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- Antibody Data
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- References [1573]
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- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 12987-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12987-1-AP, RRID:AB_2136290
- Product name
- Lamin B1 antibody
- Antibody type
- Polyclonal
- Description
- Lamin B1 antibody (Cat. #12987-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 150ul
Submitted references Epithelial Gab1 Restricts Sepsis-Induced Intestinal Injury by Orchestrating TNF/NF-κB Axis.
PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment.
Periplogenin Suppresses Hepatocarcinogenesis by Inducing Cellular Senescence via the Activating FOXO1/P53 Signaling Pathway.
LDHA protects vascular endothelial cells from oxidative stress‑induced mitochondrial damage via HIF‑1α activation and glycolytic reprogramming.
BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer-Associated Fibroblasts Crosstalk.
Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol-Induced Intestinal Injury via Microbiota-Dependent and -Independent AHR Activation.
An HHEX/IKKα positive feedback loop promotes intestinal inflammation.
GGC repeat expansions within new open reading frames are translated into toxic polyglycine proteins in oculopharyngodistal myopathy.
Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity.
Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications.
Histatin-1 promotes bone regeneration by coordinating osteogenic and angiogenic responses in a sustained-release hydrogel system.
Crebanine protects against ovariectomy-induced bone loss by targeting Sirt1 to interfere with NF-κB acetylation and ROS activity.
Qiangjing Tablets modulate oxidative stress and endoplasmic reticulum stress through the PI3K/Akt/NRF-2 signaling axis and regulate gut microbiota in ornidazole-induced asthenozoospermia rats.
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development.
SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING.
Kukoamine B Inhibits EMT in Lung Adenocarcinoma Cells by Regulating Intracellular PD-L1-Mediated p65 Nuclear Translocation.
NOX1/4 drives hepatic iron and lipid dysregulation, redox imbalance, and inflammation in ethanol-fed mice.
ECM-Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling.
IL-3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury.
RUNX1 restrains STAT1-GITRL signaling to shape an immunosuppressive CRC microenvironment.
Myeloid-Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis.
CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma.
NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4.
Nitrogen cavitation enables rapid and high-yield preparation of functional cell-membrane-derived vesicles.
Prophylactic isoimperatorin protects against LPS-ALI via mTOR-dependent control of inflammation, oxidative stress and ferroptosis markers.
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Phosphoethanolamine cytidylyltransferase 2 exerts an anti-tumor role in clear cell renal cell carcinoma by modulating the hippo/YAP1 signaling pathway in a PPP2R1A-dependent manner.
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Baimaside, a flavonoid glycoside from Apocynum venetum, ameliorates sepsis by allosterically inhibiting NF-κB p50-mediated IL-6 transcription.
Polystyrene nanoplastics promote adipogenesis by stimulating nuclear translocation of PPARγ.
HIF-1α drives pyroptosis in extravillous trophoblasts by suppressing PPAR-γ to activate the NLRP3 inflammasome in RA-complicated pregnancy.
Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis.
Zinc deficiency exacerbates and supplementation attenuates early-stage obesity-related podocyte injury via Nrf2/HO-1-mediated pyroptosis.
Dimethyl fumarate alleviates oxidative stress and inflammation in noise-induced hearing loss by activating Nrf2/HO-1 signaling in cochlear hair cells.
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production.
6-Gingerol alleviates NNK-induced lung carcinogenesis by boosting antioxidation and reducing inflammation.
YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice.
Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis.
Ononin induces ferroptosis in colorectal cancer cells via the PI3K/AKT/Nrf2 pathway to enhance anti-cancer immunotherapy.
Structural characterization and multi-omics analysis of novel Saposhnikovia divaricata (Turcz.) Schischk acidic heteropolysaccharide alleviating acute liver injury.
Circadian Clock Dysfunction Exacerbate Autistic-Like Behaviour and Wnt/β-Catenin Signalling Dysregulation in ASD Mice and Treatment of Melatonin.
Eugenol attenuates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the Nrf2/GPX4 pathway.
Molecular-scale isotropic 3D super-resolution microscopy via interference localization.
A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer.
Early growth response 1 promotes RNA polymerase I-directed transcription and cancer growth by activating RRN3 expression.
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
STT3A-mediated FCN3 N-glycosylation promotes Treg cell activation to drive hepatocellular carcinoma progression via Wnt/β-catenin.
CDK5RAP3 Regulates Testosterone Production in Mouse Leydig Cells.
Sensitising PDAC to Gemcitabine by Suppressing NF-κB Pathway and Enhancing Apoptosis.
Epicatechin Gallate Ameliorates UVB-Induced Photoaging by Inhibiting p38α-Mediated Autophagy and Oxidative Stress.
The Taurine-Slc6a6 Axis Promotes Breast Cancer Progression by Alleviating Oxidative Stress and Accelerating Cell Cycle Progression.
Nuclear activities and interactome of the NS5 protein of Tick-Borne Encephalitis Virus.
Trichostatin A Influences Dendritic Cells' Functions by Regulating Glucose and Lipid Metabolism via PKM2.
CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity.
Targeting sorting nexin 3 to treat pulmonary fibrosis by dual modulating Wnt/β-catenin signaling.
Bioswitchable intracellular delivery of small activating RNA by tetrahedral framework nucleic acid: Application to p21-mediated anti-tumor therapy.
SBF-1 suppresses colorectal cancer cell growth via modulating cholesterol metabolic reprogramming.
Forsythoside B protects cartilage and subchondral bone in osteoarthritis by regulating the Nrf2/NF - κ B signaling pathway.
Piezo1 mediated scaffold-free rapid generation of self-mineralized bone organoids via activating Wnt signaling.
CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation.
Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini-chromosome maintenance complex and causes DNA damage.
A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening.
High-fat diet mediates the formation of nonalcoholic fatty liver by modulating the AhR/miR-132/SIRT1 axis.
Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy.
LncRNA AC098613.1 promotes acute myeloid leukemia cell differentiation through CDC5L/ADAP1/NRD1 axis.
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
ELK1 suppressed the progression of vascular dementia via modulating mTOR/CREB/YAP/TFEB signaling induced ferroptosis in hippocampal cells.
Dipsacoside B alleviates aflatoxin B1-induced liver injury in mice.
DNMT2 inhibits anaplastic thyroid cancer progression by downregulating 5'tiRNA(Gly-GCC) production.
Ganoderma lucidum Polysaccharide Potentiates mRNA-LNP Efficacy: Synergizing Oxidative Stress Mitigation with Innate Immune Modulation.
S-nitrosation in endothelium: different outcomes of NRF2 and GSNOR loss.
Fungal-Bacterial Crosstalk Modulates Glucocorticoid-Primed TLR2 Signaling in the Human Skin.
Gingerenone A ameliorates airway inflammation and remodeling in asthma by modulating the TLR4/MyD88/NF-κB pathway.
The circadian clock component PER2 deficiency aggravates airway epithelial remodeling through Wnt/β-catenin signaling pathway.
Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A.
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence.
HIF-1α/Netrin-4 Axis Mediates RIPC-Induced Angiogenesis and Neurogenesis After Ischemic Stroke.
Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor.
Emerging Alternaria Toxins Drive LX-2 Cells Transdifferentiation into Myofibroblasts for Liver Fibrosis and CotA Detoxification.
Esculetin inhibits PRV replication by suppressing activation of the PI3K-AKT/NF-κB pathway.
Peritoneal dialysis-induced senescence contributes to treatment failure in long-term PD.
Disruption of spike protein N-glycosylation induces its endoplasmic reticulum retention and attenuates SARS-CoV-2 infectivity.
Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation.
FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis.
ITLN1 suppresses colorectal cancer progression by inhibiting Wnt/β-catenin-mediated EMT and reprogramming macrophage polarization.
Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.
Regulation of PSAT1 and PHGDH by m6A in endocrine-resistant breast cancer cells.
Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens nuclear lamina and disrupts 14-3-3 proteins.
Chronic Psychological Stress Activates TRP/TAM/CXCL1 Signaling to Promote Breast Cancer Adipocyte Lipolysis via KEAP1 m(6)A Demethylation.
GPX4 predicts poor prognosis and regulates tumor proliferation and senescence in colorectal adenocarcinoma.
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation.
WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.
Inhibiting CXCR6 promotes senescence of activated hepatic stellate cells with limited proinflammatory SASP to attenuate hepatic fibrosis.
Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway.
ADAMTS7 Enhances Gastric Cancer Growth and Metastasis by Triggering the NF-κB Signaling Pathway.
GDF15 is associated with thyroid cancer progression and may modulate thyroid cancer cell senescence in a p53-dependent manner.
Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury.
Isoliensinine exerts antitumor effects in lung adenocarcinoma by inhibiting APEX1-driven ROS production.
Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway.
The TMBIM1-YBX1 axis orchestrates MDSC recruitment and immunosuppressive microenvironment in pancreatic cancer.
PPP1R12B inhibits cell proliferation by inducing G0/G1 phase arrest via PAK2/β-catenin axis in hepatocellular carcinoma.
Garlic oil-loaded nanodisks for the amelioration of acute lung injury via modulation of the NF-κB and Keap1-Nrf2 axis.
Suramin blocked hCAP18/LL-37-induced macrophage recruitment and M2 polarization to enhance the therapeutic efficacy of 1,25(OH)(2)D(3) against hepatocellular carcinoma in vitro and in vivo mouse model.
A novel glucomannan from Bletilla striata ameliorates colitis: Restores intestinal barrier, alleviates inflammation, and modulates the gut flora.
Congenital Hypothyroidism Dysregulates TRPC6 to Mediate Abnormal Dendritic Spine Growth of Hippocampal Neurons.
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription.
Age-Dependent Histone Deacetylase 3 Regulation by βA3/A1-Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age-Related Macular Degeneration.
Bioactive ROS-responsive nanotherapeutics attenuate intermittent hypoxia-induced cognitive impairment via NRF2/KEAP1/HO-1 signaling.
Downregulation of ANXA2 suppresses trophoblast cell invasion and migration through β-catenin pathway in preeclampsia.
Artemisitene Ameliorates Diabetic Wounds by Inhibiting Ferroptosis Through Activation of the Nrf2/GPX4 Pathway.
Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis-Mediated DNA Repair in Osteosarcoma.
A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage.
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.
CHD4 drives gastric cancer metastasis via MYH9/GSK3β/β-catenin axis and WNT/EMT pathway activation.
TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis.
Sheng Mai San Mitigates Heat Stress-Induced Myocardial Injury by Coordinated Regulation of the Keap1-Nrf2-HO-1 and Stub1-HSF1 Signaling Pathways.
Protective Effect of Hepcidin on Sepsis-Associated Acute Kidney Injury via Activating the Nrf2/GPX4 Signaling Pathway.
TGF-β(1) induces super-enhancers at the loci of the EMT-related genes in human keratinocyte HaCaT cells.
TRAF2 mediates Wnt-induced β-catenin nuclear translocation by associating with the nuclear pore complex.
African swine fever virus pNP419L inhibits type I interferon signaling by blocking ISGF3-mediated transcriptional activation.
Data-independent acquisition-based quantitative proteomic analysis of the effects of environmental enrichment on the dorsal roots of mice with neuropathic pain induced by chronic sciatic nerve constriction injury.
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.
Therapeutic targeting of Nrf2/HO-1/NF-κB signaling axis with casticin mitigates intervertebral disc degeneration: in vitro and in vivo investigations.
Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization.
BRPF1 inhibitor GSK6853 inhibits NSCLC cell proliferation via the JAK2/STAT3/CCNA2 axis to induce cell cycle arrest.
OGT-Mediated O-GlcNAcylation of ATF2 Protects Against Sepsis-Associated Encephalopathy by Inhibiting Microglial Pyroptosis.
Guanosine enhances thermogenesis and impairs KEAP1-mediated NRF2 degradation to resist ferroptosis in brown adipose tissue.
Galectin-3 gene deletion alters lipid profile in healthy and cardiomyopathy mouse hearts.
Acetyl-CoA Short-Chain Synthetase-2 Regulates Myocardial Ischemia/Reperfusion Injury by Targeting Histone Acetylation.
5-HT regulates resistance to aumolertinib by attenuating ferroptosis in lung adenocarcinoma.
The AKT-USP15 axis modulates autophagy in MPP(+)-induced Parkinson's disease model of SN4741 cells.
Forsythiaside A Suppresses Ferroptosis and Mitigates Type 2 Diabetes Osteoporosis Through the NRF2/GPX4 Axis.
Eimeria tenella aspartyl protease is identified as a potential TLR15 ligand and activates macrophages and dendritic cells in chickens.
Lycium barbarum Polysaccharides Suppress Radiation-Induced Microglial Inflammation by Inhibiting the IKKβ/IκBα/NF-κB Pathway.
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer.
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice.
Nuclei sense complex tissue shape and direct intestinal stem cell fate.
Pseudorabies virus DNA polymerase processivity factor pUL42 inhibits type I IFN production by negatively regulating cGAS-STING signaling pathway.
ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8-mediated SUMOylation of nonstructural protein 5.
Gamma-aminobutyric acid attenuates cortisol-induced damage in human colorectal adenocarcinoma cells via Nrf2 signaling.
Senescent fibroblasts modulate the radiation response of neighboring epithelial cells.
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming.
Epigenetic regulation by WTAPP1 promotes trophoblast dysfunction in gestational diabetes via CNR1/NF-κB activation.
Pediatric doxorubicin exposure induces persistent pathological changes in mice.
Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression.
Blockade of TGF-β1/Smad3 signaling pathway by Bovine Milk-derived extracellular vesicles ameliorates skin fibrosis in systemic sclerosis mice.
Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy.
Molecular mechanism of the crosstalk between glucocorticoid receptor (GR) and hypoxia-inducible factor 3α (HIF-3α) pathways.
Intranuclear paraspeckle-circular RNA TACC3 assembly forms RNA-DNA hybrids to facilitate MASH-related hepatocellular carcinoma growth in an m(6)A-dependent manner.
STN1 Shields CTC1 From TRIM32-Mediated Ubiquitination to Prevent Cellular Aging.
FBXW7 is a multifaceted regulator of the innate immune response to DNA viruses.
Amlodipine synergizes with temozolomide against glioma stem cells by modulating MGMT expression through downregulation of the AKT/GSK3β/β-catenin axis.
Discovery of a novel Genipin derivative targeting YB-1 to enhance the P-glycoprotein-mediated paclitaxel sensitivity of paclitaxel-resistant non-small cell lung cancer.
A serum-free adipose-conditioned medium delays stem cell senescence and maintains tissue homeostasis via IL-6/STAT3 axis suppression.
Botulinum Neurotoxin Type A Combined with Platelet-Rich Plasma Promotes Hair Follicle Growth and Regeneration via STMN1 Modulation and Wnt/β-Catenin Pathway Activation.
Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging.
The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression.
Dendrobine alleviates CCl(4)-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways.
Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD.
Tau impedes glioma progression by enhancing fatty acid β-oxidation-induced cellular senescence.
Up-regulation of Ifi27l2a expression in bone marrow monocytes contributes to glucocorticoid-induced bone loss.
CDC5L facilitates cardiomyocyte proliferation and ameliorates myocardial ischemia-reperfusion injury via modulation of the FGF10-YAP axis.
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
Leucokinin VIII acetate mitigates asthma severity by targeting ADCK5-induced cellular senescence.
DNAJC9 Binds to and Enhances the Transcription of Hepatitis B Virus cccDNA by Recruiting Histone H3.3.
Ursonic Acid Ameliorates H(2)O(2)-Induced Oxidative Damage in PC12 Cells and Prolonged the Lifespan in C. elegans by Activating MAPKs/Nrf2/HO-1 Signaling Pathway.
Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function.
Methyltransferase-like enzyme 14 exacerbates retinal ganglion cell damage and diabetic retinopathy through N6-methyladenosine-dependent upregulation of pleckstrin homology domain and leucine rich repeat protein phosphatase 2.
CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistance.
MTA1-DT promotes endometrial cancer growth by modulating G2/M-related gene transcription via PURα.
Tracking of single virus: Dual fluorescent labeling of pseudorabies virus for observing entry and replication in the N2a cells.
Lingguizhugan Decoction improves chronic heart failure by synergistically modulating ?1-AR/Gs/GRKs/?-arrestin signaling bias.
IRF4 contributes to chemoresistance in IGH::BCL2-positive diffuse large B-cell lymphomas by mediating BCL2-induced SOX9 expression.
Identification and Functional Analysis of Novel Mutations in AXIN2 and LRP6 Linked With Non-Syndromic Tooth Agenesis.
TRAF3IP3 Induces ER Stress-Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation.
Inactivation of TACC2 epigenetically represses CDKN1A and confers sensitivity to CDK inhibitors.
Sciellin inhibits senescence and promotes pancreatic cancer progress by activating the notch signaling pathway.
A cardiac fibroblast-enriched micropeptide regulates inflammation in ischemia/reperfusion injury.
Alpha-lipoic acid alleviated intermittent hypoxia-induced myocardial injury in mice by promoting autophagy through Nrf2 signaling pathway.
Rab GTPases are evolutionarily conserved signals mediating selective autophagy.
KRT6A Restricts Influenza A Virus Replication by Inhibiting the Nuclear Import and Assembly of Viral Ribonucleoprotein Complex.
Ethanol extract of Moschus attenuates glutamate-induced cytotoxicity in HT22 cells by regulating the Nrf2 and MAPK pathways.
Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism.
Erucin Alleviates Cardiac Hypertrophy by Improving Mitochondrial Function via Nrf2-Sirt3 Pathway.
Pre-ischaemic empagliflozin treatment attenuates blood-brain barrier disruption via β-catenin mediated protection of cerebral endothelial cells.
The S273R protein of African swine fever virus antagonizes the canonical NF-κB signaling pathway by IκBα.
H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation.
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis.
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition.
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Novel Function of NUP153 in HNF4α Transcriptional Upregulation Contributes to Promoting HBV Replication.
Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice.
A subset of human dermal fibroblasts overexpressing Cockayne syndrome group B protein resist UVB radiation-mediated premature senescence.
USP13 inhibition exacerbates mitochondrial dysfunction and acute kidney injury by acting on MCL-1.
Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.
Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2/SIRT3 signaling pathway.
Rosa roxburghii Fermentation Broths Attenuate Bleomycin-Induced Pulmonary Fibrosis by Activating the Nrf2/HO-1/NQO1 Signaling Pathway and Modulating Gut Microbiota.
Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway.
Inhibiting HMGB1/AGER/NF-κB pathway prevents pro-inflammatory microglia polarization and protect photoreceptors in retinitis pigmentosa.
TEPP-46 inhibits glycolysis to promote M2 polarization of microglia after ischemic stroke.
Adipose progenitor cell-derived extracellular vesicles suppress macrophage M1 program to alleviate midlife obesity.
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers.
Small extracellular vesicles from young adipose-derived stem cells ameliorate age-related changes in the heart of old mice.
A novel KEAP1 inhibitor, tiliroside, activates NRF2 to protect against acetaminophen-induced oxidative stress and acute liver injury.
Arsenic exposure induces neural cells senescence and abnormal lipid droplet accumulation leading to social memory impairment in mice.
Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis.
Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis.
Natural compound PEITC inhibits gain of function of p53 mutants in cancer cells by switching YAP-binding partners between p53 and p73.
Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction.
Rictor orchestrates β-catenin/FOXO balance by maintaining redox homeostasis during development of ovarian cancer.
Targeting KPNB1 suppresses AML cells by inhibiting HMGB2 nuclear import.
Human Umbilical Cord Mesenchymal Stem Cells Alleviate Diabetic Nephropathy by Inhibiting Ferroptosis via the JNK/KEAP1/NRF2 Signaling Pathway.
Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment.
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
Targeted lipidomic reveals dietary LA/n-3 PUFAs regulate inflammation and redox status via oxylipins in bivalves.
LuQi formula ameliorates pressure overload-induced heart failure by regulating macrophages and regulatory T cells.
Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways.
Sulforaphane Promotes the Skeletal Muscle Postinjury Regeneration by Up-Regulating the Transcription of Prl2c2 through JAK2/STAT3 Signaling.
Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation.
Tumor-intrinsic TTLL12 drives resistance to cancer immunotherapy via modulating myeloid-derived suppressor cells.
Piezo1 disrupts blood-brain barrier via CaMKII/Nrf2 in ischemic stroke.
Novel drug-inducible CRISPRa/i systems for rapid and reversible manipulation of gene transcription.
ISCU-p53 axis orchestrates macrophage polarization to dictate immunotherapy response in esophageal squamous cell carcinoma.
Identification of CD84 as a potent survival factor in acute myeloid leukemia.
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
LMNB1 regulates breast cancer cell senescence and migration through PPAR signaling pathway.
Meloxicam Alleviates Oxidative Stress Through Nrf2/HO-1 Activation in Bovine Endometrial Epithelial Cells.
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy.
CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models.
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.
Pilot Exploration of RGMa-BMP4 Signaling in Neutrophil Activation in NMOSD: Integrating Clinical and Molecular Insights.
YY1/HIF-1α/mROS positive-feedback loop exacerbates glomerular mesangial cell proliferation in mouse early diabetic kidney disease.
Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A.
TP53INP2 promotes mitophagic degradation of YAP to impede dedifferentiated liposarcoma development.
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma.
Adipose-derived stem cells alleviate acute pancreatitis by inhibiting ferroptosis and oxidative damage in canines.
Irisin attenuates liver fibrosis by regulating energy metabolism and HMGB1/β-catenin signaling in hepatic stellate cells.
MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction.
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects.
Comprehensive multi-omics and pharmacokinetics reveal sclareol's role in inhibiting ocular neovascularization.
DNA damage response pathway regulates Nrf2 in response to oxidative stress.
Histone marks enable formation of immiscible phase-separated chromatin compartments.
CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism.
E3 ligase TRIM22 promotes melanoma proliferation by regulating cell cycle progression through K63-linked ubiquitination of p21.
The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling.
The serine protease DPP9 and the redox sensor KEAP1 form a mutually inhibitory complex.
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint.
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1.
STIM1 promotes cervical cancer progression through autophagy activation via TFEB nuclear translocation.
Protective Effects of α-Linolenic Acid on Liver Inflammation and Oxidative Stress Induced by Lipopolysaccharide in Broilers.
Bardoxolone methyl triggers Ferroptosis in cardiomyocytes.
Pedunculoside inhibits cardiomyocyte inflammatory biomarkers via Nrf2/HO-1 pathway in high glucose-induced H9c2 cells and diabetic cardiomyopathy model rats.
5-(3-(N-(Carboxymethyl)naphthalene-2-sulfonamido)phenyl)-1-ethyl-1H-pyrrole-2-carboxylic acid as a Keap1-Nrf2 inhibitor for cerebral ischemia/reperfusion injury treatment.
Processed Buthus martensii Karsch scorpions ameliorate diet-induced NASH in mice by attenuating Kv1.3-mediated macrophage activation.
Supplementation with carnosine, a food-derived bioactive dipeptide, alleviates dexamethasone-induced oxidative stress and bone impairment via the NRF2 signaling pathway.
Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages.
Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent m(6)A regulation.
PKM2-mediated collagen XVII expression is critical for wound repair.
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA.
Drug-induced senescence of donor dermal fibroblasts enhances revascularization and graft success in skin transplantation.
Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.
The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival.
Proline exacerbates hepatic gluconeogenesis via paraspeckle-dependent mRNA retention.
AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane.
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression.
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury.
Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea.
Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways.
Circ-Sirt6 promotes the stability and expression of m(6)A modified Sirt6 mRNA by recruiting IGF2BP2.
NUP98-p65 complex regulates DNA repair to maintain glioblastoma stem cells.
The Polybrominated Diphenyl Ether Bromoxib Disrupts Nuclear Import and Export by Affecting Nucleoporins of the Nuclear Pore Complex.
CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity.
8q24 derived ZNF252P promotes tumorigenesis by driving phase separation to activate c-Myc mediated feedback loop.
Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3.
Tumor vascular endothelial cells promote immune escape by upregulating PD-L1 expression via crosstalk between NF-κB and STAT3 signaling pathways in nasopharyngeal carcinoma.
Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer.
Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling.
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
Human iPSC-Derived Muscle Cells as a New Model for Investigation of EDMD1 Pathogenesis.
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
Inhibition of SCF(KDM2A)/USP22-dependent nuclear β-catenin ubiquitylation mediates cerebral ischemic tolerance.
Cepharanthine relieves nonalcoholic steatohepatitis through inhibiting STAT1/CXCL10 axis-mediated lipogenesis and inflammatory responses.
Electroacupuncture ameliorated locomotor symptoms in MPTP-induced mice model of Parkinson's disease by regulating autophagy via Nrf2 signaling.
SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation.
Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.
Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves.
YAP-mediated glycolysis promotes pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension.
Lipopolysaccharide-induced cytokine signaling activates a temporal innate defense program and represses pancreatic β-cell identity.
Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2.
Stage-specific TRIM10 expression regulates erythroid maturation.
Targeting MORF4L1-mediated DNA repair potentiates RT-induced antitumor immunity via cGAS-STING activation in hepatocellular carcinoma.
Inflammatory signaling attenuates spliceosome function and cognitive ability.
Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation.
Human bocavirus NP1 antagonizes host type I interferon response through repressing the nuclear transport of STAT1.
Reactivating T cell immunity in Wnt-hyperactivated non-small cell lung cancer through a supramolecular droplet of carnosic acid and peptide.
RIPK1 Drives JAK1-STAT3 Signaling to Promote CXCL1-Mediated Neutrophil Recruitment in Sepsis-Induced Lung Injury.
Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy.
Luteolin rescues myelin integrity and cognitive-motor function via Nrf2 pathway activation: a natural candidate vs. dimethyl fumarate in cuprizone-induced multiple sclerosis.
FAM189A2 activates Hippo signaling pathway by abrogating WWP2-mediated LATS1 ubiquitination, to inhibit the glycolysis and proliferation processes of lung adenocarcinoma.
Melatonin Supplementation Relieves Fluoride-Induced Bone Injury via Ion Homeostasis Disorder and PINK1/Parkin-Mediated Mitophagy.
UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression.
Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway.
Gpr109a alleviates mammary fibrosis via PPARγ-mediated reduction of ROS and mitochondrial damage.
Bruceine D promotes TNBC regression by inhibiting M2-like tumor-associated macrophage polarization induced Wnt3a/β-catenin pathway.
Sofalcone inhibits osteoclastogenesis through Keap1/Nrf2 signaling activation and mitigates ovariectomy-induced bone loss.
Uptake mechanisms and functions of isolated mitochondria in mesenchymal stromal cells.
Butin inhibits osteoarthritis progression by modulating the Nrf2/HO-1 signaling pathway and inhibiting NF-κB signaling.
Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration.
Nonsense-mediated mRNA decay inhibits TRAF6-dependent anti-tumor immunity in colorectal cancer.
Gut microbiome-derived indole-3-carboxaldehyde promotes intestinal development via AHR-NRF2 signaling in the early-life of chicks.
Early life exposure to environmental levels of PCB138 induces lipid metabolism disorders through activating aryl hydrocarbon receptor in female mice.
Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus.
Endothelial mechanosensitive transcription factor BHLHE40 induced by Piezo1 suppresses endothelial ferroptosis and inflammation via SLC7A11.
LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity.
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation.
SDF2L1 downregulation mediates high glucose-caused Schwann cell dysfunction by inhibiting nuclear import of TFEB and CREB via KPNA3.
Tianma Granules Alleviate AOM/DSS-Induced Colorectal Tumorigenesis by Inhibiting the Wnt/β-Catenin Pathway Activation.
Discovery of a novel polyketide-derived ferroptosis inhibitor from endophytic fungus Ophiobolus cirsii LZU-1509 with therapeutic potential in ischemic stroke.
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.
SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy.
RONIN/HCF1-TFEB Axis Protects Against D-Galactose-Induced Cochlear Hair Cell Senescence Through Autophagy Activation.
LIMK1 as a Novel Kinase of β-Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5.
Newcastle disease virus induces degradation of folliculin to regulate host cell energy metabolism and facilitate viral replication.
AR to GR switch modulates differential TDO2-Kyn-AhR signalling to promote the survival and recurrence of treatment-induced dormant cells in prostate cancer.
Bufalin inhibits hepatocellular carcinoma progression by blocking EGFR-mediated RAS-RAF-MEK-ERK pathway activation.
Piezo1 promotes colitis progression by modulating the Nrf2/NF-κB/NLRP3 signaling pathway.
Circulatory extracellular vesicles transport complement C1q for promoting neuronal amyloid-β production in Alzheimer's disease.
Curcumin analog C1 activates autophagy through a TFEB-dependent mechanism to protect sensory hair cells from oxidative stress in C57BL/6 mice with age-related hearing loss.
NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer.
Liver regeneration-associated hepatocellular YAP1 activation prevents colorectal cancer liver metastasis through glutamine competition.
Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline.
SIRT1 and its SUMOylation attenuate hyperoxia-induced lung injury by improving mitochondrial biogenesis and fusion.
PDE4D Regulates Mitochondrial Homeostasis and Adult Hippocampal Neurogenesis via the cAMP/CREB Signaling Pathway in Chronic Stress-Induced Depressive-Like Behavior.
UBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice.
LncRNA EP300-AS1 interacts with PTBP1 to destabilize PRMT5 mRNA and suppresses NSCLC growth and metastasis.
VPS45 Contributes to the Progression of Hepatocellular Carcinoma by Triggering the Wnt/β-Catenin Signaling Pathway.
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Subcellular proteomics reveals the crosstalk between nucleocytoplasmic trafficking and the innate immune response to Senecavirus A infection.
Nrf2 alleviates acute ischemic stroke induced ferroptosis via regulating xCT/GPX4 pathway.
Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics.
Yinaoxin granule alleviates cerebral ischemia-reperfusion injury by ferroptosis inhibition through Nrf2 pathway activation.
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases.
Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non-Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production.
Tanshinone IIA Ameliorates Myocardial Ischemia-Reperfusion Injury via Activating HDAC1-Repressed Nrf2-xCT/Gpx4/HO-1 Axis.
The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses.
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis.
Structural optimization and characterization of highly potent and selective STAT3 inhibitors for the treatment of triple negative breast cancer.
HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages.
PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth.
A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide.
Tricetin, a Dietary Flavonoid, Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the PI3K/Akt/mTOR Signaling Pathway.
MiR•101 and miR•122 Targeting δ-Catenin to Regulate Keratinocyte Responsiveness to IL-17A in Psoriasis.
The ZBTB24-CDCA7-HELLS axis suppresses the totipotent 2C-like reprogramming by maintaining Dux methylation and repression.
Aquaporin 9 downregulation in KRAS(G12V) colorectal cancer and associated with increased proliferation and decreased apoptosis in cancer cells.
A novel TLR4 accessory molecule drives hepatic oncogenesis through tumor-associated macrophages.
Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity.
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis.
Berberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice.
HMGB1 Modulates High Glucose-Induced Erroneous Differentiation of Tendon Stem/Progenitor Cells through RAGE/β-Catenin Pathway.
SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.
CAPE activates AMPK and Foxo3 signaling to induce growth inhibition and ferroptosis in triple-negative breast cancer.
The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies.
Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis.
Elucidating the role of 4-hydroxy-2(3H)-benzoxazolone in chronic alcoholic liver disease via transcriptomics and metabolomics.
Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes.
PFKFB3 deprivation attenuates the cisplatin resistance via blocking its autophagic elimination in colorectal cancer cells.
Bergamottin (Ber) ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway.
Anti-inflammatory and uric acid lowering effects of Euodiae fructus on hyperuricemia and gout mice.
Deciphering m(6)A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy.
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway.
The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice.
Intervention of Asprosin Attenuates Oxidative Stress and Neointima Formation in Vascular Injury.
Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway.
Usutu virus NS4A suppresses the host interferon response by disrupting MAVS signaling.
The I7L protein of African swine fever virus is involved in viral pathogenicity by antagonizing the IFN-γ-triggered JAK-STAT signaling pathway through inhibiting the phosphorylation of STAT1.
Polystyrene nanoparticles trigger aberrant condensation of TDP-43 and amyotrophic lateral sclerosis-like symptoms.
Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L.
Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by γ-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells.
USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling.
FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes.
Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents.
YIPF2 regulates genome integrity.
Anoectochilus roxburghii polysaccharide reduces D-GalN/LPS-induced acute liver injury by regulating the activation of multiple inflammasomes.
Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis.
Unveiling the anticancer potential of plumbagin: targeting pyruvate kinase M2 to induce oxidative stress and apoptosis in hepatoma cells.
Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton.
VP3 protein of Senecavirus A promotes viral IRES-driven translation and attenuates innate immunity by specifically relocalizing hnRNPA2B1.
Alkaloids of Aconiti Lateralis Radix Praeparata inhibit growth of non-small cell lung cancer by regulating PI3K/Akt-mTOR signaling and glycolysis.
Tryptanthrin targets GSTP1 to induce senescence and increases the susceptibility to apoptosis by senolytics in liver cancer cells.
Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H(2)O(2)-Induced Neuronal PC12 Cells and Prolongs the Lifespan of Caenorhabditis elegans.
Calcipotriol abrogates TGF-β1/pSmad3-mediated collagen 1 synthesis in pancreatic stellate cells by downregulating RUNX1.
The impact of NUMB on chicken abdominal adipogenesis: A comprehensive analysis.
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise.
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
Protein inhibitor of activated signal transducer and activator of transcription 2 is an oncoprotein in oral squamous cell carcinoma and related to cigarette smoking - An in vitro study.
Low-dose radiation promotes high-fat diet-induced atherosclerosis by activating cGAS signal pathway.
Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer.
Targeting SNAI1-Mediated Colorectal Cancer Chemoresistance and Stemness by Sphingosine Kinase 2 Inhibition.
Oleanolic acid attenuates obesity through modulating the lipid metabolism in high-fat diet-fed mice.
Orientin promotes diabetic wounds healing by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
The syntaxin-binding protein STXBP5 regulates progerin expression.
Tumor cell-intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance.
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
LAP2alpha facilitates myogenic gene expression by preventing nucleoplasmic lamin A/C from spreading to active chromatin regions.
Myrislignan ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
CRISPR associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons resulting in KRAB-specific degradation.
Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin.
A TBK1-independent primordial function of STING in lysosomal biogenesis.
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance.
HIF-1α regulates mitochondrial function in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages.
Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling.
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice.
TRIM33 promotes glycolysis through regulating P53 K48-linked ubiquitination to promote esophageal squamous cell carcinoma growth.
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders.
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
Downregulation of short-stature homeobox protein 2 suppresses gastric cancer cell growth and stemness in vitro and in vivo via inactivating wnt/β-catenin signaling.
Combined treatment with Aronia berry extract and oligomeric proanthocyanidins exhibit a synergistic anticancer efficacy through LMNB1-AKT signaling pathways in colorectal cancer.
Sappanone A ameliorates acute lung injury through inhibiting the activation of the NF-κB signaling pathway.
CypA/TAF15/STAT5A/miR-514a-3p feedback loop drives ovarian cancer metastasis.
Ginkgo Flavone Aglycone Ameliorates Atherosclerosis via Inhibiting Endothelial Pyroptosis by Activating the Nrf2 Pathway.
Metformin attenuates PM(2.5)-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells.
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
SIRT2 regulates high mobility group protein B1 nucleoplasmic shuttle and degradation via deacetylation in microglia.
Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.
Bipartite nuclear localization sequence is indispensable for nuclear import and stability of self-dimerization of ADARa in Bombyx mori.
Eupafolin hinders cross-talk between gastric cancer cells and cancer-associated fibroblasts by abrogating the IL18/IL18RAP signaling axis.
TMEM232 is required for the formation of sperm flagellum and male fertility in mice.
ML385 promotes ferroptosis and radiotherapy sensitivity by inhibiting the NRF2-SLC7A11 pathway in esophageal squamous cell carcinoma.
LncRNA DDX11-AS1 promotes breast cancer progression by targeting the miR-30c-5p/MTDH axis.
BAP1 inactivation promotes lactate production by leveraging the subcellular localization of LDHA in melanoma.
Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ.
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.
P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker.
Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema.
METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.
Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2/GPX4 axis.
Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways.
The deleterious effects of CDK4/6 inhibition on renal recovery post-acute kidney injury.
Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis.
ER-tethered RNA-binding protein controls NADPH oxidase translation for hydrogen peroxide homeostasis.
OTUD6A orchestrates complex modulation of TEAD4-mediated transcriptional programs.
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3.
Polyene phosphatidylcholine enhances the therapeutic response of oxaliplatin in gastric cancer through Nrf2/HMOX1 mediated ferroptosis.
Icariin ameliorates glycolytic dysfunction in Alzheimer's disease models by activating the Wnt/β-catenin signaling pathway.
SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia.
An integrated multi-omics analysis reveals osteokines involved in global regulation.
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress.
p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol.
Heat stress upregulates arachidonic acid to trigger autophagy in sertoli cells via dysfunctional mitochondrial respiratory chain function.
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.
Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm.
An integrated network pharmacology, molecular docking and experiment validation study to investigate the potential mechanism of Isobavachalcone in the treatment of osteoarthritis.
Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice.
Dexamethasone-Integrated Mesenchymal Stem Cells for Systemic Lupus Erythematosus Treatment via Multiple Immunomodulatory Mechanisms.
Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice.
Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging.
The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.
Tumor derived exosomal ENTPD2 impair CD8(+) T cell function in colon cancer through ATP-adenosine metabolism reprogramming.
Metformin induction of heat shock factor 1 activation and the mitochondrial unfolded protein response alleviate cardiac remodeling in spontaneously hypertensive rats.
6PPDQ induces cardiomyocyte senescence via AhR/ROS-mediated autophagic flux blockage.
25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages.
Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts.
Edaravone dexborneol protects against cerebral ischemia/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2/HO-1/GPX4 signaling.
M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes.
Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation.
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Circular RNA-circLRP6 protects cardiomyocyte from hypoxia-induced apoptosis by facilitating hnRNPM-mediated expression of FGF-9.
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
HuR-positive stress granules: Potential targets for age-related osteoporosis.
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
CDK12 inhibition upregulates ATG7 triggering autophagy via AKT/FOXO3 pathway and enhances anti-PD-1 efficacy in colorectal cancer.
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping.
LuQi formula attenuates Cardiomyocyte ferroptosis via activating Nrf2/GPX4 signaling axis in heart failure.
Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
Lentinan inhibits cell invasion via M2 polarization of tumor-associated macrophages and Wnt/β-catenin signaling in non-small cell lung cancer.
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
Integrated Transcriptomic and Proteomic Study of the Mechanism of Action of the Novel Small-Molecule Positive Allosteric Modulator 1 in Targeting PAC1-R for the Treatment of D-Gal-Induced Aging Mice.
Securin acetylation prevents precocious separase activation and premature sister chromatid separation.
African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway.
Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation.
ApoE maintains neuronal integrity via microRNA and H3K27me3-mediated repression.
Different concentrations of betaxolol switch cell fate between necroptosis, apoptosis, and senescence in human corneal stromal cells.
Essential oil from Fructus Alpiniae zerumbet ameliorates vascular endothelial cell senescence in diabetes by regulating PPAR-γ signalling: A 4D label-free quantitative proteomics and network pharmacology study.
Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells.
The small nucleolar RNA SNORA51 enhances breast cancer stem cell-like properties via the RPL3/NPM1/c-MYC pathway.
Sodium Butyrate Ameliorates Atopic Dermatitis-Induced Inflammation by Inhibiting HDAC3-Mediated STAT1 and NF-κB Pathway.
Arecoline induces neurotoxicity in HT22 cells via the promotion of endoplasmic reticulum stress and downregulation of the Nrf2/HO-1 pathway.
Inhibitor of apoptosis stimulating protein of p53 protects against MPP(+)-induced neurotoxicity of dopaminergic neurons.
Myricanol attenuates sepsis-induced inflammatory responses by nuclear factor erythroid 2-related factor 2 signaling and nuclear factor kappa B/mitogen-activated protein kinase pathway via upregulating Sirtuin 1.
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA.
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4.
Total flavonoids of Broussonetia papyrifera alleviate non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signaling pathways.
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.
Tumor suppressive role of the epigenetic master regulator BRD3 in colorectal cancer.
Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases.
Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target.
Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the Akt/mTOR Signaling Pathway.
Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients.
Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis.
2'-Hydroxycinnamaldehyde Alleviates Intestinal Inflammation by Attenuating Intestinal Mucosal Barrier Damage Via Directly Inhibiting STAT3.
Oncogenic functions and therapeutic potentials of targeted inhibition of SMARCAL1 in small cell lung cancer.
Obg-like ATPase 1 exacerbated gemcitabine drug resistance of pancreatic cancer.
Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response.
Asprosin promotes vascular inflammation via TLR4-NFκB-mediated NLRP3 inflammasome activation in hypertension.
Transmissible gastroenteritis virus induces inflammatory responses via RIG-I/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo.
Amelioration of NAFLD by sleeve gastrectomy-triggered hepatocyte regeneration in mice - experimental research.
Chidamide enhances T-cell-mediated anti-tumor immune function by inhibiting NOTCH1/NFATC1 signaling pathway in ABC-type diffuse large B-cell lymphoma.
Sleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating TGF-β1/Smad3 signaling pathway.
Energy stress promotes P-bodies formation via lysine-63-linked polyubiquitination of HAX1.
P7C3 suppresses astrocytic senescence to protect dopaminergic neurons: Implication in the mouse model of Parkinson's disease.
Tubular insulin-induced gene 1 deficiency promotes NAD(+) consumption and exacerbates kidney fibrosis.
Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis.
Icariside II modulates pulmonary fibrosis via PI3K/Akt/β-catenin pathway inhibition of M2 macrophage program.
Salvianolic acid B protects against UVB-induced skin aging via activation of NRF2.
Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver.
Excess endocrine growth hormone in acromegaly promotes the aggressiveness and metastasis of triple-negative breast cancer.
N1-Acetyl-5-methoxykynuramine, which decreases in the hippocampus with aging, improves long-term memory via CaMKII/CREB phosphorylation.
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry.
Nuclear translocation of Axl contributes to the malignancy of oral cancer cells.
SETD2 loss in renal epithelial cells drives epithelial-to-mesenchymal transition in a TGF-β-independent manner.
Osteoblast-derived exosomes promote osteogenic differentiation of osteosarcoma cells via URG4/Wnt signaling pathway.
Metformin: A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation.
A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.
Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis.
Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex.
Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype.
Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH-SY5Y cells and Caenorhabditis elegans.
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells.
Jianpi Huayu Decoction suppresses cellular senescence in colorectal cancer via p53-p21-Rb pathway: Network pharmacology and in vivo validation.
Selenium suppressed the LPS-induced oxidative stress of bovine endometrial stromal cells through Nrf2 pathway with high cortisol background.
Taurine Chloramine-Mediated Nrf2 Activation and HO-1 Induction Confer Protective Effects in Astrocytes.
A complex of cadherin 17 with desmocollin 1 and p120-catenin regulates colorectal cancer migration and invasion according to the cell phenotype.
NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1.
Discovery from Hypericum elatoides and synthesis of hyperelanitriles as α-aminopropionitrile-containing polycyclic polyprenylated acylphloroglucinols.
Dietary long-chain fatty acids promote colitis by regulating palmitoylation of STAT3 through CD36-mediated endocytosis.
Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells.
Acylated Ghrelin Activates PI3K/mTOR Signaling Pathway by Promoting ThPOK Acetylation to Promote Milk Fat Synthesis in Bovine Mammary Epithelial Cells.
Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.
Heterologous expression of Dictyostelium discoideum NE81 in mouse embryo fibroblasts reveals conserved mechanoprotective roles of lamins.
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cascade.
LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages.
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis.
Sodium butyrate alleviates lead-induced neuroinflammation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway.
The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis.
NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition.
Peroxiredoxin 3 regulates breast cancer progression via ERK-mediated MMP-1 expression.
Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis.
MKK3 K329 Mutation Attenuates Diabetes-Associated Cognitive Dysfunction by Blocking the MKK3-RAGE Interaction and Inhibiting Neuroinflammation.
A GAPDH serotonylation system couples CD8(+) T cell glycolytic metabolism to antitumor immunity.
Self-Healing Micro Arc Oxidation and Dicalcium Phosphate Dihydrate Double-Passivated Coating on Magnesium Membrane for Enhanced Bone Integration Repair.
OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation.
Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling.
Protein arginine methyltransferase 5 confers the resistance of triple-negative breast cancer to nanoparticle albumin-bound paclitaxel by enhancing autophagy through the dimethylation of ULK1.
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma.
TGN-020 ameliorates motor dysfunction post-spinal cord injury via enhancing astrocyte autophagy and mitigating inflammation by activating AQP4/PPAR-γ/mTOR pathway.
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels.
The noncanonical RNA-binding protein RAN stabilizes the mRNA of intranuclear stress granule assembly factor G3BP1 in nasopharyngeal carcinoma.
Porcine reproductive and respiratory syndrome virus activates lipid synthesis through a ROS-dependent AKT/PCK1/INSIG/SREBPs axis.
An artificial peptide inhibits autophagy through calcineurin-TFEB pathway.
Discovery of novel 5-phenyl-1H-pyrrole-2-carboxylic acids as Keap1-Nrf2 inhibitors for acute lung injury treatment.
Bushen Huoxue Yiqi formula alleviates cardiac fibrosis in ischemic heart failure through SIRT1/Notch1 pathway-mediated EndMT.
The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα.
Impact of Nuclear Peripheral Chromatin Lamin LMNB1 Gene in the Proliferation and Migration of Glioma Cells.
Maternal exposure to 4-tert-octylphenol causes alterations in the morphology and function of microglia in the offspring mouse brain.
Lycopodium japonicum Thunb. inhibits chondrocyte apoptosis, senescence and inflammation in osteoarthritis through STING/NF-κB signaling pathway.
A low level of tumor necrosis factor α in tumor microenvironment maintains the self-renewal of glioma stem cells by Vasorin-mediated glycolysis.
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Nuciferine ameliorates osteoarthritis: An in vitro and in vivo study.
Subcellular Proteomic Mapping of Lysine Lactylation.
Impeding Nucleotide-Binding Oligomerization Domain-Like Receptor 3 Inflammasome Ameliorates Cardiac Remodeling and Dysfunction in Obesity-Associated Cardiomyopathy.
Mesenchymal stromal cells reduce inflammation and improve lung function in a mouse model of cystic fibrosis lung disease.
Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO-1 pathway.
Isolicoflavonol ameliorates acute liver injury via inhibiting NLRP3 inflammasome activation through boosting Nrf2 signaling in vitro and in vivo.
M6A modification-mediated LIMA1 promotes the progression of hepatocellular carcinoma through the wnt-βcatenin/Hippo pathway.
Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways.
Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases.
Alpha-lipoic acid targets KLF7 expression to inhibit cervical cancer progression.
BRD7 regulates cellular senescence and apoptosis in ALS by modulating p21 expression and p53 mitochondrial translocation respectively.
Matrix stiffness regulates macrophage polarisation via the Piezo1-YAP signalling axis.
Serum deprivation protein response intervenes in the proliferation, motility, and extracellular matrix production in keloid fibroblasts by blocking the amplification of TGF-β1/SMAD signal cascade via ERK1/2.
STIL facilitates the development and malignant progression of triple-negative breast cancer through activation of Fanconi anemia pathway via interacting with KLF16.
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport.
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer.
Erastin promotes random-pattern skin flaps survival by inducing mTORC1-TFEB mediated autophagy.
Reversing MET-Mediated Resistance in Oncogene-Driven NSCLC by MET-Activated Wnt Condensative Prodrug.
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2.
βA3/A1-crystallin is an epigenetic regulator of histone deacetylase 3 (HDAC3) in the retinal pigmented epithelial (RPE) cells.
Air-ventilated normothermic mechanical perfusion improves susceptibility to donation after circulatory death and cold preservation-induced cholestatic liver injury through PPAR-γ/UGT1A1 axis.
Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironment.
SMYD5 is a regulator of the mild hypothermia response.
SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion.
Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy.
Immunomodulation in Endometriosis: Investigating the interrelationship between VISTA expression and Escherichia.Shigella-Associated metabolites.
Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I.
Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation.
Breast cancer cells have an increased ferroptosis risk induced by system x(c)(-) blockade after deliberately downregulating CYTL1 to mediate malignancy.
CRISPR/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt/β-catenin signaling pathway.
Icariin alleviates renal inflammation and tubulointerstitial fibrosis via Nrf2-mediated attenuation of mitochondrial damage.
Ursolic acid attenuates cholestasis through NRF2-mediated regulation of UGT2B7 and BSEP/MRP2.
Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells.
Pimpinellin ameliorates macrophage inflammation by promoting RNF146-mediated PARP1 ubiquitination.
Danshensu methyl ester attenuated LPS-induced acute lung injury by inhibiting TLR4/NF-κB pathway.
GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway.
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.
Nucleoporin93 limits Yap activity to prevent endothelial cell senescence.
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.
African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways.
SIRT1-dependent PGC-1α deacetylation by SRT1720 rescues progression of atherosclerosis by enhancing mitochondrial function.
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
Baicalein ameliorated obesity-induced cardiac dysfunction by regulating the mitochondrial unfolded protein response through NRF2 signaling.
Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction.
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection.
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1.
Procyanidin B2 alleviates oxidized low-density lipoprotein-induced cell injury, inflammation, monocyte chemotaxis, and oxidative stress by inhibiting the nuclear factor kappa-B pathway in human umbilical vein endothelial cells.
Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis.
CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction.
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.
Rosamultin ameliorates radiation injury via promoting DNA injury repair and suppressing oxidative stress in vitro and in vivo.
Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway.
Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation.
C6orf15 promotes liver metastasis via WNT/β-catenin signalling in colorectal cancer.
CMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells.
Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury.
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis.
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
LINE-1 mRNA 3' end dynamics shape its biology and retrotransposition potential.
Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability.
Transcription Factor-Mediated Differentiation of Motor Neurons from Human Pluripotent Stem Cells.
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
Penfluroidol Attenuates the Imbalance of the Inflammatory Response by Repressing the Activation of the NLRP3 Inflammasome and Reduces Oxidative Stress via the Nrf2/HO-1 Signaling Pathway in LPS-Induced Macrophages.
Pterostilbene Confers Protection against Diquat-Induced Intestinal Damage with Potential Regulation of Redox Status and Ferroptosis in Broiler Chickens.
Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway.
Caffeic acid phenethyl ester suppresses metastasis of breast cancer cells by inactivating FGFR1 via MD2.
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Indole-3-Aldehyde Reduces Inflammatory Responses and Restores Intestinal Epithelial Barrier Function Partially via Aryl Hydrocarbon Receptor (AhR) in Experimental Colitis Models.
Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1.
Functional identification of two novel variants and a hypomorphic variant in ASS1 from patients with Citrullinemia type I.
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.
The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure.
Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma negatively regulates telomere length.
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study.
LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes.
African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING.
The African swine fever virus I10L protein inhibits the NF-κB signaling pathway by targeting IKKβ.
An antioxidant feedforward cycle coordinated by linker histone variant H1.2 and NRF2 that drives nonsmall cell lung cancer progression.
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement.
The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.
PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis.
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis.
Follicular fluid derived exosomal miR-4449 regulates cell proliferation and oxidative stress by targeting KEAP1 in human granulosa cell lines KGN and COV434.
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics.
Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.
Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis.
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.
Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells.
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) Hexanol Inhibits Proliferation and Induces Apoptosis of Endometriosis by Regulating Glutathione S-Transferase Mu Class 4.
Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation.
Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via a nuclear receptor (Nur77)-mediated epigenetic regulation of glutaminase 1.
D-mannose acts as a V-ATPase inhibitor to suppress inflammatory cytokines generation and bacterial killing in macrophage.
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.
Two palladium (II) complexes derived from halogen-substituted Schiff bases and 2-picolylamine induce parthanatos-type cell death in sensitive and multi-drug resistant CCRF-CEM leukemia cells.
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain.
African Swine Fever Virus pF778R Attenuates Type I Interferon Response by Impeding STAT1 Nuclear Translocation.
Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456.
Umbilical Cord Mesenchymal-Stem-Cell-Derived Exosomes Exhibit Anti-Oxidant and Antiviral Effects as Cell-Free Therapies.
CSTF2 mediated mRNA N(6)-methyladenosine modification drives pancreatic ductal adenocarcinoma m(6)A subtypes.
Diosgenin prevents dexamethasone-induced myotube atrophy in C2C12 cells.
Stattic ameliorates the cecal ligation and puncture-induced cardiac injury in septic mice via IL-6-gp130-STAT3 signaling pathway.
USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway.
MiR-196b-5p activates NF-κB signaling in non-small cell lung cancer by directly targeting NFKBIA.
Nuclear translocation of PKM2 mediates keratinocyte metabolic reprogramming in psoriasis.
Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF-κB pathway in grass carp.
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING-dependent therapy-induced senescence and provides "one-two punch" opportunity with anti-PD-L1 therapy in colorectal cancer.
Promotion of colorectal cancer progression by immune-related lnc-SOX9-4 via suppression of YBX1 poly-ubiquitination and degradation.
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy.
Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells.
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis.
AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.
C-X-C domain ligand 14-mediated stromal cell-macrophage interaction as a therapeutic target for hand dermal fibrosis.
Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant.
Nucleoporin93 (Nup93) Limits Yap Activity to Prevent Endothelial Cell Senescence.
Naringenin in Si-Ni-San formula inhibits chronic psychological stress-induced breast cancer growth and metastasis by modulating estrogen metabolism through FXR/EST pathway.
Mitochondrial transplant after ischemia reperfusion promotes cellular salvage and improves lung function during ex-vivo lung perfusion.
Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration.
eIF2α incites photoreceptor cell and retina damage by all-trans-retinal.
ER export signals mediate plasma membrane localization of transmembrane protein TMEM72.
Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing.
Pioglitazone can improve liver sex hormone-binding globulin levels and lipid metabolism in polycystic ovary syndrome by regulating hepatocyte nuclear factor-4α.
Periplocin targets low density lipoprotein receptor-related protein 4 to attenuate osteoclastogenesis and protect against osteoporosis.
C1q/tumor necrosis factor-related protein-9 exerts antioxidant and anti-inflammatory effects on oxygen-glucose deprivation/reoxygenation-stimulated neurons by modulating the Akt-GSK-3β-Nrf2 cascade via AdipoR1.
Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway.
Targeting mTOR/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation.
Involvement of canonical Wnt/β-catenin signaling in the extinction of auditory fear conditioning in male mice.
Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling.
HCMV Infection Reduces Nidogen-1 Expression, Contributing to Impaired Neural Rosette Development in Brain Organoids.
Human Cytomegalovirus IE1 Impairs Neuronal Migration by Downregulating Connexin 43.
Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines.
Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Sivelestat sodium attenuates acute lung injury by inhibiting JNK/NF-κB and activating Nrf2/HO-1 signaling pathways.
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins.
Promoting TFEB nuclear localization with curcumin analog C1 attenuates sensory hair cell injury and delays age-related hearing loss in C57BL/6 mice.
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.
Stabilization of nuclear β-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance.
Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration.
CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis.
UVA1 irradiation attenuates collagen production via Ficz/AhR/MAPK signaling activation in scleroderma.
Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.
Myb Repression Mediates Stat5b-knockdown-induced Apoptosis and Inhibits Proliferation of Glioblastoma Stem Cells.
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition.
BMAL1 Promotes Valvular Interstitial Cells' Osteogenic Differentiation through NF-κ B/AKT/MAPK Pathway.
DNAJB7 is dispensable for male fertility in mice.
Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice.
p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway.
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
Arachidonic acid impairs the function of the blood-testis barrier via triggering mitochondrial complex-ROS-P38 MAPK axis in hyperthermal Sertoli cells.
AQP8 may affect glioma proliferation and growth by regulating GSK-3β phosphorylation and nuclear transport of β-catenin.
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.
Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure.
Acetylation regulates the nucleocytoplasmic distribution and oncogenic function of karyopherin alpha 2 in lung adenocarcinoma.
The p23 co-chaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis.
TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly.
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.
Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges.
LncRNA ZNF593-AS alleviates diabetic cardiomyopathy via suppressing IRF3 signaling pathway.
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition.
Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies.
Transforming acidic coiled-coil containing protein 3 suppresses influenza A virus replication by impeding viral endosomal trafficking and nuclear import.
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro.
The mitophagy receptor NIX induces vIRF-1 oligomerization and interaction with GABARAPL1 for the promotion of HHV-8 reactivation-induced mitophagy.
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
Upregulation of CDGSH iron sulfur domain 2 attenuates cerebral ischemia/reperfusion injury.
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Aloperine alleviates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome activation.
Epigenetic plasticity safeguards heterochromatin configuration in mammals.
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis.
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway.
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.
P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases.
Dynamics and Composition of Small Heat Shock Protein Condensates and Aggregates.
Microcystin‑leucine arginine promotes colorectal cancer cell proliferation by activating the PI3K/Akt/Wnt/β‑catenin pathway.
VASN promotes colorectal cancer progression by activating the YAP/TAZ and AKT signaling pathways via YAP.
Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion.
Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal.
A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.
IKKα aggravates renal fibrogenesis by positively regulating the Wnt/β-catenin pathway.
Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.
Sclareol ameliorates liver injury by inhibiting nuclear factor-kappa B/NOD-like receptor protein 3-mediated inflammation and lipid metabolism disorder in diabetic mice.
Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB.
Novel Missense Variants in PAX8 and NKX2-1 Cause Congenital Hypothyroidism.
Dual functional antioxidant and butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of novel melatonin-alkylbenzylamine hybrids.
The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-β pathway.
DNA topoisomerase 2-associated proteins PATL1 and PATL2 regulate the biogenesis of hERG K(+) channels.
ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2.
Trans-anethole exerts protective effects on lipopolysaccharide-induced acute jejunal inflammation of broilers via repressing NF-κB signaling pathway.
Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading.
Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway.
The hnRNP C tetramer binds to CBC on mRNA and impedes PHAX recruitment for the classification of RNA polymerase II transcripts.
Cytosolic Release of Mitochondrial DNA and Associated cGAS Signaling Mediates Radiation-Induced Hematopoietic Injury of Mice.
HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity.
Identification and validation of microtubule depolymerizing agent, CYT997, as a potential drug candidate for hepatocellular carcinoma.
20-Deoxyingenol alleviates intervertebral disc degeneration by activating TFEB in nucleus pulposus cells.
Scribble promotes fibrosis-dependent mechanisms of hepatocarcinogenesis by p53/PUMA-mediated glycolysis.
Chemical constituents from Eupatorium fortunei and their anti-inflammatory evaluation by in silico and experimental approaches.
USP7 promotes non-small-cell lung cancer cell glycolysis and survival by stabilizing and activating c-Abl.
PGC1α deficiency reverses cholestasis-induced liver injury via attenuating hepatic inflammation and promoting bile duct remodeling.
Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc.
Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion.
A20 ameliorates Aspergillus fumigatus keratitis by promoting autophagy and inhibiting NF-κB signaling.
Ubiquitination-dependent degradation of nucleolin mediated by porcine circovirus type 3 capsid protein.
Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages.
NDRG3 regulates imatinib resistance by promoting β‑catenin accumulation in the nucleus in chronic myelogenous leukemia.
The MGF300-2R protein of African swine fever virus is associated with viral pathogenicity by promoting the autophagic degradation of IKKα and IKKβ through the recruitment of TOLLIP.
NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1(G93A) mutation and exerts neuroprotection in amyotrophic lateral sclerosis.
RNF4 and USP7 cooperate in ubiquitin-regulated steps of DNA replication.
Sculponeatin A promotes the ETS1-SYVN1 interaction to induce SLC7A11/xCT-dependent ferroptosis in breast cancer.
Curcumin Alleviates Singapore Grouper Iridovirus-Induced Intestine Injury in Orange-Spotted Grouper (Epinephelus coioides).
Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition.
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner.
Subcellular localization shapes the fate of RNA polymerase III.
Boron-Doped Carbon Nanodots as a Theranostic Agent for Colon Cancer Stem Cells.
NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways.
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/β-catenin signaling pathway through autophagy.
Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope.
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner.
Atractylenolide III suppresses senescence-associated secretome via inhibiting cGAS/NF-κB pathway in hepatic stellate cells.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases.
ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.
Multi-omics and network pharmacology study reveals the effects of Dengzhan Shengmai capsule against neuroinflammatory injury and thrombosis induced by ischemic stroke.
Effects of Sepsis Serum on the Fate of Adipose Tissue-Derived Stem Cells.
SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
Mechanisms Underlying the Suppression of IL-1β Expression by Magnesium Hydroxide Nanoparticles.
ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response.
Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling.
IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity.
SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction.
Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway.
Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H(2)O(2)-induced liver injury in HepG2 cells.
Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway.
Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease.
Effect of Lycium barbarum Polysaccharide on Decreasing Serum Amyloid A3 Expression through Inhibiting NF-κB Activation in a Mouse Model of Diabetic Nephropathy.
TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway.
Dopamine Suppresses Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells via AKT/GSK-3β/β-Catenin Signaling Pathway.
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway.
Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption of the Nuclear Lamina, TDP-43 Mislocalization and Cell Death.
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway.
Pitx3 deficiency promotes age-dependent alterations in striatal medium spiny neurons.
Selective targeting of MD2 attenuates intestinal inflammation and prevents neonatal necrotizing enterocolitis by suppressing TLR4 signaling.
MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation.
Phosphatidylethanolamine-binding protein 4 deficiency exacerbates carbon tetrachloride-induced liver fibrosis by regulating the NF-κB signaling pathway.
Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway.
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
The miR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance via the regulation of the TGF-β signal pathway.
The Antigastric Cancer Effect of Triptolide is Associated With H19/NF-κB/FLIP Axis.
Baicalein Prevents Fructose-Induced Hepatic Steatosis in Rats: In the Regulation of Fatty Acid De Novo Synthesis, Fatty Acid Elongation and Fatty Acid Oxidation.
Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα-NF-κB p65 Complex.
TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma.
Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway.
Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells.
Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion.
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Theaflavin Attenuates TBHP-Induced Endothelial Cells Oxidative Stress by Activating PI3K/AKT/Nrf2 and Accelerates Wound Healing in Rats.
miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.
IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells.
Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.
PGM3 regulates beta-catenin activity to promote colorectal cancer cell progression.
Induction of ferroptosis selectively eliminates senescent tubular cells.
Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection.
Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis.
Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity.
The pH sensor and ion binding of NhaD Na(+) /H(+) antiporter from IT superfamily.
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms.
African Swine Fever Virus pI215L Inhibits Type I Interferon Signaling by Targeting Interferon Regulatory Factor 9 for Autophagic Degradation.
Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways.
Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses.
A Novel lncRNA Mediates the Delayed Tooth Eruption of Cleidocranial Dysplasia.
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.
Schisandra chinensis (Turcz.) Baill. essential oil exhibits antidepressant-like effects and against brain oxidative stress through Nrf2/HO-1 pathway activation.
1,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes.
Cold exposure-induced endoplasmic reticulum stress regulates autophagy through the SIRT2/FoxO1 signaling pathway.
Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway.
Skin chronological aging drives age-related bone loss via secretion of cystatin-A.
Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin α7 is counteracted by TBK1-p62 axis-mediated autophagy.
LncRNA LINC00281/Annexin A2 Regulates Vascular Smooth Muscle Cell Phenotype Switching via the Nuclear Factor-Kappa B Signaling Pathway.
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1.
Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.
Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response.
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
splitSMLM, a spectral demixing method for high-precision multi-color localization microscopy applied to nuclear pore complexes.
Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway.
Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells.
OL-FS13 alleviates experimental cerebral ischemia-reperfusion injury.
African swine fever virus pE301R negatively regulates cGAS-STING signaling pathway by inhibiting the nuclear translocation of IRF3.
Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.
Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease.
Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy.
Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation.
Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells.
eIF4A3 Promotes RNA Viruses' Replication by Inhibiting Innate Immune Responses.
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
BP5 alleviates endotoxemia-induced acute lung injury by activating Nrf2 via dual regulation of the Keap1-Nrf2 interaction and the Akt (Ser473)/GSK3β (Ser9)/Fyn pathway.
Repeated Administration of Cisplatin Transforms Kidney Fibroblasts through G2/M Arrest and Cellular Senescence.
Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.
A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator.
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism.
Characterization of phalloidin-negative nuclear actin filaments in U2OS cells expressing cytoplasmic actin-EGFP.
Calpain-1 mediates vascular remodelling and fibrosis via HIF-1α in hypoxia-induced pulmonary hypertension.
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model.
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Downregulated RRS1 inhibits invasion and metastasis of BT549 through RPL11‑c‑Myc‑SNAIL axis.
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.
High-frequency near-infrared diode laser irradiation suppresses IL-1β-induced inflammatory cytokine expression and NF-κB signaling pathways in human primary chondrocytes.
O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation.
Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia Through Activating AMPK/Nrf2 Pathway in Rats.
Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro.
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
A novel mechanism of the lncRNA PTTG3P/miR-142-5p/JAG1 axis modulating tongue cancer cell phenotypes through the Notch1 signaling.
Bergamottin promotes osteoblast differentiation and bone formation via activating the Wnt/β-catenin signaling pathway.
Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model.
Usp8 promotes tumor cell migration through activating the JNK pathway.
The cancer/testis antigen HORMAD1 mediates epithelial-mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway in lung cancer.
Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling.
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm.
Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.
Foxf2 represses bone formation via Wnt2b/β-catenin signaling.
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation.
Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation.
TXNIP knockout improves cardiac function after myocardial infarction by promoting angiogenesis and reducing cardiomyocyte apoptosis.
Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5.
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Inflammation Induced by Lipopolysaccharide and Palmitic Acid Increases Cholesterol Accumulation via Enhancing Myeloid Differentiation Factor 88 Expression in HepG2 Cells.
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis.
The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers.
PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer.
Gamma-oryzanol protects human liver cell (L02) from hydrogen peroxide-induced oxidative damage through regulation of the MAPK/Nrf2 signaling pathways.
Exposure of mouse oocytes to N,N-dimethylformamide impairs mitochondrial functions and reduces oocyte quality.
Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor-4 inhibition in hepatocellular carcinoma.
Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells.
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Oncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession.
Nucleome programming is required for the foundation of totipotency in mammalian germline development.
RFWD3 and translesion DNA polymerases contribute to PCNA modification-dependent DNA damage tolerance.
Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis.
Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity.
Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis.
Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription.
DNA Repair Factor Poly(ADP-Ribose) Polymerase 1 Is a Proviral Factor in Hepatitis B Virus Covalently Closed Circular DNA Formation.
HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury.
Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis.
Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.
Increased m6A-RNA methylation and FTO suppression is associated with myocardial inflammation and dysfunction during endotoxemia in mice.
MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis.
MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway.
Dopamine inhibits the expression of proinflammatory cytokines of microglial cells through the formation of dopamine quinone in the mouse striatum.
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Regulation of TET2 gene expression and 5mC oxidation in breast cancer cells by estrogen signaling.
Nuclear Fragility in Radiation-Induced Senescence: Blebs and Tubes Visualized by 3D Electron Microscopy.
Bombyx mori Akirin hijacks a viral peptide vSP27 encoded by BmCPV circRNA and activates the ROS-NF-κB pathway against viral infection.
PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation.
C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy.
Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.
Matrix remodeling controls a nuclear lamin A/C-emerin network that directs Wnt-regulated stem cell fate.
A Redox-Silent Analogue of Tocotrienol May Break the Homeostasis of Proteasomes in Human Malignant Mesothelioma Cells by Inhibiting STAT3 and NRF1.
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Novel stress granule-like structures are induced via a paracrine mechanism during viral infection.
Blockade of Nuclear β-Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis.
TERC suppresses PD-L1 expression by downregulating RNA binding protein HuR.
A polypeptide inhibitor of calcineurin blocks the calcineurin-NFAT signalling pathway in vivo and in vitro.
KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.
LINC02535/miR-30a-5p/GALNT3 axis contributes to lung adenocarcinoma progression via the NF- κ B signaling pathway.
Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer.
Procyanidin B2 ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription.
Nrf2 Deficiency Exacerbated CLP-Induced Pulmonary Injury and Inflammation through Autophagy- and NF-κB/PPARγ-Mediated Macrophage Polarization.
C/D box small nucleolar RNA SNORD104 promotes endometrial cancer by regulating the 2'-O-methylation of PARP1.
PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB.
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.
Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.
Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Identification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in males.
Electrostatic anti-CD33-antibody-protamine nanocarriers as platform for a targeted treatment of acute myeloid leukemia.
N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth.
The Integrated Analysis of Transcriptomics and Metabolomics Unveils the Therapeutical Effect of Asiatic Acid on Alcoholic Hepatitis in Rats.
TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.
Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway.
PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease.
Polysaccharide extract from Isatidis Radix inhibits multiple inflammasomes activation and alleviate gouty arthritis.
Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.
Protective activity of tert-butylhydroquinone against oxidative stress and apoptosis induced by glutamate agonizts in R28 cells and mice retina.
Trans-anethole ameliorates lipopolysaccharide-induced acute liver inflammation in broilers via inhibiting NF-κB signaling pathway.
The Antimicrobial Peptides Human β-Defensins Induce the Secretion of Angiogenin in Human Dermal Fibroblasts.
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH).
