;19(1):89
Cell communication and signaling : CCS 2021 Aug 30;19(1):89
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
Zhu J, Ao H, Liu M, Cao K, Ma J
Journal of translational medicine 2021 Aug 30;19(1):374
Journal of translational medicine 2021 Aug 30;19(1):374
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Zhao Y, Lu J, Mao A, Zhang R, Guan S
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Repeated neonatal sevoflurane induced neurocognitive impairment through NF-κB-mediated pyroptosis.
Dai J, Li X, Wang C, Gu S, Dai L, Zhang J, Fan Y, Wu J
Journal of neuroinflammation 2021 Aug 21;18(1):180
Journal of neuroinflammation 2021 Aug 21;18(1):180
Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
Ge PX, Jiang LP, Tai T, Zhu T, Ji JZ, Li YF, Mi QY, Xie HG
Life sciences 2021 Aug 15;279:119268
Life sciences 2021 Aug 15;279:119268
KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer.
Lu D, Song Y, Yu Y, Wang D, Liu B, Chen L, Li X, Li Y, Cheng L, Lv F, Zhang P, Xing Y
Cell death & disease 2021 Aug 12;12(8):787
Cell death & disease 2021 Aug 12;12(8):787
Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice.
Tang XL, Wang X, Fang G, Zhao YL, Yan J, Zhou Z, Sun R, Luo AL, Li SY
The Journal of nutritional biochemistry 2021 Apr;90:108579
The Journal of nutritional biochemistry 2021 Apr;90:108579
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis.
Chibaatar E, Le K, Abdoulaye IA, Wu S, Guo Y
Journal of molecular neuroscience : MN 2021 Apr;71(4):691-701
Journal of molecular neuroscience : MN 2021 Apr;71(4):691-701
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway.
Du W, Zhu J, Zeng Y, Liu T, Zhang Y, Cai T, Fu Y, Zhang W, Zhang R, Liu Z, Huang JA
Cell death and differentiation 2021 Apr;28(4):1284-1300
Cell death and differentiation 2021 Apr;28(4):1284-1300
Myricetin protects against H2 O2 -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Kan X, Liu J, Chen Y, Guo W, Xu D, Cheng J, Cao Y, Yang Z, Fu S
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Journal of cellular physiology 2021 Apr;236(4):2684-2695
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L
Food & function 2021 Apr 7;12(7):3120-3131
Food & function 2021 Apr 7;12(7):3120-3131
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
Guo G, Gao M, Gao X, Zhu B, Huang J, Tu X, Kim W, Zhao F, Zhou Q, Zhu S, Wu Z, Yan Y, Zhang Y, Zeng X, Zhu Q, Yin P, Luo K, Sun J, Deng M, Lou Z
Nature communications 2021 Apr 12;12(1):2187
Nature communications 2021 Apr 12;12(1):2187
RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration.
Shao Z, Tu Z, Shi Y, Li S, Wu A, Wu Y, Tian N, Sun L, Pan Z, Chen L, Gao W, Zhou Y, Wang X, Zhang X
Frontiers in cell and developmental biology 2020;8:611234
Frontiers in cell and developmental biology 2020;8:611234
LncRNA AC010789.1 Promotes Colorectal Cancer Progression by Targeting MicroRNA-432-3p/ZEB1 Axis and the Wnt/β-Catenin Signaling Pathway.
Duan W, Kong X, Li J, Li P, Zhao Y, Liu T, Binang HB, Wang Y, Du L, Wang C
Frontiers in cell and developmental biology 2020;8:565355
Frontiers in cell and developmental biology 2020;8:565355
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, Chi T, Zou L, Wang S, He Z
Oxidative medicine and cellular longevity 2020;2020:7950457
Oxidative medicine and cellular longevity 2020;2020:7950457
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Tian TT, Li QR, Gan SQ, Chang CR, Shen XC
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats.
Yu J, Wang WN, Matei N, Li X, Pang JW, Mo J, Chen SP, Tang JP, Yan M, Zhang JH
Oxidative medicine and cellular longevity 2020;2020:4717258
Oxidative medicine and cellular longevity 2020;2020:4717258
Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.
Zavaczki E, Gáll T, Zarjou A, Hendrik Z, Potor L, Tóth CZ, Méhes G, Gyetvai Á, Agarwal A, Balla G, Balla J
Oxidative medicine and cellular longevity 2020;2020:3721383
Oxidative medicine and cellular longevity 2020;2020:3721383
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Du J, He W, Zhang C, Wu J, Li Z, Wang M, Feng S, Liang G
BioMed research international 2020;2020:3243906
BioMed research international 2020;2020:3243906
Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation.
Jin M, Feng H, Wang Y, Yan S, Shen B, Li Z, Qin H, Wang Q, Li J, Liu G
Oxidative medicine and cellular longevity 2020;2020:2940746
Oxidative medicine and cellular longevity 2020;2020:2940746
Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.
Bu W, Hao X, Yang T, Wang J, Liu Q, Zhang X, Li X, Gong Y, Shao C
Oxidative medicine and cellular longevity 2020;2020:2015920
Oxidative medicine and cellular longevity 2020;2020:2015920
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Wang H, Jiang Z, Pang Z, Zhou T, Gu Y
Drug design, development and therapy 2020;14:4801-4813
Drug design, development and therapy 2020;14:4801-4813
Reduced hydration-induced decreased caveolin-1 expression causes epithelial-to-mesenchymal transition.
Yang S, Zhao J, Huang S, Shu B, Yang R, Chen L, Xu Y, Xie J, Liu X, Jia J, Qi S
American journal of translational research 2020;12(12):8067-8083
American journal of translational research 2020;12(12):8067-8083
Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma.
Zhu G, Li X, Li J, Zhou W, Chen Z, Fan Y, Jiang Y, Zhao Y, Sun G, Mao W
Journal of Cancer 2020;11(22):6516-6529
Journal of Cancer 2020;11(22):6516-6529
Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo.
Wu Y, Wang Z, Lin Z, Fu X, Zhan J, Yu K
Frontiers in pharmacology 2020;11:682
Frontiers in pharmacology 2020;11:682
Linalool Prevents Cisplatin Induced Muscle Atrophy by Regulating IGF-1/Akt/FoxO Pathway.
Zhang H, Chi M, Chen L, Sun X, Wan L, Yang Q, Guo C
Frontiers in pharmacology 2020;11:598166
Frontiers in pharmacology 2020;11:598166
Repositioning an Immunomodulatory Drug Vidofludimus as a Farnesoid X Receptor Modulator With Therapeutic Effects on NAFLD.
Zhu Y, Xu S, Lu Y, Wei Y, Yao B, Guo F, Zheng X, Wang Y, He Y, Jin L, Li Y
Frontiers in pharmacology 2020;11:590
Frontiers in pharmacology 2020;11:590
Lycopene Exerts Neuroprotective Effects After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the Nuclear Factor Erythroid-2 Related Factor 2/Nuclear Factor-κ-Gene Binding Pathway.
Fu C, Zheng Y, Zhu J, Chen B, Lin W, Lin K, Zhu J, Chen S, Li P, Fu X, Lin Z
Frontiers in pharmacology 2020;11:585898
Frontiers in pharmacology 2020;11:585898
Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins.
Zhang X, Lin X, Qin C, Huang K, Sun X, Zhao L, Jin M
Frontiers in microbiology 2020;11:538355
Frontiers in microbiology 2020;11:538355
Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway.
Li X, Liu X, Deng R, Gao S, Yu H, Huang K, Jiang Q, Liu R, Li X, Zhang L, Zhou H, Yang C
Frontiers in pharmacology 2020;11:310
Frontiers in pharmacology 2020;11:310
Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication.
Li C, Wang L, Liu J, Yu Y, Huang Y, Huang X, Wei J, Qin Q
Frontiers in microbiology 2020;11:1446
Frontiers in microbiology 2020;11:1446
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma.
Xu H, Wang H, Zhao W, Fu S, Li Y, Ni W, Xin Y, Li W, Yang C, Bai Y, Zhan M, Lu L
Theranostics 2020;10(13):5671-5686
Theranostics 2020;10(13):5671-5686
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
Wu Y, Wang Z, Fu X, Lin Z, Yu K
International immunopharmacology 2020 Sep;86:106713
International immunopharmacology 2020 Sep;86:106713
ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3.
Li YL, Wu LW, Zeng LH, Zhang ZY, Wang W, Zhang C, Lin NM
Oncogene 2020 Sep;39(39):6203-6217
Oncogene 2020 Sep;39(39):6203-6217
Tacrolimus ameliorates tubulointerstitial inflammation in diabetic nephropathy via inhibiting the NFATc1/TRPC6 pathway.
Zhang S, Wang H, Liu Y, Yang W, Liu J, Han Y, Liu Y, Liu F, Sun L, Xiao L
Journal of cellular and molecular medicine 2020 Sep;24(17):9810-9824
Journal of cellular and molecular medicine 2020 Sep;24(17):9810-9824
Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.
Zhou Y, Han C, Wang E, Lorch AH, Serafin V, Cho BK, Gutierrez Diaz BT, Calvo J, Fang C, Khodadadi-Jamayran A, Tabaglio T, Marier C, Kuchmiy A, Sun L, Yacu G, Filip SK, Jin Q, Takahashi YH, Amici DR, Rendleman EJ, Rawat R, Bresolin S, Paganin M, Zhang C, Li H, Kandela I, Politanska Y, Abdala-Valencia H, Mendillo ML, Zhu P, Palhais B, Van Vlierberghe P, Taghon T, Aifantis I, Goo YA, Guccione E, Heguy A, Tsirigos A, Wee KB, Mishra RK, Pflumio F, Accordi B, Basso G, Ntziachristos P
Cancer discovery 2020 Sep;10(9):1388-1409
Cancer discovery 2020 Sep;10(9):1388-1409
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Sivalingam K, Samikkannu T
Brain sciences 2020 Sep 5;10(9)
Brain sciences 2020 Sep 5;10(9)
Circular RNA GLIS2 promotes colorectal cancer cell motility via activation of the NF-κB pathway.
Chen J, Yang X, Liu R, Wen C, Wang H, Huang L, Li W, Zhu Z, Zhu Y, Liu H
Cell death & disease 2020 Sep 23;11(9):788
Cell death & disease 2020 Sep 23;11(9):788
Facile Cholesterol Loading with a New Probe ezFlux Allows for Streamlined Cholesterol Efflux Assays.
Ravodina AM, Badgeley MA, Rajagopalan S, Fedyukina DV, Maiseyeu A
ACS omega 2020 Sep 15;5(36):23289-23298
ACS omega 2020 Sep 15;5(36):23289-23298
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Zhang B, Yu D, Luo N, Yang C, Zhu Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.
Zhao L, Li R, Qiu JZ, Yu JB, Cao Y, Yuan RT
Molecular and cellular probes 2020 Oct;53:101577
Molecular and cellular probes 2020 Oct;53:101577
Down-regulation of exosomal miR-200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis.
Zhao C, Wang D, Wang X, Mao Y, Xu Z, Sun Y, Mei X, Song J, Shi W
Journal of cellular and molecular medicine 2020 Oct;24(20):12164-12175
Journal of cellular and molecular medicine 2020 Oct;24(20):12164-12175
RNA demethylase Alkbh5 is widely expressed in neurons and decreased during brain development.
Du T, Li G, Yang J, Ma K
Brain research bulletin 2020 Oct;163:150-159
Brain research bulletin 2020 Oct;163:150-159
Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation.
Han B, Wang K, Tu Y, Tan L, He C
Dose-response : a publication of International Hormesis Society 2020 Oct-Dec;18(4):1559325820939751
Dose-response : a publication of International Hormesis Society 2020 Oct-Dec;18(4):1559325820939751
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
Shao Z, Pan Z, Lin J, Zhao Q, Wang Y, Ni L, Feng S, Tian N, Wu Y, Sun L, Gao W, Zhou Y, Zhang X, Wang X
Aging 2020 Oct 7;12(19):19254-19272
Aging 2020 Oct 7;12(19):19254-19272
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
Zohud BA, Guo P, Zohud BA, Li F, Hao JJ, Shan X, Yu W, Guo W, Qin Y, Cai X
Cell death & disease 2020 Oct 20;11(10):879
Cell death & disease 2020 Oct 20;11(10):879
Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis.
Wang Y, Kong W, Wang L, Zhang T, Huang B, Meng J, Yang B, Xie Z, Zhou H
International journal of molecular sciences 2020 Oct 18;21(20)
International journal of molecular sciences 2020 Oct 18;21(20)
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Li Y, Wu J, Yu S, Zhu J, Zhou Y, Wang P, Li L, Zhao Y
Brain research 2020 Oct 15;1745:146948
Brain research 2020 Oct 15;1745:146948
Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production.