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
Methyltransferase Setdb1 Promotes Osteoblast Proliferation by Epigenetically Silencing Macrod2 with the Assistance of Atf7ip.
Glycosylated modification of MUC1 maybe a new target to promote drug sensitivity and efficacy for breast cancer chemotherapy.
Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling.
Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.
PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway.
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.
C1q/tumor necrosis factor-related protein 9 protects cultured chondrocytes from IL-1β-induced inflammatory injury by inhibiting NLRP3 inflammasome activation via the AdipoR1/AMPK axis.
MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13.
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κ B and PI3K/AKT Signaling In Vitro and In Vivo.
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
N-acetylcysteine promotes cyclic mechanical stress-induced osteogenic differentiation of periodontal ligament stem cells by down-regulating Nrf2 expression.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
LATS1 is a central signal transmitter for achieving full type-I interferon activity.
Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.
Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes.
Relationship between Neuroprotective Effects and Structure of Procyanidins.
Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex.
CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling.
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Golgi Phosphoprotein 3 Confers Radioresistance via Stabilizing EGFR in Lung Adenocarcinoma.
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
TLR5 Supports Development of Placental Labyrinthine Zone in Mice.
Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis.
TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer.
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.
SNX25 regulates proinflammatory cytokine expression via the NF-κB signal in macrophages.
HIV-1 Vpr protein upregulates microRNA-210-5p expression to induce G2 arrest by targeting TGIF2.
Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling.
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
RNF128 suppresses the malignancy of colorectal cancer cells via inhibition of Wnt/β-catenin signaling.
Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/β-catenin Pathway.
Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson's Disease Rats.
Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival.
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway.
Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway.
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation.
Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells.
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma.
Yangonin modulates lipid homeostasis, ameliorates cholestasis and cellular senescence in alcoholic liver disease via activating nuclear receptor FXR.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells.
Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading.
18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.
TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling.
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide.
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo.
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway in rat hippocampus.
Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells.
Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level.
Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.
Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-κB signaling pathway.
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Loss of PHLDA1 has a protective role in OGD/R-injured neurons via regulation of the GSK-3β/Nrf2 pathway.
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
G-Quadruplexes Formation at the Upstream Region of Replication Origin (OriL) of the Pseudorabies Virus: Implications for Antiviral Targets.
Cilia locally synthesize proteins to sustain their ultrastructure and functions.
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability.
MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling.
RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.
Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo.
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus.
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses.
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer.
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
6-Gingerol attenuates ventilator-induced lung injury via anti-inflammation and antioxidative stress by modulating the PPARγ/NF-κBsignalling pathway in rats.
Chromothripsis drives the evolution of gene amplification in cancer.
Protein kinase D participates in cardiomyocyte hypertrophy by regulating extracellular signal-regulated and myocyte enhancer factor 2D.
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Silibinin treatment protects human skin cells from UVB injury through upregulation of estrogen receptors.
ATF3 drives senescence by reconstructing accessible chromatin profiles.
5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expression in TET2-Deficient Erythroleukemia Cells.
Disease Modeling with Human Neurons Reveals LMNB1 Dysregulation Underlying DYT1 Dystonia.
Salubrinal Alleviates Collagen-Induced Arthritis through Promoting P65 Degradation in Osteoclastogenesis.
Localization of the WD repeat-containing protein 5 to the Virion Assembly Compartment Facilitates Human Cytomegalovirus Assembly.
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways.
MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation.
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening.
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus.
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Activation of yes-associated protein mediates sphingosine-1-phosphate-induced proliferation and migration of pulmonary artery smooth muscle cells and its potential mechanisms.
miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.
T-17, a spirostanol saponin, inhibits p53-independent proliferation and p53-dependent migration of gastric cancer cells.
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells.
Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells.
Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch.
Particulate matter promotes hyperpigmentation via AhR/MAPK signaling activation and by increasing α-MSH paracrine levels in keratinocytes.
YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L.
C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation.
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling.
Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways.
Inhibition of miR-155 alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-κB signaling.
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice.
Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.
Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model.
Polychlorinated biphenyl quinone induced the acquisition of cancer stem cells properties and epithelial-mesenchymal transition through Wnt/β-catenin.
Serotonin transporter regulation by cholesterol-independent lipid signaling.
P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.
Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma.
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway.
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway.
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.
Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1.
Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1.
Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells.
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response.
The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior.
A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.
Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model.
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases.
α-Actinin1 promotes tumorigenesis and epithelial-mesenchymal transition of gastric cancer via the AKT/GSK3β/β-Catenin pathway.
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression.
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Establishment of a GFP::LMNB1 knockin cell line (CSUi002-A-1) from a dystonia patient-specific iPSC by CRISPR/Cas9 editing.
Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP.
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway.
Fenofibrate inhibits TGF-β-induced myofibroblast differentiation and activation in human lung fibroblasts in vitro.
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Repeated neonatal sevoflurane induced neurocognitive impairment through NF-κB-mediated pyroptosis.
Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer.
Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice.
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis.
Pseudoginsenoside F11 ameliorates the dysfunction of the autophagy-lysosomal pathway by activating calcineurin-mediated TFEB nuclear translocation in neuron during permanent cerebral ischemia.
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway.
Myricetin protects against H(2) O(2) -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration.
LncRNA AC010789.1 Promotes Colorectal Cancer Progression by Targeting MicroRNA-432-3p/ZEB1 Axis and the Wnt/β-Catenin Signaling Pathway.
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Effects of Saccharides from Arctium lappa L. Root on FeCl(3)-Induced Arterial Thrombosis via the ERK/NF-κB Signaling Pathway.
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats.
Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation.
Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Reduced hydration-induced decreased caveolin-1 expression causes epithelial-to-mesenchymal transition.
Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma.
Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo.
Linalool Prevents Cisplatin Induced Muscle Atrophy by Regulating IGF-1/Akt/FoxO Pathway.
Repositioning an Immunomodulatory Drug Vidofludimus as a Farnesoid X Receptor Modulator With Therapeutic Effects on NAFLD.
Lycopene Exerts Neuroprotective Effects After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the Nuclear Factor Erythroid-2 Related Factor 2/Nuclear Factor-κ-Gene Binding Pathway.
Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins.
Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway.
Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication.
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma.
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3.
Tacrolimus ameliorates tubulointerstitial inflammation in diabetic nephropathy via inhibiting the NFATc1/TRPC6 pathway.
Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Circular RNA GLIS2 promotes colorectal cancer cell motility via activation of the NF-κB pathway.
Facile Cholesterol Loading with a New Probe ezFlux Allows for Streamlined Cholesterol Efflux Assays.
Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies.
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.
Down-regulation of exosomal miR-200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis.
RNA demethylase Alkbh5 is widely expressed in neurons and decreased during brain development.
Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation.
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis.
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production.
Aryl hydrocarbon receptor signaling activation in systemic sclerosis attenuates collagen production and is a potential antifibrotic target.
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence.
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Pin1 promotes pancreatic cancer progression and metastasis by activation of NF-κB-IL-18 feedback loop.
DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/ Polyps with Dysplasia.
Regulation of a PRMT5/NF-κB Axis by Phosphorylation of PRMT5 at Serine 15 in Colorectal Cancer.
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics.
Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury.
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Nuclear-localized costimulatory molecule 4-1BBL promotes colon cancer cell proliferation and migration by regulating nuclear Gsk3β, and is linked to the poor outcomes associated with colon cancer.
Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression.
[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin.
AEBP1 Promotes the Occurrence and Development of Abdominal Aortic Aneurysm by Modulating Inflammation via the NF-κB Pathway.
1,25-Dihydroxyvitamin D attenuates diabetic cardiac autophagy and damage by vitamin D receptor-mediated suppression of FoxO1 translocation.
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Novel role of ASH1L histone methyltransferase in anaplastic thyroid carcinoma.
RGS12 Is a Novel Critical NF-κB Activator in Inflammatory Arthritis.
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
SIRT2 suppresses expression of inflammatory factors via Hsp90-glucocorticoid receptor signalling.
The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction.
EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer.
Deficiency of microRNA-628-5p promotes the progression of gastric cancer by upregulating PIN1.
Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia.
Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling.
Poly (ADP-ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation-associated chemotherapy-induced autophagy in leukaemia cells.
USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells.
The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry.
Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter.
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas.
Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease.
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.
A DNAH17 missense variant causes flagella destabilization and asthenozoospermia.
UBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma.
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl(4)-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-κB pathway.
Promotion of esophageal adenocarcinoma metastasis via Wnt/ß-catenin signal pathway by sorting nexins 3.
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Peroxisome proliferator activated receptor γ promotes mineralization and differentiation in cementoblasts via inhibiting Wnt/β-catenin signaling pathway.
Expressional Localization and Functionally Identifying an RNA Editing Enzyme BmADARa of the Silkworm Bombyx mori.
GADD45G Interacts with E-cadherin to Suppress the Migration and Invasion of Esophageal Squamous Cell Carcinoma.
Ribosome profiling analysis identified a KRAS-interacting microprotein that represses oncogenic signaling in hepatocellular carcinoma cells.
A novel Sprouty4-ERK1/2-Wnt/β-catenin regulatory loop in marrow stromal progenitor cells controls osteogenic and adipogenic differentiation.
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.
SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia.
Interleukin-17 suppresses grass carp reovirus infection in Ctenopharyngodon idellus kidney cells by activating NF-κB signaling.
Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.
p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma.
LncRNA SNHG16 promotes epithelial- mesenchymal transition via down-regulation of DKK3 in gastric cancer.
Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats.
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Nuclear CD44 Mediated by Importin β Participated in Naïve Genes Transcriptional Regulation in C3A-iCSCs.
Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes.
Revealing Antidepressant Mechanisms of Baicalin in Hypothalamus Through Systems Approaches in Corticosterone- Induced Depressed Mice.
Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells.
The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster.
DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS.
Leptin-Induced Angiogenesis of EA.Hy926 Endothelial Cells via the Akt and Wnt Signaling Pathways In Vitro and In Vivo.
Aerobic Exercise Improves Synaptic-Related Proteins of Diabetic Rats by Inhibiting FOXO1/NF-κB/NLRP3 Inflammatory Signaling Pathway and Ameliorating PI3K/Akt Insulin Signaling Pathway.
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma.
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
A hidden human proteome encoded by 'non-coding' genes.
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
AEBP1, a prognostic indicator, promotes colon adenocarcinoma cell growth and metastasis through the NF-κB pathway.
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Follicle-stimulating hormone promotes renal tubulointerstitial fibrosis in aging women via the AKT/GSK-3β/β-catenin pathway.
Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury.
P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Arsenic trioxide inhibits angiogenesis in vitro and in vivo by upregulating FoxO3a.
TMEM18 inhibits osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells by inactivating β-catenin.
Type I collagen or gelatin stimulates mouse peritoneal macrophages to aggregate and produce pro-inflammatory molecules through upregulated ROS levels.
The protective effects of L-carnitine on myocardial ischaemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-κB pathway and the activation of Nrf2 pathway.
Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism.
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion.
DYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild-type NSCLC cells to AZD9291.
Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway.
Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa B signaling pathway.
ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma.
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy.
Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy.
Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels.
A cellular model for Wilson's disease using patient-derived induced pluripotent stem cells revealed aberrant β-catenin pathway during osteogenesis.
Ginsenoside Rk3 ameliorates high-fat-diet/streptozocin induced type 2 diabetes mellitus in mice via the AMPK/Akt signaling pathway.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Sodium ferulate protects against influenza virus infection by activation of the TLR7/9-MyD88-IRF7 signaling pathway and inhibition of the NF-κB signaling pathway.
Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.
Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation.
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia.
Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence.
Discovery of human TyrRS inhibitors by structure-based virtual screening, structural optimization, and bioassays.
In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways.
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells.
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells.
IL-1β receptor antagonist (IL-1Ra) combined with autophagy inducer (TAT-Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes.
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells.
Attenuation of Atherosclerosis by Protocatechuic Acid via Inhibition of M1 and Promotion of M2 Macrophage Polarization.
The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest.
Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model.
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.
Anacardic acid inhibits RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced bone loss in vivo.
The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors.
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia.
Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling.
High-mobility group box 1 protein modulated proliferation and radioresistance in esophageal squamous cell carcinoma.
Knockdown of Golgi phosphoprotein 73 blocks the trafficking of matrix metalloproteinase-2 in hepatocellular carcinoma cells and inhibits cell invasion.
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner.
Glycyrrhizin Protects Mice Against Experimental Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1 (HMGB1) Expression and Neuronal HMGB1 Release.
An Immunosuppressive Tick Salivary Gland Protein DsCystatin Interferes With Toll-Like Receptor Signaling by Downregulating TRAF6.
Overexpression of β-Catenin Decreases the Radiosensitivity of Human Nasopharyngeal Carcinoma CNE-2 Cells.
Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice.
Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway.
Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells.
Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets.
IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3.
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.
Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus.
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Astrocyte elevated gene-1 participates in the production of pro-inflammatory cytokines in dental pulp cells via NF-κB signalling pathway.
Comparison of the Effects and Inhibitory Pathways of the Constituents from Gynostemma pentaphyllum against LPS-Induced Inflammatory Response.
Salvianolic Acid B-Alleviated Angiotensin II Induces Cardiac Fibrosis by Suppressing NF-κB Pathway In Vitro.
ERα is a negative regulator of PD-L1 gene transcription in breast cancer.
Dynamic changes of proteasome and protective effect of bortezomib, a proteasome inhibitor, in mice with acute pancreatitis.
TRPV2-induced Ca(2+)-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.
PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation.
Redox-active trace metal-induced release of high mobility group box 1(HMGB1) and inflammatory cytokines in fibroblast-like synovial cells is Toll-like receptor 4 (TLR4) dependent.
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Tetrachlorobenzoquinone-Induced Nrf2 Confers Neuron-like PC12 Cells Resistance to Endoplasmic Reticulum Stress via Regulating Glutathione Synthesis and Protein Thiol Homeostasis.
Polybrominated Diphenyl Ethers Quinone Induced Parthanatos-like Cell Death through a Reactive Oxygen Species-Associated Poly(ADP-ribose) Polymerase 1 Signaling.
Follicle-stimulating hormone enhances hepatic gluconeogenesis by GRK2-mediated AMPK hyperphosphorylation at Ser485 in mice.
Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways.
Folic acid supplementation repressed hypoxia-induced inflammatory response via ROS and JAK2/STAT3 pathway in human promyelomonocytic cells.
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos.
Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells.
Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Exosomes from C2C12 myoblasts enhance osteogenic differentiation of MC3T3-E1 pre-osteoblasts by delivering miR-27a-3p.
Calpain and JNK pathways participate in isoflurane - induced nucleus translocation of apoptosis-inducing factor in the brain of neonatal rats.
PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein.
Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling.
Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor.
Excessive endoplasmic reticulum stress and decreased neuroplasticity-associated proteins in prefrontal cortex of obese rats and the regulatory effects of aerobic exercise.
Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway.
Fam83h mutation inhibits the mineralization in ameloblasts by activating Wnt/β-catenin signaling pathway.
Long noncoding RNA lncARSR promotes hepatic cholesterol biosynthesis via modulating Akt/SREBP-2/HMGCR pathway.
An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness.
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
Sub-lethal ultraviolet B irradiation and Poly I:C treatment synergistically induced apoptosis of HaCaT cells through NF-κB pathway.
Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinoma.
Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation.
Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats.
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Activation of peroxisome proliferation-activated receptor-γ inhibits transforming growth factor-β1-induced airway smooth muscle cell proliferation by suppressing Smad-miR-21 signaling.
PTEN-L promotes type I interferon responses and antiviral immunity.
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
IRF1 up-regulates isg15 gene expression in dsRNA stimulation or CSFV infection by targeting nucleotides -487 to -325 in the 5' flanking region.
Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway.
LINC01016 promotes the malignant phenotype of endometrial cancer cells by regulating the miR-302a-3p/miR-3130-3p/NFYA/SATB1 axis.
The interactome and spatial redistribution feature of Ca(2+) receptor protein calmodulin reveals a novel role in invadopodia-mediated invasion.
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.
Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway.
Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling.
PNMA1, regulated by miR-33a-5p, promotes proliferation and EMT in hepatocellular carcinoma by activating the Wnt/β-catenin pathway.
The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response.
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells.
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.
The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation.
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway.
Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration.
TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3.
Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ.
Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.
Necrostatin-1 attenuates early brain injury after subarachnoid hemorrhage in rats by inhibiting necroptosis.
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
CDKL1 promotes tumor proliferation and invasion in colorectal cancer.
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling.
Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.
Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats.
Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms.
Cooperative regulation of Gja1 expression by members of the AP-1 family cJun and cFos in TM3 Leydig and TM4 Sertoli cells.
2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Overexpression of Rsf-1 correlates with poor survival and promotes invasion in non-small cell lung cancer.
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
E-Prostanoid 3 Receptor Mediates Sprouting Angiogenesis Through Suppression of the Protein Kinase A/β-Catenin/Notch Pathway.
Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages.
Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells.
Nrf2-Knockout Protects from Intestinal Injuries in C57BL/6J Mice Following Abdominal Irradiation with γ Rays.
Correction: Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells.
The electrophilic character of quinones is essential for the suppression of Bach1.
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining.
Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer.
The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins.
Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells.
Repression of YAP by NCTD disrupts NSCLC progression.
The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling.
A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury.
Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.
Respiratory Syncytial Virus Nonstructural Protein 1 Blocks Glucocorticoid Receptor Nuclear Translocation by Targeting IPO13 and May Account for Glucocorticoid Insensitivity.
Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells.
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.
Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.
Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.
Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma.
The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway.
Toll-like receptor 2-mediated MAPKs and NF-κB activation requires the GNAO1-dependent pathway in human mast cells.
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
The absence of p53 during Human Cytomegalovirus infection leads to decreased UL53 expression, disrupting UL50 localization to the inner nuclear membrane, and thereby inhibiting capsid nuclear egress.
From the Cover: Tetrachlorobenzoquinone Exerts Neurological Proinflammatory Activity by Promoting HMGB1 Release, Which Induces TLR4 Clustering within the Lipid Raft.
Salusin-β contributes to vascular inflammation associated with pulmonary arterial hypertension in rats.
Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.
P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.
AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation.
Go is required for the release of IL-8 and TNF-α, but not degranulation in human mast cells.
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons.
Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation.
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes.
Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IκB/NF-κB signaling.
PRELP (proline/arginine-rich end leucine-rich repeat protein) promotes osteoblastic differentiation of preosteoblastic MC3T3-E1 cells by regulating the β-catenin pathway.
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways.
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.
The E3 Ubiquitin Ligase c-Cbl Inhibits Microglia-Mediated CNS Inflammation by Regulating PI3K/Akt/NF-κB Pathway.
Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein.
Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells.
A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha.
Identification and characterization of an endoplasmic reticulum localization motif.
Mechanistic Study of the Phytocompound, 2- β -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches.
The Overexpression of IQGAP1 and β-Catenin Is Associated with Tumor Progression in Hepatocellular Carcinoma In Vitro and In Vivo.
Demethylzeylasteral (T-96) Treatment Ameliorates Mice Lupus Nephritis Accompanied by Inhibiting Activation of NF-κB Pathway.
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver.
miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.
Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma.
Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells.
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
The effects of focal adhesion kinase on the motility, proliferation and apoptosis of Caco2 and SMMC-7721 cells.
WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis.
Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3.
CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDAC1-associated repression of C/EBPα.
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
Role of α-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis.
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/β-catenin signaling pathway.
Pao Pereira Extract Suppresses Castration-Resistant Prostate Cancer Cell Growth, Survival, and Invasion Through Inhibition of NFκB Signaling.
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro.
Vascular endothelial growth factor receptor-1 activation promotes migration and invasion of breast cancer cells through epithelial-mesenchymal transition.
Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L.
Conditioned medium of Wnt/β-catenin signaling-activated olfactory ensheathing cells promotes synaptogenesis and neurite growth in vitro.
Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model.
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
Adeno-associated virus Rep78 restricts adenovirus E1B55K-mediated p53 nuclear exportation.
Induction of apoptosis in infantile hemangioma endothelial cells by propranolol.
Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation.
1,2,3,4,6-penta-O-galloyl-β-D-glucose protects PC12 Cells from MPP(+)-mediated cell death by inducing heme oxygenase-1 in an ERK- and Akt-dependent manner.
Hypoxia increases CX3CR1 expression via HIF-1 and NF‑κB in androgen-independent prostate cancer cells.
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
Activation of the Wnt/β-catenin signaling pathway is associated with glial proliferation in the adult spinal cord of ALS transgenic mice.
Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kappaB AND AP-1 through inhibition of MAPKS and AKT/IkappaBalpha signaling pathways in macrophages.
KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways.
Jin W, Wu Y, Cheng X, Pan Y, He L, Xu Y, Xu J, Zhang X
Mediators of inflammation 2026;2026:5486971
Mediators of inflammation 2026;2026:5486971
PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment.
Chen H, Hu X, Feng L, Cheng X, Zhu L, Xu F, Zhu T, Gao Y, Wang J, Jin H, Jiang Z
Oncogene 2026 May;45(19):1756-1770
Oncogene 2026 May;45(19):1756-1770
Periplogenin Suppresses Hepatocarcinogenesis by Inducing Cellular Senescence via the Activating FOXO1/P53 Signaling Pathway.
Wang P, Zhu J, Li W, He Z, Dai X, Shi Y, Xu Z, Wang P, Wang R, Chen J, Liang R, Huang J, Jiang Y, Chen G, Chen H, Xie X
Phytotherapy research : PTR 2026 May;40(5):2588-2603
Phytotherapy research : PTR 2026 May;40(5):2588-2603
LDHA protects vascular endothelial cells from oxidative stress‑induced mitochondrial damage via HIF‑1α activation and glycolytic reprogramming.
Dai B, Yang L, Zhang Y, Yu A
Molecular medicine reports 2026 May;33(5)
Molecular medicine reports 2026 May;33(5)
BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer-Associated Fibroblasts Crosstalk.
Shi HZ, Wu MY, Liu JQ, Tian C, Ma L, Zhou XM, Sun ZH, Xu ZY, Zhang RD, Ye SY, Huang LM, Wang Y, Xiong JS, Bu WB, Cheng XF, Sun JF, Chen H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(28):e14590
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(28):e14590
Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol-Induced Intestinal Injury via Microbiota-Dependent and -Independent AHR Activation.
Cui C, Zhang B, Tang J, Hou J, Qiu Y, Gao K, Wang L, Jiang Z, Yang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e22912
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e22912
An HHEX/IKKα positive feedback loop promotes intestinal inflammation.
Hua Z, Xu W, Ding W, Fu Z, Wang Y, Yang Y, Liu F, Dai Z, Tang W, Ou W, Ge W, Chen Y, Wang Z, Liu CY, Du P
The Journal of clinical investigation 2026 May 15;136(10)
The Journal of clinical investigation 2026 May 15;136(10)
GGC repeat expansions within new open reading frames are translated into toxic polyglycine proteins in oculopharyngodistal myopathy.
Boivin M, Yu J, Eura N, Schmitt L, Pietri D, Grandgirard E, Goetz-Reiner P, Plassard D, Nahy C, Maglott A, Morlet B, Gao C, Lefebvre E, Philipps M, Eberling P, Pichot A, Rossolillo P, Thibault C, Oulad-Abdelghani M, Nishino I, Yang K, Wang N, Wang Z, Deng J, Charlet-Berguerand N
Nature genetics 2026 Mar;58(3):517-529
Nature genetics 2026 Mar;58(3):517-529
Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity.
Li Y, Zheng M, Zhu Z, Zhang Y, Ning P, Chen H, Gao R, Xu C, Wei X, Liu Y, Wang Y, Zhou R, Li Y, Li Z, Lv C, Liu C, Xu J, Guo Z, Hu Z, Fang L, Wei K, Feng M, Zhou C, She Y, Sun W, Chen E, Plaza GR, He B, Miska J, Yang W, Tang Y, Liu H, Chen C, Cheng Y
Cell research 2026 Mar;36(3):197-218
Cell research 2026 Mar;36(3):197-218
Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications.
Dong D, Sun Y, Sui Q, Zhao Z, Ma H, Li K, Yu X
Inflammopharmacology 2026 Mar;34(3):1973-1990
Inflammopharmacology 2026 Mar;34(3):1973-1990
Histatin-1 promotes bone regeneration by coordinating osteogenic and angiogenic responses in a sustained-release hydrogel system.
Zhu Y, Lou Y, Zhang M, Sun J, Zhang B, Ye Y, Li Z, Lu J, Wan B, Wu G, Li Q, Sun P
Biomaterials advances 2026 Mar;180:214618
Biomaterials advances 2026 Mar;180:214618
Crebanine protects against ovariectomy-induced bone loss by targeting Sirt1 to interfere with NF-κB acetylation and ROS activity.
Zhang H, Zhao X, Wang Z, Miao J, Hu X, Cui P, Jin C, Zhao X, Liang H, Ye H, Xu Y, Chen X, Wang W, Lu S
Journal of pharmaceutical analysis 2026 Mar;16(3):101426
Journal of pharmaceutical analysis 2026 Mar;16(3):101426
Qiangjing Tablets modulate oxidative stress and endoplasmic reticulum stress through the PI3K/Akt/NRF-2 signaling axis and regulate gut microbiota in ornidazole-induced asthenozoospermia rats.
Li G, Gao D, Chang D, Zhang P, Ma Z, Chen D, Gao X, Ye N, Huang X, You Y
Journal of traditional and complementary medicine 2026 Mar;16(2):178-190
Journal of traditional and complementary medicine 2026 Mar;16(2):178-190
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development.
Liu X, Xie L, Jin Y, Chen S, Shi X, Zong Y, Zhao Z, Kong WJ, Sun Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e14136
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e14136
SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING.
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B
The Journal of general virology 2026 Mar;107(3)
The Journal of general virology 2026 Mar;107(3)
Kukoamine B Inhibits EMT in Lung Adenocarcinoma Cells by Regulating Intracellular PD-L1-Mediated p65 Nuclear Translocation.
Hou C, Chen J, Zhang L, Huang Q, Xu J, Zhang R, He Y
Biology 2026 Mar 6;15(5)
Biology 2026 Mar 6;15(5)
NOX1/4 drives hepatic iron and lipid dysregulation, redox imbalance, and inflammation in ethanol-fed mice.
Yu L, He T, Zhang P, Zhao X, Xun L, Li R, Wan P
Scientific reports 2026 Mar 5;16(1)
Scientific reports 2026 Mar 5;16(1)
ECM-Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling.
Packirisamy S, André O, Fan Z, Nordenfelt P, Swaminathan VS
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e17631
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e17631
IL-3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury.
Huang N, Zhang Q, Chen Y, Yu D, Liu R, Kang J, Fang X, Zhang Y, Bian H, Zhao Y, Yin Y, Zhang C, Jia Y, Chen Q, Fang Y, Li S, Li F, Jin Z, Ning B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e04511
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e04511
RUNX1 restrains STAT1-GITRL signaling to shape an immunosuppressive CRC microenvironment.
He W, Zheng L, Huang W, Li K, Chen Y, Zeng R, Lin Z, Xu Y, Hu S, Zhang Q
Cell death discovery 2026 Mar 25;12(1)
Cell death discovery 2026 Mar 25;12(1)
Myeloid-Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis.
Zhou M, Xiao Y, Xu Z, Yang C, Li J, Liu Y, Yin P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 25;:e19267
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 25;:e19267
CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma.
Cao Y, Xu C, Liu Y, Shi B, Li X, Li J, Zhang B, Zhang Z, Dai S, Sun Q, Gu J
iScience 2026 Mar 20;29(3):114840
iScience 2026 Mar 20;29(3):114840
NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4.
Zhuang Z, Guan B, Wang Y, Lin X, Cai H, Chen B, Li S, Liu X, Zhuang J, Guan G
Cellular oncology (Dordrecht, Netherlands) 2026 Mar 18;49(2)
Cellular oncology (Dordrecht, Netherlands) 2026 Mar 18;49(2)
Nitrogen cavitation enables rapid and high-yield preparation of functional cell-membrane-derived vesicles.
Li C, Luo D, Peng C, Luo Q, Xu W, Zhou J, Su W, Wu W, Wang YF
Nanoscale advances 2026 Mar 17;8(6):2021-2030
Nanoscale advances 2026 Mar 17;8(6):2021-2030
Prophylactic isoimperatorin protects against LPS-ALI via mTOR-dependent control of inflammation, oxidative stress and ferroptosis markers.
Zhang J, Zhang Z, Cui T, Tang X, Li J, Ma C, Chen T, Wu X, Qiu M, Wang D, Cui Z, Zuo H, Xu L, Liu W, Zhao W, Yin L, Xing Z, Zhang Y, Ke J, Yang X, Wang Q
Journal of ethnopharmacology 2026 Mar 1;358:120998
Journal of ethnopharmacology 2026 Mar 1;358:120998
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Zhang K, Sun S, Qiu H, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2026 Mar 1;358:120981
Journal of ethnopharmacology 2026 Mar 1;358:120981
Phosphoethanolamine cytidylyltransferase 2 exerts an anti-tumor role in clear cell renal cell carcinoma by modulating the hippo/YAP1 signaling pathway in a PPP2R1A-dependent manner.
Nan N, Guo H, Huang Y, Chen J, Qiang X
Toxicology and applied pharmacology 2026 Jun;511:117786
Toxicology and applied pharmacology 2026 Jun;511:117786
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Wang J, Chen P, Li Y, Wang R, Ding W, Yu R, Qin Q, Wu R, Wei W, Shi J, Yuan H, Zhuang C, Sun Y
Free radical biology & medicine 2026 Jun;249:165-179
Free radical biology & medicine 2026 Jun;249:165-179
Baimaside, a flavonoid glycoside from Apocynum venetum, ameliorates sepsis by allosterically inhibiting NF-κB p50-mediated IL-6 transcription.
Zhang Y, Li W, Liang Y, Zang L, Chen X, Xiong X, Zhang S, Li Y, Qu X, Geng J, Xin Y
Biochemical pharmacology 2026 Jun;248:117868
Biochemical pharmacology 2026 Jun;248:117868
Polystyrene nanoplastics promote adipogenesis by stimulating nuclear translocation of PPARγ.
Zheng Y, Liu Z, Zhao Z, Sheng C, Li W, Tang D, Ning Y, Zhou R, Li A, Zhou Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jun;212:116030
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jun;212:116030
HIF-1α drives pyroptosis in extravillous trophoblasts by suppressing PPAR-γ to activate the NLRP3 inflammasome in RA-complicated pregnancy.
Zhang T, Zhao Y, He W, Chen Y, Liu Q, Tang Y, Geng S, Xu L, Tao L, Yu Z, Zhang X, Yang Y, Zhao J, Zhang L
International immunopharmacology 2026 Jun 1;178:116522
International immunopharmacology 2026 Jun 1;178:116522
Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis.
Liu S, Ru K, Shen YJ, Yan Y, Zhu C, Wang H, Xu Y, Wang X, Yang H, Zhao S, Gong Y, Tian Y, Qian A, Yang H, Chen Z
Free radical biology & medicine 2026 Jul;250:284-297
Free radical biology & medicine 2026 Jul;250:284-297
Zinc deficiency exacerbates and supplementation attenuates early-stage obesity-related podocyte injury via Nrf2/HO-1-mediated pyroptosis.
Guan Y, Li Y, Bai X, Luo P, Luo M
International immunopharmacology 2026 Jul 1;180:116703
International immunopharmacology 2026 Jul 1;180:116703
Dimethyl fumarate alleviates oxidative stress and inflammation in noise-induced hearing loss by activating Nrf2/HO-1 signaling in cochlear hair cells.
Li M, Zhang W, Huang X, Fu M, Zhang J, Chen J, Pang J, Yang H
International immunopharmacology 2026 Jul 1;180:116675
International immunopharmacology 2026 Jul 1;180:116675
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production.
Li X, Xiang Z, Wang X, He H, Xu M, Tan C, Wu X, Zhang J, Dong W
Journal of advanced research 2026 Jan;79:393-407
Journal of advanced research 2026 Jan;79:393-407
6-Gingerol alleviates NNK-induced lung carcinogenesis by boosting antioxidation and reducing inflammation.
Qu Z, Ding Y, Zhang L, Sun J, Wang T, Zhuang C
Free radical research 2026 Jan;60(1):1-15
Free radical research 2026 Jan;60(1):1-15
YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice.
Cen J, Yu X, Wang Z, Liu W, Xu J, Fang Q, Gao F, Cao Y, Liu H
Cell proliferation 2026 Jan;59(1):e70079
Cell proliferation 2026 Jan;59(1):e70079
Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis.
Sun W, Liao Y, Feng J, Liang J, He Q, Cui Y, Huang D, Shi H, You W, Sun W, Yi Q
International journal of molecular medicine 2026 Jan;57(1)
International journal of molecular medicine 2026 Jan;57(1)
Ononin induces ferroptosis in colorectal cancer cells via the PI3K/AKT/Nrf2 pathway to enhance anti-cancer immunotherapy.
Gui Y, Deng S, Li J, Zuo D, Fan H
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):421-439
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):421-439
Structural characterization and multi-omics analysis of novel Saposhnikovia divaricata (Turcz.) Schischk acidic heteropolysaccharide alleviating acute liver injury.
Sun X, Zhang T, Zhu W, Jiang X, Wang S, Zhao Y, Bian X
International journal of biological macromolecules 2026 Jan;339(Pt 1):149819
International journal of biological macromolecules 2026 Jan;339(Pt 1):149819
Circadian Clock Dysfunction Exacerbate Autistic-Like Behaviour and Wnt/β-Catenin Signalling Dysregulation in ASD Mice and Treatment of Melatonin.
Zhang Y, Chen Y, Li W, Tang L, Wang G, Li J, Feng X
Journal of cellular and molecular medicine 2026 Jan;30(1):e70991
Journal of cellular and molecular medicine 2026 Jan;30(1):e70991
Eugenol attenuates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the Nrf2/GPX4 pathway.
Sun S, Lu X, Yang S, Liang H, Lyu G, Chen Y, Yu L, Gao Z, Wang J, Xiao P, Jin L, Huang C, Wang X
Free radical biology & medicine 2026 Jan;242:508-520
Free radical biology & medicine 2026 Jan;242:508-520
Molecular-scale isotropic 3D super-resolution microscopy via interference localization.
Luo S, Zhao X, Li Y, Fan C, Liu R, Gong R, Li W, Ma N, Yang Z, Xu T, Ji W, Gu L
Nature methods 2026 Jan;23(1):183-192
Nature methods 2026 Jan;23(1):183-192
A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer.
Cui S, Luo X, Fan G, Jiang J, Wang Y, Yang E, Ma J, Zhang Z, Wang Y, Wang J, Wang D, Wang H, Cheng L, Tian J, Dong Z, Liu Y, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e09933
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e09933
Early growth response 1 promotes RNA polymerase I-directed transcription and cancer growth by activating RRN3 expression.
Song X, Xia W, Zhang J, Wu Z, Zeng H, Yang Y, Wang Y, Yu D, Zhao S, Guo B, Deng W
Communications biology 2026 Jan 9;9(1):209
Communications biology 2026 Jan 9;9(1):209
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
Zhang N, Zhao R, Zhong X, Dong Q, Liu Y, Yu K, Han L, Meng F, Wu J, Chen Q, Li X, Chen Q, Zhang K, Huang H, Zhang J, Wu S, Ren Y, Wang W, Liu Y
Nature communications 2026 Jan 8;17(1):1406
Nature communications 2026 Jan 8;17(1):1406
STT3A-mediated FCN3 N-glycosylation promotes Treg cell activation to drive hepatocellular carcinoma progression via Wnt/β-catenin.
Zhang H, Zhang P, Gong T, Zhang C, Wang Z, Zhao Y
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 6;49(1):16
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 6;49(1):16
CDK5RAP3 Regulates Testosterone Production in Mouse Leydig Cells.
Ruan J, Dong Q, Jin Y, Yang Y, Li J, Cai Y
International journal of molecular sciences 2026 Jan 6;27(2)
International journal of molecular sciences 2026 Jan 6;27(2)
Sensitising PDAC to Gemcitabine by Suppressing NF-κB Pathway and Enhancing Apoptosis.
Jin E, Simões MRGDS, O'Hagan S, Jin E, Day PJ
Pharmaceuticals (Basel, Switzerland) 2026 Jan 30;19(2)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 30;19(2)
Epicatechin Gallate Ameliorates UVB-Induced Photoaging by Inhibiting p38α-Mediated Autophagy and Oxidative Stress.
Yang D, Sun R, Cui Y, Li Y, Hou H, Otsuki K, Li W, Xu J, Zhang P, Zhang J
Antioxidants (Basel, Switzerland) 2026 Jan 30;15(2)
Antioxidants (Basel, Switzerland) 2026 Jan 30;15(2)
The Taurine-Slc6a6 Axis Promotes Breast Cancer Progression by Alleviating Oxidative Stress and Accelerating Cell Cycle Progression.
Cai P, Liu X, Lin M, Xie S, Yuan L, Lin Z, Zhang Y, Cai S
Cells 2026 Jan 22;15(2)
Cells 2026 Jan 22;15(2)
Nuclear activities and interactome of the NS5 protein of Tick-Borne Encephalitis Virus.
Chazal M, Sow AA, Le Seac'h E, Hawasheen D, Bonifacio M, Feracci M, Gracias S, Sogues A, Molho M, Pan H, Bonaventure B, Quivy JP, Almouzni G, Decroly E, Ramage H, Johnson JR, Caval V, Jouvenet N
bioRxiv : the preprint server for biology 2026 Jan 21;
bioRxiv : the preprint server for biology 2026 Jan 21;
Trichostatin A Influences Dendritic Cells' Functions by Regulating Glucose and Lipid Metabolism via PKM2.
Yang X, Men L, Guo Y, Duan L, Yu M, Zhang L, Song T, Li X, Chen X
Molecules (Basel, Switzerland) 2026 Jan 16;31(2)
Molecules (Basel, Switzerland) 2026 Jan 16;31(2)
CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity.
Wang DM, Yang J, Ansari MO, Arbieva Z, Maienschein-Cline M, Natarajan V, Malik AB, Tiruppathi C
iScience 2026 Jan 16;29(1):114255
iScience 2026 Jan 16;29(1):114255
Targeting sorting nexin 3 to treat pulmonary fibrosis by dual modulating Wnt/β-catenin signaling.
Ma D, Yu W, Zhou H, Lin R, Sun X, Peng M, Lin C, Du H, Li Y, Liang H, Sun D, Liu P, Lu J
Cell death & disease 2026 Jan 15;17(1):43
Cell death & disease 2026 Jan 15;17(1):43
Bioswitchable intracellular delivery of small activating RNA by tetrahedral framework nucleic acid: Application to p21-mediated anti-tumor therapy.
Liu Y, Lin S, Liang L, Cai Z, Zhuang W, Chen X, Gao L, Li S, Lin Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114488
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114488
SBF-1 suppresses colorectal cancer cell growth via modulating cholesterol metabolic reprogramming.
Liang X, Lu L, Wang N, Yu B, Xu Q, Luo Q
Biochemical and biophysical research communications 2026 Jan 1;794:153046
Biochemical and biophysical research communications 2026 Jan 1;794:153046
Forsythoside B protects cartilage and subchondral bone in osteoarthritis by regulating the Nrf2/NF - κ B signaling pathway.
Zhang H, He Z, Wang H, Lu F, Chen H
International immunopharmacology 2026 Jan 1;168(Pt 1):115762
International immunopharmacology 2026 Jan 1;168(Pt 1):115762
Piezo1 mediated scaffold-free rapid generation of self-mineralized bone organoids via activating Wnt signaling.
Zhang L, Zhang Y, Wan Z, Yuan X, Gao Y, Song R, Liu X, Sang J, Song J, Wang Y, Zhao Y, Yuan Z
Materials today. Bio 2026 Feb;36:102620
Materials today. Bio 2026 Feb;36:102620
CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation.
Shao Q, Zhang J, Wang H
Molecular medicine reports 2026 Feb;33(2)
Molecular medicine reports 2026 Feb;33(2)
Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini-chromosome maintenance complex and causes DNA damage.
Tsuyama T, Takayama N, Tanaka R, Arai Y, Yamaguchi Y, Nawata Y, Azuma Y, Tada S
FEBS open bio 2026 Feb;16(2):352-364
FEBS open bio 2026 Feb;16(2):352-364
A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening.
Nakao Y, Mori M, Sekiguchi Y, Morita I, Shindoh R, Mandai S, Fujiki T, Kikuchi H, Ando F, Susa K, Mori T, Suzuki A, Nashimoto Y, Kaji H, Waseda Y, Yoshida S, Fujii Y, Sohara E, Uchida S, Miyake K, Mori Y
Advanced healthcare materials 2026 Feb;15(7):e01795
Advanced healthcare materials 2026 Feb;15(7):e01795
High-fat diet mediates the formation of nonalcoholic fatty liver by modulating the AhR/miR-132/SIRT1 axis.
Tao Q, Xie J, Zhou Y, Wu Y, Xia H, Wang J, Zhang C, Wei C, Jin Y
The Journal of nutritional biochemistry 2026 Feb;148:110174
The Journal of nutritional biochemistry 2026 Feb;148:110174
Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy.
Li Y, Jia Z, Liu X, Xia X, Zhang L, Dai H, Li S, Zhou Y, Ma L, Bai Z
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):71
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):71
LncRNA AC098613.1 promotes acute myeloid leukemia cell differentiation through CDC5L/ADAP1/NRD1 axis.
Jiang Q, Wang X, Yao H, Wang J, Tang P, Liang M, Pan Z, Li B, Lin C, Wu Q, Wang Q, Zheng Q, Kuok CF, Liu H, Sun C, Li D
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):67
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):67
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
Zhang H, Zhang D, Wang Z, Liu K, Xu C, Sun H, Yan Z, Li C, Lu B, Yin Y, Zhao C, Niu Y, Li W
Biology direct 2026 Feb 26;21(1)
Biology direct 2026 Feb 26;21(1)
ELK1 suppressed the progression of vascular dementia via modulating mTOR/CREB/YAP/TFEB signaling induced ferroptosis in hippocampal cells.
Xu J, Liu M, Qi Q, An J, Xiao Y, Guan T, Teng Z, Chen W, Li R, Dong Y, Chang Y, Lu P
Scientific reports 2026 Feb 26;16(1)
Scientific reports 2026 Feb 26;16(1)
Dipsacoside B alleviates aflatoxin B1-induced liver injury in mice.
Li S, Zhang M, Wang B, Liang G, Li X
Mycotoxin research 2026 Feb 21;42(2)
Mycotoxin research 2026 Feb 21;42(2)
DNMT2 inhibits anaplastic thyroid cancer progression by downregulating 5'tiRNA(Gly-GCC) production.
Zhou R, Li B, Cao M, Wu Z, Xia F, Li X
Cell death & disease 2026 Feb 21;17(1)
Cell death & disease 2026 Feb 21;17(1)
Ganoderma lucidum Polysaccharide Potentiates mRNA-LNP Efficacy: Synergizing Oxidative Stress Mitigation with Innate Immune Modulation.
Tao LL, Zhai Z, Chen NY, Cheng YX, Liu XH
Pharmaceutics 2026 Feb 19;18(2)
Pharmaceutics 2026 Feb 19;18(2)
S-nitrosation in endothelium: different outcomes of NRF2 and GSNOR loss.
Kopacz A, Kloska D, Kraszewska I, Targosz-Korecka M, Kubisiak A, Jankowska U, Skupien-Rabian B, Grochot-Przeczek A, Jozkowicz A
Free radical biology & medicine 2026 Feb 16;244:323-335
Free radical biology & medicine 2026 Feb 16;244:323-335
Fungal-Bacterial Crosstalk Modulates Glucocorticoid-Primed TLR2 Signaling in the Human Skin.
Cho O, Watanabe K, Sugita T
Microorganisms 2026 Feb 12;14(2)
Microorganisms 2026 Feb 12;14(2)
Gingerenone A ameliorates airway inflammation and remodeling in asthma by modulating the TLR4/MyD88/NF-κB pathway.
Zhu Y, Chen L, Lin J, Chen M, Wu W, Chen Y, Xuan L
Journal of ethnopharmacology 2026 Feb 10;356:120656
Journal of ethnopharmacology 2026 Feb 10;356:120656
The circadian clock component PER2 deficiency aggravates airway epithelial remodeling through Wnt/β-catenin signaling pathway.
Zhang S, Lin J
Respiratory research 2026 Feb 10;27(1)
Respiratory research 2026 Feb 10;27(1)
Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A.
Hu H, Zhan X, Xiong Y, Yuan R, Du Y, Dong Q, Li S, Guo B, Li Z, Feng J, Xiong S, Xiong J, Li D, Fu B, Xu S, Guo J
Oncogene 2026 Apr;45(15):1324-1337
Oncogene 2026 Apr;45(15):1324-1337
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence.
Chuang YF, Wu CR, Chang WH, Su YJ, Hsu HT, Lin FL, Lo YC
The Kaohsiung journal of medical sciences 2026 Apr;42(4):e70117
The Kaohsiung journal of medical sciences 2026 Apr;42(4):e70117
HIF-1α/Netrin-4 Axis Mediates RIPC-Induced Angiogenesis and Neurogenesis After Ischemic Stroke.
Feng Z, Liu Z, Tang S, Pan M, Zhu K, Liu Y, Wang C, Yao R, Wei X, Liu H
Journal of cellular and molecular medicine 2026 Apr;30(7):e71121
Journal of cellular and molecular medicine 2026 Apr;30(7):e71121
Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor.
Ma H, Cao T, Zhang F, Sun D, Chen L, Lin Y, Lai S, Jiang B, Zhou Y, You J, Liu X, Wang Y, Lin F, Liu Y, Wang J, He W, Li Q
Gut 2026 Apr 7;75(5):1016-1029
Gut 2026 Apr 7;75(5):1016-1029
Emerging Alternaria Toxins Drive LX-2 Cells Transdifferentiation into Myofibroblasts for Liver Fibrosis and CotA Detoxification.
Lin H, Jia B, Chang B, Sun F, Tan Y, Tian Y, Fan Y, Liang J, Wu A
Journal of agricultural and food chemistry 2026 Apr 29;74(16):13162-13178
Journal of agricultural and food chemistry 2026 Apr 29;74(16):13162-13178
Esculetin inhibits PRV replication by suppressing activation of the PI3K-AKT/NF-κB pathway.
Zhang Y, Li R, Wan Z, Niu W, Chen Y, Yang G, Xu J, Zhu Y
Veterinary microbiology 2026 Apr 28;318:111038
Veterinary microbiology 2026 Apr 28;318:111038
Peritoneal dialysis-induced senescence contributes to treatment failure in long-term PD.
Oberacker T, Kraft L, Pieper JM, Leibold T, Salega A, Schier R, Dong M, Balasubramanian A, Wülfrath HS, V Samson-Himmelstjerna FA, Thomsen SY, Schrumpf T, Kielstein JT, Eden G, Kolbrink B, Schulte K, Schmitt R, Latus J, Schanz M, Schricker S
Scientific reports 2026 Apr 27;16(1)
Scientific reports 2026 Apr 27;16(1)
Disruption of spike protein N-glycosylation induces its endoplasmic reticulum retention and attenuates SARS-CoV-2 infectivity.
Kong W, Zhang J, Song Y, Song J, Xu Y, Xu X, Ma H, Chen L, Zeng C
Journal of virology 2026 Apr 21;100(4):e0027026
Journal of virology 2026 Apr 21;100(4):e0027026
Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation.
Gañez-Zapater A, Kourtis S, Elbæk CR, Espinar L, Toro-Márquez C, Coll-Manzano A, Smiriglia A, García-López L, Wiegand L, Guirola M, Fontaine F, Morandi A, Müller AC, Sdelci S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 21;:e01083
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 21;:e01083
FAAH initiates a positive feedback loop to promote lung adenocarcinoma progression through inhibition of ferroptosis.
He X, Tang C, Jiang T, Yang C, Zhang X, Ju Z, Zhao J, Wei R, Wang T, Xiong Y, Jia L, Zhang X
Cell death and differentiation 2026 Apr 17;
Cell death and differentiation 2026 Apr 17;
ITLN1 suppresses colorectal cancer progression by inhibiting Wnt/β-catenin-mediated EMT and reprogramming macrophage polarization.
Qin Z, Zhang X, Cheng X
International immunopharmacology 2026 Apr 15;175:116396
International immunopharmacology 2026 Apr 15;175:116396
Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.
Su Y, Liu C, Lu X, Chuang HY, Li G, Shao S, Kong Y, Lee JW, Ng RH, Wong S, Robert L, Warden C, Liu V, Chen J, Wang Z, Qin G, Tang Y, Cheng H, Ng AHC, Chen D, Peng S, Xue M, Johnson D, Xu Y, Wang J, Wu X, Shmulevich I, Shi Q, Levine R, Ribas A, Baltimore D, Guo J, Heath JR, Wei W
Nature communications 2026 Apr 15;17(1)
Nature communications 2026 Apr 15;17(1)
Regulation of PSAT1 and PHGDH by m6A in endocrine-resistant breast cancer cells.
Piell KM, Vallarta A, Wilt AE, Avila-Valdes BL, Sumlut MH, Goli N, Petri BJ, He L, Zhang X, Clem BF, Klinge CM
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 15;:168266
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 15;:168266
Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens nuclear lamina and disrupts 14-3-3 proteins.
Duan Y, Sepehrimanesh M, Hosain MA, Cui H, Stagray J, Shen X, Xiao Y, Li Y, Zhang CL, Ding B
Cell death discovery 2026 Apr 15;
Cell death discovery 2026 Apr 15;
Chronic Psychological Stress Activates TRP/TAM/CXCL1 Signaling to Promote Breast Cancer Adipocyte Lipolysis via KEAP1 m(6)A Demethylation.
Zhan D, She Y, Zhang X, Zhang J, Wang S, Hong S, Zheng Y, Wang N, Wang Z
Research (Washington, D.C.) 2025;8:0980
Research (Washington, D.C.) 2025;8:0980
GPX4 predicts poor prognosis and regulates tumor proliferation and senescence in colorectal adenocarcinoma.
Zhang YU, Wang Q, Han Y, Piao J, Jin X
Oncology research 2025;33(8):1933-1945
Oncology research 2025;33(8):1933-1945
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation.
Huo S, Wang M, Du M, Ren B, Yang T, Peng L, Jiang Y, Peng D, Men L, Shi W, Guo J, Zhang C, Lv J, Li S, Lin L
International journal of biological sciences 2025;21(7):3061-3080
International journal of biological sciences 2025;21(7):3061-3080
WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.
Xu Q, Zhang J, Zou Y, Chen L, Sun F, Luo X, Wang T, Li Y, Zhang S, Xiong F, Yu Q, Yang P, Gong Q, Liu SW, Wang CY
International journal of biological sciences 2025;21(12):5428-5443
International journal of biological sciences 2025;21(12):5428-5443
Inhibiting CXCR6 promotes senescence of activated hepatic stellate cells with limited proinflammatory SASP to attenuate hepatic fibrosis.
Sheng L, Wu Y, Shen F, Xu C
Open life sciences 2025;20(1):20251151
Open life sciences 2025;20(1):20251151
Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway.
Shi Y, Tang Y, Sun Z, Sui P, Shao Y, Wang Z, Zhang J, Gao M
Drug design, development and therapy 2025;19:51-64
Drug design, development and therapy 2025;19:51-64
ADAMTS7 Enhances Gastric Cancer Growth and Metastasis by Triggering the NF-κB Signaling Pathway.
Chen S, He J, Gao H, Gao X, Dai L, Chen J, Sha Z
Journal of Cancer 2025;16(3):1008-1019
Journal of Cancer 2025;16(3):1008-1019
GDF15 is associated with thyroid cancer progression and may modulate thyroid cancer cell senescence in a p53-dependent manner.
Ma J, Liu Z, Hua R, Ding C, Yang Z, Liang W, Lv B
Frontiers in endocrinology 2025;16:1675245
Frontiers in endocrinology 2025;16:1675245
Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury.
Hou M, Wang Y, Chen S, Tan Z, Liu J, Li X, Han X, Yang Z, Leng Y
Frontiers in immunology 2025;16:1623080
Frontiers in immunology 2025;16:1623080
Isoliensinine exerts antitumor effects in lung adenocarcinoma by inhibiting APEX1-driven ROS production.
Chen C, Shu C, Shen D, Yan Z, Liu Z, Huang JA
Frontiers in pharmacology 2025;16:1555802
Frontiers in pharmacology 2025;16:1555802
Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway.
Dao JJ, Zhang W, Liu C, Li Q, Qiao CM, Cui C, Shen YQ, Chen SX, Zhao WJ
Frontiers in pharmacology 2025;16:1528604
Frontiers in pharmacology 2025;16:1528604
The TMBIM1-YBX1 axis orchestrates MDSC recruitment and immunosuppressive microenvironment in pancreatic cancer.
Tong X, Xiao M, Yang J, Xu J, Wang W, Yu X, Shi S
Theranostics 2025;15(7):2794-2813
Theranostics 2025;15(7):2794-2813
PPP1R12B inhibits cell proliferation by inducing G0/G1 phase arrest via PAK2/β-catenin axis in hepatocellular carcinoma.
Zhang Y, Liu S, Bai M, Zhao Z, Wang S, Bao M, Bao J, Shen S, Lu S, Xiong Y, Gu G, Wang H, Chen L
Frontiers in cell and developmental biology 2025;13:1621705
Frontiers in cell and developmental biology 2025;13:1621705
Garlic oil-loaded nanodisks for the amelioration of acute lung injury via modulation of the NF-κB and Keap1-Nrf2 axis.
Hou R, Jiang B, Wang K, Yang X, Zhang W
Frontiers in molecular biosciences 2025;12:1686436
Frontiers in molecular biosciences 2025;12:1686436
Suramin blocked hCAP18/LL-37-induced macrophage recruitment and M2 polarization to enhance the therapeutic efficacy of 1,25(OH)(2)D(3) against hepatocellular carcinoma in vitro and in vivo mouse model.
Zhang H, Xie W, Duan W, Yuan X, Yang Y, Chen Q, Zhu Y, Chen Y
Frontiers in nutrition 2025;12:1556533
Frontiers in nutrition 2025;12:1556533
A novel glucomannan from Bletilla striata ameliorates colitis: Restores intestinal barrier, alleviates inflammation, and modulates the gut flora.
Sun X, Zhang T, Zhao Y, Yang H, Li Y, Sun X, Bian X
International journal of biological macromolecules 2025 Sep;321(Pt 3):146421
International journal of biological macromolecules 2025 Sep;321(Pt 3):146421
Congenital Hypothyroidism Dysregulates TRPC6 to Mediate Abnormal Dendritic Spine Growth of Hippocampal Neurons.
Li T, Shen F, Li L, Chen P, Zhu Z, Zheng Y, Li H, Suo G, Wang Y, Shi J, Wu Y
CNS neuroscience & therapeutics 2025 Sep;31(9):e70618
CNS neuroscience & therapeutics 2025 Sep;31(9):e70618
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription.
Cai Y, Zheng J, Zhao L, Wang X, Zhang L, Wang J, Zhang Y, Shi R, Han J, Han W, Chen W
Nature immunology 2025 Sep;26(9):1581-1595
Nature immunology 2025 Sep;26(9):1581-1595
Age-Dependent Histone Deacetylase 3 Regulation by βA3/A1-Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age-Related Macular Degeneration.
Chatterjee S, Ghosh S, Sin Z, Babu VS, Preval LV, Davis E, Tran N, Bammidi S, Gautam P, Hose S, Sergeev Y, Flores-Bellver M, Ritter K, Jessen HJ, Al Diri I, Sinha D, Guha P
Aging cell 2025 Sep;24(9):e70163
Aging cell 2025 Sep;24(9):e70163
Bioactive ROS-responsive nanotherapeutics attenuate intermittent hypoxia-induced cognitive impairment via NRF2/KEAP1/HO-1 signaling.
Huang Y, Xie H, Liu L, Zhao H, Li B, Zhang F
Neurochemistry international 2025 Sep;188:105997
Neurochemistry international 2025 Sep;188:105997
Downregulation of ANXA2 suppresses trophoblast cell invasion and migration through β-catenin pathway in preeclampsia.
Mei Z, Gong M, Lai J, Liu P, Wang Y, Du P, He F
Placenta 2025 Sep;169:60-71
Placenta 2025 Sep;169:60-71
Artemisitene Ameliorates Diabetic Wounds by Inhibiting Ferroptosis Through Activation of the Nrf2/GPX4 Pathway.
Honghao X, Yitian B, Yuan Z, Zhengyang L, Feiya Z, Leyi C, Weiyang G, Anyuan W, Hongqiang W
Food science & nutrition 2025 Sep;13(9):e70952
Food science & nutrition 2025 Sep;13(9):e70952
Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis-Mediated DNA Repair in Osteosarcoma.
Liang Y, Li Z, Tang L, Pan Z, Fei X, Tan C, He A, Yang Q, Cheng D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e02926
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e02926
A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage.
Moss T, Wooldredge A, Bhakta K, Cronin M, Gestwicki JE, Mukherjee S
bioRxiv : the preprint server for biology 2025 Sep 6;
bioRxiv : the preprint server for biology 2025 Sep 6;
Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.
Guo M, Yuan Z, Jin X, Li X, Deng Y, Zhou S, Niu R, Bae J, Park JB, Shi B, Yin J
Nature communications 2025 Sep 30;16(1):8642
Nature communications 2025 Sep 30;16(1):8642
CHD4 drives gastric cancer metastasis via MYH9/GSK3β/β-catenin axis and WNT/EMT pathway activation.
Shi Y, Zhao Z, Zhou S, Zhou Z, Huang Z, Zhou Z, Zhang C
Cancer letters 2025 Sep 28;628:217813
Cancer letters 2025 Sep 28;628:217813
TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis.
Zhang X, Yao H, Hou Y, Zhou K, Liang Y, Hou L, Zhang X, Wang W, Du L, Yao M, Wang J, Meng X
Cell death discovery 2025 Sep 25;11(1):422
Cell death discovery 2025 Sep 25;11(1):422
Sheng Mai San Mitigates Heat Stress-Induced Myocardial Injury by Coordinated Regulation of the Keap1-Nrf2-HO-1 and Stub1-HSF1 Signaling Pathways.
Dong J, Ma Q, Yang R, Zhang X, Hua Y, Ji P, Yao W, Yuan Z, Wei Y
Antioxidants (Basel, Switzerland) 2025 Sep 22;14(9)
Antioxidants (Basel, Switzerland) 2025 Sep 22;14(9)
Protective Effect of Hepcidin on Sepsis-Associated Acute Kidney Injury via Activating the Nrf2/GPX4 Signaling Pathway.
Guo LB, Wu SS, Xu F, Chen XX, Fan H
Current issues in molecular biology 2025 Sep 18;47(9)
Current issues in molecular biology 2025 Sep 18;47(9)
TGF-β(1) induces super-enhancers at the loci of the EMT-related genes in human keratinocyte HaCaT cells.
Takeda K, Nagaoka Y, Tamaoki S, Hatta M
Gene 2025 Sep 15;965:149668
Gene 2025 Sep 15;965:149668
TRAF2 mediates Wnt-induced β-catenin nuclear translocation by associating with the nuclear pore complex.
Yang M, Xuan Y, Hao P, Li Y, Zhang C, Zhao W, Zhang Y, Zhang X, Zhou X, Zhu H, Li H, Yang Y, Wang J, Yan R, Qu Y, Ke X
Life sciences 2025 Sep 15;377:123722
Life sciences 2025 Sep 15;377:123722
African swine fever virus pNP419L inhibits type I interferon signaling by blocking ISGF3-mediated transcriptional activation.
Chen Q, Liu L, Wu W, Li L, Yu Z, Liu Q, Wang D, Tan C, Chen H, Wang X
International journal of biological macromolecules 2025 Sep 15;328(Pt 2):147704
International journal of biological macromolecules 2025 Sep 15;328(Pt 2):147704
Data-independent acquisition-based quantitative proteomic analysis of the effects of environmental enrichment on the dorsal roots of mice with neuropathic pain induced by chronic sciatic nerve constriction injury.
Pan J, Lin H, Feng J, Yang Y, Yang K, Yu Y, Yu Y
Neuropharmacology 2025 Sep 1;275:110481
Neuropharmacology 2025 Sep 1;275:110481
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.
Xu H, He TQ, Chen SY, Shi RR, Xu J, Xing YR, Shi D, Liu YQ, He BS, Gu JH
Redox biology 2025 Oct;86:103803
Redox biology 2025 Oct;86:103803
Therapeutic targeting of Nrf2/HO-1/NF-κB signaling axis with casticin mitigates intervertebral disc degeneration: in vitro and in vivo investigations.
Wu L, Wang Z, Wu Z, Wu Y
In vitro cellular & developmental biology. Animal 2025 Oct;61(9):1120-1136
In vitro cellular & developmental biology. Animal 2025 Oct;61(9):1120-1136
Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization.
Liu D, Zhang Y, Li D, Jiang B, Zhao X, Li Y, Lin Z, Zhao Y, Hu Z, Deng S, Li Z, Lu H, Chan KKL, Yeung WSB, Kaldis P, Yao C, Wang H, Chow LT, Liu K
The EMBO journal 2025 Oct;44(19):5509-5536
The EMBO journal 2025 Oct;44(19):5509-5536
BRPF1 inhibitor GSK6853 inhibits NSCLC cell proliferation via the JAK2/STAT3/CCNA2 axis to induce cell cycle arrest.
Yang J, Ji W, Liao L, Jiang B, Gao C, Huang Y, Mao Z, Ji L, Liu F, Zeng J
Investigational new drugs 2025 Oct;43(5):1139-1147
Investigational new drugs 2025 Oct;43(5):1139-1147
OGT-Mediated O-GlcNAcylation of ATF2 Protects Against Sepsis-Associated Encephalopathy by Inhibiting Microglial Pyroptosis.
Yao H, Liang C, Wang X, Duan C, Song X, Shang Y, Zhang M, Peng Y, Zhang D
Neuroscience bulletin 2025 Oct;41(10):1761-1778
Neuroscience bulletin 2025 Oct;41(10):1761-1778
Guanosine enhances thermogenesis and impairs KEAP1-mediated NRF2 degradation to resist ferroptosis in brown adipose tissue.
Tang Y, Zhao M, Wang N, Nie H, Song J, Zhou Z, Tang W, Zhang J, Li C, Fang L
Free radical biology & medicine 2025 Oct;238:360-369
Free radical biology & medicine 2025 Oct;238:360-369
Galectin-3 gene deletion alters lipid profile in healthy and cardiomyopathy mouse hearts.
Du XJ, Huynh K, Ziemann M, She G, Wu W, Duong T, Hai XX, Yang YY, Zhao WB, Lu Q, Zhang Y, Deng XL, Meikle PJ
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159676
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159676
Acetyl-CoA Short-Chain Synthetase-2 Regulates Myocardial Ischemia/Reperfusion Injury by Targeting Histone Acetylation.
Chen X, Xu Q, Ding W, Wang Y, Wang P, Zhao C, Ao X, Wang J
Journal of cardiovascular translational research 2025 Oct;18(5):1100-1112
Journal of cardiovascular translational research 2025 Oct;18(5):1100-1112
5-HT regulates resistance to aumolertinib by attenuating ferroptosis in lung adenocarcinoma.
Feng Y, He Y, Zuo R, Gong W, Gao Y, Wang Y, Wang Y, Chen W, Chen L, Luo Y, Yuan D, Chen P, Guo H
EMBO molecular medicine 2025 Oct;17(10):2586-2611
EMBO molecular medicine 2025 Oct;17(10):2586-2611
The AKT-USP15 axis modulates autophagy in MPP(+)-induced Parkinson's disease model of SN4741 cells.
Wu X, Wen Y, Yuan Y, Bai T, Yang N, Xu L, Ma Y, Su P, Luo W, Li W
Cellular signalling 2025 Oct;134:111879
Cellular signalling 2025 Oct;134:111879
Forsythiaside A Suppresses Ferroptosis and Mitigates Type 2 Diabetes Osteoporosis Through the NRF2/GPX4 Axis.
Huang YX, Bu YT, Zhang YK, Wang YK, Guo YF, Jin C, Feng SX, Kong LF, Chen WK, Yang L
Food science & nutrition 2025 Oct;13(10):e70991
Food science & nutrition 2025 Oct;13(10):e70991
Eimeria tenella aspartyl protease is identified as a potential TLR15 ligand and activates macrophages and dendritic cells in chickens.
Chen C, Men Z, Pu X, Lu M, Xu L, Yan R, Li X, Song X
Poultry science 2025 Oct;104(10):105525
Poultry science 2025 Oct;104(10):105525
Lycium barbarum Polysaccharides Suppress Radiation-Induced Microglial Inflammation by Inhibiting the IKKβ/IκBα/NF-κB Pathway.
Zhang X, Liu Q, Liu L, Qian F, Ren BX, Tang FR
Dose-response : a publication of International Hormesis Society 2025 Oct-Dec;23(4):15593258251382964
Dose-response : a publication of International Hormesis Society 2025 Oct-Dec;23(4):15593258251382964
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer.
Xiao Y, Xu Y, Wang H, Yang F, Ding XH, Fu T, Chen L, Jin X, Zhao YX, Wang Y, Chen F, Shao ZM, Jiang YZ
Cell metabolism 2025 Oct 7;37(10):2030-2047.e7
Cell metabolism 2025 Oct 7;37(10):2030-2047.e7
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice.
Zhu XX, Meng XY, Zhang AY, Zhao CY, Wei YT, Wen YY, Su JB, Fu X, Chen G, Xu AJ, Wang MY, Ji LM, Bao N, Bao ZY, Li N, Lu QB, Sun HJ
Nature communications 2025 Oct 24;16(1):9436
Nature communications 2025 Oct 24;16(1):9436
Nuclei sense complex tissue shape and direct intestinal stem cell fate.
Bera K, McNally DL, Kirkpatrick BE, Petrich NR, Yavitt FM, Coulombe M, Quintero M, Skillin NP, Khang A, McGrath PS, Samuelson LC, Lele TP, Dempsey PJ, Anseth KS
bioRxiv : the preprint server for biology 2025 Oct 24;
bioRxiv : the preprint server for biology 2025 Oct 24;
Pseudorabies virus DNA polymerase processivity factor pUL42 inhibits type I IFN production by negatively regulating cGAS-STING signaling pathway.
Ye G, Gao J, Cao H, Liu X, Liu H, Wang S, Liu Y, Han L, Zhou Q, Tang Y, Tian J, Huang L, Huang L, Zhang Z, Weng C
Journal of virology 2025 Oct 23;99(10):e0121825
Journal of virology 2025 Oct 23;99(10):e0121825
ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8-mediated SUMOylation of nonstructural protein 5.
Du J, Li C, Zhang J, Luo J, Zhang H, Xie S, Chen H, Li X, Qian P
Journal of virology 2025 Oct 23;99(10):e0086825
Journal of virology 2025 Oct 23;99(10):e0086825
Gamma-aminobutyric acid attenuates cortisol-induced damage in human colorectal adenocarcinoma cells via Nrf2 signaling.
Liu Y, Wu Y
Die Naturwissenschaften 2025 Oct 20;112(6):82
Die Naturwissenschaften 2025 Oct 20;112(6):82
Senescent fibroblasts modulate the radiation response of neighboring epithelial cells.
Buchholzki M, Stasch LM, Budeus B, Ketheeswaranathan V, Sevindik ZF, Jendrossek V, Klein D
Cell death discovery 2025 Oct 20;11(1):468
Cell death discovery 2025 Oct 20;11(1):468
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming.
Wang J, Yang X, Su X, Yi W, Sun W, Wei J, Ning YQ, Yan J
Journal of translational medicine 2025 Oct 17;23(1):1127
Journal of translational medicine 2025 Oct 17;23(1):1127
Epigenetic regulation by WTAPP1 promotes trophoblast dysfunction in gestational diabetes via CNR1/NF-κB activation.
Yang N, Li Y, Zhang J, Gao X, Zhang P, Li W
European journal of medical research 2025 Oct 15;30(1):975
European journal of medical research 2025 Oct 15;30(1):975
Pediatric doxorubicin exposure induces persistent pathological changes in mice.
Chen J, Belew MD, Wei J, Chow EJ, Cheng Z
Toxicology and applied pharmacology 2025 Oct 14;505:117600
Toxicology and applied pharmacology 2025 Oct 14;505:117600
Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression.
Zhao K, Zhang F, Qin Q, Zhang D, Yang F, Huang Y, Deng R, Jing H, Xiao W, Miao H, Shi R
Molecular biomedicine 2025 Oct 11;6(1):79
Molecular biomedicine 2025 Oct 11;6(1):79
Blockade of TGF-β1/Smad3 signaling pathway by Bovine Milk-derived extracellular vesicles ameliorates skin fibrosis in systemic sclerosis mice.
Chi J, Li X, Zhu Z, Yang L, Luo C, Chen X, Yuan L, Lu Y, Wang W, Liang C
Biochemical and biophysical research communications 2025 Oct 10;784:152579
Biochemical and biophysical research communications 2025 Oct 10;784:152579
Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy.