Zhang W, Xiong H, Pang J, Su Z, Lai L, Lin H, Jian B, He W, Yang H, Zheng Y
Toxicology letters 2020 Oct 1;331:1-10
Toxicology letters 2020 Oct 1;331:1-10
Aryl hydrocarbon receptor signaling activation in systemic sclerosis attenuates collagen production and is a potential antifibrotic target.
Shi Y, Tang B, Yu J, Luo Y, Xiao Y, Pi Z, Tang R, Wang Y, Kanekura T, Zeng Z, Xiao R
International immunopharmacology 2020 Nov;88:106886
International immunopharmacology 2020 Nov;88:106886
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Sun Y, He L, Wang T, Hua W, Qin H, Wang J, Wang L, Gu W, Li T, Li N, Liu X, Chen F, Tang L
Molecular neurobiology 2020 Nov;57(11):4628-4641
Molecular neurobiology 2020 Nov;57(11):4628-4641
Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.
Liu S, Gao Y, Zhang L, Yin Y, Zhang W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):14946-14959
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):14946-14959
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Lee DH, Park JS, Lee YS, Han J, Lee DK, Kwon SW, Han DH, Lee YH, Bae SH
Autophagy 2020 Nov;16(11):1949-1973
Autophagy 2020 Nov;16(11):1949-1973
Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence.
Isermann A, Mann C, Rübe CE
International journal of molecular sciences 2020 Nov 30;21(23)
International journal of molecular sciences 2020 Nov 30;21(23)
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Ding S, Ma N, Liu H, Tang M, Mei J
Aging 2020 Nov 24;12(24):25505-25527
Aging 2020 Nov 24;12(24):25505-25527
Pin1 promotes pancreatic cancer progression and metastasis by activation of NF-κB-IL-18 feedback loop.
Sun Q, Fan G, Zhuo Q, Dai W, Ye Z, Ji S, Xu W, Liu W, Hu Q, Zhang Z, Liu M, Yu X, Xu X, Qin Y
Cell proliferation 2020 May;53(5):e12816
Cell proliferation 2020 May;53(5):e12816
DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.
Luo W, Zhang H, Liang X, Xia R, Deng H, Yi Q, Lv L, Qian L
Oncology reports 2020 May;43(5):1692-1704
Oncology reports 2020 May;43(5):1692-1704
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
Yu YP, Cai LC, Wang XY, Cheng SY, Zhang DM, Jian WG, Wang TD, Yang JK, Yang KB, Zhang C
Cancer science 2020 May;111(5):1555-1566
Cancer science 2020 May;111(5):1555-1566
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
Cai Z, Zhang MX, Tang Z, Zhang Q, Ye J, Xiong TC, Zhang ZD, Zhong B
The Journal of experimental medicine 2020 May 4;217(5)
The Journal of experimental medicine 2020 May 4;217(5)
Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/ Polyps with Dysplasia.
Fujiwara-Tani R, Fujii K, Mori S, Kishi S, Sasaki T, Ohmori H, Nakashima C, Kawahara I, Nishiguchi Y, Mori T, Sho M, Kondoh M, Luo Y, Kuniyasu H
International journal of molecular sciences 2020 May 28;21(11)
International journal of molecular sciences 2020 May 28;21(11)
Regulation of a PRMT5/NF-κB Axis by Phosphorylation of PRMT5 at Serine 15 in Colorectal Cancer.
Hartley AV, Wang B, Jiang G, Wei H, Sun M, Prabhu L, Martin M, Safa A, Sun S, Liu Y, Lu T
International journal of molecular sciences 2020 May 23;21(10)
International journal of molecular sciences 2020 May 23;21(10)
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
Huang H, Cai H, Zhang L, Hua Z, Shi J, Wei Y
International immunopharmacology 2020 Mar;80:106123
International immunopharmacology 2020 Mar;80:106123
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Cell proliferation 2020 Mar;53(3):e12779
Cell proliferation 2020 Mar;53(3):e12779
AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics.
Qi M, Dai D, Liu J, Li Z, Liang P, Wang Y, Cheng L, Zhan Y, An Z, Song Y, Yang Y, Yan X, Xiao H, Shao H
Oncogene 2020 Mar;39(13):2707-2723
Oncogene 2020 Mar;39(13):2707-2723
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Li ST, Huang, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X, Zhang H, Gao P
Nature metabolism 2020 Mar;2(3):256-269
Nature metabolism 2020 Mar;2(3):256-269
Nuclear-localized costimulatory molecule 4-1BBL promotes colon cancer cell proliferation and migration by regulating nuclear Gsk3β, and is linked to the poor outcomes associated with colon cancer.
Ge Y, Chen W, Zhang X, Wang H, Cui J, Liu Y, Ju S, Tian X, Ju S
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):577-591
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):577-591
Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression.
Shanley KL, Hu CL, Bizzozero OA
Journal of neurochemistry 2020 Mar;152(5):585-601
Journal of neurochemistry 2020 Mar;152(5):585-601
[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].
Wu CF, Xiao M, Wang YL, Threadgill MD, Li M, Tang Y, Lin X, Yang L, Li QS, Li X
Molekuliarnaia biologiia 2020 Mar-Apr;54(2):252-261
Molekuliarnaia biologiia 2020 Mar-Apr;54(2):252-261
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Zuo Y, Feng Q, Jin L, Huang F, Miao Y, Liu J, Xu Y, Chen X, Zhang H, Guo T, Yuan Y, Zhang L, Wang J, Zheng H
Nature communications 2020 Mar 2;11(1):1146
Nature communications 2020 Mar 2;11(1):1146
Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin.
Le K, Wu S, Chibaatar E, Ali AI, Guo Y
ACS chemical neuroscience 2020 Mar 18;11(6):979-993
ACS chemical neuroscience 2020 Mar 18;11(6):979-993
AEBP1 Promotes the Occurrence and Development of Abdominal Aortic Aneurysm by Modulating Inflammation via the NF-κB Pathway.
Ren J, Han Y, Ren T, Fang H, Xu X, Lun Y, Jiang H, Xin S, Zhang J
Journal of atherosclerosis and thrombosis 2020 Mar 1;27(3):255-270
Journal of atherosclerosis and thrombosis 2020 Mar 1;27(3):255-270
1,25-Dihydroxyvitamin D attenuates diabetic cardiac autophagy and damage by vitamin D receptor-mediated suppression of FoxO1 translocation.
Guo X, Lin H, Liu J, Wang D, Li D, Jiang C, Tang Y, Wang J, Zhang T, Li Y, Yao P
The Journal of nutritional biochemistry 2020 Jun;80:108380
The Journal of nutritional biochemistry 2020 Jun;80:108380
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
Luo X, Li Y, Yang P, Chen Y, Wei L, Yu T, Xia J, Ruan XZ, Zhao L, Chen Y
EBioMedicine 2020 Jun;56:102797
EBioMedicine 2020 Jun;56:102797
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W
Aging cell 2020 Jun;19(6):e13163
Aging cell 2020 Jun;19(6):e13163
Novel role of ASH1L histone methyltransferase in anaplastic thyroid carcinoma.
Xu B, Qin T, Yu J, Giordano TJ, Sartor MA, Koenig RJ
The Journal of biological chemistry 2020 Jun 26;295(26):8834-8845
The Journal of biological chemistry 2020 Jun 26;295(26):8834-8845
RGS12 Is a Novel Critical NF-κB Activator in Inflammatory Arthritis.
Yuan G, Yang S, Ng A, Fu C, Oursler MJ, Xing L, Yang S
iScience 2020 Jun 26;23(6):101172
iScience 2020 Jun 26;23(6):101172
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
You R, Zhou W, Li Y, Zhang Y, Huang S, Jia Z, Zhang A
Clinical science (London, England : 1979) 2020 Jun 26;134(12):1357-1376
Clinical science (London, England : 1979) 2020 Jun 26;134(12):1357-1376
YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.
Cui Y, Li F, Xie Q, Zhao S, Guo T, Guo P, Hu S, Hao J, Tian C, Yu W, Li Z, Fang L, Zhao L, Chen M, Wu T, Gu C
Cell death & disease 2020 Jun 19;11(6):476
Cell death & disease 2020 Jun 19;11(6):476
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, Wu D, Ji X
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
SIRT2 suppresses expression of inflammatory factors via Hsp90-glucocorticoid receptor signalling.
Sun K, Wang X, Fang N, Xu A, Lin Y, Zhao X, Nazarali AJ, Ji S
Journal of cellular and molecular medicine 2020 Jul;24(13):7439-7450
Journal of cellular and molecular medicine 2020 Jul;24(13):7439-7450
The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
Zhong X, Feng L, Xu WH, Wu X, Ding YD, Zhou Y, Lei CQ, Shu HB
Cellular & molecular immunology 2020 Jul;17(7):741-752
Cellular & molecular immunology 2020 Jul;17(7):741-752
Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction.
Posta N, Csősz É, Oros M, Pethő D, Potor L, Kalló G, Hendrik Z, Sikura KÉ, Méhes G, Tóth C, Posta J, Balla G, Balla J
Laboratory investigation; a journal of technical methods and pathology 2020 Jul;100(7):986-1002
Laboratory investigation; a journal of technical methods and pathology 2020 Jul;100(7):986-1002
EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer.
Li Y, Liu J, Xiao Q, Tian R, Zhou Z, Gan Y, Li Y, Shu G, Yin G
Cell death & disease 2020 Jul 30;11(7):604
Cell death & disease 2020 Jul 30;11(7):604
Deficiency of microRNA-628-5p promotes the progression of gastric cancer by upregulating PIN1.
Chen Y, Wu Y, Yu S, Yang H, Wang X, Zhang Y, Zhu S, Jie M, Liu C, Li X, Zhou Y, Yang S, Yang Y
Cell death & disease 2020 Jul 23;11(7):559
Cell death & disease 2020 Jul 23;11(7):559
Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia.
Zhao X, Shi Y, Zhang D, Tong X, Sun Y, Xue X, Fu J
Life sciences 2020 Jul 1;252:117662
Life sciences 2020 Jul 1;252:117662
Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling.
Yen WC, Wu YH, Wu CC, Lin HR, Stern A, Chen SH, Shu JC, Tsun-Yee Chiu D
Redox biology 2020 Jan;28:101363
Redox biology 2020 Jan;28:101363
Poly (ADP-ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation-associated chemotherapy-induced autophagy in leukaemia cells.
Li Y, Xie J, Li X, Fang J
Oncology letters 2020 Jan;19(1):368-378
Oncology letters 2020 Jan;19(1):368-378
USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
Liu J, Jin L, Chen X, Yuan Y, Zuo Y, Miao Y, Feng Q, Zhang H, Huang F, Guo T, Zhang L, Zhu L, Qian F, Zhu C, Zheng H
PLoS pathogens 2020 Jan;16(1):e1008215
PLoS pathogens 2020 Jan;16(1):e1008215
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Park JS, Lee DH, Lee YS, Oh E, Bae KH, Oh KJ, Kim H, Bae SH
Autophagy 2020 Jan;16(1):86-105
Autophagy 2020 Jan;16(1):86-105
Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells.
Li GH, Li AL, Chen XM, Zhang LY, Wang T, Wang XN, Shen T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109669
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109669
The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry.
Wang G, Jiang L, Wang J, Zhang J, Kong F, Li Q, Yan Y, Huang S, Zhao Y, Liang L, Li J, Sun N, Hu Y, Shi W, Deng G, Chen P, Liu L, Zeng X, Tian G, Bu Z, Chen H, Li C
Journal of virology 2020 Jan 6;94(2)
Journal of virology 2020 Jan 6;94(2)
Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter.
Jiang W, Yan Y, Chen M, Luo G, Hao J, Pan J, Hu S, Guo P, Li W, Wang R, Zuo Y, Sun Y, Sui S, Yu W, Pan Z, Zou K, Zheng Z, Deng W, Wu X, Guo W
Aging 2020 Jan 6;12(1):611-627
Aging 2020 Jan 6;12(1):611-627
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
He X, Chen S, Li C, Ban J, Wei Y, He Y, Liu F, Chen Y, Chen J
Cells 2020 Jan 4;9(1)
Cells 2020 Jan 4;9(1)
Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas.
Nakashima C, Yamamoto K, Kishi S, Sasaki T, Ohmori H, Fujiwara-Tani R, Mori S, Kawahara I, Nishiguchi Y, Mori T, Kondoh M, Luo Y, Kirita T, Kuniyasu H
Oncotarget 2020 Jan 28;11(4):309-321
Oncotarget 2020 Jan 28;11(4):309-321
Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.
Burrus CJ, McKinstry SU, Kim N, Ozlu MI, Santoki AV, Fang FY, Ma A, Karadeniz YB, Worthington AK, Dragatsis I, Zeitlin S, Yin HH, Eroglu C
Cell reports 2020 Jan 21;30(3):642-657.e6
Cell reports 2020 Jan 21;30(3):642-657.e6
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Xu A, Yang Y, Shao Y, Wu M, Sun Y
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Xiao J, Li W, Zheng X, Qi L, Wang H, Zhang C, Wan X, Zheng Y, Zhong R, Zhou X, Lu Y, Li Z, Qiu Y, Liu C, Zhang F, Zhang Y, Xu X, Yang Z, Chen H, Zhai Q, Wei B, Wang H
Immunity 2020 Jan 14;52(1):109-122.e6
Immunity 2020 Jan 14;52(1):109-122.e6
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
He H, Xu C, Zheng L, Wang K, Jin M, Sun Y, Yue Z
Molecular medicine reports 2020 Feb;21(2):597-606
Molecular medicine reports 2020 Feb;21(2):597-606
Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease.
Sikura KÉ, Potor L, Szerafin T, Oros M, Nagy P, Méhes G, Hendrik Z, Zarjou A, Agarwal A, Posta N, Torregrossa R, Whiteman M, Fürtös I, Balla G, Balla J
British journal of pharmacology 2020 Feb;177(4):793-809
British journal of pharmacology 2020 Feb;177(4):793-809
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.
Ding XY, Hu HY, Huang KN, Wei RQ, Min J, Qi C, Tang H, Qin X
Cancer science 2020 Feb;111(2):489-501
Cancer science 2020 Feb;111(2):489-501
A DNAH17 missense variant causes flagella destabilization and asthenozoospermia.
Zhang B, Ma H, Khan T, Ma A, Li T, Zhang H, Gao J, Zhou J, Li Y, Yu C, Bao J, Ali A, Murtaza G, Yin H, Gao Q, Jiang X, Zhang F, Liu C, Khan I, Zubair M, Hussain HMJ, Khan R, Yousaf A, Yuan L, Lu Y, Xu X, Wang Y, Tao Q, Hao Q, Fang H, Cheng H, Zhang Y, Shi Q
The Journal of experimental medicine 2020 Feb 3;217(2)
The Journal of experimental medicine 2020 Feb 3;217(2)
UBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma.
Zhang GC, Yu XN, Sun JL, Xiong J, Yang YJ, Jiang XM, Zhu JM
Aging 2020 Feb 3;12(3):2373-2392
Aging 2020 Feb 3;12(3):2373-2392
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Life sciences 2020 Feb 15;243:117244
Life sciences 2020 Feb 15;243:117244
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
Wang Q, Shi W, Zhang Q, Feng W, Wang J, Zhai C, Yan X, Li M
Life sciences 2020 Feb 1;242:117159
Life sciences 2020 Feb 1;242:117159
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Lang L, Xu B, Yuan J, Li S, Lian S, Chen Y, Guo J, Yang H
International immunopharmacology 2020 Dec;89(Pt B):106908
International immunopharmacology 2020 Dec;89(Pt B):106908
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Zhang X, Feng J, Su S, Huang L
Pharmaceutical biology 2020 Dec;58(1):239-246
Pharmaceutical biology 2020 Dec;58(1):239-246
Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-κB pathway.
Yu T, Dong D, Guan J, Sun J, Guo M, Wang Q
Herz 2020 Dec;45(Suppl 1):130-138
Herz 2020 Dec;45(Suppl 1):130-138
Promotion of esophageal adenocarcinoma metastasis via Wnt/ß-catenin signal pathway by sorting nexins 3.
Pan B, Liu L, Hu X, Sun X, Zhu Y, Zhang T, Wei D, Guo Y, Shan J
Journal of gastroenterology and hepatology 2020 Dec;35(12):2131-2139
Journal of gastroenterology and hepatology 2020 Dec;35(12):2131-2139
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
Lee J, Park J, Kim JH, Lee G, Park TE, Yoon KJ, Kim YK, Lim C
PLoS biology 2020 Dec;18(12):e3001002
PLoS biology 2020 Dec;18(12):e3001002
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AWM, Akkermans JJLL, Wijdeven RHM, Janssen GMC, van Veelen PA, Neefjes J
Cell reports 2020 Dec 8;33(10):108475
Cell reports 2020 Dec 8;33(10):108475
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Yang T, Sun W, Duan YH, Sun YB, Ren YM, Hou WY, Tian MQ
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
Expressional Localization and Functionally Identifying an RNA Editing Enzyme BmADARa of the Silkworm Bombyx mori.
Ye C, Jiang S, Gong M, Min Q, Fan M, Gao J, Meng Y
Insects 2020 Aug 12;11(8)
Insects 2020 Aug 12;11(8)
GADD45G Interacts with E-cadherin to Suppress the Migration and Invasion of Esophageal Squamous Cell Carcinoma.
Li T, Xu L, Teng J, Ma Y, Liu W, Wang Y, Chi X, Shao S, Dong Y, Zhan Q, Liu X
Digestive diseases and sciences 2020 Apr;65(4):1032-1041
Digestive diseases and sciences 2020 Apr;65(4):1032-1041
Ribosome profiling analysis identified a KRAS-interacting microprotein that represses oncogenic signaling in hepatocellular carcinoma cells.
Xu W, Deng B, Lin P, Liu C, Li B, Huang Q, Zhou H, Yang J, Qu L
Science China. Life sciences 2020 Apr;63(4):529-542
Science China. Life sciences 2020 Apr;63(4):529-542
A novel Sprouty4-ERK1/2-Wnt/β-catenin regulatory loop in marrow stromal progenitor cells controls osteogenic and adipogenic differentiation.
Tian L, Xiao H, Li M, Wu X, Xie Y, Zhou J, Zhang X, Wang B
Metabolism: clinical and experimental 2020 Apr;105:154189
Metabolism: clinical and experimental 2020 Apr;105:154189
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Wang Y, Yang Y, Zuo R, Wu J, Zhang C, Li C, Liu M, Zhou Y
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.
Ortega JA, Daley EL, Kour S, Samani M, Tellez L, Smith HS, Hall EA, Esengul YT, Tsai YH, Gendron TF, Donnelly CJ, Siddique T, Savas JN, Pandey UB, Kiskinis E
Neuron 2020 Apr 8;106(1):90-107.e13
Neuron 2020 Apr 8;106(1):90-107.e13
SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia.
Kong Q, Li Y, Liang Q, Xie J, Li X, Fang J
Cancer biology & therapy 2020 Apr 2;21(4):320-331
Cancer biology & therapy 2020 Apr 2;21(4):320-331
Interleukin-17 suppresses grass carp reovirus infection in Ctenopharyngodon idellus kidney cells by activating NF-κB signaling.
Zhang Y, Zhang X, Liang Z, Dai K, Zhu M, Zhang M, Pan J, Xue R, Cao G, Tang J, Song X, Hu X, Gong C
Aquaculture (Amsterdam, Netherlands) 2020 Apr 15;520:734969
Aquaculture (Amsterdam, Netherlands) 2020 Apr 15;520:734969
Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.
Xu X, Wang D, Zheng C, Gao B, Fan J, Cheng P, Liu B, Yang L, Luo Z
Theranostics 2019;9(8):2252-2267
Theranostics 2019;9(8):2252-2267
p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma.
Yang PM, Hong YH, Hsu KC, Liu TP
American journal of cancer research 2019;9(10):2120-2139
American journal of cancer research 2019;9(10):2120-2139
Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats.
Li J, Liu Y, Liu B, Li F, Hu J, Wang Q, Li M, Lou S
Neural plasticity 2019;2019:7920540
Neural plasticity 2019;2019:7920540
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z
Oxidative medicine and cellular longevity 2019;2019:6521218
Oxidative medicine and cellular longevity 2019;2019:6521218
Nuclear CD44 Mediated by Importin β Participated in Naïve Genes Transcriptional Regulation in C3A-iCSCs.
Su M, Wang P, Wang X, Zhang M, Wei S, Liu K, Han S, Han X, Deng Y, Shen L
International journal of biological sciences 2019;15(6):1252-1260
International journal of biological sciences 2019;15(6):1252-1260
Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes.
Trajkovic K, Valdez C, Ysselstein D, Krainc D
PloS one 2019;14(2):e0211727
PloS one 2019;14(2):e0211727
Revealing Antidepressant Mechanisms of Baicalin in Hypothalamus Through Systems Approaches in Corticosterone- Induced Depressed Mice.
Zhang K, He M, Wang F, Zhang H, Li Y, Yang J, Wu C
Frontiers in neuroscience 2019;13:834
Frontiers in neuroscience 2019;13:834
Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells.
Palikhe S, Ohashi W, Sakamoto T, Hattori K, Kawakami M, Andoh T, Yamazaki H, Hattori Y
Frontiers in pharmacology 2019;10:59
Frontiers in pharmacology 2019;10:59
The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster.
Mu F, Huang J, Xing T, Jing Y, Cui T, Guo Y, Yan X, Li H, Wang N
Frontiers in genetics 2019;10:525
Frontiers in genetics 2019;10:525
DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS.
Ruan J, Cao Y, Ling T, Li P, Wu S, Peng D, Wang Y, Jia X, Chen S, Xu A, Yuan S
Frontiers in immunology 2019;10:2202
Frontiers in immunology 2019;10:2202
Leptin-Induced Angiogenesis of EA.Hy926 Endothelial Cells via the Akt and Wnt Signaling Pathways In Vitro and In Vivo.
Yu F, Fu R, Liu L, Wang X, Wu T, Shen W, Gui Z, Mo X, Fang B, Xia L
Frontiers in pharmacology 2019;10:1275
Frontiers in pharmacology 2019;10:1275
Aerobic Exercise Improves Synaptic-Related Proteins of Diabetic Rats by Inhibiting FOXO1/NF-κB/NLRP3 Inflammatory Signaling Pathway and Ameliorating PI3K/Akt Insulin Signaling Pathway.
Wang Q, Hu J, Liu Y, Li J, Liu B, Li M, Lou S
Journal of molecular neuroscience : MN 2019 Sep;69(1):28-38
Journal of molecular neuroscience : MN 2019 Sep;69(1):28-38
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma.
Yang T, Zhou R, Yu S, Yu S, Cui Z, Hu P, Liu J, Qiao Q, Zhang J
Molecular and cellular biochemistry 2019 Sep;459(1-2):157-169
Molecular and cellular biochemistry 2019 Sep;459(1-2):157-169
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Li AL, Shen T, Wang T, Zhou MX, Wang B, Song JT, Zhang PL, Wang XL, Ren DM, Lou HX, Wang XN
Free radical biology & medicine 2019 Sep;141:21-33
Free radical biology & medicine 2019 Sep;141:21-33
A hidden human proteome encoded by 'non-coding' genes.
Lu S, Zhang J, Lian X, Sun L, Meng K, Chen Y, Sun Z, Yin X, Li Y, Zhao J, Wang T, Zhang G, He QY
Nucleic acids research 2019 Sep 5;47(15):8111-8125
Nucleic acids research 2019 Sep 5;47(15):8111-8125
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.
Yang J, Zhang L, Cao LL, Qi J, Li P, Wang XP, Sun XL
Cells 2019 Sep 13;8(9)
Cells 2019 Sep 13;8(9)
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Wu XY, Chen XM, Zhou MX, Hu HX, Zhang JZ, Wang XN, Ren DM, Lou HX, Shen T
Chemico-biological interactions 2019 Sep 1;310:108741
Chemico-biological interactions 2019 Sep 1;310:108741
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Le K, Chibaatar Daliv E, Wu S, Qian F, Ali AI, Yu D, Guo Y
International immunopharmacology 2019 Oct;75:105779
International immunopharmacology 2019 Oct;75:105779
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Tian S, Lei P, Teng C, Sun Y, Song X, Li B, Shan Y
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Molecular nutrition & food research 2019 Oct;63(20):e1900183
AEBP1, a prognostic indicator, promotes colon adenocarcinoma cell growth and metastasis through the NF-κB pathway.
Xing Y, Zhang Z, Chi F, Zhou Y, Ren S, Zhao Z, Zhu Y, Piao D
Molecular carcinogenesis 2019 Oct;58(10):1795-1808
Molecular carcinogenesis 2019 Oct;58(10):1795-1808
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Yang Q, Fan W, Zheng Z, Lin S, Liu C, Wang R, Li W, Zuo Y, Sun Y, Hu S, Chen M, Guo P, Pan J, Tian C, Zhu T, Diao C, Hao J, Yu W, Li L, Li Y, Guo W, Deng W, Wu X
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
Follicle-stimulating hormone promotes renal tubulointerstitial fibrosis in aging women via the AKT/GSK-3β/β-catenin pathway.
Zhang K, Kuang L, Xia F, Chen Y, Zhang W, Zhai H, Wang C, Wang N, Lu Y
Aging cell 2019 Oct;18(5):e12997
Aging cell 2019 Oct;18(5):e12997
Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury.
Zhong Y, Chen J, Chen J, Chen Y, Li L, Xie Y
Journal of neurochemistry 2019 Oct;151(2):166-184
Journal of neurochemistry 2019 Oct;151(2):166-184
P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus.