Zhang C, Chen Y, Zhu S, Wang Z, Lin H, Lu J, Zhang H, Weng Y, Huang X, Li G, Wu Y, Li Z, Hu J, Xie C, Lai J, Tian Y, Liao C, Chen S
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Nov;83:101292
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Nov;83:101292
Molecular mechanism of the crosstalk between glucocorticoid receptor (GR) and hypoxia-inducible factor 3α (HIF-3α) pathways.
Zhang M, Guo Y, Diao X, Guo M, Teng H, Sun X, Zhuang J, Song C, Xie X, Wu D
Marine life science & technology 2025 Nov;7(4):779-791
Marine life science & technology 2025 Nov;7(4):779-791
Intranuclear paraspeckle-circular RNA TACC3 assembly forms RNA-DNA hybrids to facilitate MASH-related hepatocellular carcinoma growth in an m(6)A-dependent manner.
Fu J, Wei Y, Yang Y, Yang X, Ouyang T, Wang X, Chen S, Liu Z, Su Y, Fu J, Yu M, Qian H, Song H, Xu S, Zhao R, Jiang X, Huo Y, Zhang M, Yang P, Yang Z, Wang K, Li L, Wang H
Cancer communications (London, England) 2025 Nov;45(11):1583-1610
Cancer communications (London, England) 2025 Nov;45(11):1583-1610
STN1 Shields CTC1 From TRIM32-Mediated Ubiquitination to Prevent Cellular Aging.
Lan Y, Liang X, Kuang G, Ma T, Zhang F, Huang Z, Wang H, Luo Z, Feng X
Aging cell 2025 Nov;24(11):e70214
Aging cell 2025 Nov;24(11):e70214
FBXW7 is a multifaceted regulator of the innate immune response to DNA viruses.
Sun XD, Wang JL, Zhang XY, Ruan ZL, Liang W, Guo Y, Guan WT, Yang Q, Li L, Shu HB, Hu MM
Cellular & molecular immunology 2025 Nov;22(11):1427-1443
Cellular & molecular immunology 2025 Nov;22(11):1427-1443
Amlodipine synergizes with temozolomide against glioma stem cells by modulating MGMT expression through downregulation of the AKT/GSK3β/β-catenin axis.
Zhang X, Li Z, Wen P, Yin N, Zhang Z, Zhong T, Xia F, Pan J, Liu L, Dong J
Cellular signalling 2025 Nov;135:112012
Cellular signalling 2025 Nov;135:112012
Discovery of a novel Genipin derivative targeting YB-1 to enhance the P-glycoprotein-mediated paclitaxel sensitivity of paclitaxel-resistant non-small cell lung cancer.
Deng L, Zhang G, He M, Wang Y, Li J, Xu X, Hao X, Fan Y, Mu S
European journal of medicinal chemistry 2025 Nov 5;297:117910
European journal of medicinal chemistry 2025 Nov 5;297:117910
A serum-free adipose-conditioned medium delays stem cell senescence and maintains tissue homeostasis via IL-6/STAT3 axis suppression.
Li J, Song L, Song D, Su Z, Bi J, Huo R
Stem cell research & therapy 2025 Nov 28;16(1):668
Stem cell research & therapy 2025 Nov 28;16(1):668
Botulinum Neurotoxin Type A Combined with Platelet-Rich Plasma Promotes Hair Follicle Growth and Regeneration via STMN1 Modulation and Wnt/β-Catenin Pathway Activation.
Li J, Jia Z, Zhou Y, Gao L, Ma Y
Journal of microbiology and biotechnology 2025 Nov 26;35:e2507033
Journal of microbiology and biotechnology 2025 Nov 26;35:e2507033
Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging.
Yang D, Le J, Xiao S, Cui Y, Zhu W, Otsuki K, Li W, Xu J, Feng F, Zhang J
Antioxidants (Basel, Switzerland) 2025 Nov 25;14(12)
Antioxidants (Basel, Switzerland) 2025 Nov 25;14(12)
The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression.
Yang J, Yu Z, Feng Y, Wang S, Li C, Mao Y, Xu W, Chen J
Journal of translational medicine 2025 Nov 22;24(1):1
Journal of translational medicine 2025 Nov 22;24(1):1
Dendrobine alleviates CCl(4)-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways.
Yang Y, Fu X, Tan L, Xian S, Fan N, Gan Q, Nan N, Hu L, Shi J, Wu Q, Zhou S
Chinese medicine 2025 Nov 2;20(1):182
Chinese medicine 2025 Nov 2;20(1):182
Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD.
Liu L, Zhong S, Zhou T, Wu Y, Hu W, Wang X, Ren Y, Wang K, Lin X, Zhang J
Journal of advanced research 2025 Nov 19;
Journal of advanced research 2025 Nov 19;
Tau impedes glioma progression by enhancing fatty acid β-oxidation-induced cellular senescence.
Han WH, Zhao WJ, He JW, Zhao WP, Lu HW, Lu ZW, Qiu XS, Chang C, Zhang YY, Xie YY, Geng YY, Zhang BC, Wang ZX
Zoological research 2025 Nov 18;46(6):1304-1316
Zoological research 2025 Nov 18;46(6):1304-1316
Up-regulation of Ifi27l2a expression in bone marrow monocytes contributes to glucocorticoid-induced bone loss.
Wang Z, Huang C, Liu S, Xiao P, Lu Z, Xu Y, Tian Y
Communications biology 2025 Nov 17;8(1):1590
Communications biology 2025 Nov 17;8(1):1590
CDC5L facilitates cardiomyocyte proliferation and ameliorates myocardial ischemia-reperfusion injury via modulation of the FGF10-YAP axis.
Wei T, Wan T, Sun Y, Liang Y, Lin Z, Shen S, Zhang Q, Chen M, Li Y
Acta biochimica et biophysica Sinica 2025 Nov 14;57(12):2110-23
Acta biochimica et biophysica Sinica 2025 Nov 14;57(12):2110-23
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
Li N, Zhang R, Zhao XX, Zhou L, Li YL, Cui ZG, Zheng HC
International immunopharmacology 2025 Nov 14;165:115445
International immunopharmacology 2025 Nov 14;165:115445
Leucokinin VIII acetate mitigates asthma severity by targeting ADCK5-induced cellular senescence.
Feng L, Zhong Y, Li L, Zhang M, Zhu M, Wang J, Huang M, Ji N, Ma Y
International immunopharmacology 2025 Nov 14;165:115426
International immunopharmacology 2025 Nov 14;165:115426
DNAJC9 Binds to and Enhances the Transcription of Hepatitis B Virus cccDNA by Recruiting Histone H3.3.
Mao T, Du X, Li Y, Zhou Z, Li D, Zheng L, Zhang T, Li G, Yang D, Chen X, Lu F
Journal of medical virology 2025 May;97(5):e70390
Journal of medical virology 2025 May;97(5):e70390
Ursonic Acid Ameliorates H(2)O(2)-Induced Oxidative Damage in PC12 Cells and Prolonged the Lifespan in C. elegans by Activating MAPKs/Nrf2/HO-1 Signaling Pathway.
Wang J, Yang J, Lu J, Lu J, Ling B, Song Y, Chen G
Molecular neurobiology 2025 May;62(5):6598-6611
Molecular neurobiology 2025 May;62(5):6598-6611
Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function.
Jiang C, Gong Y, Wu X, Chen J, Chen Y, Chen J, Tang F, Fang Z, Bao Y, Ye J, Wang Z, Hong Z
Journal of orthopaedic translation 2025 May;52:220-232
Journal of orthopaedic translation 2025 May;52:220-232
Methyltransferase-like enzyme 14 exacerbates retinal ganglion cell damage and diabetic retinopathy through N6-methyladenosine-dependent upregulation of pleckstrin homology domain and leucine rich repeat protein phosphatase 2.
Chen L, Wei T, Liu X, Cui L, Hu C, Quan Y
Toxicology and applied pharmacology 2025 May;498:117304
Toxicology and applied pharmacology 2025 May;498:117304
CREB1-BCL2 drives mitochondrial resilience in RAS GAP-dependent breast cancer chemoresistance.
Man KF, Darweesh O, Hong J, Thompson A, O'Connor C, Bonaldo C, Melkonyan MN, Sun M, Patel R, Ellisen LW, Robinson T, Song D, Koh SB
Oncogene 2025 May;44(16):1093-1105
Oncogene 2025 May;44(16):1093-1105
MTA1-DT promotes endometrial cancer growth by modulating G2/M-related gene transcription via PURα.
Liu Y, Li X, Wang F, Cai J, Li Z, Huang Y, Duan X, Liu X, He Y, Xu G, Lu Q
International journal of biological macromolecules 2025 May;309(Pt 4):142943
International journal of biological macromolecules 2025 May;309(Pt 4):142943
Tracking of single virus: Dual fluorescent labeling of pseudorabies virus for observing entry and replication in the N2a cells.
Li M, Pan L, Ma C, Wu H, Xiang G, Li LF, Wang T, Luo R, Li Y, Liu D, Zhai H, Assad M, Song X, Wang Y, Gallardo F, Qiu HJ, Sun Y
Veterinary microbiology 2025 May;304:110503
Veterinary microbiology 2025 May;304:110503
Lingguizhugan Decoction improves chronic heart failure by synergistically modulating ?1-AR/Gs/GRKs/?-arrestin signaling bias.
Guo S, Xia L, Yang S, Liang Y, Shan X, Zhao P, Guo W, Zhang C, Xu M, Sun N, Lu R, Chen H
Chinese journal of natural medicines 2025 May;23(5):560-571
Chinese journal of natural medicines 2025 May;23(5):560-571
IRF4 contributes to chemoresistance in IGH::BCL2-positive diffuse large B-cell lymphomas by mediating BCL2-induced SOX9 expression.
Zhang Y, Xu Z, Sun R, Gao Y, Agida I, Aximujiang K, Yuan L, Ma J
Clinical and translational medicine 2025 May;15(5):e70336
Clinical and translational medicine 2025 May;15(5):e70336
Identification and Functional Analysis of Novel Mutations in AXIN2 and LRP6 Linked With Non-Syndromic Tooth Agenesis.
Luo W, Yue H, Song G, Cheng J, He M
Molecular genetics & genomic medicine 2025 May;13(5):e70101
Molecular genetics & genomic medicine 2025 May;13(5):e70101
TRAF3IP3 Induces ER Stress-Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation.
Zhao G, Qi J, Li F, Ma H, Wang R, Yu X, Wang Y, Qin S, Wu J, Huang C, Ren H, Zhang B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2411020
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2411020
Inactivation of TACC2 epigenetically represses CDKN1A and confers sensitivity to CDK inhibitors.
Lin ZR, Xia TL, Wang MY, Zhang LJ, Liu YM, Yuan BY, Zhou AJ, Yuan L, Zheng J, Bei JX, Lin DX, Zeng MS, Zhong Q
Med (New York, N.Y.) 2025 May 9;6(5):100568
Med (New York, N.Y.) 2025 May 9;6(5):100568
Sciellin inhibits senescence and promotes pancreatic cancer progress by activating the notch signaling pathway.
Wu C, Luo D, Shi B, Chen S, Sun C, He Z, Yu C
Scientific reports 2025 May 8;15(1):16133
Scientific reports 2025 May 8;15(1):16133
A cardiac fibroblast-enriched micropeptide regulates inflammation in ischemia/reperfusion injury.
Yan Y, Zhang T, He X, Du T, Dai G, Xu X, Chen Z, Wu J, Zhou H, Peng Y, Li Y, Liu C, Liao X, Dong Y, Ou JS, Huang ZP
JCI insight 2025 May 8;10(9)
JCI insight 2025 May 8;10(9)
Alpha-lipoic acid alleviated intermittent hypoxia-induced myocardial injury in mice by promoting autophagy through Nrf2 signaling pathway.
Wang X, Song SM, Lu WQ, Zhao Y, Lv RJ, He Y, Dong N, Yu Q, Yue HM
European journal of pharmacology 2025 May 5;994:177380
European journal of pharmacology 2025 May 5;994:177380
Rab GTPases are evolutionarily conserved signals mediating selective autophagy.
Zhao P, Tian R, Song D, Zhu Q, Ding X, Zhang J, Cao B, Zhang M, Xu Y, Fang J, Tan J, Yi C, Xia H, Liu W, Zou W, Sun Q
The Journal of cell biology 2025 May 5;224(5)
The Journal of cell biology 2025 May 5;224(5)
KRT6A Restricts Influenza A Virus Replication by Inhibiting the Nuclear Import and Assembly of Viral Ribonucleoprotein Complex.
Chang Y, Shan Z, Shi W, Li Q, Wang Y, Wang B, Wang G, Chen H, Jiang L, Li C
Viruses 2025 May 4;17(5)
Viruses 2025 May 4;17(5)
Ethanol extract of Moschus attenuates glutamate-induced cytotoxicity in HT22 cells by regulating the Nrf2 and MAPK pathways.
Chu Z, Chen Y, Xie D, Song C, Yang L, Qin T, Zhai Z, Cao Z, Xu Y, Sun T
Journal of ethnopharmacology 2025 May 28;348:119879
Journal of ethnopharmacology 2025 May 28;348:119879
Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism.
Lyu SY, Xiao W, Chen YJ, Liao QL, Cai YY, Yu C, Liu JY, Liu H, Zhang MP, Ren YL, Yu QL, Qi YM, Xiao EH, Luo YH
World journal of gastroenterology 2025 May 28;31(20):105554
World journal of gastroenterology 2025 May 28;31(20):105554
Erucin Alleviates Cardiac Hypertrophy by Improving Mitochondrial Function via Nrf2-Sirt3 Pathway.
Jiang S, Wang C, Dong Y, Chen L, Shi M, Zhang F, Wang Z, Liang M
Phytotherapy research : PTR 2025 May 26;
Phytotherapy research : PTR 2025 May 26;
Pre-ischaemic empagliflozin treatment attenuates blood-brain barrier disruption via β-catenin mediated protection of cerebral endothelial cells.
Liu G, Qiu Y, You N, Yu M, Chen W, Sun T, Qin Z, Han M, Xue Z, Liang X, Mao B, Ling L, Wu Y, Xing W, Liu Q, Wang D
Cardiovascular research 2025 May 23;121(5):788-802
Cardiovascular research 2025 May 23;121(5):788-802
The S273R protein of African swine fever virus antagonizes the canonical NF-κB signaling pathway by IκBα.
Ren H, Shi L-F, Wang Y, Pan X-Y, Li S, Ma Y-H, Fan J-H, Chen X, Yang Z-Y, Fan S, Zhang Y, Han S, He W-R, Wan B, Qiu H-J, Zhang G-P
Journal of virology 2025 May 20;99(5):e0222524
Journal of virology 2025 May 20;99(5):e0222524
H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation.
Fukuda K, Shimura C, Shinkai Y
Epigenetics & chromatin 2025 May 2;18(1):26
Epigenetics & chromatin 2025 May 2;18(1):26
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis.
Sheng X, Jin L, Yao Z, Gu J, Zhu L, Huang A, Peng J, Xu X, Ge X, Zhou W, Sheng J, Xu Z, Bai R
Cell discovery 2025 May 13;11(1):46
Cell discovery 2025 May 13;11(1):46
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition.
He J, Zhu Y, Tian Z, Liu M, Gao A, Fu W, Lu F, Sun Y, Guo Y, Pan R, Ji Y, Chen J, Lu H, Lin J, Liang X, Kim C, Zhou C, Jiao H
Molecular cell 2025 May 1;85(9):1790-1805.e7
Molecular cell 2025 May 1;85(9):1790-1805.e7
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Yang ZH, Wu P, Zhang BX, Yang CR, Huang J, Wu L, Guo SH, Zhou Y, Mao Y, Yin Y, Wu X, Cheng P, Li B, Zhou R, Shen HM, Nie S, Cai ZY, Mo W
Molecular cell 2025 May 1;85(9):1775-1789.e5
Molecular cell 2025 May 1;85(9):1775-1789.e5
Novel Function of NUP153 in HNF4α Transcriptional Upregulation Contributes to Promoting HBV Replication.
Jiang Q, Zhou Z, Du X, Li Y, Guan G, Zhang T, Liu X, Yang D, Wang L, Chen X, Chen H, Lu F
Journal of medical virology 2025 Mar;97(3):e70256
Journal of medical virology 2025 Mar;97(3):e70256
Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice.
Huo L, Zhang H, Tang C, Cui G, Xue T, Guo H, Yao F, Zhang W, Feng W
Molecular neurobiology 2025 Mar;62(3):3568-3582
Molecular neurobiology 2025 Mar;62(3):3568-3582
A subset of human dermal fibroblasts overexpressing Cockayne syndrome group B protein resist UVB radiation-mediated premature senescence.
Fotopoulou A, Angelopoulou MT, Pratsinis H, Mavrogonatou E, Kletsas D
Aging cell 2025 Mar;24(3):e14422
Aging cell 2025 Mar;24(3):e14422
USP13 inhibition exacerbates mitochondrial dysfunction and acute kidney injury by acting on MCL-1.
Wang Q, Cao S, Sun Z, Zhu W, Sun L, Li Y, Luo D, Huang S, Zhang Y, Xia W, Zhang A, Jia Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167599
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167599
Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.
Liao X, Tang M, Li J, Guo R, Zhong C, Chen X, Zhang X, Mo H, Que D, Yu W, Song X, Li H, Cai Y, Yang P
Advanced healthcare materials 2025 Mar;14(7):e2404319
Advanced healthcare materials 2025 Mar;14(7):e2404319
Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2/SIRT3 signaling pathway.
Lu D, Wu S, Wang X, Zhang J, Xu Y, Tao L, Shen X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156389
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156389
Rosa roxburghii Fermentation Broths Attenuate Bleomycin-Induced Pulmonary Fibrosis by Activating the Nrf2/HO-1/NQO1 Signaling Pathway and Modulating Gut Microbiota.
Zhou H, Zheng X, Huang S, Wang X, Zhou T, Zhang S, Ling Y, Wang W, Li X, Li S, Xie Y, Yin W
Food science & nutrition 2025 Mar;13(3):e70105
Food science & nutrition 2025 Mar;13(3):e70105
Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway.
Wang J, He Y, Zhu X, Zhu J, Deng Z, Zhang H, Chen Y, Zhang G, Shi T, Chen W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2409419
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2409419
Inhibiting HMGB1/AGER/NF-κB pathway prevents pro-inflammatory microglia polarization and protect photoreceptors in retinitis pigmentosa.
Hu C, Cui T, Xu Z, Yang K, Wu Y, Cai W, Yu J, Qiu Y
International immunopharmacology 2025 Mar 6;149:114192
International immunopharmacology 2025 Mar 6;149:114192
TEPP-46 inhibits glycolysis to promote M2 polarization of microglia after ischemic stroke.
Xia X, Chen W, Zhou T, Zhou F, Lu C, Yan Z, Zhao Q, Su Q
International immunopharmacology 2025 Mar 6;149:114148
International immunopharmacology 2025 Mar 6;149:114148
Adipose progenitor cell-derived extracellular vesicles suppress macrophage M1 program to alleviate midlife obesity.
Zhou Q, Gao J, Wu G, Wang C, Yang Y, Huang T, Wang Y, Yue T, Gao Z, Xie H, Xiong F, Xiang K, Yong T, Zhang W, Zhang T, Kong W, Chen C, Zhang S, Yu Q, Fan X, Liu S, Liu Y, Wang CY
Nature communications 2025 Mar 20;16(1):2743
Nature communications 2025 Mar 20;16(1):2743
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Ma C, Zhang L, Huang Q, Deng Q, Huang F, Xu J
Food & function 2025 Mar 17;16(6):2589-2597
Food & function 2025 Mar 17;16(6):2589-2597
MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers.
Georgiou K, Sarigol F, Nimpf T, Knapp C, Filipczak D, Foisner R, Naetar N
Nature communications 2025 Mar 17;16(1):2614
Nature communications 2025 Mar 17;16(1):2614
Small extracellular vesicles from young adipose-derived stem cells ameliorate age-related changes in the heart of old mice.
Sanz-Ros J, Huete-Acevedo J, Mas-Bargues C, Romero-García N, Dromant M, van Weeghel M, Janssens GE, Borrás C
Stem cell research & therapy 2025 Mar 13;16(1):138
Stem cell research & therapy 2025 Mar 13;16(1):138
A novel KEAP1 inhibitor, tiliroside, activates NRF2 to protect against acetaminophen-induced oxidative stress and acute liver injury.
Cai F, Zhou K, Wang P, Zhang W, Liu L, Yang Y
Hepatology communications 2025 Mar 1;9(3)
Hepatology communications 2025 Mar 1;9(3)
Arsenic exposure induces neural cells senescence and abnormal lipid droplet accumulation leading to social memory impairment in mice.
Zhang B, Chen J, Wang J, Pan X
Environmental pollution (Barking, Essex : 1987) 2025 Mar 1;368:125779
Environmental pollution (Barking, Essex : 1987) 2025 Mar 1;368:125779
Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis.
Chen J, Shen Z, Chen B, Liu S, Mei Y, Li K, Peng Z, Feng C, Wang W, Lu S
Stem cell research & therapy 2025 Mar 1;16(1):105
Stem cell research & therapy 2025 Mar 1;16(1):105
Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis.
Tu C, Qian C, Li S, Lin DY, Liu ZY, Ouyang WG, Kang XL, Chen F, Song S, Cai SQ
Nature aging 2025 Jun;5(6):1063-1078
Nature aging 2025 Jun;5(6):1063-1078
Natural compound PEITC inhibits gain of function of p53 mutants in cancer cells by switching YAP-binding partners between p53 and p73.
Wang YX, Wang LW, Huang Y, Zhou L, Li GY, Yang JW, Wu XF, Cheng JC, Xu Q, Shen Y
Acta pharmacologica Sinica 2025 Jun;46(6):1722-1732
Acta pharmacologica Sinica 2025 Jun;46(6):1722-1732
Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction.
Zhao HM, Mu LQ, Wang J, Chen RZ, Li Y, Zhao L, Zhao Y, Liu LN
Current medical science 2025 Jun;45(3):469-480
Current medical science 2025 Jun;45(3):469-480
Rictor orchestrates β-catenin/FOXO balance by maintaining redox homeostasis during development of ovarian cancer.
Zhao X, Lai H, Li G, Qin Y, Chen R, Labrie M, Stommel JM, Mills GB, Ma D, Gao Q, Fang Y
Oncogene 2025 Jun;44(23):1820-1832
Oncogene 2025 Jun;44(23):1820-1832
Targeting KPNB1 suppresses AML cells by inhibiting HMGB2 nuclear import.
Xie Y, Zhao R, Zheng Y, Li Y, Wu F, Lei Y, Li L, Zeng H, Chen Z, Hou Y
Oncogene 2025 Jun;44(21):1646-1661
Oncogene 2025 Jun;44(21):1646-1661
Human Umbilical Cord Mesenchymal Stem Cells Alleviate Diabetic Nephropathy by Inhibiting Ferroptosis via the JNK/KEAP1/NRF2 Signaling Pathway.
Zhu Y, Dong C, Xu Z, Lou Y, Tian N, Guan Y, Nie P, Luo M, Luo P
Antioxidants & redox signaling 2025 Jun;42(16-18):807-826
Antioxidants & redox signaling 2025 Jun;42(16-18):807-826
Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment.
Fan Y, Niu Z, Yin L, Yao L, Ding S, Tong Y, Wang J, Hong Z, Chen J, Zhang Q, Ji L, Chen J, Xia C, Bi Q
Materials today. Bio 2025 Jun;32:101778
Materials today. Bio 2025 Jun;32:101778
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L, Gao P, Zhang H
Nature chemical biology 2025 Jun;21(6):926-938
Nature chemical biology 2025 Jun;21(6):926-938
Targeted lipidomic reveals dietary LA/n-3 PUFAs regulate inflammation and redox status via oxylipins in bivalves.
Zhu Y, Liao K, Liu Y, Huang H, Zhang Y, Ge H, Chen D, Ma B, Xu J
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159631
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159631
LuQi formula ameliorates pressure overload-induced heart failure by regulating macrophages and regulatory T cells.
Wang X, Liu Q, Cheng P, Yang T, Zhao T, Liu M, Dai E, Sha W, Yuan J, Rong J, Qu H, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156527
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156527
Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways.
Meng F, He J, Zhang X, Lyu W, Wei R, Wang S, Du Z, Wang H, Bi J, Hua X, Zhang C, Guan Y, Lyu G, Tian XL, Zhang L, Xie W, Tao W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(22):e2412747
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(22):e2412747
Sulforaphane Promotes the Skeletal Muscle Postinjury Regeneration by Up-Regulating the Transcription of Prl2c2 through JAK2/STAT3 Signaling.
Li S, Yu H, Teng H, Zhang L, Li R, Tong H
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13502-13515
Journal of agricultural and food chemistry 2025 Jun 4;73(22):13502-13515
Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation.
Zhou C, Dong X, Li S, Xi Y, Liu Y, Qian X, Song Z, Zhou L, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Liu W, Xiong Y, Wang Z, Yan C, Zhang Z, Zhu H, Chen XZ, Song Z, Tang J
Signal transduction and targeted therapy 2025 Jun 30;10(1):205
Signal transduction and targeted therapy 2025 Jun 30;10(1):205
Tumor-intrinsic TTLL12 drives resistance to cancer immunotherapy via modulating myeloid-derived suppressor cells.
Chen DW, Cheng YK, Li PS, Wu XJ, Huang XX, Long JH, Xiong Z, Chen C, Ye SB, Lan P
Journal for immunotherapy of cancer 2025 Jun 3;13(6)
Journal for immunotherapy of cancer 2025 Jun 3;13(6)
Piezo1 disrupts blood-brain barrier via CaMKII/Nrf2 in ischemic stroke.
Fu H, Yu Y, Wang S, Xu P, Sun Y, Li J, Ge X, Pan S
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):259
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):259
Novel drug-inducible CRISPRa/i systems for rapid and reversible manipulation of gene transcription.
Sui M, Zhou M, Cui M, Liu H, Zhang X, Hu N, Li Y, Wang B, Yang G, Gui P, Zhu L, Wan F, Zhang B
Cellular and molecular life sciences : CMLS 2025 Jun 23;82(1):249
Cellular and molecular life sciences : CMLS 2025 Jun 23;82(1):249
ISCU-p53 axis orchestrates macrophage polarization to dictate immunotherapy response in esophageal squamous cell carcinoma.
Luo J, Zhang X, Liang Z, Zhuang W, Jiang M, Ma M, Peng S, Huang S, Qiao G, Chen Q
Cell death & disease 2025 Jun 20;16(1):462
Cell death & disease 2025 Jun 20;16(1):462
Identification of CD84 as a potent survival factor in acute myeloid leukemia.
Zhu Y, Murtadha M, Liu M, Caserta E, Napolitano O, Nguyen LXT, Wang H, Moloudizargari M, Nigam L, Tandoh T, Wang X, Pozhitkov A, Su R, Lin X, Estepa MD, Pillai R, Song J, Sanchez JF, Fu YH, Zhang L, Li M, Zhang B, Li L, Kuo YH, Rosen S, Marcucci G, Williams JC, Pichiorri F
The Journal of clinical investigation 2025 Jun 2;135(11)
The Journal of clinical investigation 2025 Jun 2;135(11)
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Chen W, Li D, Chen L, Fei J, Bian M, Zeng Q, Jiang Z, Wu J
Arthritis research & therapy 2025 Jun 19;27(1):128
Arthritis research & therapy 2025 Jun 19;27(1):128
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
Son SM, Siddiqi FH, Lopez A, Ansari R, Tyrkalska SD, Park SJ, Kunath T, Metzakopian E, Fleming A, Rubinsztein DC
Neuron 2025 Jun 18;113(12):1908-1924.e13
Neuron 2025 Jun 18;113(12):1908-1924.e13
LMNB1 regulates breast cancer cell senescence and migration through PPAR signaling pathway.
Meng S, Liu S, Liu C, Yang K, Lai M
Discover oncology 2025 Jun 14;16(1):1103
Discover oncology 2025 Jun 14;16(1):1103
Meloxicam Alleviates Oxidative Stress Through Nrf2/HO-1 Activation in Bovine Endometrial Epithelial Cells.
Cui L, Duan J, Mao P, Zhong J, He S, Dong J, Liu K, Guo L, Li J, Wang H
Veterinary sciences 2025 Jun 12;12(6)
Veterinary sciences 2025 Jun 12;12(6)
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy.
Zhang M, Wei Z, Wei B, Lai C, Zong G, Tao E, Fan M, Pan Y, Zhou B, Shen L, Wu J, Wang Q, Peng Y, Zhen L, Wu Y, Lu Y, Wang G, Zhou F, Shan Y
Cell host & microbe 2025 Jun 11;33(6):915-931.e9
Cell host & microbe 2025 Jun 11;33(6):915-931.e9
CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models.
Surdyka M, Kalinowska-Pośka Ż, Niewiadomska-Cimicka A, Jesion E, Fiszer A, Singer-Mikosch E, Fievet L, Przybyl L, Caron NS, Hayden MR, Nguyen HP, Trottier Y, Figiel M
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102496
Molecular therapy. Nucleic acids 2025 Jun 10;36(2):102496
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
Li Q, Huang Y, Ban T, Chen K, Zhen X, Dai Q, Zhang G
Neuropharmacology 2025 Jun 1;270:110374
Neuropharmacology 2025 Jun 1;270:110374
MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.
Li X, Zhan F, Qiu G, Lu P, Shen Z, Qi Y, Wu M, Chu M, Feng J, Wen Z, Yao X, Wang A, Jin W, Zhang X, Liao J, Zhang J, Song M, Wang W, Wang X
Redox biology 2025 Jul;84:103681
Redox biology 2025 Jul;84:103681
Pilot Exploration of RGMa-BMP4 Signaling in Neutrophil Activation in NMOSD: Integrating Clinical and Molecular Insights.
Zhang W, Cui L, Zhang Y, He Y, Li X, Wang Y, Jiao J, Peng D, Jin M, Xiao C
Molecular neurobiology 2025 Jul;62(7):9151-9161
Molecular neurobiology 2025 Jul;62(7):9151-9161
YY1/HIF-1α/mROS positive-feedback loop exacerbates glomerular mesangial cell proliferation in mouse early diabetic kidney disease.
Yang TT, Shao YT, Cheng Q, He YT, Qiu Z, Pan DD, Zhang HM, Jiang ZZ, Yan M, Ying CJ, Li BJ, Liu JJ, Qian ST, Wang T, Yin XX, Lu Q
Acta pharmacologica Sinica 2025 Jul;46(7):1974-1989
Acta pharmacologica Sinica 2025 Jul;46(7):1974-1989
Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A.
Hu H, Zhan X, Xiong Y, Yuan R, Du Y, Dong Q, Li S, Guo B, Li Z, Feng J, Xiong S, Xiong J, Li D, Fu B, Xu S, Guo J
Oncogene 2025 Jul;44(28):2372-2385
Oncogene 2025 Jul;44(28):2372-2385
TP53INP2 promotes mitophagic degradation of YAP to impede dedifferentiated liposarcoma development.
Wang Y, Huang Y, Wang L, Chen Z, Zhou L, Xiang F, Li G, Yang J, Chen R, Xu Q, Shen Y
Oncogene 2025 Jul;44(25):2054-2063
Oncogene 2025 Jul;44(25):2054-2063
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
Ma MQ, Yang C, Jin SY, Yang Y, Pan YY, Lin XH
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma.
Yu H, Du Y, He Y, Sun Y, Li J, Jia B, Chen J, Peng X, An T, Li J, Chi Y, Wang M, Cao L, Tai Y, Zhai X, Nuersulitan R, Li S, Wu N, Wang J, Xiong H, Wan S, Liu J, Yang X, Hu X, Lin D, Sun W, Wang Y, An G, Ji X, Kong L, Ding L, Ma Y, Tian Z, Dong B, Bi Y, Wu J, Wang Z
Cell host & microbe 2025 Jul 9;33(7):1089-1105.e7
Cell host & microbe 2025 Jul 9;33(7):1089-1105.e7
Adipose-derived stem cells alleviate acute pancreatitis by inhibiting ferroptosis and oxidative damage in canines.
Ge Y, Chen M, Li M, Wang Z, Ding R, Wan Z, Xu E, Zheng J
Stem cell research & therapy 2025 Jul 7;16(1):355
Stem cell research & therapy 2025 Jul 7;16(1):355
Irisin attenuates liver fibrosis by regulating energy metabolism and HMGB1/β-catenin signaling in hepatic stellate cells.
Li F, Liu X, Bai N, Li Y, Hou M, Hou Y, Liu Y, Wang X, He Q, Li J
European journal of pharmacology 2025 Jul 5;998:177519
European journal of pharmacology 2025 Jul 5;998:177519
MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction.
Ding Z, Wang R, Li Y, Wang X
Molecular cell 2025 Jul 3;85(13):2610-2625.e5
Molecular cell 2025 Jul 3;85(13):2610-2625.e5
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects.
Wang Z, Liu J, Mou Y, Zhou X, Liao W, Li Y, Liu Y, Tang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156904
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156904
Comprehensive multi-omics and pharmacokinetics reveal sclareol's role in inhibiting ocular neovascularization.
Yang CC, Jiang Q, Xue JS
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156817
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156817
DNA damage response pathway regulates Nrf2 in response to oxidative stress.
Jiang XY, Guo QQ, Wang SS, Guo R, Zou Y, Liu JW, Feng YL, Guo Y, Li YH, Liu XY, Zhang XY, Hao S, Wu XX, Li MH, Liu A, Li CL, Guo WD, Xu HD, Song XY, Finkel T, Cao L
Science advances 2025 Jul 25;11(30):eadu9555
Science advances 2025 Jul 25;11(30):eadu9555
Histone marks enable formation of immiscible phase-separated chromatin compartments.
Sun W, Wang J, Liu W, Tang B, Qu H, Su H, Wang J, Li H, Xie W, Li P
Cell reports 2025 Jul 22;44(7):116003
Cell reports 2025 Jul 22;44(7):116003
CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism.
Liu M, Gong Y, Cai H, Hua R, Li H, Wang Z, Zhou Y, Ma Y, Quan S
Journal of translational medicine 2025 Jul 10;23(1):763
Journal of translational medicine 2025 Jul 10;23(1):763
E3 ligase TRIM22 promotes melanoma proliferation by regulating cell cycle progression through K63-linked ubiquitination of p21.
Jin CX, Feng TZ, Ji X, Liu YS, Qin HN, Teng YB, Sampson C, Xia T, Piao HL, Liu JW
Scientific reports 2025 Jul 1;15(1):22311
Scientific reports 2025 Jul 1;15(1):22311
The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling.
Xia F, Zhang Z, Qian Z, Fang X, Wang J, Wang Y, Sun G, Yu Y, Wang N, Zhen J, Liu Y, Lu Y
Molecular metabolism 2025 Jan;91:102069
Molecular metabolism 2025 Jan;91:102069
The serine protease DPP9 and the redox sensor KEAP1 form a mutually inhibitory complex.
Tsamouri LP, Hsiao JC, Bachovchin DA
The Journal of biological chemistry 2025 Jan;301(1):108034
The Journal of biological chemistry 2025 Jan;301(1):108034
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint.
Hervé S, Scelfo A, Bersano Marchisio G, Grison M, Vaidžiulytė K, Dumont M, Angrisani A, Keikhosravi A, Pegoraro G, Deygas M, P F Nader G, Macé AS, Gentili M, Williart A, Manel N, Piel M, Miroshnikova YA, Fachinetti D
Nature cell biology 2025 Jan;27(1):73-86
Nature cell biology 2025 Jan;27(1):73-86
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
Sun J, Ding J, Yue H, Xu B, Sodhi A, Xue K, Ren H, Qian J
Autophagy 2025 Jan;21(1):191-209
Autophagy 2025 Jan;21(1):191-209
Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1.
Lv C, Wang S, Sun C, Liu J, Chen Y, Wang C, Yuan C, Qin F, Li T
Food science & nutrition 2025 Jan;13(1):e4768
Food science & nutrition 2025 Jan;13(1):e4768
STIM1 promotes cervical cancer progression through autophagy activation via TFEB nuclear translocation.
Luo X, Jian M, Wu P, Wu Y, Ma Y, Feng N, Lu M, Shi D, Liu R, Ding Y, Zhang W, Fan L, He X
Cellular signalling 2025 Jan;125:111500
Cellular signalling 2025 Jan;125:111500
Protective Effects of α-Linolenic Acid on Liver Inflammation and Oxidative Stress Induced by Lipopolysaccharide in Broilers.
Cheng X, Zhang X, Ni J, Ding H, Ma W, Wang D
Animal science journal = Nihon chikusan Gakkaiho 2025 Jan-Dec;96(1):e70096
Animal science journal = Nihon chikusan Gakkaiho 2025 Jan-Dec;96(1):e70096
Bardoxolone methyl triggers Ferroptosis in cardiomyocytes.
Li H, Hong M, Liu Y, Rahman SU, Li X, Zheng F
Human & experimental toxicology 2025 Jan-Dec;44:9603271251394706
Human & experimental toxicology 2025 Jan-Dec;44:9603271251394706
Pedunculoside inhibits cardiomyocyte inflammatory biomarkers via Nrf2/HO-1 pathway in high glucose-induced H9c2 cells and diabetic cardiomyopathy model rats.
Lu Y, Meng J, Zhu D, Jiang Z, Ma H
Human & experimental toxicology 2025 Jan-Dec;44:9603271251322186
Human & experimental toxicology 2025 Jan-Dec;44:9603271251322186
5-(3-(N-(Carboxymethyl)naphthalene-2-sulfonamido)phenyl)-1-ethyl-1H-pyrrole-2-carboxylic acid as a Keap1-Nrf2 inhibitor for cerebral ischemia/reperfusion injury treatment.
Cairang N, Wu Y, Zhi S, Tang J, Tie X, Zhan D, Lu G, Shi Y, Zhao Q
RSC advances 2025 Jan 9;15(2):1052-1059
RSC advances 2025 Jan 9;15(2):1052-1059
Processed Buthus martensii Karsch scorpions ameliorate diet-induced NASH in mice by attenuating Kv1.3-mediated macrophage activation.
Xu E, Sang M, Xu W, Chen Y, Wang Z, Zhang Y, Lu W, Cao P
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118794
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118794
Supplementation with carnosine, a food-derived bioactive dipeptide, alleviates dexamethasone-induced oxidative stress and bone impairment via the NRF2 signaling pathway.
Li XY, Gu XY, Li XM, Yan JG, Mao XL, Yu Q, Du YL, Kurihara H, Yan CY, Li WX
Journal of the science of food and agriculture 2025 Jan 30;105(2):1091-1104
Journal of the science of food and agriculture 2025 Jan 30;105(2):1091-1104
Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages.
Hou SM, Yang CM, Huang WC, Cheng SW, Yen TL, Hsia CW, Hsieh CY, Hsia CH
Biomolecules 2025 Jan 24;15(2)
Biomolecules 2025 Jan 24;15(2)
Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent m(6)A regulation.
Xu L, Zhang L, Sun Q, Zhang X, Zhang J, Zhao X, Hu Z, Zhang S, Shi F
Cellular and molecular life sciences : CMLS 2025 Jan 23;82(1):60
Cellular and molecular life sciences : CMLS 2025 Jan 23;82(1):60
PKM2-mediated collagen XVII expression is critical for wound repair.
Liu Y, Ho C, Wen D, Sun J, Liu Y, Li Q, Zhang Y, Gao Y
JCI insight 2025 Jan 21;10(4)
JCI insight 2025 Jan 21;10(4)
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA.
Yang J, Bu J, Liu B, Liu Y, Zhang Z, Li Z, Lu F, Zhu B, Li Y
Nature communications 2025 Jan 2;16(1):248
Nature communications 2025 Jan 2;16(1):248
Drug-induced senescence of donor dermal fibroblasts enhances revascularization and graft success in skin transplantation.
Li Z, Wang Y, Yang Z, Pang J, Song L, Liu C, Zhang J, Dong L
European journal of pharmacology 2025 Jan 15;987:177208
European journal of pharmacology 2025 Jan 15;987:177208
Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.
Yin L, He Z, Fan Y, Niu Z, Yao L, Ding S, Chen J, Zhang Q, Tong Y, Bi Q, Cao L
International immunopharmacology 2025 Jan 10;144:113695
International immunopharmacology 2025 Jan 10;144:113695
The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
Jiang Y, He P, Sheng K, Peng Y, Wu H, Qian S, Ji W, Guo X, Shan X
eLife 2025 Jan 10;13
eLife 2025 Jan 10;13
Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival.
Villagomez FR, Lang J, Nunez-Avellaneda D, Behbakht K, Dimmick HL, Webb PG, Nephew KP, Neville M, Woodruff ER, Bitler BG
Cancer research communications 2025 Jan 1;5(1):39-53
Cancer research communications 2025 Jan 1;5(1):39-53
Proline exacerbates hepatic gluconeogenesis via paraspeckle-dependent mRNA retention.
Zhao Y, Chai X, Peng J, Zhu Y, Dong R, He J, Xia L, Liu S, Chen J, Xu Z, Luo C, Sheng J
Nature metabolism 2025 Feb;7(2):367-382
Nature metabolism 2025 Feb;7(2):367-382
AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane.
Pan Y, Yin Q, Wang Z, Wu G, Liu K, Li X, Liu J, Zeng J, Lin B, Li W, Zhu M, Li M
Translational oncology 2025 Feb;52:102240
Translational oncology 2025 Feb;52:102240
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression.
Zhu Y, Zhao L, Yan W, Ma H, Zhao W, Qu J, Zheng W, Zhang C, Du H, Yu M, Wan N, Ye H, Xie Y, Ke B, Xu Q, Sun H, Sun Y, Ouyang Z
Acta pharmaceutica Sinica. B 2025 Feb;15(2):876-891
Acta pharmaceutica Sinica. B 2025 Feb;15(2):876-891
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury.
Zeng L, Wang Y, Huang Y, Yang W, Zhou P, Wan Y, Tao K, Li R
Cell communication and signaling : CCS 2025 Feb 5;23(1):63
Cell communication and signaling : CCS 2025 Feb 5;23(1):63
Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea.
Lin Z, Feng Y, Wang J, Men Z, Ma X
Microbiome 2025 Feb 4;13(1):36
Microbiome 2025 Feb 4;13(1):36
Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways.
Han F, Wang L, Wu J, Shen L, Li Y, Guo H, Li J
Investigative ophthalmology & visual science 2025 Feb 3;66(2):13
Investigative ophthalmology & visual science 2025 Feb 3;66(2):13
Circ-Sirt6 promotes the stability and expression of m(6)A modified Sirt6 mRNA by recruiting IGF2BP2.
Zhang C, Wang J, Kong P, Sun G, Sun H, Yu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 28;39(4):e70405
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 28;39(4):e70405
NUP98-p65 complex regulates DNA repair to maintain glioblastoma stem cells.
Li F, Zhang Y, Li J, Jiang R, Ci S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 28;39(4):e70401
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 28;39(4):e70401
The Polybrominated Diphenyl Ether Bromoxib Disrupts Nuclear Import and Export by Affecting Nucleoporins of the Nuclear Pore Complex.
Krings KS, Ritchie A, Schmitt L, Hatzfeld J, Totzke G, Lenz T, Mendiburo MJ, Stork B, Teusch N, Proksch P, Stühler K, Müller L, Wesselborg S
Marine drugs 2025 Feb 28;23(3)
Marine drugs 2025 Feb 28;23(3)
CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity.
Wang DM, Yang J, Ansari MO, Arbieva Z, Maienschein-Cline M, Natarajan V, Malik AB, Tiruppathi C
bioRxiv : the preprint server for biology 2025 Feb 27;
bioRxiv : the preprint server for biology 2025 Feb 27;
8q24 derived ZNF252P promotes tumorigenesis by driving phase separation to activate c-Myc mediated feedback loop.
Qu T, Zhang C, Lu X, Dai J, He X, Li W, Han L, Yin D, Zhang E
Nature communications 2025 Feb 26;16(1):1986
Nature communications 2025 Feb 26;16(1):1986
Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3.
Ye L, Shen S, Mao Q, Lu H, Liu H, Zhang P, Jiang Z, Ma W, Sun Y, Chu Y, Zhou Z, Liu R, Li J, Li ST, Gao P, Zhang H
Cell reports 2025 Feb 25;44(2):115250
Cell reports 2025 Feb 25;44(2):115250
Tumor vascular endothelial cells promote immune escape by upregulating PD-L1 expression via crosstalk between NF-κB and STAT3 signaling pathways in nasopharyngeal carcinoma.
Wang Y, Chen Y, Liu Y, Zhao J, Wang G, Chen H, Tang Y, Ouyang D, Xie S, You J, Yang X, Li M, Xia J, Xiang T, Weng D
Cell death & disease 2025 Feb 25;16(1):129
Cell death & disease 2025 Feb 25;16(1):129
Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer.
Wang Y, Peng Y, Hao W, He C, Gao X, Liang P, Zhao H, Wang Y, Wang L, Yu Z, Liu Z
iScience 2025 Feb 21;28(2):111505
iScience 2025 Feb 21;28(2):111505
Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling.
Yu J, Li Y, Li Y, Liu X, Huo Q, Wu N, Zhang Y, Zeng T, Zhang Y, Li HY, Lian J, Zhou J, Moses EJ, Geng J, Lin J, Li W, Zhu X
Nature communications 2025 Feb 21;16(1):1865
Nature communications 2025 Feb 21;16(1):1865
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction.
Xu H, Wei K, Ni J, Deng X, Wang Y, Xiang T, Song F, Wang Q, Niu Y, Jiang F, Wang J, Sheng L, Dai J
Bone research 2025 Feb 14;13(1):23
Bone research 2025 Feb 14;13(1):23
Human iPSC-Derived Muscle Cells as a New Model for Investigation of EDMD1 Pathogenesis.
Lisowska M, Rowińska M, Suszyńska A, Bearzi C, Łaczmańska I, Hanusek J, Kunik A, Dzianisava V, Rzepecki R, Machowska M, Piekarowicz K
International journal of molecular sciences 2025 Feb 12;26(4)
International journal of molecular sciences 2025 Feb 12;26(4)
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
Hu X, Li J, Ding C, Jiang J, Xia W, Lu J, Su H, Zhang M, Li H, Liu JL, Lin Y, Meng Q, Huang B
Communications biology 2025 Feb 11;8(1):215
Communications biology 2025 Feb 11;8(1):215
Inhibition of SCF(KDM2A)/USP22-dependent nuclear β-catenin ubiquitylation mediates cerebral ischemic tolerance.
Zuo Y, Xue J, Wen H, Zhan L, Chen M, Sun W, Xu E
Communications biology 2025 Feb 11;8(1):214
Communications biology 2025 Feb 11;8(1):214
Cepharanthine relieves nonalcoholic steatohepatitis through inhibiting STAT1/CXCL10 axis-mediated lipogenesis and inflammatory responses.
Li P, Zhang R, Hu P, Wang T, Wang J
Journal of ethnopharmacology 2025 Feb 11;341:119358
Journal of ethnopharmacology 2025 Feb 11;341:119358
Electroacupuncture ameliorated locomotor symptoms in MPTP-induced mice model of Parkinson's disease by regulating autophagy via Nrf2 signaling.
Zhang J, Fu Z, Wen F, Lyu P, Huang S, Cai X, Zhang Z, Zhang Y, Fan C, Man W, Sun X, Huang Y
Journal of neurophysiology 2025 Feb 1;133(2):490-501
Journal of neurophysiology 2025 Feb 1;133(2):490-501
SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation.
Wei L, Kang M, Zhang G, Meng Y, Qin H
Inflammation 2025 Dec;48(6):3858-3877
Inflammation 2025 Dec;48(6):3858-3877
Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.
Shen D, Lin L, Su Y, Xu J, Jiang W, Zhang Z, Fang Y, Ding X, Xu X
Renal failure 2025 Dec;47(1):2499897
Renal failure 2025 Dec;47(1):2499897
Regulation of nuclear transport of the transcriptional factor REST improves axon regeneration in peripheral nerves.
Suzuki T, Naito K, Kubota D, Ueno Y, Negishi-Koga T, Yamamoto Y, Kawakita S, Imazu N, Kawamura K, Hattori N, Ishijima M
Molecular medicine reports 2025 Dec;32(6)
Molecular medicine reports 2025 Dec;32(6)
YAP-mediated glycolysis promotes pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension.
Shi W, Chen L, Zhang W, He P, Zhang Y, Yan K, Li C, Ning P, Liu Y, Ma S, Ke R
The Journal of biological chemistry 2025 Dec;301(12):110836
The Journal of biological chemistry 2025 Dec;301(12):110836
Lipopolysaccharide-induced cytokine signaling activates a temporal innate defense program and represses pancreatic β-cell identity.
Bartosiak JT, Hansen PA, Schumacher EA, Harty KR, Stancill JS, Corbett JA
The Journal of biological chemistry 2025 Dec;301(12):110811
The Journal of biological chemistry 2025 Dec;301(12):110811
Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2.
Yao H, Wu R, Du D, Ai F, Yang F, Li Y, Qi S
Redox report : communications in free radical research 2025 Dec;30(1):2440204
Redox report : communications in free radical research 2025 Dec;30(1):2440204
Stage-specific TRIM10 expression regulates erythroid maturation.
Kim H, Shin W, Lee D, Jeon B, Kim Y, Shin D, Jeong H, Hong JY, Lee S, Park B
EMBO reports 2025 Dec;26(23):5982-6014
EMBO reports 2025 Dec;26(23):5982-6014
Targeting MORF4L1-mediated DNA repair potentiates RT-induced antitumor immunity via cGAS-STING activation in hepatocellular carcinoma.
Wang SW, Hong WF, Huang YL, Zheng YM, Zheng QY, Cheng JJ, Tang BF, Chen GW, Liang BG, Lu JC, Yuan L, Hsu SJ, Zhang Y, Zheng XB, Zeng ZC, Zhou J, Fan J, Ke AW, Gao C, Du SS
Cellular & molecular immunology 2025 Dec;22(12):1549-1566
Cellular & molecular immunology 2025 Dec;22(12):1549-1566
Inflammatory signaling attenuates spliceosome function and cognitive ability.
Lin L, Huang X, Huang C, Zou J, Hu M, Lan T, Wang H, Du Z, Tian M, Liu J, Dong H, Liu B, Cheng H, Zhou L, Chen Y, Zhou R
Autophagy 2025 Dec;21(12):3123-3141
Autophagy 2025 Dec;21(12):3123-3141
Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation.
Xiang Z, Li X, Wang X, Deng B, He H, Xu M, Wu X, Tan C, Liu Y, Yu B, Zhang J, Dong W
Gut microbes 2025 Dec;17(1):2489070
Gut microbes 2025 Dec;17(1):2489070
Human bocavirus NP1 antagonizes host type I interferon response through repressing the nuclear transport of STAT1.
Xue M, Huang C, Jiang X, Zhou S, Yan Y, Dong C, Chen Z, Dai J
Virulence 2025 Dec;16(1):2570000
Virulence 2025 Dec;16(1):2570000
Reactivating T cell immunity in Wnt-hyperactivated non-small cell lung cancer through a supramolecular droplet of carnosic acid and peptide.
Liu N, Tu Y, Wang H, Zheng X, Ji F, Geng M, Wei X, Xin J, He W, Zhao Q, Liu T
Journal of pharmaceutical analysis 2025 Dec;15(12):101309
Journal of pharmaceutical analysis 2025 Dec;15(12):101309
RIPK1 Drives JAK1-STAT3 Signaling to Promote CXCL1-Mediated Neutrophil Recruitment in Sepsis-Induced Lung Injury.
Sun H, Li X, Gao S, Jiang Y, Wu X, Chen Z, Wu H, Hua Q, Zu R, Xiang H, Ben-Ami R, Miao C, Tan L, Li Y, Wang J, Chen W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e07123
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e07123
Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy.
Dzianisava V, Piekarowicz K, Machowska M, Rzepecki R
Molecular therapy. Nucleic acids 2025 Dec 9;36(4):102727
Molecular therapy. Nucleic acids 2025 Dec 9;36(4):102727
Luteolin rescues myelin integrity and cognitive-motor function via Nrf2 pathway activation: a natural candidate vs. dimethyl fumarate in cuprizone-induced multiple sclerosis.
Tian H, Zhang Y, Xiao S, Cai J, Qi H, Zhang B, Chen Z, Cheng Y
Nutritional neuroscience 2025 Dec 8;:1-17
Nutritional neuroscience 2025 Dec 8;:1-17
FAM189A2 activates Hippo signaling pathway by abrogating WWP2-mediated LATS1 ubiquitination, to inhibit the glycolysis and proliferation processes of lung adenocarcinoma.
Chen B, Rong X, Feng Y, Hou Y, Fu L, Han Q, Song Y, Lin X
Journal of translational medicine 2025 Dec 5;24(1):48
Journal of translational medicine 2025 Dec 5;24(1):48
Melatonin Supplementation Relieves Fluoride-Induced Bone Injury via Ion Homeostasis Disorder and PINK1/Parkin-Mediated Mitophagy.
Zhuang C, Zhao J, Zhang X, Guo M, Lu Y, Pei T, Zhao Y, Liang C, Zhang J
Foods (Basel, Switzerland) 2025 Dec 5;14(24)
Foods (Basel, Switzerland) 2025 Dec 5;14(24)
UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression.
Cai G, Zhang Z, Zhong L, Wang H, Miao M, Su J, An Y, Zhang C, Luo X, Ju HQ, Zhang J, Huang W, Li Z, Liu P, Wu D, Chan FL, Zhou H, Han F, Chen HW, Su T, Wang J
Molecular cell 2025 Dec 4;85(23):4347-4364.e12
Molecular cell 2025 Dec 4;85(23):4347-4364.e12
Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway.
Zeng Q, Liao ML, Luo YY, Li S, You G, Huang CM, Liu MH, Liu W, Tang SY
International journal of molecular sciences 2025 Dec 30;27(1)
International journal of molecular sciences 2025 Dec 30;27(1)
Gpr109a alleviates mammary fibrosis via PPARγ-mediated reduction of ROS and mitochondrial damage.
Bi J, He D, Li F, Xu P, Huang Y, Guo W, Fu S, Kan X, Li Y
International immunopharmacology 2025 Dec 3;166:115603
International immunopharmacology 2025 Dec 3;166:115603
Bruceine D promotes TNBC regression by inhibiting M2-like tumor-associated macrophage polarization induced Wnt3a/β-catenin pathway.
Ma Y, Cao D, Han X, Hu Z, Ding X, Wang J
International immunopharmacology 2025 Dec 3;166:115596
International immunopharmacology 2025 Dec 3;166:115596
Sofalcone inhibits osteoclastogenesis through Keap1/Nrf2 signaling activation and mitigates ovariectomy-induced bone loss.
Liang H, Wu Q, Hua T, Chen Y, Luo J, Miao J, Su H, Yang S, Xu J, Wang X, Jin H
International immunopharmacology 2025 Dec 3;166:115589
International immunopharmacology 2025 Dec 3;166:115589
Uptake mechanisms and functions of isolated mitochondria in mesenchymal stromal cells.
Kanai M, Goto M, Itakura S, Nishikawa M, Kusamori K
Scientific reports 2025 Dec 29;15(1):44799
Scientific reports 2025 Dec 29;15(1):44799
Butin inhibits osteoarthritis progression by modulating the Nrf2/HO-1 signaling pathway and inhibiting NF-κB signaling.
Zhou P, Chang J, Wei X, Zhu C, Yang J, Wang C, Hu Y, Zhang C
Scientific reports 2025 Dec 26;15(1):45688
Scientific reports 2025 Dec 26;15(1):45688
Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration.
Mahmud J, Nandi I, J Procter D, Walsh D
Proceedings of the National Academy of Sciences of the United States of America 2025 Dec 2;122(48):e2507831122
Proceedings of the National Academy of Sciences of the United States of America 2025 Dec 2;122(48):e2507831122
Nonsense-mediated mRNA decay inhibits TRAF6-dependent anti-tumor immunity in colorectal cancer.
Wang Y, Wang Z, Wang C, Wu Y, Li J, Feng L, Hao M, Jin H, Zhou J, Wang X
Cell reports. Medicine 2025 Dec 16;6(12):102463
Cell reports. Medicine 2025 Dec 16;6(12):102463
Gut microbiome-derived indole-3-carboxaldehyde promotes intestinal development via AHR-NRF2 signaling in the early-life of chicks.
Huang YX, Deng ZC, Cao KX, Yang JC, Liu M, Zhao L, Zheng JS, Sun LH
Microbiome 2025 Dec 16;14(1):34
Microbiome 2025 Dec 16;14(1):34
Early life exposure to environmental levels of PCB138 induces lipid metabolism disorders through activating aryl hydrocarbon receptor in female mice.
Zhu S, He R, Ruan J, Chen P, Zhang Y, Yang C, Wang W, He C, Zuo Z
Environmental research 2025 Dec 15;287:123038
Environmental research 2025 Dec 15;287:123038
Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus.
Tao L, Teng L, Ge M, Wang Y, Hu C, Chen J, Zhao J, Cheng L, Zhang Z, Qin W, Jia Y, Mi D, Yuan Z, Chen L
Nature communications 2025 Dec 15;16(1):11117
Nature communications 2025 Dec 15;16(1):11117
Endothelial mechanosensitive transcription factor BHLHE40 induced by Piezo1 suppresses endothelial ferroptosis and inflammation via SLC7A11.
Miao S, Dai X, Li X, Chen Z, Wang Y, Ye T, Ying Y, Yu Y, Wu A, Song H, Teng P, Ma L, Zheng Q
Cell death discovery 2025 Dec 10;12(1):47
Cell death discovery 2025 Dec 10;12(1):47
LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity.
Li JY, Li YQ, Dai JH, Gong S, He QM, Bai JW, Huang SW, Lu YQ, Duan YF, Feng SY, Tan XR, Liang XY, Ma J, Guo R, Liu N
The Journal of clinical investigation 2025 Dec 1;135(23)
The Journal of clinical investigation 2025 Dec 1;135(23)
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation.
Song ML, Sun YY, Yin HJ, Li Y, Yang H
Acta pharmacologica Sinica 2025 Aug;46(8):2136-2150
Acta pharmacologica Sinica 2025 Aug;46(8):2136-2150
SDF2L1 downregulation mediates high glucose-caused Schwann cell dysfunction by inhibiting nuclear import of TFEB and CREB via KPNA3.
Jin T, Li F, Wei W, Li Q, Gao Y, Yuwen C, Sun Y, Li W, Zhu L, Hao J
Experimental neurology 2025 Aug;390:115273
Experimental neurology 2025 Aug;390:115273
Tianma Granules Alleviate AOM/DSS-Induced Colorectal Tumorigenesis by Inhibiting the Wnt/β-Catenin Pathway Activation.
Lin R, Xiao J, Chen Y, Li X, Zhang P, Zhang R, Luo M
Journal of cellular and molecular medicine 2025 Aug;29(15):e70772
Journal of cellular and molecular medicine 2025 Aug;29(15):e70772
Discovery of a novel polyketide-derived ferroptosis inhibitor from endophytic fungus Ophiobolus cirsii LZU-1509 with therapeutic potential in ischemic stroke.
Xi J, Ren H, Zhang W, Wang Z, Zhao H, Wu QX, Fang J
Bioorganic chemistry 2025 Aug;163:108656
Bioorganic chemistry 2025 Aug;163:108656
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.
Yan J, Wang T, Yu R, Xu L, Shao H, Li T, Wang Z, Cha X, Miao Z, Xing C, Xu K, Liu H, Zhuang C
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4137-4155
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4137-4155
SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy.
Dong L, Yang Z, Liu J, Wu R, Liao Y, Kuang L
Cellular signalling 2025 Aug;132:111840
Cellular signalling 2025 Aug;132:111840
RONIN/HCF1-TFEB Axis Protects Against D-Galactose-Induced Cochlear Hair Cell Senescence Through Autophagy Activation.
Wei Y, Zhang Y, Cao W, Cheng N, Xiao Y, Zhu Y, Xu Y, Zhang L, Guo L, Song J, Sha SH, Shao B, Ma F, Yang J, Ying Z, He Z, Chai R, Fang Q, Yang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e2407880
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e2407880
LIMK1 as a Novel Kinase of β-Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5.
Li SJ, Liang ZR, Liu ZC, Luo XP, Li JY, Yu XM, Huang XZ, He Y, Xu TY, Xu JJ, Peng SC, Song YX, He Y, Zhuang XW, Zheng CC, Zhang F, Lam AK, Dai W, He ML, Liu B, Zhao Q, Lu GL, Liu JB, Wang ZN, Li ZG, Liu ZX, Xu WW, Li B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03223
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03223
Newcastle disease virus induces degradation of folliculin to regulate host cell energy metabolism and facilitate viral replication.
Yang M, Kan X, Li X, Sun Y, Liao Y, Qiu X, Tan L, Song C, Ding C
Poultry science 2025 Aug;104(8):105314
Poultry science 2025 Aug;104(8):105314
AR to GR switch modulates differential TDO2-Kyn-AhR signalling to promote the survival and recurrence of treatment-induced dormant cells in prostate cancer.
Li S, Zhang Y, Luo M, Zhou W, Chen Y, Wu D, Wei Q, Chang Y, Hu H
Cell discovery 2025 Aug 5;11(1):67
Cell discovery 2025 Aug 5;11(1):67
Bufalin inhibits hepatocellular carcinoma progression by blocking EGFR-mediated RAS-RAF-MEK-ERK pathway activation.
Liu J, Jiang J, Huang J, Fang ZE, Liu L, Liu Y, Nian W, Tang J, Wang Z
Journal of experimental & clinical cancer research : CR 2025 Aug 29;44(1):260
Journal of experimental & clinical cancer research : CR 2025 Aug 29;44(1):260
Piezo1 promotes colitis progression by modulating the Nrf2/NF-κB/NLRP3 signaling pathway.
Zhou P, Zeng L, Ma K, Li B, Zhang Y, Zhong Z, Wan Y, Tao K, Zhang P
Biochemical pharmacology 2025 Aug 29;242(Pt 1):117293
Biochemical pharmacology 2025 Aug 29;242(Pt 1):117293
Circulatory extracellular vesicles transport complement C1q for promoting neuronal amyloid-β production in Alzheimer's disease.
Yu Y, Xiao W, Ma Z, Yi X, Zhong T, Li Z
Journal of neuroinflammation 2025 Aug 29;22(1):209
Journal of neuroinflammation 2025 Aug 29;22(1):209
Curcumin analog C1 activates autophagy through a TFEB-dependent mechanism to protect sensory hair cells from oxidative stress in C57BL/6 mice with age-related hearing loss.
He W, Wu F, Liu W, Feng Y, Huang Y, Guo J, Lin X, Si Y, Zhang Z
International immunopharmacology 2025 Aug 28;161:115081
International immunopharmacology 2025 Aug 28;161:115081
NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer.
Zhao S, Lin J, Zhu B, Jin Y, Dong Q, Ruan X, Jin D, Yi Y, Bai B, Li H, Liang D, Lu J, Meng L, Wang X, Cui Y, Gu Y, Shen X, Lu X, Rao S, Sun W
eLife 2025 Aug 27;13
eLife 2025 Aug 27;13
Liver regeneration-associated hepatocellular YAP1 activation prevents colorectal cancer liver metastasis through glutamine competition.
Yu Q, Yu M, Xie P, Guo L, Zhao Y, Xu W, Li X, Wu M, Zhang Z, Chen Z, Xiao Y, Zhou J, Fan J, Hung MC, Xu Y, Zhang B, Ye Q, Li H
Science advances 2025 Aug 22;11(34):eadw6926
Science advances 2025 Aug 22;11(34):eadw6926
Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline.
Rajesh A, Havas AP, Arnold R, Lande K, Evensen KG, Li KY, Mamde S, Yang Q, Gandhi A, Miller KN, Teneche MG, Yao Z, Proulx J, Davis A, Haddadin L, Alcaraz M, Macip CC, Li B, Lei X, Miciano C, Smoot E, Wang A, Albrecht JH, Williams AE, Ren B, Yip KY, Adams PD
bioRxiv : the preprint server for biology 2025 Aug 2;
bioRxiv : the preprint server for biology 2025 Aug 2;
SIRT1 and its SUMOylation attenuate hyperoxia-induced lung injury by improving mitochondrial biogenesis and fusion.
Yang K, Zheng Q, Luo M, Zhang R, Zhao S, Kang L, Lei X, Dong W
Free radical biology & medicine 2025 Aug 16;236:98-115
Free radical biology & medicine 2025 Aug 16;236:98-115
PDE4D Regulates Mitochondrial Homeostasis and Adult Hippocampal Neurogenesis via the cAMP/CREB Signaling Pathway in Chronic Stress-Induced Depressive-Like Behavior.
Zhao W, Wang Z, Chen X, Zhao S, Zong F, Zhang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 15;39(15):e70882
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 15;39(15):e70882
UBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice.
Yu X, Cen J, Zhang Y, Li T, Zhang M, Gao F, Liu H, Cao Y
iScience 2025 Aug 15;28(8):112878
iScience 2025 Aug 15;28(8):112878
LncRNA EP300-AS1 interacts with PTBP1 to destabilize PRMT5 mRNA and suppresses NSCLC growth and metastasis.
Chen J, Fan C, Song S, Zhang D
Cell death & disease 2025 Aug 11;16(1):607
Cell death & disease 2025 Aug 11;16(1):607
VPS45 Contributes to the Progression of Hepatocellular Carcinoma by Triggering the Wnt/β-Catenin Signaling Pathway.
Zhi R, Li Q, Zhang H, Fan F
Molecular carcinogenesis 2025 Apr;64(4):744-755
Molecular carcinogenesis 2025 Apr;64(4):744-755
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768
Molecular neurobiology 2025 Apr;62(4):4743-4768
Subcellular proteomics reveals the crosstalk between nucleocytoplasmic trafficking and the innate immune response to Senecavirus A infection.
Li M, Deng X, Zhou M, Wan H, Shi Y, Zhang L, He W, Zhang Y, Hu M, Du Y, Jiang D, Han S, Wan B, Zhang G
International journal of biological macromolecules 2025 Apr;298:139898
International journal of biological macromolecules 2025 Apr;298:139898
Nrf2 alleviates acute ischemic stroke induced ferroptosis via regulating xCT/GPX4 pathway.
Ye Y, Xie X, Bi Y, Liu Q, Qiu L, Zhao H, Wang C, Zhu W, Zeng T
Free radical biology & medicine 2025 Apr;231:153-162
Free radical biology & medicine 2025 Apr;231:153-162
Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics.
Jiang S, Nong T, Yu T, Qin Z, Huang J, Yin Z, Luo S, Lai Y, Jin J
Environment international 2025 Apr;198:109390
Environment international 2025 Apr;198:109390
Yinaoxin granule alleviates cerebral ischemia-reperfusion injury by ferroptosis inhibition through Nrf2 pathway activation.
Weng J, Liu L, Li S, Yang Y, Zhou R, Zhang Z, Liu Y, Chen L, Feng Z, Tang Z, Xu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156476
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156476
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases.
Mu W, Xu G, Li L, Wen J, Xiu Y, Zhao J, Liu T, Wei Z, Luo W, Yang H, Wu Z, Zhan X, Xiao X, Bai Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2417686
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2417686
Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non-Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production.
Zeng QG, Li L, Chang T, Sun Y, Zheng B, Xue LN, Liu CL, Li XQ, Huang RT, Gu JX, An ZR, Yao HT, Zhou DY, Fan J, Dai Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411503
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411503
Tanshinone IIA Ameliorates Myocardial Ischemia-Reperfusion Injury via Activating HDAC1-Repressed Nrf2-xCT/Gpx4/HO-1 Axis.
Yan K, Yu S, Gao X, Li L, Ding L
Chemical biology & drug design 2025 Apr;105(4):e70095
Chemical biology & drug design 2025 Apr;105(4):e70095
The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses.
Sun H, Yang J, Zhang Z, Wu M, Tian Z, Liu Y, Zhang X, Zhong J, Yang S, Chen Y, Luo J, Guan G, Yin H, Niu Q
mBio 2025 Apr 9;16(4):e0267724
mBio 2025 Apr 9;16(4):e0267724
Endothelial USP11 drives VEGFR2 signaling and angiogenesis via PRDX2/c-MYC axis.
Chen C, Chen Z, Luo R, Tu W, Long M, Liang M, Cheng M, Wang Z, Huang K, Wang C
Angiogenesis 2025 Apr 8;28(2):23
Angiogenesis 2025 Apr 8;28(2):23
Structural optimization and characterization of highly potent and selective STAT3 inhibitors for the treatment of triple negative breast cancer.
Jin W, Zhang Y, Wang B, Kang Z, Li H, Song J, Chen Y, Xiong H, Chen J
European journal of medicinal chemistry 2025 Apr 5;287:117332
European journal of medicinal chemistry 2025 Apr 5;287:117332
HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages.
Woods PS, Cetin-Atalay R, Meliton AY, Sun KA, Shamaa OR, Shin KWD, Tian Y, Haugen B, Hamanaka RB, Mutlu GM
Scientific reports 2025 Apr 4;15(1):11574
Scientific reports 2025 Apr 4;15(1):11574
PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth.
He X, Chen D, Liu G, Wu Q, Zhao H, Guo D, Jiang X, Li M, Meng Y, Yin Y, Ye X, Luo S, Xia Y, Hunter T, Lu Z
Molecular cell 2025 Apr 3;85(7):1411-1425.e8
Molecular cell 2025 Apr 3;85(7):1411-1425.e8
A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide.
Wang Z, Ojogun N, Liu Y, Gan L, Xiao Z, Feng J, Jiang W, Chen Y, Zou B, Yu C, Li C, Ashuo A, Li X, Fu M, Wu J, Chu Y, Munford RS, Lu M
eLife 2025 Apr 24;13
eLife 2025 Apr 24;13
Tricetin, a Dietary Flavonoid, Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the PI3K/Akt/mTOR Signaling Pathway.
Wu X, Su D, Xu J, Ge G, Zhang Y, Wu B, Hu K, Ren J, Yang H
Journal of agricultural and food chemistry 2025 Apr 23;73(16):9677-9689
Journal of agricultural and food chemistry 2025 Apr 23;73(16):9677-9689
MiR•101 and miR•122 Targeting δ-Catenin to Regulate Keratinocyte Responsiveness to IL-17A in Psoriasis.
Shen Y, Zhou Y, Chiwa KA, Wang J, Ren S, Wang M, Ren H, Zheng Y, Yu Y, Jiang L, Yu J, Qiao Y, Jin L, Lou J, Zheng X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70539
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70539
The ZBTB24-CDCA7-HELLS axis suppresses the totipotent 2C-like reprogramming by maintaining Dux methylation and repression.
Guo D, Du Z, Liu Y, Lin M, Lu Y, Hardikar S, Xue Y, Zhang J, Chen T, Dan J
Nucleic acids research 2025 Apr 10;53(7)
Nucleic acids research 2025 Apr 10;53(7)
Aquaporin 9 downregulation in KRAS(G12V) colorectal cancer and associated with increased proliferation and decreased apoptosis in cancer cells.
Liu Y, Dou J, Tan Q, Chen S, Li Y, Wang R, Sun N, Qi X
Scientific reports 2025 Apr 10;15(1):12298
Scientific reports 2025 Apr 10;15(1):12298
A novel TLR4 accessory molecule drives hepatic oncogenesis through tumor-associated macrophages.
Kim D, Allen CA, Chung D, Meng L, Zhang X, Zhang W, Ouyang Y, Li Z, Hong F
Cancer letters 2025 Apr 1;614:217543
Cancer letters 2025 Apr 1;614:217543
Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity.
Sawyer AM, Vaca CC, Malik N, Clerc I, Craft J, Hudson H, Scholtés GK, Schiltz GE, Roh M, Song C, D'Aquila RT
Viruses 2025 Apr 1;17(4)
Viruses 2025 Apr 1;17(4)
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Lu J, Su P, Zhao F, Yu K, Yang X, Lv H, Wang D, Zhang J
Current research in toxicology 2024;7:100193
Current research in toxicology 2024;7:100193
Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis.
Proper SP, Dwyer AT, Appiagyei A, Felton JM, Ben-Baruch Morgenstern N, Marlman JM, Kotliar M, Barski A, Troutman TD, Rothenberg ME, Mersha TB, Azouz NP
Frontiers in allergy 2024;5:1323405
Frontiers in allergy 2024;5:1323405
Berberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice.
Jiang C, Lao G, Ran J, Zhu P
Experimental biology and medicine (Maywood, N.J.) 2024;249:10280
Experimental biology and medicine (Maywood, N.J.) 2024;249:10280
HMGB1 Modulates High Glucose-Induced Erroneous Differentiation of Tendon Stem/Progenitor Cells through RAGE/β-Catenin Pathway.
Lu P, Dai G, Shi L, Li Y, Zhang M, Wang H, Rui Y
Stem cells international 2024;2024:2335270
Stem cells international 2024;2024:2335270
SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.
Wu J, Huang M, Dong W, Chen Y, Zhou Q, Zhang Q, Zheng J, Liu Y, Zhang Y, Liu S, Yang C, Chen S, Huang J, Lin T, Chen X
International journal of biological sciences 2024;20(10):3986-4006
International journal of biological sciences 2024;20(10):3986-4006
CAPE activates AMPK and Foxo3 signaling to induce growth inhibition and ferroptosis in triple-negative breast cancer.
Fang Q, Fang Q, Cheng R, Feng T, Xin W
PloS one 2024;19(12):e0315037
PloS one 2024;19(12):e0315037
The Therapeutic Potential of Pristimerin in Osteoarthritis: Mechanistic Insights from in vitro and in vivo Studies.
Yin L, Fan Y, Zhong X, Meng X, He Z, Hong Z, Chen J, Zhang Q, Kong M, Wang J, Tong Y, Bi Q
Drug design, development and therapy 2024;18:5445-5459
Drug design, development and therapy 2024;18:5445-5459
Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis.
Cui Y, Liu Q, Zhang Q, Di X, Zhang H
Drug design, development and therapy 2024;18:2125-2142
Drug design, development and therapy 2024;18:2125-2142
Elucidating the role of 4-hydroxy-2(3H)-benzoxazolone in chronic alcoholic liver disease via transcriptomics and metabolomics.
Lu JF, Xing SP, Wei X, Yang CX, Zhao GS, Ma XL, Sun XM, Guo HW, Su ZH, Fang B, Lin J, Liu YY, Zhu D
Frontiers in pharmacology 2024;15:1447560
Frontiers in pharmacology 2024;15:1447560
Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes.
Feng S, Liu L, Cheng Y, Zhou M, Zhu H, Zhao X, Chen Z, Kan S, Fu X, Hu W, Zhu R
Frontiers in pharmacology 2024;15:1434652
Frontiers in pharmacology 2024;15:1434652
PFKFB3 deprivation attenuates the cisplatin resistance via blocking its autophagic elimination in colorectal cancer cells.
Li Q, Ma J, Zhang Y, Sun F, Li W, Shen W, Ai Z, Li C, Wang S, Wei X, Yan S
Frontiers in pharmacology 2024;15:1433137
Frontiers in pharmacology 2024;15:1433137
Bergamottin (Ber) ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway.
Shen G, Zhang W, Tu Q, Wang J
Frontiers in pharmacology 2024;15:1389786
Frontiers in pharmacology 2024;15:1389786
Anti-inflammatory and uric acid lowering effects of Euodiae fructus on hyperuricemia and gout mice.
Wang Z, Liu J, Mou Y, Liao W, Li Y, Liu J, Tang J
Frontiers in pharmacology 2024;15:1296075
Frontiers in pharmacology 2024;15:1296075
Deciphering m(6)A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy.
Li J, Wei L, Hu K, He Y, Gong G, Liu Q, Zhang Y, Zhou K, Guo J, Hua Y, Tang J, Li Y
Theranostics 2024;14(9):3486-3508
Theranostics 2024;14(9):3486-3508
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway.
Li L, Lu L, Xiao Z, Lv J, Huang H, Wu B, Zhao T, Li C, Wang W, Wang H
Science China. Life sciences 2024 Sep;67(9):1915-1927
Science China. Life sciences 2024 Sep;67(9):1915-1927
The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice.
Li XM, Li HD, Shao YY, Ji JZ, Tang K, Zheng ZD, Wu Y, Ding PJ, Wang J, Jiang LP, Tai T, Mi QY, Fu M, Xie HG
Xenobiotica; the fate of foreign compounds in biological systems 2024 Sep;54(9):759-769
Xenobiotica; the fate of foreign compounds in biological systems 2024 Sep;54(9):759-769
Intervention of Asprosin Attenuates Oxidative Stress and Neointima Formation in Vascular Injury.
Zheng F, Ye C, Lei JZ, Ge R, Li N, Bo JH, Chen AD, Zhang F, Zhou H, Wang JJ, Chen Q, Li YH, Zhu GQ, Han Y
Antioxidants & redox signaling 2024 Sep;41(7-9):488-504
Antioxidants & redox signaling 2024 Sep;41(7-9):488-504
Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway.
Huang J, Hu X, Li J, Gong D
Naunyn-Schmiedeberg's archives of pharmacology 2024 Sep;397(9):6647-6659
Naunyn-Schmiedeberg's archives of pharmacology 2024 Sep;397(9):6647-6659
Usutu virus NS4A suppresses the host interferon response by disrupting MAVS signaling.
Nelemans T, Tas A, Kikkert M, van Hemert MJ
Virus research 2024 Sep;347:199431
Virus research 2024 Sep;347:199431
The I7L protein of African swine fever virus is involved in viral pathogenicity by antagonizing the IFN-γ-triggered JAK-STAT signaling pathway through inhibiting the phosphorylation of STAT1.
Li M, Liu X, Peng D, Yao M, Wang T, Wang Y, Cao H, Wang Y, Dai J, Luo R, Deng H, Li J, Luo Y, Li Y, Sun Y, Li S, Qiu HJ, Li LF
PLoS pathogens 2024 Sep;20(9):e1012576
PLoS pathogens 2024 Sep;20(9):e1012576
Polystyrene nanoparticles trigger aberrant condensation of TDP-43 and amyotrophic lateral sclerosis-like symptoms.
Sun H, Yang B, Li Q, Zhu X, Song E, Liu C, Song Y, Jiang G
Nature nanotechnology 2024 Sep;19(9):1354-1365
Nature nanotechnology 2024 Sep;19(9):1354-1365
Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L.
Li Y, Xiao P, Sun Y, Li Y, Zhao H, Sun J, Wang X, Han X, Jin N, Li X, Bao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117215
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117215
Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by γ-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells.
Mori M, Ii H, Fujita M, Nose K, Shimada A, Shiraki R, Sone Y, Moyama C, Taniguchi K, Nakata S
Cancer genomics & proteomics 2024 Sep-Oct;21(5):474-484
Cancer genomics & proteomics 2024 Sep-Oct;21(5):474-484
USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling.
Ma M, Yi L, Pei Y, Zhang Q, Tong C, Zhao M, Chen Y, Zhu J, Zhang W, Yao F, Yang P, Zhang P
Nature communications 2024 Sep 9;15(1):7856
Nature communications 2024 Sep 9;15(1):7856
FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes.
Ma A, Yang Y, Cao L, Chen L, Zhang JV
Communications biology 2024 Sep 7;7(1):1099
Communications biology 2024 Sep 7;7(1):1099
Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents.
Villagomez FR, Lang J, Nunez-Avellaneda D, Behbakht K, Dimmick HL, Webb P, Nephew KP, Neville M, Woodruff ER, Bitler BG
bioRxiv : the preprint server for biology 2024 Sep 7;
bioRxiv : the preprint server for biology 2024 Sep 7;
YIPF2 regulates genome integrity.
Zhang X, Wang T
Cell & bioscience 2024 Sep 5;14(1):114
Cell & bioscience 2024 Sep 5;14(1):114
Anoectochilus roxburghii polysaccharide reduces D-GalN/LPS-induced acute liver injury by regulating the activation of multiple inflammasomes.
Yan Y, Ye X, Huang C, Wu J, Liu Y, Zheng P, Shen C, Bai Z, Tingming S
The Journal of pharmacy and pharmacology 2024 Sep 3;76(9):1212-1224
The Journal of pharmacy and pharmacology 2024 Sep 3;76(9):1212-1224
Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis.
Miao W, Hu YZ
Journal of geriatric cardiology : JGC 2024 Sep 28;21(9):899-912
Journal of geriatric cardiology : JGC 2024 Sep 28;21(9):899-912
Unveiling the anticancer potential of plumbagin: targeting pyruvate kinase M2 to induce oxidative stress and apoptosis in hepatoma cells.
Wu J, Ding Z, Tu J, Osama A, Nie Q, Cai W, Zhang B
RSC medicinal chemistry 2024 Sep 20;15(12):4126-37
RSC medicinal chemistry 2024 Sep 20;15(12):4126-37
Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton.
Zhang Y, Kang HR, Jun Y, Kang H, Bang G, Ma R, Ju S, Yoon DE, Kim Y, Kim K, Kim JY, Han K
Human molecular genetics 2024 Sep 19;33(19):1671-1687
Human molecular genetics 2024 Sep 19;33(19):1671-1687
VP3 protein of Senecavirus A promotes viral IRES-driven translation and attenuates innate immunity by specifically relocalizing hnRNPA2B1.
Li L, Li X, Zhong H, Li M, Wan B, He W, Zhang Y, Du Y, Chen D, Zhang W, Ji P, Jiang D, Han S
Journal of virology 2024 Sep 17;98(9):e0122724
Journal of virology 2024 Sep 17;98(9):e0122724
Alkaloids of Aconiti Lateralis Radix Praeparata inhibit growth of non-small cell lung cancer by regulating PI3K/Akt-mTOR signaling and glycolysis.
Zhang W, Cai S, Qin L, Feng Y, Ding M, Luo Z, Shan J, Di L
Communications biology 2024 Sep 11;7(1):1118
Communications biology 2024 Sep 11;7(1):1118
Tryptanthrin targets GSTP1 to induce senescence and increases the susceptibility to apoptosis by senolytics in liver cancer cells.
Zhang Y, Xiao B, Yuan S, Ding L, Pan Y, Jiang Y, Sun S, Ke X, Cai L, Jia L
Redox biology 2024 Oct;76:103323
Redox biology 2024 Oct;76:103323
Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H(2)O(2)-Induced Neuronal PC12 Cells and Prolongs the Lifespan of Caenorhabditis elegans.
Wu S, Miao J, Zhu S, Wu X, Shi J, Zhou J, Xing Y, Hu K, Ren J, Yang H
Molecular neurobiology 2024 Oct;61(10):8219-8233
Molecular neurobiology 2024 Oct;61(10):8219-8233
Calcipotriol abrogates TGF-β1/pSmad3-mediated collagen 1 synthesis in pancreatic stellate cells by downregulating RUNX1.
Zheng M, Li H, Sun L, Cui S, Zhang W, Gao Y, Gao R
Toxicology and applied pharmacology 2024 Oct;491:117078
Toxicology and applied pharmacology 2024 Oct;491:117078
The impact of NUMB on chicken abdominal adipogenesis: A comprehensive analysis.
Wang Z, Zhao M, Su Y, Zhao Q, Ma Z, Yue Q, Zhu Z, Zhang L, Hou Z, Li H
International journal of biological macromolecules 2024 Oct;278(Pt 3):134904
International journal of biological macromolecules 2024 Oct;278(Pt 3):134904
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise.
Park SJ, Son SM, Barbosa AD, Wrobel L, Stamatakou E, Squitieri F, Balmus G, Rubinsztein DC
Nature cell biology 2024 Oct;26(10):1691-1699
Nature cell biology 2024 Oct;26(10):1691-1699
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
Pan F, Yang W, Zhao T, Liu K, Zhao S, Zhao L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
Protein inhibitor of activated signal transducer and activator of transcription 2 is an oncoprotein in oral squamous cell carcinoma and related to cigarette smoking - An in vitro study.
Chen SY, Chiang CF, Su YF, Lin CY, Hung YJ, Huang TW, Shieh YS
Journal of dental sciences 2024 Oct;19(4):1983-1990
Journal of dental sciences 2024 Oct;19(4):1983-1990
Low-dose radiation promotes high-fat diet-induced atherosclerosis by activating cGAS signal pathway.
Liu X, Huang X, Luo J, Gao SN, Bai C, Xie D, Gao SS, Guan H, Huang R, Zhou PK
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167443
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167443
Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer.
Lu Q, Ren N, Chen H, Zhang S, Yan R, Li M, Zheng L, Tan W, Lin D
Frontiers of medicine 2024 Oct;18(5):921-937
Frontiers of medicine 2024 Oct;18(5):921-937
Targeting SNAI1-Mediated Colorectal Cancer Chemoresistance and Stemness by Sphingosine Kinase 2 Inhibition.
Janakiraman H, Gao Z, Zhu Y, Dong J, Becker SA, Janneh A, Ogretmen B, Camp ER
World journal of oncology 2024 Oct;15(5):744-757
World journal of oncology 2024 Oct;15(5):744-757
Oleanolic acid attenuates obesity through modulating the lipid metabolism in high-fat diet-fed mice.
Zhang G, Zhang H, Dong R, Zhao H, Li J, Yue W, Ma Z
Food science & nutrition 2024 Oct;12(10):8243-8254
Food science & nutrition 2024 Oct;12(10):8243-8254
Orientin promotes diabetic wounds healing by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
Yang JY, Zhuang C, Lin YZ, Yu YT, Zhou CC, Zhang CY, Zhu ZT, Qian CJ, Zhou YN, Zheng WH, Zhao Y, Jin C, Wu ZY
Food science & nutrition 2024 Oct;12(10):7461-7480
Food science & nutrition 2024 Oct;12(10):7461-7480
The syntaxin-binding protein STXBP5 regulates progerin expression.
Qi H, Wu Y, Zhang W, Yu N, Lu X, Liu J
Scientific reports 2024 Oct 8;14(1):23376
Scientific reports 2024 Oct 8;14(1):23376
Tumor cell-intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance.
Miao N, Cao D, Jin J, Ma G, Yu H, Qu J, Li G, Gao C, Dong D, Xia F, Li W
The Journal of experimental medicine 2024 Oct 7;221(10)
The Journal of experimental medicine 2024 Oct 7;221(10)
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
Zhang H, Xiao X, Wang L, Shi X, Fu N, Wang S, Zhao RC
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
LAP2alpha facilitates myogenic gene expression by preventing nucleoplasmic lamin A/C from spreading to active chromatin regions.
Ferraioli S, Sarigol F, Prakash C, Filipczak D, Foisner R, Naetar N
Nucleic acids research 2024 Oct 28;52(19):11500-11518
Nucleic acids research 2024 Oct 28;52(19):11500-11518
Myrislignan ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Wang L, Fu X, Xia T, Yang Z, Zhao R
International immunopharmacology 2024 Oct 25;140:112887
International immunopharmacology 2024 Oct 25;140:112887
CRISPR associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons resulting in KRAB-specific degradation.
Cajka G, Liu M, Shalem O
bioRxiv : the preprint server for biology 2024 Oct 19;
bioRxiv : the preprint server for biology 2024 Oct 19;
Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin.
Filipczak D, Souchet A, Georgiou K, Foisner R, Naetar N
iScience 2024 Oct 18;27(10):110869
iScience 2024 Oct 18;27(10):110869
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance.
Engel JL, Zhang X, Wu M, Wang Y, Espejo Valle-Inclán J, Hu Q, Woldehawariat KS, Sanders MA, Smogorzewska A, Chen J, Cortés-Ciriano I, Lo RS, Ly P
Cell 2024 Oct 17;187(21):6055-6070.e22
Cell 2024 Oct 17;187(21):6055-6070.e22
HIF-1α regulates mitochondrial function in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages.
Woods PS, Cetin-Atalay R, Meliton AY, Sun KA, Shamaa OR, Shin KWD, Tian Y, Haugen B, Hamanaka RB, Mutlu GM
bioRxiv : the preprint server for biology 2024 Oct 14;
bioRxiv : the preprint server for biology 2024 Oct 14;
Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling.
Zhu XX, Meng XY, Chen G, Su JB, Fu X, Xu AJ, Liu Y, Hou XH, Qiu HB, Sun QY, Hu JY, Lv ZL, Sun HJ, Jiang HB, Han ZJ, Zhu J, Lu QB
Cell communication and signaling : CCS 2024 Oct 11;22(1):488
Cell communication and signaling : CCS 2024 Oct 11;22(1):488
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice.
Zhang Y, Zhang C, Dai Q, Ma R
Neuromolecular medicine 2024 Oct 10;26(1):40
Neuromolecular medicine 2024 Oct 10;26(1):40
TRIM33 promotes glycolysis through regulating P53 K48-linked ubiquitination to promote esophageal squamous cell carcinoma growth.
Xia T, Meng L, Xu G, Sun H, Chen H
Cell death & disease 2024 Oct 10;15(10):740
Cell death & disease 2024 Oct 10;15(10):740
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders.
Luo JH, Wang FX, Zhao JW, Yang CL, Rong SJ, Lu WY, Chen QJ, Zhou Q, Xiao J, Wang YN, Luo X, Li Y, Song DN, Chen C, Zhang CL, Chen SH, Yang P, Xiong F, Yu QL, Zhang S, Liu SW, Sun F, Wang CY
Cell metabolism 2024 Oct 1;36(10):2262-2280.e5
Cell metabolism 2024 Oct 1;36(10):2262-2280.e5
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
Liu C, Wu C, Zhang S, Lv Z
Experimental gerontology 2024 Oct 1;195:112528
Experimental gerontology 2024 Oct 1;195:112528
Downregulation of short-stature homeobox protein 2 suppresses gastric cancer cell growth and stemness in vitro and in vivo via inactivating wnt/β-catenin signaling.
Chen X, Li S, Sun B
Drug development research 2024 Nov;85(7):e70006
Drug development research 2024 Nov;85(7):e70006
Combined treatment with Aronia berry extract and oligomeric proanthocyanidins exhibit a synergistic anticancer efficacy through LMNB1-AKT signaling pathways in colorectal cancer.
Li Y, Xu C, Weng W, Goel A
Molecular carcinogenesis 2024 Nov;63(11):2145-2157
Molecular carcinogenesis 2024 Nov;63(11):2145-2157
Sappanone A ameliorates acute lung injury through inhibiting the activation of the NF-κB signaling pathway.
Du J, Zhou P, Zhao X, He YT, He CS, Wang RY
Toxicology and applied pharmacology 2024 Nov;492:117127
Toxicology and applied pharmacology 2024 Nov;492:117127
CypA/TAF15/STAT5A/miR-514a-3p feedback loop drives ovarian cancer metastasis.
Li Y, Yang H, Li A, Chen B, Wang Y, Song Z, Tan H, Li H, Feng Q, Zhou Y, Li S, Zeng L, Lan T
Oncogene 2024 Nov;43(49):3570-3585
Oncogene 2024 Nov;43(49):3570-3585
Ginkgo Flavone Aglycone Ameliorates Atherosclerosis via Inhibiting Endothelial Pyroptosis by Activating the Nrf2 Pathway.
Chen X, Yang Z, Liao M, Zhao Q, Lu Y, Li Q, Liu S, Li S, Chen J, He Y
Phytotherapy research : PTR 2024 Nov;38(11):5458-5473
Phytotherapy research : PTR 2024 Nov;38(11):5458-5473
Metformin attenuates PM(2.5)-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells.
Cui J, Chen W, Zhang D, Lu M, Huang Z, Yi B
Toxicology mechanisms and methods 2024 Nov;34(9):1022-1034
Toxicology mechanisms and methods 2024 Nov;34(9):1022-1034
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
SIRT2 regulates high mobility group protein B1 nucleoplasmic shuttle and degradation via deacetylation in microglia.
Xing WQ, Piao XJ, Han Q, Shi HY, Wu WC, Si F, Lu JJ, Zhou TZ, Guo JR, Li SZ, Xu B
Journal of cellular physiology 2024 Nov;239(11):e31364
Journal of cellular physiology 2024 Nov;239(11):e31364
Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.
Dai Y, Chen J, Fang J, Liang S, Zhang H, Li H, Chen W
Biochemical pharmacology 2024 Nov;229:116518
Biochemical pharmacology 2024 Nov;229:116518
Bipartite nuclear localization sequence is indispensable for nuclear import and stability of self-dimerization of ADARa in Bombyx mori.
Jiang S, Peng J, Saneela S, Shi R, Wang D, Tang Q, Shi X, Meng Y
Insect biochemistry and molecular biology 2024 Nov;174:104190
Insect biochemistry and molecular biology 2024 Nov;174:104190
Eupafolin hinders cross-talk between gastric cancer cells and cancer-associated fibroblasts by abrogating the IL18/IL18RAP signaling axis.
Yan H, Wang P, Zhou Q, Dong X, Wang Q, Yuan Z, Zhai B, Zhou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155984
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155984
TMEM232 is required for the formation of sperm flagellum and male fertility in mice.
Cai X, Zhang H, Kong S, Xu W, Zheng J, Wang N, He S, Li S, Shen Y, Wang K, Zhang Z, Cai H, Ma F, Bai S, Zhu F, Xiao F, Wang F
Cell death & disease 2024 Nov 8;15(11):806
Cell death & disease 2024 Nov 8;15(11):806
ML385 promotes ferroptosis and radiotherapy sensitivity by inhibiting the NRF2-SLC7A11 pathway in esophageal squamous cell carcinoma.
Yan L, Hu H, Feng L, Li Z, Zheng C, Zhang J, Yin X, Li B
Medical oncology (Northwood, London, England) 2024 Nov 7;41(12):309
Medical oncology (Northwood, London, England) 2024 Nov 7;41(12):309
LncRNA DDX11-AS1 promotes breast cancer progression by targeting the miR-30c-5p/MTDH axis.
Li Y, Zhou M, Yang L, Liu S, Yang L, Xu B, Li X, Zhao H, Song Z
Scientific reports 2024 Nov 5;14(1):26745
Scientific reports 2024 Nov 5;14(1):26745
BAP1 inactivation promotes lactate production by leveraging the subcellular localization of LDHA in melanoma.
Zheng G, Shi J, Li Q, Jin X, Fang Y, Zhang Z, Cao Q, Zhu L, Shen J
Cell death discovery 2024 Nov 26;10(1):483
Cell death discovery 2024 Nov 26;10(1):483
Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ.
Zhao HY, Zhu YP, Wen Y, Sun J, Ding XY, Cao XY, Wu KL, Fu L, Li LY
Biological research 2024 Nov 24;57(1):90
Biological research 2024 Nov 24;57(1):90
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.
Mikhova M, Goff NJ, Janovič T, Heyza JR, Meek K, Schmidt JC
Nature communications 2024 Nov 23;15(1):10159
Nature communications 2024 Nov 23;15(1):10159
P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker.
Yuan Z, Jing H, Deng Y, Liu M, Jiang T, Jin X, Lin W, Liu Y, Yin J
Oncogenesis 2024 Nov 23;13(1):42
Oncogenesis 2024 Nov 23;13(1):42
Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema.
Simborio H, Hayek H, Kosmider B, Elrod JW, Bolla S, Marchetti N, Criner GJ, Bahmed K
Cell communication and signaling : CCS 2024 Nov 22;22(1):562
Cell communication and signaling : CCS 2024 Nov 22;22(1):562
METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.
Bai X, Liu J, Zhou S, Wu L, Feng X, Zhang P
Journal of experimental & clinical cancer research : CR 2024 Nov 20;43(1):307
Journal of experimental & clinical cancer research : CR 2024 Nov 20;43(1):307
Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2/GPX4 axis.
Bian W, Wei L, Wang K
International immunopharmacology 2024 Nov 15;141:113020
International immunopharmacology 2024 Nov 15;141:113020
Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways.
Ma J, Wang Z, Sun Y, Zheng R, Tan H, Zhang H, Jin Z, Wu Y, Sun Z
International immunopharmacology 2024 Nov 15;141:112960
International immunopharmacology 2024 Nov 15;141:112960
The deleterious effects of CDK4/6 inhibition on renal recovery post-acute kidney injury.
Zhou S, Peng R, Shen Y, Huang L, Han S, Wang J, Guo J
Scientific reports 2024 Nov 15;14(1):28143
Scientific reports 2024 Nov 15;14(1):28143
Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis.
Chen L, Chen D, Pan Y, Mo Y, Lai B, Chen H, Zhang DW, Xia XD
Cell death & disease 2024 Nov 1;15(11):786
Cell death & disease 2024 Nov 1;15(11):786
ER-tethered RNA-binding protein controls NADPH oxidase translation for hydrogen peroxide homeostasis.
Pei X, Wang Z, He W, Li S, Chen X, Fan Z, Lan Y, Yuan L, Xu P
Redox biology 2024 May;71:103126
Redox biology 2024 May;71:103126
OTUD6A orchestrates complex modulation of TEAD4-mediated transcriptional programs.
Kim HJ, Choi Y, Lee Y, Hwangbo M, Kim J
FEBS letters 2024 May;598(9):1045-1060
FEBS letters 2024 May;598(9):1045-1060
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3.
Cheng S, Chen L, Ying J, Wang Y, Jiang W, Zhang Q, Zhang H, Wang J, Wang C, Wu H, Ye J, Zhang L
Journal of ginseng research 2024 May;48(3):298-309
Journal of ginseng research 2024 May;48(3):298-309
Polyene phosphatidylcholine enhances the therapeutic response of oxaliplatin in gastric cancer through Nrf2/HMOX1 mediated ferroptosis.
Lei P, Cao L, Zhang H, Fu J, Wei X, Zhou F, Cheng J, Ming J, Lu H, Jiang T
Translational oncology 2024 May;43:101911
Translational oncology 2024 May;43:101911
Icariin ameliorates glycolytic dysfunction in Alzheimer's disease models by activating the Wnt/β-catenin signaling pathway.
Liu J, Wei AH, Liu TT, Ji XH, Zhang Y, Yan F, Chen MX, Hu JB, Zhou SY, Shi JS, Jin H, Jin F
The FEBS journal 2024 May;291(10):2221-2241
The FEBS journal 2024 May;291(10):2221-2241
SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia.
Sun W, Wang J, Liu C, Gao F, Ou Q, Tian H, Xu J, Zhang J, Li J, Xu J, Jia S, Zhang J, Xu G, Huang J, Jin C, Lu L
International journal of biological macromolecules 2024 May;268(Pt 2):131678
International journal of biological macromolecules 2024 May;268(Pt 2):131678
An integrated multi-omics analysis reveals osteokines involved in global regulation.
Liang W, Wei T, Hu L, Chen M, Tong L, Zhou W, Duan X, Zhao X, Zhou W, Jiang Q, Xiao G, Zou W, Chen D, Zou Z, Bai X
Cell metabolism 2024 May 7;36(5):1144-1163.e7
Cell metabolism 2024 May 7;36(5):1144-1163.e7
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Cell metabolism 2024 May 7;36(5):1059-1075.e9
SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress.
Jing S, Gao J, Tiwari N, Du Y, Zhu L, Gim B, Qian Y, Yue X, Lee I
Communications biology 2024 May 6;7(1):532
Communications biology 2024 May 6;7(1):532
p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol.
Wrobel L, Hoffmann JL, Li X, Rubinsztein DC
Science advances 2024 May 3;10(18):eadl6082
Science advances 2024 May 3;10(18):eadl6082
Heat stress upregulates arachidonic acid to trigger autophagy in sertoli cells via dysfunctional mitochondrial respiratory chain function.
Hu Y, Luo NJ, Gan L, Xue HY, Luo KY, Zhang JJ, Wang XZ
Journal of translational medicine 2024 May 26;22(1):501
Journal of translational medicine 2024 May 26;22(1):501
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.
Mikhova M, Goff NJ, Janovič T, Heyza JR, Meek K, Schmidt JC
bioRxiv : the preprint server for biology 2024 May 25;
bioRxiv : the preprint server for biology 2024 May 25;
Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm.
Wen Y, Liu Y, Li Q, Tan J, Fu X, Liang Y, Tuo Y, Liu L, Zhou X, LiuFu D, Fan X, Chen C, Chen Z, Wang Z, Fan S, Liu R, Pan L, Zhang Y, Tang WH
Circulation research 2024 May 24;134(11):1495-1511
Circulation research 2024 May 24;134(11):1495-1511
An integrated network pharmacology, molecular docking and experiment validation study to investigate the potential mechanism of Isobavachalcone in the treatment of osteoarthritis.
Fan Y, Yin L, Zhong X, He Z, Meng X, Chai F, Kong M, Zhang Q, Xia C, Tong Y, Bi Q
Journal of ethnopharmacology 2024 May 23;326:117827
Journal of ethnopharmacology 2024 May 23;326:117827
Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice.
Liang Y, Luo C, Sun L, Feng T, Yin W, Zhang Y, Mulholland MW, Zhang W, Yin Y
Nature communications 2024 May 23;15(1):4393
Nature communications 2024 May 23;15(1):4393
Dexamethasone-Integrated Mesenchymal Stem Cells for Systemic Lupus Erythematosus Treatment via Multiple Immunomodulatory Mechanisms.
Ma W, Che J, Chen W, Wang D, Zhang H, Zhao Y
ACS nano 2024 May 21;18(20):13249-13265
ACS nano 2024 May 21;18(20):13249-13265
Silent information regulator 2 deficiency exacerbates chronic cold exposure-induced colonic injury and p65 activation in mice.
Guo J, Zhang H, Hu H, Zhao T, Ji H, Ma L, Lu J, Yuan J, Xu B
Gene 2024 May 20;907:148276
Gene 2024 May 20;907:148276
Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging.
Haga M, Iida K, Okada M
iScience 2024 May 17;27(5):109708
iScience 2024 May 17;27(5):109708
The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.
Wu A, Zhong C, Song X, Yuan W, Tang M, Shu T, Huang H, Yang P, Liu Q
iScience 2024 May 17;27(5):109510
iScience 2024 May 17;27(5):109510
Tumor derived exosomal ENTPD2 impair CD8(+) T cell function in colon cancer through ATP-adenosine metabolism reprogramming.
Shi M, Ye L, Zhao L, He L, Chen J, Zhang J, Su Y, Dong H, Liu J, Liang L, Zheng W, Xiao Y, Liu H, Yang X, Yang Z
Cell communication and signaling : CCS 2024 May 16;22(1):274
Cell communication and signaling : CCS 2024 May 16;22(1):274
Metformin induction of heat shock factor 1 activation and the mitochondrial unfolded protein response alleviate cardiac remodeling in spontaneously hypertensive rats.
Xu M, Li LP, He X, Lu XZ, Bi XY, Li Q, Xue XR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23654
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 15;38(9):e23654
6PPDQ induces cardiomyocyte senescence via AhR/ROS-mediated autophagic flux blockage.
Fu B, Chen T, Jiang B, Feng H, Zhu Z, Li M, Zhang G, Jiang Y
Environmental pollution (Barking, Essex : 1987) 2024 May 15;349:123872
Environmental pollution (Barking, Essex : 1987) 2024 May 15;349:123872
25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages.
Xiao J, Wang S, Chen L, Ding X, Dang Y, Han M, Zheng Y, Shen H, Wu S, Wang M, Yang D, Li N, Dong C, Hu M, Su C, Li W, Hui L, Ye Y, Tang H, Wei B, Wang H
Immunity 2024 May 14;57(5):1087-1104.e7
Immunity 2024 May 14;57(5):1087-1104.e7
Nuclear AGO2 promotes myocardial remodeling by activating ANKRD1 transcription in failing hearts.
Xie R, Yuan S, Hu G, Zhan J, Jin K, Tang Y, Fan J, Zhao Y, Wang F, Chen C, Wang DW, Li H
Molecular therapy : the journal of the American Society of Gene Therapy 2024 May 1;32(5):1578-1594
Molecular therapy : the journal of the American Society of Gene Therapy 2024 May 1;32(5):1578-1594
Edaravone dexborneol protects against cerebral ischemia/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2/HO-1/GPX4 signaling.
Xiao P, Huang H, Zhao H, Liu R, Sun Z, Liu Y, Chen N, Zhang Z
Free radical biology & medicine 2024 May 1;217:116-125
Free radical biology & medicine 2024 May 1;217:116-125
M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes.
Hu Y, Jiang L, Wang G, Song Y, Shan Z, Wang X, Deng G, Shi J, Tian G, Zeng X, Liu L, Chen H, Li C
Science China. Life sciences 2024 Mar;67(3):579-595
Science China. Life sciences 2024 Mar;67(3):579-595
Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation.
Mao H, Feng Y, Feng J, Yusufu Y, Sun M, Yang L, Jiang Q
Journal of orthopaedic translation 2024 Mar;45:236-246
Journal of orthopaedic translation 2024 Mar;45:236-246
Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway.
Che J, Wang H, Dong J, Wu Y, Zhang H, Fu L, Zhang J
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
CNS neuroscience & therapeutics 2024 Mar;30(3):e14454
Circular RNA-circLRP6 protects cardiomyocyte from hypoxia-induced apoptosis by facilitating hnRNPM-mediated expression of FGF-9.
Ding W, Ding L, Lu Y, Sun W, Wang Y, Wang J, Gao Y, Li M
The FEBS journal 2024 Mar;291(6):1246-1263
The FEBS journal 2024 Mar;291(6):1246-1263
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
HuR-positive stress granules: Potential targets for age-related osteoporosis.
Huai Y, Wang X, Mao W, Wang X, Zhao Y, Chu X, Huang Q, Ru K, Zhang L, Li Y, Chen Z, Qian A
Aging cell 2024 Mar;23(3):e14053
Aging cell 2024 Mar;23(3):e14053
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
Miao L, Wang ST, Wei QH, Ma RF, Zhang H
Phytochemistry 2024 Mar;219:113984
Phytochemistry 2024 Mar;219:113984
Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
Shi W, Wang J, Li Z, Xu S, Wang J, Zhang L, Yang H
Free radical biology & medicine 2024 Mar;213:343-358
Free radical biology & medicine 2024 Mar;213:343-358
CDK12 inhibition upregulates ATG7 triggering autophagy via AKT/FOXO3 pathway and enhances anti-PD-1 efficacy in colorectal cancer.
Wu Z, Zhang W, Chen L, Wang T, Wang X, Shi H, Zhang L, Zhong M, Shi X, Mao X, Chen H, Li Q
Pharmacological research 2024 Mar;201:107097
Pharmacological research 2024 Mar;201:107097
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
Du J, Ji X, Xu B, Du Q, Li Y, Zhou B, Liu X, Xu Z, Jiang Y, Kou B, Li Z, Cui C, Lin J
Metabolism: clinical and experimental 2024 Mar;152:155769
Metabolism: clinical and experimental 2024 Mar;152:155769
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping.
Hao DJ, Qin Y, Zhou SJ, Dong BH, Yang JS, Zou P, Wang LP, Zhao YT
Journal of pharmaceutical analysis 2024 Mar;14(3):335-347
Journal of pharmaceutical analysis 2024 Mar;14(3):335-347
LuQi formula attenuates Cardiomyocyte ferroptosis via activating Nrf2/GPX4 signaling axis in heart failure.
Cheng P, Wang X, Liu Q, Yang T, Dai E, Sha W, Qu H, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155357
Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
Xu CY, Xu C, Xu YN, Du SQ, Dai ZH, Jin SQ, Zheng G, Xie CL, Fang WL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155342
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155342
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
Jiang Z, Qi G, He X, Yu Y, Cao Y, Zhang C, Zou W, Yuan H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(12):e2307388
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(12):e2307388
Lentinan inhibits cell invasion via M2 polarization of tumor-associated macrophages and Wnt/β-catenin signaling in non-small cell lung cancer.
Yang Y, Cheng Y, Mu Y, Tang X, Mu X
Chemical biology & drug design 2024 Mar;103(3):e14507
Chemical biology & drug design 2024 Mar;103(3):e14507
Exogenous hydrogen sulfide ameliorates diabetes-associated cognitive dysfunction by regulating the nrf-2/HO-1 axis and the NLRP3 inflammasome pathway in diabetic rats.
Chen H, Sun H, Hua W, Chang H, Chen W, Ma S
European journal of pharmacology 2024 Mar 5;966:176344
European journal of pharmacology 2024 Mar 5;966:176344
Integrated Transcriptomic and Proteomic Study of the Mechanism of Action of the Novel Small-Molecule Positive Allosteric Modulator 1 in Targeting PAC1-R for the Treatment of D-Gal-Induced Aging Mice.
Liang L, Chen S, Su W, Zhang H, Yu R
International journal of molecular sciences 2024 Mar 30;25(7)
International journal of molecular sciences 2024 Mar 30;25(7)
Securin acetylation prevents precocious separase activation and premature sister chromatid separation.
Wang T, Zou Y, Meng H, Zheng P, Teng J, Huang N, Chen J
Current biology : CB 2024 Mar 25;34(6):1295-1308.e5
Current biology : CB 2024 Mar 25;34(6):1295-1308.e5
African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway.
Ye G, Zhang Z, Liu X, Liu H, Chen W, Feng C, Li J, Zhou Q, Zhao D, Zhang S, Chen H, Bu Z, Huang L, Weng C
Journal of virology 2024 Mar 19;98(3):e0183423
Journal of virology 2024 Mar 19;98(3):e0183423
Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation.
Wang W, Zhou C, Ma Z, Zeng L, Wang H, Cheng X, Zhang C, Xue Y, Yuan Y, Li J, Hu L, Huang J, Luo T, Zheng L
Ecotoxicology and environmental safety 2024 Mar 15;273:116121
Ecotoxicology and environmental safety 2024 Mar 15;273:116121
ApoE maintains neuronal integrity via microRNA and H3K27me3-mediated repression.
Tan J, Tan YY, Ngian ZK, Chong SY, Rao VK, Wang JW, Zeng X, Ong CT
iScience 2024 Mar 15;27(3):109231
iScience 2024 Mar 15;27(3):109231
Different concentrations of betaxolol switch cell fate between necroptosis, apoptosis, and senescence in human corneal stromal cells.
Sun JY, Zhao J, Qiu Y, Fan TJ
Chemico-biological interactions 2024 Mar 1;391:110898
Chemico-biological interactions 2024 Mar 1;391:110898
Essential oil from Fructus Alpiniae zerumbet ameliorates vascular endothelial cell senescence in diabetes by regulating PPAR-γ signalling: A 4D label-free quantitative proteomics and network pharmacology study.
Liao J, Fu L, Tai S, Xu Y, Wang S, Guo L, Guo D, Du Y, He J, Yang H, Hu X, Tao L, Shen X
Journal of ethnopharmacology 2024 Mar 1;321:117550
Journal of ethnopharmacology 2024 Mar 1;321:117550
Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells.
Feng HW, Zhao Y, Gao YL, Liu DT, Huo LJ
Asian journal of andrology 2024 Mar 1;26(2):165-174
Asian journal of andrology 2024 Mar 1;26(2):165-174
The small nucleolar RNA SNORA51 enhances breast cancer stem cell-like properties via the RPL3/NPM1/c-MYC pathway.
Li S, Jin Z, Song X, Ma J, Peng Z, Yu H, Song J, Zhang Y, Sun X, He M, Yu X, Jin F, Zheng A
Molecular carcinogenesis 2024 Jun;63(6):1117-1132
Molecular carcinogenesis 2024 Jun;63(6):1117-1132
Sodium Butyrate Ameliorates Atopic Dermatitis-Induced Inflammation by Inhibiting HDAC3-Mediated STAT1 and NF-κB Pathway.
Hu C, Zeng D, Huang Y, Deng Q, Liu S, Zhou W, Zhou W
Inflammation 2024 Jun;47(3):989-1001
Inflammation 2024 Jun;47(3):989-1001
Arecoline induces neurotoxicity in HT22 cells via the promotion of endoplasmic reticulum stress and downregulation of the Nrf2/HO-1 pathway.
Yan H, Ding J, Li X, Li S, Zhang D
Environmental toxicology 2024 Jun;39(6):3410-3424
Environmental toxicology 2024 Jun;39(6):3410-3424
Inhibitor of apoptosis stimulating protein of p53 protects against MPP(+)-induced neurotoxicity of dopaminergic neurons.
Chen L, Duan F, Ge F, Tian L, Li Y, Li Y, Zhu Q, Zhou Q, Lin H
Metabolic brain disease 2024 Jun;39(5):871-884
Metabolic brain disease 2024 Jun;39(5):871-884
Myricanol attenuates sepsis-induced inflammatory responses by nuclear factor erythroid 2-related factor 2 signaling and nuclear factor kappa B/mitogen-activated protein kinase pathway via upregulating Sirtuin 1.
Liu K, Yang L, Wang P, Zhu J, Li F, Peng J, Huang K, Liang M
Inflammopharmacology 2024 Jun;32(3):1887-1901
Inflammopharmacology 2024 Jun;32(3):1887-1901
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA.
Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zhao G, Lu S, Zhuang H, Fan H, Li X, Liu Z, Lin S, Jiang H, Chen Y, Cheng J, Cao Z, Dai K, Shi J, Wang Z, Hu Y, Meng T, Zhou C, Han Z, Huang H, Zhou Q, He P, Feng D
Nature cell biology 2024 Jun;26(6):878-891
Nature cell biology 2024 Jun;26(6):878-891
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4.
Wang X, Chang HC, Gu X, Han W, Mao S, Lu L, Jiang S, Ding H, Han S, Qu X, Bao Z
Mechanisms of ageing and development 2024 Jun;219:111932
Mechanisms of ageing and development 2024 Jun;219:111932
Total flavonoids of Broussonetia papyrifera alleviate non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signaling pathways.
Wang Q, Wei Y, Wang Y, Yu Z, Qin H, Zhao L, Cheng J, Shen B, Jin M, Feng H
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Jun;1869(5):159497
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Jun;1869(5):159497
Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.
Wang H, Yuan S, Zheng Q, Zhang S, Zhang Q, Ji S, Wang W, Cao Y, Guo Y, Yang X, Geng H, Yang F, Xi S, Jin G, Zhang J, Gao Q, Bernards R, Qin W, Wang C
Gastroenterology 2024 Jun;166(6):1130-1144.e8
Gastroenterology 2024 Jun;166(6):1130-1144.e8
Tumor suppressive role of the epigenetic master regulator BRD3 in colorectal cancer.
Hashimoto M, Masuda T, Nakano Y, Tobo T, Saito H, Koike K, Takahashi J, Abe T, Ando Y, Ozato Y, Hosoda K, Higuchi S, Hisamatsu Y, Toshima T, Yonemura Y, Hata T, Uemura M, Eguchi H, Doki Y, Mori M, Mimori K
Cancer science 2024 Jun;115(6):1866-1880
Cancer science 2024 Jun;115(6):1866-1880
Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases.
Liao W, Li Y, Liu J, Mou Y, Zhao M, Liu J, Zhang T, Sun Q, Tang J, Wang Z
Cell communication and signaling : CCS 2024 Jun 7;22(1):315
Cell communication and signaling : CCS 2024 Jun 7;22(1):315
Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target.
Caldi Gomes L, Hänzelmann S, Hausmann F, Khatri R, Oller S, Parvaz M, Tzeplaeff L, Pasetto L, Gebelin M, Ebbing M, Holzapfel C, Columbro SF, Scozzari S, Knöferle J, Cordts I, Demleitner AF, Deschauer M, Dufke C, Sturm M, Zhou Q, Zelina P, Sudria-Lopez E, Haack TB, Streb S, Kuzma-Kozakiewicz M, Edbauer D, Pasterkamp RJ, Laczko E, Rehrauer H, Schlapbach R, Carapito C, Bonetto V, Bonn S, Lingor P
Nature communications 2024 Jun 7;15(1):4893
Nature communications 2024 Jun 7;15(1):4893
Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the Akt/mTOR Signaling Pathway.
Hu K, Wu S, Xu J, Zhang Y, Zhang Y, Wu X, Miao J, Yao Y, Zhu S, Chen G, Ren J
Journal of agricultural and food chemistry 2024 Jun 6;
Journal of agricultural and food chemistry 2024 Jun 6;
Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients.
Qiao X, van der Zanden SY, Li X, Tan M, Zhang Y, Song JY, van Gelder MA, Hamoen FL, Janssen L, Zuur CL, Pang B, van Tellingen O, Li J, Neefjes J
Molecular cancer 2024 Jun 4;23(1):120
Molecular cancer 2024 Jun 4;23(1):120
Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis.
Ma YL, Kong CY, Guo Z, Wang MY, Wang P, Liu FY, Yang D, Yang Z, Tang QZ
Nature communications 2024 Jun 4;15(1):4757
Nature communications 2024 Jun 4;15(1):4757
2'-Hydroxycinnamaldehyde Alleviates Intestinal Inflammation by Attenuating Intestinal Mucosal Barrier Damage Via Directly Inhibiting STAT3.
Chen M, Wei S, Wu X, Xiang Z, Li X, He H, Liao F, Wang X, Zhang J, Yu B, Dong W
Inflammatory bowel diseases 2024 Jun 3;30(6):992-1008
Inflammatory bowel diseases 2024 Jun 3;30(6):992-1008
Oncogenic functions and therapeutic potentials of targeted inhibition of SMARCAL1 in small cell lung cancer.
Sun BB, Wang GZ, Han SC, Yang FY, Guo H, Liu J, Liu YT, Zhou GB
Cancer letters 2024 Jun 28;592:216929
Cancer letters 2024 Jun 28;592:216929
Obg-like ATPase 1 exacerbated gemcitabine drug resistance of pancreatic cancer.
Liu J, Huang J, Lu J, Ouyang R, Xu W, Zhang J, Chen-Xiao K, Wu C, Shang D, Go VLWB, Guo J, Xiao GG
iScience 2024 Jun 21;27(6):110027
iScience 2024 Jun 21;27(6):110027
Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response.
Li Y, Song Y, Shi Z, Hou H, Yu Y, Pan F, Ji J, Chen Z
Cell death & disease 2024 Jun 19;15(6):431
Cell death & disease 2024 Jun 19;15(6):431
Asprosin promotes vascular inflammation via TLR4-NFκB-mediated NLRP3 inflammasome activation in hypertension.
Ge R, Chen JL, Zheng F, Yin SM, Dai M, Wang YM, Chen Q, Li YH, Zhu GQ, Chen AD
Heliyon 2024 Jun 15;10(11):e31659
Heliyon 2024 Jun 15;10(11):e31659
Transmissible gastroenteritis virus induces inflammatory responses via RIG-I/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo.
Zhang Y, Yang N, Li Y, Tan C, Cai Y, Rui X, Liu Y, Fu Y, Liu G
Journal of virology 2024 Jun 13;98(6):e0046124
Journal of virology 2024 Jun 13;98(6):e0046124
Amelioration of NAFLD by sleeve gastrectomy-triggered hepatocyte regeneration in mice - experimental research.
Yu T, Ma X, Cheng Y, Wang Z, Zhang G, Ding H, Yin J, Wang Y, Hu S
International journal of surgery (London, England) 2024 Jun 1;110(6):3307-3325
International journal of surgery (London, England) 2024 Jun 1;110(6):3307-3325
Chidamide enhances T-cell-mediated anti-tumor immune function by inhibiting NOTCH1/NFATC1 signaling pathway in ABC-type diffuse large B-cell lymphoma.
Li L, Yang W, Pan Y, Ye R, Wang Y, Li S, Jiang H, Zhang Q, Wang X, Yan J
Leukemia & lymphoma 2024 Jul;65(7):895-910
Leukemia & lymphoma 2024 Jul;65(7):895-910
Sleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating TGF-β1/Smad3 signaling pathway.
Liu C, Zhong M, Jin X, Zhu J, Cheng Y, Li L, Xu Q, Liu Q, Ding H, Zhang G
Journal of endocrinological investigation 2024 Jul;47(7):1763-1776
Journal of endocrinological investigation 2024 Jul;47(7):1763-1776
Energy stress promotes P-bodies formation via lysine-63-linked polyubiquitination of HAX1.
Zhan W, Li Z, Zhang J, Liu Y, Liu G, Li B, Shen R, Jiang Y, Shang W, Gao S, Wu H, Wang Y, Chen W, Wang Z
The EMBO journal 2024 Jul;43(13):2759-2788
The EMBO journal 2024 Jul;43(13):2759-2788
P7C3 suppresses astrocytic senescence to protect dopaminergic neurons: Implication in the mouse model of Parkinson's disease.
Chen Y, Zhu Z, Yan Y, Sun H, Wang G, Du X, Li F, Yuan S, Wang W, Wang M, Gu C
CNS neuroscience & therapeutics 2024 Jul;30(7):e14819
CNS neuroscience & therapeutics 2024 Jul;30(7):e14819
Tubular insulin-induced gene 1 deficiency promotes NAD(+) consumption and exacerbates kidney fibrosis.
Li S, Qin J, Zhao Y, Wang J, Huang S, Yu X
EMBO molecular medicine 2024 Jul;16(7):1675-1703
EMBO molecular medicine 2024 Jul;16(7):1675-1703
Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis.
Jiao M, Wang C, Tang X, Dai C, Zhang N, Fan A, Qian Z, Liu S, Zhang F, Li B, Xu Y, Tan Z, Gong F, Lu Y, Zheng F
Brain, behavior, and immunity 2024 Jul;119:539-553
Brain, behavior, and immunity 2024 Jul;119:539-553
Icariside II modulates pulmonary fibrosis via PI3K/Akt/β-catenin pathway inhibition of M2 macrophage program.
Deng L, Ouyang B, Tang W, Wang N, Yang F, Shi H, Zhang Z, Yu H, Chen M, Wei Y, Dong J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155687
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155687
Salvianolic acid B protects against UVB-induced skin aging via activation of NRF2.
Sun JM, Liu YX, Liu YD, Ho CK, Tsai YT, Wen DS, Huang L, Zheng DN, Gao Y, Zhang YF, Yu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155676
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155676
Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver.
Gan WL, Ren X, Ng VHE, Ng L, Song Y, Tano V, Han J, An O, Xie J, Ng BYL, Tay DJT, Tang SJ, Shen H, Khare S, Chong KHC, Young DY, Wu B, DasGupta R, Chen L
Cell reports 2024 Jul 23;43(7):114400
Cell reports 2024 Jul 23;43(7):114400
Excess endocrine growth hormone in acromegaly promotes the aggressiveness and metastasis of triple-negative breast cancer.
Kang CW, Oh JH, Wang EK, Bao Y, Kim YB, Lee MH, Lee YJ, Jo YS, Ku CR, Lee EJ
iScience 2024 Jul 19;27(7):110137
iScience 2024 Jul 19;27(7):110137
N1-Acetyl-5-methoxykynuramine, which decreases in the hippocampus with aging, improves long-term memory via CaMKII/CREB phosphorylation.
Watanabe K, Maruyama Y, Iwashita H, Kato H, Hirayama J, Hattori A
Journal of pineal research 2024 Jan;76(1):e12934
Journal of pineal research 2024 Jan;76(1):e12934
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Chen L, Qi E, Liu X, Cui L, Fan X, Wei T, Hu Y
Toxicology and applied pharmacology 2024 Jan;482:116766
Toxicology and applied pharmacology 2024 Jan;482:116766
Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry.
Su BQ, Yang GY, Wang J, Ming SL, Chu BB
PLoS pathogens 2024 Jan;20(1):e1011956
PLoS pathogens 2024 Jan;20(1):e1011956
Nuclear translocation of Axl contributes to the malignancy of oral cancer cells.
Su YF, Shen PC, Huang WY, Hung YJ, Huang TW, Lin CY, Shieh YS
Journal of dental sciences 2024 Jan;19(1):438-447
Journal of dental sciences 2024 Jan;19(1):438-447
SETD2 loss in renal epithelial cells drives epithelial-to-mesenchymal transition in a TGF-β-independent manner.
Wang T, Wagner RT, Hlady RA, Pan X, Zhao X, Kim S, Wang L, Lee JH, Luo H, Castle EP, Lake DF, Ho TH, Robertson KD
Molecular oncology 2024 Jan;18(1):44-61
Molecular oncology 2024 Jan;18(1):44-61
Osteoblast-derived exosomes promote osteogenic differentiation of osteosarcoma cells via URG4/Wnt signaling pathway.
Leng Y, Li J, Long Z, Li C, Zhang L, Huang Z, Xi J, Liu Y
Bone 2024 Jan;178:116933
Bone 2024 Jan;178:116933
Metformin: A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation.
Yang T, Yuan J, Peng Y, Pang J, Qiu Z, Chen S, Huang Y, Jiang Z, Fan Y, Liu J, Wang T, Zhou X, Qian S, Song J, Xu Y, Lu Q, Yin X
Journal of pharmaceutical analysis 2024 Jan;14(1):52-68
Journal of pharmaceutical analysis 2024 Jan;14(1):52-68
A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.
Schmit MM, Baxley RM, Wang L, Hinderlie P, Kaufman M, Simon E, Raju A, Miller JS, Bielinsky AK
Open biology 2024 Jan;14(1):230407
Open biology 2024 Jan;14(1):230407
Chlorogenic acid regulates the expression of NPC1L1 and HMGCR through PXR and SREBP2 signaling pathways and their interactions with HSP90 to maintain cholesterol homeostasis.
Meng C, Zhou L, Huang L, Gu Q, Du X, Wang C, Liu F, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155271
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155271
Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex.
Ren Y, Wu H, Tan M, Chen J, Duan Z, Zhu B, Ruan X, Yu Q, Li S, Liu X, Liu Y, Si Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155152
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155152
Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype.
Liang Y, Pan C, Yin T, Wang L, Gao X, Wang E, Quang H, Huang D, Tan L, Xiang K, Wang Y, Alexander PB, Li QJ, Yao TP, Zhang Z, Wang XF
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2303489
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2303489
Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH-SY5Y cells and Caenorhabditis elegans.
Hu K, Zhu S, Wu F, Zhang Y, Li M, Yuan L, Huang W, Zhang Y, Wang J, Ren J, Yang H
Chemico-biological interactions 2024 Jan 5;387:110824
Chemico-biological interactions 2024 Jan 5;387:110824
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.
Huang J, Zhang X, Yang X, Yv Q, Ye F, Chen S, Cui Y, Gu L, Zhu M, Li W
Chemico-biological interactions 2024 Jan 5;387:110820
Chemico-biological interactions 2024 Jan 5;387:110820
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells.
Xia Q, Xie J, Zhang J, Zhang L, Zhou Y, Zhu B, Wu Y, Yang Z, Li J
Chemico-biological interactions 2024 Jan 5;387:110819
Chemico-biological interactions 2024 Jan 5;387:110819
Jianpi Huayu Decoction suppresses cellular senescence in colorectal cancer via p53-p21-Rb pathway: Network pharmacology and in vivo validation.
Wang S, Xing Y, Wang R, Jin Z
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117347
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117347
Selenium suppressed the LPS-induced oxidative stress of bovine endometrial stromal cells through Nrf2 pathway with high cortisol background.
Cui L, Zheng F, Zhang M, Wang Z, Meng X, Dong J, Liu K, Guo L, Wang H, Li J
Journal of animal science 2024 Jan 3;102
Journal of animal science 2024 Jan 3;102
Taurine Chloramine-Mediated Nrf2 Activation and HO-1 Induction Confer Protective Effects in Astrocytes.
Seol SI, Kang IS, Lee JS, Lee JK, Kim C
Antioxidants (Basel, Switzerland) 2024 Jan 29;13(2)
Antioxidants (Basel, Switzerland) 2024 Jan 29;13(2)
A complex of cadherin 17 with desmocollin 1 and p120-catenin regulates colorectal cancer migration and invasion according to the cell phenotype.
Bartolomé RA, Pintado-Berninches L, Martín-Regalado Á, Robles J, Calvo-López T, Ortega-Zapero M, Llorente-Sáez C, Boukich I, Fernandez-Aceñero MJ, Casal JI
Journal of experimental & clinical cancer research : CR 2024 Jan 24;43(1):31
Journal of experimental & clinical cancer research : CR 2024 Jan 24;43(1):31
NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1.
Cao JH, Cao CH, Lin JL, Li SY, He LJ, Han K, Chen JW, Li S, Wang X, Xie D, Wang FW
Cell reports 2024 Jan 23;43(1):113654
Cell reports 2024 Jan 23;43(1):113654
Discovery from Hypericum elatoides and synthesis of hyperelanitriles as α-aminopropionitrile-containing polycyclic polyprenylated acylphloroglucinols.
Xie JY, Li P, Yan XT, Gao JM
Communications chemistry 2024 Jan 2;7(1):1
Communications chemistry 2024 Jan 2;7(1):1
Dietary long-chain fatty acids promote colitis by regulating palmitoylation of STAT3 through CD36-mediated endocytosis.
Wei Y, Li J, Li J, Liu C, Guo X, Liu Z, Zhang L, Bao S, Wu X, Su W, Wang X, Zhang J, Dong W
Cell death & disease 2024 Jan 17;15(1):60
Cell death & disease 2024 Jan 17;15(1):60
Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells.
Yamada A, Wake K, Imaoka S, Motoyoshi M, Yamamoto T, Asano M
Scientific reports 2024 Jan 15;14(1):1322
Scientific reports 2024 Jan 15;14(1):1322
Acylated Ghrelin Activates PI3K/mTOR Signaling Pathway by Promoting ThPOK Acetylation to Promote Milk Fat Synthesis in Bovine Mammary Epithelial Cells.
Wang J, Cao Y, Long X, Li F, Jiang N, Sun M, Xie Y, Ge Y, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 Jan 10;72(1):390-404
Journal of agricultural and food chemistry 2024 Jan 10;72(1):390-404
Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.
Huang H, Sun Z, Xu J, Wang L, Zhao J, Li J, Zhang S, Yuan F, Liu M, Fang Z
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116868
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116868
Heterologous expression of Dictyostelium discoideum NE81 in mouse embryo fibroblasts reveals conserved mechanoprotective roles of lamins.
Odell J, Gräf R, Lammerding J
Molecular biology of the cell 2024 Jan 1;35(1):ar7
Molecular biology of the cell 2024 Jan 1;35(1):ar7
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cascade.
Yang F, Lian Q, Zhang X, Sun F, Jia S, Zhao W
Toxicology and applied pharmacology 2024 Feb;483:116829
Toxicology and applied pharmacology 2024 Feb;483:116829
LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages.
Guo D, Dong W, Cong Y, Liu Y, Liang Y, Ye Z, Zhang J, Zhou Y
Inflammation 2024 Feb;47(1):307-322
Inflammation 2024 Feb;47(1):307-322
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.
Son SM, Park SJ, Breusegem SY, Larrieu D, Rubinsztein DC
Nature cell biology 2024 Feb;26(2):235-249
Nature cell biology 2024 Feb;26(2):235-249
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis.
Hattori T, Fundora KA, Hamamoto K, Opozda DM, Liang X, Liu X, Zhang J, Uzun Y, Takahashi Y, Wang HG
Autophagy 2024 Feb;20(2):349-364
Autophagy 2024 Feb;20(2):349-364
Sodium butyrate alleviates lead-induced neuroinflammation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway.
Li Y, Liu A, Chen K, Li L, Zhang X, Zou F, Zhang X, Meng X
Environment international 2024 Feb;184:108479
Environment international 2024 Feb;184:108479
The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis.
Zhong X, Wei X, Xu Y, Zhu X, Huo B, Guo X, Feng G, Zhang Z, Feng X, Fang Z, Luo Y, Yi X, Jiang DS
Acta pharmaceutica Sinica. B 2024 Feb;14(2):712-728
Acta pharmaceutica Sinica. B 2024 Feb;14(2):712-728
NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition.
Wang Z, Su Y, Zhao M, Ma Z, Li J, Hou Z, Li H
Animals : an open access journal from MDPI 2024 Feb 9;14(4)
Animals : an open access journal from MDPI 2024 Feb 9;14(4)
Peroxiredoxin 3 regulates breast cancer progression via ERK-mediated MMP-1 expression.
Chua PJ, Ow SH, Ng CT, Huang WH, Low JT, Tan PH, Chan MWY, Bay BH
Cancer cell international 2024 Feb 6;24(1):59
Cancer cell international 2024 Feb 6;24(1):59
Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis.
Li S, Xue X, Zhang H, Jiang L, Zhang Y, Zhu X, Wang Y
Chemico-biological interactions 2024 Feb 25;390:110868
Chemico-biological interactions 2024 Feb 25;390:110868
MKK3 K329 Mutation Attenuates Diabetes-Associated Cognitive Dysfunction by Blocking the MKK3-RAGE Interaction and Inhibiting Neuroinflammation.
Ying C, Li Y, Wu S, Gao L, Zhu Y, Qian Y, Wen X, Li H, Huang C, Hu B, Song Y, Zhou X
Aging and disease 2024 Feb 22;16(1):598-618
Aging and disease 2024 Feb 22;16(1):598-618
A GAPDH serotonylation system couples CD8(+) T cell glycolytic metabolism to antitumor immunity.
Wang X, Fu SQ, Yuan X, Yu F, Ji Q, Tang HW, Li RK, Huang S, Huang PQ, Qin WT, Zuo H, Du C, Yao LL, Li H, Li J, Li DX, Yang Y, Xiao SY, Tulamaiti A, Wang XF, Dai CH, Zhang X, Jiang SH, Hu LP, Zhang XL, Zhang ZG
Molecular cell 2024 Feb 15;84(4):760-775.e7
Molecular cell 2024 Feb 15;84(4):760-775.e7
Self-Healing Micro Arc Oxidation and Dicalcium Phosphate Dihydrate Double-Passivated Coating on Magnesium Membrane for Enhanced Bone Integration Repair.
Wu J, Shen Y, Wang P, Guo Z, Bai J, Wang X, Chen D, Lin X, Tang C
ACS biomaterials science & engineering 2024 Feb 12;10(2):1062-1076
ACS biomaterials science & engineering 2024 Feb 12;10(2):1062-1076
OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
Ma W, Sun Y, Yan R, Zhang P, Shen S, Lu H, Zhou Z, Jiang Z, Ye L, Mao Q, Xiong N, Jia W, Sun L, Gao P, Zhang H
Molecular cell 2024 Feb 1;84(3):538-551.e7
Molecular cell 2024 Feb 1;84(3):538-551.e7
Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation.
Hu Y, Nan Y, Lin H, Zhao Q, Chen T, Tao X, Ding B, Lu L, Chen S, Zhu J, Guo X, Lin Z
Pediatric research 2024 Dec;96(7):1681-1692
Pediatric research 2024 Dec;96(7):1681-1692
Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling.
Ge X, Gu Y, Wang W, Guo W, Wang P, Du P
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2069-2085
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2069-2085
Protein arginine methyltransferase 5 confers the resistance of triple-negative breast cancer to nanoparticle albumin-bound paclitaxel by enhancing autophagy through the dimethylation of ULK1.
Kong J, Dong Y, Li M, Fan J, Wang T
Toxicology and applied pharmacology 2024 Dec;493:117145
Toxicology and applied pharmacology 2024 Dec;493:117145
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma.
Qiao Q, Wang J, Liu S, Chang J, Zhou T, Li C, Zhang Y, Jiang W, Chen Y, Xu X, Wu M, Li X
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2217-2231
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2217-2231
TGN-020 ameliorates motor dysfunction post-spinal cord injury via enhancing astrocyte autophagy and mitigating inflammation by activating AQP4/PPAR-γ/mTOR pathway.
Kong J, Zhang Q, Zheng H, Tang D, Fang L, An S, Li J, Fan Z
Experimental neurology 2024 Dec;382:114975
Experimental neurology 2024 Dec;382:114975
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels.
Nose K, Taniguchi K, Fujita M, Moyama C, Mori M, Ishita M, Yoshida T, Ii H, Sakai T, Nakata S
Cancer gene therapy 2024 Dec;31(12):1831-1839
Cancer gene therapy 2024 Dec;31(12):1831-1839
The noncanonical RNA-binding protein RAN stabilizes the mRNA of intranuclear stress granule assembly factor G3BP1 in nasopharyngeal carcinoma.
Yang PY, Yang Z, Lv J, Jiang PY, Quan TQ, Huang ZH, Xu XD, Guo R, Wei D, Sun Y
The Journal of biological chemistry 2024 Dec;300(12):107964
The Journal of biological chemistry 2024 Dec;300(12):107964
Porcine reproductive and respiratory syndrome virus activates lipid synthesis through a ROS-dependent AKT/PCK1/INSIG/SREBPs axis.
Ma YX, Han YQ, Wang PZ, Wang MY, Yang GY, Li JL, Wang J, Chu BB
International journal of biological macromolecules 2024 Dec;282(Pt 1):136720
International journal of biological macromolecules 2024 Dec;282(Pt 1):136720
An artificial peptide inhibits autophagy through calcineurin-TFEB pathway.
Yang Y, Li Y, Shang H, Liu Y, Li W, Chen L, Cheng N, Zhang Y, Zhang N, Yin Y, Tong L, Li Z, Yang J, Luo J
Biochimica et biophysica acta. Molecular cell research 2024 Dec;1871(8):119853
Biochimica et biophysica acta. Molecular cell research 2024 Dec;1871(8):119853
Discovery of novel 5-phenyl-1H-pyrrole-2-carboxylic acids as Keap1-Nrf2 inhibitors for acute lung injury treatment.
Tang J, Tie X, Zhi S, Wang Z, Zhao Q, Qu Z, Lu G, Li Q, Wu Y, Shi Y
Bioorganic chemistry 2024 Dec;153:107741
Bioorganic chemistry 2024 Dec;153:107741
Bushen Huoxue Yiqi formula alleviates cardiac fibrosis in ischemic heart failure through SIRT1/Notch1 pathway-mediated EndMT.
Chen C, Wang J, Hou C, Lian W, Zhu X, Hu J, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156252
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156252
The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα.
Wang T, Luo R, Zhang J, Lan J, Lu Z, Zhai H, Li LF, Sun Y, Qiu HJ
Emerging microbes & infections 2024 Dec;13(1):2333381
Emerging microbes & infections 2024 Dec;13(1):2333381
Impact of Nuclear Peripheral Chromatin Lamin LMNB1 Gene in the Proliferation and Migration of Glioma Cells.
Shi XC, Zhang T, Li C, Guo CJ, Yang Q, Feng Y, Wang J, Qu CX
Neurochemical research 2024 Dec 5;50(1):46
Neurochemical research 2024 Dec 5;50(1):46
Maternal exposure to 4-tert-octylphenol causes alterations in the morphology and function of microglia in the offspring mouse brain.