Cao L, Ji Y, Zeng L, Liu Q, Zhang Z, Guo S, Guo X, Tong Y, Zhao X, Li CM, Chen Y, Guo D
PLoS pathogens 2019 Oct;15(10):e1008079
PLoS pathogens 2019 Oct;15(10):e1008079
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
Arsenic trioxide inhibits angiogenesis in vitro and in vivo by upregulating FoxO3a.
Sun Z, Li M, Bai L, Fu J, Lu J, Wu M, Zhou C, Zhang Y, Wu Y
Toxicology letters 2019 Oct 15;315:1-8
Toxicology letters 2019 Oct 15;315:1-8
TMEM18 inhibits osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells by inactivating β-catenin.
Zhang Y, Wang H, Yin T, Liu Y, Zhou W, Fan X, Wu L, Song C, Shao J, Yang T
Experimental cell research 2019 Oct 1;383(1):111491
Experimental cell research 2019 Oct 1;383(1):111491
Type I collagen or gelatin stimulates mouse peritoneal macrophages to aggregate and produce pro-inflammatory molecules through upregulated ROS levels.
Zhang X, Chen YR, Zhao YL, Liu WW, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ogura T, Onodera S, Ikejima T
International immunopharmacology 2019 Nov;76:105845
International immunopharmacology 2019 Nov;76:105845
The protective effects of L-carnitine on myocardial ischaemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-κB pathway and the activation of Nrf2 pathway.
Li M, Xu S, Geng Y, Sun L, Wang R, Yan Y, Wang H, Li Y, Yi Q, Zhang Y, Hao J, Deng C, Li W, Xue L
Clinical and experimental pharmacology & physiology 2019 Nov;46(11):1001-1012
Clinical and experimental pharmacology & physiology 2019 Nov;46(11):1001-1012
Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism.
Yap JLY, Tai YK, Fröhlich J, Fong CHH, Yin JN, Foo ZL, Ramanan S, Beyer C, Toh SJ, Casarosa M, Bharathy N, Kala MP, Egli M, Taneja R, Lee CN, Franco-Obregón A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12853-12872
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12853-12872
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion.
Li Y, Feng D, Wang Z, Zhao Y, Sun R, Tian D, Liu D, Zhang F, Ning S, Yao J, Tian X
Cell death and differentiation 2019 Nov;26(11):2284-2299
Cell death and differentiation 2019 Nov;26(11):2284-2299
DYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild-type NSCLC cells to AZD9291.
Li YL, Ding K, Hu X, Wu LW, Zhou DM, Rao MJ, Lin NM, Zhang C
Journal of cellular and molecular medicine 2019 Nov;23(11):7427-7437
Journal of cellular and molecular medicine 2019 Nov;23(11):7427-7437
Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
Wang Y, Yuan S, Jia X, Ge Y, Ling T, Nie M, Lan X, Chen S, Xu A
Nature cell biology 2019 Nov;21(11):1346-1356
Nature cell biology 2019 Nov;21(11):1346-1356
Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway.
Yang L, Hong Q, Xu SG, Kuang XY, Di GH, Liu GY, Wu J, Shao ZM, Yu SJ
Molecular medicine reports 2019 Nov;20(5):4045-4258
Molecular medicine reports 2019 Nov;20(5):4045-4258
Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa B signaling pathway.
Liu L, Qu Y, Liu Y, Zhao H, Ma HC, Noor AF, Ji CJ, Nie L, Si M, Cheng L
Neural regeneration research 2019 Nov;14(11):1994-2002
Neural regeneration research 2019 Nov;14(11):1994-2002
ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma.
Liang B, Chen R, Song S, Wang H, Sun G, Yang H, Jing W, Zhou X, Fu Z, Huang G, Zhao J
Cell death & disease 2019 Nov 4;10(11):830
Cell death & disease 2019 Nov 4;10(11):830
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
Wan W, Wang L, Chen X, Zhu S, Shang W, Xiao G, Zhang LK
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
Peroxisome proliferator activated receptor γ promotes mineralization and differentiation in cementoblasts via inhibiting Wnt/β-catenin signaling pathway.
Hu Y, Wang C, Ha S, Zhu N, Cao Z, Song Y
Journal of cellular biochemistry 2019 Nov 11;
Journal of cellular biochemistry 2019 Nov 11;
PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy.
Li Q, Li ZM, Sun SY, Wang LP, Wang PX, Guo Z, Yang HW, Ye JT, Lu J, Liu PQ
Acta pharmacologica Sinica 2019 May;40(5):589-598
Acta pharmacologica Sinica 2019 May;40(5):589-598
Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy.
Feng W, Wang J, Yan X, Zhai C, Shi W, Wang Q, Zhang Q, Li M
Naunyn-Schmiedeberg's archives of pharmacology 2019 May;392(5):605-613
Naunyn-Schmiedeberg's archives of pharmacology 2019 May;392(5):605-613
Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels.
Li N, Wang T, Li Z, Ye X, Deng B, Zhuo S, Yao P, Yang M, Mei H, Chen X, Zhu T, Chen S, Wang H, Wang J, Le Y
Cancer biology & medicine 2019 May;16(2):220-233
Cancer biology & medicine 2019 May;16(2):220-233
A cellular model for Wilson's disease using patient-derived induced pluripotent stem cells revealed aberrant β-catenin pathway during osteogenesis.
Liu J, Cui Y, Shi L, Luan J, Zhou X, Han J
Biochemical and biophysical research communications 2019 May 28;513(2):386-391
Biochemical and biophysical research communications 2019 May 28;513(2):386-391
Ginsenoside Rk3 ameliorates high-fat-diet/streptozocin induced type 2 diabetes mellitus in mice via the AMPK/Akt signaling pathway.
Liu Y, Deng J, Fan D
Food & function 2019 May 22;10(5):2538-2551
Food & function 2019 May 22;10(5):2538-2551
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Sodium ferulate protects against influenza virus infection by activation of the TLR7/9-MyD88-IRF7 signaling pathway and inhibition of the NF-κB signaling pathway.
Zhu Y, Shao Y, Qu X, Guo J, Yang J, Zhou Z, Wang S
Biochemical and biophysical research communications 2019 May 14;512(4):793-798
Biochemical and biophysical research communications 2019 May 14;512(4):793-798
Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.
Zhang Y, Chen Y, Zheng J, Wang J, Duan S, Zhang W, Yan X, Zhu X
Journal of molecular cell biology 2019 May 1;11(5):383-394
Journal of molecular cell biology 2019 May 1;11(5):383-394
Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation.
Han M, Zhao M, Cheng C, Huang Y, Han S, Li W, Tu X, Luo X, Yu X, Liu Y, Chen Q, Ren X, Wang QK, Ke T
Human mutation 2019 Mar;40(3):310-325
Human mutation 2019 Mar;40(3):310-325
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia.
Liu Y, Xue X, Zhang H, Che X, Luo J, Wang P, Xu J, Xing Z, Yuan L, Liu Y, Fu X, Su D, Sun S, Zhang H, Wu C, Yang J
Autophagy 2019 Mar;15(3):493-509
Autophagy 2019 Mar;15(3):493-509
Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence.
Xu X, Liu Q, Zhang C, Ren S, Xu L, Zhao Z, Dou H, Li P, Zhang X, Gong Y, Shao C
Cell death & disease 2019 Mar 25;10(4):282
Cell death & disease 2019 Mar 25;10(4):282
In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways.
Zhang C, Li C, Jia X, Wang K, Tu Y, Wang R, Liu K, Lu T, He C
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Park JS, Lee YS, Lee DH, Bae SH
Free radical biology & medicine 2019 Jun;137:143-157
Free radical biology & medicine 2019 Jun;137:143-157
Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis.
Yan Y, Qin D, Hu B, Zhang C, Liu S, Wu D, Huang W, Huang X, Wang L, Chen X, Zhang L
Molecular therapy. Nucleic acids 2019 Jun 7;16:494-504
Molecular therapy. Nucleic acids 2019 Jun 7;16:494-504
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells.
Chen MK, Peng CC, Maner RS, Zulkefli ND, Huang SM, Hsieh CL
Life sciences 2019 Jun 1;226:1-11
Life sciences 2019 Jun 1;226:1-11
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
Zhang W, Lu Y, Li X, Zhang J, Lin W, Zhang W, Zheng L, Li X
Journal of experimental & clinical cancer research : CR 2019 Jul 9;38(1):296
Journal of experimental & clinical cancer research : CR 2019 Jul 9;38(1):296
DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.
Li D, Fu S, Wu Z, Yang W, Ru Y, Shu H, Liu X, Zheng H
Journal of cell science 2019 Jul 24;133(5)
Journal of cell science 2019 Jul 24;133(5)
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells.
Zhang Q, Liu RX, Chan KW, Hu J, Zhang J, Wei L, Tan H, Yang X, Liu H
Journal of experimental & clinical cancer research : CR 2019 Jul 19;38(1):320
Journal of experimental & clinical cancer research : CR 2019 Jul 19;38(1):320
IL-1β receptor antagonist (IL-1Ra) combined with autophagy inducer (TAT-Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes.
Wang F, Liu J, Chen X, Zheng X, Qu N, Zhang B, Xia C
Arthritis research & therapy 2019 Jul 10;21(1):171
Arthritis research & therapy 2019 Jul 10;21(1):171
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Shan H, Li T, Zhang L, Yang R, Li Y, Zhang M, Dong Y, Zhou Y, Xu C, Yang B, Liang H, Gao X, Shan H
EBioMedicine 2019 Jan;39:59-68
EBioMedicine 2019 Jan;39:59-68
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, Luo O, Wang S, Wei J, Ding Y, Yu D
EBioMedicine 2019 Jan;39:239-254
EBioMedicine 2019 Jan;39:239-254
Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells.
Qi S, Zhang P, Ma M, Yao M, Wu J, Mäkilä E, Salonen J, Ruskoaho H, Xu Y, Santos HA, Zhang H
Small (Weinheim an der Bergstrasse, Germany) 2019 Jan;15(1):e1804332
Small (Weinheim an der Bergstrasse, Germany) 2019 Jan;15(1):e1804332
Attenuation of Atherosclerosis by Protocatechuic Acid via Inhibition of M1 and Promotion of M2 Macrophage Polarization.
Liu Y, Wang X, Pang J, Zhang H, Luo J, Qian X, Chen Q, Ling W
Journal of agricultural and food chemistry 2019 Jan 23;67(3):807-818
Journal of agricultural and food chemistry 2019 Jan 23;67(3):807-818
The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest.
Trendel J, Schwarzl T, Horos R, Prakash A, Bateman A, Hentze MW, Krijgsveld J
Cell 2019 Jan 10;176(1-2):391-403.e19
Cell 2019 Jan 10;176(1-2):391-403.e19
Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.
Li M, Wang S, Li X, Kou R, Wang Q, Wang X, Zhao N, Zeng T, Xie K
Toxicology research 2019 Jan 1;8(1):67-76
Toxicology research 2019 Jan 1;8(1):67-76
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.
Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutierrez-Diaz BT, Wang KK, Johnson MR, Volk AG, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, Abshiru NA, Hijiya N, Peirs S, Vandamme N, Berx G, Goosens S, Marshall SA, Rendleman EJ, Takahashi YH, Wang L, Rawat R, Bartom ET, Collings CK, Van Vlierberghe P, Strikoudis A, Kelly S, Ueberheide B, Mantis C, Kandela I, Bourquin JP, Bornhauser B, Serafin V, Bresolin S, Paganin M, Accordi B, Basso G, Kelleher NL, Weinstock J, Kumar S, Crispino JD, Shilatifard A, Ntziachristos P
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Jan 1;25(1):222-239
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Jan 1;25(1):222-239
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Xu L, Liu JT, Li K, Wang SY, Xu S
Life sciences 2019 Jan 1;216:140-146
Life sciences 2019 Jan 1;216:140-146
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Molecular nutrition & food research 2019 Feb;63(4):e1800795
JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model.
Liu Q, Xie W, Wang Y, Chen S, Han J, Wang L, Gui P, Wu Q
Laboratory investigation; a journal of technical methods and pathology 2019 Dec;99(12):1810-1821
Laboratory investigation; a journal of technical methods and pathology 2019 Dec;99(12):1810-1821
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y
Free radical biology & medicine 2019 Dec;145:146-160
Free radical biology & medicine 2019 Dec;145:146-160
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Wang J, Li L, Wang J, Song L, Tan N, Wang Z
Cells 2019 Dec 7;8(12)
Cells 2019 Dec 7;8(12)
Anacardic acid inhibits RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced bone loss in vivo.
Zhao K, Jia Y, Peng J, Pang C, Zhang T, Han W, Jiang J, Lu X, Zhu J, Qian Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9100-9115
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9100-9115
The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors.
Cao P, Luo WW, Li C, Tong Z, Zheng ZQ, Zhou L, Xiong Y, Li S
PLoS pathogens 2019 Aug;15(8):e1007983
PLoS pathogens 2019 Aug;15(8):e1007983
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia.