Lee SH, Shin HS, So YH, Lee DH, An BS, Lee GS, Jung EM
Journal of hazardous materials 2024 Dec 5;480:136258
Journal of hazardous materials 2024 Dec 5;480:136258
Lycopodium japonicum Thunb. inhibits chondrocyte apoptosis, senescence and inflammation in osteoarthritis through STING/NF-κB signaling pathway.
Ma J, Zhang H, Wang Z, Xu C, Tan H, Sun Y, Zheng R, Jin Z, Li Y, Ge X, Wu Y, Zhou Y
Journal of ethnopharmacology 2024 Dec 5;335:118660
Journal of ethnopharmacology 2024 Dec 5;335:118660
A low level of tumor necrosis factor α in tumor microenvironment maintains the self-renewal of glioma stem cells by Vasorin-mediated glycolysis.
Zhang Y, Kang T, Wang Y, Song C, Li H, Mi H, Li Y, Dong M, Ma X, Zhu H, Cheng L, Zhang P, Chen Z, Zhou L, Wu Q, Mao F, Wang B, Zhang S, Shu K, Wan F, Zhou W, Rich JN, Shen J, Xiao Q, Yu X
Neuro-oncology 2024 Dec 5;26(12):2256-2271
Neuro-oncology 2024 Dec 5;26(12):2256-2271
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Yu H, Liang J, Bao Y, Chen K, Jin Y, Li X, Chen H, Gou Y, Lu K, Lin Z
International immunopharmacology 2024 Dec 5;142(Pt B):113116
International immunopharmacology 2024 Dec 5;142(Pt B):113116
Nuciferine ameliorates osteoarthritis: An in vitro and in vivo study.
Peng M, Shen G, Tu Q, Zhang W, Wang J
International immunopharmacology 2024 Dec 5;142(Pt B):113098
International immunopharmacology 2024 Dec 5;142(Pt B):113098
Subcellular Proteomic Mapping of Lysine Lactylation.
Bao Q, Wan N, He Z, Cao J, Yuan W, Hao H, Ye H
Journal of the American Society for Mass Spectrometry 2024 Dec 4;35(12):3221-3232
Journal of the American Society for Mass Spectrometry 2024 Dec 4;35(12):3221-3232
Impeding Nucleotide-Binding Oligomerization Domain-Like Receptor 3 Inflammasome Ameliorates Cardiac Remodeling and Dysfunction in Obesity-Associated Cardiomyopathy.
Liu SQ, Xie SY, Zhang T, Zhang H, Chen MY, Xing Y, Zhao N, Li L, Chen S, Wang SS, Zeng XF, Deng W, Tang QZ
Journal of the American Heart Association 2024 Dec 3;13(23):e035234
Journal of the American Heart Association 2024 Dec 3;13(23):e035234
Mesenchymal stromal cells reduce inflammation and improve lung function in a mouse model of cystic fibrosis lung disease.
Doherty DF, Roets LE, Dougan CM, Brown RR, Hawthorne IJ, O'Kane C, Krasnodembskaya AD, Mall MA, Taggart CC, Weldon S
Scientific reports 2024 Dec 28;14(1):30899
Scientific reports 2024 Dec 28;14(1):30899
Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO-1 pathway.
Chen SY, Xu H, Qin Y, He TQ, Shi RR, Xing YR, Xu J, Cong RC, Wang MR, Yang JS, Gu JH, He BS
International immunopharmacology 2024 Dec 25;143(Pt 2):113478
International immunopharmacology 2024 Dec 25;143(Pt 2):113478
Isolicoflavonol ameliorates acute liver injury via inhibiting NLRP3 inflammasome activation through boosting Nrf2 signaling in vitro and in vivo.
Zhang XJ, Pu YK, Yang PY, Wang MR, Zhang RH, Li XL, Xiao WL
International immunopharmacology 2024 Dec 25;143(Pt 1):113233
International immunopharmacology 2024 Dec 25;143(Pt 1):113233
M6A modification-mediated LIMA1 promotes the progression of hepatocellular carcinoma through the wnt-βcatenin/Hippo pathway.
Zhang C, Wang X, Song H, Yuan J, Zhang X, Yuan Y, Wang Z, Lei Z, He J
Cell biology and toxicology 2024 Dec 21;41(1):9
Cell biology and toxicology 2024 Dec 21;41(1):9
Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways.
Dong J, Wang Z, Fei F, Jiang Y, Jiang Y, Guo L, Liu K, Cui L, Meng X, Li J, Wang H
Veterinary sciences 2024 Dec 21;11(12)
Veterinary sciences 2024 Dec 21;11(12)
Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases.
Wang Z, Liu J, Mou Y, Li Y, Liao W, Yao M, Wang T, Shen H, Sun Q, Tang J
Molecular medicine (Cambridge, Mass.) 2024 Dec 19;30(1):245
Molecular medicine (Cambridge, Mass.) 2024 Dec 19;30(1):245
Alpha-lipoic acid targets KLF7 expression to inhibit cervical cancer progression.
Mao Y, Li H, Xu G, Tian J, Chen Y, Zhang Z
Acta biochimica et biophysica Sinica 2024 Dec 17;57(2):237-249
Acta biochimica et biophysica Sinica 2024 Dec 17;57(2):237-249
BRD7 regulates cellular senescence and apoptosis in ALS by modulating p21 expression and p53 mitochondrial translocation respectively.
Tan X, Su X, Wang Y, Liang W, Wang D, Huo D, Wang H, Qi Y, Zhang W, Han L, Zhang D, Wang M, Xu J, Feng H
Neuroscience 2024 Dec 17;563:51-62
Neuroscience 2024 Dec 17;563:51-62
Matrix stiffness regulates macrophage polarisation via the Piezo1-YAP signalling axis.
Mei F, Guo Y, Wang Y, Zhou Y, Heng BC, Xie M, Huang X, Zhang S, Ding S, Liu F, Deng X, Chen L, Yang C
Cell proliferation 2024 Aug;57(8):e13640
Cell proliferation 2024 Aug;57(8):e13640
Serum deprivation protein response intervenes in the proliferation, motility, and extracellular matrix production in keloid fibroblasts by blocking the amplification of TGF-β1/SMAD signal cascade via ERK1/2.
Li P, Han M, Wang L, Gao C
Toxicology and applied pharmacology 2024 Aug;489:117012
Toxicology and applied pharmacology 2024 Aug;489:117012
STIL facilitates the development and malignant progression of triple-negative breast cancer through activation of Fanconi anemia pathway via interacting with KLF16.
Wang M, Pan B, Hu Y, Gao J, Hou L, Yu Z, Li M, Zhao Z
Translational oncology 2024 Aug;46:102010
Translational oncology 2024 Aug;46:102010
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport.
Wu Y, Zheng W, Xu G, Zhu L, Li Z, Chen J, Wang L, Chen S
Cell death and differentiation 2024 Aug;31(8):1070-1084
Cell death and differentiation 2024 Aug;31(8):1070-1084
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer.
Wang Z, Zhao N, Zhang S, Wang D, Wang S, Liu N
Pharmacological research 2024 Aug;206:107283
Pharmacological research 2024 Aug;206:107283
Erastin promotes random-pattern skin flaps survival by inducing mTORC1-TFEB mediated autophagy.
Chen X, Zhu X, Chen Y, Ruan Z, Zhang Y, Wu H, Zhang X, Gao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116918
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116918
Reversing MET-Mediated Resistance in Oncogene-Driven NSCLC by MET-Activated Wnt Condensative Prodrug.
Liu N, Zheng X, Yan J, Jiang A, Yao Y, He W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2400603
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2400603
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
Nie P, Zhang C, Wu F, Chen S, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2.
Yang CL, Wang FX, Luo JH, Rong SJ, Lu WY, Chen QJ, Xiao J, Wang T, Song DN, Liu J, Mo Q, Li S, Chen Y, Wang YN, Liu YJ, Yan T, Gu WK, Zhang S, Xiong F, Yu QL, Zhang ZY, Yang P, Liu SW, Eizirik D, Dong LL, Sun F, Wang CY
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Aug 7;32(8):2778-2797
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Aug 7;32(8):2778-2797
βA3/A1-crystallin is an epigenetic regulator of histone deacetylase 3 (HDAC3) in the retinal pigmented epithelial (RPE) cells.
Chatterjee S, Ghosh S, Sin Z, Davis E, Preval LV, Tran N, Bammidi S, Gautam P, Hose S, Sergeev Y, Flores-Bellver M, Aldiri I, Sinha D, Guha P
bioRxiv : the preprint server for biology 2024 Aug 7;
bioRxiv : the preprint server for biology 2024 Aug 7;
Air-ventilated normothermic mechanical perfusion improves susceptibility to donation after circulatory death and cold preservation-induced cholestatic liver injury through PPAR-γ/UGT1A1 axis.
Wang Y, Tao RL, Yu DS, Wu KW, Bai Y, Yang DJ, Gu Y, Guo WZ, Zhang SJ, Jin Y, Shi JH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 31;38(16):e70014
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 31;38(16):e70014
Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironment.
Wang H, Yung MM, Xuan Y, Chen F, Chan W, Siu MK, Long R, Jia S, Liang Y, Xu D, Song Z, Tsui SK, Ngan HY, Chan KK, Chan DW
Experimental hematology & oncology 2024 Aug 28;13(1):90
Experimental hematology & oncology 2024 Aug 28;13(1):90
SMYD5 is a regulator of the mild hypothermia response.
Rafnsdottir S, Jang K, Halldorsdottir ST, Vinod M, Tomasdottir A, Möller K, Halldorsdottir K, Reynisdottir T, Atladottir LH, Allison KE, Ostacolo K, He J, Zhang L, Northington FJ, Magnusdottir E, Chavez-Valdez R, Anderson KJ, Bjornsson HT
Cell reports 2024 Aug 27;43(8):114554
Cell reports 2024 Aug 27;43(8):114554
SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion.
Kim H, Choi IA, Umemoto A, Bae S, Kaneko K, Mizuno M, Giannopoulou E, Pannellini T, Deng L, Park-Min KH
Bone research 2024 Aug 27;12(1):48
Bone research 2024 Aug 27;12(1):48
Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy.
Yang S, Zhu Y, Shi Y, Su S, Liang H, Li S, Wu Z, Miao J, Chen Y, Zhang X, Wang X
Free radical biology & medicine 2024 Aug 20;221:245-256
Free radical biology & medicine 2024 Aug 20;221:245-256
Immunomodulation in Endometriosis: Investigating the interrelationship between VISTA expression and Escherichia.Shigella-Associated metabolites.
Chen Y, Che X, Rong Y, Zhu J, Yu Y, Xu H, Sun Y, Chen H, Yan L, Chen L, Xu Y, Zhang J
International immunopharmacology 2024 Aug 20;137:112366
International immunopharmacology 2024 Aug 20;137:112366
Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I.
Dong H, Wen C, He L, Zhang J, Xiang N, Liang L, Hu L, Li W, Liu J, Shi M, Hu Y, Chen S, Liu H, Yang X
Journal of translational medicine 2024 Aug 14;22(1):769
Journal of translational medicine 2024 Aug 14;22(1):769
Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation.
Bao L, Zhu J, Shi T, Jiang Y, Li B, Huang J, Ji X
Nucleic acids research 2024 Aug 12;52(14):8165-8183
Nucleic acids research 2024 Aug 12;52(14):8165-8183
Breast cancer cells have an increased ferroptosis risk induced by system x(c)(-) blockade after deliberately downregulating CYTL1 to mediate malignancy.
Xue W, Yu Y, Yao Y, Zhou L, Huang Y, Wang Y, Chen Z, Wang L, Li X, Wang X, Du R, Shen Y, Xu Q
Redox biology 2024 Apr;70:103034
Redox biology 2024 Apr;70:103034
CRISPR/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt/β-catenin signaling pathway.
Han H, Xu M, Wang J, Li MD, Yang Z
Journal of advanced research 2024 Apr;58:129-138
Journal of advanced research 2024 Apr;58:129-138
Icariin alleviates renal inflammation and tubulointerstitial fibrosis via Nrf2-mediated attenuation of mitochondrial damage.
Ding N, Sun S, Zhou S, Lv Z, Wang R
Cell biochemistry and function 2024 Apr;42(3):e4005
Cell biochemistry and function 2024 Apr;42(3):e4005
Ursolic acid attenuates cholestasis through NRF2-mediated regulation of UGT2B7 and BSEP/MRP2.
Wang X, Xiong W, Wang X, Qin L, Zhong M, Liu Y, Xiong Y, Yi X, Wang X, Zhang H
Naunyn-Schmiedeberg's archives of pharmacology 2024 Apr;397(4):2257-2267
Naunyn-Schmiedeberg's archives of pharmacology 2024 Apr;397(4):2257-2267
Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells.
Albuquerque-Souza E, Shelling B, Jiang M, Xia XJ, Rattanaprukskul K, Sahingur SE
Molecular oral microbiology 2024 Apr;39(2):29-39
Molecular oral microbiology 2024 Apr;39(2):29-39
Pimpinellin ameliorates macrophage inflammation by promoting RNF146-mediated PARP1 ubiquitination.
Yang L, Du M, Liu K, Wang P, Zhu J, Li F, Wang Z, Huang K, Liang M
Phytotherapy research : PTR 2024 Apr;38(4):1783-1798
Phytotherapy research : PTR 2024 Apr;38(4):1783-1798
Danshensu methyl ester attenuated LPS-induced acute lung injury by inhibiting TLR4/NF-κB pathway.
Han X, Ding W, Qu G, Li Y, Wang P, Yu J, Liu M, Chen X, Xie S, Feng J, Xu S
Respiratory physiology & neurobiology 2024 Apr;322:104219
Respiratory physiology & neurobiology 2024 Apr;322:104219
GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway.
Mengjia W, Jun J, Xin Z, Jiahao Z, Jie G
Journal of cellular and molecular medicine 2024 Apr;28(7):e18231
Journal of cellular and molecular medicine 2024 Apr;28(7):e18231
Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1.
Yang Y, Zhang J, Lv M, Cui N, Shan B, Sun Q, Yan L, Zhang M, Zou C, Yuan J, Xu D
Nature cell biology 2024 Apr;26(4):567-580
Nature cell biology 2024 Apr;26(4):567-580
Nucleoporin93 limits Yap activity to prevent endothelial cell senescence.
Nguyen TD, Rao MK, Dhyani SP, Banks JM, Winek MA, Michalkiewicz J, Lee MY
Aging cell 2024 Apr;23(4):e14095
Aging cell 2024 Apr;23(4):e14095
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.
Zhou Q, Shi D, Tang YD, Zhang L, Hu B, Zheng C, Huang L, Weng C
PLoS pathogens 2024 Apr;20(4):e1012146
PLoS pathogens 2024 Apr;20(4):e1012146
African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways.
Liu X, Chen H, Ye G, Liu H, Feng C, Chen W, Hu L, Zhou Q, Zhang Z, Li J, Zhang X, He X, Guan Y, Wu Z, Zhao D, Bu Z, Weng C, Huang L
PLoS pathogens 2024 Apr;20(4):e1012136
PLoS pathogens 2024 Apr;20(4):e1012136
SIRT1-dependent PGC-1α deacetylation by SRT1720 rescues progression of atherosclerosis by enhancing mitochondrial function.
Sung JY, Kim SG, Kang YJ, Park SY, Choi HC
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Apr;1869(3):159453
Biochimica et biophysica acta. Molecular and cell biology of lipids 2024 Apr;1869(3):159453
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
Dai Y, Xu R, Chen J, Fang J, Zhang H, Li H, Chen W
British journal of pharmacology 2024 Apr;181(7):967-986
British journal of pharmacology 2024 Apr;181(7):967-986
Baicalein ameliorated obesity-induced cardiac dysfunction by regulating the mitochondrial unfolded protein response through NRF2 signaling.
Guo L, Yang J, Yuan W, Li C, Li H, Yang Y, Xue R, Yan K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155441
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155441
Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction.
Cai F, Li D, Zhou K, Zhang W, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155407
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155407
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection.
Wu W, Arunagiri V, Do-Umehara HC, Chen C, Gu S, Biswas I, Ridge KM, Budinger GRS, Liu S, Liu J
Science signaling 2024 Apr 9;17(831):eadg7867
Science signaling 2024 Apr 9;17(831):eadg7867
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Zeng Q, Wen BB, Liu X, Luo YY, Hu ZG, Huang L, Zhang XH, Huang XT, Zhou TT, Sang XX, Luo YY, Xiong DY, Luo ZQ, Liu W, Tang SY
Chinese medicine 2024 Apr 8;19(1):60
Chinese medicine 2024 Apr 8;19(1):60
TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1.
Cai Y, Li Y, Xu Y, Yang W, Huang M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 30;38(8):e23625
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 30;38(8):e23625
Procyanidin B2 alleviates oxidized low-density lipoprotein-induced cell injury, inflammation, monocyte chemotaxis, and oxidative stress by inhibiting the nuclear factor kappa-B pathway in human umbilical vein endothelial cells.
Yuan L, Fan L, Zhang Z, Huang X, Liu Q, Zhang Z
BMC cardiovascular disorders 2024 Apr 29;24(1):231
BMC cardiovascular disorders 2024 Apr 29;24(1):231
Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis.
Peng Y, Yang Y, Li Y, Shi T, Xu N, Liu R, Luan Y, Yao Y, Yin C
Cellular & molecular biology letters 2024 Apr 27;29(1):61
Cellular & molecular biology letters 2024 Apr 27;29(1):61
CAV3 alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction.
Guo P, Hu S, Liu X, He M, Li J, Ma T, Huang M, Fang Q, Wang Y
Journal of translational medicine 2024 Apr 26;22(1):390
Journal of translational medicine 2024 Apr 26;22(1):390
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.
Shi Y, Huang D, Song C, Cao R, Wang Z, Wang D, Zhao L, Xu X, Lu C, Xiong F, Zhao H, Li S, Zhou Q, Luo S, Hu D, Zhang Y, Wang C, Shen Y, Su W, Wu Y, Schmitz K, Wei S, Song W
Nature communications 2024 Apr 26;15(1):3301
Nature communications 2024 Apr 26;15(1):3301
Rosamultin ameliorates radiation injury via promoting DNA injury repair and suppressing oxidative stress in vitro and in vivo.
Liu N, Niu M, Luo S, Lv L, Quan X, Wang C, Meng Z, Yuan J, Xu Q, Liu Y
Chemico-biological interactions 2024 Apr 25;393:110938
Chemico-biological interactions 2024 Apr 25;393:110938
Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway.
Zhu M, Han Y, Gu T, Wang R, Si X, Kong D, Zhao P, Wang X, Li J, Zhai X, Yu Z, Lu H, Li J, Huang H, Qian P
Cell reports 2024 Apr 23;43(4):114065
Cell reports 2024 Apr 23;43(4):114065
Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation.
Zhou X, Zhu Y, Gao D, Li M, Lin L, Wang Z, Du H, Xu Y, Liu J, He Y, Guo Y, Wang S, Qiao S, Bao Y, Liu Y, Zhang H
Cell reports 2024 Apr 23;43(4):113980
Cell reports 2024 Apr 23;43(4):113980
C6orf15 promotes liver metastasis via WNT/β-catenin signalling in colorectal cancer.
Yu J, Sun J, Tang J, Xu J, Qian G, Zhou J
Cancer cell international 2024 Apr 23;24(1):146
Cancer cell international 2024 Apr 23;24(1):146
CMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells.
Zhao R, Guo X, Zhang G, Liu S, Ma R, Wang M, Chen S, Zhu W, Liu Y, Gao P, Liu H
Cell death & disease 2024 Apr 23;15(4):288
Cell death & disease 2024 Apr 23;15(4):288
Investigating the role of itaconate in macrophage activation and oxidative stress injury in sepsis-associated acute kidney injury.
Yang L, Zhou P, Li R, Yin Y, Xie G, Shi L, Zhang P, Tao K
Molecular biology reports 2024 Apr 20;51(1):533
Molecular biology reports 2024 Apr 20;51(1):533
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789
International immunopharmacology 2024 Apr 20;131:111789
The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis.
Wang Z, Li T, Liu D, Li M, Liu S, Yu X, Li H, Song H, Zhao W, Liu Z, Chen X, Lu G, Chen ZJ, Huang T, Liu H
iScience 2024 Apr 19;27(4):109456
iScience 2024 Apr 19;27(4):109456
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Wang Z, Dong Z, Li Y, Jiao X, Liu Y, Chang H, Gan Y
Biomedicines 2024 Apr 18;12(4)
Biomedicines 2024 Apr 18;12(4)
LINE-1 mRNA 3' end dynamics shape its biology and retrotransposition potential.
Janecki DM, Sen R, Szóstak N, Kajdasz A, Kordyś M, Plawgo K, Pandakov D, Philips A, Warkocki Z
Nucleic acids research 2024 Apr 12;52(6):3327-3345
Nucleic acids research 2024 Apr 12;52(6):3327-3345
Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability.
Authier F, Ondruskova N, Ferenbach AT, McNeilly AD, van Aalten DMF
Disease models & mechanisms 2024 Apr 1;17(4)
Disease models & mechanisms 2024 Apr 1;17(4)
Transcription Factor-Mediated Differentiation of Motor Neurons from Human Pluripotent Stem Cells.
Wu J, Tang Y
Methods in molecular biology (Clifton, N.J.) 2023;2593:245-258
Methods in molecular biology (Clifton, N.J.) 2023;2593:245-258
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
Liu N, Fan Y, Li Y, Zhang Y, Li J, Wang Y, Wang Z, Liu Y, Li Y, Kang Z, Peng Y, Ru Z, Yang M, Feng C, Wang Y, Yang X
Current neuropharmacology 2023;21(12):2550-2562
Current neuropharmacology 2023;21(12):2550-2562
Penfluroidol Attenuates the Imbalance of the Inflammatory Response by Repressing the Activation of the NLRP3 Inflammasome and Reduces Oxidative Stress via the Nrf2/HO-1 Signaling Pathway in LPS-Induced Macrophages.
Li Q, Wu L, Cheng B, Tao S, Wang W, Luo Z, Fan J
Mediators of inflammation 2023;2023:9940858
Mediators of inflammation 2023;2023:9940858
Pterostilbene Confers Protection against Diquat-Induced Intestinal Damage with Potential Regulation of Redox Status and Ferroptosis in Broiler Chickens.
Chen Y, Zhang H, Li Y, Wang T
Oxidative medicine and cellular longevity 2023;2023:8258354
Oxidative medicine and cellular longevity 2023;2023:8258354
Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway.
Lu Y, Zhang Y, Wang X, Zhang H, Zhu Y, Zhang J, Sha H, Zou R, Gan Y, Sui Y, Wang J, Du T, Wu J, Feng J
Disease markers 2023;2023:1702125
Disease markers 2023;2023:1702125
Caffeic acid phenethyl ester suppresses metastasis of breast cancer cells by inactivating FGFR1 via MD2.
Fang Q, Xin W, Chen L, Fu Y, Qi Y, Ding H, Fang L
PloS one 2023;18(7):e0289031
PloS one 2023;18(7):e0289031
The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies.
Li Y, Zhu S, Luo J, Tong Y, Zheng Y, Ji L, He Z, Jing Q, Huang J, Zhang Y, Bi Q
Drug design, development and therapy 2023;17:1515-1529
Drug design, development and therapy 2023;17:1515-1529
Indole-3-Aldehyde Reduces Inflammatory Responses and Restores Intestinal Epithelial Barrier Function Partially via Aryl Hydrocarbon Receptor (AhR) in Experimental Colitis Models.
Wang M, Guo J, Hart AL, Li JV
Journal of inflammation research 2023;16:5845-5864
Journal of inflammation research 2023;16:5845-5864
Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model.
Piasecki P, Wiatr K, Ruszkowski M, Marczak Ł, Trottier Y, Figiel M
Frontiers in molecular neuroscience 2023;16:1122308
Frontiers in molecular neuroscience 2023;16:1122308
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.
Yuan J, Lv T, Yang J, Wu Z, Yan L, Yang J, Shi Y, Jiang L
Cellular and molecular gastroenterology and hepatology 2023;15(2):307-325
Cellular and molecular gastroenterology and hepatology 2023;15(2):307-325
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1.
Li F, Wang L, Wang Y, Shen H, Kou Q, Shen C, Xu X, Zhang Y, Zhang J
Journal of Cancer 2023;14(15):2820-2832
Journal of Cancer 2023;14(15):2820-2832
Functional identification of two novel variants and a hypomorphic variant in ASS1 from patients with Citrullinemia type I.
Liu J, Wang Z, Yan H, Teng Y, Shi Q, Chen J, Tang W, Yu W, Peng Y, Xi H, Ma N, Liang D, Li Z, Wu L
Frontiers in genetics 2023;14:1172947
Frontiers in genetics 2023;14:1172947
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.
Chen T, Hu Y, Lu L, Zhao Q, Tao X, Ding B, Chen S, Zhu J, Guo X, Lin Z
Frontiers in pharmacology 2023;14:1134464
Frontiers in pharmacology 2023;14:1134464
The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure.
Fu Y, Xiang Y, Wang Y, Liu Z, Yang D, Zha J, Tang C, Cai J, Chen G, Dong Z
Theranostics 2023;13(9):2757-2773
Theranostics 2023;13(9):2757-2773
Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma negatively regulates telomere length.
Kliszczak M, Moralli D, Jankowska JD, Bryjka P, Subha Meem L, Goncalves T, Hester SS, Fischer R, Clynes D, Green CM
Frontiers in cell and developmental biology 2023;11:1175069
Frontiers in cell and developmental biology 2023;11:1175069
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Linear ubiquitination improves NFAT1 protein stability and facilitates NFAT1 signalling in Kawasaki disease.
Miao Y, Qian G, Zhang R, Yuan Y, Zuo Y, Ding Y, Li X, Tang Y, Zheng H, Lv H
The FEBS journal 2023 Sep;290(17):4224-4237
The FEBS journal 2023 Sep;290(17):4224-4237
Notopterol alleviates the progression of osteoarthritis: An in vitro and in vivo study.
Qu Y, Qiu L, Qiu H, Shen Y, Tang M, Huang Y, Peng Y, Wang J, Fu Q
Cytokine 2023 Sep;169:156309
Cytokine 2023 Sep;169:156309
LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
Chen D, Wang J, Li Y, Xu C, Fanzheng M, Zhang P, Liu L
Clinical and translational medicine 2023 Sep;13(9):e1418
Clinical and translational medicine 2023 Sep;13(9):e1418
The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes.
Li Y, Li H, Wang L, Xie W, Yuan D, Wen Z, Zhang T, Lai J, Xiong Z, Shan Y, Jiang W
International immunopharmacology 2023 Sep;122:110518
International immunopharmacology 2023 Sep;122:110518
African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING.
Ye G, Liu H, Liu X, Chen W, Li J, Zhao D, Wang G, Feng C, Zhang Z, Zhou Q, Zheng J, Bu Z, Weng C, Huang L
Journal of virology 2023 Sep 28;97(9):e0057723
Journal of virology 2023 Sep 28;97(9):e0057723
The African swine fever virus I10L protein inhibits the NF-κB signaling pathway by targeting IKKβ.
Chen X, Li LF, Yang ZY, Li M, Fan S, Shi LF, Ren ZY, Cao XJ, Zhang Y, Han S, Wan B, Qiu HJ, Zhang G, He WR
Journal of virology 2023 Sep 28;97(9):e0056923
Journal of virology 2023 Sep 28;97(9):e0056923
An antioxidant feedforward cycle coordinated by linker histone variant H1.2 and NRF2 that drives nonsmall cell lung cancer progression.
Chen Y, Shi J, Wang X, Zhou L, Wang Q, Xie Y, Peng C, Kuang L, Yang D, Yang J, Yang C, Li X, Yuan Y, Zhou Y, Peng A, Zhang Y, Chen H, Liu X, Zheng L, Huang K, Li Y
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 26;120(39):e2306288120
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 26;120(39):e2306288120
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement.
Zhang C, Wang H, Liu Q, Dai S, Tian G, Wei X, Li X, Zhao L, Shan B
Journal of experimental & clinical cancer research : CR 2023 Sep 23;42(1):246
Journal of experimental & clinical cancer research : CR 2023 Sep 23;42(1):246
The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.
Qiu L, Xu W, Lu X, Chen F, Chen Y, Tian Y, Zhu Q, Liu X, Wang Y, Pei XH, Xu X, Zhang J, Zhu WG
Nucleic acids research 2023 Sep 22;51(17):9166-9182
Nucleic acids research 2023 Sep 22;51(17):9166-9182
PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis.
Li S, Li L, Zhang C, Fu H, Yu S, Zhou M, Guo J, Fang Z, Li A, Zhao M, Zhang M, Wang X
eLife 2023 Sep 22;12
eLife 2023 Sep 22;12
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis.
Yan P, Li N, Ma M, Liu Z, Yang H, Li J, Wan C, Gao S, Li S, Zheng L, Waddington JL, Xu L, Zhen X
Signal transduction and targeted therapy 2023 Sep 18;8(1):355
Signal transduction and targeted therapy 2023 Sep 18;8(1):355
Follicular fluid derived exosomal miR-4449 regulates cell proliferation and oxidative stress by targeting KEAP1 in human granulosa cell lines KGN and COV434.
Wang M, Sun Y, Yuan D, Yue S, Yang Z
Experimental cell research 2023 Sep 15;430(2):113735
Experimental cell research 2023 Sep 15;430(2):113735
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics.
Mouti MA, Deng S, Pook M, Malzahn J, Rendek A, Militi S, Nibhani R, Soonawalla Z, Oppermann U, Hwang CI, Pauklin S
Nature communications 2023 Sep 14;14(1):5685
Nature communications 2023 Sep 14;14(1):5685
Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.
Yao Z, Xu N, Shang G, Wang H, Tao H, Wang Y, Qin Z, Tan S, Feng J, Zhu J, Ma F, Tian S, Zhang Q, Qu Y, Hou J, Guo J, Zhao J, Hou Y, Ding C
Nature communications 2023 Sep 13;14(1):5670
Nature communications 2023 Sep 13;14(1):5670
Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis.
Huang Y, Yang W, Yang L, Wang T, Li C, Yu J, Zhang P, Yin Y, Li R, Tao K
Scientific reports 2023 Sep 1;13(1):14359
Scientific reports 2023 Sep 1;13(1):14359
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.
Wang X, Yang J, Wang W, Li Y, Yang Y
Immunopharmacology and immunotoxicology 2023 Oct;45(5):527-538
Immunopharmacology and immunotoxicology 2023 Oct;45(5):527-538
Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells.
Bian Y, Yin G, Wang G, Liu T, Liang L, Yang X, Zhang W, Tang D
Cell biology and toxicology 2023 Oct;39(5):1957-1978
Cell biology and toxicology 2023 Oct;39(5):1957-1978
6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) Hexanol Inhibits Proliferation and Induces Apoptosis of Endometriosis by Regulating Glutathione S-Transferase Mu Class 4.
Liu W, Cheng L, Du Y, Liu X, Ma J, Yan L
Reproductive sciences (Thousand Oaks, Calif.) 2023 Oct;30(10):2945-2961
Reproductive sciences (Thousand Oaks, Calif.) 2023 Oct;30(10):2945-2961
Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation.
Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N, Xiao C, Liu WH
Cellular & molecular immunology 2023 Oct;20(10):1127-1139
Cellular & molecular immunology 2023 Oct;20(10):1127-1139
Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via a nuclear receptor (Nur77)-mediated epigenetic regulation of glutaminase 1.
Chen L, Liang B, Xia S, Wang F, Li Z, Shao J, Zhang Z, Chen A, Zheng S, Zhang F
British journal of pharmacology 2023 Oct;180(19):2577-2598
British journal of pharmacology 2023 Oct;180(19):2577-2598
D-mannose acts as a V-ATPase inhibitor to suppress inflammatory cytokines generation and bacterial killing in macrophage.
Zhao M, Chen N, Guo Y, Wu N, Cao B, Zhan B, Li Y, Zhou T, Zhu F, Guo C, Shi Y, Wang Q, Li Y, Zhang L
Molecular immunology 2023 Oct;162:84-94
Molecular immunology 2023 Oct;162:84-94
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.
Zheng C, Yu X, Xu T, Liu Z, Jiang Z, Xu J, Yang J, Zhang G, He Y, Yang H, Shi X, Li Z, Liu J, Xu WW
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4217-4233
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4217-4233
Two palladium (II) complexes derived from halogen-substituted Schiff bases and 2-picolylamine induce parthanatos-type cell death in sensitive and multi-drug resistant CCRF-CEM leukemia cells.
Zhou M, Boulos JC, Omer EA, Rudbari HA, Schirmeister T, Micale N, Efferth T
European journal of pharmacology 2023 Oct 5;956:175980
European journal of pharmacology 2023 Oct 5;956:175980
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Zhao C, Liang F, Ye M, Wu S, Qin Y, Zhao L, Zhang L, He J, Cen L, Lin F
Cell death discovery 2023 Oct 4;9(1):368
Cell death discovery 2023 Oct 4;9(1):368
Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
Guo B, Zhang S, Wang S, Zhang H, Fang J, Kang N, Zhen X, Zhang Y, Zhou J, Yan G, Sun H, Ding L, Liu C
Reproductive biology and endocrinology : RB&E 2023 Oct 31;21(1):103
Reproductive biology and endocrinology : RB&E 2023 Oct 31;21(1):103
Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain.
Kameyama T, Miyata M, Shiotani H, Adachi J, Kakuta S, Uchiyama Y, Mizutani K, Takai Y
iScience 2023 Oct 20;26(10):108010
iScience 2023 Oct 20;26(10):108010
African Swine Fever Virus pF778R Attenuates Type I Interferon Response by Impeding STAT1 Nuclear Translocation.
Chen Q, Li L, Liu L, Liu Z, Guo S, Tan C, Chen H, Wang X
Virus research 2023 Oct 2;335:199190
Virus research 2023 Oct 2;335:199190
Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456.
Wan J, Zhang Z, Wu C, Tian S, Zang Y, Jin G, Sun Q, Wang P, Luan X, Yang Y, Zhan X, Ye LL, Duan DD, Liu X, Zhang W
Signal transduction and targeted therapy 2023 Oct 19;8(1):414
Signal transduction and targeted therapy 2023 Oct 19;8(1):414
Umbilical Cord Mesenchymal-Stem-Cell-Derived Exosomes Exhibit Anti-Oxidant and Antiviral Effects as Cell-Free Therapies.
Meng Y, Li C, Liang Y, Jiang Y, Zhang H, Ouyang J, Zhang W, Deng R, Tan Q, Yu X, Luo Z
Viruses 2023 Oct 15;15(10)
Viruses 2023 Oct 15;15(10)
CSTF2 mediated mRNA N(6)-methyladenosine modification drives pancreatic ductal adenocarcinoma m(6)A subtypes.
Zheng Y, Li X, Deng S, Zhao H, Ye Y, Zhang S, Huang X, Bai R, Zhuang L, Zhou Q, Li M, Su J, Li R, Bao X, Zeng L, Chen R, Zheng J, Lin D, He C, Zhang J, Zuo Z
Nature communications 2023 Oct 10;14(1):6334
Nature communications 2023 Oct 10;14(1):6334
Diosgenin prevents dexamethasone-induced myotube atrophy in C2C12 cells.
Yoshioka Y, Oishi S, Onoda K, Shibata K, Miyoshi N
Archives of biochemistry and biophysics 2023 Oct 1;747:109759
Archives of biochemistry and biophysics 2023 Oct 1;747:109759
Stattic ameliorates the cecal ligation and puncture-induced cardiac injury in septic mice via IL-6-gp130-STAT3 signaling pathway.
Imbaby S, Hattori Y
Life sciences 2023 Oct 1;330:122008
Life sciences 2023 Oct 1;330:122008
USP39-Mediated Non-Proteolytic Control of ETS2 Suppresses Nuclear Localization and Activity.
Choi Y, Lee Y, Kim JS, Zhang P, Kim J
Biomolecules 2023 Oct 1;13(10)
Biomolecules 2023 Oct 1;13(10)
YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
Yang W, Zhang M, Li J, Qu S, Zhou F, Liu M, Li L, Liu Z, Zen K
Redox biology 2023 Nov;67:102921
Redox biology 2023 Nov;67:102921
GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
Zhou J, Xu W, Wu Y, Wang M, Zhang N, Wang L, Feng Y, Zhang T, Wang L, Mao A
Oncogene 2023 Nov;42(45):3319-3330
Oncogene 2023 Nov;42(45):3319-3330
Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway.
Xia W, Xiao J, Tong C, Lu J, Tu Y, Li S, Ni L, Shi Y, Luo P, Zhang X, Wang X
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Nov;41(11):2405-2417
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Nov;41(11):2405-2417
MiR-196b-5p activates NF-κB signaling in non-small cell lung cancer by directly targeting NFKBIA.
Zhu W, Yu Y, Ye Y, Tu X, Zhang Y, Wu T, Ni L, Huang X, Wang Y, Cui R
Translational oncology 2023 Nov;37:101755
Translational oncology 2023 Nov;37:101755
Nuclear translocation of PKM2 mediates keratinocyte metabolic reprogramming in psoriasis.
Yang L, Zhang J, Hu C, Chen X, Yang Y, Tang H, Ding X, Yan Y
Experimental dermatology 2023 Nov;32(11):1960-1970
Experimental dermatology 2023 Nov;32(11):1960-1970
Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF-κB pathway in grass carp.
Li S, Xie J, Li K, Bai Y, Jiang Z, Xiong X
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109734
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109734
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
Wang X, Wu H, An J, Zhang G, Chen Y, Fu L, Tao L, Liang G, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING-dependent therapy-induced senescence and provides "one-two punch" opportunity with anti-PD-L1 therapy in colorectal cancer.
Wang T, Liu W, Shen Q, Tao R, Li C, Shen Q, Lin Y, Huang Y, Yang L, Xie G, Bai J, Li R, Wang L, Tao K, Yin Y
Cancer science 2023 Nov;114(11):4184-4201
Cancer science 2023 Nov;114(11):4184-4201
Promotion of colorectal cancer progression by immune-related lnc-SOX9-4 via suppression of YBX1 poly-ubiquitination and degradation.
Zhao Y, Yang S, Nie H, Zhang D, Wang T, Sun Q, Wang X, Sun Y
Cellular signalling 2023 Nov;111:110854
Cellular signalling 2023 Nov;111:110854
Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy.
Cui D, Wang Z, Dang Q, Wang J, Qin J, Song J, Zhai X, Zhou Y, Zhao L, Lu G, Liu H, Liu G, Liu R, Shao C, Zhang X, Liu Z
Nature communications 2023 Nov 3;14(1):7032
Nature communications 2023 Nov 3;14(1):7032
Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells.
Li D, Ding L, Yan Y, Xing Y, Xu J, Qin L
International journal of molecular sciences 2023 Nov 28;24(23)
International journal of molecular sciences 2023 Nov 28;24(23)
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Li JJ, Dai WQ, Mo WH, Xu WQ, Li YY, Guo CY, Xu XF
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis.
Li T, Yang J, Tan A, Chen H
Diabetology & metabolic syndrome 2023 Nov 22;15(1):239
Diabetology & metabolic syndrome 2023 Nov 22;15(1):239
AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.
Zhang W, Cao L, Yang J, Zhang S, Zhao J, Shi Z, Liao K, Wang H, Chen B, Qian Z, Xu H, Wu L, Liu H, Wang H, Ma C, Qiu Y, Ge J, Chen J, Lin Y
The Journal of clinical investigation 2023 Nov 21;134(3)
The Journal of clinical investigation 2023 Nov 21;134(3)
C-X-C domain ligand 14-mediated stromal cell-macrophage interaction as a therapeutic target for hand dermal fibrosis.
Goto A, Komura S, Kato K, Maki R, Hirakawa A, Tomita H, Hirata A, Yamada Y, Akiyama H
Communications biology 2023 Nov 18;6(1):1173
Communications biology 2023 Nov 18;6(1):1173
Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant.
Mishra AP, Hartford S, Chittela RK, Sahu S, Kharat SS, Alvaro-Aranda L, Contreras-Perez A, Sullivan T, Martin BK, Albaugh M, Southon E, Burkett S, Karim B, Carreira A, Tessarollo L, Sharan SK
Cell death & disease 2023 Nov 18;14(11):753
Cell death & disease 2023 Nov 18;14(11):753
Nucleoporin93 (Nup93) Limits Yap Activity to Prevent Endothelial Cell Senescence.
Nguyen TD, Rao MK, Dhyani SP, Banks JM, Winek MA, Michalkiewicz J, Lee MY
bioRxiv : the preprint server for biology 2023 Nov 14;
bioRxiv : the preprint server for biology 2023 Nov 14;
Naringenin in Si-Ni-San formula inhibits chronic psychological stress-induced breast cancer growth and metastasis by modulating estrogen metabolism through FXR/EST pathway.
Zhang J, Wang N, Zheng Y, Yang B, Wang S, Wang X, Pan B, Wang Z
Journal of advanced research 2023 May;47:189-207
Journal of advanced research 2023 May;47:189-207
Mitochondrial transplant after ischemia reperfusion promotes cellular salvage and improves lung function during ex-vivo lung perfusion.
Cloer CM, Givens CS, Buie LK, Rochelle LK, Lin YT, Popa S, Shelton RVM, Zhan J, Zimmerman TR, Jones BG, Lesesne Z, Hogan SS, Petersen TH
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 May;42(5):575-584
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 May;42(5):575-584
Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration.
Liu L, Zhang Y, Fu J, Ai X, Long D, Leng X, Zhang Y, Huang B, Li C, Zhou Y, Feng C
Journal of orthopaedic translation 2023 May;40:116-131
Journal of orthopaedic translation 2023 May;40:116-131
eIF2α incites photoreceptor cell and retina damage by all-trans-retinal.
He D, Tao L, Cai B, Chen X, Wang Y, Li S, Liao C, Chen Y, Chen J, Liu Z, Wu Y
The Journal of biological chemistry 2023 May;299(5):104686
The Journal of biological chemistry 2023 May;299(5):104686
ER export signals mediate plasma membrane localization of transmembrane protein TMEM72.
Ding J, Matsumiya T, Miki Y, Hayakari R, Shiba Y, Kawaguchi S, Seya K, Imaizumi T
The FEBS journal 2023 May;290(10):2636-2657
The FEBS journal 2023 May;290(10):2636-2657
Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing.
Yan G, Yang J, Li W, Guo A, Guan J, Liu Y
Nature cell biology 2023 May;25(5):754-764
Nature cell biology 2023 May;25(5):754-764
Pioglitazone can improve liver sex hormone-binding globulin levels and lipid metabolism in polycystic ovary syndrome by regulating hepatocyte nuclear factor-4α.
Zhao H, Wang D, Xing C, Lv B, Wang X, He B
The Journal of steroid biochemistry and molecular biology 2023 May;229:106265
The Journal of steroid biochemistry and molecular biology 2023 May;229:106265
Periplocin targets low density lipoprotein receptor-related protein 4 to attenuate osteoclastogenesis and protect against osteoporosis.
Zhang X, Sun Z, Zhang Y, Pan L, Jiang W, Dong H, Jin Z, Kang J, Liu R, Ning B
Biochemical pharmacology 2023 May;211:115516
Biochemical pharmacology 2023 May;211:115516
C1q/tumor necrosis factor-related protein-9 exerts antioxidant and anti-inflammatory effects on oxygen-glucose deprivation/reoxygenation-stimulated neurons by modulating the Akt-GSK-3β-Nrf2 cascade via AdipoR1.
Wang J, Ren B, Yang Y, Li Y
International immunopharmacology 2023 May;118:110045
International immunopharmacology 2023 May;118:110045
Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway.
Wang X, Wang D, Deng B, Yan L
International immunopharmacology 2023 May;118:109982
International immunopharmacology 2023 May;118:109982
Targeting mTOR/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation.
Yang T, Wang Y, Cao X, Peng Y, Huang J, Chen L, Pang J, Jiang Z, Qian S, Liu Y, Ying C, Wang T, Zhang F, Lu Q, Yin X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154703
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154703
Involvement of canonical Wnt/β-catenin signaling in the extinction of auditory fear conditioning in male mice.
Xu N, Geng L, Yan X, Niu A, Yu H, Su B
Behavioural brain research 2023 May 8;445:114378
Behavioural brain research 2023 May 8;445:114378
Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling.
Hu J, Chen J, Xu X, Hou Q, Ren J, Yan X
Microbiome 2023 May 8;11(1):102
Microbiome 2023 May 8;11(1):102
HCMV Infection Reduces Nidogen-1 Expression, Contributing to Impaired Neural Rosette Development in Brain Organoids.
Ijezie EC, O'Dowd JM, Kuan MI, Faeth AR, Fortunato EA
Journal of virology 2023 May 31;97(5):e0171822
Journal of virology 2023 May 31;97(5):e0171822
Human Cytomegalovirus IE1 Impairs Neuronal Migration by Downregulating Connexin 43.
Huang SN, Pan YT, Zhou YP, Wang XZ, Mei MJ, Yang B, Li D, Zeng WB, Cheng S, Sun JY, Cheng H, Zhao F, Luo MH
Journal of virology 2023 May 31;97(5):e0031323
Journal of virology 2023 May 31;97(5):e0031323
Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines.
Kanna M, Nakatsu Y, Yamamotoya T, Kushiyama A, Fujishiro M, Sakoda H, Ono H, Arihiro K, Asano T
International journal of molecular sciences 2023 May 16;24(10)
International journal of molecular sciences 2023 May 16;24(10)
Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.
Zeng Y, Wu R, Wang F, Li S, Li L, Li Y, Qin P, Wei M, Yang J, Wu J, Chen A, Ke G, Yan Z, Yang H, Chen Z, Wang Z, Xiao W, Jiang Y, Chen X, Zeng Z, Zhao X, Chen P, Gong S
Cell host & microbe 2023 May 10;31(5):766-780.e7
Cell host & microbe 2023 May 10;31(5):766-780.e7
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Jiang H, Bai Z, Ou Y, Liu H, Si Z, Liu Y, Liu X, Liu X, Zhang Z, Tan N
Journal of ethnopharmacology 2023 May 10;307:116013
Journal of ethnopharmacology 2023 May 10;307:116013
Sivelestat sodium attenuates acute lung injury by inhibiting JNK/NF-κB and activating Nrf2/HO-1 signaling pathways.
Zhang H, Zeng J, Li J, Gong H, Chen M, Li Q, Liu S, Luo S, Dong H, Xu Y, Duan H, Haung L, Lv C
Biomolecules & biomedicine 2023 May 1;23(3):457-470
Biomolecules & biomedicine 2023 May 1;23(3):457-470
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Wang X, Jiang X, Li B, Zheng J, Guo J, Gao L, Du M, Weng X, Li L, Chen S, Zhang J, Fang L, Liu T, Wang L, Liu W, Neculai D, Sun Q
The Journal of cell biology 2023 May 1;222(5)
The Journal of cell biology 2023 May 1;222(5)
Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins.
Zhang S, Ming SL, Zeng L, Wang LF, Zhang C, Zhu HS, Yang GY, Zhang GP, Chu BB, Wang J
Journal of medical virology 2023 Mar;95(3):e28591
Journal of medical virology 2023 Mar;95(3):e28591
Promoting TFEB nuclear localization with curcumin analog C1 attenuates sensory hair cell injury and delays age-related hearing loss in C57BL/6 mice.
He W, Wu F, Xiong H, Zeng J, Gao Y, Cai Z, Pang J, Zheng Y
Neurotoxicology 2023 Mar;95:218-231
Neurotoxicology 2023 Mar;95:218-231
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Liu X, Liu Y, Chen L, Zhang Z, Cui L, Wei T
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.
Yu XM, Li SJ, Yao ZT, Xu JJ, Zheng CC, Liu ZC, Ding PB, Jiang ZL, Wei X, Zhao LP, Shi XY, Li ZG, Xu WW, Li B
Oncogene 2023 Mar;42(14):1101-1116
Oncogene 2023 Mar;42(14):1101-1116
Stabilization of nuclear β-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance.
Zuo Y, Zhan L, Wen H, Xue J, Tan Y, Sun W, Xu E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22796
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22796
Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration.
Deng Y, Peng D, Xiao J, Zhao Y, Ding W, Yuan S, Sun L, Ding J, Zhou Z, Zhan M
Cell death and differentiation 2023 Mar;30(3):702-715
Cell death and differentiation 2023 Mar;30(3):702-715
CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis.
Mo X, Shen X, Mo X, Yu F, Tan W, Deng Z, He J, Luo Z, Chen Z, Yang J
Biochemical pharmacology 2023 Mar;209:115446
Biochemical pharmacology 2023 Mar;209:115446
UVA1 irradiation attenuates collagen production via Ficz/AhR/MAPK signaling activation in scleroderma.
Shi Y, Xiao Y, Yu J, Liu J, Liu L, Ding Y, Qiu X, Zhan Y, Tang R, Zeng Z, Xiao R
International immunopharmacology 2023 Mar;116:109764
International immunopharmacology 2023 Mar;116:109764
Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.
Yang C, Lu T, Liu M, Yuan X, Li D, Zhang J, Zhou L, Xu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154668
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154668
Myb Repression Mediates Stat5b-knockdown-induced Apoptosis and Inhibits Proliferation of Glioblastoma Stem Cells.
Moyama C, Fujita M, Okamoto H, Ii H, Nakata S
Cancer genomics & proteomics 2023 Mar-Apr;20(2):195-202
Cancer genomics & proteomics 2023 Mar-Apr;20(2):195-202
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition.
Chu Q, An J, Liu P, Song Y, Zhai X, Yang R, Niu J, Yang C, Li B
The Journal of experimental medicine 2023 Mar 6;220(3)
The Journal of experimental medicine 2023 Mar 6;220(3)
BMAL1 Promotes Valvular Interstitial Cells' Osteogenic Differentiation through NF-κ B/AKT/MAPK Pathway.
Jiang Y, Wang S, Lin W, Gu J, Li G, Shao Y
Journal of cardiovascular development and disease 2023 Mar 6;10(3)
Journal of cardiovascular development and disease 2023 Mar 6;10(3)
DNAJB7 is dispensable for male fertility in mice.
Bai S, Hu M, Yu L, Chen L, Zhou J, Wu L, Xu B, Jiang X, Zhang X, Tong X, Yue Q
Reproductive biology and endocrinology : RB&E 2023 Mar 31;21(1):32
Reproductive biology and endocrinology : RB&E 2023 Mar 31;21(1):32
Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice.
Zhou Q, Zhang L, Lin Q, Liu H, Ye G, Liu X, Jiao S, Li J, Tang Y, Shi D, Huang L, Weng C
Journal of virology 2023 Mar 30;97(3):e0000323
Journal of virology 2023 Mar 30;97(3):e0000323
p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway.
Zhu X, Huang B, Zhao F, Lian J, He L, Zhang Y, Ji L, Zhang J, Yan X, Zeng T, Ma C, Liang Y, Zhang C, Lin J
Nucleic acids research 2023 Mar 21;51(5):2195-2214
Nucleic acids research 2023 Mar 21;51(5):2195-2214
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
Zhang H, Xie Z, Peng Y, Xie A, Fu C, Zheng D, Cai Z, Zhong J, Ming Q, Li M, Lu R, Liu X, Chen J
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
Arachidonic acid impairs the function of the blood-testis barrier via triggering mitochondrial complex-ROS-P38 MAPK axis in hyperthermal Sertoli cells.
Hu Y, Hu H, Yin L, Wang L, Luo K, Luo N
Ecotoxicology and environmental safety 2023 Mar 1;252:114598
Ecotoxicology and environmental safety 2023 Mar 1;252:114598
AQP8 may affect glioma proliferation and growth by regulating GSK-3β phosphorylation and nuclear transport of β-catenin.
Cai Z, Shen Z, Zhao J, Zhang H, Guo Z, Xia Q, Liang H, Liu J, Tan L, Sheng H, Zhu S
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2023 Jun;83(4):333-345
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2023 Jun;83(4):333-345
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.
Yang C, Zhao Y, Wang L, Guo Z, Ma L, Yang R, Wu Y, Li X, Niu J, Chu Q, Fu Y, Li B
Nature cell biology 2023 Jun;25(6):836-847
Nature cell biology 2023 Jun;25(6):836-847
UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.
Hu X, Zou R, Zhang Z, Ji J, Li J, Huo XY, Liu D, Ge MX, Cui MK, Wu MZ, Li ZP, Wang Q, Zhang X, Zhang ZR
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Jun;1866(2):194937
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Jun;1866(2):194937
Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure.
Piell KM, Petri BJ, Head KZ, Wahlang B, Xu R, Zhang X, Pan J, Rai SN, de Silva K, Chariker JH, Rouchka EC, Tan M, Li Y, Cave MC, Klinge CM
Environmental toxicology and pharmacology 2023 Jun;100:104138
Environmental toxicology and pharmacology 2023 Jun;100:104138
Acetylation regulates the nucleocytoplasmic distribution and oncogenic function of karyopherin alpha 2 in lung adenocarcinoma.
Feng HP, Liu YC, Wang CL, Liao WC, Yu JS, Yu CJ
Biochemical and biophysical research communications 2023 Jun 4;659:96-104
Biochemical and biophysical research communications 2023 Jun 4;659:96-104
The p23 co-chaperone is a succinate-activated COX-2 transcription factor in lung adenocarcinoma tumorigenesis.
Yu Z, Peng Y, Gao J, Zhou M, Shi L, Zhao F, Wang C, Tian X, Feng L, Huo X, Zhang B, Liu M, Fang D, Ma X
Science advances 2023 Jun 30;9(26):eade0387
Science advances 2023 Jun 30;9(26):eade0387
TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly.
Klump BM, Perez GI, Patrick EM, Adams-Boone K, Cohen SB, Han L, Yu K, Schmidt JC
Cell reports 2023 Jun 27;42(6):112577
Cell reports 2023 Jun 27;42(6):112577
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
Wang X, Wang J, Zhao X, Wu H, Li J, Cheng Y, Guo Q, Cao X, Liang T, Sun L, Zhang G
Journal of translational medicine 2023 Jun 23;21(1):407
Journal of translational medicine 2023 Jun 23;21(1):407
Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.
Cui Y, Zhang F, Xu W, Li Z, Zou J, Gao P, Hu J
BMC complementary medicine and therapies 2023 Jun 2;23(1):180
BMC complementary medicine and therapies 2023 Jun 2;23(1):180
Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges.
Miyagi T, Ueda K, Sugimoto M, Yagi T, Ito D, Yamazaki R, Narumi S, Hayamizu Y, Uji-I H, Kuroda M, Kanekura K
iScience 2023 Jun 16;26(6):106957
iScience 2023 Jun 16;26(6):106957
LncRNA ZNF593-AS alleviates diabetic cardiomyopathy via suppressing IRF3 signaling pathway.
Xie R, Fan J, Wen J, Jin K, Zhan J, Yuan S, Tang Y, Nie X, Wen Z, Li H, Chen C, Wang DW
Molecular therapy. Nucleic acids 2023 Jun 13;32:689-703
Molecular therapy. Nucleic acids 2023 Jun 13;32:689-703
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
Li C, Hao J, Qiu H, Xin H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition.
Zhang F, Gao J, Liu X, Sun Y, Liu L, Hu B, Wang Z, Shi J, Guo W, Zhang S
Molecular carcinogenesis 2023 Jul;62(7):963-974
Molecular carcinogenesis 2023 Jul;62(7):963-974
Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies.
Guo L, Mao Q, He J, Liu X, Piao X, Luo L, Hao X, Yu H, Song Q, Xiao B, Fan D, Gao Z, Jia Y
Cell research 2023 Jul;33(7):497-515
Cell research 2023 Jul;33(7):497-515
Transforming acidic coiled-coil containing protein 3 suppresses influenza A virus replication by impeding viral endosomal trafficking and nuclear import.
Deng L, Zhao L, Jin J, Qiao B, Zhang X, Chang L, Zheng L, Dankar S, Ping J
Veterinary microbiology 2023 Jul;282:109769
Veterinary microbiology 2023 Jul;282:109769
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro.
Kogami M, Abe S, Nakamura H, Aoshiba K
Oncology letters 2023 Jul;26(1):313
Oncology letters 2023 Jul;26(1):313
The mitophagy receptor NIX induces vIRF-1 oligomerization and interaction with GABARAPL1 for the promotion of HHV-8 reactivation-induced mitophagy.
Vo MT, Choi CY, Choi YB
PLoS pathogens 2023 Jul;19(7):e1011548
PLoS pathogens 2023 Jul;19(7):e1011548
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
Wu H, Liu Q, Shan X, Gao W, Chen Q
Autophagy 2023 Jul;19(7):2062-2077
Autophagy 2023 Jul;19(7):2062-2077
Upregulation of CDGSH iron sulfur domain 2 attenuates cerebral ischemia/reperfusion injury.
Hu M, Huang J, Chen L, Sun XR, Yao ZM, Tong XH, Jin WJ, Zhang YX, Dong SY
Neural regeneration research 2023 Jul;18(7):1512-1520
Neural regeneration research 2023 Jul;18(7):1512-1520
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Li X, Yu X, He S, Li J
International immunopharmacology 2023 Jul;120:110404
International immunopharmacology 2023 Jul;120:110404
Aloperine alleviates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome activation.
Zeng J, Liu J, Huang JH, Fu SP, Wang XY, Xi C, Cui YR, Qu F
International immunopharmacology 2023 Jul;120:110142
International immunopharmacology 2023 Jul;120:110142
Epigenetic plasticity safeguards heterochromatin configuration in mammals.
Fukuda K, Shimi T, Shimura C, Ono T, Suzuki T, Onoue K, Okayama S, Miura H, Hiratani I, Ikeda K, Okada Y, Dohmae N, Yonemura S, Inoue A, Kimura H, Shinkai Y
Nucleic acids research 2023 Jul 7;51(12):6190-6207
Nucleic acids research 2023 Jul 7;51(12):6190-6207
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis.
Shi J, Wang QH, Wei X, Huo B, Ye JN, Yi X, Feng X, Fang ZM, Jiang DS, Ma MJ
Molecular medicine (Cambridge, Mass.) 2023 Jul 6;29(1):91
Molecular medicine (Cambridge, Mass.) 2023 Jul 6;29(1):91
Ammonium tetrathiomolybdate relieves oxidative stress in cisplatin-induced acute kidney injury via NRF2 signaling pathway.
Qi H, Shi H, Yan M, Zhao L, Yin Y, Tan X, Qi H, Li H, Weng K, Tang Y, Dai Y
Cell death discovery 2023 Jul 25;9(1):259
Cell death discovery 2023 Jul 25;9(1):259
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
Zhang CT, Qin DL, Cao XY, Kan JS, Huang XX, Gao DS, Gao J
iScience 2023 Jul 21;26(7):107049
iScience 2023 Jul 21;26(7):107049
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
Zhao J, Xu G, Hou X, Mu W, Yang H, Shi W, Wen J, Liu T, Wu Z, Bai J, Zhang P, Wang Z, Xiao X, Zou W, Bai Z, Zhan X
Journal of ethnopharmacology 2023 Jul 15;311:116427
Journal of ethnopharmacology 2023 Jul 15;311:116427
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Zhu Y, Han Y, Wang W, Liang G, Qi J
Journal of ethnopharmacology 2023 Jul 15;311:116286
Journal of ethnopharmacology 2023 Jul 15;311:116286
Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.
Yan C, Zheng L, Jiang S, Yang H, Guo J, Jiang LY, Li T, Zhang H, Bai Y, Lou Y, Zhang Q, Liang T, Schamel W, Wang H, Yang W, Wang G, Zhu ZJ, Song BL, Xu C
Cancer cell 2023 Jul 10;41(7):1276-1293.e11
Cancer cell 2023 Jul 10;41(7):1276-1293.e11
P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases.
Zhang J, Lyu Z, Li B, You Z, Cui N, Li Y, Li Y, Huang B, Chen R, Chen Y, Peng Y, Fang J, Wang Q, Miao Q, Tang R, Gershwin ME, Lian M, Xiao X, Ma X
Hepatology (Baltimore, Md.) 2023 Jul 1;78(1):10-25
Hepatology (Baltimore, Md.) 2023 Jul 1;78(1):10-25
Dynamics and Composition of Small Heat Shock Protein Condensates and Aggregates.
Joosten J, van Sluijs B, Vree Egberts W, Emmaneel M, Jansen PWTC, Vermeulen M, Boelens W, Bonger KM, Spruijt E
Journal of molecular biology 2023 Jul 1;435(13):168139
Journal of molecular biology 2023 Jul 1;435(13):168139
Microcystin‑leucine arginine promotes colorectal cancer cell proliferation by activating the PI3K/Akt/Wnt/β‑catenin pathway.
Tang Y, Yi X, Zhang X, Liu B, Lu Y, Pan Z, Yu T, Feng W
Oncology reports 2023 Jan;49(1)
Oncology reports 2023 Jan;49(1)
VASN promotes colorectal cancer progression by activating the YAP/TAZ and AKT signaling pathways via YAP.
Liang W, Zuo J, Liu M, Su Y, Guo B, Hou J, Xing Q, Peng Y, Fang L, Cao Y, Shan J, Sun R, Zhao J, Wang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22688
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22688
Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
Qin J, Huang T, Wang Z, Zhang X, Wang J, Dang Q, Cui D, Wang X, Zhai Y, Zhao L, Lu G, Shao C, Li S, Liu H, Liu Z
Cell death and differentiation 2023 Jan;30(1):184-194
Cell death and differentiation 2023 Jan;30(1):184-194
LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion.
Jung-Garcia Y, Maiques O, Monger J, Rodriguez-Hernandez I, Fanshawe B, Domart MC, Renshaw MJ, Marti RM, Matias-Guiu X, Collinson LM, Sanz-Moreno V, Carlton JG
Nature cell biology 2023 Jan;25(1):108-119
Nature cell biology 2023 Jan;25(1):108-119
Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal.
Chen C, Yang K, He D, Yang B, Tao L, Chen J, Wu Y
Free radical biology & medicine 2023 Jan;194:245-254
Free radical biology & medicine 2023 Jan;194:245-254
A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.
Wang Y, Gao J, Yu Y, Zhou L, Wang M, Xue W, Liu B, Wu X, Wu X, Gao H, Shen Y, Xu Q
British journal of pharmacology 2023 Jan;180(2):194-213
British journal of pharmacology 2023 Jan;180(2):194-213
IKKα aggravates renal fibrogenesis by positively regulating the Wnt/β-catenin pathway.
Zhang H, Pan B, Huang W, Ma M, Zhang F, Jiang L, Qian C, Wan X, Cao C
Immunology 2023 Jan;168(1):120-134
Immunology 2023 Jan;168(1):120-134
Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways.
Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, Yu X, He J, Ge H, Liu P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:114048
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:114048
Sclareol ameliorates liver injury by inhibiting nuclear factor-kappa B/NOD-like receptor protein 3-mediated inflammation and lipid metabolism disorder in diabetic mice.
Tang L, Mei X, Ye M, Liu Y, Huang Y, Yu J, Zhang L, Zhuge S, Jiang G, Zhu J
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223644
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223644
Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB.
Meng Z, Lu J, Ge G, Wang G, Zhang R, Li Y, Guan S, Lu J
Food & function 2023 Jan 3;14(1):240-249
Food & function 2023 Jan 3;14(1):240-249
Novel Missense Variants in PAX8 and NKX2-1 Cause Congenital Hypothyroidism.
Li M, Li Z, Chen M, Hu Z, Zhou M, Wu L, Zhang C, Liang D
International journal of molecular sciences 2023 Jan 2;24(1)
International journal of molecular sciences 2023 Jan 2;24(1)
Dual functional antioxidant and butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of novel melatonin-alkylbenzylamine hybrids.
Liu P, Cheng M, Guo J, Cao D, Luo J, Wan Y, Fang Y, Jin Y, Xie SS, Liu J
Bioorganic & medicinal chemistry 2023 Jan 15;78:117146
Bioorganic & medicinal chemistry 2023 Jan 15;78:117146
The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-β pathway.
Li H, Jiang Y, Hu J, Xu J, Chen L, Zhang G, Zhao J, Zong S, Guo Z, Li X, Zhao X, Jing Z
Cell death & disease 2023 Jan 13;14(1):23
Cell death & disease 2023 Jan 13;14(1):23
DNA topoisomerase 2-associated proteins PATL1 and PATL2 regulate the biogenesis of hERG K(+) channels.
Yao L, Ruan MY, Ye SW, Cai SQ
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 10;120(2):e2206146120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 10;120(2):e2206146120
ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2.
Cao HJ, Jiang H, Ding K, Qiu XS, Ma N, Zhang FK, Wang YK, Zheng QW, Xia J, Ni QZ, Xu S, Zhu B, Ding XF, Chen TW, Qiu L, Chen W, Li ZG, Zhou B, Feng WM, Xie D, Li JJ
Cell death and differentiation 2023 Feb;30(2):383-396
Cell death and differentiation 2023 Feb;30(2):383-396
Trans-anethole exerts protective effects on lipopolysaccharide-induced acute jejunal inflammation of broilers via repressing NF-κB signaling pathway.
Tong Y, Yu C, Chen S, Zhang X, Yang Z, Wang T
Poultry science 2023 Feb;102(2):102397
Poultry science 2023 Feb;102(2):102397
Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading.
Zhang L, Xu L, Wang Y, Zhang X, Xue T, Sun Q, Tang H, Li M, Cao X, Shi F, Zhang G, Zhang S, Hu Z
Cellular signalling 2023 Feb;102:110554
Cellular signalling 2023 Feb;102:110554
Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway.
Pang Y, Zhao L, Ji X, Guo K, Yin X
Molecules (Basel, Switzerland) 2023 Feb 7;28(4)
Molecules (Basel, Switzerland) 2023 Feb 7;28(4)
The hnRNP C tetramer binds to CBC on mRNA and impedes PHAX recruitment for the classification of RNA polymerase II transcripts.
Dantsuji S, Ohno M, Taniguchi I
Nucleic acids research 2023 Feb 22;51(3):1393-1408
Nucleic acids research 2023 Feb 22;51(3):1393-1408
Cytosolic Release of Mitochondrial DNA and Associated cGAS Signaling Mediates Radiation-Induced Hematopoietic Injury of Mice.
Guan H, Zhang W, Xie D, Nie Y, Chen S, Sun X, Zhao H, Liu X, Wang H, Huang X, Bai C, Huang B, Zhou P, Gao S
International journal of molecular sciences 2023 Feb 16;24(4)
International journal of molecular sciences 2023 Feb 16;24(4)
HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity.
Yuan B, Liu J, Shi A, Cao J, Yu Y, Zhu Y, Zhang C, Qiu Y, Luo H, Shi J, Cao X, Xu P, Shen L, Liang T, Zhao B, Feng XH
The EMBO journal 2023 Feb 15;42(4):e111549
The EMBO journal 2023 Feb 15;42(4):e111549
Identification and validation of microtubule depolymerizing agent, CYT997, as a potential drug candidate for hepatocellular carcinoma.
Ahmad F, Ma L, Wei W, Liu Y, Hakim I, Daugherty A, Mujahid S, Radin AA, Chua MS, So S
Liver international : official journal of the International Association for the Study of the Liver 2023 Dec;43(12):2794-2807
Liver international : official journal of the International Association for the Study of the Liver 2023 Dec;43(12):2794-2807
20-Deoxyingenol alleviates intervertebral disc degeneration by activating TFEB in nucleus pulposus cells.
Chen Y, Wu C, Zhao X, Tan H, Li C, Deng Y, Chen X, Wu Y, Tian N, Zhang X, Zhou Y, Sun L
Biochemical pharmacology 2023 Dec;218:115865
Biochemical pharmacology 2023 Dec;218:115865
Scribble promotes fibrosis-dependent mechanisms of hepatocarcinogenesis by p53/PUMA-mediated glycolysis.
Wu Y, Song L, Kong J, Wen Q, Jiao J, Wang X, Li G, Xu X, Zhan L
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166823
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166823
Chemical constituents from Eupatorium fortunei and their anti-inflammatory evaluation by in silico and experimental approaches.
Miao L, Wei QH, Wang ST, Sun P, Zhang H
Fitoterapia 2023 Dec;171:105700
Fitoterapia 2023 Dec;171:105700
USP7 promotes non-small-cell lung cancer cell glycolysis and survival by stabilizing and activating c-Abl.
He Y, Jiang S, Zhong Y, Wang X, Cui Y, Liang J, Sun Y, Zhu Z, Huang Z, Mao X
Clinical and translational medicine 2023 Dec;13(12):e1509
Clinical and translational medicine 2023 Dec;13(12):e1509
PGC1α deficiency reverses cholestasis-induced liver injury via attenuating hepatic inflammation and promoting bile duct remodeling.
Li D, Ye C, Liu P, Sun T, Qin Y, Wan X
Acta histochemica 2023 Dec;125(8):152097
Acta histochemica 2023 Dec;125(8):152097
Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc.
Bi X, Zhang M, Zhou J, Yan X, Cheng L, Luo L, Huang C, Yin Z
Cellular signalling 2023 Dec;112:110913
Cellular signalling 2023 Dec;112:110913
Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion.
White MJ, Jacobs KA, Singh T, Mayo LN, Lin A, Chen CS, Jun YW, Kutys ML
The Journal of cell biology 2023 Dec 4;222(12)
The Journal of cell biology 2023 Dec 4;222(12)
A20 ameliorates Aspergillus fumigatus keratitis by promoting autophagy and inhibiting NF-κB signaling.
Han F, Wang L, Shen L, Liu W, Li Y, Ma H, Wu X
International journal of biological macromolecules 2023 Dec 31;253(Pt 8):127640
International journal of biological macromolecules 2023 Dec 31;253(Pt 8):127640
Ubiquitination-dependent degradation of nucleolin mediated by porcine circovirus type 3 capsid protein.
Wang D, Hou L, Ji Y, Xie J, Zhao J, Zhu N, Yang X, Zhou J, Cui Y, Guo J, Feng X, Liu J
Journal of virology 2023 Dec 21;97(12):e0089423
Journal of virology 2023 Dec 21;97(12):e0089423
Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages.
Feng P, Che Y, Gao C, Chu X, Li Z, Li L, Li J, Gao J, Dong Y
iScience 2023 Dec 15;26(12):108484
iScience 2023 Dec 15;26(12):108484
NDRG3 regulates imatinib resistance by promoting β‑catenin accumulation in the nucleus in chronic myelogenous leukemia.
Wang X, Rong S, Sun Y, Yin B, Yang X, Lu X, Sun H, Yan Y, Sun G, Liang Y, Wang P, Xie S, Li Y
Oncology reports 2023 Aug;50(2)
Oncology reports 2023 Aug;50(2)
The MGF300-2R protein of African swine fever virus is associated with viral pathogenicity by promoting the autophagic degradation of IKKα and IKKβ through the recruitment of TOLLIP.
Wang T, Luo R, Zhang J, Lu Z, Li LF, Zheng YH, Pan L, Lan J, Zhai H, Huang S, Sun Y, Qiu HJ
PLoS pathogens 2023 Aug;19(8):e1011580
PLoS pathogens 2023 Aug;19(8):e1011580
NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1(G93A) mutation and exerts neuroprotection in amyotrophic lateral sclerosis.
Yang B, Pan J, Zhang XN, Wang H, He L, Rong X, Li X, Peng Y
Neurobiology of disease 2023 Aug;184:106210
Neurobiology of disease 2023 Aug;184:106210
RNF4 and USP7 cooperate in ubiquitin-regulated steps of DNA replication.
Chang YC, Lin K, Baxley RM, Durrett W, Wang L, Stojkova O, Billmann M, Ward H, Myers CL, Bielinsky AK
Open biology 2023 Aug;13(8):230068
Open biology 2023 Aug;13(8):230068
Sculponeatin A promotes the ETS1-SYVN1 interaction to induce SLC7A11/xCT-dependent ferroptosis in breast cancer.
Peng P, Ren Y, Wan F, Tan M, Wu H, Shen J, Qian C, Liu X, Xiang Y, Yu Q, Zhang L, Si Y, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154921
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154921
Curcumin Alleviates Singapore Grouper Iridovirus-Induced Intestine Injury in Orange-Spotted Grouper (Epinephelus coioides).
Wang YX, Xu SF, Wang YW, Jiang YX, Qin QW, Wei SN
Antioxidants (Basel, Switzerland) 2023 Aug 9;12(8)
Antioxidants (Basel, Switzerland) 2023 Aug 9;12(8)
Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition.
Li X, Sung P, Zhang D, Yan L
Physiological research 2023 Aug 31;72(4):497-510
Physiological research 2023 Aug 31;72(4):497-510
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner.
Shi M, Hou J, Liang W, Li Q, Shao S, Ci S, Shu C, Zhao X, Zhao S, Huang M, Wu C, Hu Z, He L, Guo Z, Pan F
EMBO reports 2023 Aug 3;24(8):e56437
EMBO reports 2023 Aug 3;24(8):e56437
Subcellular localization shapes the fate of RNA polymerase III.
Tian K, Wang R, Huang J, Wang H, Ji X
Cell reports 2023 Aug 29;42(8):112941
Cell reports 2023 Aug 29;42(8):112941
Boron-Doped Carbon Nanodots as a Theranostic Agent for Colon Cancer Stem Cells.
Ozkasapoglu S, Caglayan MG, Akkurt F, Ensarioğlu HK, Vatansever HS, Celikkan H
ACS omega 2023 Aug 22;8(33):30285-30293
ACS omega 2023 Aug 22;8(33):30285-30293
NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways.
Meng L, Lu Y, Wang X, Cheng C, Xue F, Xie L, Zhang Y, Sui W, Zhang M, Zhang Y, Zhang C
Science advances 2023 Aug 2;9(31):eadd4222
Science advances 2023 Aug 2;9(31):eadd4222
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
Liu Y, Sun Q, Zhang C, Ding M, Wang C, Zheng Q, Ma Z, Xu H, Zhou G, Wang X, Cheng Z, Xia H
iScience 2023 Aug 18;26(8):107376
iScience 2023 Aug 18;26(8):107376
MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/β-catenin signaling pathway through autophagy.
Zhang H, Shen S, Feng C, Chen G, Wang X
Acta biochimica et biophysica Sinica 2023 Aug 17;55(9):1445-1455
Acta biochimica et biophysica Sinica 2023 Aug 17;55(9):1445-1455
Nuclear damage in LMNA mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope.
Wallace M, Zahr H, Perati S, Morsink CD, Johnson LE, Gacita AM, Lai S, Wallrath LL, Benjamin IJ, McNally EM, Kirby TJ, Lammerding J
Molecular biology of the cell 2023 Aug 16;34(12):mbcE21100527
Molecular biology of the cell 2023 Aug 16;34(12):mbcE21100527
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Gao Z, Zhan H, Zong W, Sun M, Linghu L, Wang G, Meng F, Chen M
Life sciences 2023 Aug 15;327:121793
Life sciences 2023 Aug 15;327:121793
Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner.
Chen Y, Zhu S, Lin Z, Zhang Y, Jin C, He S, Chen X, Zhou X
Molecular biology reports 2023 Apr;50(4):3469-3478
Molecular biology reports 2023 Apr;50(4):3469-3478
Atractylenolide III suppresses senescence-associated secretome via inhibiting cGAS/NF-κB pathway in hepatic stellate cells.
Wu H, Wu L, Xiao L, Gu Y, Liu H, Zhang L, Zhang M, Qi L
Clinical and experimental pharmacology & physiology 2023 Apr;50(4):316-324
Clinical and experimental pharmacology & physiology 2023 Apr;50(4):316-324
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus.
An D, Qi X, Li K, Xu W, Wang Y, Chen X, Sha S, Wu C, Du Y, Chen L
Cellular and molecular neurobiology 2023 Apr;43(3):1283-1300
Cellular and molecular neurobiology 2023 Apr;43(3):1283-1300
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases.
Yarnall MTN, Ioannidi EI, Schmitt-Ulms C, Krajeski RN, Lim J, Villiger L, Zhou W, Jiang K, Garushyants SK, Roberts N, Zhang L, Vakulskas CA, Walker JA 2nd, Kadina AP, Zepeda AE, Holden K, Ma H, Xie J, Gao G, Foquet L, Bial G, Donnelly SK, Miyata Y, Radiloff DR, Henderson JM, Ujita A, Abudayyeh OO, Gootenberg JS
Nature biotechnology 2023 Apr;41(4):500-512
Nature biotechnology 2023 Apr;41(4):500-512
ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.
Zhang Q, Liu S, Wang H, Xiao K, Lu J, Chen S, Huang M, Xie R, Lin T, Chen X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205613
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205613
Multi-omics and network pharmacology study reveals the effects of Dengzhan Shengmai capsule against neuroinflammatory injury and thrombosis induced by ischemic stroke.
Ye J, Huang F, Zeng H, Xu X, Wu G, Tian S, Zhao J, Zhang W
Journal of ethnopharmacology 2023 Apr 6;305:116092
Journal of ethnopharmacology 2023 Apr 6;305:116092
Effects of Sepsis Serum on the Fate of Adipose Tissue-Derived Stem Cells.
Fang J, Lu R, Lin Y, Wang H, Wei H, Wang J, Liu Q, Liu H, Zhou Z, Zhang L, Pan R, Chen Y
Frontiers in bioscience (Landmark edition) 2023 Apr 6;28(4):72
Frontiers in bioscience (Landmark edition) 2023 Apr 6;28(4):72
SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
Zheng G, Su Y, Wei L, Yao Y, Wang Y, Luo X, Wang X, Ruan XZ, Li D, Chen Y
Cell death & disease 2023 Apr 6;14(4):249
Cell death & disease 2023 Apr 6;14(4):249
Mechanisms Underlying the Suppression of IL-1β Expression by Magnesium Hydroxide Nanoparticles.
Koga A, Thongsiri C, Kudo D, Phuong DND, Iwamoto Y, Fujii W, Nagai-Yoshioka Y, Yamasaki R, Ariyoshi W
Biomedicines 2023 Apr 27;11(5)
Biomedicines 2023 Apr 27;11(5)
ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response.
Liu Y, Zhang L, Zhang S, Liu J, Li X, Yang K, Yang D, Liu Y, Sun L, Liu F, Xiao L
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):57
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):57
Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling.
Chen Y, Cui T, Xiao S, Li T, Zhong Y, Tang K, Guo J, Huang S, Chen J, Li J, Wang Q, Huang J, Pan H, Gao Y
iScience 2023 Apr 21;26(4):106318
iScience 2023 Apr 21;26(4):106318
IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity.
Wang Z, Sun P, Pan B, Qiu J, Zhang X, Shen S, Ke X, Tang N
Cell communication and signaling : CCS 2023 Apr 20;21(1):80
Cell communication and signaling : CCS 2023 Apr 20;21(1):80
SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction.
Nie Y, Mou L, Long Q, Deng D, Hu R, Cheng J, Wu J
Virus research 2023 Apr 15;328:199086
Virus research 2023 Apr 15;328:199086
Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway.
Huang X, Kou X, Zhan T, Wei G, He F, Mao X, Yang H
Stem cell research & therapy 2023 Apr 15;14(1):88
Stem cell research & therapy 2023 Apr 15;14(1):88
Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H(2)O(2)-induced liver injury in HepG2 cells.
Li X, Hua Y, Yang C, Liu S, Tan L, Guo J, Li Y
BMC complementary medicine and therapies 2023 Apr 12;23(1):112
BMC complementary medicine and therapies 2023 Apr 12;23(1):112
Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway.
Zhang Y, Zhu Z, Sun L, Yin W, Liang Y, Chen H, Bi Y, Zhai W, Yin Y, Zhang W
Nutrients 2023 Apr 11;15(8)
Nutrients 2023 Apr 11;15(8)
Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease.
Wang D, Yin L, Chen R, Tan W, Liang L, Xiang J, Zhang H, Zhou X, Deng H, Guo B, Wang Y
Frontiers in medicine 2022;9:1018298
Frontiers in medicine 2022;9:1018298
Effect of Lycium barbarum Polysaccharide on Decreasing Serum Amyloid A3 Expression through Inhibiting NF-κB Activation in a Mouse Model of Diabetic Nephropathy.
Wan F, Ma F, Wu J, Qiao X, Chen M, Li W, Ma L
Analytical cellular pathology (Amsterdam) 2022;2022:7847135
Analytical cellular pathology (Amsterdam) 2022;2022:7847135
TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway.
Cui H, Zhang L, Chen B, Zhang F, Xu H, Ma G, Cao L, Wang M
Contrast media & molecular imaging 2022;2022:5697034
Contrast media & molecular imaging 2022;2022:5697034
Dopamine Suppresses Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells via AKT/GSK-3β/β-Catenin Signaling Pathway.
Kuang Z, Chen Z, Tu S, Mai Z, Chen L, Kang X, Chen X, Wei J, Wang Y, Peng Y, Ai H
Stem cells international 2022;2022:4154440
Stem cells international 2022;2022:4154440
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway.
Wu X, Wei S, Chen M, Li J, Wei Y, Zhang J, Dong W
International journal of biological sciences 2022;18(13):5056-5069
International journal of biological sciences 2022;18(13):5056-5069
Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption of the Nuclear Lamina, TDP-43 Mislocalization and Cell Death.
Candia RF, Cohen LS, Morozova V, Corbo C, Alonso AD
Frontiers in molecular neuroscience 2022;15:888420
Frontiers in molecular neuroscience 2022;15:888420
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway.
Huang X, Yao Y, Hou X, Wei L, Rao Y, Su Y, Zheng G, Ruan XZ, Li D, Chen Y
Cellular and molecular gastroenterology and hepatology 2022;14(1):1-26
Cellular and molecular gastroenterology and hepatology 2022;14(1):1-26
Pitx3 deficiency promotes age-dependent alterations in striatal medium spiny neurons.
Chen X, Yang Z, Shao Y, Kim K, Wang Y, Wang Y, Wu H, Xu X, Le W
Frontiers in aging neuroscience 2022;14:960479
Frontiers in aging neuroscience 2022;14:960479
Selective targeting of MD2 attenuates intestinal inflammation and prevents neonatal necrotizing enterocolitis by suppressing TLR4 signaling.
Huang D, Wang P, Chen J, Li Y, Zhu M, Tang Y, Zhou W
Frontiers in immunology 2022;13:995791
Frontiers in immunology 2022;13:995791
MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation.
Liu M, Peng Y, Che Y, Zhou M, Bai Y, Tang W, Huang S, Zhang B, Deng S, Wang C, Yu Z
Frontiers in pharmacology 2022;13:978587
Frontiers in pharmacology 2022;13:978587
Phosphatidylethanolamine-binding protein 4 deficiency exacerbates carbon tetrachloride-induced liver fibrosis by regulating the NF-κB signaling pathway.
Luo Q, Ling Y, Li Y, Qu X, Shi Q, Zheng S, Li Y, Huang Y, Zhou X
Frontiers in pharmacology 2022;13:964829
Frontiers in pharmacology 2022;13:964829
Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway.
Li L, Deng S, Liu M, Yang M, Li J, Liu T, Zhang T, Zhao Y, He M, Wu D, Xu Y
Frontiers in pharmacology 2022;13:956402
Frontiers in pharmacology 2022;13:956402
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
Jiang Z, Qi G, Lu W, Wang H, Li D, Chen W, Ding L, Yang X, Yuan H, Zeng Q
Frontiers in pharmacology 2022;13:952950
Frontiers in pharmacology 2022;13:952950
The miR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance via the regulation of the TGF-β signal pathway.
Li X, Gao X, Yuan J, Wang F, Xu X, Wang C, Liu H, Guan W, Zhang J, Xu G
Frontiers in endocrinology 2022;13:950345
Frontiers in endocrinology 2022;13:950345
The Antigastric Cancer Effect of Triptolide is Associated With H19/NF-κB/FLIP Axis.
Yuan W, Huang J, Hou S, Li H, Bie L, Chen B, Li G, Zhou Y, Chen X
Frontiers in pharmacology 2022;13:918588
Frontiers in pharmacology 2022;13:918588
Baicalein Prevents Fructose-Induced Hepatic Steatosis in Rats: In the Regulation of Fatty Acid De Novo Synthesis, Fatty Acid Elongation and Fatty Acid Oxidation.
Li P, Zhang R, Wang M, Chen Y, Chen Z, Ke X, Zuo L, Wang J
Frontiers in pharmacology 2022;13:917329
Frontiers in pharmacology 2022;13:917329
Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα-NF-κB p65 Complex.
Chen J, Song D, Xu Y, Wu L, Tang L, Su Y, Xie X, Zhao J, Xu J, Liu Q
Frontiers in pharmacology 2022;13:896108
Frontiers in pharmacology 2022;13:896108
TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma.
Shi B, Hao Y, Li W, Dong H, Xu M, Gao P
Frontiers in immunology 2022;13:883885
Frontiers in immunology 2022;13:883885
Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway.
Hu X, Li C, Wang Q, Wei Z, Chen T, Wang Y, Li Y
Frontiers in pharmacology 2022;13:872057
Frontiers in pharmacology 2022;13:872057
Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells.
Morikawa S, Blacher L, Onwumere C, Urano F
Frontiers in endocrinology 2022;13:849204
Frontiers in endocrinology 2022;13:849204
Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway.
Xu Z, Zhang M, Wang Y, Chen R, Xu S, Sun X, Yang Y, Lin Z, Wang S, Huang H
Frontiers in pharmacology 2022;13:848915
Frontiers in pharmacology 2022;13:848915
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion.
Tang L, Li T, Zhang B, Zhang Z, Sun X, Zhu Y, Feng B, Su Z, Yang L, Li H, Liu H, Chen Y, Dai Z, Zheng X, Li M, Li C, Zhao J, Qiu X, Ye S, Liu H, Zheng G, Li B, Lu C
Frontiers in pharmacology 2022;13:817526
Frontiers in pharmacology 2022;13:817526
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Liang S, Zhu C, Suo C, Wei H, Yu Y, Gu X, Chen L, Yuan M, Shen S, Li S, Sun L, Gao P
Frontiers in oncology 2022;12:857968
Frontiers in oncology 2022;12:857968
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Liu H, Zhao L, Wang M, Yang K, Jin Z, Zhao C, Shi G
Frontiers in oncology 2022;12:852095
Frontiers in oncology 2022;12:852095
Theaflavin Attenuates TBHP-Induced Endothelial Cells Oxidative Stress by Activating PI3K/AKT/Nrf2 and Accelerates Wound Healing in Rats.
Chen D, Wu Z, Wu LN, Jiang J, Hu GN
Frontiers in bioengineering and biotechnology 2022;10:830574
Frontiers in bioengineering and biotechnology 2022;10:830574
miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.
Hayashi C, Fukuda T, Kawakami K, Toyoda M, Nakao Y, Watanabe Y, Shinjo T, Sano T, Iwashita M, Yotsumoto K, Shida M, Taketomi T, Sanui T, Uchiumi T, Kanematsu T, Nishimura F
Frontiers in cell and developmental biology 2022;10:1061216
Frontiers in cell and developmental biology 2022;10:1061216
IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells.
Zhu Y, Chen S, Liu W, Xu F, Lu J, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Connective tissue research 2022 Sep;63(5):498-513
Connective tissue research 2022 Sep;63(5):498-513
Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.
Bell ES, Shah P, Zuela-Sopilniak N, Kim D, Varlet AA, Morival JLP, McGregor AL, Isermann P, Davidson PM, Elacqua JJ, Lakins JN, Vahdat L, Weaver VM, Smolka MB, Span PN, Lammerding J
Oncogene 2022 Sep;41(36):4211-4230
Oncogene 2022 Sep;41(36):4211-4230
PGM3 regulates beta-catenin activity to promote colorectal cancer cell progression.
Zhang N, Liu S, Xu J, Ning T, Xie S, Min L, Zhu S, Zhang S, Zhu S
Experimental biology and medicine (Maywood, N.J.) 2022 Sep;247(17):1518-1528
Experimental biology and medicine (Maywood, N.J.) 2022 Sep;247(17):1518-1528
Induction of ferroptosis selectively eliminates senescent tubular cells.
Liao CM, Wulfmeyer VC, Chen R, Erlangga Z, Sinning J, von Mässenhausen A, Sörensen-Zender I, Beer K, von Vietinghoff S, Haller H, Linkermann A, Melk A, Schmitt R
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2022 Sep;22(9):2158-2168
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2022 Sep;22(9):2158-2168
Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection.
Xi J, Zhang Z, Wang Z, Wu Q, He Y, Xu Y, Ding Z, Zhao H, Da H, Zhang F, Zhao H, Fang J
Free radical biology & medicine 2022 Sep;190:202-215
Free radical biology & medicine 2022 Sep;190:202-215
Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis.
Gao Y, Ma K, Kang Y, Liu W, Liu X, Long X, Hayashi T, Hattori S, Mizuno K, Fujisaki H, Ikejima T
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Sep;1867(9):159181
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Sep;1867(9):159181
Phosphorylation of Ser82 on IRF3 acts as negative-feedback regulation of IRF3-dependent innate immunity.
Cheng Q, Yuan L, Guo J, Guo D, Liu X, Li S
The international journal of biochemistry & cell biology 2022 Sep;150:106275
The international journal of biochemistry & cell biology 2022 Sep;150:106275
The pH sensor and ion binding of NhaD Na(+) /H(+) antiporter from IT superfamily.
Lv P, Li Y, Wang R, Zhang Y, Wang W, Liu Y, Shang Y, Su D, Wang W, Yang C
Molecular microbiology 2022 Sep;118(3):244-257
Molecular microbiology 2022 Sep;118(3):244-257
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Shen Y, Fan X, Qu Y, Tang M, Huang Y, Peng Y, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Li L, Zhu G, Fu G, Zha W, Li H
International journal of molecular sciences 2022 Sep 9;23(18)
International journal of molecular sciences 2022 Sep 9;23(18)
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
Wang ZC, Niu KM, Wu YJ, Du KR, Qi LW, Zhou YB, Sun HJ
Cell death & disease 2022 Sep 26;13(9):824
Cell death & disease 2022 Sep 26;13(9):824
An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms.
Yao H, Song W, Cao R, Ye C, Zhang L, Chen H, Wang J, Shi Y, Li R, Li Y, Liu X, Zhou X, Shao R, Li L
Nature communications 2022 Sep 20;13(1):5506
Nature communications 2022 Sep 20;13(1):5506
African Swine Fever Virus pI215L Inhibits Type I Interferon Signaling by Targeting Interferon Regulatory Factor 9 for Autophagic Degradation.
Li L, Fu J, Li J, Guo S, Chen Q, Zhang Y, Liu Z, Tan C, Chen H, Wang X
Journal of virology 2022 Sep 14;96(17):e0094422
Journal of virology 2022 Sep 14;96(17):e0094422
Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways.
Zhao L, Zheng L, Li Z, Jin M, Wang Q, Cheng J, Li J, Feng H
Aging 2022 Sep 1;14(17):6993-7002
Aging 2022 Sep 1;14(17):6993-7002
Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses.
Yan J, Chen Y, Patel AJ, Warda S, Lee CJ, Nixon BG, Wong EW, Miranda-Román MA, Yang N, Wang Y, Pachai MR, Sher J, Giff E, Tang F, Khurana E, Singer S, Liu Y, Galbo PM Jr, Maag JL, Koche RP, Zheng D, Antonescu CR, Deng L, Li MO, Chen Y, Chi P
The Journal of clinical investigation 2022 Sep 1;132(17)
The Journal of clinical investigation 2022 Sep 1;132(17)
A Novel lncRNA Mediates the Delayed Tooth Eruption of Cleidocranial Dysplasia.
Xin Y, Liu Y, Li J, Liu D, Zhang C, Wang Y, Zheng S
Cells 2022 Sep 1;11(17)
Cells 2022 Sep 1;11(17)
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
Chen TY, Zheng SK
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.
Ren X, Yu J, Guo L, Zhang Z
Metabolic brain disease 2022 Oct;37(7):2417-2429
Metabolic brain disease 2022 Oct;37(7):2417-2429
Schisandra chinensis (Turcz.) Baill. essential oil exhibits antidepressant-like effects and against brain oxidative stress through Nrf2/HO-1 pathway activation.
Tan L, Yang Y, Peng J, Zhang Y, Wu B, He B, Jia Y, Yan T
Metabolic brain disease 2022 Oct;37(7):2261-2275
Metabolic brain disease 2022 Oct;37(7):2261-2275
1,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes.
Guan S, Zhang R, Zhao Y, Meng Z, Lu J
Environmental toxicology 2022 Oct;37(10):2515-2528
Environmental toxicology 2022 Oct;37(10):2515-2528
Cold exposure-induced endoplasmic reticulum stress regulates autophagy through the SIRT2/FoxO1 signaling pathway.
Guo J, Nie J, Chen Z, Wang X, Hu H, Xu J, Lu J, Ma L, Ji H, Yuan J, Xu B
Journal of cellular physiology 2022 Oct;237(10):3960-3970
Journal of cellular physiology 2022 Oct;237(10):3960-3970
Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway.
Zhao K, Jiang Y, Zhang J, Shi J, Zheng P, Yang C, Chen Y
Cell cycle (Georgetown, Tex.) 2022 Oct;21(19):2091-2108
Cell cycle (Georgetown, Tex.) 2022 Oct;21(19):2091-2108
Skin chronological aging drives age-related bone loss via secretion of cystatin-A.
Liang W, Chen Q, Cheng S, Wei R, Li Y, Yao C, Ouyang Z, Kang D, Chen A, Liu Z, Li K, Bai X, Li Q, Huang B
Nature aging 2022 Oct;2(10):906-922
Nature aging 2022 Oct;2(10):906-922
Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin α7 is counteracted by TBK1-p62 axis-mediated autophagy.
Wang X, Jiang L, Wang G, Shi W, Hu Y, Wang B, Zeng X, Tian G, Deng G, Shi J, Liu L, Li C, Chen H
Cellular & molecular immunology 2022 Oct;19(10):1168-1184
Cellular & molecular immunology 2022 Oct;19(10):1168-1184
LncRNA LINC00281/Annexin A2 Regulates Vascular Smooth Muscle Cell Phenotype Switching via the Nuclear Factor-Kappa B Signaling Pathway.
Cheng L, Wang H, Maboh R, Mao G, Wu X, Chen H
Journal of cardiovascular translational research 2022 Oct;15(5):971-984
Journal of cardiovascular translational research 2022 Oct;15(5):971-984
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939
Bioorganic chemistry 2022 Oct;127:105939
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.
Pan Z, Xu T, Bao L, Hu X, Jin T, Chen J, Chen J, Qian Y, Lu X, Li L, Zheng G, Zhang Y, Zou X, Song F, Zheng C, Jiang L, Wang J, Tan Z, Huang P, Ge M
Molecular cancer 2022 Oct 3;21(1):190
Molecular cancer 2022 Oct 3;21(1):190
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
Wen P, Wang H, Li Y, Sui X, Hou Z, Guo X, Xue W, Liu D, Wang Y, Gao J
Cell communication and signaling : CCS 2022 Oct 28;20(1):170
Cell communication and signaling : CCS 2022 Oct 28;20(1):170
Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1.
Kuan MI, Caruso LB, Zavala AG, Rana PSJB, O'Dowd JM, Tempera I, Fortunato EA
Journal of virology 2022 Oct 26;96(20):e0133622
Journal of virology 2022 Oct 26;96(20):e0133622
Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.
Chen Y, Zhang H, Li Y, Ji S, Jia P, Wang T
Journal of agricultural and food chemistry 2022 Oct 26;70(42):13661-13675
Journal of agricultural and food chemistry 2022 Oct 26;70(42):13661-13675
Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response.
Yang YL, Cao LB, He WR, Zhong L, Guo Y, Yang Q, Shu HB, Hu MM
Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 25;119(43):e2207280119
Proceedings of the National Academy of Sciences of the United States of America 2022 Oct 25;119(43):e2207280119
Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice.
Sanz-Ros J, Romero-García N, Mas-Bargues C, Monleón D, Gordevicius J, Brooke RT, Dromant M, Díaz A, Derevyanko A, Guío-Carrión A, Román-Domínguez A, Inglés M, Blasco MA, Horvath S, Viña J, Borrás C
Science advances 2022 Oct 21;8(42):eabq2226
Science advances 2022 Oct 21;8(42):eabq2226
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
Zhan Y, Zhang Z, Liu Y, Fang Y, Xie Y, Zheng Y, Li G, Liang L, Ding Y
BMC medicine 2022 Oct 19;20(1):365
BMC medicine 2022 Oct 19;20(1):365
splitSMLM, a spectral demixing method for high-precision multi-color localization microscopy applied to nuclear pore complexes.
Andronov L, Genthial R, Hentsch D, Klaholz BP
Communications biology 2022 Oct 17;5(1):1100
Communications biology 2022 Oct 17;5(1):1100
Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway.
Yan J, Honglei Y, Yun W, Sheng D, Yun H, Anhua Z, Na F, Min L, Dandan S, Jing W, Junming T, Wenjun Z, Xiju H
European journal of pharmacology 2022 Oct 15;933:175254
European journal of pharmacology 2022 Oct 15;933:175254
Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells.
Zhao Y, Zhang R, Wang Z, Chen Z, Wang G, Guan S, Lu J
Journal of agricultural and food chemistry 2022 Oct 12;70(40):12953-12967
Journal of agricultural and food chemistry 2022 Oct 12;70(40):12953-12967
OL-FS13 alleviates experimental cerebral ischemia-reperfusion injury.
Liu N, Li Y, Yang Y, Shu L, Liu Y, Wu Y, Sun D, Kang Z, Zhang Y, Ni D, Wei Z, Li S, Yang M, Wang Y, Sun J, Yang X
Experimental neurology 2022 Nov;357:114180
Experimental neurology 2022 Nov;357:114180
African swine fever virus pE301R negatively regulates cGAS-STING signaling pathway by inhibiting the nuclear translocation of IRF3.
Liu X, Liu H, Ye G, Xue M, Yu H, Feng C, Zhou Q, Liu X, Zhang L, Jiao S, Weng C, Huang L
Veterinary microbiology 2022 Nov;274:109556
Veterinary microbiology 2022 Nov;274:109556
Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.
Zhu Y, Yang Y, Bu H, Huang H, Chen H, Ran J, Qin L, Ni Y, Yao M, Song T, Li M, Yang Y, Guo T, Chao N, Liu Z, Li W, Zhang L
Cancer science 2022 Nov;113(11):3722-3734
Cancer science 2022 Nov;113(11):3722-3734
Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease.
Pan Z, Guo J, Tang K, Chen Y, Gong X, Chen Y, Zhong Y, Xiao X, Duan S, Cui T, Wu X, Zhong Y, Yang X, Shen C, Gao Y
Journal of agricultural and food chemistry 2022 Nov 9;70(44):14220-14234
Journal of agricultural and food chemistry 2022 Nov 9;70(44):14220-14234
Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
Nakanishi A, Okumura H, Hashita T, Yamashita A, Nishimura Y, Watanabe C, Kamimura S, Hayashi S, Murakami S, Ito K, Iwao T, Ikeda A, Hirose T, Sunazuka T, Tanaka Y, Matsunaga T
Viruses 2022 Nov 8;14(11)
Viruses 2022 Nov 8;14(11)
Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy.
Chen Y, Zhang H, Li Y, Ji S, Jia P, Wang T
Journal of animal science and biotechnology 2022 Nov 4;13(1):125
Journal of animal science and biotechnology 2022 Nov 4;13(1):125
Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation.
Chen C, Zhang W, Zhou T, Liu Q, Han C, Huang Z, Chen S, Mei Q, Zhang C, Zhang K, Ma H, Zhou R, Jiang W, Pan W, Zhu S
Cell reports 2022 Nov 29;41(9):111741
Cell reports 2022 Nov 29;41(9):111741
Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells.
Chen L, Chen D, Li J, He L, Chen T, Song D, Shan S, Wang J, Lu X, Lu B
Cell death & disease 2022 Nov 28;13(11):1007
Cell death & disease 2022 Nov 28;13(11):1007
eIF4A3 Promotes RNA Viruses' Replication by Inhibiting Innate Immune Responses.
Gao Q, Jiang M, Zhao Y, Li G, Yang C, Ren C, Jin M, Chen H, Zhou H
Journal of virology 2022 Nov 23;96(22):e0151322
Journal of virology 2022 Nov 23;96(22):e0151322
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
Cao Y, Zhang M, Li Y, Lu J, Zhou W, Li X, Shi H, Xu B, Li S
International journal of molecular sciences 2022 Nov 22;23(23)
International journal of molecular sciences 2022 Nov 22;23(23)
BP5 alleviates endotoxemia-induced acute lung injury by activating Nrf2 via dual regulation of the Keap1-Nrf2 interaction and the Akt (Ser473)/GSK3β (Ser9)/Fyn pathway.
Li T, Geng Z, Zhang J, Xu L, Zhu X
Free radical biology & medicine 2022 Nov 20;193(Pt 1):304-318
Free radical biology & medicine 2022 Nov 20;193(Pt 1):304-318
Repeated Administration of Cisplatin Transforms Kidney Fibroblasts through G2/M Arrest and Cellular Senescence.
Yu JB, Lee DS, Padanilam BJ, Kim J
Cells 2022 Nov 2;11(21)
Cells 2022 Nov 2;11(21)
Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.
Yang R, Yang C, Ma L, Zhao Y, Guo Z, Niu J, Chu Q, Ma Y, Li B
Nature communications 2022 Nov 17;13(1):7031
Nature communications 2022 Nov 17;13(1):7031
A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator.
Guo J, Cheng M, Liu P, Cao D, Luo J, Wan Y, Fang Y, Jin Y, Xie SS, Liu J
European journal of medicinal chemistry 2022 Nov 15;242:114630
European journal of medicinal chemistry 2022 Nov 15;242:114630
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Zhang D, Li X, He X, Xing Y, Jiang B, Xiu Z, Bao Y, Dong Y
Molecules (Basel, Switzerland) 2022 Nov 12;27(22)
Molecules (Basel, Switzerland) 2022 Nov 12;27(22)
Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism.
Wang J, Zhang L, Cao H, Shi X, Zhang X, Gao Z, Ikeda K, Yan T, Jia Y, Xu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154022
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154022
Characterization of phalloidin-negative nuclear actin filaments in U2OS cells expressing cytoplasmic actin-EGFP.
Nagasaki A, Katoh K, Hoshi M, Doi M, Nakamura C, Uyeda TQP
Genes to cells : devoted to molecular & cellular mechanisms 2022 May;27(5):317-330
Genes to cells : devoted to molecular & cellular mechanisms 2022 May;27(5):317-330
Calpain-1 mediates vascular remodelling and fibrosis via HIF-1α in hypoxia-induced pulmonary hypertension.
Deng H, Tian X, Sun H, Liu H, Lu M, Wang H
Journal of cellular and molecular medicine 2022 May;26(10):2819-2830
Journal of cellular and molecular medicine 2022 May;26(10):2819-2830
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Tang K, Qin W, Wei R, Jiang Y, Fan L, Wang Z, Tan N
Pharmacological research 2022 May;179:106123
Pharmacological research 2022 May;179:106123
EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model.
Tao X, Zhang R, Du R, Yu T, Yang H, Li J, Wang Y, Liu Q, Zuo S, Wang X, Lazarus M, Zhou L, Wang B, Yu Y, Shen Y
The Journal of experimental medicine 2022 May 2;219(5)
The Journal of experimental medicine 2022 May 2;219(5)
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6
Molecular cell 2022 May 19;82(10):1821-1835.e6
An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.
Yang J, Li J, Guo H, Zhang Y, Guo Z, Liu Y, Huo T
International journal of molecular sciences 2022 May 19;23(10)
International journal of molecular sciences 2022 May 19;23(10)
Downregulated RRS1 inhibits invasion and metastasis of BT549 through RPL11‑c‑Myc‑SNAIL axis.
Wang R, Peng C, Song J, Hua Y, Wu Q, Deng L, Cao Y, Zhang J, Zhang L, Wu L, Hou L
International journal of oncology 2022 Mar;60(3)
International journal of oncology 2022 Mar;60(3)
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.
Zeng H, Qin H, Liao M, Zheng E, Luo X, Xiao A, Li Y, Chen L, Wei L, Zhao L, Ruan XZ, Yang P, Chen Y
Molecular metabolism 2022 Mar;57:101428
Molecular metabolism 2022 Mar;57:101428
High-frequency near-infrared diode laser irradiation suppresses IL-1β-induced inflammatory cytokine expression and NF-κB signaling pathways in human primary chondrocytes.
Sakata S, Kunimatsu R, Tsuka Y, Nakatani A, Gunji H, Yanoshita M, Kado I, Ito S, Putranti NAR, Prasetya RC, Hirose N, Tanimoto K
Lasers in medical science 2022 Mar;37(2):1193-1201
Lasers in medical science 2022 Mar;37(2):1193-1201
O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation.
Zhang H, Qi J, Pei J, Zhang M, Shang Y, Li Z, Wang Y, Guo J, Sun K, Fan J, Sui L, Xu Y, Kong L, Kong Y
Journal of advanced research 2022 Mar;37:119-131
Journal of advanced research 2022 Mar;37:119-131
Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia Through Activating AMPK/Nrf2 Pathway in Rats.
Li K, Jiang J, Shi Z, Zhan L, Peng L, Sun W, Tang Y, Zuo X, Xu E
Antioxidants & redox signaling 2022 Mar;36(7-9):567-591
Antioxidants & redox signaling 2022 Mar;36(7-9):567-591
Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro.
Mao J, Zhan H, Meng F, Wang G, Huang D, Liao Z, Chen M
Phytotherapy research : PTR 2022 Mar;36(3):1268-1283
Phytotherapy research : PTR 2022 Mar;36(3):1268-1283
Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
Tu Y, Tan L, Lu T, Wang K, Wang H, Han B, Zhao Y, Chen H, Li Y, Chen H, Chen M, He C
Biochemical pharmacology 2022 Mar;197:114912
Biochemical pharmacology 2022 Mar;197:114912
A novel mechanism of the lncRNA PTTG3P/miR-142-5p/JAG1 axis modulating tongue cancer cell phenotypes through the Notch1 signaling.
Zhang T, Liu X, Su K, Zheng Q, Liu P, Xu Z, Zhang Y
Cells & development 2022 Mar;169:203762
Cells & development 2022 Mar;169:203762
Bergamottin promotes osteoblast differentiation and bone formation via activating the Wnt/β-catenin signaling pathway.
Wang X, Tian Y, Liang X, Yin C, Huai Y, Zhao Y, Huang Q, Chu X, Wang W, Qian A
Food & function 2022 Mar 7;13(5):2913-2924
Food & function 2022 Mar 7;13(5):2913-2924
Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model.
Tian C, Zhang G, Xia Z, Chen N, Yang S, Li L
European journal of medicinal chemistry 2022 Mar 5;231:114122
European journal of medicinal chemistry 2022 Mar 5;231:114122
Usp8 promotes tumor cell migration through activating the JNK pathway.
Zhao Y, Peng D, Liu Y, Zhang Q, Liu B, Deng Y, Ding W, Zhou Z, Liu Q
Cell death & disease 2022 Mar 31;13(3):286
Cell death & disease 2022 Mar 31;13(3):286
The cancer/testis antigen HORMAD1 mediates epithelial-mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway in lung cancer.
Liu K, Cheng L, Zhu K, Wang J, Shu Q
Cell death discovery 2022 Mar 28;8(1):136
Cell death discovery 2022 Mar 28;8(1):136
Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling.
Liu P, Li Y, Li M, Zhou H, Zhang H, Zhang Y, Xu J, Xu Y, Zhang J, Xia B, Cheng H, Ke Y, Zhang X
iScience 2022 Mar 18;25(3):103867
iScience 2022 Mar 18;25(3):103867
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.
Zheng X, Xiao J, Jiang Q, Zheng L, Liu C, Dong C, Zheng Y, Ni P, Zhang C, Zhang F, Zhong R, Ding H, Wang Q, Qiu Y, Gao M, Ding J, Shen N, Wei B, Wang H
The EMBO journal 2022 Mar 15;41(6):e108016
The EMBO journal 2022 Mar 15;41(6):e108016
Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm.
Jin W, He Y, Li T, Long F, Qin X, Yuan Y, Gao G, Shakhawat HM, Liu X, Jin G, Zhou Z
Cell & bioscience 2022 Mar 15;12(1):31
Cell & bioscience 2022 Mar 15;12(1):31
Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.
Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248
Nature communications 2022 Mar 10;13(1):1248
Foxf2 represses bone formation via Wnt2b/β-catenin signaling.
Tanaka T, Takahashi A, Kobayashi Y, Saito M, Xiaolong S, Jingquan C, Ito Y, Kato T, Ochi H, Sato S, Yoshii T, Okawa A, Carlsson P, Inose H
Experimental & molecular medicine 2022 Jun;54(6):753-764
Experimental & molecular medicine 2022 Jun;54(6):753-764
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Chen Z, Tian L, Wang L, Ma X, Lei F, Chen X, Fu R
Inflammation 2022 Jun;45(3):992-1006
Inflammation 2022 Jun;45(3):992-1006
TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation.
Xu W, Liu C, Deng B, Lin P, Sun Z, Liu A, Xuan J, Li Y, Zhou K, Zhang X, Huang Q, Zhou H, He Q, Li B, Qu L, Yang J
Genome research 2022 Jun;32(6):1026-1041
Genome research 2022 Jun;32(6):1026-1041
Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation.
Ji R, Shi Q, Cao Y, Zhang J, Zhao C, Zhao H, Sayyed Y, Fu L, Li LY
The Journal of biological chemistry 2022 Jun;298(6):102033
The Journal of biological chemistry 2022 Jun;298(6):102033
TXNIP knockout improves cardiac function after myocardial infarction by promoting angiogenesis and reducing cardiomyocyte apoptosis.
Wang J, Wang XJ, Zhang Y, Shi WJ, Lei ZD, Jiao XY
Cardiovascular diagnosis and therapy 2022 Jun;12(3):289-304
Cardiovascular diagnosis and therapy 2022 Jun;12(3):289-304
Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5.
Qiu P, Jie Y, Ma C, Chen H, Qin Y, Tu K, Wang L, Zhang Z
Cell death discovery 2022 Jun 7;8(1):276
Cell death discovery 2022 Jun 7;8(1):276
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Yin BF, Li ZL, Yan ZQ, Guo Z, Liang JW, Wang Q, Zhao ZD, Li PL, Hao RC, Han MY, Li XT, Mao N, Ding L, Chen DF, Gao Y, Zhu H
Stem cell research & therapy 2022 Jun 7;13(1):241
Stem cell research & therapy 2022 Jun 7;13(1):241
Inflammation Induced by Lipopolysaccharide and Palmitic Acid Increases Cholesterol Accumulation via Enhancing Myeloid Differentiation Factor 88 Expression in HepG2 Cells.
Chen J, Liu Y, Luo H, Chen G, Zheng Z, Wang T, Hu X, Zhao Y, Tang J, Su C, Zha L
Pharmaceuticals (Basel, Switzerland) 2022 Jun 30;15(7)
Pharmaceuticals (Basel, Switzerland) 2022 Jun 30;15(7)
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
Lu J, Fu S, Dai J, Hu J, Li S, Ji H, Wang Z, Yu J, Bao J, Xu B, Guo J, Yang H
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis.
Huang Q, Wu D, Zhao J, Yan Z, Chen L, Guo S, Wang D, Yuan C, Wang Y, Liu X, Xing J
The EMBO journal 2022 Jun 1;41(11):e110324
The EMBO journal 2022 Jun 1;41(11):e110324
The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers.
Zhang Y, Ma Z, Li C, Wang C, Jiang W, Chang J, Han S, Lu Z, Shao Z, Wang Y, Wang H, Jiao C, Wang D, Wu X, Shen H, Wang X, Hu Z, Li X
Nature communications 2022 Jun 1;13(1):3061
Nature communications 2022 Jun 1;13(1):3061
PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer.
Ma H, Qi G, Han F, Peng J, Yuan C, Kong B
Experimental & molecular medicine 2022 Jul;54(7):999-1010
Experimental & molecular medicine 2022 Jul;54(7):999-1010
Gamma-oryzanol protects human liver cell (L02) from hydrogen peroxide-induced oxidative damage through regulation of the MAPK/Nrf2 signaling pathways.
Ma Y, Xiang S, Jiang W, Kong L, Tan Z, Liang Z, Yuan Z, Yi J, Zhu L
Journal of food biochemistry 2022 Jul;46(7):e14118
Journal of food biochemistry 2022 Jul;46(7):e14118
Exposure of mouse oocytes to N,N-dimethylformamide impairs mitochondrial functions and reduces oocyte quality.
Fei CF, Guo SM, Yin Y, He X, Zhou LQ
Environmental toxicology 2022 Jul;37(7):1563-1574
Environmental toxicology 2022 Jul;37(7):1563-1574
Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor-4 inhibition in hepatocellular carcinoma.
Iseda N, Itoh S, Toshida K, Tomiyama T, Morinaga A, Shimokawa M, Shimagaki T, Wang H, Kurihara T, Toshima T, Nagao Y, Harada N, Yoshizumi T, Mori M
Cancer science 2022 Jul;113(7):2272-2287
Cancer science 2022 Jul;113(7):2272-2287
Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells.
Yu C, Wang D, Li Q, Tong Y, Yang Z, Wang T
International immunopharmacology 2022 Jul;108:108872
International immunopharmacology 2022 Jul;108:108872
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Luo P, Huang Q, Chen S, Wang Y, Dou H
International immunopharmacology 2022 Jul;108:108864
International immunopharmacology 2022 Jul;108:108864
Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.
Zhang L, Yan J, Liu J, Meng C, Liu F, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154097
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154097
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
Oncogenic TRIB2 interacts with and regulates PKM2 to promote aerobic glycolysis and lung cancer cell procession.
Liu YR, Song DD, Liang DM, Li YJ, Yan YF, Sun HF, Zhang ML, Hu JX, Zhao YL, Liang Y, Li YM, Yang Z, Wang RR, Zheng HF, Wang P, Xie SY
Cell death discovery 2022 Jul 5;8(1):306
Cell death discovery 2022 Jul 5;8(1):306
Nucleome programming is required for the foundation of totipotency in mammalian germline development.
Nagano M, Hu B, Yokobayashi S, Yamamura A, Umemura F, Coradin M, Ohta H, Yabuta Y, Ishikura Y, Okamoto I, Ikeda H, Kawahira N, Nosaka Y, Shimizu S, Kojima Y, Mizuta K, Kasahara T, Imoto Y, Meehan K, Stocsits R, Wutz G, Hiraoka Y, Murakawa Y, Yamamoto T, Tachibana K, Peters JM, Mirny LA, Garcia BA, Majewski J, Saitou M
The EMBO journal 2022 Jul 4;41(13):e110600
The EMBO journal 2022 Jul 4;41(13):e110600
RFWD3 and translesion DNA polymerases contribute to PCNA modification-dependent DNA damage tolerance.
Kanao R, Kawai H, Taniguchi T, Takata M, Masutani C
Life science alliance 2022 Jul 29;5(12)
Life science alliance 2022 Jul 29;5(12)
Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis.
Miyake Y, Obana M, Yamamoto A, Noda S, Tanaka K, Sakai H, Tatsumoto N, Makino C, Kanemoto S, Shioi G, Tanaka S, Maeda M, Okada Y, Imaizumi K, Asanuma K, Fujio Y
Communications biology 2022 Jul 22;5(1):734
Communications biology 2022 Jul 22;5(1):734
Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity.
Hu G, Chen Y, Yang X, Wang Y, He J, Wang T, Fan Q, Deng L, Tu J, Tan H, Cheng J
Cell death & disease 2022 Jul 22;13(7):640
Cell death & disease 2022 Jul 22;13(7):640
Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis.
Liu J, Liu J, Meng C, Huang C, Liu F, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154173
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154173
Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription.
Zhao N, Wang F, Kong Z, Shang Y
Viruses 2022 Jul 2;14(7)
Viruses 2022 Jul 2;14(7)
DNA Repair Factor Poly(ADP-Ribose) Polymerase 1 Is a Proviral Factor in Hepatitis B Virus Covalently Closed Circular DNA Formation.
Chen Y, Yao Y, Zhao K, Liu C, Yuan Y, Sun H, Huang D, Zheng Y, Zhou Y, Chen J, Wang Y, Wu C, Zhang B, Guan Y, Li F, Pei R, Chen X
Journal of virology 2022 Jul 13;96(13):e0058522
Journal of virology 2022 Jul 13;96(13):e0058522
HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury.
Woods PS, Kimmig LM, Sun KA, Meliton AY, Shamaa OR, Tian Y, Cetin-Atalay R, Sharp WW, Hamanaka RB, Mutlu GM
eLife 2022 Jul 13;11
eLife 2022 Jul 13;11
Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis.
Yang X, Chen J, Wang J, Ma S, Feng W, Wu Z, Guo Y, Zhou H, Mi W, Chen W, Yin B, Lin Y
Immunity 2022 Jul 12;55(7):1185-1199.e8
Immunity 2022 Jul 12;55(7):1185-1199.e8
Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.
Lu Z, Huang L, Li Y, Xu Y, Zhang R, Zhou Q, Sun Q, Lu Y, Chen J, Shen Y, Li J, Zhao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(2):e2102669
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jan;9(2):e2102669
Increased m6A-RNA methylation and FTO suppression is associated with myocardial inflammation and dysfunction during endotoxemia in mice.
Dubey PK, Patil M, Singh S, Dubey S, Ahuja P, Verma SK, Krishnamurthy P
Molecular and cellular biochemistry 2022 Jan;477(1):129-141
Molecular and cellular biochemistry 2022 Jan;477(1):129-141
MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis.
Yue T, Sun F, Wang F, Yang C, Luo J, Rong S, Zhou H, Xiao J, Wang X, Zhou Q, Yang P, Zhang S, Li W, Xiong F, Yu Q, Wang CY
Cell death and differentiation 2022 Jan;29(1):218-229
Cell death and differentiation 2022 Jan;29(1):218-229
MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway.
Gu H, Li Y, Cui X, Cao H, Hou Z, Ti Y, Liu D, Gao J, Wang Y, Wen P
Biochemical pharmacology 2022 Jan;195:114870
Biochemical pharmacology 2022 Jan;195:114870
Dopamine inhibits the expression of proinflammatory cytokines of microglial cells through the formation of dopamine quinone in the mouse striatum.
Yoshioka Y, Sugino Y, Yamamuro A, Ishimaru Y, Maeda S
Journal of pharmacological sciences 2022 Jan;148(1):41-50
Journal of pharmacological sciences 2022 Jan;148(1):41-50
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Regulation of TET2 gene expression and 5mC oxidation in breast cancer cells by estrogen signaling.
Zhu X, Xiong L, Lyu R, Shen Y, Liu L, Li S, Argueta C, Tan L
Biochemical and biophysical research communications 2022 Jan 22;589:240-246
Biochemical and biophysical research communications 2022 Jan 22;589:240-246
Nuclear Fragility in Radiation-Induced Senescence: Blebs and Tubes Visualized by 3D Electron Microscopy.
Freyter BM, Abd Al-Razaq MA, Isermann A, Dietz A, Azimzadeh O, Hekking L, Gomolka M, Rübe CE
Cells 2022 Jan 13;11(2)
Cells 2022 Jan 13;11(2)
Bombyx mori Akirin hijacks a viral peptide vSP27 encoded by BmCPV circRNA and activates the ROS-NF-κB pathway against viral infection.
Zhang Y, Zhang X, Dai K, Zhu M, Liang Z, Pan J, Zhang Z, Xue R, Cao G, Hu X, Gong C
International journal of biological macromolecules 2022 Jan 1;194:223-232
International journal of biological macromolecules 2022 Jan 1;194:223-232
PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation.
Chen Q, Lu H, Duan C, Zhu X, Zhang Y, Li M, Zhang D
Inflammation 2022 Feb;45(1):234-252
Inflammation 2022 Feb;45(1):234-252
C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
Gao Z, Zhang C, Feng Z, Liu Z, Yang Y, Yang K, Chen L, Yao R
Experimental neurology 2022 Feb;348:113947
Experimental neurology 2022 Feb;348:113947
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy.
Wang N, Huang R, Yang K, He Y, Gao Y, Dong D
Journal of cellular and molecular medicine 2022 Feb;26(3):893-912
Journal of cellular and molecular medicine 2022 Feb;26(3):893-912
Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.
Bai Z, Zhou Y, Ye X, Li Y, Peng Y, Guan Q, Zhang W, Ma L
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119174
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119174
Matrix remodeling controls a nuclear lamin A/C-emerin network that directs Wnt-regulated stem cell fate.
Tang Y, Zhu L, Cho JS, Li XY, Weiss SJ
Developmental cell 2022 Feb 28;57(4):480-495.e6
Developmental cell 2022 Feb 28;57(4):480-495.e6
A Redox-Silent Analogue of Tocotrienol May Break the Homeostasis of Proteasomes in Human Malignant Mesothelioma Cells by Inhibiting STAT3 and NRF1.
Ishii K, Fusegi M, Mori T, Teshima K, Ninomiya N, Kohno K, Sato A, Ishida T, Miyakoshi Y, Yano T
International journal of molecular sciences 2022 Feb 28;23(5)
International journal of molecular sciences 2022 Feb 28;23(5)
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Liu H, Zhao D, Li H, Zhang W, Lin Q, Wang X, Zheng S, Zhang L, Li L, Hu S, Hu Y
Cell death & disease 2022 Feb 21;13(2):166
Cell death & disease 2022 Feb 21;13(2):166
Novel stress granule-like structures are induced via a paracrine mechanism during viral infection.
Iadevaia V, Burke JM, Eke L, Moller-Levet C, Parker R, Locker N
Journal of cell science 2022 Feb 15;135(4)
Journal of cell science 2022 Feb 15;135(4)
Blockade of Nuclear β-Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis.
Zheng CC, Liao L, Liu YP, Yang YM, He Y, Zhang GG, Li SJ, Liu T, Xu WW, Li B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Dec;9(34):e2202528
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Dec;9(34):e2202528
TERC suppresses PD-L1 expression by downregulating RNA binding protein HuR.
Jin H, Chen Y, Ren J, Huang J, Zhao Y, Liu H
Science China. Life sciences 2022 Dec;65(12):2505-2516
Science China. Life sciences 2022 Dec;65(12):2505-2516
A polypeptide inhibitor of calcineurin blocks the calcineurin-NFAT signalling pathway in vivo and in vitro.
Wang P, Li W, Yang Y, Cheng N, Zhang Y, Zhang N, Yin Y, Tong L, Li Z, Luo J
Journal of enzyme inhibition and medicinal chemistry 2022 Dec;37(1):202-210
Journal of enzyme inhibition and medicinal chemistry 2022 Dec;37(1):202-210
KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy.
Tan Z, Ren H, Liu Y, Yang H, Luo Q, Deng X
Experimental and therapeutic medicine 2022 Dec;24(6):737
Experimental and therapeutic medicine 2022 Dec;24(6):737
LINC02535/miR-30a-5p/GALNT3 axis contributes to lung adenocarcinoma progression via the NF- κ B signaling pathway.
Li Y, Zhao J, Zhang W, Wang A, Jiao M, Cai X, Zhu J, Liu Z, Huang JA
Cell cycle (Georgetown, Tex.) 2022 Dec;21(23):2455-2470
Cell cycle (Georgetown, Tex.) 2022 Dec;21(23):2455-2470
Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer.
Fan M, Gao J, Zhou L, Xue W, Wang Y, Chen J, Li W, Yu Y, Liu B, Shen Y, Xu Q
Acta pharmaceutica Sinica. B 2022 Dec;12(12):4407-4423
Acta pharmaceutica Sinica. B 2022 Dec;12(12):4407-4423
Procyanidin B2 ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Cai W, Zhang Y, Jin W, Wei S, Chen J, Zhong C, Zhong Y, Tu C, Peng H
International immunopharmacology 2022 Dec;113(Pt A):109336
International immunopharmacology 2022 Dec;113(Pt A):109336
The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription.
Li P, Wu J, Liu S, Lu R, Jiang H, Wang N, Luo M, Guo L, Xiao J, Bu L, Liu L, Xing F, Peng H, Li C, Ma L, Zhao B, Zhou Z, Guo D
Proceedings of the National Academy of Sciences of the United States of America 2022 Dec 6;119(49):e2205013119
Proceedings of the National Academy of Sciences of the United States of America 2022 Dec 6;119(49):e2205013119
Nrf2 Deficiency Exacerbated CLP-Induced Pulmonary Injury and Inflammation through Autophagy- and NF-κB/PPARγ-Mediated Macrophage Polarization.
Luo J, Wang J, Zhang J, Sang A, Ye X, Cheng Z, Li X
Cells 2022 Dec 4;11(23)
Cells 2022 Dec 4;11(23)
C/D box small nucleolar RNA SNORD104 promotes endometrial cancer by regulating the 2'-O-methylation of PARP1.
Lu B, Chen X, Liu X, Chen J, Qin H, Chen S, Zhao Y
Journal of translational medicine 2022 Dec 24;20(1):618
Journal of translational medicine 2022 Dec 24;20(1):618
PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB.
Li H, Liu Z, Wang Y, Wang H, Cai J, Tang C, Dong Z
Clinical science (London, England : 1979) 2022 Dec 22;136(24):1877-1891
Clinical science (London, England : 1979) 2022 Dec 22;136(24):1877-1891
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.
Shi K, Xiao Y, Dong Y, Wang D, Xie Y, Tu J, Xu K, Zhou Z, Cao G, Liu Y
International journal of molecular sciences 2022 Dec 17;23(24)
International journal of molecular sciences 2022 Dec 17;23(24)
Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.
Ma G, Zhao Z, Qu Y, Cai F, Liu S, Liang H, Zhang R, Deng J
Cell death discovery 2022 Dec 16;8(1):493
Cell death discovery 2022 Dec 16;8(1):493
Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5.
Chen X, He X, Yang YY, Wang Y
ACS chemical biology 2022 Dec 16;17(12):3450-3457
ACS chemical biology 2022 Dec 16;17(12):3450-3457
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
Identification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in males.
Zhou X, Zhang X, Zhou X, Abulimiti G, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Yang J, Song N
Ecotoxicology and environmental safety 2022 Dec 1;247:114241
Ecotoxicology and environmental safety 2022 Dec 1;247:114241
Electrostatic anti-CD33-antibody-protamine nanocarriers as platform for a targeted treatment of acute myeloid leukemia.
Bäumer N, Scheller A, Wittmann L, Faust A, Apel M, Nimmagadda SC, Geyer C, Grunert K, Kellmann N, Peipp M, Kailayangiri S, Gutierrez Suburu ME, Strassert CA, Schenk M, Greune L, Rüter C, Dersch P, Hartmann W, Rossig C, Neri D, Müller-Tidow C, Schwöppe C, Schliemann C, Khandanpour C, Lenz G, Berdel WE, Bäumer S
Journal of hematology & oncology 2022 Dec 1;15(1):171
Journal of hematology & oncology 2022 Dec 1;15(1):171
N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth.
Liu Y, Lan L, Li Y, Lu J, He L, Deng Y, Fei M, Lu JW, Shangguan F, Lu JP, Wang J, Wu L, Huang K, Lu B
Redox biology 2022 Aug;54:102366
Redox biology 2022 Aug;54:102366
The Integrated Analysis of Transcriptomics and Metabolomics Unveils the Therapeutical Effect of Asiatic Acid on Alcoholic Hepatitis in Rats.
Chen S, Huang Y, Su H, Zhu W, Wei Y, Long Y, Shi Y, Wei J
Inflammation 2022 Aug;45(4):1780-1799
Inflammation 2022 Aug;45(4):1780-1799
TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.
Liu C, Li Y, Wang X
Inflammation 2022 Aug;45(4):1520-1533
Inflammation 2022 Aug;45(4):1520-1533
Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway.
Liu WW, Wang F, Li C, Song XY, Otkur W, Zhu YY, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Acta pharmacologica Sinica 2022 Aug;43(8):2156-2167
Acta pharmacologica Sinica 2022 Aug;43(8):2156-2167
PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease.
Wang XJ, Qi L, Cheng YF, Ji XF, Chi TY, Liu P, Zou LB
Acta pharmacologica Sinica 2022 Aug;43(8):1916-1927
Acta pharmacologica Sinica 2022 Aug;43(8):1916-1927
Polysaccharide extract from Isatidis Radix inhibits multiple inflammasomes activation and alleviate gouty arthritis.
Ren L, Li Q, Li H, Zhan X, Yang R, Li Z, Fang Z, Liu T, Wei Z, Zhao J, Lin L, Mou W, Dai W, Bai Z, Xu G, Cao J
Phytotherapy research : PTR 2022 Aug;36(8):3295-3312
Phytotherapy research : PTR 2022 Aug;36(8):3295-3312
Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.
Li X, Zhang Y, Zhao Y, Zhou Y, Han Q, Yang Y, Zhang L, Shi L, Jin X, Zhang R, Gao H, Xue G, Li D, Zhang ZR, Lu Y, Yang B, Pan Z
Pharmacological research 2022 Aug;182:106284
Pharmacological research 2022 Aug;182:106284
Protective activity of tert-butylhydroquinone against oxidative stress and apoptosis induced by glutamate agonizts in R28 cells and mice retina.
Dai S, Wang C, Feng L, Zhang C, Zhang W, He Y, Zhou X, Xia X, Chen B, Song W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113117
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113117
Trans-anethole ameliorates lipopolysaccharide-induced acute liver inflammation in broilers via inhibiting NF-κB signaling pathway.
Tong Y, Yu C, Xie Z, Zhang X, Yang Z, Wang T
Poultry science 2022 Aug;101(8):101962
Poultry science 2022 Aug;101(8):101962
The Antimicrobial Peptides Human β-Defensins Induce the Secretion of Angiogenin in Human Dermal Fibroblasts.
Umehara Y, Takahashi M, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F
International journal of molecular sciences 2022 Aug 8;23(15)
International journal of molecular sciences 2022 Aug 8;23(15)
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH).
Li X, Ding K, Li X, Yuan B, Wang Y, Yao Z, Wang S, Huang H, Xu B, Xie L, Deng T, Chen XW, Chen Z
Nature communications 2022 Aug 4;13(1):4549
Nature communications 2022 Aug 4;13(1):4549
A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
Griffin WC, McKinzey DR, Klinzing KN, Baratam R, Eliyapura A, Trakselis MA
Nature communications 2022 Aug 30;13(1):5090
Nature communications 2022 Aug 30;13(1):5090
Methyltransferase Setdb1 Promotes Osteoblast Proliferation by Epigenetically Silencing Macrod2 with the Assistance of Atf7ip.
Zhang L, Xu L, Zhang X, Wang K, Tan Y, Li G, Wang Y, Xue T, Sun Q, Cao X, Zhang G, Hu Z, Zhang S, Shi F
Cells 2022 Aug 19;11(16)
Cells 2022 Aug 19;11(16)
Glycosylated modification of MUC1 maybe a new target to promote drug sensitivity and efficacy for breast cancer chemotherapy.
Xi X, Wang J, Qin Y, Huang W, You Y, Zhan J
Cell death & disease 2022 Aug 16;13(8):708
Cell death & disease 2022 Aug 16;13(8):708
Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling.
Zhu P, Jin Z, Kang G, Jia Y, Liu D, Zhang Q, Guo F, Jia Y, Jiao Y, Li J, Sun H, Ma X
Cell communication and signaling : CCS 2022 Aug 15;20(1):121
Cell communication and signaling : CCS 2022 Aug 15;20(1):121
Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.
Shi Y, Chen J, Li S, Wu Y, Yu C, Ni L, Xiao J, Shao Z, Zhu H, Wang J, Wang X, Zhang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153928
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153928
PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway.
Lee DH, Park JS, Lee YS, Bae SH
Redox biology 2022 Apr;50:102235
Redox biology 2022 Apr;50:102235
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.
Wang K, Zhang B, Zhang B, Wu K, Tian T, Yan W, Huang M
Neurotoxicity research 2022 Apr;40(2):520-529
Neurotoxicity research 2022 Apr;40(2):520-529
C1q/tumor necrosis factor-related protein 9 protects cultured chondrocytes from IL-1β-induced inflammatory injury by inhibiting NLRP3 inflammasome activation via the AdipoR1/AMPK axis.
Wang B, Li Y, Hu S, Peng K
Environmental toxicology 2022 Apr;37(4):889-898
Environmental toxicology 2022 Apr;37(4):889-898
MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13.
Jin X, Yu W, Ye P
Environmental toxicology 2022 Apr;37(4):730-740
Environmental toxicology 2022 Apr;37(4):730-740
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Wu XY, Wang T, Hu HX, Zhang K, Zhao Y, Zhao BB, Lou HX, Wang XN, Shen T
Phytotherapy research : PTR 2022 Apr;36(4):1692-1707
Phytotherapy research : PTR 2022 Apr;36(4):1692-1707
Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κ B and PI3K/AKT Signaling In Vitro and In Vivo.
Xuan L, Hu JH, Bi R, Liu SQ, Wang CX
Chinese journal of integrative medicine 2022 Apr;28(4):349-356
Chinese journal of integrative medicine 2022 Apr;28(4):349-356
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
Dubey S, Dubey PK, Umeshappa CS, Ghebre YT, Krishnamurthy P
Journal of cellular physiology 2022 Apr;237(4):2169-2182
Journal of cellular physiology 2022 Apr;237(4):2169-2182
N-acetylcysteine promotes cyclic mechanical stress-induced osteogenic differentiation of periodontal ligament stem cells by down-regulating Nrf2 expression.
Xi X, Li ZX, Zhao Y, Liu H, Chen S, Liu DX
Journal of dental sciences 2022 Apr;17(2):750-762
Journal of dental sciences 2022 Apr;17(2):750-762
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
LATS1 is a central signal transmitter for achieving full type-I interferon activity.
Zuo Y, He J, Liu S, Xu Y, Liu J, Qiao C, Zang L, Sun W, Yuan Y, Zhang H, Chen X, Jin L, Miao Y, Huang F, Ren T, Wang J, Qian F, Zhu C, Zhang W, Liu Y, Xu G, Ma F, Zheng H
Science advances 2022 Apr 8;8(14):eabj3887
Science advances 2022 Apr 8;8(14):eabj3887
Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.
Li L, Zhong S, Li R, Liang N, Zhang L, Xia S, Xu X, Chen X, Chen S, Tao Y, Yin H
JCI insight 2022 Apr 8;7(7)
JCI insight 2022 Apr 8;7(7)
Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes.
Du X, Osoro EK, Chen Q, Yan X, Gao D, Wu L, Ren J, Feng L, Wu N, Lu K, Yang X, Zhong B, Han Y, Zhang F, Li D, Lan X, Lu S
Molecular and cellular endocrinology 2022 Apr 5;545:111562
Molecular and cellular endocrinology 2022 Apr 5;545:111562
Relationship between Neuroprotective Effects and Structure of Procyanidins.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Apr 2;27(7)
Molecules (Basel, Switzerland) 2022 Apr 2;27(7)
Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex.
Ohno SI, Oikawa K, Tsurui T, Harada Y, Ono K, Tateishi M, Mirza A, Takanashi M, Kanekura K, Nagase K, Shimada Y, Kudo Y, Ikeda N, Ochiya T, Wang X, Kuroda M
Cell reports 2022 Apr 12;39(2):110673
Cell reports 2022 Apr 12;39(2):110673
CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling.
Chen D, Zhou H, Cai Z, Cai K, Liu J, Wang W, Miao H, Li H, Li R, Li X, Chen Y, Wang HY, Wen Z
Journal of experimental & clinical cancer research : CR 2022 Apr 1;41(1):120
Journal of experimental & clinical cancer research : CR 2022 Apr 1;41(1):120
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Jin C, Ou Q, Chen J, Wang T, Zhang J, Wang Z, Wang Y, Tian H, Xu JY, Gao F, Wang J, Li J, Lu L, Xu GT
Stem cell research & therapy 2022 Apr 1;13(1):136
Stem cell research & therapy 2022 Apr 1;13(1):136
Golgi Phosphoprotein 3 Confers Radioresistance via Stabilizing EGFR in Lung Adenocarcinoma.
Chen G, Kong P, Yang M, Hu W, Prise KM, Yu KN, Cui S, Qin F, Meng G, Almahi WA, Nie L, Han W
International journal of radiation oncology, biology, physics 2022 Apr 1;112(5):1216-1228
International journal of radiation oncology, biology, physics 2022 Apr 1;112(5):1216-1228
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Xi X, Li Z, Liu H, Chen S, Liu D
Frontiers in cell and developmental biology 2021;9:816000
Frontiers in cell and developmental biology 2021;9:816000
TLR5 Supports Development of Placental Labyrinthine Zone in Mice.
Yiu JHC, Cheung SWM, Cai J, Chan KS, Chen J, Cheong LY, Chau HT, Xu A, Li RHW, Woo CW
Frontiers in cell and developmental biology 2021;9:711253
Frontiers in cell and developmental biology 2021;9:711253
Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing Enterocolitis.
Yu S, Lv Z, Gao Z, Shi J, Sheng Q, Zheng L, Zhou J, Wang X
Frontiers in pediatrics 2021;9:710382
Frontiers in pediatrics 2021;9:710382
TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer.
Yang B, Chen J, Teng Y
Journal of immunology research 2021;2021:9994004
Journal of immunology research 2021;2021:9994004
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Li X, Wang X, Miao L, Guo Y, Yuan R, Ren J, Huang Y, Tian H
Oxidative medicine and cellular longevity 2021;2021:4714649
Oxidative medicine and cellular longevity 2021;2021:4714649
YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis.
Zhang T, Beeharry MK, Wang Z, Zhu Z, Li J, Li C
International journal of biological sciences 2021;17(7):1629-1643
International journal of biological sciences 2021;17(7):1629-1643
SNX25 regulates proinflammatory cytokine expression via the NF-κB signal in macrophages.
Nishimura K, Tanaka T, Takemura S, Tatsumi K, Wanaka A
PloS one 2021;16(3):e0247840
PloS one 2021;16(3):e0247840
HIV-1 Vpr protein upregulates microRNA-210-5p expression to induce G2 arrest by targeting TGIF2.
Qiao J, Peng Q, Qian F, You Q, Feng L, Hu S, Liu W, Huang L, Shu X, Sun B
PloS one 2021;16(12):e0261971
PloS one 2021;16(12):e0261971
Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling.