Yang X, Wang G, Cao T, Zhang L, Ma Y, Jiang S, Teng X, Sun X
The Journal of biological chemistry 2019 Aug 30;294(35):12921-12932
The Journal of biological chemistry 2019 Aug 30;294(35):12921-12932
Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling.
Diao H, Cheng N, Zhao Y, Xu H, Dong H, Thamm DH, Zhang D, Lin D
BMC veterinary research 2019 Aug 2;15(1):276
BMC veterinary research 2019 Aug 2;15(1):276
High-mobility group box 1 protein modulated proliferation and radioresistance in esophageal squamous cell carcinoma.
Di X, He G, Chen H, Zhu C, Qin Q, Yan J, Zhang X, Sun X
Journal of gastroenterology and hepatology 2019 Apr;34(4):728-735
Journal of gastroenterology and hepatology 2019 Apr;34(4):728-735
Knockdown of Golgi phosphoprotein 73 blocks the trafficking of matrix metalloproteinase-2 in hepatocellular carcinoma cells and inhibits cell invasion.
Liu Y, Zhang X, Zhou S, Shi J, Xu Y, He J, Lin F, Wei A, Zhou L, Chen Z
Journal of cellular and molecular medicine 2019 Apr;23(4):2399-2409
Journal of cellular and molecular medicine 2019 Apr;23(4):2399-2409
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Zhou X, Li W, Wang S, Zhang P, Wang Q, Xiao J, Zhang C, Zheng X, Xu X, Xue S, Hui L, Ji H, Wei B, Wang H
Cell reports 2019 Apr 23;27(4):1176-1189.e5
Cell reports 2019 Apr 23;27(4):1176-1189.e5
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner.
Qin Z, Xiang C, Zhong F, Liu Y, Dong Q, Li K, Shi W, Ding C, Qin L, He F
Journal of experimental & clinical cancer research : CR 2019 Apr 11;38(1):154
Journal of experimental & clinical cancer research : CR 2019 Apr 11;38(1):154
Glycyrrhizin Protects Mice Against Experimental Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1 (HMGB1) Expression and Neuronal HMGB1 Release.
Sun Y, Chen H, Dai J, Wan Z, Xiong P, Xu Y, Han Z, Chai W, Gong F, Zheng F
Frontiers in immunology 2018;9:1518
Frontiers in immunology 2018;9:1518
An Immunosuppressive Tick Salivary Gland Protein DsCystatin Interferes With Toll-Like Receptor Signaling by Downregulating TRAF6.
Sun T, Wang F, Pan W, Wu Q, Wang J, Dai J
Frontiers in immunology 2018;9:1245
Frontiers in immunology 2018;9:1245
Overexpression of β-Catenin Decreases the Radiosensitivity of Human Nasopharyngeal Carcinoma CNE-2 Cells.
He H, Lin K, Su Y, Lin S, Zou C, Pan J, Zhou Y, Chen C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1929-1944
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1929-1944
Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway.
Liu X, Zhu Q, Zhang M, Yin T, Xu R, Xiao W, Wu J, Deng B, Gao X, Gong W, Lu G, Ding Y
Oxidative medicine and cellular longevity 2018;2018:7161592
Oxidative medicine and cellular longevity 2018;2018:7161592
Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells.
Cui S, Men L, Li Y, Zhong Y, Yu S, Li F, Du J
Mediators of inflammation 2018;2018:1625414
Mediators of inflammation 2018;2018:1625414
Prostaglandin F2α Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Wang Y, Yan S, Xiao B, Zuo S, Zhang Q, Chen G, Yu Y, Chen D, Liu Q, Liu Y, Shen Y, Yu Y
Diabetes 2018 Sep;67(9):1748-1760
Diabetes 2018 Sep;67(9):1748-1760
Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets.
Nguyen A, Guedán A, Mousnier A, Swieboda D, Zhang Q, Horkai D, Le Novere N, Solari R, Wakelam MJO
Journal of lipid research 2018 Sep;59(9):1671-1684
Journal of lipid research 2018 Sep;59(9):1671-1684
IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3.
Jiang LQ, Xia T, Hu YH, Sun MS, Yan S, Lei CQ, Shu HB, Guo JH, Liu Y
Cellular & molecular immunology 2018 Sep;15(9):858-867
Cellular & molecular immunology 2018 Sep;15(9):858-867
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, Zhang XN, Guo Y, Lei CQ, Yang Q, Luo WW, Li S, Shu HB
Immunity 2018 Sep 18;49(3):438-448.e5
Immunity 2018 Sep 18;49(3):438-448.e5
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.
Wang Y, Wang Y, Liu Z, Dong W, Yang B, Xia X, Song E, Song Y
Chemical research in toxicology 2018 Sep 17;31(9):954-963
Chemical research in toxicology 2018 Sep 17;31(9):954-963
Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus.
Wu CC, Jiang X, Wang XZ, Liu XJ, Li XJ, Yang B, Ye HQ, Harwardt T, Jiang M, Xia HM, Wang W, Britt WJ, Paulus C, Nevels M, Luo MH
Journal of virology 2018 Sep 1;92(17)
Journal of virology 2018 Sep 1;92(17)
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.
Zhai C, Shi W, Feng W, Zhu Y, Wang J, Li S, Yan X, Wang Q, Zhang Q, Chai L, Li C, Liu P, Li M
Life sciences 2018 Sep 1;208:87-95
Life sciences 2018 Sep 1;208:87-95
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Astrocyte elevated gene-1 participates in the production of pro-inflammatory cytokines in dental pulp cells via NF-κB signalling pathway.
Wu H, He M, Yang R, Zuo Y, Bian Z
International endodontic journal 2018 Oct;51(10):1130-1138
International endodontic journal 2018 Oct;51(10):1130-1138
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Li Y, Chen Y, Qiu C, Ma X, Lei K, Cai G, Liang X, Liu J
Journal of cellular biochemistry 2018 Oct 30;
Journal of cellular biochemistry 2018 Oct 30;
Salvianolic Acid B-Alleviated Angiotensin II Induces Cardiac Fibrosis by Suppressing NF-κB Pathway In Vitro.
Wang C, Luo H, Xu Y, Tao L, Chang C, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2018 Oct 26;24:7654-7664
Medical science monitor : international medical journal of experimental and clinical research 2018 Oct 26;24:7654-7664
ERα is a negative regulator of PD-L1 gene transcription in breast cancer.
Liu L, Shen Y, Zhu X, Lv R, Li S, Zhang Z, Shi YG, Tan L
Biochemical and biophysical research communications 2018 Oct 20;505(1):157-161
Biochemical and biophysical research communications 2018 Oct 20;505(1):157-161
Dynamic changes of proteasome and protective effect of bortezomib, a proteasome inhibitor, in mice with acute pancreatitis.
Zhu Q, Lin X, Liu X, Hou T, Zhang M, Wang N, Chen W, Lu G, Gong W, Ding Y, Xiao W
Biochemical and biophysical research communications 2018 Oct 20;505(1):126-133
Biochemical and biophysical research communications 2018 Oct 20;505(1):126-133
TRPV2-induced Ca2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.
Bai H, Zhu H, Yan Q, Shen X, Lu X, Wang J, Li J, Chen L
Cell communication and signaling : CCS 2018 Oct 16;16(1):68
Cell communication and signaling : CCS 2018 Oct 16;16(1):68
PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.
Wang L, Li Z, Tan Y, Li Q, Yang H, Wang P, Lu J, Liu P
Molecular and cellular endocrinology 2018 Oct 15;474:137-150
Molecular and cellular endocrinology 2018 Oct 15;474:137-150
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.
Yoney A, Etoc F, Ruzo A, Carroll T, Metzger JJ, Martyn I, Li S, Kirst C, Siggia ED, Brivanlou AH
eLife 2018 Oct 12;7
eLife 2018 Oct 12;7
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
Li YR, Li GH, Zhou MX, Xiang L, Ren DM, Lou HX, Wang XN, Shen T
Bioorganic & medicinal chemistry 2018 Oct 1;26(18):5140-5150
Bioorganic & medicinal chemistry 2018 Oct 1;26(18):5140-5150
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation.
Shi W, Zhai C, Feng W, Wang J, Zhu Y, Li S, Wang Q, Zhang Q, Yan X, Chai L, Liu P, Chen Y, Li M
Life sciences 2018 Oct 1;210:140-149
Life sciences 2018 Oct 1;210:140-149
Redox-active trace metal-induced release of high mobility group box 1(HMGB1) and inflammatory cytokines in fibroblast-like synovial cells is Toll-like receptor 4 (TLR4) dependent.
Alsousi AA, Igwe OJ
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3847-3858
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3847-3858
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, Li F, Chen A, Huang S
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Zhang LM, Zhang J, Zhang Y, Wang L, Fei C, Yi ZW, Dong L
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
Tetrachlorobenzoquinone-Induced Nrf2 Confers Neuron-like PC12 Cells Resistance to Endoplasmic Reticulum Stress via Regulating Glutathione Synthesis and Protein Thiol Homeostasis.
Liu Z, Dong W, Yang B, Peng L, Xia X, Pu L, Zhang N, Song E, Song Y
Chemical research in toxicology 2018 Nov 19;31(11):1230-1239
Chemical research in toxicology 2018 Nov 19;31(11):1230-1239
Follicle-stimulating hormone enhances hepatic gluconeogenesis by GRK2-mediated AMPK hyperphosphorylation at Ser485 in mice.
Qi X, Guo Y, Song Y, Yu C, Zhao L, Fang L, Kong D, Zhao J, Gao L
Diabetologia 2018 May;61(5):1180-1192
Diabetologia 2018 May;61(5):1180-1192
Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways.
Li CH, Xu LL, Jian LL, Yu RH, Zhao JX, Sun L, Du GH, Liu XY
International immunopharmacology 2018 May;58:136-144
International immunopharmacology 2018 May;58:136-144
Folic acid supplementation repressed hypoxia-induced inflammatory response via ROS and JAK2/STAT3 pathway in human promyelomonocytic cells.
Ma J, Zhen X, Huang X, Jiang X
Nutrition research (New York, N.Y.) 2018 May;53:40-50
Nutrition research (New York, N.Y.) 2018 May;53:40-50
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Wang H, Chen Y, Guo J, Shan T, Deng K, Chen J, Cai L, Zhou H, Zhao Q, Jin S, Xia J
Scientific reports 2018 May 4;8(1):7080
Scientific reports 2018 May 4;8(1):7080
OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos.
Wang R, Li C, Qiao P, Xue Y, Zheng X, Chen H, Zeng X, Liu W, Boldogh I, Ba X
Cell death & disease 2018 May 24;9(6):628
Cell death & disease 2018 May 24;9(6):628
Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells.
Hong F, Wan L, Liu J, Huang K, Xiao Z, Zhang Y, Shi C
FEBS open bio 2018 Mar;8(3):406-415
FEBS open bio 2018 Mar;8(3):406-415
Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.
Tian S, Li B, Lei P, Yang X, Zhang X, Bao Y, Shan Y
Molecular nutrition & food research 2018 Mar;62(6):e1700737
Molecular nutrition & food research 2018 Mar;62(6):e1700737
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Exosomes from C2C12 myoblasts enhance osteogenic differentiation of MC3T3-E1 pre-osteoblasts by delivering miR-27a-3p.
Xu Q, Cui Y, Luan J, Zhou X, Li H, Han J
Biochemical and biophysical research communications 2018 Mar 25;498(1):32-37
Biochemical and biophysical research communications 2018 Mar 25;498(1):32-37
Calpain and JNK pathways participate in isoflurane - induced nucleus translocation of apoptosis-inducing factor in the brain of neonatal rats.
Han X, Liu C, Zhang K, Guo M, Shen Z, Liu Y, Zuo Z, Cao M, Li Y
Toxicology letters 2018 Mar 15;285:60-73
Toxicology letters 2018 Mar 15;285:60-73
Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling.
Yang Y, Qi Q, Wang Y, Shi Y, Yang W, Cen Y, Zhu E, Li X, Chen D, Wang B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun;32(6):3096-3107
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun;32(6):3096-3107
Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor.
Kai W, Yating S, Lin M, Kaiyong Y, Baojin H, Wu Y, Fangzhou Y, Yan C
Biochemical pharmacology 2018 Jun;152:153-164
Biochemical pharmacology 2018 Jun;152:153-164
Excessive endoplasmic reticulum stress and decreased neuroplasticity-associated proteins in prefrontal cortex of obese rats and the regulatory effects of aerobic exercise.
Li F, Liu BB, Cai M, Li JJ, Lou SJ
Brain research bulletin 2018 Jun;140:52-59
Brain research bulletin 2018 Jun;140:52-59
Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway.
Tao L, Li D, Liu H, Jiang F, Xu Y, Cao Y, Gao R, Chen G
Brain research bulletin 2018 Jun;140:154-161
Brain research bulletin 2018 Jun;140:154-161
Fam83h mutation inhibits the mineralization in ameloblasts by activating Wnt/β-catenin signaling pathway.