Fu Y, Jia J
Frontiers in neuroscience 2021;15:638772
Frontiers in neuroscience 2021;15:638772
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Wang H, Jiang Z, Pang Z, Qi G, Hua B, Yan Z, Yuan H
Journal of inflammation research 2021;14:745-760
Journal of inflammation research 2021;14:745-760
RNF128 suppresses the malignancy of colorectal cancer cells via inhibition of Wnt/β-catenin signaling.
Zhu Y, Gan Y, Zou R, Sha H, Lu Y, Zhang Y, Feng J
American journal of translational research 2021;13(12):13567-13578
American journal of translational research 2021;13(12):13567-13578
Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/β-catenin Pathway.
Xie X, Zhou Z, Song Y, Zhang X, Dang C, Zhang H
Journal of Cancer 2021;12(15):4574-4584
Journal of Cancer 2021;12(15):4574-4584
Activation of α7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson's Disease Rats.
Zhou L, Zheng LF, Zhang XL, Wang ZY, Yao YS, Xiu XL, Liu CZ, Zhang Y, Feng XY, Zhu JX
Frontiers in pharmacology 2021;12:793374
Frontiers in pharmacology 2021;12:793374
Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival.
Jiang J, Dong C, Zhai L, Lou J, Jin J, Cheng S, Chen Z, Guo X, Lin D, Ding J, Gao W
Frontiers in pharmacology 2021;12:735530
Frontiers in pharmacology 2021;12:735530
AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Kong L, Zhang H, Lu C, Shi K, Huang H, Zheng Y, Wang Y, Wang D, Wang H, Huang W
Frontiers in pharmacology 2021;12:724514
Frontiers in pharmacology 2021;12:724514
Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway.
Wang J, Jiang W, Xin J, Xue W, Shi C, Wen J, Huang Y, Hu C
Frontiers in pharmacology 2021;12:717276
Frontiers in pharmacology 2021;12:717276
Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway.
Chen P, Wen Z, Shi W, Li Z, Chen X, Gao Y, Xu S, Gong Q, Deng J
Frontiers in pharmacology 2021;12:674570
Frontiers in pharmacology 2021;12:674570
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
Li R, Yang W, Yin Y, Ma X, Zhang P, Tao K
Frontiers in pharmacology 2021;12:651444
Frontiers in pharmacology 2021;12:651444
Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation.
Cao L, Xu C, Yi P, Li H, Lin Y, Cai G, Wang S, Ou D, Li M, Chen J
American journal of cancer research 2021;11(4):1206-1225
American journal of cancer research 2021;11(4):1206-1225
Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells.
Gao Y, Chen MK, Chu YY, Yang L, Yu D, Liu Y, Hung MC
American journal of cancer research 2021;11(1):236-250
American journal of cancer research 2021;11(1):236-250
PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression.
Sun Q, Yuan M, Wang H, Zhang X, Zhang R, Wang H, Chen X, Zhu M, Liu S, Wu J
Frontiers in oncology 2021;11:767116
Frontiers in oncology 2021;11:767116
TGF-β1 Induces Immune Escape by Enhancing PD-1 and CTLA-4 Expression on T Lymphocytes in Hepatocellular Carcinoma.
Bao S, Jiang X, Jin S, Tu P, Lu J
Frontiers in oncology 2021;11:694145
Frontiers in oncology 2021;11:694145
Yangonin modulates lipid homeostasis, ameliorates cholestasis and cellular senescence in alcoholic liver disease via activating nuclear receptor FXR.
Kong L, Dong R, Huang K, Wang X, Wang D, Yue N, Wang C, Sun P, Gu J, Luo H, Liu K, Wu J, Sun H, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Sep;90:153629
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Sep;90:153629
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells.
Wu J, Wu C, Xing F, Cao L, Zeng W, Guo L, Li P, Zhong Y, Jiang H, Luo M, Shi G, Bu L, Ji Y, Hou P, Peng H, Huang J, Li C, Guo D
Cell research 2021 Sep;31(9):998-1010
Cell research 2021 Sep;31(9):998-1010
Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Zhang L, Jiang X, Liu N, Li M, Kang J, Chen L, Tang J, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
Zeng S, Chen L, Sun Q, Zhao H, Yang H, Ren S, Liu M, Meng X, Xu H
European journal of pharmacology 2021 Sep 5;906:174253
European journal of pharmacology 2021 Sep 5;906:174253
HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading.
Xu L, Zhang L, Zhang X, Li G, Wang Y, Dong J, Wang H, Hu Z, Cao X, Zhang S, Shi F
International journal of molecular sciences 2021 Sep 29;22(19)
International journal of molecular sciences 2021 Sep 29;22(19)
18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.
Chen B, Zhu D, Xie C, Shi Y, Ni L, Zhang H, Li S, Lu J, Xiao J, Xia W, Huang C, Wang X
Food & function 2021 Sep 20;12(18):8399-8410
Food & function 2021 Sep 20;12(18):8399-8410
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
MicroRNA-30c-5p protects against myocardial ischemia/reperfusion injury via regulation of Bach1/Nrf2.
Sun M, Guo M, Ma G, Zhang N, Pan F, Fan X, Wang R
Toxicology and applied pharmacology 2021 Sep 1;426:115637
Toxicology and applied pharmacology 2021 Sep 1;426:115637
TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling.
Hu S, Li Y, Wang B, Peng K
International immunopharmacology 2021 Oct;99:108048
International immunopharmacology 2021 Oct;99:108048
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Wen L, Yang QH, Ma XL, Li T, Xiao S, Sun CF
International immunopharmacology 2021 Oct;99:107993
International immunopharmacology 2021 Oct;99:107993
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Fan S, Liu X, Wang Y, Ren X, Liu Y, Dong Y, Fan Q, Wei J, Ma J, Yu A, Song R, Sui H, Shen M, Fang F, Xia Q, She G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
Yu S, Lu Y, Su A, Chen J, Li J, Zhou B, Liu X, Xia Q, Li Y, Li J, Huang M, Ye Y, Zhao Q, Jiang S, Yan X, Wang X, Di C, Pan J, Su S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Oct;8(19):e2101848
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Oct;8(19):e2101848
Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide.
Suzuki T, Yamashita S, Hattori K, Matsuda N, Hattori Y
Naunyn-Schmiedeberg's archives of pharmacology 2021 Oct;394(10):2129-2139
Naunyn-Schmiedeberg's archives of pharmacology 2021 Oct;394(10):2129-2139
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo.
Wang B, Wang L, Gasek NS, Zhou Y, Kim T, Guo C, Jellison ER, Haynes L, Yadav S, Tchkonia T, Kuchel GA, Kirkland JL, Xu M
Nature aging 2021 Oct;1(10):962-973
Nature aging 2021 Oct;1(10):962-973
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Han Y, Xiong S, Zhao H, Yang S, Yang M, Zhu X, Jiang N, Xiong X, Gao P, Wei L, Xiao Y, Sun L
Cell death & disease 2021 Oct 30;12(11):1031
Cell death & disease 2021 Oct 30;12(11):1031
Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway in rat hippocampus.
Wang J, Chen R, Liu C, Wu X, Zhang Y
European journal of pharmacology 2021 Oct 15;909:174396
European journal of pharmacology 2021 Oct 15;909:174396
Cynandione A causes a dynamic change in SIRT1 nuclear trafficking via PKA signaling and beige adipocyte differentiation in 3T3-L1 cells.
Sawamoto A, Kanazaki A, Nakanishi M, Amakura Y, Yoshimura M, Uchiyama N, Hakamatsuka T, Okuyama S, Nakajima M
European journal of pharmacology 2021 Oct 15;909:174382
European journal of pharmacology 2021 Oct 15;909:174382
Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level.
Liu Z, Xia X, Lv X, Song E, Song Y
Environmental pollution (Barking, Essex : 1987) 2021 Oct 15;287:117345
Environmental pollution (Barking, Essex : 1987) 2021 Oct 15;287:117345
Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.
Okubo Y, Ohtake F, Igarashi K, Yasuhiko Y, Hirabayashi Y, Saga Y, Kanno J
Development (Cambridge, England) 2021 Oct 1;148(19)
Development (Cambridge, England) 2021 Oct 1;148(19)
Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-κB signaling pathway.
Yuan L, Zhang L, Yao N, Wu L, Liu J, Liu F, Zhang H, Hu X, Xiong Y, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153726
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153726
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Xu J, Zhang L, Jiang R, Hu K, Hu D, Liao C, Jiang S, Yang Y, Huang J, Tang L, Li L
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Loss of PHLDA1 has a protective role in OGD/R-injured neurons via regulation of the GSK-3β/Nrf2 pathway.
Yang F, Chen R
Human & experimental toxicology 2021 Nov;40(11):1909-1920
Human & experimental toxicology 2021 Nov;40(11):1909-1920
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
Cui Q, Yan L
Cell and tissue research 2021 Nov;386(2):349-363
Cell and tissue research 2021 Nov;386(2):349-363
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
Meng X, Zhang L, Han B, Zhang Z
Environmental toxicology 2021 Nov;36(11):2266-2277
Environmental toxicology 2021 Nov;36(11):2266-2277
AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
Fang P, Deng WJ, Fan N, Shi J, Shi HY, Ou L, Pan JL, Yang SY
Environmental toxicology 2021 Nov;36(11):2225-2235
Environmental toxicology 2021 Nov;36(11):2225-2235
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
Park J, Lee J, Kim JH, Lee J, Park H, Lim C
Nucleic acids research 2021 Nov 8;49(19):11294-11311
Nucleic acids research 2021 Nov 8;49(19):11294-11311
G-Quadruplexes Formation at the Upstream Region of Replication Origin (OriL) of the Pseudorabies Virus: Implications for Antiviral Targets.
Zhu Y, Liu W, Zhang C
Viruses 2021 Nov 4;13(11)
Viruses 2021 Nov 4;13(11)
Cilia locally synthesize proteins to sustain their ultrastructure and functions.
Hao K, Chen Y, Yan X, Zhu X
Nature communications 2021 Nov 30;12(1):6971
Nature communications 2021 Nov 30;12(1):6971
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability.
Wu B, Yang C, Fang Y, Ding W, Zhang Y
Environmental toxicology 2021 May;36(5):840-849
Environmental toxicology 2021 May;36(5):840-849
MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling.
Li D, Chen S, Zhang W, Zhang C, Sun T, Du Y, Ding R, Gao Y, Jin Y, Duan G
Cellular & molecular immunology 2021 May;18(5):1320-1322
Cellular & molecular immunology 2021 May;18(5):1320-1322
RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.
Kim JI, Nakahama T, Yamasaki R, Costa Cruz PH, Vongpipatana T, Inoue M, Kanou N, Xing Y, Todo H, Shibuya T, Kato Y, Kawahara Y
PLoS genetics 2021 May;17(5):e1009516
PLoS genetics 2021 May;17(5):e1009516
Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo.
Zhang C, Li Q, Qin G, Zhang Y, Li C, Han L, Wang R, Wang S, Chen H, Liu K, He C
Chinese medicine 2021 May 31;16(1):41
Chinese medicine 2021 May 31;16(1):41
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Zhang J, Ma X, Fan D
Foods (Basel, Switzerland) 2021 May 26;10(6)
Foods (Basel, Switzerland) 2021 May 26;10(6)
Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus.
Wang Q, Xin Q, Shang W, Wan W, Xiao G, Zhang LK
Viruses 2021 May 25;13(6)
Viruses 2021 May 25;13(6)
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Molecules (Basel, Switzerland) 2021 May 17;26(10)
G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses.
Cai H, Liu X, Zhang F, Han QY, Liu ZS, Xue W, Guo ZL, Zhao JM, Sun LM, Wang N, Mao J, He K, Xia T, Chen Y, Chen L, Li AL, Zhou T, Zhang XM, Li WH, Li T
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2453-2467
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2453-2467
Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer.
Shi W, Zhang G, Ma Z, Li L, Liu M, Qin L, Yu Z, Zhao L, Liu Y, Zhang X, Qin J, Ye H, Jiang X, Zhou H, Sun H, Jiao Z
Nature communications 2021 May 14;12(1):2812
Nature communications 2021 May 14;12(1):2812
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Kishi S, Nishiguchi Y, Honoki K, Mori S, Fujiwara-Tani R, Sasaki T, Fujii K, Kawahara I, Goto K, Nakashima C, Kido A, Tanaka Y, Luo Y, Kuniyasu H
International journal of molecular sciences 2021 May 13;22(10)
International journal of molecular sciences 2021 May 13;22(10)
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
Qin W, Tong X, Liang R, Tang K, Wu X, Jia Y, Tan N
Journal of ethnopharmacology 2021 May 10;271:113827
Journal of ethnopharmacology 2021 May 10;271:113827
6-Gingerol attenuates ventilator-induced lung injury via anti-inflammation and antioxidative stress by modulating the PPARγ/NF-κBsignalling pathway in rats.
Hong W, Zhi FX, Kun TH, Hua FJ, Huan Ling L, Fang F, Wen C, Jie W, Yang LC
International immunopharmacology 2021 Mar;92:107367
International immunopharmacology 2021 Mar;92:107367
Chromothripsis drives the evolution of gene amplification in cancer.
Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW
Nature 2021 Mar;591(7848):137-141
Nature 2021 Mar;591(7848):137-141
Protein kinase D participates in cardiomyocyte hypertrophy by regulating extracellular signal-regulated and myocyte enhancer factor 2D.
Yuan H, Xiang Q, Yang L, Geng J
Revista portuguesa de cardiologia 2021 Mar;40(3):191-200
Revista portuguesa de cardiologia 2021 Mar;40(3):191-200
Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Shao Z, Wang B, Shi Y, Xie C, Huang C, Chen B, Zhang H, Zeng G, Liang H, Wu Y, Zhou Y, Tian N, Wu A, Gao W, Wang X, Zhang X
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
Osteoarthritis and cartilage 2021 Mar;29(3):413-422
Silibinin treatment protects human skin cells from UVB injury through upregulation of estrogen receptors.
Liu W, Wang F, Li C, Otkur W, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Onodera S, Ikejima T
Journal of photochemistry and photobiology. B, Biology 2021 Mar;216:112147
Journal of photochemistry and photobiology. B, Biology 2021 Mar;216:112147
ATF3 drives senescence by reconstructing accessible chromatin profiles.
Zhang C, Zhang X, Huang L, Guan Y, Huang X, Tian XL, Zhang L, Tao W
Aging cell 2021 Mar;20(3):e13315
Aging cell 2021 Mar;20(3):e13315
5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expression in TET2-Deficient Erythroleukemia Cells.
Reilly BM, Luger T, Park S, Lio CJ, González-Avalos E, Wheeler EC, Lee M, Williamson L, Tanaka T, Diep D, Zhang K, Huang Y, Rao A, Bejar R
Molecular cancer research : MCR 2021 Mar;19(3):451-464
Molecular cancer research : MCR 2021 Mar;19(3):451-464
Disease Modeling with Human Neurons Reveals LMNB1 Dysregulation Underlying DYT1 Dystonia.
Ding B, Tang Y, Ma S, Akter M, Liu ML, Zang T, Zhang CL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Mar 3;41(9):2024-2038
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Mar 3;41(9):2024-2038
Salubrinal Alleviates Collagen-Induced Arthritis through Promoting P65 Degradation in Osteoclastogenesis.
Wang Z, Li Z, Wang G, Sun Y, Yuan Y, Nie H
International journal of molecular sciences 2021 Mar 28;22(7)
International journal of molecular sciences 2021 Mar 28;22(7)
Localization of the WD repeat-containing protein 5 to the Virion Assembly Compartment Facilitates Human Cytomegalovirus Assembly.
Yang B, Yao Y, Wu H, Yang H, Ma XH, Li D, Wang XZ, Huang SN, Jiang X, Cheng S, Sun JY, Huang ZL, Zhao C, McVoy MA, Ahn JH, Zeng WB, Britt WJ, Gong S, Luo MH
Journal of virology 2021 Mar 25;95(8)
Journal of virology 2021 Mar 25;95(8)
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Sun Y, He L, Wang W, Wang T, Hua W, Li T, Wang L, Gao T, Chen F, Tang L
Journal of ethnopharmacology 2021 Mar 25;268:113617
Journal of ethnopharmacology 2021 Mar 25;268:113617
Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways.
Guo C, Bi J, Li X, Lyu J, Liu X, Wu X, Liu J
Food chemistry 2021 Mar 15;340:127931
Food chemistry 2021 Mar 15;340:127931
MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation.
Che J, Xu C, Wu Y, Jia P, Han Q, Ma Y, Wang X, Zheng Y
Skeletal muscle 2021 Mar 15;11(1):6
Skeletal muscle 2021 Mar 15;11(1):6
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Feng J, Xie L, Yu X, Liu C, Dong H, Lu W, Kong R
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
Biochemical and biophysical research communications 2021 Mar 12;544:22-30
Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening.
Baxley RM, Leung W, Schmit MM, Matson JP, Yin L, Oram MK, Wang L, Taylor J, Hedberg J, Rogers CB, Harvey AJ, Basu D, Taylor JC, Pagnamenta AT, Dreau H, Craft J, Ormondroyd E, Watkins H, Hendrickson EA, Mace EM, Orange JS, Aihara H, Stewart GS, Blair E, Cook JG, Bielinsky AK
Nature communications 2021 Mar 12;12(1):1626
Nature communications 2021 Mar 12;12(1):1626
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Lu D, Le Y, Ding J, Dou X, Mao W, Zhu J
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus.
Chen L, Zhang J, Zou Y, Wang F, Li J, Sun F, Luo X, Zhang M, Guo Y, Yu Q, Yang P, Zhou Q, Chen Z, Zhang H, Gong Q, Zhao J, Eizirik DL, Zhou Z, Xiong F, Zhang S, Wang CY
Cell death and differentiation 2021 Jun;28(6):1880-1899
Cell death and differentiation 2021 Jun;28(6):1880-1899
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Li X, Wang X, Miao L, Liu Y, Lin X, Guo Y, Yuan R, Tian H
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Activation of yes-associated protein mediates sphingosine-1-phosphate-induced proliferation and migration of pulmonary artery smooth muscle cells and its potential mechanisms.
Shi W, Wang Q, Wang J, Yan X, Feng W, Zhang Q, Zhai C, Chai L, Li S, Xie X, Li M
Journal of cellular physiology 2021 Jun;236(6):4694-4708
Journal of cellular physiology 2021 Jun;236(6):4694-4708
miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.
Han S, Wang Z, Liu J, Wang HD, Yuan Q
Biochemical pharmacology 2021 Jun;188:114539
Biochemical pharmacology 2021 Jun;188:114539
T-17, a spirostanol saponin, inhibits p53-independent proliferation and p53-dependent migration of gastric cancer cells.
Xu J, Wang Y, Wang Z, Wang Y, He X
Steroids 2021 Jun;170:108828
Steroids 2021 Jun;170:108828
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
Hoshi M, Kubo H, Ando T, Tashita C, Nakamoto K, Yamamoto Y, Tezuka H, Saito K
ImmunoHorizons 2021 Jun 28;5(6):523-534
ImmunoHorizons 2021 Jun 28;5(6):523-534
SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells.
Xia S, Wu J, Zhou W, Zhang M, Zhao K, Liu J, Tian D, Liao J
Cell death & disease 2021 Jun 2;12(6):570
Cell death & disease 2021 Jun 2;12(6):570
Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells.
Liu Z, Zhu Q, Song E, Song Y
Toxicology 2021 Jun 15;457:152807
Toxicology 2021 Jun 15;457:152807
Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch.
Xi X, Zhao Y, Liu H, Li Z, Chen S, Liu D
Experimental cell research 2021 Jun 15;403(2):112598
Experimental cell research 2021 Jun 15;403(2):112598
Particulate matter promotes hyperpigmentation via AhR/MAPK signaling activation and by increasing α-MSH paracrine levels in keratinocytes.
Shi Y, Zeng Z, Liu J, Pi Z, Zou P, Deng Q, Ma X, Qiao F, Xiong W, Zhou C, Zeng Q, Xiao R
Environmental pollution (Barking, Essex : 1987) 2021 Jun 1;278:116850
Environmental pollution (Barking, Essex : 1987) 2021 Jun 1;278:116850
YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma.
Liu X, Chen D, Chen H, Wang W, Liu Y, Wang Y, Duan C, Ning Z, Guo X, Otkur W, Liu J, Qi H, Liu X, Lin A, Xia T, Liu HX, Piao HL
Cancer communications (London, England) 2021 Jul;41(7):576-595
Cancer communications (London, England) 2021 Jul;41(7):576-595
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Liu X, Li M, Zhu J, Huang W, Song J
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Human & experimental toxicology 2021 Jul;40(7):1095-1111
MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
Hu L, Yin C, Chen D, Wu Z, Liang S, Zhang Y, Huang Z, Liu S, Xu X, Chen Z, Zhang Y, Qian A
Cell death and differentiation 2021 Jul;28(7):2160-2178
Cell death and differentiation 2021 Jul;28(7):2160-2178
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L.
Zhang W, Zhang R, Zeng Y, Li Y, Chen Y, Zhou J, Zhang Y, Wang A, Zhu J, Liu Z, Yan Z, Huang JA
Cell death & disease 2021 Jul 31;12(8):755
Cell death & disease 2021 Jul 31;12(8):755
C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation.
Ye L, Jia G, Li Y, Wang Y, Chen H, Yu L, Wu D
Journal of neuroinflammation 2021 Jul 18;18(1):159
Journal of neuroinflammation 2021 Jul 18;18(1):159
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Che J, Xu C, Wu Y, Jia P, Han Q, Ma Y, Wang X, Du Y, Zheng Y
Life sciences 2021 Jul 15;277:119520
Life sciences 2021 Jul 15;277:119520
Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling.
Cao YY, Wang ZH, Xu QC, Chen Q, Wang Z, Lu WH
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Jul 1;25(4):375-383
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Jul 1;25(4):375-383
Iguratimod inhibits osteoclastogenesis by modulating the RANKL and TNF-α signaling pathways.
Li CH, Ma ZZ, Jian LL, Wang XY, Sun L, Liu XY, Yao ZQ, Zhao JX
International immunopharmacology 2021 Jan;90:107219
International immunopharmacology 2021 Jan;90:107219
Inhibition of miR-155 alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-κB signaling.
Cao YY, Wang Z, Wang ZH, Jiang XG, Lu WH
International immunopharmacology 2021 Jan;90:107218
International immunopharmacology 2021 Jan;90:107218
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Chen C, Gu J, Wang J, Wu Y, Yang A, Chen T, Zhou T, Liu Z
International immunopharmacology 2021 Jan;90:107206
International immunopharmacology 2021 Jan;90:107206
Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice.
Yang D, Xu D, Wang T, Yuan Z, Liu L, Shen Y, Wen F
International immunopharmacology 2021 Jan;90:107149
International immunopharmacology 2021 Jan;90:107149
Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.
Li X, Liu X, Deng R, Gao S, Jiang Q, Liu R, Li H, Miao Y, Zhai Y, Zhang S, Wang Z, Ren Y, Ning W, Zhou H, Yang C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153428
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153428
Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model.
Xu H, Qi Q, Yan X
Naunyn-Schmiedeberg's archives of pharmacology 2021 Jan;394(1):165-175
Naunyn-Schmiedeberg's archives of pharmacology 2021 Jan;394(1):165-175
Polychlorinated biphenyl quinone induced the acquisition of cancer stem cells properties and epithelial-mesenchymal transition through Wnt/β-catenin.
Qin Q, Yang B, Liu Z, Xu L, Song E, Song Y
Chemosphere 2021 Jan;263:128125
Chemosphere 2021 Jan;263:128125
Serotonin transporter regulation by cholesterol-independent lipid signaling.
Deveau CM, Rodriguez E, Schroering A, Yamamoto BK
Biochemical pharmacology 2021 Jan;183:114349
Biochemical pharmacology 2021 Jan;183:114349
P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.
Ji JZ, Li YF, Jiang LP, Tai T, Ge PX, Mi QY, Zhu T, Xie HG
Biochemical pharmacology 2021 Jan;183:114313
Biochemical pharmacology 2021 Jan;183:114313
Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma.
Jin J, Zhou M, Wang X, Liu M, Huang H, Yan F, Yu Z, Shu X, Huo X, Feng L, Zhang B, Huang S, Deng S, Wang C, Ma X
Fitoterapia 2021 Jan;148:104779
Fitoterapia 2021 Jan;148:104779
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway.
Liu K, Song J, Yan Y, Zou K, Che Y, Wang B, Li Z, Yu W, Guo W, Zou L, Deng W, Sun X
Translational oncology 2021 Jan;14(1):100876
Translational oncology 2021 Jan;14(1):100876
Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment.
McKinzey DR, Gomathinayagam S, Griffin WC, Klinzing KN, Jeffries EP, Rajkovic A, Trakselis MA
The Journal of biological chemistry 2021 Jan-Jun;296:100355
The Journal of biological chemistry 2021 Jan-Jun;296:100355
NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway.
Yu S, Wang Y, Lv K, Hou J, Li W, Wang X, Guo H, Wang W
Technology in cancer research & treatment 2021 Jan-Dec;20:15330338211027916
Technology in cancer research & treatment 2021 Jan-Dec;20:15330338211027916
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.
Zhang W, Yin G, Zhao H, Ling H, Xie Z, Xiao C, Chen Y, Lin Y, Jiang T, Jin S, Wang J, Yang X
Cell death & disease 2021 Jan 20;12(1):102
Cell death & disease 2021 Jan 20;12(1):102
Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.
Duan S, Li H, Zhang Y, Yang S, Chen Y, Qiu B, Huang C, Wang J, Li J, Zhu X, Yan X
The EMBO journal 2021 Jan 15;40(2):e105499
The EMBO journal 2021 Jan 15;40(2):e105499
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y
Life sciences 2021 Jan 15;265:118796
Life sciences 2021 Jan 15;265:118796
Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1.
Zong X, Xiao X, Kai L, Cheng Y, Fu J, Xu W, Wang Y, Zhao K, Jin M
International journal of biological macromolecules 2021 Jan 15;167:76-84
International journal of biological macromolecules 2021 Jan 15;167:76-84
Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1.
Kuan MI, Jaeger HK, Balemba OB, O'Dowd JM, Duricka D, Hannemann H, Marx E, Teissier N, Gabrielli L, Bonasoni MP, Keithley EM, Fortunato EA
Journal of virology 2021 Jan 13;95(3)
Journal of virology 2021 Jan 13;95(3)
Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells.
Zhao N, Dong W, Kim H, Moallemian R, Lv J, Wang H, Zheng H, Wei F, Ma X
Cellular signalling 2021 Feb;78:109848
Cellular signalling 2021 Feb;78:109848
Gastrin-17 induces gastric cancer cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
Li Y, Zhao Y, Li Y, Zhang X, Li C, Long N, Chen X, Bao L, Zhou J, Xie Y
Journal of physiology and biochemistry 2021 Feb;77(1):93-104
Journal of physiology and biochemistry 2021 Feb;77(1):93-104
Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response.
Roth LM, Zidane B, Festa L, Putatunda R, Romer M, Monnerie H, Jordan-Sciutto KL, Grinspan JB
Glia 2021 Feb;69(2):362-376
Glia 2021 Feb;69(2):362-376
The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
Ke W, Wang B, Hua W, Song Y, Lu S, Luo R, Li G, Wang K, Liao Z, Xiang Q, Li S, Wu X, Zhang Y, Yang C
Cell proliferation 2021 Feb;54(2):e12987
Cell proliferation 2021 Feb;54(2):e12987
LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior.
Naetar N, Georgiou K, Knapp C, Bronshtein I, Zier E, Fichtinger P, Dechat T, Garini Y, Foisner R
eLife 2021 Feb 19;10
eLife 2021 Feb 19;10
A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.
Noguchi T, Hidaka K, Kobayashi S, Matsumoto K, Yoshioka M, Hu X, Maloney DJ, Yang SM, Kato S
Drug development research 2021 Dec;82(8):1235-1246
Drug development research 2021 Dec;82(8):1235-1246
Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model.
Tanigawa S, Fujita M, Moyama C, Ando S, Ii H, Kojima Y, Fujishita T, Aoki M, Takeuchi H, Yamanaka T, Takahashi Y, Hashimoto N, Nakata S
Cancer gene therapy 2021 Dec;28(12):1339-1352
Cancer gene therapy 2021 Dec;28(12):1339-1352
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases.
Zhong S, Lian Y, Luo W, Luo R, Wu X, Ji J, Ji Y, Ding J, Wang X
Acta neuropathologica 2021 Dec;142(6):1003-1023
Acta neuropathologica 2021 Dec;142(6):1003-1023
α-Actinin1 promotes tumorigenesis and epithelial-mesenchymal transition of gastric cancer via the AKT/GSK3β/β-Catenin pathway.
Zhang S, Wang J, Chen T, Wang J, Wang Y, Yu Z, Zhao K, Zheng K, Chen Y, Wang Z, Li B, Wang C, Huang W, Fu Z, Chen J
Bioengineered 2021 Dec;12(1):5688-5704
Bioengineered 2021 Dec;12(1):5688-5704
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
Zhang L, Zhu T, He F, Li X
International immunopharmacology 2021 Dec;101(Pt B):108238
International immunopharmacology 2021 Dec;101(Pt B):108238
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
Zhu F, Shao J, Tian Y, Xu Z
International immunopharmacology 2021 Dec;101(Pt B):108221
International immunopharmacology 2021 Dec;101(Pt B):108221
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F
Journal of neuroinflammation 2021 Dec 20;18(1):295
Journal of neuroinflammation 2021 Dec 20;18(1):295
The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression.
Li X, Yuan B, Lu M, Wang Y, Ding N, Liu C, Gao M, Yao Z, Zhang S, Zhao Y, Xie L, Chen Z
Nature communications 2021 Dec 10;12(1):7213
Nature communications 2021 Dec 10;12(1):7213
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Cao P, Yang A, Li P, Xia X, Han Y, Zhou G, Wang R, Yang F, Li Y, Zhang Y, Cui Y, Ji H, Lu L, He F, Zhou G
Science advances 2021 Aug;7(35)
Science advances 2021 Aug;7(35)
Establishment of a GFP::LMNB1 knockin cell line (CSUi002-A-1) from a dystonia patient-specific iPSC by CRISPR/Cas9 editing.
Tang Y, Ren J, Li CC
Stem cell research 2021 Aug;55:102505
Stem cell research 2021 Aug;55:102505
Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP.
Zhang Q, Li W, Zhu Y, Wang Q, Zhai C, Shi W, Feng W, Wang J, Yan X, Chai L, Chen Y, Li C, Liu P, Li M
Molecular and cellular biochemistry 2021 Aug;476(8):3037-3049
Molecular and cellular biochemistry 2021 Aug;476(8):3037-3049
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Ma X, Zhang J, Wu Z, Wang X
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway.
Zhang H, Chi M, Chen L, Sun X, Wan L, Yang Q, Guo C
Phytotherapy research : PTR 2021 Aug;35(8):4363-4376
Phytotherapy research : PTR 2021 Aug;35(8):4363-4376
Fenofibrate inhibits TGF-β-induced myofibroblast differentiation and activation in human lung fibroblasts in vitro.
Kikuchi R, Maeda Y, Tsuji T, Yamaguchi K, Abe S, Nakamura H, Aoshiba K
FEBS open bio 2021 Aug;11(8):2340-2349
FEBS open bio 2021 Aug;11(8):2340-2349
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Li J, Wang S, Wang N, Zheng Y, Yang B, Wang X, Zhang J, Pan B, Wang Z
Cell communication and signaling : CCS 2021 Aug 30;19(1):89
Cell communication and signaling : CCS 2021 Aug 30;19(1):89
UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma.
Zhu J, Ao H, Liu M, Cao K, Ma J
Journal of translational medicine 2021 Aug 30;19(1):374
Journal of translational medicine 2021 Aug 30;19(1):374
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Zhao Y, Lu J, Mao A, Zhang R, Guan S
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Repeated neonatal sevoflurane induced neurocognitive impairment through NF-κB-mediated pyroptosis.
Dai J, Li X, Wang C, Gu S, Dai L, Zhang J, Fan Y, Wu J
Journal of neuroinflammation 2021 Aug 21;18(1):180
Journal of neuroinflammation 2021 Aug 21;18(1):180
Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
Ge PX, Jiang LP, Tai T, Zhu T, Ji JZ, Li YF, Mi QY, Xie HG
Life sciences 2021 Aug 15;279:119268
Life sciences 2021 Aug 15;279:119268
KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer.
Lu D, Song Y, Yu Y, Wang D, Liu B, Chen L, Li X, Li Y, Cheng L, Lv F, Zhang P, Xing Y
Cell death & disease 2021 Aug 12;12(8):787
Cell death & disease 2021 Aug 12;12(8):787
Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice.
Tang XL, Wang X, Fang G, Zhao YL, Yan J, Zhou Z, Sun R, Luo AL, Li SY
The Journal of nutritional biochemistry 2021 Apr;90:108579
The Journal of nutritional biochemistry 2021 Apr;90:108579
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis.
Chibaatar E, Le K, Abdoulaye IA, Wu S, Guo Y
Journal of molecular neuroscience : MN 2021 Apr;71(4):691-701
Journal of molecular neuroscience : MN 2021 Apr;71(4):691-701
Pseudoginsenoside F11 ameliorates the dysfunction of the autophagy-lysosomal pathway by activating calcineurin-mediated TFEB nuclear translocation in neuron during permanent cerebral ischemia.
Fu X, Liu Y, Zhang H, Yu X, Wang X, Wu C, Yang J
Experimental neurology 2021 Apr;338:113598
Experimental neurology 2021 Apr;338:113598
KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway.
Du W, Zhu J, Zeng Y, Liu T, Zhang Y, Cai T, Fu Y, Zhang W, Zhang R, Liu Z, Huang JA
Cell death and differentiation 2021 Apr;28(4):1284-1300
Cell death and differentiation 2021 Apr;28(4):1284-1300
Myricetin protects against H(2) O(2) -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Kan X, Liu J, Chen Y, Guo W, Xu D, Cheng J, Cao Y, Yang Z, Fu S
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Journal of cellular physiology 2021 Apr;236(4):2684-2695
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L
Food & function 2021 Apr 7;12(7):3120-3131
Food & function 2021 Apr 7;12(7):3120-3131
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
Guo G, Gao M, Gao X, Zhu B, Huang J, Tu X, Kim W, Zhao F, Zhou Q, Zhu S, Wu Z, Yan Y, Zhang Y, Zeng X, Zhu Q, Yin P, Luo K, Sun J, Deng M, Lou Z
Nature communications 2021 Apr 12;12(1):2187
Nature communications 2021 Apr 12;12(1):2187
RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration.
Shao Z, Tu Z, Shi Y, Li S, Wu A, Wu Y, Tian N, Sun L, Pan Z, Chen L, Gao W, Zhou Y, Wang X, Zhang X
Frontiers in cell and developmental biology 2020;8:611234
Frontiers in cell and developmental biology 2020;8:611234
LncRNA AC010789.1 Promotes Colorectal Cancer Progression by Targeting MicroRNA-432-3p/ZEB1 Axis and the Wnt/β-Catenin Signaling Pathway.
Duan W, Kong X, Li J, Li P, Zhao Y, Liu T, Binang HB, Wang Y, Du L, Wang C
Frontiers in cell and developmental biology 2020;8:565355
Frontiers in cell and developmental biology 2020;8:565355
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, Chi T, Zou L, Wang S, He Z
Oxidative medicine and cellular longevity 2020;2020:7950457
Oxidative medicine and cellular longevity 2020;2020:7950457
Effects of Saccharides from Arctium lappa L. Root on FeCl(3)-Induced Arterial Thrombosis via the ERK/NF-κB Signaling Pathway.
Qiu T, Zhou H, Li S, Tian N, Li Z, Wang R, Sun P, Peng J, Du J, Ma X, Diao Y, Lv L, Wang L, Li H
Oxidative medicine and cellular longevity 2020;2020:7691352
Oxidative medicine and cellular longevity 2020;2020:7691352
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Tian TT, Li QR, Gan SQ, Chang CR, Shen XC
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats.
Yu J, Wang WN, Matei N, Li X, Pang JW, Mo J, Chen SP, Tang JP, Yan M, Zhang JH
Oxidative medicine and cellular longevity 2020;2020:4717258
Oxidative medicine and cellular longevity 2020;2020:4717258
Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.
Zavaczki E, Gáll T, Zarjou A, Hendrik Z, Potor L, Tóth CZ, Méhes G, Gyetvai Á, Agarwal A, Balla G, Balla J
Oxidative medicine and cellular longevity 2020;2020:3721383
Oxidative medicine and cellular longevity 2020;2020:3721383
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Du J, He W, Zhang C, Wu J, Li Z, Wang M, Feng S, Liang G
BioMed research international 2020;2020:3243906
BioMed research international 2020;2020:3243906
Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation.
Jin M, Feng H, Wang Y, Yan S, Shen B, Li Z, Qin H, Wang Q, Li J, Liu G
Oxidative medicine and cellular longevity 2020;2020:2940746
Oxidative medicine and cellular longevity 2020;2020:2940746
Autophagy Contributes to the Maintenance of Genomic Integrity by Reducing Oxidative Stress.
Bu W, Hao X, Yang T, Wang J, Liu Q, Zhang X, Li X, Gong Y, Shao C
Oxidative medicine and cellular longevity 2020;2020:2015920
Oxidative medicine and cellular longevity 2020;2020:2015920
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Wang H, Jiang Z, Pang Z, Zhou T, Gu Y
Drug design, development and therapy 2020;14:4801-4813
Drug design, development and therapy 2020;14:4801-4813
Reduced hydration-induced decreased caveolin-1 expression causes epithelial-to-mesenchymal transition.
Yang S, Zhao J, Huang S, Shu B, Yang R, Chen L, Xu Y, Xie J, Liu X, Jia J, Qi S
American journal of translational research 2020;12(12):8067-8083
American journal of translational research 2020;12(12):8067-8083
Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma.
Zhu G, Li X, Li J, Zhou W, Chen Z, Fan Y, Jiang Y, Zhao Y, Sun G, Mao W
Journal of Cancer 2020;11(22):6516-6529
Journal of Cancer 2020;11(22):6516-6529
Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo.
Wu Y, Wang Z, Lin Z, Fu X, Zhan J, Yu K
Frontiers in pharmacology 2020;11:682
Frontiers in pharmacology 2020;11:682
Linalool Prevents Cisplatin Induced Muscle Atrophy by Regulating IGF-1/Akt/FoxO Pathway.
Zhang H, Chi M, Chen L, Sun X, Wan L, Yang Q, Guo C
Frontiers in pharmacology 2020;11:598166
Frontiers in pharmacology 2020;11:598166
Repositioning an Immunomodulatory Drug Vidofludimus as a Farnesoid X Receptor Modulator With Therapeutic Effects on NAFLD.
Zhu Y, Xu S, Lu Y, Wei Y, Yao B, Guo F, Zheng X, Wang Y, He Y, Jin L, Li Y
Frontiers in pharmacology 2020;11:590
Frontiers in pharmacology 2020;11:590
Lycopene Exerts Neuroprotective Effects After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the Nuclear Factor Erythroid-2 Related Factor 2/Nuclear Factor-κ-Gene Binding Pathway.
Fu C, Zheng Y, Zhu J, Chen B, Lin W, Lin K, Zhu J, Chen S, Li P, Fu X, Lin Z
Frontiers in pharmacology 2020;11:585898
Frontiers in pharmacology 2020;11:585898
Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins.
Zhang X, Lin X, Qin C, Huang K, Sun X, Zhao L, Jin M
Frontiers in microbiology 2020;11:538355
Frontiers in microbiology 2020;11:538355
Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway.
Li X, Liu X, Deng R, Gao S, Yu H, Huang K, Jiang Q, Liu R, Li X, Zhang L, Zhou H, Yang C
Frontiers in pharmacology 2020;11:310
Frontiers in pharmacology 2020;11:310
Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication.
Li C, Wang L, Liu J, Yu Y, Huang Y, Huang X, Wei J, Qin Q
Frontiers in microbiology 2020;11:1446
Frontiers in microbiology 2020;11:1446
SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma.
Xu H, Wang H, Zhao W, Fu S, Li Y, Ni W, Xin Y, Li W, Yang C, Bai Y, Zhan M, Lu L
Theranostics 2020;10(13):5671-5686
Theranostics 2020;10(13):5671-5686
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
Wu Y, Wang Z, Fu X, Lin Z, Yu K
International immunopharmacology 2020 Sep;86:106713
International immunopharmacology 2020 Sep;86:106713
ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3.
Li YL, Wu LW, Zeng LH, Zhang ZY, Wang W, Zhang C, Lin NM
Oncogene 2020 Sep;39(39):6203-6217
Oncogene 2020 Sep;39(39):6203-6217
Tacrolimus ameliorates tubulointerstitial inflammation in diabetic nephropathy via inhibiting the NFATc1/TRPC6 pathway.
Zhang S, Wang H, Liu Y, Yang W, Liu J, Han Y, Liu Y, Liu F, Sun L, Xiao L
Journal of cellular and molecular medicine 2020 Sep;24(17):9810-9824
Journal of cellular and molecular medicine 2020 Sep;24(17):9810-9824
Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.
Zhou Y, Han C, Wang E, Lorch AH, Serafin V, Cho BK, Gutierrez Diaz BT, Calvo J, Fang C, Khodadadi-Jamayran A, Tabaglio T, Marier C, Kuchmiy A, Sun L, Yacu G, Filip SK, Jin Q, Takahashi YH, Amici DR, Rendleman EJ, Rawat R, Bresolin S, Paganin M, Zhang C, Li H, Kandela I, Politanska Y, Abdala-Valencia H, Mendillo ML, Zhu P, Palhais B, Van Vlierberghe P, Taghon T, Aifantis I, Goo YA, Guccione E, Heguy A, Tsirigos A, Wee KB, Mishra RK, Pflumio F, Accordi B, Basso G, Ntziachristos P
Cancer discovery 2020 Sep;10(9):1388-1409
Cancer discovery 2020 Sep;10(9):1388-1409
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Sivalingam K, Samikkannu T
Brain sciences 2020 Sep 5;10(9)
Brain sciences 2020 Sep 5;10(9)
Circular RNA GLIS2 promotes colorectal cancer cell motility via activation of the NF-κB pathway.
Chen J, Yang X, Liu R, Wen C, Wang H, Huang L, Li W, Zhu Z, Zhu Y, Liu H
Cell death & disease 2020 Sep 23;11(9):788
Cell death & disease 2020 Sep 23;11(9):788
Facile Cholesterol Loading with a New Probe ezFlux Allows for Streamlined Cholesterol Efflux Assays.
Ravodina AM, Badgeley MA, Rajagopalan S, Fedyukina DV, Maiseyeu A
ACS omega 2020 Sep 15;5(36):23289-23298
ACS omega 2020 Sep 15;5(36):23289-23298
Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies.
Mackie BD, Chen D, Dong G, Dong C, Parker H, Schaner Tooley CE, Noinaj N, Min J, Huang R
Journal of medicinal chemistry 2020 Sep 10;63(17):9512-9522
Journal of medicinal chemistry 2020 Sep 10;63(17):9512-9522
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Zhang B, Yu D, Luo N, Yang C, Zhu Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.
Zhao L, Li R, Qiu JZ, Yu JB, Cao Y, Yuan RT
Molecular and cellular probes 2020 Oct;53:101577
Molecular and cellular probes 2020 Oct;53:101577
Down-regulation of exosomal miR-200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis.
Zhao C, Wang D, Wang X, Mao Y, Xu Z, Sun Y, Mei X, Song J, Shi W
Journal of cellular and molecular medicine 2020 Oct;24(20):12164-12175
Journal of cellular and molecular medicine 2020 Oct;24(20):12164-12175
RNA demethylase Alkbh5 is widely expressed in neurons and decreased during brain development.
Du T, Li G, Yang J, Ma K
Brain research bulletin 2020 Oct;163:150-159
Brain research bulletin 2020 Oct;163:150-159
Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation.
Han B, Wang K, Tu Y, Tan L, He C
Dose-response : a publication of International Hormesis Society 2020 Oct-Dec;18(4):1559325820939751
Dose-response : a publication of International Hormesis Society 2020 Oct-Dec;18(4):1559325820939751
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
Shao Z, Pan Z, Lin J, Zhao Q, Wang Y, Ni L, Feng S, Tian N, Wu Y, Sun L, Gao W, Zhou Y, Zhang X, Wang X
Aging 2020 Oct 7;12(19):19254-19272
Aging 2020 Oct 7;12(19):19254-19272
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
Zohud BA, Guo P, Zohud BA, Li F, Hao JJ, Shan X, Yu W, Guo W, Qin Y, Cai X
Cell death & disease 2020 Oct 20;11(10):879
Cell death & disease 2020 Oct 20;11(10):879
Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis.
Wang Y, Kong W, Wang L, Zhang T, Huang B, Meng J, Yang B, Xie Z, Zhou H
International journal of molecular sciences 2020 Oct 18;21(20)
International journal of molecular sciences 2020 Oct 18;21(20)
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Li Y, Wu J, Yu S, Zhu J, Zhou Y, Wang P, Li L, Zhao Y
Brain research 2020 Oct 15;1745:146948
Brain research 2020 Oct 15;1745:146948
Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production.
Zhang W, Xiong H, Pang J, Su Z, Lai L, Lin H, Jian B, He W, Yang H, Zheng Y
Toxicology letters 2020 Oct 1;331:1-10
Toxicology letters 2020 Oct 1;331:1-10
Aryl hydrocarbon receptor signaling activation in systemic sclerosis attenuates collagen production and is a potential antifibrotic target.
Shi Y, Tang B, Yu J, Luo Y, Xiao Y, Pi Z, Tang R, Wang Y, Kanekura T, Zeng Z, Xiao R
International immunopharmacology 2020 Nov;88:106886
International immunopharmacology 2020 Nov;88:106886
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
Yu ZY, Jiang XY, Zhao RR, Luo CJ, Ren YX, Ma ZJ, Ye HL, Shi WG, Wang C, Jiao ZY
Neoplasma 2020 Nov;67(6):1303-1313
Neoplasma 2020 Nov;67(6):1303-1313
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Sun Y, He L, Wang T, Hua W, Qin H, Wang J, Wang L, Gu W, Li T, Li N, Liu X, Chen F, Tang L
Molecular neurobiology 2020 Nov;57(11):4628-4641
Molecular neurobiology 2020 Nov;57(11):4628-4641
Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.
Liu S, Gao Y, Zhang L, Yin Y, Zhang W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):14946-14959
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):14946-14959
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Lee DH, Park JS, Lee YS, Han J, Lee DK, Kwon SW, Han DH, Lee YH, Bae SH
Autophagy 2020 Nov;16(11):1949-1973
Autophagy 2020 Nov;16(11):1949-1973
Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence.
Isermann A, Mann C, Rübe CE
International journal of molecular sciences 2020 Nov 30;21(23)
International journal of molecular sciences 2020 Nov 30;21(23)
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Ding S, Ma N, Liu H, Tang M, Mei J
Aging 2020 Nov 24;12(24):25505-25527
Aging 2020 Nov 24;12(24):25505-25527
Pin1 promotes pancreatic cancer progression and metastasis by activation of NF-κB-IL-18 feedback loop.
Sun Q, Fan G, Zhuo Q, Dai W, Ye Z, Ji S, Xu W, Liu W, Hu Q, Zhang Z, Liu M, Yu X, Xu X, Qin Y
Cell proliferation 2020 May;53(5):e12816
Cell proliferation 2020 May;53(5):e12816
DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.
Luo W, Zhang H, Liang X, Xia R, Deng H, Yi Q, Lv L, Qian L
Oncology reports 2020 May;43(5):1692-1704
Oncology reports 2020 May;43(5):1692-1704
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
Yu YP, Cai LC, Wang XY, Cheng SY, Zhang DM, Jian WG, Wang TD, Yang JK, Yang KB, Zhang C
Cancer science 2020 May;111(5):1555-1566
Cancer science 2020 May;111(5):1555-1566
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
Cai Z, Zhang MX, Tang Z, Zhang Q, Ye J, Xiong TC, Zhang ZD, Zhong B
The Journal of experimental medicine 2020 May 4;217(5)
The Journal of experimental medicine 2020 May 4;217(5)
Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/ Polyps with Dysplasia.
Fujiwara-Tani R, Fujii K, Mori S, Kishi S, Sasaki T, Ohmori H, Nakashima C, Kawahara I, Nishiguchi Y, Mori T, Sho M, Kondoh M, Luo Y, Kuniyasu H
International journal of molecular sciences 2020 May 28;21(11)
International journal of molecular sciences 2020 May 28;21(11)
Regulation of a PRMT5/NF-κB Axis by Phosphorylation of PRMT5 at Serine 15 in Colorectal Cancer.
Hartley AV, Wang B, Jiang G, Wei H, Sun M, Prabhu L, Martin M, Safa A, Sun S, Liu Y, Lu T
International journal of molecular sciences 2020 May 23;21(10)
International journal of molecular sciences 2020 May 23;21(10)
Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice.
Huang H, Cai H, Zhang L, Hua Z, Shi J, Wei Y
International immunopharmacology 2020 Mar;80:106123
International immunopharmacology 2020 Mar;80:106123
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Cell proliferation 2020 Mar;53(3):e12779
Cell proliferation 2020 Mar;53(3):e12779
AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics.
Qi M, Dai D, Liu J, Li Z, Liang P, Wang Y, Cheng L, Zhan Y, An Z, Song Y, Yang Y, Yan X, Xiao H, Shao H
Oncogene 2020 Mar;39(13):2707-2723
Oncogene 2020 Mar;39(13):2707-2723
Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury.
Li Z, Feng H, Han L, Ding L, Shen B, Tian Y, Zhao L, Jin M, Wang Q, Qin H, Cheng J, Liu G
Journal of cellular and molecular medicine 2020 Mar;24(5):3022-3033
Journal of cellular and molecular medicine 2020 Mar;24(5):3022-3033
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.
Li ST, Huang D, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X, Zhang H, Gao P
Nature metabolism 2020 Mar;2(3):256-269
Nature metabolism 2020 Mar;2(3):256-269
Nuclear-localized costimulatory molecule 4-1BBL promotes colon cancer cell proliferation and migration by regulating nuclear Gsk3β, and is linked to the poor outcomes associated with colon cancer.
Ge Y, Chen W, Zhang X, Wang H, Cui J, Liu Y, Ju S, Tian X, Ju S
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):577-591
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):577-591
Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression.
Shanley KL, Hu CL, Bizzozero OA
Journal of neurochemistry 2020 Mar;152(5):585-601
Journal of neurochemistry 2020 Mar;152(5):585-601
[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].
Wu CF, Xiao M, Wang YL, Threadgill MD, Li M, Tang Y, Lin X, Yang L, Li QS, Li X
Molekuliarnaia biologiia 2020 Mar-Apr;54(2):252-261
Molekuliarnaia biologiia 2020 Mar-Apr;54(2):252-261
Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.
Zuo Y, Feng Q, Jin L, Huang F, Miao Y, Liu J, Xu Y, Chen X, Zhang H, Guo T, Yuan Y, Zhang L, Wang J, Zheng H
Nature communications 2020 Mar 2;11(1):1146
Nature communications 2020 Mar 2;11(1):1146
Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin.
Le K, Wu S, Chibaatar E, Ali AI, Guo Y
ACS chemical neuroscience 2020 Mar 18;11(6):979-993
ACS chemical neuroscience 2020 Mar 18;11(6):979-993
AEBP1 Promotes the Occurrence and Development of Abdominal Aortic Aneurysm by Modulating Inflammation via the NF-κB Pathway.
Ren J, Han Y, Ren T, Fang H, Xu X, Lun Y, Jiang H, Xin S, Zhang J
Journal of atherosclerosis and thrombosis 2020 Mar 1;27(3):255-270
Journal of atherosclerosis and thrombosis 2020 Mar 1;27(3):255-270
1,25-Dihydroxyvitamin D attenuates diabetic cardiac autophagy and damage by vitamin D receptor-mediated suppression of FoxO1 translocation.
Guo X, Lin H, Liu J, Wang D, Li D, Jiang C, Tang Y, Wang J, Zhang T, Li Y, Yao P
The Journal of nutritional biochemistry 2020 Jun;80:108380
The Journal of nutritional biochemistry 2020 Jun;80:108380
Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.
Luo X, Li Y, Yang P, Chen Y, Wei L, Yu T, Xia J, Ruan XZ, Zhao L, Chen Y
EBioMedicine 2020 Jun;56:102797
EBioMedicine 2020 Jun;56:102797
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W
Aging cell 2020 Jun;19(6):e13163
Aging cell 2020 Jun;19(6):e13163
Novel role of ASH1L histone methyltransferase in anaplastic thyroid carcinoma.
Xu B, Qin T, Yu J, Giordano TJ, Sartor MA, Koenig RJ
The Journal of biological chemistry 2020 Jun 26;295(26):8834-8845
The Journal of biological chemistry 2020 Jun 26;295(26):8834-8845
RGS12 Is a Novel Critical NF-κB Activator in Inflammatory Arthritis.
Yuan G, Yang S, Ng A, Fu C, Oursler MJ, Xing L, Yang S
iScience 2020 Jun 26;23(6):101172
iScience 2020 Jun 26;23(6):101172
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
You R, Zhou W, Li Y, Zhang Y, Huang S, Jia Z, Zhang A
Clinical science (London, England : 1979) 2020 Jun 26;134(12):1357-1376
Clinical science (London, England : 1979) 2020 Jun 26;134(12):1357-1376
YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.
Cui Y, Li F, Xie Q, Zhao S, Guo T, Guo P, Hu S, Hao J, Tian C, Yu W, Li Z, Fang L, Zhao L, Chen M, Wu T, Gu C
Cell death & disease 2020 Jun 19;11(6):476
Cell death & disease 2020 Jun 19;11(6):476
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, Wu D, Ji X
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
SIRT2 suppresses expression of inflammatory factors via Hsp90-glucocorticoid receptor signalling.
Sun K, Wang X, Fang N, Xu A, Lin Y, Zhao X, Nazarali AJ, Ji S
Journal of cellular and molecular medicine 2020 Jul;24(13):7439-7450
Journal of cellular and molecular medicine 2020 Jul;24(13):7439-7450
The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
Zhong X, Feng L, Xu WH, Wu X, Ding YD, Zhou Y, Lei CQ, Shu HB
Cellular & molecular immunology 2020 Jul;17(7):741-752
Cellular & molecular immunology 2020 Jul;17(7):741-752
Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction.
Posta N, Csősz É, Oros M, Pethő D, Potor L, Kalló G, Hendrik Z, Sikura KÉ, Méhes G, Tóth C, Posta J, Balla G, Balla J
Laboratory investigation; a journal of technical methods and pathology 2020 Jul;100(7):986-1002
Laboratory investigation; a journal of technical methods and pathology 2020 Jul;100(7):986-1002
EN2 as an oncogene promotes tumor progression via regulating CCL20 in colorectal cancer.
Li Y, Liu J, Xiao Q, Tian R, Zhou Z, Gan Y, Li Y, Shu G, Yin G
Cell death & disease 2020 Jul 30;11(7):604
Cell death & disease 2020 Jul 30;11(7):604
Deficiency of microRNA-628-5p promotes the progression of gastric cancer by upregulating PIN1.
Chen Y, Wu Y, Yu S, Yang H, Wang X, Zhang Y, Zhu S, Jie M, Liu C, Li X, Zhou Y, Yang S, Yang Y
Cell death & disease 2020 Jul 23;11(7):559
Cell death & disease 2020 Jul 23;11(7):559
Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia.
Zhao X, Shi Y, Zhang D, Tong X, Sun Y, Xue X, Fu J
Life sciences 2020 Jul 1;252:117662
Life sciences 2020 Jul 1;252:117662
Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling.
Yen WC, Wu YH, Wu CC, Lin HR, Stern A, Chen SH, Shu JC, Tsun-Yee Chiu D
Redox biology 2020 Jan;28:101363
Redox biology 2020 Jan;28:101363
Poly (ADP-ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation-associated chemotherapy-induced autophagy in leukaemia cells.
Li Y, Xie J, Li X, Fang J
Oncology letters 2020 Jan;19(1):368-378
Oncology letters 2020 Jan;19(1):368-378
USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
Liu J, Jin L, Chen X, Yuan Y, Zuo Y, Miao Y, Feng Q, Zhang H, Huang F, Guo T, Zhang L, Zhu L, Qian F, Zhu C, Zheng H
PLoS pathogens 2020 Jan;16(1):e1008215
PLoS pathogens 2020 Jan;16(1):e1008215
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Park JS, Lee DH, Lee YS, Oh E, Bae KH, Oh KJ, Kim H, Bae SH
Autophagy 2020 Jan;16(1):86-105
Autophagy 2020 Jan;16(1):86-105
Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells.
Li GH, Li AL, Chen XM, Zhang LY, Wang T, Wang XN, Shen T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109669
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109669
The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry.
Wang G, Jiang L, Wang J, Zhang J, Kong F, Li Q, Yan Y, Huang S, Zhao Y, Liang L, Li J, Sun N, Hu Y, Shi W, Deng G, Chen P, Liu L, Zeng X, Tian G, Bu Z, Chen H, Li C
Journal of virology 2020 Jan 6;94(2)
Journal of virology 2020 Jan 6;94(2)
Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter.
Jiang W, Yan Y, Chen M, Luo G, Hao J, Pan J, Hu S, Guo P, Li W, Wang R, Zuo Y, Sun Y, Sui S, Yu W, Pan Z, Zou K, Zheng Z, Deng W, Wu X, Guo W
Aging 2020 Jan 6;12(1):611-627
Aging 2020 Jan 6;12(1):611-627
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
He X, Chen S, Li C, Ban J, Wei Y, He Y, Liu F, Chen Y, Chen J
Cells 2020 Jan 4;9(1)
Cells 2020 Jan 4;9(1)
Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas.
Nakashima C, Yamamoto K, Kishi S, Sasaki T, Ohmori H, Fujiwara-Tani R, Mori S, Kawahara I, Nishiguchi Y, Mori T, Kondoh M, Luo Y, Kirita T, Kuniyasu H
Oncotarget 2020 Jan 28;11(4):309-321
Oncotarget 2020 Jan 28;11(4):309-321
Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.
Burrus CJ, McKinstry SU, Kim N, Ozlu MI, Santoki AV, Fang FY, Ma A, Karadeniz YB, Worthington AK, Dragatsis I, Zeitlin S, Yin HH, Eroglu C
Cell reports 2020 Jan 21;30(3):642-657.e6
Cell reports 2020 Jan 21;30(3):642-657.e6
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Xu A, Yang Y, Shao Y, Wu M, Sun Y
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Xiao J, Li W, Zheng X, Qi L, Wang H, Zhang C, Wan X, Zheng Y, Zhong R, Zhou X, Lu Y, Li Z, Qiu Y, Liu C, Zhang F, Zhang Y, Xu X, Yang Z, Chen H, Zhai Q, Wei B, Wang H
Immunity 2020 Jan 14;52(1):109-122.e6
Immunity 2020 Jan 14;52(1):109-122.e6
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
He H, Xu C, Zheng L, Wang K, Jin M, Sun Y, Yue Z
Molecular medicine reports 2020 Feb;21(2):597-606
Molecular medicine reports 2020 Feb;21(2):597-606
Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease.
Sikura KÉ, Potor L, Szerafin T, Oros M, Nagy P, Méhes G, Hendrik Z, Zarjou A, Agarwal A, Posta N, Torregrossa R, Whiteman M, Fürtös I, Balla G, Balla J
British journal of pharmacology 2020 Feb;177(4):793-809
British journal of pharmacology 2020 Feb;177(4):793-809
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.
Ding XY, Hu HY, Huang KN, Wei RQ, Min J, Qi C, Tang H, Qin X
Cancer science 2020 Feb;111(2):489-501
Cancer science 2020 Feb;111(2):489-501
A DNAH17 missense variant causes flagella destabilization and asthenozoospermia.
Zhang B, Ma H, Khan T, Ma A, Li T, Zhang H, Gao J, Zhou J, Li Y, Yu C, Bao J, Ali A, Murtaza G, Yin H, Gao Q, Jiang X, Zhang F, Liu C, Khan I, Zubair M, Hussain HMJ, Khan R, Yousaf A, Yuan L, Lu Y, Xu X, Wang Y, Tao Q, Hao Q, Fang H, Cheng H, Zhang Y, Shi Q
The Journal of experimental medicine 2020 Feb 3;217(2)
The Journal of experimental medicine 2020 Feb 3;217(2)
UBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma.
Zhang GC, Yu XN, Sun JL, Xiong J, Yang YJ, Jiang XM, Zhu JM
Aging 2020 Feb 3;12(3):2373-2392
Aging 2020 Feb 3;12(3):2373-2392
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Life sciences 2020 Feb 15;243:117244
Life sciences 2020 Feb 15;243:117244
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
Wang Q, Shi W, Zhang Q, Feng W, Wang J, Zhai C, Yan X, Li M
Life sciences 2020 Feb 1;242:117159
Life sciences 2020 Feb 1;242:117159
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Lang L, Xu B, Yuan J, Li S, Lian S, Chen Y, Guo J, Yang H
International immunopharmacology 2020 Dec;89(Pt B):106908
International immunopharmacology 2020 Dec;89(Pt B):106908
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl(4)-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Zhang X, Feng J, Su S, Huang L
Pharmaceutical biology 2020 Dec;58(1):239-246
Pharmaceutical biology 2020 Dec;58(1):239-246
Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-κB pathway.
Yu T, Dong D, Guan J, Sun J, Guo M, Wang Q
Herz 2020 Dec;45(Suppl 1):130-138
Herz 2020 Dec;45(Suppl 1):130-138
Promotion of esophageal adenocarcinoma metastasis via Wnt/ß-catenin signal pathway by sorting nexins 3.
Pan B, Liu L, Hu X, Sun X, Zhu Y, Zhang T, Wei D, Guo Y, Shan J
Journal of gastroenterology and hepatology 2020 Dec;35(12):2131-2139
Journal of gastroenterology and hepatology 2020 Dec;35(12):2131-2139
LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient.
Lee J, Park J, Kim JH, Lee G, Park TE, Yoon KJ, Kim YK, Lim C
PLoS biology 2020 Dec;18(12):e3001002
PLoS biology 2020 Dec;18(12):e3001002
Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.
Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AWM, Akkermans JJLL, Wijdeven RHM, Janssen GMC, van Veelen PA, Neefjes J
Cell reports 2020 Dec 8;33(10):108475
Cell reports 2020 Dec 8;33(10):108475
Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.
Yang T, Sun W, Duan YH, Sun YB, Ren YM, Hou WY, Tian MQ
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
Experimental and therapeutic medicine 2020 Aug;20(2):1775-1781
Peroxisome proliferator activated receptor γ promotes mineralization and differentiation in cementoblasts via inhibiting Wnt/β-catenin signaling pathway.
Hu Y, Wang C, Ha S, Zhu N, Cao Z, Song Y
Journal of cellular biochemistry 2020 Aug;121(8-9):3700-3710
Journal of cellular biochemistry 2020 Aug;121(8-9):3700-3710
Expressional Localization and Functionally Identifying an RNA Editing Enzyme BmADARa of the Silkworm Bombyx mori.
Ye C, Jiang S, Gong M, Min Q, Fan M, Gao J, Meng Y
Insects 2020 Aug 12;11(8)
Insects 2020 Aug 12;11(8)
GADD45G Interacts with E-cadherin to Suppress the Migration and Invasion of Esophageal Squamous Cell Carcinoma.
Li T, Xu L, Teng J, Ma Y, Liu W, Wang Y, Chi X, Shao S, Dong Y, Zhan Q, Liu X
Digestive diseases and sciences 2020 Apr;65(4):1032-1041
Digestive diseases and sciences 2020 Apr;65(4):1032-1041
Ribosome profiling analysis identified a KRAS-interacting microprotein that represses oncogenic signaling in hepatocellular carcinoma cells.
Xu W, Deng B, Lin P, Liu C, Li B, Huang Q, Zhou H, Yang J, Qu L
Science China. Life sciences 2020 Apr;63(4):529-542
Science China. Life sciences 2020 Apr;63(4):529-542
A novel Sprouty4-ERK1/2-Wnt/β-catenin regulatory loop in marrow stromal progenitor cells controls osteogenic and adipogenic differentiation.
Tian L, Xiao H, Li M, Wu X, Xie Y, Zhou J, Zhang X, Wang B
Metabolism: clinical and experimental 2020 Apr;105:154189
Metabolism: clinical and experimental 2020 Apr;105:154189
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Wang Y, Yang Y, Zuo R, Wu J, Zhang C, Li C, Liu M, Zhou Y
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.
Ortega JA, Daley EL, Kour S, Samani M, Tellez L, Smith HS, Hall EA, Esengul YT, Tsai YH, Gendron TF, Donnelly CJ, Siddique T, Savas JN, Pandey UB, Kiskinis E
Neuron 2020 Apr 8;106(1):90-107.e13
Neuron 2020 Apr 8;106(1):90-107.e13
SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia.
Kong Q, Li Y, Liang Q, Xie J, Li X, Fang J
Cancer biology & therapy 2020 Apr 2;21(4):320-331
Cancer biology & therapy 2020 Apr 2;21(4):320-331
Interleukin-17 suppresses grass carp reovirus infection in Ctenopharyngodon idellus kidney cells by activating NF-κB signaling.
Zhang Y, Zhang X, Liang Z, Dai K, Zhu M, Zhang M, Pan J, Xue R, Cao G, Tang J, Song X, Hu X, Gong C
Aquaculture (Amsterdam, Netherlands) 2020 Apr 15;520:734969
Aquaculture (Amsterdam, Netherlands) 2020 Apr 15;520:734969
Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.
Xu X, Wang D, Zheng C, Gao B, Fan J, Cheng P, Liu B, Yang L, Luo Z
Theranostics 2019;9(8):2252-2267
Theranostics 2019;9(8):2252-2267
p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma.
Yang PM, Hong YH, Hsu KC, Liu TP
American journal of cancer research 2019;9(10):2120-2139
American journal of cancer research 2019;9(10):2120-2139
LncRNA SNHG16 promotes epithelial- mesenchymal transition via down-regulation of DKK3 in gastric cancer.
Zhou C, Zhao J, Liu J, Wei S, Xia Y, Xia W, Bi Y, Yan Z, Huang H
Cancer biomarkers : section A of Disease markers 2019;26(4):393-401
Cancer biomarkers : section A of Disease markers 2019;26(4):393-401
Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats.
Li J, Liu Y, Liu B, Li F, Hu J, Wang Q, Li M, Lou S
Neural plasticity 2019;2019:7920540
Neural plasticity 2019;2019:7920540
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z
Oxidative medicine and cellular longevity 2019;2019:6521218
Oxidative medicine and cellular longevity 2019;2019:6521218
Nuclear CD44 Mediated by Importin β Participated in Naïve Genes Transcriptional Regulation in C3A-iCSCs.
Su M, Wang P, Wang X, Zhang M, Wei S, Liu K, Han S, Han X, Deng Y, Shen L
International journal of biological sciences 2019;15(6):1252-1260
International journal of biological sciences 2019;15(6):1252-1260
Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes.
Trajkovic K, Valdez C, Ysselstein D, Krainc D
PloS one 2019;14(2):e0211727
PloS one 2019;14(2):e0211727
Revealing Antidepressant Mechanisms of Baicalin in Hypothalamus Through Systems Approaches in Corticosterone- Induced Depressed Mice.
Zhang K, He M, Wang F, Zhang H, Li Y, Yang J, Wu C
Frontiers in neuroscience 2019;13:834
Frontiers in neuroscience 2019;13:834
Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells.
Palikhe S, Ohashi W, Sakamoto T, Hattori K, Kawakami M, Andoh T, Yamazaki H, Hattori Y
Frontiers in pharmacology 2019;10:59
Frontiers in pharmacology 2019;10:59
The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster.
Mu F, Huang J, Xing T, Jing Y, Cui T, Guo Y, Yan X, Li H, Wang N
Frontiers in genetics 2019;10:525
Frontiers in genetics 2019;10:525
DDX23, an Evolutionary Conserved dsRNA Sensor, Participates in Innate Antiviral Responses by Pairing With TRIF or MAVS.
Ruan J, Cao Y, Ling T, Li P, Wu S, Peng D, Wang Y, Jia X, Chen S, Xu A, Yuan S
Frontiers in immunology 2019;10:2202
Frontiers in immunology 2019;10:2202
Leptin-Induced Angiogenesis of EA.Hy926 Endothelial Cells via the Akt and Wnt Signaling Pathways In Vitro and In Vivo.
Yu F, Fu R, Liu L, Wang X, Wu T, Shen W, Gui Z, Mo X, Fang B, Xia L
Frontiers in pharmacology 2019;10:1275
Frontiers in pharmacology 2019;10:1275
Aerobic Exercise Improves Synaptic-Related Proteins of Diabetic Rats by Inhibiting FOXO1/NF-κB/NLRP3 Inflammatory Signaling Pathway and Ameliorating PI3K/Akt Insulin Signaling Pathway.
Wang Q, Hu J, Liu Y, Li J, Liu B, Li M, Lou S
Journal of molecular neuroscience : MN 2019 Sep;69(1):28-38
Journal of molecular neuroscience : MN 2019 Sep;69(1):28-38
Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial-mesenchymal transition in ovarian carcinoma.