Yang M, Huang W, Yang F, Zhang T, Wang C, Song Y
Biochemical and biophysical research communications 2018 Jun 18;501(1):206-211
Biochemical and biophysical research communications 2018 Jun 18;501(1):206-211
Long noncoding RNA lncARSR promotes hepatic cholesterol biosynthesis via modulating Akt/SREBP-2/HMGCR pathway.
Huang J, Chen S, Cai D, Bian D, Wang F
Life sciences 2018 Jun 15;203:48-53
Life sciences 2018 Jun 15;203:48-53
An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness.
Galarza Torre A, Shaw JE, Wood A, Gilbert HTJ, Dobre O, Genever P, Brennan K, Richardson SM, Swift J
Scientific reports 2018 Jun 12;8(1):8981
Scientific reports 2018 Jun 12;8(1):8981
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW
The Journal of clinical investigation 2018 Jun 1;128(6):2281-2296
The Journal of clinical investigation 2018 Jun 1;128(6):2281-2296
Sub-lethal ultraviolet B irradiation and Poly I:C treatment synergistically induced apoptosis of HaCaT cells through NF-κB pathway.
Otkur W, Liu W, Wang J, Jia X, Huang D, Wang F, Hayashi T, Tashiro SI, Onodera S, Ikejima T
Molecular immunology 2018 Jul;99:19-29
Molecular immunology 2018 Jul;99:19-29
Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinoma.
Zhang S, Xie C, Li H, Zhang K, Li J, Wang X, Yin Z
Laboratory investigation; a journal of technical methods and pathology 2018 Jul;98(7):883-894
Laboratory investigation; a journal of technical methods and pathology 2018 Jul;98(7):883-894
Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation.
Zhang Y, Li A, Shi J, Fang Y, Gu C, Cai J, Lin C, Zhao L, Liu S
Cell death & disease 2018 Jul 3;9(7):749
Cell death & disease 2018 Jul 3;9(7):749
Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats.
Shi X, Zhao Y, Ding C, Wang Z, Ji A, Li Z, Feng D, Li Y, Gao D, Zhou J, Tian X, Yao J
Toxicology and applied pharmacology 2018 Jul 1;350:21-31
Toxicology and applied pharmacology 2018 Jul 1;350:21-31
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Shi A, Shi H, Wang Y, Liu X, Cheng Y, Li H, Zhao H, Wang S, Dong L
International immunopharmacology 2018 Jan;54:125-130
International immunopharmacology 2018 Jan;54:125-130
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
Activation of peroxisome proliferation-activated receptor-γ inhibits transforming growth factor-β1-induced airway smooth muscle cell proliferation by suppressing Smad-miR-21 signaling.
Liu L, Pan Y, Zhai C, Zhu Y, Ke R, Shi W, Wang J, Yan X, Su X, Song Y, Gao L, Li M
Journal of cellular physiology 2018 Jan;234(1):669-681
Journal of cellular physiology 2018 Jan;234(1):669-681
PTEN-L promotes type I interferon responses and antiviral immunity.
Cao Y, Wang H, Yang L, Zhang Z, Li C, Yuan X, Bu L, Chen L, Chen Y, Li CM, Guo D
Cellular & molecular immunology 2018 Jan;15(1):48-57
Cellular & molecular immunology 2018 Jan;15(1):48-57
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Luo W, Zhang J, Liang L, Wang G, Li Q, Zhu P, Zhou Y, Li J, Zhao Y, Sun N, Huang S, Zhou C, Chang Y, Cui P, Chen P, Jiang Y, Deng G, Bu Z, Li C, Jiang L, Chen H
PLoS pathogens 2018 Jan;14(1):e1006851
PLoS pathogens 2018 Jan;14(1):e1006851
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.
Hou Y, Wang Y, He Q, Li L, Xie H, Zhao Y, Zhao J
Behavioural brain research 2018 Jan 15;336:32-39
Behavioural brain research 2018 Jan 15;336:32-39
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
Liu M, Xu H, Zhang L, Zhang C, Yang L, Ma E, Liu L, Li Y
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
IRF1 up-regulates isg15 gene expression in dsRNA stimulation or CSFV infection by targeting nucleotides -487 to -325 in the 5' flanking region.
Li XQ, Li XN, Liang JJ, Cai XB, Tao Q, Li YX, Qin Q, Xu SP, Luo TR
Molecular immunology 2018 Feb;94:153-165
Molecular immunology 2018 Feb;94:153-165
Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway.
Shen Z, Ma Y, Ji Z, Hao Y, Yan X, Zhong Y, Tang X, Ren W
Lipids in health and disease 2018 Feb 9;17(1):26
Lipids in health and disease 2018 Feb 9;17(1):26
LINC01016 promotes the malignant phenotype of endometrial cancer cells by regulating the miR-302a-3p/miR-3130-3p/NFYA/SATB1 axis.
Pan X, Li D, Huo J, Kong F, Yang H, Ma X
Cell death & disease 2018 Feb 21;9(3):303
Cell death & disease 2018 Feb 21;9(3):303
The interactome and spatial redistribution feature of Ca2+ receptor protein calmodulin reveals a novel role in invadopodia-mediated invasion.
Li T, Yi L, Hai L, Ma H, Tao Z, Zhang C, Abeysekera IR, Zhao K, Yang Y, Wang W, Liu B, Yu S, Tong L, Liu P, Zhu M, Ren B, Lin Y, Zhang K, Cheng C, Huang Y, Yang X
Cell death & disease 2018 Feb 20;9(3):292
Cell death & disease 2018 Feb 20;9(3):292
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.
Li Y, Zhang Z, Chen J, Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G, Wong J, Xu GL, Wang Z, Wang H, Gao S, Zhu B
Nature 2018 Dec;564(7734):136-140
Nature 2018 Dec;564(7734):136-140
Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway.
Fang X, Liu Y, Lu J, Hong H, Yuan J, Zhang Y, Wang P, Liu P, Ye J
Naunyn-Schmiedeberg's archives of pharmacology 2018 Dec;391(12):1373-1385
Naunyn-Schmiedeberg's archives of pharmacology 2018 Dec;391(12):1373-1385
Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling.
Wang J, Qi H, Zhang X, Si W, Xu F, Hou T, Zhou H, Wang A, Li G, Liu Y, Fang Y, Piao HL, Liang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:724-733
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:724-733
PNMA1, regulated by miR-33a-5p, promotes proliferation and EMT in hepatocellular carcinoma by activating the Wnt/β-catenin pathway.
Liu P, Chen B, Gu Y, Liu Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:492-499
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:492-499
The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response.
Lellahi SM, Rosenlund IA, Hedberg A, Kiær LT, Mikkola I, Knutsen E, Perander M
The Journal of biological chemistry 2018 Dec 7;293(49):18965-18976
The Journal of biological chemistry 2018 Dec 7;293(49):18965-18976
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Hu M, Liu L, Yao W
Gene 2018 Dec 15;678:261-269
Gene 2018 Dec 15;678:261-269
Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells.
Tian YS, Chen KC, Zulkefli ND, Maner RS, Hsieh CL
Molecules (Basel, Switzerland) 2018 Dec 14;23(12)
Molecules (Basel, Switzerland) 2018 Dec 14;23(12)
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.
Chen X, Wu L, Li D, Xu Y, Zhang L, Niu K, Kong R, Gu J, Xu Z, Chen Z, Sun J
Cancer medicine 2018 Aug;7(8):3834-3847
Cancer medicine 2018 Aug;7(8):3834-3847
The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation.
Yan X, Lu J, Zou X, Zhang S, Cui Y, Zhou L, Liu F, Shan A, Lu J, Zheng M, Feng B, Zhang Y
The FEBS journal 2018 Aug;285(16):3041-3055
The FEBS journal 2018 Aug;285(16):3041-3055
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
Ke M, Dong J, Wang Y, Zhang J, Zhang M, Wu Z, Lv Y, Wu R
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway.
Li L, Huang W, Wang S, Sun K, Zhang W, Ding Y, Zhang L, Tumen B, Ji L, Liu C
Molecules (Basel, Switzerland) 2018 Aug 14;23(8)
Molecules (Basel, Switzerland) 2018 Aug 14;23(8)
Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration.
Harada A, Maehara K, Ono Y, Taguchi H, Yoshioka K, Kitajima Y, Xie Y, Sato Y, Iwasaki T, Nogami J, Okada S, Komatsu T, Semba Y, Takemoto T, Kimura H, Kurumizaka H, Ohkawa Y
Nature communications 2018 Apr 11;9(1):1400
Nature communications 2018 Apr 11;9(1):1400
TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3.
Sang Y, Li Y, Song L, Alvarez AA, Zhang W, Lv D, Tang J, Liu F, Chang Z, Hatakeyama S, Hu B, Cheng SY, Feng H
Cancer research 2018 Apr 1;78(7):1792-1804
Cancer research 2018 Apr 1;78(7):1792-1804
Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ.
Wang J, Yu Z, Wang C, Tian X, Huo X, Wang Y, Sun C, Feng L, Ma J, Zhang B, Yang Q, Ma X, Xu Y
American journal of cancer research 2017;7(6):1270-1284
American journal of cancer research 2017;7(6):1270-1284
Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.
Wu X, Zhu H, Yan J, Khan M, Yu X
BioMed research international 2017;2017:4734127
BioMed research international 2017;2017:4734127
Necrostatin-1 attenuates early brain injury after subarachnoid hemorrhage in rats by inhibiting necroptosis.
Chen F, Su X, Lin Z, Lin Y, Yu L, Cai J, Kang D, Hu L
Neuropsychiatric disease and treatment 2017;13:1771-1782
Neuropsychiatric disease and treatment 2017;13:1771-1782
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, Xu Y
OncoTargets and therapy 2017;10:5471-5482
OncoTargets and therapy 2017;10:5471-5482
CDKL1 promotes tumor proliferation and invasion in colorectal cancer.
Qin C, Ren L, Ji M, Lv S, Wei Y, Zhu D, Lin Q, Xu P, Chang W, Xu J
OncoTargets and therapy 2017;10:1613-1624
OncoTargets and therapy 2017;10:1613-1624
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Song Z, Shah SZA, Yang W, Dong H, Yang L, Zhou X, Zhao D
Frontiers in molecular neuroscience 2017;10:128
Frontiers in molecular neuroscience 2017;10:128
MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
Xie X, Li S, Zhu Y, Liu L, Pan Y, Wang J, Shi W, Song Y, Yang L, Gao L, Zang W, Li M
Cell and tissue research 2017 Sep;369(3):527-539
Cell and tissue research 2017 Sep;369(3):527-539
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling.
Song Z, Yang W, Zhou X, Yang L, Zhao D
Neuropharmacology 2017 Sep 1;123:332-348
Neuropharmacology 2017 Sep 1;123:332-348
Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.
Shrestha S, Zhu J, Wang Q, Du X, Liu F, Jiang J, Song J, Xing J, Sun D, Hou Q, Peng Y, Zhao J, Sun X, Song X
International journal of oncology 2017 Oct;51(4):1249-1260
International journal of oncology 2017 Oct;51(4):1249-1260
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.
Yan S, Wei X, Xu S, Sun H, Wang W, Liu L, Jiang X, Zhang Y, Che Y
Oncotarget 2017 Oct 6;8(46):80909-80922
Oncotarget 2017 Oct 6;8(46):80909-80922
Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats.
Bai J, Yu XJ, Liu KL, Wang FF, Jing GX, Li HB, Zhang Y, Huo CJ, Li X, Gao HL, Qi J, Kang YM
Toxicology and applied pharmacology 2017 Oct 15;333:100-109
Toxicology and applied pharmacology 2017 Oct 15;333:100-109
Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms.
Li F, Zhu Y, Wan Y, Xie X, Ke R, Zhai C, Pan Y, Yan X, Wang J, Shi W, Li M
European journal of pharmacology 2017 Nov 5;814:324-334
European journal of pharmacology 2017 Nov 5;814:324-334
Cooperative regulation of Gja1 expression by members of the AP-1 family cJun and cFos in TM3 Leydig and TM4 Sertoli cells.
Ghouili F, Martin LJ
Gene 2017 Nov 30;635:24-32
Gene 2017 Nov 30;635:24-32
2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.
Xu S, Liu J, Shi J, Wang Z, Ji L
Scientific reports 2017 Nov 28;7(1):16511
Scientific reports 2017 Nov 28;7(1):16511
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Ye J, Wei X, Shang Y, Pan Q, Yang M, Tian Y, He Y, Peng Z, Chen L, Chen W, Wang R
Oncogene 2017 Nov 16;36(46):6391-6407
Oncogene 2017 Nov 16;36(46):6391-6407
Overexpression of Rsf-1 correlates with poor survival and promotes invasion in non-small cell lung cancer.