Yang T, Zhou R, Yu S, Yu S, Cui Z, Hu P, Liu J, Qiao Q, Zhang J
Molecular and cellular biochemistry 2019 Sep;459(1-2):157-169
Molecular and cellular biochemistry 2019 Sep;459(1-2):157-169
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Li AL, Shen T, Wang T, Zhou MX, Wang B, Song JT, Zhang PL, Wang XL, Ren DM, Lou HX, Wang XN
Free radical biology & medicine 2019 Sep;141:21-33
Free radical biology & medicine 2019 Sep;141:21-33
A hidden human proteome encoded by 'non-coding' genes.
Lu S, Zhang J, Lian X, Sun L, Meng K, Chen Y, Sun Z, Yin X, Li Y, Zhao J, Wang T, Zhang G, He QY
Nucleic acids research 2019 Sep 5;47(15):8111-8125
Nucleic acids research 2019 Sep 5;47(15):8111-8125
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
MicroRNA-99a is a Potential Target for Regulating Hypothalamic Synaptic Plasticity in the Peri/Postmenopausal Depression Model.
Yang J, Zhang L, Cao LL, Qi J, Li P, Wang XP, Sun XL
Cells 2019 Sep 13;8(9)
Cells 2019 Sep 13;8(9)
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Wu XY, Chen XM, Zhou MX, Hu HX, Zhang JZ, Wang XN, Ren DM, Lou HX, Shen T
Chemico-biological interactions 2019 Sep 1;310:108741
Chemico-biological interactions 2019 Sep 1;310:108741
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury.
Le K, Chibaatar Daliv E, Wu S, Qian F, Ali AI, Yu D, Guo Y
International immunopharmacology 2019 Oct;75:105779
International immunopharmacology 2019 Oct;75:105779
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Tian S, Lei P, Teng C, Sun Y, Song X, Li B, Shan Y
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Molecular nutrition & food research 2019 Oct;63(20):e1900183
AEBP1, a prognostic indicator, promotes colon adenocarcinoma cell growth and metastasis through the NF-κB pathway.
Xing Y, Zhang Z, Chi F, Zhou Y, Ren S, Zhao Z, Zhu Y, Piao D
Molecular carcinogenesis 2019 Oct;58(10):1795-1808
Molecular carcinogenesis 2019 Oct;58(10):1795-1808
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Yang Q, Fan W, Zheng Z, Lin S, Liu C, Wang R, Li W, Zuo Y, Sun Y, Hu S, Chen M, Guo P, Pan J, Tian C, Zhu T, Diao C, Hao J, Yu W, Li L, Li Y, Guo W, Deng W, Wu X
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
Follicle-stimulating hormone promotes renal tubulointerstitial fibrosis in aging women via the AKT/GSK-3β/β-catenin pathway.
Zhang K, Kuang L, Xia F, Chen Y, Zhang W, Zhai H, Wang C, Wang N, Lu Y
Aging cell 2019 Oct;18(5):e12997
Aging cell 2019 Oct;18(5):e12997
Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury.
Zhong Y, Chen J, Chen J, Chen Y, Li L, Xie Y
Journal of neurochemistry 2019 Oct;151(2):166-184
Journal of neurochemistry 2019 Oct;151(2):166-184
P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus.
Cao L, Ji Y, Zeng L, Liu Q, Zhang Z, Guo S, Guo X, Tong Y, Zhao X, Li CM, Chen Y, Guo D
PLoS pathogens 2019 Oct;15(10):e1008079
PLoS pathogens 2019 Oct;15(10):e1008079
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
Arsenic trioxide inhibits angiogenesis in vitro and in vivo by upregulating FoxO3a.
Sun Z, Li M, Bai L, Fu J, Lu J, Wu M, Zhou C, Zhang Y, Wu Y
Toxicology letters 2019 Oct 15;315:1-8
Toxicology letters 2019 Oct 15;315:1-8
TMEM18 inhibits osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells by inactivating β-catenin.
Zhang Y, Wang H, Yin T, Liu Y, Zhou W, Fan X, Wu L, Song C, Shao J, Yang T
Experimental cell research 2019 Oct 1;383(1):111491
Experimental cell research 2019 Oct 1;383(1):111491
Type I collagen or gelatin stimulates mouse peritoneal macrophages to aggregate and produce pro-inflammatory molecules through upregulated ROS levels.
Zhang X, Chen YR, Zhao YL, Liu WW, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ogura T, Onodera S, Ikejima T
International immunopharmacology 2019 Nov;76:105845
International immunopharmacology 2019 Nov;76:105845
The protective effects of L-carnitine on myocardial ischaemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-κB pathway and the activation of Nrf2 pathway.
Li M, Xu S, Geng Y, Sun L, Wang R, Yan Y, Wang H, Li Y, Yi Q, Zhang Y, Hao J, Deng C, Li W, Xue L
Clinical and experimental pharmacology & physiology 2019 Nov;46(11):1001-1012
Clinical and experimental pharmacology & physiology 2019 Nov;46(11):1001-1012
Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism.
Yap JLY, Tai YK, Fröhlich J, Fong CHH, Yin JN, Foo ZL, Ramanan S, Beyer C, Toh SJ, Casarosa M, Bharathy N, Kala MP, Egli M, Taneja R, Lee CN, Franco-Obregón A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12853-12872
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):12853-12872
Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion.
Li Y, Feng D, Wang Z, Zhao Y, Sun R, Tian D, Liu D, Zhang F, Ning S, Yao J, Tian X
Cell death and differentiation 2019 Nov;26(11):2284-2299
Cell death and differentiation 2019 Nov;26(11):2284-2299
DYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild-type NSCLC cells to AZD9291.
Li YL, Ding K, Hu X, Wu LW, Zhou DM, Rao MJ, Lin NM, Zhang C
Journal of cellular and molecular medicine 2019 Nov;23(11):7427-7437
Journal of cellular and molecular medicine 2019 Nov;23(11):7427-7437
Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS.
Wang Y, Yuan S, Jia X, Ge Y, Ling T, Nie M, Lan X, Chen S, Xu A
Nature cell biology 2019 Nov;21(11):1346-1356
Nature cell biology 2019 Nov;21(11):1346-1356
Downregulation of transgelin 2 promotes breast cancer metastasis by activating the reactive oxygen species/nuclear factor‑κB signaling pathway.
Yang L, Hong Q, Xu SG, Kuang XY, Di GH, Liu GY, Wu J, Shao ZM, Yu SJ
Molecular medicine reports 2019 Nov;20(5):4045-4258
Molecular medicine reports 2019 Nov;20(5):4045-4258
Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa B signaling pathway.
Liu L, Qu Y, Liu Y, Zhao H, Ma HC, Noor AF, Ji CJ, Nie L, Si M, Cheng L
Neural regeneration research 2019 Nov;14(11):1994-2002
Neural regeneration research 2019 Nov;14(11):1994-2002
ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma.
Liang B, Chen R, Song S, Wang H, Sun G, Yang H, Jing W, Zhou X, Fu Z, Huang G, Zhao J
Cell death & disease 2019 Nov 4;10(11):830
Cell death & disease 2019 Nov 4;10(11):830
A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells.
Wan W, Wang L, Chen X, Zhu S, Shang W, Xiao G, Zhang LK
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
Molecules (Basel, Switzerland) 2019 Nov 20;24(23)
PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy.
Li Q, Li ZM, Sun SY, Wang LP, Wang PX, Guo Z, Yang HW, Ye JT, Lu J, Liu PQ
Acta pharmacologica Sinica 2019 May;40(5):589-598
Acta pharmacologica Sinica 2019 May;40(5):589-598
Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy.
Feng W, Wang J, Yan X, Zhai C, Shi W, Wang Q, Zhang Q, Li M
Naunyn-Schmiedeberg's archives of pharmacology 2019 May;392(5):605-613
Naunyn-Schmiedeberg's archives of pharmacology 2019 May;392(5):605-613
Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels.
Li N, Wang T, Li Z, Ye X, Deng B, Zhuo S, Yao P, Yang M, Mei H, Chen X, Zhu T, Chen S, Wang H, Wang J, Le Y
Cancer biology & medicine 2019 May;16(2):220-233
Cancer biology & medicine 2019 May;16(2):220-233
A cellular model for Wilson's disease using patient-derived induced pluripotent stem cells revealed aberrant β-catenin pathway during osteogenesis.
Liu J, Cui Y, Shi L, Luan J, Zhou X, Han J
Biochemical and biophysical research communications 2019 May 28;513(2):386-391
Biochemical and biophysical research communications 2019 May 28;513(2):386-391
Ginsenoside Rk3 ameliorates high-fat-diet/streptozocin induced type 2 diabetes mellitus in mice via the AMPK/Akt signaling pathway.
Liu Y, Deng J, Fan D
Food & function 2019 May 22;10(5):2538-2551
Food & function 2019 May 22;10(5):2538-2551
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Sodium ferulate protects against influenza virus infection by activation of the TLR7/9-MyD88-IRF7 signaling pathway and inhibition of the NF-κB signaling pathway.
Zhu Y, Shao Y, Qu X, Guo J, Yang J, Zhou Z, Wang S
Biochemical and biophysical research communications 2019 May 14;512(4):793-798
Biochemical and biophysical research communications 2019 May 14;512(4):793-798
Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.
Zhang Y, Chen Y, Zheng J, Wang J, Duan S, Zhang W, Yan X, Zhu X
Journal of molecular cell biology 2019 May 1;11(5):383-394
Journal of molecular cell biology 2019 May 1;11(5):383-394
Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation.
Han M, Zhao M, Cheng C, Huang Y, Han S, Li W, Tu X, Luo X, Yu X, Liu Y, Chen Q, Ren X, Wang QK, Ke T
Human mutation 2019 Mar;40(3):310-325
Human mutation 2019 Mar;40(3):310-325
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia.
Liu Y, Xue X, Zhang H, Che X, Luo J, Wang P, Xu J, Xing Z, Yuan L, Liu Y, Fu X, Su D, Sun S, Zhang H, Wu C, Yang J
Autophagy 2019 Mar;15(3):493-509
Autophagy 2019 Mar;15(3):493-509
Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence.
Xu X, Liu Q, Zhang C, Ren S, Xu L, Zhao Z, Dou H, Li P, Zhang X, Gong Y, Shao C
Cell death & disease 2019 Mar 25;10(4):282
Cell death & disease 2019 Mar 25;10(4):282
Discovery of human TyrRS inhibitors by structure-based virtual screening, structural optimization, and bioassays.
Huang S, Wang X, Lin G, Cheng J, Chen X, Sun W, Xiang R, Yu Y, Li L, Yang S
RSC advances 2019 Mar 15;9(16):9323-9330
RSC advances 2019 Mar 15;9(16):9323-9330
In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways.
Zhang C, Li C, Jia X, Wang K, Tu Y, Wang R, Liu K, Lu T, He C
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Molecules (Basel, Switzerland) 2019 Mar 1;24(5)
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Park JS, Lee YS, Lee DH, Bae SH
Free radical biology & medicine 2019 Jun;137:143-157
Free radical biology & medicine 2019 Jun;137:143-157
Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis.
Yan Y, Qin D, Hu B, Zhang C, Liu S, Wu D, Huang W, Huang X, Wang L, Chen X, Zhang L
Molecular therapy. Nucleic acids 2019 Jun 7;16:494-504
Molecular therapy. Nucleic acids 2019 Jun 7;16:494-504
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells.
Chen MK, Peng CC, Maner RS, Zulkefli ND, Huang SM, Hsieh CL
Life sciences 2019 Jun 1;226:1-11
Life sciences 2019 Jun 1;226:1-11
IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
Zhang W, Lu Y, Li X, Zhang J, Lin W, Zhang W, Zheng L, Li X
Journal of experimental & clinical cancer research : CR 2019 Jul 9;38(1):296
Journal of experimental & clinical cancer research : CR 2019 Jul 9;38(1):296
DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.
Li D, Fu S, Wu Z, Yang W, Ru Y, Shu H, Liu X, Zheng H
Journal of cell science 2019 Jul 24;133(5)
Journal of cell science 2019 Jul 24;133(5)
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells.
Zhang Q, Liu RX, Chan KW, Hu J, Zhang J, Wei L, Tan H, Yang X, Liu H
Journal of experimental & clinical cancer research : CR 2019 Jul 19;38(1):320
Journal of experimental & clinical cancer research : CR 2019 Jul 19;38(1):320
IL-1β receptor antagonist (IL-1Ra) combined with autophagy inducer (TAT-Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes.
Wang F, Liu J, Chen X, Zheng X, Qu N, Zhang B, Xia C
Arthritis research & therapy 2019 Jul 10;21(1):171
Arthritis research & therapy 2019 Jul 10;21(1):171
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Shan H, Li T, Zhang L, Yang R, Li Y, Zhang M, Dong Y, Zhou Y, Xu C, Yang B, Liang H, Gao X, Shan H
EBioMedicine 2019 Jan;39:59-68
EBioMedicine 2019 Jan;39:59-68
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, Luo O, Wang S, Wei J, Ding Y, Yu D
EBioMedicine 2019 Jan;39:239-254
EBioMedicine 2019 Jan;39:239-254
Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells.
Qi S, Zhang P, Ma M, Yao M, Wu J, Mäkilä E, Salonen J, Ruskoaho H, Xu Y, Santos HA, Zhang H
Small (Weinheim an der Bergstrasse, Germany) 2019 Jan;15(1):e1804332
Small (Weinheim an der Bergstrasse, Germany) 2019 Jan;15(1):e1804332
Attenuation of Atherosclerosis by Protocatechuic Acid via Inhibition of M1 and Promotion of M2 Macrophage Polarization.
Liu Y, Wang X, Pang J, Zhang H, Luo J, Qian X, Chen Q, Ling W
Journal of agricultural and food chemistry 2019 Jan 23;67(3):807-818
Journal of agricultural and food chemistry 2019 Jan 23;67(3):807-818
The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest.
Trendel J, Schwarzl T, Horos R, Prakash A, Bateman A, Hentze MW, Krijgsveld J
Cell 2019 Jan 10;176(1-2):391-403.e19
Cell 2019 Jan 10;176(1-2):391-403.e19
Diallyl sulfide treatment protects against acetaminophen-/carbon tetrachloride-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.
Li M, Wang S, Li X, Kou R, Wang Q, Wang X, Zhao N, Zeng T, Xie K
Toxicology research 2019 Jan 1;8(1):67-76
Toxicology research 2019 Jan 1;8(1):67-76
USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.
Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutierrez-Diaz BT, Wang KK, Johnson MR, Volk AG, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, Abshiru NA, Hijiya N, Peirs S, Vandamme N, Berx G, Goosens S, Marshall SA, Rendleman EJ, Takahashi YH, Wang L, Rawat R, Bartom ET, Collings CK, Van Vlierberghe P, Strikoudis A, Kelly S, Ueberheide B, Mantis C, Kandela I, Bourquin JP, Bornhauser B, Serafin V, Bresolin S, Paganin M, Accordi B, Basso G, Kelleher NL, Weinstock J, Kumar S, Crispino JD, Shilatifard A, Ntziachristos P
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Jan 1;25(1):222-239
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Jan 1;25(1):222-239
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells.
Xu L, Liu JT, Li K, Wang SY, Xu S
Life sciences 2019 Jan 1;216:140-146
Life sciences 2019 Jan 1;216:140-146
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Molecular nutrition & food research 2019 Feb;63(4):e1800795
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Li Y, Chen Y, Qiu C, Ma X, Lei K, Cai G, Liang X, Liu J
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model.
Liu Q, Xie W, Wang Y, Chen S, Han J, Wang L, Gui P, Wu Q
Laboratory investigation; a journal of technical methods and pathology 2019 Dec;99(12):1810-1821
Laboratory investigation; a journal of technical methods and pathology 2019 Dec;99(12):1810-1821
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y
Free radical biology & medicine 2019 Dec;145:146-160
Free radical biology & medicine 2019 Dec;145:146-160
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Wang J, Li L, Wang J, Song L, Tan N, Wang Z
Cells 2019 Dec 7;8(12)
Cells 2019 Dec 7;8(12)
Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.
Binning JM, Chesarino NM, Emerman M, Gross JD
Cell host & microbe 2019 Dec 11;26(6):739-747.e4
Cell host & microbe 2019 Dec 11;26(6):739-747.e4
Anacardic acid inhibits RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced bone loss in vivo.
Zhao K, Jia Y, Peng J, Pang C, Zhang T, Han W, Jiang J, Lu X, Zhu J, Qian Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9100-9115
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9100-9115
The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors.
Cao P, Luo WW, Li C, Tong Z, Zheng ZQ, Zhou L, Xiong Y, Li S
PLoS pathogens 2019 Aug;15(8):e1007983
PLoS pathogens 2019 Aug;15(8):e1007983
Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Yang HM, Lian S
Biomolecules 2019 Aug 30;9(9)
Biomolecules 2019 Aug 30;9(9)
Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia.
Yang X, Wang G, Cao T, Zhang L, Ma Y, Jiang S, Teng X, Sun X
The Journal of biological chemistry 2019 Aug 30;294(35):12921-12932
The Journal of biological chemistry 2019 Aug 30;294(35):12921-12932
Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling.
Diao H, Cheng N, Zhao Y, Xu H, Dong H, Thamm DH, Zhang D, Lin D
BMC veterinary research 2019 Aug 2;15(1):276
BMC veterinary research 2019 Aug 2;15(1):276
High-mobility group box 1 protein modulated proliferation and radioresistance in esophageal squamous cell carcinoma.
Di X, He G, Chen H, Zhu C, Qin Q, Yan J, Zhang X, Sun X
Journal of gastroenterology and hepatology 2019 Apr;34(4):728-735
Journal of gastroenterology and hepatology 2019 Apr;34(4):728-735
Knockdown of Golgi phosphoprotein 73 blocks the trafficking of matrix metalloproteinase-2 in hepatocellular carcinoma cells and inhibits cell invasion.
Liu Y, Zhang X, Zhou S, Shi J, Xu Y, He J, Lin F, Wei A, Zhou L, Chen Z
Journal of cellular and molecular medicine 2019 Apr;23(4):2399-2409
Journal of cellular and molecular medicine 2019 Apr;23(4):2399-2409
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Zhou X, Li W, Wang S, Zhang P, Wang Q, Xiao J, Zhang C, Zheng X, Xu X, Xue S, Hui L, Ji H, Wei B, Wang H
Cell reports 2019 Apr 23;27(4):1176-1189.e5
Cell reports 2019 Apr 23;27(4):1176-1189.e5
Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner.
Qin Z, Xiang C, Zhong F, Liu Y, Dong Q, Li K, Shi W, Ding C, Qin L, He F
Journal of experimental & clinical cancer research : CR 2019 Apr 11;38(1):154
Journal of experimental & clinical cancer research : CR 2019 Apr 11;38(1):154
Glycyrrhizin Protects Mice Against Experimental Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1 (HMGB1) Expression and Neuronal HMGB1 Release.
Sun Y, Chen H, Dai J, Wan Z, Xiong P, Xu Y, Han Z, Chai W, Gong F, Zheng F
Frontiers in immunology 2018;9:1518
Frontiers in immunology 2018;9:1518
An Immunosuppressive Tick Salivary Gland Protein DsCystatin Interferes With Toll-Like Receptor Signaling by Downregulating TRAF6.
Sun T, Wang F, Pan W, Wu Q, Wang J, Dai J
Frontiers in immunology 2018;9:1245
Frontiers in immunology 2018;9:1245
Overexpression of β-Catenin Decreases the Radiosensitivity of Human Nasopharyngeal Carcinoma CNE-2 Cells.
He H, Lin K, Su Y, Lin S, Zou C, Pan J, Zhou Y, Chen C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1929-1944
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1929-1944
Constitutive Activation of β-Catenin in Differentiated Osteoclasts Induces Bone Loss in Mice.
Sui X, Deng S, Liu M, Fan L, Wang Y, Xu H, Sun Y, Kishen A, Zhang Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):2091-2102
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):2091-2102
Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway.
Liu X, Zhu Q, Zhang M, Yin T, Xu R, Xiao W, Wu J, Deng B, Gao X, Gong W, Lu G, Ding Y
Oxidative medicine and cellular longevity 2018;2018:7161592
Oxidative medicine and cellular longevity 2018;2018:7161592
Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells.
Cui S, Men L, Li Y, Zhong Y, Yu S, Li F, Du J
Mediators of inflammation 2018;2018:1625414
Mediators of inflammation 2018;2018:1625414
Prostaglandin F(2α) Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.
Wang Y, Yan S, Xiao B, Zuo S, Zhang Q, Chen G, Yu Y, Chen D, Liu Q, Liu Y, Shen Y, Yu Y
Diabetes 2018 Sep;67(9):1748-1760
Diabetes 2018 Sep;67(9):1748-1760
Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets.
Nguyen A, Guedán A, Mousnier A, Swieboda D, Zhang Q, Horkai D, Le Novere N, Solari R, Wakelam MJO
Journal of lipid research 2018 Sep;59(9):1671-1684
Journal of lipid research 2018 Sep;59(9):1671-1684
IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3.
Jiang LQ, Xia T, Hu YH, Sun MS, Yan S, Lei CQ, Shu HB, Guo JH, Liu Y
Cellular & molecular immunology 2018 Sep;15(9):858-867
Cellular & molecular immunology 2018 Sep;15(9):858-867
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, Zhang XN, Guo Y, Lei CQ, Yang Q, Luo WW, Li S, Shu HB
Immunity 2018 Sep 18;49(3):438-448.e5
Immunity 2018 Sep 18;49(3):438-448.e5
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor κB-Matrix Metalloproteinase Signaling.
Wang Y, Wang Y, Liu Z, Dong W, Yang B, Xia X, Song E, Song Y
Chemical research in toxicology 2018 Sep 17;31(9):954-963
Chemical research in toxicology 2018 Sep 17;31(9):954-963
Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus.
Wu CC, Jiang X, Wang XZ, Liu XJ, Li XJ, Yang B, Ye HQ, Harwardt T, Jiang M, Xia HM, Wang W, Britt WJ, Paulus C, Nevels M, Luo MH
Journal of virology 2018 Sep 1;92(17)
Journal of virology 2018 Sep 1;92(17)
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.
Zhai C, Shi W, Feng W, Zhu Y, Wang J, Li S, Yan X, Wang Q, Zhang Q, Chai L, Li C, Liu P, Li M
Life sciences 2018 Sep 1;208:87-95
Life sciences 2018 Sep 1;208:87-95
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Astrocyte elevated gene-1 participates in the production of pro-inflammatory cytokines in dental pulp cells via NF-κB signalling pathway.
Wu H, He M, Yang R, Zuo Y, Bian Z
International endodontic journal 2018 Oct;51(10):1130-1138
International endodontic journal 2018 Oct;51(10):1130-1138
Comparison of the Effects and Inhibitory Pathways of the Constituents from Gynostemma pentaphyllum against LPS-Induced Inflammatory Response.
Shen CY, Jiang JG, Shi MM, Yang HL, Wei H, Zhu W
Journal of agricultural and food chemistry 2018 Oct 31;66(43):11337-11346
Journal of agricultural and food chemistry 2018 Oct 31;66(43):11337-11346
Salvianolic Acid B-Alleviated Angiotensin II Induces Cardiac Fibrosis by Suppressing NF-κB Pathway In Vitro.
Wang C, Luo H, Xu Y, Tao L, Chang C, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2018 Oct 26;24:7654-7664
Medical science monitor : international medical journal of experimental and clinical research 2018 Oct 26;24:7654-7664
ERα is a negative regulator of PD-L1 gene transcription in breast cancer.
Liu L, Shen Y, Zhu X, Lv R, Li S, Zhang Z, Shi YG, Tan L
Biochemical and biophysical research communications 2018 Oct 20;505(1):157-161
Biochemical and biophysical research communications 2018 Oct 20;505(1):157-161
Dynamic changes of proteasome and protective effect of bortezomib, a proteasome inhibitor, in mice with acute pancreatitis.
Zhu Q, Lin X, Liu X, Hou T, Zhang M, Wang N, Chen W, Lu G, Gong W, Ding Y, Xiao W
Biochemical and biophysical research communications 2018 Oct 20;505(1):126-133
Biochemical and biophysical research communications 2018 Oct 20;505(1):126-133
TRPV2-induced Ca(2+)-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.
Bai H, Zhu H, Yan Q, Shen X, Lu X, Wang J, Li J, Chen L
Cell communication and signaling : CCS 2018 Oct 16;16(1):68
Cell communication and signaling : CCS 2018 Oct 16;16(1):68
PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy.
Wang L, Li Z, Tan Y, Li Q, Yang H, Wang P, Lu J, Liu P
Molecular and cellular endocrinology 2018 Oct 15;474:137-150
Molecular and cellular endocrinology 2018 Oct 15;474:137-150
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.
Yoney A, Etoc F, Ruzo A, Carroll T, Metzger JJ, Martyn I, Li S, Kirst C, Siggia ED, Brivanlou AH
eLife 2018 Oct 12;7
eLife 2018 Oct 12;7
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
Li YR, Li GH, Zhou MX, Xiang L, Ren DM, Lou HX, Wang XN, Shen T
Bioorganic & medicinal chemistry 2018 Oct 1;26(18):5140-5150
Bioorganic & medicinal chemistry 2018 Oct 1;26(18):5140-5150
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation.
Shi W, Zhai C, Feng W, Wang J, Zhu Y, Li S, Wang Q, Zhang Q, Yan X, Chai L, Liu P, Chen Y, Li M
Life sciences 2018 Oct 1;210:140-149
Life sciences 2018 Oct 1;210:140-149
Redox-active trace metal-induced release of high mobility group box 1(HMGB1) and inflammatory cytokines in fibroblast-like synovial cells is Toll-like receptor 4 (TLR4) dependent.
Alsousi AA, Igwe OJ
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3847-3858
Biochimica et biophysica acta. Molecular basis of disease 2018 Nov;1864(11):3847-3858
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, Li F, Chen A, Huang S
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Zhang LM, Zhang J, Zhang Y, Wang L, Fei C, Yi ZW, Dong L
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
Tetrachlorobenzoquinone-Induced Nrf2 Confers Neuron-like PC12 Cells Resistance to Endoplasmic Reticulum Stress via Regulating Glutathione Synthesis and Protein Thiol Homeostasis.
Liu Z, Dong W, Yang B, Peng L, Xia X, Pu L, Zhang N, Song E, Song Y
Chemical research in toxicology 2018 Nov 19;31(11):1230-1239
Chemical research in toxicology 2018 Nov 19;31(11):1230-1239
Polybrominated Diphenyl Ethers Quinone Induced Parthanatos-like Cell Death through a Reactive Oxygen Species-Associated Poly(ADP-ribose) Polymerase 1 Signaling.
Dong W, Yang B, Wang Y, Yuan J, Fan Y, Song E, Song Y
Chemical research in toxicology 2018 Nov 19;31(11):1164-1171
Chemical research in toxicology 2018 Nov 19;31(11):1164-1171
Follicle-stimulating hormone enhances hepatic gluconeogenesis by GRK2-mediated AMPK hyperphosphorylation at Ser485 in mice.
Qi X, Guo Y, Song Y, Yu C, Zhao L, Fang L, Kong D, Zhao J, Gao L
Diabetologia 2018 May;61(5):1180-1192
Diabetologia 2018 May;61(5):1180-1192
Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways.
Li CH, Xu LL, Jian LL, Yu RH, Zhao JX, Sun L, Du GH, Liu XY
International immunopharmacology 2018 May;58:136-144
International immunopharmacology 2018 May;58:136-144
Folic acid supplementation repressed hypoxia-induced inflammatory response via ROS and JAK2/STAT3 pathway in human promyelomonocytic cells.
Ma J, Zhen X, Huang X, Jiang X
Nutrition research (New York, N.Y.) 2018 May;53:40-50
Nutrition research (New York, N.Y.) 2018 May;53:40-50
Dysregulation of tristetraprolin and human antigen R promotes gastric cancer progressions partly by upregulation of the high-mobility group box 1.
Wang H, Chen Y, Guo J, Shan T, Deng K, Chen J, Cai L, Zhou H, Zhao Q, Jin S, Xia J
Scientific reports 2018 May 4;8(1):7080
Scientific reports 2018 May 4;8(1):7080
OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos.
Wang R, Li C, Qiao P, Xue Y, Zheng X, Chen H, Zeng X, Liu W, Boldogh I, Ba X
Cell death & disease 2018 May 24;9(6):628
Cell death & disease 2018 May 24;9(6):628
Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells.
Hong F, Wan L, Liu J, Huang K, Xiao Z, Zhang Y, Shi C
FEBS open bio 2018 Mar;8(3):406-415
FEBS open bio 2018 Mar;8(3):406-415
Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.
Tian S, Li B, Lei P, Yang X, Zhang X, Bao Y, Shan Y
Molecular nutrition & food research 2018 Mar;62(6):e1700737
Molecular nutrition & food research 2018 Mar;62(6):e1700737
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Exosomes from C2C12 myoblasts enhance osteogenic differentiation of MC3T3-E1 pre-osteoblasts by delivering miR-27a-3p.
Xu Q, Cui Y, Luan J, Zhou X, Li H, Han J
Biochemical and biophysical research communications 2018 Mar 25;498(1):32-37
Biochemical and biophysical research communications 2018 Mar 25;498(1):32-37
Calpain and JNK pathways participate in isoflurane - induced nucleus translocation of apoptosis-inducing factor in the brain of neonatal rats.
Han X, Liu C, Zhang K, Guo M, Shen Z, Liu Y, Zuo Z, Cao M, Li Y
Toxicology letters 2018 Mar 15;285:60-73
Toxicology letters 2018 Mar 15;285:60-73
PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein.
Zhang J, Yang C, Zhou F, Chen X
Oncology reports 2018 Jun;39(6):2951-2959
Oncology reports 2018 Jun;39(6):2951-2959
Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling.
Yang Y, Qi Q, Wang Y, Shi Y, Yang W, Cen Y, Zhu E, Li X, Chen D, Wang B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun;32(6):3096-3107
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun;32(6):3096-3107
Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor.
Kai W, Yating S, Lin M, Kaiyong Y, Baojin H, Wu Y, Fangzhou Y, Yan C
Biochemical pharmacology 2018 Jun;152:153-164
Biochemical pharmacology 2018 Jun;152:153-164
Excessive endoplasmic reticulum stress and decreased neuroplasticity-associated proteins in prefrontal cortex of obese rats and the regulatory effects of aerobic exercise.
Li F, Liu BB, Cai M, Li JJ, Lou SJ
Brain research bulletin 2018 Jun;140:52-59
Brain research bulletin 2018 Jun;140:52-59
Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway.
Tao L, Li D, Liu H, Jiang F, Xu Y, Cao Y, Gao R, Chen G
Brain research bulletin 2018 Jun;140:154-161
Brain research bulletin 2018 Jun;140:154-161
Fam83h mutation inhibits the mineralization in ameloblasts by activating Wnt/β-catenin signaling pathway.
Yang M, Huang W, Yang F, Zhang T, Wang C, Song Y
Biochemical and biophysical research communications 2018 Jun 18;501(1):206-211
Biochemical and biophysical research communications 2018 Jun 18;501(1):206-211
Long noncoding RNA lncARSR promotes hepatic cholesterol biosynthesis via modulating Akt/SREBP-2/HMGCR pathway.
Huang J, Chen S, Cai D, Bian D, Wang F
Life sciences 2018 Jun 15;203:48-53
Life sciences 2018 Jun 15;203:48-53
An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness.
Galarza Torre A, Shaw JE, Wood A, Gilbert HTJ, Dobre O, Genever P, Brennan K, Richardson SM, Swift J
Scientific reports 2018 Jun 12;8(1):8981
Scientific reports 2018 Jun 12;8(1):8981
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW
The Journal of clinical investigation 2018 Jun 1;128(6):2281-2296
The Journal of clinical investigation 2018 Jun 1;128(6):2281-2296
Sub-lethal ultraviolet B irradiation and Poly I:C treatment synergistically induced apoptosis of HaCaT cells through NF-κB pathway.
Otkur W, Liu W, Wang J, Jia X, Huang D, Wang F, Hayashi T, Tashiro SI, Onodera S, Ikejima T
Molecular immunology 2018 Jul;99:19-29
Molecular immunology 2018 Jul;99:19-29
Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinoma.
Zhang S, Xie C, Li H, Zhang K, Li J, Wang X, Yin Z
Laboratory investigation; a journal of technical methods and pathology 2018 Jul;98(7):883-894
Laboratory investigation; a journal of technical methods and pathology 2018 Jul;98(7):883-894
Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation.
Zhang Y, Li A, Shi J, Fang Y, Gu C, Cai J, Lin C, Zhao L, Liu S
Cell death & disease 2018 Jul 3;9(7):749
Cell death & disease 2018 Jul 3;9(7):749
Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats.
Shi X, Zhao Y, Ding C, Wang Z, Ji A, Li Z, Feng D, Li Y, Gao D, Zhou J, Tian X, Yao J
Toxicology and applied pharmacology 2018 Jul 1;350:21-31
Toxicology and applied pharmacology 2018 Jul 1;350:21-31
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Shi A, Shi H, Wang Y, Liu X, Cheng Y, Li H, Zhao H, Wang S, Dong L
International immunopharmacology 2018 Jan;54:125-130
International immunopharmacology 2018 Jan;54:125-130
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
Activation of peroxisome proliferation-activated receptor-γ inhibits transforming growth factor-β1-induced airway smooth muscle cell proliferation by suppressing Smad-miR-21 signaling.
Liu L, Pan Y, Zhai C, Zhu Y, Ke R, Shi W, Wang J, Yan X, Su X, Song Y, Gao L, Li M
Journal of cellular physiology 2018 Jan;234(1):669-681
Journal of cellular physiology 2018 Jan;234(1):669-681
PTEN-L promotes type I interferon responses and antiviral immunity.
Cao Y, Wang H, Yang L, Zhang Z, Li C, Yuan X, Bu L, Chen L, Chen Y, Li CM, Guo D
Cellular & molecular immunology 2018 Jan;15(1):48-57
Cellular & molecular immunology 2018 Jan;15(1):48-57
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Luo W, Zhang J, Liang L, Wang G, Li Q, Zhu P, Zhou Y, Li J, Zhao Y, Sun N, Huang S, Zhou C, Chang Y, Cui P, Chen P, Jiang Y, Deng G, Bu Z, Li C, Jiang L, Chen H
PLoS pathogens 2018 Jan;14(1):e1006851
PLoS pathogens 2018 Jan;14(1):e1006851
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.
Hou Y, Wang Y, He Q, Li L, Xie H, Zhao Y, Zhao J
Behavioural brain research 2018 Jan 15;336:32-39
Behavioural brain research 2018 Jan 15;336:32-39
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
Liu M, Xu H, Zhang L, Zhang C, Yang L, Ma E, Liu L, Li Y
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
IRF1 up-regulates isg15 gene expression in dsRNA stimulation or CSFV infection by targeting nucleotides -487 to -325 in the 5' flanking region.
Li XQ, Li XN, Liang JJ, Cai XB, Tao Q, Li YX, Qin Q, Xu SP, Luo TR
Molecular immunology 2018 Feb;94:153-165
Molecular immunology 2018 Feb;94:153-165
Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway.
Shen Z, Ma Y, Ji Z, Hao Y, Yan X, Zhong Y, Tang X, Ren W
Lipids in health and disease 2018 Feb 9;17(1):26
Lipids in health and disease 2018 Feb 9;17(1):26
LINC01016 promotes the malignant phenotype of endometrial cancer cells by regulating the miR-302a-3p/miR-3130-3p/NFYA/SATB1 axis.
Pan X, Li D, Huo J, Kong F, Yang H, Ma X
Cell death & disease 2018 Feb 21;9(3):303
Cell death & disease 2018 Feb 21;9(3):303
The interactome and spatial redistribution feature of Ca(2+) receptor protein calmodulin reveals a novel role in invadopodia-mediated invasion.
Li T, Yi L, Hai L, Ma H, Tao Z, Zhang C, Abeysekera IR, Zhao K, Yang Y, Wang W, Liu B, Yu S, Tong L, Liu P, Zhu M, Ren B, Lin Y, Zhang K, Cheng C, Huang Y, Yang X
Cell death & disease 2018 Feb 20;9(3):292
Cell death & disease 2018 Feb 20;9(3):292
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.
Li Y, Zhang Z, Chen J, Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G, Wong J, Xu GL, Wang Z, Wang H, Gao S, Zhu B
Nature 2018 Dec;564(7734):136-140
Nature 2018 Dec;564(7734):136-140
Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway.
Fang X, Liu Y, Lu J, Hong H, Yuan J, Zhang Y, Wang P, Liu P, Ye J
Naunyn-Schmiedeberg's archives of pharmacology 2018 Dec;391(12):1373-1385
Naunyn-Schmiedeberg's archives of pharmacology 2018 Dec;391(12):1373-1385
Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling.
Wang J, Qi H, Zhang X, Si W, Xu F, Hou T, Zhou H, Wang A, Li G, Liu Y, Fang Y, Piao HL, Liang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:724-733
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:724-733
PNMA1, regulated by miR-33a-5p, promotes proliferation and EMT in hepatocellular carcinoma by activating the Wnt/β-catenin pathway.
Liu P, Chen B, Gu Y, Liu Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:492-499
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:492-499
The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response.
Lellahi SM, Rosenlund IA, Hedberg A, Kiær LT, Mikkola I, Knutsen E, Perander M
The Journal of biological chemistry 2018 Dec 7;293(49):18965-18976
The Journal of biological chemistry 2018 Dec 7;293(49):18965-18976
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Hu M, Liu L, Yao W
Gene 2018 Dec 15;678:261-269
Gene 2018 Dec 15;678:261-269
Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells.
Tian YS, Chen KC, Zulkefli ND, Maner RS, Hsieh CL
Molecules (Basel, Switzerland) 2018 Dec 14;23(12)
Molecules (Basel, Switzerland) 2018 Dec 14;23(12)
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.
Chen X, Wu L, Li D, Xu Y, Zhang L, Niu K, Kong R, Gu J, Xu Z, Chen Z, Sun J
Cancer medicine 2018 Aug;7(8):3834-3847
Cancer medicine 2018 Aug;7(8):3834-3847
The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation.
Yan X, Lu J, Zou X, Zhang S, Cui Y, Zhou L, Liu F, Shan A, Lu J, Zheng M, Feng B, Zhang Y
The FEBS journal 2018 Aug;285(16):3041-3055
The FEBS journal 2018 Aug;285(16):3041-3055
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
Ke M, Dong J, Wang Y, Zhang J, Zhang M, Wu Z, Lv Y, Wu R
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway.
Li L, Huang W, Wang S, Sun K, Zhang W, Ding Y, Zhang L, Tumen B, Ji L, Liu C
Molecules (Basel, Switzerland) 2018 Aug 14;23(8)
Molecules (Basel, Switzerland) 2018 Aug 14;23(8)
Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration.
Harada A, Maehara K, Ono Y, Taguchi H, Yoshioka K, Kitajima Y, Xie Y, Sato Y, Iwasaki T, Nogami J, Okada S, Komatsu T, Semba Y, Takemoto T, Kimura H, Kurumizaka H, Ohkawa Y
Nature communications 2018 Apr 11;9(1):1400
Nature communications 2018 Apr 11;9(1):1400
TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3.
Sang Y, Li Y, Song L, Alvarez AA, Zhang W, Lv D, Tang J, Liu F, Chang Z, Hatakeyama S, Hu B, Cheng SY, Feng H
Cancer research 2018 Apr 1;78(7):1792-1804
Cancer research 2018 Apr 1;78(7):1792-1804
Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ.
Wang J, Yu Z, Wang C, Tian X, Huo X, Wang Y, Sun C, Feng L, Ma J, Zhang B, Yang Q, Ma X, Xu Y
American journal of cancer research 2017;7(6):1270-1284
American journal of cancer research 2017;7(6):1270-1284
Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.
Wu X, Zhu H, Yan J, Khan M, Yu X
BioMed research international 2017;2017:4734127
BioMed research international 2017;2017:4734127
Necrostatin-1 attenuates early brain injury after subarachnoid hemorrhage in rats by inhibiting necroptosis.
Chen F, Su X, Lin Z, Lin Y, Yu L, Cai J, Kang D, Hu L
Neuropsychiatric disease and treatment 2017;13:1771-1782
Neuropsychiatric disease and treatment 2017;13:1771-1782
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, Xu Y
OncoTargets and therapy 2017;10:5471-5482
OncoTargets and therapy 2017;10:5471-5482
CDKL1 promotes tumor proliferation and invasion in colorectal cancer.
Qin C, Ren L, Ji M, Lv S, Wei Y, Zhu D, Lin Q, Xu P, Chang W, Xu J
OncoTargets and therapy 2017;10:1613-1624
OncoTargets and therapy 2017;10:1613-1624
Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.
Song Z, Shah SZA, Yang W, Dong H, Yang L, Zhou X, Zhao D
Frontiers in molecular neuroscience 2017;10:128
Frontiers in molecular neuroscience 2017;10:128
MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells.
Xie X, Li S, Zhu Y, Liu L, Pan Y, Wang J, Shi W, Song Y, Yang L, Gao L, Zang W, Li M
Cell and tissue research 2017 Sep;369(3):527-539
Cell and tissue research 2017 Sep;369(3):527-539
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling.
Song Z, Yang W, Zhou X, Yang L, Zhao D
Neuropharmacology 2017 Sep 1;123:332-348
Neuropharmacology 2017 Sep 1;123:332-348
Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.
Shrestha S, Zhu J, Wang Q, Du X, Liu F, Jiang J, Song J, Xing J, Sun D, Hou Q, Peng Y, Zhao J, Sun X, Song X
International journal of oncology 2017 Oct;51(4):1249-1260
International journal of oncology 2017 Oct;51(4):1249-1260
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway.
Yan S, Wei X, Xu S, Sun H, Wang W, Liu L, Jiang X, Zhang Y, Che Y
Oncotarget 2017 Oct 6;8(46):80909-80922
Oncotarget 2017 Oct 6;8(46):80909-80922
Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats.
Bai J, Yu XJ, Liu KL, Wang FF, Jing GX, Li HB, Zhang Y, Huo CJ, Li X, Gao HL, Qi J, Kang YM
Toxicology and applied pharmacology 2017 Oct 15;333:100-109
Toxicology and applied pharmacology 2017 Oct 15;333:100-109
Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms.
Li F, Zhu Y, Wan Y, Xie X, Ke R, Zhai C, Pan Y, Yan X, Wang J, Shi W, Li M
European journal of pharmacology 2017 Nov 5;814:324-334
European journal of pharmacology 2017 Nov 5;814:324-334
Cooperative regulation of Gja1 expression by members of the AP-1 family cJun and cFos in TM3 Leydig and TM4 Sertoli cells.
Ghouili F, Martin LJ
Gene 2017 Nov 30;635:24-32
Gene 2017 Nov 30;635:24-32
2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.
Xu S, Liu J, Shi J, Wang Z, Ji L
Scientific reports 2017 Nov 28;7(1):16511
Scientific reports 2017 Nov 28;7(1):16511
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Ye J, Wei X, Shang Y, Pan Q, Yang M, Tian Y, He Y, Peng Z, Chen L, Chen W, Wang R
Oncogene 2017 Nov 16;36(46):6391-6407
Oncogene 2017 Nov 16;36(46):6391-6407
Overexpression of Rsf-1 correlates with poor survival and promotes invasion in non-small cell lung cancer.
Zhang X, Fu L, Xue D, Zhang X, Hao F, Xie L, He J, Gai J, Liu Y, Xu H, Li Q, Wang E
Virchows Archiv : an international journal of pathology 2017 May;470(5):553-560
Virchows Archiv : an international journal of pathology 2017 May;470(5):553-560
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Gong X, Yang Y, Huang L, Zhang Q, Wan RZ, Zhang P, Zhang B
International immunopharmacology 2017 May;46:124-132
International immunopharmacology 2017 May;46:124-132
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Gao Y, Li J, Xu X, Wang S, Yang Y, Zhou J, Zhang L, Zheng F, Li X, Wang B
International journal of obesity (2005) 2017 May;41(5):729-738
International journal of obesity (2005) 2017 May;41(5):729-738
E-Prostanoid 3 Receptor Mediates Sprouting Angiogenesis Through Suppression of the Protein Kinase A/β-Catenin/Notch Pathway.
Chen D, Tang J, Wan Q, Zhang J, Wang K, Shen Y, Yu Y
Arteriosclerosis, thrombosis, and vascular biology 2017 May;37(5):856-866
Arteriosclerosis, thrombosis, and vascular biology 2017 May;37(5):856-866
Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages.
Fang W, Bi D, Zheng R, Cai N, Xu H, Zhou R, Lu J, Wan M, Xu X
Scientific reports 2017 May 10;7(1):1663
Scientific reports 2017 May 10;7(1):1663
Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication.
Guedán A, Swieboda D, Charles M, Toussaint M, Johnston SL, Asfor A, Panjwani A, Tuthill TJ, Danahay H, Raynham T, Mousnier A, Solari R
Journal of virology 2017 May 1;91(9)
Journal of virology 2017 May 1;91(9)
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells.
Ma L, Sun P, Zhang JC, Zhang Q, Yao SL
International journal of molecular medicine 2017 Jul;40(1):31-38
International journal of molecular medicine 2017 Jul;40(1):31-38
Nrf2-Knockout Protects from Intestinal Injuries in C57BL/6J Mice Following Abdominal Irradiation with γ Rays.
Yang W, Sun Z, Yang B, Wang Q
International journal of molecular sciences 2017 Jul 31;18(8)
International journal of molecular sciences 2017 Jul 31;18(8)
Correction: Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, Jin N, Xie Z, Tan M, Lin SH, Geng M, Ding J, Huang M
The Journal of cell biology 2017 Jul 24;216(8):2597-8
The Journal of cell biology 2017 Jul 24;216(8):2597-8
Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells.
Li S, Pan Y, Ke R, Xie X, Zhai C, Shi W, Wang J, Yan X, Chai L, Wang Q, Zhang Q, Su X, Yang L, Gao L, Li M
Scientific reports 2017 Jul 20;7(1):6088
Scientific reports 2017 Jul 20;7(1):6088
The electrophilic character of quinones is essential for the suppression of Bach1.
Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y
Toxicology 2017 Jul 15;387:17-26
Toxicology 2017 Jul 15;387:17-26
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
Hu YH, Chen Q, Lu YX, Zhang JM, Lin C, Zhang F, Zhang WJ, Li XM, Zhang W, Li XN
Oncotarget 2017 Jul 11;8(28):46191-46203
Oncotarget 2017 Jul 11;8(28):46191-46203
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Hu YR, Ma H, Zou ZY, He K, Xiao YB, Wang Y, Feng M, Ye XL, Li XG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining.
Ly P, Teitz LS, Kim DH, Shoshani O, Skaletsky H, Fachinetti D, Page DC, Cleveland DW
Nature cell biology 2017 Jan;19(1):68-75
Nature cell biology 2017 Jan;19(1):68-75
Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer.
Zhong H, Xiao M, Zarkovic K, Zhu M, Sa R, Lu J, Tao Y, Chen Q, Xia L, Cheng S, Waeg G, Zarkovic N, Yin H
Free radical biology & medicine 2017 Jan;102:67-76
Free radical biology & medicine 2017 Jan;102:67-76
The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins.
You L, Liu H, Huang J, Xie W, Wei J, Ye X, Qian W
Oncotarget 2017 Jan 31;8(5):7777-7790
Oncotarget 2017 Jan 31;8(5):7777-7790
Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells.
Xie Q, Fan F, Wei W, Liu Y, Xu Z, Zhai L, Qi Y, Ye B, Zhang Y, Basu S, Zhao Z, Wu J, Xu P
Scientific reports 2017 Jan 23;7:41089
Scientific reports 2017 Jan 23;7:41089
Repression of YAP by NCTD disrupts NSCLC progression.
Guo J, Wu Y, Yang L, Du J, Gong K, Chen W, Dai J, Li X, Xi S
Oncotarget 2017 Jan 10;8(2):2307-2319
Oncotarget 2017 Jan 10;8(2):2307-2319
The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling.
Lai D, Gao J, Bi X, He H, Shi X, Weng S, Chen Y, Yang Y, Ye Y, Fu G
Journal of molecular medicine (Berlin, Germany) 2017 Feb;95(2):155-165
Journal of molecular medicine (Berlin, Germany) 2017 Feb;95(2):155-165
A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury.
Ren X, Li X, Jia L, Chen D, Hou H, Rui L, Zhao Y, Chen Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Feb;31(2):711-718
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Feb;31(2):711-718
Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells.
Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, Jin N, Xie Z, Tan M, Lin SH, Geng M, Ding J, Huang M
The Journal of cell biology 2017 Feb;216(2):409-424
The Journal of cell biology 2017 Feb;216(2):409-424
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.
Lu Y, Xie S, Zhang W, Zhang C, Gao C, Sun Q, Cai Y, Xu Z, Xiao M, Xu Y, Huang X, Wu X, Liu W, Wang F, Kang Y, Zhou T
Cell research 2017 Dec;27(12):1422-1440
Cell research 2017 Dec;27(12):1422-1440
Respiratory Syncytial Virus Nonstructural Protein 1 Blocks Glucocorticoid Receptor Nuclear Translocation by Targeting IPO13 and May Account for Glucocorticoid Insensitivity.
Xie J, Long X, Gao L, Chen S, Zhao K, Li W, Zhou N, Zang N, Deng Y, Ren L, Wang L, Luo Z, Tu W, Zhao X, Fu Z, Xie X, Liu E
The Journal of infectious diseases 2017 Dec 27;217(1):35-46
The Journal of infectious diseases 2017 Dec 27;217(1):35-46
Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells.
Wei X, Ye J, Shang Y, Chen H, Liu S, Liu L, Wang R
Oncotarget 2017 Dec 12;8(65):109301-109318
Oncotarget 2017 Dec 12;8(65):109301-109318
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, Kong W, Kong W
Redox biology 2017 Aug;12:987-1003
Redox biology 2017 Aug;12:987-1003
Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.
Tian Y, Li Z, Shen B, Zhang Q, Feng H
International immunopharmacology 2017 Apr;45:148-155
International immunopharmacology 2017 Apr;45:148-155
Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.
Lu Y, Wan J, Yang Z, Lei X, Niu Q, Jiang L, Passtoors WM, Zang A, Fraering PC, Wu F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1382-1397
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1382-1397
Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.
Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal RS, Artates JW, Tabet R, Wheeler VC, Bang AG, Cleveland DW, Lagier-Tourenne C
Neuron 2017 Apr 5;94(1):48-57.e4
Neuron 2017 Apr 5;94(1):48-57.e4
Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma.
Huang W, Zhou W, Li C, Yang Y, Shang YK, Chen C, Zhang J, Yao R, Wang P, Wen W, Liu HQ, Wang L, Li X, Bian H, Chen ZN
Oncotarget 2017 Apr 18;8(16):26288-26297
Oncotarget 2017 Apr 18;8(16):26288-26297
The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.
Fu J, Xia X, Liu Z, Wang Y, Wang Y, Shi Q, Song X, Song E, Song Y
Toxicology 2017 Apr 15;381:39-50
Toxicology 2017 Apr 15;381:39-50
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Nie H, Xue X, Liu G, Guan G, Liu H, Sun L, Zhao L, Wang X, Chen Z
Free radical research 2016;50(11):1200-1213
Free radical research 2016;50(11):1200-1213
Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway.
Huang X, He Z, Jiang X, Hou M, Tang Z, Zhen X, Liang Y, Ma J
PloS one 2016;11(3):e0151553
PloS one 2016;11(3):e0151553
Toll-like receptor 2-mediated MAPKs and NF-κB activation requires the GNAO1-dependent pathway in human mast cells.
Jin M, Yu B, Zhang W, Zhang W, Xiao Z, Mao Z, Lai Y, Lin D, Ma Q, Pan E, Zhang Y, Yu Y
Integrative biology : quantitative biosciences from nano to macro 2016 Sep 12;8(9):968-75
Integrative biology : quantitative biosciences from nano to macro 2016 Sep 12;8(9):968-75
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M, Lee YH, Bae SH
Free radical biology & medicine 2016 Oct;99:520-532
Free radical biology & medicine 2016 Oct;99:520-532
The absence of p53 during Human Cytomegalovirus infection leads to decreased UL53 expression, disrupting UL50 localization to the inner nuclear membrane, and thereby inhibiting capsid nuclear egress.
Kuan MI, O'Dowd JM, Fortunato EA
Virology 2016 Oct;497:262-278
Virology 2016 Oct;497:262-278
From the Cover: Tetrachlorobenzoquinone Exerts Neurological Proinflammatory Activity by Promoting HMGB1 Release, Which Induces TLR4 Clustering within the Lipid Raft.
Fu J, Shi Q, Song X, Liu Z, Wang Y, Wang Y, Song E, Song Y
Toxicological sciences : an official journal of the Society of Toxicology 2016 Oct;153(2):303-15
Toxicological sciences : an official journal of the Society of Toxicology 2016 Oct;153(2):303-15
Salusin-β contributes to vascular inflammation associated with pulmonary arterial hypertension in rats.
Xu T, Zhang Z, Liu T, Zhang W, Liu J, Wang W, Wang J
The Journal of thoracic and cardiovascular surgery 2016 Oct;152(4):1177-87
The Journal of thoracic and cardiovascular surgery 2016 Oct;152(4):1177-87
Regulation of a TGF-β1-CD147 self-sustaining network in the differentiation plasticity of hepatocellular carcinoma cells.
Wu J, Lu M, Li Y, Shang YK, Wang SJ, Meng Y, Wang Z, Li ZS, Chen H, Chen ZN, Bian H
Oncogene 2016 Oct 20;35(42):5468-5479
Oncogene 2016 Oct 20;35(42):5468-5479
P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain.
Tome ME, Herndon JM, Schaefer CP, Jacobs LM, Zhang Y, Jarvis CK, Davis TP
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Nov;36(11):1913-1928
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Nov;36(11):1913-1928
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
Zhang LK, Xin QL, Zhu SL, Wan WW, Wang W, Xiao G
Journal of virology 2016 Nov 15;90(22):10259-10270
Journal of virology 2016 Nov 15;90(22):10259-10270
The tumor suppressor PTEN has a critical role in antiviral innate immunity.
Li S, Zhu M, Pan R, Fang T, Cao YY, Chen S, Zhao X, Lei CQ, Guo L, Chen Y, Li CM, Jokitalo E, Yin Y, Shu HB, Guo D
Nature immunology 2016 Mar;17(3):241-9
Nature immunology 2016 Mar;17(3):241-9
REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.
Song Z, Zhu T, Zhou X, Barrow P, Yang W, Cui Y, Yang L, Zhao D
Oncotarget 2016 Mar 15;7(11):12035-52
Oncotarget 2016 Mar 15;7(11):12035-52
AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation.
Han X, Tai H, Wang X, Wang Z, Zhou J, Wei X, Ding Y, Gong H, Mo C, Zhang J, Qin J, Ma Y, Huang N, Xiang R, Xiao H
Aging cell 2016 Jun;15(3):416-27
Aging cell 2016 Jun;15(3):416-27
Go is required for the release of IL-8 and TNF-α, but not degranulation in human mast cells.
Yu Y, Huang Z, Mao Z, Zhang Y, Jin M, Chen W, Zhang W, Yu B, Zhang W, Alaster Lau HY
European journal of pharmacology 2016 Jun 5;780:115-21
European journal of pharmacology 2016 Jun 5;780:115-21
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Wang G, Yao J, Li Z, Zu G, Feng D, Shan W, Li Y, Hu Y, Zhao Y, Tian X
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons.
Jiang P, Gan M, Yen SH, Moussaud S, McLean PJ, Dickson DW
Acta neuropathologica 2016 Jul;132(1):77-91
Acta neuropathologica 2016 Jul;132(1):77-91
Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.
Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, Qian L, Liu C, Guo T, Zhang L, Wang X, Qian G, Li L, Ge J, Dai J, Xiong S, Zheng H
PLoS pathogens 2016 Jul;12(7):e1005764
PLoS pathogens 2016 Jul;12(7):e1005764
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, Xu Y, Zhao Y, Wang C, Peng J
Nutrients 2016 Jul 8;8(7)
Nutrients 2016 Jul 8;8(7)
Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation.
Gama Sosa MA, De Gasperi R, Hof PR, Elder GA
Scientific reports 2016 Jul 22;6:30267
Scientific reports 2016 Jul 22;6:30267
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
Su C, Shi Q, Song X, Fu J, Liu Z, Wang Y, Wang Y, Xia X, Song E, Song Y
Toxicology 2016 Jul 1;363-364:48-57
Toxicology 2016 Jul 1;363-364:48-57
MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes.
Chen LT, Hu MM, Xu ZS, Liu Y, Shu HB
Journal of immunology (Baltimore, Md. : 1950) 2016 Jul 1;197(1):199-207
Journal of immunology (Baltimore, Md. : 1950) 2016 Jul 1;197(1):199-207
Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IκB/NF-κB signaling.
Fu J, Shi Q, Song X, Xia X, Su C, Liu Z, Song E, Song Y
Environmental toxicology and pharmacology 2016 Jan;41:241-50
Environmental toxicology and pharmacology 2016 Jan;41:241-50
PRELP (proline/arginine-rich end leucine-rich repeat protein) promotes osteoblastic differentiation of preosteoblastic MC3T3-E1 cells by regulating the β-catenin pathway.
Li H, Cui Y, Luan J, Zhang X, Li C, Zhou X, Shi L, Wang H, Han J
Biochemical and biophysical research communications 2016 Feb 12;470(3):558-562
Biochemical and biophysical research communications 2016 Feb 12;470(3):558-562
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
Shi H, Shi A, Dong L, Lu X, Wang Y, Zhao J, Dai F, Guo X
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways.
Yan T, Yu X, Sun X, Meng D, Jia JM
Fitoterapia 2016 Dec;115:37-45
Fitoterapia 2016 Dec;115:37-45
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Song X, Shi Q, Liu Z, Wang Y, Wang Y, Song E, Song Y
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.
Shao W, Machamer CE, Espenshade PJ
Journal of lipid research 2016 Aug;57(8):1564-73
Journal of lipid research 2016 Aug;57(8):1564-73
The E3 Ubiquitin Ligase c-Cbl Inhibits Microglia-Mediated CNS Inflammation by Regulating PI3K/Akt/NF-κB Pathway.
Dong L, Li YZ, An HT, Wang YL, Chen SH, Qian YJ, Wang K, Zhen JL, Fan Z, Gong XL, Zheng Y, Wang XM
CNS neuroscience & therapeutics 2016 Aug;22(8):661-9
CNS neuroscience & therapeutics 2016 Aug;22(8):661-9
Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein.
Zhang J, Huang F, Tan L, Bai C, Chen B, Liu J, Liang J, Liu C, Zhang S, Lu G, Chen Y, Zhang H
Journal of virology 2016 Apr;90(8):3966-3980
Journal of virology 2016 Apr;90(8):3966-3980
Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells.
He W, Ye X, Huang X, Lel W, You L, Wang L, Chen X, Qian W
International journal of oncology 2016 Apr;48(4):1710-20
International journal of oncology 2016 Apr;48(4):1710-20
A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha.
Gesson K, Rescheneder P, Skoruppa MP, von Haeseler A, Dechat T, Foisner R
Genome research 2016 Apr;26(4):462-73
Genome research 2016 Apr;26(4):462-73
Identification and characterization of an endoplasmic reticulum localization motif.
Nie YW, Wang M, Zhang P, Huan L, Liu DJ
Biochemical and biophysical research communications 2016 Apr 22;473(1):249-254
Biochemical and biophysical research communications 2016 Apr 22;473(1):249-254
Mechanistic Study of the Phytocompound, 2- β -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches.
Shiau JY, Yin SY, Chang SL, Hsu YJ, Chen KW, Kuo TF, Feng CS, Yang NS, Shyur LF, Yang WC, Wen TN
Evidence-based complementary and alternative medicine : eCAM 2015;2015:475610
Evidence-based complementary and alternative medicine : eCAM 2015;2015:475610
The Overexpression of IQGAP1 and β-Catenin Is Associated with Tumor Progression in Hepatocellular Carcinoma In Vitro and In Vivo.
Jin X, Liu Y, Liu J, Lu W, Liang Z, Zhang D, Liu G, Zhu H, Xu N, Liang S
PloS one 2015;10(8):e0133770
PloS one 2015;10(8):e0133770
Demethylzeylasteral (T-96) Treatment Ameliorates Mice Lupus Nephritis Accompanied by Inhibiting Activation of NF-κB Pathway.
Hu Q, Yang C, Wang Q, Zeng H, Qin W
PloS one 2015;10(7):e0133724
PloS one 2015;10(7):e0133724
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver.
Liu S, Jing F, Yu C, Gao L, Qin Y, Zhao J
PloS one 2015;10(5):e0124951
PloS one 2015;10(5):e0124951
miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.
He K, Tong D, Zhang S, Cai D, Wang L, Yang Y, Gao L, Chang S, Guo B, Song T, Li A, Huang C
International journal of oncology 2015 Oct;47(4):1528-36
International journal of oncology 2015 Oct;47(4):1528-36
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, Chen H, Lu B, Sun Z, Wu S, Yang S, Li X, Ye X, Song E, Song Y
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3.
Zhu M, Fang T, Li S, Meng K, Guo D
Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 1;195(1):289-97
Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 1;195(1):289-97
Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma.
Wang F, Yang JL, Yu KK, Xu M, Xu YZ, Chen L, Lu YM, Fang HS, Wang XY, Hu ZQ, Li FF, Kan L, Luo J, Wang SY
Molecular cancer 2015 Jan 27;14(1):10
Molecular cancer 2015 Jan 27;14(1):10
Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells.
Mao Q, Xie Z, Wang X, Chen W, Ren M, Shang M, Lei H, Tian Y, Li S, Liang P, Chen T, Liang C, Xu J, Li X, Huang Y, Yu X
Parasitology research 2015 Feb;114(2):659-70
Parasitology research 2015 Feb;114(2):659-70
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
Shi Q, Song X, Fu J, Su C, Xia X, Song E, Song Y
International immunopharmacology 2015 Dec;29(2):722-729
International immunopharmacology 2015 Dec;29(2):722-729
The effects of focal adhesion kinase on the motility, proliferation and apoptosis of Caco2 and SMMC-7721 cells.
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Medical oncology (Northwood, London, England) 2015 Apr;32(4):125
Medical oncology (Northwood, London, England) 2015 Apr;32(4):125
WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis.
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Oncotarget 2015 Apr 30;6(12):10239-52
Oncotarget 2015 Apr 30;6(12):10239-52
Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3.
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Brain research 2015 Apr 24;1605:39-48
Brain research 2015 Apr 24;1605:39-48
CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDAC1-associated repression of C/EBPα.
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Journal of molecular cell biology 2014 Oct;6(5):368-79
Journal of molecular cell biology 2014 Oct;6(5):368-79
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
Ning Z, Wang A, Liang J, Xie Y, Liu J, Feng L, Yan Q, Wang Z
International journal of oncology 2014 Oct;45(4):1594-608
International journal of oncology 2014 Oct;45(4):1594-608
Role of α-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis.
Xia X, Su C, Fu J, Zhang P, Jiang X, Xu D, Hu L, Song E, Song Y
International immunopharmacology 2014 Oct;22(2):293-302
International immunopharmacology 2014 Oct;22(2):293-302
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
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Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/β-catenin signaling pathway.
Hu TH, Yao Y, Yu S, Han LL, Wang WJ, Guo H, Tian T, Ruan ZP, Kang XM, Wang J, Wang SH, Nan KJ
Cancer letters 2014 Nov 28;354(2):417-26
Cancer letters 2014 Nov 28;354(2):417-26
Pao Pereira Extract Suppresses Castration-Resistant Prostate Cancer Cell Growth, Survival, and Invasion Through Inhibition of NFκB Signaling.
Chang C, Zhao W, Xie B, Deng Y, Han T, Cui Y, Dai Y, Zhang Z, Gao J, Guo H, Yan J
Integrative cancer therapies 2014 May;13(3):249-58
Integrative cancer therapies 2014 May;13(3):249-58
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
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The Journal of biological chemistry 2014 May 2;289(18):12876-85
The Journal of biological chemistry 2014 May 2;289(18):12876-85
Oridonin induces NPM mutant protein translocation and apoptosis in NPM1c+ acute myeloid leukemia cells in vitro.
Li FF, Yi S, Wen L, He J, Yang LJ, Zhao J, Zhang BP, Cui GH, Chen Y
Acta pharmacologica Sinica 2014 Jun;35(6):806-13
Acta pharmacologica Sinica 2014 Jun;35(6):806-13
Vascular endothelial growth factor receptor-1 activation promotes migration and invasion of breast cancer cells through epithelial-mesenchymal transition.
Ning Q, Liu C, Hou L, Meng M, Zhang X, Luo M, Shao S, Zuo X, Zhao X
PloS one 2013;8(6):e65217
PloS one 2013;8(6):e65217
Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L.
Yang GD, Huang TJ, Peng LX, Yang CF, Liu RY, Huang HB, Chu QQ, Yang HJ, Huang JL, Zhu ZY, Qian CN, Huang BJ
PloS one 2013;8(10):e78355
PloS one 2013;8(10):e78355
Conditioned medium of Wnt/β-catenin signaling-activated olfactory ensheathing cells promotes synaptogenesis and neurite growth in vitro.
Yang Z, Wu Y, Zheng L, Zhang C, Yang J, Shi M, Feng D, Wu Z, Wang YZ
Cellular and molecular neurobiology 2013 Oct;33(7):983-90
Cellular and molecular neurobiology 2013 Oct;33(7):983-90
Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model.
Shan Y, Schoenfeld RA, Hayashi G, Napoli E, Akiyama T, Iodi Carstens M, Carstens EE, Pook MA, Cortopassi GA
Antioxidants & redox signaling 2013 Nov 1;19(13):1481-93
Antioxidants & redox signaling 2013 Nov 1;19(13):1481-93
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
Shi H, Dong L, Jiang J, Zhao J, Zhao G, Dang X, Lu X, Jia M
Toxicology 2013 Jan 7;303:107-14
Toxicology 2013 Jan 7;303:107-14
Adeno-associated virus Rep78 restricts adenovirus E1B55K-mediated p53 nuclear exportation.
Wang J, Li W, Wang R, Xue J, Chen J
Acta biochimica et biophysica Sinica 2013 Feb;45(2):135-40
Acta biochimica et biophysica Sinica 2013 Feb;45(2):135-40
Induction of apoptosis in infantile hemangioma endothelial cells by propranolol.
Tu JB, Ma RZ, Dong Q, Jiang F, Hu XY, Li QY, Pattar P, Zhang H
Experimental and therapeutic medicine 2013 Aug;6(2):574-578
Experimental and therapeutic medicine 2013 Aug;6(2):574-578
Proteomic analysis of mitochondria from infantile hemangioma endothelial cells treated with sodium morrhuate and its liposomal formulation.
Tu JB, Dong Q, Hu XY, Jiang F, Ma RZ, He LY, Yang ZQ
Journal of biochemical and molecular toxicology 2012 Sep;26(9):374-80
Journal of biochemical and molecular toxicology 2012 Sep;26(9):374-80
1,2,3,4,6-penta-O-galloyl-β-D-glucose protects PC12 Cells from MPP(+)-mediated cell death by inducing heme oxygenase-1 in an ERK- and Akt-dependent manner.
Chen H, Li H, Cao F, Zhen L, Bai J, Yuan S, Mei Y
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2012 Oct;32(5):737-745
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2012 Oct;32(5):737-745
Hypoxia increases CX3CR1 expression via HIF-1 and NF‑κB in androgen-independent prostate cancer cells.
Xiao LJ, Chen YY, Lin P, Zou HF, Lin F, Zhao LN, Li D, Guo L, Tang JB, Zheng XL, Yu XG
International journal of oncology 2012 Nov;41(5):1827-36
International journal of oncology 2012 Nov;41(5):1827-36
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W, Shu HB
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 17;109(29):11770-5
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 17;109(29):11770-5
Activation of the Wnt/β-catenin signaling pathway is associated with glial proliferation in the adult spinal cord of ALS transgenic mice.
Chen Y, Guan Y, Liu H, Wu X, Yu L, Wang S, Zhao C, Du H, Wang X
Biochemical and biophysical research communications 2012 Apr 6;420(2):397-403
Biochemical and biophysical research communications 2012 Apr 6;420(2):397-403
Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kappaB AND AP-1 through inhibition of MAPKS and AKT/IkappaBalpha signaling pathways in macrophages.
Yeh JL, Hsu JH, Hong YS, Wu JR, Liang JC, Wu BN, Chen IJ, Liou SF
International journal of immunopathology and pharmacology 2011 Apr-Jun;24(2):345-56
International journal of immunopathology and pharmacology 2011 Apr-Jun;24(2):345-56
KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways.
Yeh JL, Hsu JH, Wu PJ, Liou SF, Liu CP, Chen IJ, Wu BN, Dai ZK, Wu JR
British journal of pharmacology 2010 Mar;159(5):1151-60
British journal of pharmacology 2010 Mar;159(5):1151-60
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12987-1-AP(LMNB1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using LMNB1 antibody 12987-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-LMNB1 (IP:12987-1-AP, 3ug; Detection:12987-1-AP 1:1000) with HeLa cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 12987-1-AP(LMNB1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