Zhang X, Fu L, Xue D, Zhang X, Hao F, Xie L, He J, Gai J, Liu Y, Xu H, Li Q, Wang E
Virchows Archiv : an international journal of pathology 2017 May;470(5):553-560
Virchows Archiv : an international journal of pathology 2017 May;470(5):553-560
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Gong X, Yang Y, Huang L, Zhang Q, Wan RZ, Zhang P, Zhang B
International immunopharmacology 2017 May;46:124-132
International immunopharmacology 2017 May;46:124-132
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Gao Y, Li J, Xu X, Wang S, Yang Y, Zhou J, Zhang L, Zheng F, Li X, Wang B
International journal of obesity (2005) 2017 May;41(5):729-738
International journal of obesity (2005) 2017 May;41(5):729-738
E-Prostanoid 3 Receptor Mediates Sprouting Angiogenesis Through Suppression of the Protein Kinase A/β-Catenin/Notch Pathway.
Chen D, Tang J, Wan Q, Zhang J, Wang K, Shen Y, Yu Y
Arteriosclerosis, thrombosis, and vascular biology 2017 May;37(5):856-866
Arteriosclerosis, thrombosis, and vascular biology 2017 May;37(5):856-866
Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages.
Fang W, Bi D, Zheng R, Cai N, Xu H, Zhou R, Lu J, Wan M, Xu X
Scientific reports 2017 May 10;7(1):1663
Scientific reports 2017 May 10;7(1):1663
Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication.
Guedán A, Swieboda D, Charles M, Toussaint M, Johnston SL, Asfor A, Panjwani A, Tuthill TJ, Danahay H, Raynham T, Mousnier A, Solari R
Journal of virology 2017 May 1;91(9)
Journal of virology 2017 May 1;91(9)
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells.
Ma L, Sun P, Zhang JC, Zhang Q, Yao SL
International journal of molecular medicine 2017 Jul;40(1):31-38
International journal of molecular medicine 2017 Jul;40(1):31-38
Nrf2-Knockout Protects from Intestinal Injuries in C57BL/6J Mice Following Abdominal Irradiation with γ Rays.
Yang W, Sun Z, Yang B, Wang Q
International journal of molecular sciences 2017 Jul 31;18(8)
International journal of molecular sciences 2017 Jul 31;18(8)
Correction: Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, Jin N, Xie Z, Tan M, Lin SH, Geng M, Ding J, Huang M
The Journal of cell biology 2017 Jul 24;
The Journal of cell biology 2017 Jul 24;
Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells.
Li S, Pan Y, Ke R, Xie X, Zhai C, Shi W, Wang J, Yan X, Chai L, Wang Q, Zhang Q, Su X, Yang L, Gao L, Li M
Scientific reports 2017 Jul 20;7(1):6088
Scientific reports 2017 Jul 20;7(1):6088
The electrophilic character of quinones is essential for the suppression of Bach1.
Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y
Toxicology 2017 Jul 15;387:17-26
Toxicology 2017 Jul 15;387:17-26
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
Hu YH, Chen Q, Lu YX, Zhang JM, Lin C, Zhang F, Zhang WJ, Li XM, Zhang W, Li XN
Oncotarget 2017 Jul 11;8(28):46191-46203
Oncotarget 2017 Jul 11;8(28):46191-46203
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Hu YR, Ma H, Zou ZY, He K, Xiao YB, Wang Y, Feng M, Ye XL, Li XG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining.
Ly P, Teitz LS, Kim DH, Shoshani O, Skaletsky H, Fachinetti D, Page DC, Cleveland DW
Nature cell biology 2017 Jan;19(1):68-75
Nature cell biology 2017 Jan;19(1):68-75
Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer.
Zhong H, Xiao M, Zarkovic K, Zhu M, Sa R, Lu J, Tao Y, Chen Q, Xia L, Cheng S, Waeg G, Zarkovic N, Yin H
Free radical biology & medicine 2017 Jan;102:67-76
Free radical biology & medicine 2017 Jan;102:67-76
The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins.
You L, Liu H, Huang J, Xie W, Wei J, Ye X, Qian W
Oncotarget 2017 Jan 31;8(5):7777-7790
Oncotarget 2017 Jan 31;8(5):7777-7790
Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells.
Xie Q, Fan F, Wei W, Liu Y, Xu Z, Zhai L, Qi Y, Ye B, Zhang Y, Basu S, Zhao Z, Wu J, Xu P
Scientific reports 2017 Jan 23;7:41089
Scientific reports 2017 Jan 23;7:41089
Repression of YAP by NCTD disrupts NSCLC progression.
Guo J, Wu Y, Yang L, Du J, Gong K, Chen W, Dai J, Li X, Xi S
Oncotarget 2017 Jan 10;8(2):2307-2319
Oncotarget 2017 Jan 10;8(2):2307-2319
The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling.
Lai D, Gao J, Bi X, He H, Shi X, Weng S, Chen Y, Yang Y, Ye Y, Fu G
Journal of molecular medicine (Berlin, Germany) 2017 Feb;95(2):155-165
Journal of molecular medicine (Berlin, Germany) 2017 Feb;95(2):155-165
A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury.
Ren X, Li X, Jia L, Chen D, Hou H, Rui L, Zhao Y, Chen Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Feb;31(2):711-718
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Feb;31(2):711-718
Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, Jin N, Xie Z, Tan M, Lin SH, Geng M, Ding J, Huang M
The Journal of cell biology 2017 Feb;216(2):409-424
The Journal of cell biology 2017 Feb;216(2):409-424
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.
Lu Y, Xie S, Zhang W, Zhang C, Gao C, Sun Q, Cai Y, Xu Z, Xiao M, Xu Y, Huang X, Wu X, Liu W, Wang F, Kang Y, Zhou T
Cell research 2017 Dec;27(12):1422-1440
Cell research 2017 Dec;27(12):1422-1440
Respiratory Syncytial Virus Nonstructural Protein 1 Blocks Glucocorticoid Receptor Nuclear Translocation by Targeting IPO13 and May Account for Glucocorticoid Insensitivity.
Xie J, Long X, Gao L, Chen S, Zhao K, Li W, Zhou N, Zang N, Deng Y, Ren L, Wang L, Luo Z, Tu W, Zhao X, Fu Z, Xie X, Liu E
The Journal of infectious diseases 2017 Dec 27;217(1):35-46
The Journal of infectious diseases 2017 Dec 27;217(1):35-46
Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells.
Wei X, Ye J, Shang Y, Chen H, Liu S, Liu L, Wang R
Oncotarget 2017 Dec 12;8(65):109301-109318
Oncotarget 2017 Dec 12;8(65):109301-109318
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, Kong W, Kong W
Redox biology 2017 Aug;12:987-1003
Redox biology 2017 Aug;12:987-1003
Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.
Tian Y, Li Z, Shen B, Zhang Q, Feng H
International immunopharmacology 2017 Apr;45:148-155
International immunopharmacology 2017 Apr;45:148-155
Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.
Lu Y, Wan J, Yang Z, Lei X, Niu Q, Jiang L, Passtoors WM, Zang A, Fraering PC, Wu F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1382-1397
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1382-1397
Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.
Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal RS, Artates JW, Tabet R, Wheeler VC, Bang AG, Cleveland DW, Lagier-Tourenne C
Neuron 2017 Apr 5;94(1):48-57.e4
Neuron 2017 Apr 5;94(1):48-57.e4
Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma.
Huang W, Zhou W, Li C, Yang Y, Shang YK, Chen C, Zhang J, Yao R, Wang P, Wen W, Liu HQ, Wang L, Li X, Bian H, Chen ZN
Oncotarget 2017 Apr 18;8(16):26288-26297
Oncotarget 2017 Apr 18;8(16):26288-26297
The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.
Fu J, Xia X, Liu Z, Wang Y, Wang Y, Shi Q, Song X, Song E, Song Y
Toxicology 2017 Apr 15;381:39-50
Toxicology 2017 Apr 15;381:39-50
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Nie H, Xue X, Liu G, Guan G, Liu H, Sun L, Zhao L, Wang X, Chen Z
Free radical research 2016;50(11):1200-1213
Free radical research 2016;50(11):1200-1213
Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway.
Huang X, He Z, Jiang X, Hou M, Tang Z, Zhen X, Liang Y, Ma J
PloS one 2016;11(3):e0151553
PloS one 2016;11(3):e0151553
Toll-like receptor 2-mediated MAPKs and NF-κB activation requires the GNAO1-dependent pathway in human mast cells.
Jin M, Yu B, Zhang W, Zhang W, Xiao Z, Mao Z, Lai Y, Lin D, Ma Q, Pan E, Zhang Y, Yu Y
Integrative biology : quantitative biosciences from nano to macro 2016 Sep 12;8(9):968-75
Integrative biology : quantitative biosciences from nano to macro 2016 Sep 12;8(9):968-75
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M, Lee YH, Bae SH
Free radical biology & medicine 2016 Oct;99:520-532
Free radical biology & medicine 2016 Oct;99:520-532
The absence of p53 during Human Cytomegalovirus infection leads to decreased UL53 expression, disrupting UL50 localization to the inner nuclear membrane, and thereby inhibiting capsid nuclear egress.
Kuan MI, O'Dowd JM, Fortunato EA
Virology 2016 Oct;497:262-278
Virology 2016 Oct;497:262-278
Salusin-β contributes to vascular inflammation associated with pulmonary arterial hypertension in rats.
Xu T, Zhang Z, Liu T, Zhang W, Liu J, Wang W, Wang J
The Journal of thoracic and cardiovascular surgery 2016 Oct;152(4):1177-87
The Journal of thoracic and cardiovascular surgery 2016 Oct;152(4):1177-87
Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.
Wu J, Lu M, Li Y, Shang YK, Wang SJ, Meng Y, Wang Z, Li ZS, Chen H, Chen ZN, Bian H
Oncogene 2016 Oct 20;35(42):5468-5479
Oncogene 2016 Oct 20;35(42):5468-5479
P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.
Tome ME, Herndon JM, Schaefer CP, Jacobs LM, Zhang Y, Jarvis CK, Davis TP
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Nov;36(11):1913-1928
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Nov;36(11):1913-1928
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
Zhang LK, Xin QL, Zhu SL, Wan WW, Wang W, Xiao G
Journal of virology 2016 Nov 15;90(22):10259-10270
Journal of virology 2016 Nov 15;90(22):10259-10270
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Li S, Zhu M, Pan R, Fang T, Cao YY, Chen S, Zhao X, Lei CQ, Guo L, Chen Y, Li CM, Jokitalo E, Yin Y, Shu HB, Guo D
Nature immunology 2016 Mar;17(3):241-9
Nature immunology 2016 Mar;17(3):241-9
REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.
Song Z, Zhu T, Zhou X, Barrow P, Yang W, Cui Y, Yang L, Zhao D
Oncotarget 2016 Mar 15;7(11):12035-52
Oncotarget 2016 Mar 15;7(11):12035-52
AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation.
Han X, Tai H, Wang X, Wang Z, Zhou J, Wei X, Ding Y, Gong H, Mo C, Zhang J, Qin J, Ma Y, Huang N, Xiang R, Xiao H
Aging cell 2016 Jun;15(3):416-27
Aging cell 2016 Jun;15(3):416-27
Go is required for the release of IL-8 and TNF-α, but not degranulation in human mast cells.
Yu Y, Huang Z, Mao Z, Zhang Y, Jin M, Chen W, Zhang W, Yu B, Zhang W, Alaster Lau HY
European journal of pharmacology 2016 Jun 5;780:115-21
European journal of pharmacology 2016 Jun 5;780:115-21
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Wang G, Yao J, Li Z, Zu G, Feng D, Shan W, Li Y, Hu Y, Zhao Y, Tian X
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons.
Jiang P, Gan M, Yen SH, Moussaud S, McLean PJ, Dickson DW
Acta neuropathologica 2016 Jul;132(1):77-91
Acta neuropathologica 2016 Jul;132(1):77-91
Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.
Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, Qian L, Liu C, Guo T, Zhang L, Wang X, Qian G, Li L, Ge J, Dai J, Xiong S, Zheng H
PLoS pathogens 2016 Jul;12(7):e1005764
PLoS pathogens 2016 Jul;12(7):e1005764
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, Xu Y, Zhao Y, Wang C, Peng J
Nutrients 2016 Jul 8;8(7)
Nutrients 2016 Jul 8;8(7)
Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation.
Gama Sosa MA, De Gasperi R, Hof PR, Elder GA
Scientific reports 2016 Jul 22;6:30267
Scientific reports 2016 Jul 22;6:30267
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
Su C, Shi Q, Song X, Fu J, Liu Z, Wang Y, Wang Y, Xia X, Song E, Song Y
Toxicology 2016 Jul 1;363-364:48-57
Toxicology 2016 Jul 1;363-364:48-57
MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes.
Chen LT, Hu MM, Xu ZS, Liu Y, Shu HB
Journal of immunology (Baltimore, Md. : 1950) 2016 Jul 1;197(1):199-207
Journal of immunology (Baltimore, Md. : 1950) 2016 Jul 1;197(1):199-207
Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IκB/NF-κB signaling.
Fu J, Shi Q, Song X, Xia X, Su C, Liu Z, Song E, Song Y
Environmental toxicology and pharmacology 2016 Jan;41:241-50
Environmental toxicology and pharmacology 2016 Jan;41:241-50
PRELP (proline/arginine-rich end leucine-rich repeat protein) promotes osteoblastic differentiation of preosteoblastic MC3T3-E1 cells by regulating the β-catenin pathway.
Li H, Cui Y, Luan J, Zhang X, Li C, Zhou X, Shi L, Wang H, Han J
Biochemical and biophysical research communications 2016 Feb 12;470(3):558-562
Biochemical and biophysical research communications 2016 Feb 12;470(3):558-562
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
Shi H, Shi A, Dong L, Lu X, Wang Y, Zhao J, Dai F, Guo X
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways.
Yan T, Yu X, Sun X, Meng D, Jia JM
Fitoterapia 2016 Dec;115:37-45
Fitoterapia 2016 Dec;115:37-45
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Song X, Shi Q, Liu Z, Wang Y, Wang Y, Song E, Song Y
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.
Shao W, Machamer CE, Espenshade PJ
Journal of lipid research 2016 Aug;57(8):1564-73
Journal of lipid research 2016 Aug;57(8):1564-73
The E3 Ubiquitin Ligase c-Cbl Inhibits Microglia-Mediated CNS Inflammation by Regulating PI3K/Akt/NF-κB Pathway.
Dong L, Li YZ, An HT, Wang YL, Chen SH, Qian YJ, Wang K, Zhen JL, Fan Z, Gong XL, Zheng Y, Wang XM
CNS neuroscience & therapeutics 2016 Aug;22(8):661-9
CNS neuroscience & therapeutics 2016 Aug;22(8):661-9
Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein.
Zhang J, Huang F, Tan L, Bai C, Chen B, Liu J, Liang J, Liu C, Zhang S, Lu G, Chen Y, Zhang H
Journal of virology 2016 Apr;90(8):3966-3980
Journal of virology 2016 Apr;90(8):3966-3980
Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells.
He W, Ye X, Huang X, Lel W, You L, Wang L, Chen X, Qian W
International journal of oncology 2016 Apr;48(4):1710-20
International journal of oncology 2016 Apr;48(4):1710-20
A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha.
Gesson K, Rescheneder P, Skoruppa MP, von Haeseler A, Dechat T, Foisner R
Genome research 2016 Apr;26(4):462-73
Genome research 2016 Apr;26(4):462-73
Identification and characterization of an endoplasmic reticulum localization motif.
Nie YW, Wang M, Zhang P, Huan L, Liu DJ
Biochemical and biophysical research communications 2016 Apr 22;473(1):249-254
Biochemical and biophysical research communications 2016 Apr 22;473(1):249-254
Mechanistic Study of the Phytocompound, 2- β -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches.
Shiau JY, Yin SY, Chang SL, Hsu YJ, Chen KW, Kuo TF, Feng CS, Yang NS, Shyur LF, Yang WC, Wen TN
Evidence-based complementary and alternative medicine : eCAM 2015;2015:475610
Evidence-based complementary and alternative medicine : eCAM 2015;2015:475610
The Overexpression of IQGAP1 and β-Catenin Is Associated with Tumor Progression in Hepatocellular Carcinoma In Vitro and In Vivo.
Jin X, Liu Y, Liu J, Lu W, Liang Z, Zhang D, Liu G, Zhu H, Xu N, Liang S
PloS one 2015;10(8):e0133770
PloS one 2015;10(8):e0133770
Demethylzeylasteral (T-96) Treatment Ameliorates Mice Lupus Nephritis Accompanied by Inhibiting Activation of NF-κB Pathway.
Hu Q, Yang C, Wang Q, Zeng H, Qin W
PloS one 2015;10(7):e0133724
PloS one 2015;10(7):e0133724
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver.
Liu S, Jing F, Yu C, Gao L, Qin Y, Zhao J
PloS one 2015;10(5):e0124951
PloS one 2015;10(5):e0124951
miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.
He K, Tong D, Zhang S, Cai D, Wang L, Yang Y, Gao L, Chang S, Guo B, Song T, Li A, Huang C
International journal of oncology 2015 Oct;47(4):1528-36
International journal of oncology 2015 Oct;47(4):1528-36
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, Chen H, Lu B, Sun Z, Wu S, Yang S, Li X, Ye X, Song E, Song Y
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.
Zhu M, Fang T, Li S, Meng K, Guo D
Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 1;195(1):289-97
Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 1;195(1):289-97
Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma.
Wang F, Yang JL, Yu KK, Xu M, Xu YZ, Chen L, Lu YM, Fang HS, Wang XY, Hu ZQ, Li FF, Kan L, Luo J, Wang SY
Molecular cancer 2015 Jan 27;14:10
Molecular cancer 2015 Jan 27;14:10
Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells.
Mao Q, Xie Z, Wang X, Chen W, Ren M, Shang M, Lei H, Tian Y, Li S, Liang P, Chen T, Liang C, Xu J, Li X, Huang Y, Yu X
Parasitology research 2015 Feb;114(2):659-70
Parasitology research 2015 Feb;114(2):659-70
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
Shi Q, Song X, Fu J, Su C, Xia X, Song E, Song Y
International immunopharmacology 2015 Dec;29(2):722-729
International immunopharmacology 2015 Dec;29(2):722-729
The effects of focal adhesion kinase on the motility, proliferation and apoptosis of Caco2 and SMMC-7721 cells.
Gao N, He H, Xiao L, Gao X, Shi H, Wu Q, Xu N, Lei Y, Song X, Hou Y
Medical oncology (Northwood, London, England) 2015 Apr;32(4):125
Medical oncology (Northwood, London, England) 2015 Apr;32(4):125
WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis.
Qin L, Yin YT, Zheng FJ, Peng LX, Yang CF, Bao YN, Liang YY, Li XJ, Xiang YQ, Sun R, Li AH, Zou RH, Pei XQ, Huang BJ, Kang TB, Liao DF, Zeng YX, Williams BO, Qian CN
Oncotarget 2015 Apr 30;6(12):10239-52
Oncotarget 2015 Apr 30;6(12):10239-52
Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3.
Hu Y, Duan M, Liang S, Wang Y, Feng Y
Brain research 2015 Apr 24;1605:39-48
Brain research 2015 Apr 24;1605:39-48
CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDAC1-associated repression of C/EBPα.
Li D, Zhu H, Liang C, Li W, Xing G, Ma L, Ding L, Zhang Y, He F, Zhang L
Journal of molecular cell biology 2014 Oct;6(5):368-79
Journal of molecular cell biology 2014 Oct;6(5):368-79
Role of α-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis.
Xia X, Su C, Fu J, Zhang P, Jiang X, Xu D, Hu L, Song E, Song Y
International immunopharmacology 2014 Oct;22(2):293-302
International immunopharmacology 2014 Oct;22(2):293-302
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Xu D, Hu L, Su C, Xia X, Zhang P, Fu J, Wang W, Xu D, Du H, Hu Q, Song E, Song Y
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/β-catenin signaling pathway.
Hu TH, Yao Y, Yu S, Han LL, Wang WJ, Guo H, Tian T, Ruan ZP, Kang XM, Wang J, Wang SH, Nan KJ
Cancer letters 2014 Nov 28;354(2):417-26
Cancer letters 2014 Nov 28;354(2):417-26
Pao Pereira Extract Suppresses Castration-Resistant Prostate Cancer Cell Growth, Survival, and Invasion Through Inhibition of NFκB Signaling.
Chang C, Zhao W, Xie B, Deng Y, Han T, Cui Y, Dai Y, Zhang Z, Gao J, Guo H, Yan J
Integrative cancer therapies 2014 May;13(3):249-58
Integrative cancer therapies 2014 May;13(3):249-58
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB
The Journal of biological chemistry 2014 May 2;289(18):12876-85
The Journal of biological chemistry 2014 May 2;289(18):12876-85
Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro.
Li FF, Yi S, Wen L, He J, Yang LJ, Zhao J, Zhang BP, Cui GH, Chen Y
Acta pharmacologica Sinica 2014 Jun;35(6):806-13
Acta pharmacologica Sinica 2014 Jun;35(6):806-13
Vascular endothelial growth factor receptor-1 activation promotes migration and invasion of breast cancer cells through epithelial-mesenchymal transition.
Ning Q, Liu C, Hou L, Meng M, Zhang X, Luo M, Shao S, Zuo X, Zhao X
PloS one 2013;8(6):e65217
PloS one 2013;8(6):e65217
Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L.
Yang GD, Huang TJ, Peng LX, Yang CF, Liu RY, Huang HB, Chu QQ, Yang HJ, Huang JL, Zhu ZY, Qian CN, Huang BJ
PloS one 2013;8(10):e78355
PloS one 2013;8(10):e78355
Conditioned medium of Wnt/β-catenin signaling-activated olfactory ensheathing cells promotes synaptogenesis and neurite growth in vitro.
Yang Z, Wu Y, Zheng L, Zhang C, Yang J, Shi M, Feng D, Wu Z, Wang YZ
Cellular and molecular neurobiology 2013 Oct;33(7):983-90
Cellular and molecular neurobiology 2013 Oct;33(7):983-90
Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model.
Shan Y, Schoenfeld RA, Hayashi G, Napoli E, Akiyama T, Iodi Carstens M, Carstens EE, Pook MA, Cortopassi GA
Antioxidants & redox signaling 2013 Nov 1;19(13):1481-93
Antioxidants & redox signaling 2013 Nov 1;19(13):1481-93
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
Shi H, Dong L, Jiang J, Zhao J, Zhao G, Dang X, Lu X, Jia M
Toxicology 2013 Jan 7;303:107-14
Toxicology 2013 Jan 7;303:107-14
Adeno-associated virus Rep78 restricts adenovirus E1B55K-mediated p53 nuclear exportation.
Wang J, Li W, Wang R, Xue J, Chen J
Acta biochimica et biophysica Sinica 2013 Feb;45(2):135-40
Acta biochimica et biophysica Sinica 2013 Feb;45(2):135-40
Induction of apoptosis in infantile hemangioma endothelial cells by propranolol.
Tu JB, Ma RZ, Dong Q, Jiang F, Hu XY, Li QY, Pattar P, Zhang H
Experimental and therapeutic medicine 2013 Aug;6(2):574-578
Experimental and therapeutic medicine 2013 Aug;6(2):574-578
Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation.
Tu JB, Dong Q, Hu XY, Jiang F, Ma RZ, He LY, Yang ZQ
Journal of biochemical and molecular toxicology 2012 Sep;26(9):374-80
Journal of biochemical and molecular toxicology 2012 Sep;26(9):374-80
1,2,3,4,6-penta-O-galloyl-β-D-glucose protects PC12 Cells from MPP(+)-mediated cell death by inducing heme oxygenase-1 in an ERK- and Akt-dependent manner.
Chen H, Li H, Cao F, Zhen L, Bai J, Yuan S, Mei Y
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2012 Oct;32(5):737-745
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2012 Oct;32(5):737-745
Hypoxia increases CX3CR1 expression via HIF-1 and NF‑κB in androgen-independent prostate cancer cells.
Xiao LJ, Chen YY, Lin P, Zou HF, Lin F, Zhao LN, Li D, Guo L, Tang JB, Zheng XL, Yu XG
International journal of oncology 2012 Nov;41(5):1827-36
International journal of oncology 2012 Nov;41(5):1827-36
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W, Shu HB
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 17;109(29):11770-5
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 17;109(29):11770-5
Activation of the Wnt/β-catenin signaling pathway is associated with glial proliferation in the adult spinal cord of ALS transgenic mice.
Chen Y, Guan Y, Liu H, Wu X, Yu L, Wang S, Zhao C, Du H, Wang X
Biochemical and biophysical research communications 2012 Apr 6;420(2):397-403
Biochemical and biophysical research communications 2012 Apr 6;420(2):397-403
Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kappaB AND AP-1 through inhibition of MAPKS and AKT/IkappaBalpha signaling pathways in macrophages.
Yeh JL, Hsu JH, Hong YS, Wu JR, Liang JC, Wu BN, Chen IJ, Liou SF
International journal of immunopathology and pharmacology 2011 Apr-Jun;24(2):345-56
International journal of immunopathology and pharmacology 2011 Apr-Jun;24(2):345-56
KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways.
Yeh JL, Hsu JH, Wu PJ, Liou SF, Liu CP, Chen IJ, Wu BN, Dai ZK, Wu JR
British journal of pharmacology 2010 Mar;159(5):1151-60
British journal of pharmacology 2010 Mar;159(5):1151-60
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12987-1-AP(LMNB1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using LMNB1 antibody 12987-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-LMNB1 (IP:12987-1-AP, 3ug; Detection:12987-1-AP 1:1000) with HeLa cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 12987-1-AP(LMNB1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
