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- References [336]
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- Product number
- 66095-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#66095-1-Ig, RRID:AB_11232208
- Product name
- Lamin B1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Lamin B1 antibody (Cat. #66095-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3C10G12
- Vial size
- 150ul
Submitted references Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis.
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway.
DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover.
Peripherally targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels.
IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA viruses.
Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis.
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation.
RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
Rag-GTPase-TFEB/TFE3 axis controls B cell mitochondrial fitness and humoral immunity independent of mTORC1.
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging.
The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.
IL-35 ameliorates lipopolysaccharide-induced endothelial dysfunction by inhibiting endothelial-to-mesenchymal transition.
Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity.
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies.
Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis.
SMYD5 is a regulator of the mild hypothermia response.
Cysteine and glycine-rich protein 2 retards platelet-derived growth factor-BB-evoked phenotypic transition of airway smooth muscle cells by decreasing YAP/TAZ activity.
Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-κB pathway.
Unveiling the immunomodulatory mechanism of polysaccharides from Polygonum cyrtonema based on RNA-seq.
Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT/GSK3β/NRF2/GPX4 axis.
Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases.
Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells.
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
FOXP3(+) regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity.
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling.
Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway.
PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury.
Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells.
Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action.
CircNOP14 increases the radiosensitivity of hepatocellular carcinoma via inhibition of Ku70-dependent DNA damage repair.
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
Mind the Viscous Modulus: The Mechanotransductive Response to the Viscous Nature of Isoelastic Matrices Regulates Stem Cell Chondrogenesis.
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions.
TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis.
Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability.
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control.
Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns.
Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis.
Denervation aggravates renal ischemia reperfusion injury via BMAL1-mediated Nrf2/ARE pathway.
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Molecular mechanism by which RRM2-inhibitor (cholagogue osalmid) plus bafilomycin A1 cause autophagic cell death in multiple myeloma.
Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma.
Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis.
Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma.
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export.
Regulatory architecture of housekeeping genes is driven by promoter assemblies.
The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization.
IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma.
Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation.
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells.
YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells.
Disruption of the ADAM17/NF-κB feedback loop in astrocytes ameliorates HIV-1 Tat-induced inflammatory response and neuronal death.
The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.
Single cell RNA-seq resolution revealed CCR1(+)/SELL(+)/XAF(+) CD14 monocytes mediated vascular endothelial cell injuries in Kawasaki disease and COVID-19.
Charged multivesicular body protein 2B ameliorates biliary injury in the liver from donation after cardiac death rats via autophagy with air-oxygenated normothermic machine perfusion.
Anti-oxidative-initiated cognitive impairment amelioration in Alzheimer's disease model rats through preventive transcutaneous electrical acupoint stimulation.
Role of ionizing radiation activated NRF2 in lung cancer radioresistance.
SMYD3 drives the proliferation in gastric cancer cells via reducing EMP1 expression in an H4K20me3-dependent manner.
Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice.
SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/β-catenin signaling pathway.
Metformin synergistically enhances the antitumour activity of Lenvatinib in hepatocellular carcinoma by altering AKT-FOXO3 signalling pathway.
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Decreased lamin A and B1 expression results in nuclear enlargement in serous ovarian carcinoma, whereas lamin A-expressing tumor cells metastasize to lymph nodes.
Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway.
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis.
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury.
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Absence of indoleamine 2,3‑dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice.
β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage.
Influence of RRM, RGG and Potential Phosphorylated Sites in Cold-Inducible Protein RBM3 on its Subcellular Localization and Neuroprotective Effects.
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
The Integrator complex regulates microRNA abundance through RISC loading.
UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer.
FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway.
The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells.
Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells.
Conessine inhibits enveloped viruses replication through up-regulating cholesterol level.
Function of m(5)C RNA methyltransferase NOP2 in high-grade serous ovarian cancer.
A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity.
HIV-1 subtype B Tat enhances NOTCH3 signaling in astrocytes to mediate oxidative stress, inflammatory response, and neuronal apoptosis.
Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin.
Characterizing microglial senescence: Tau as a key player.
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation.
HHEX suppresses advanced thyroid cancer by interacting with TLE3.
Carteolol triggers senescence via activation of β-arrestin-ERK-NOX4-ROS pathway in human corneal endothelial cells in vitro.
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats.
LPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis.
Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway.
Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice.
Allyl methyl trisulfide protected against LPS-induced acute lung injury in mice via inhibition of the NF-κB and MAPK pathways.
Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B-Lamin B1 Interaction in Alcoholic Fatty Liver Disease.
Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway.
The Protective Effect of Evodiamine in Osteoarthritis: An In Vitro and In Vivo Study in Mice Model.
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Hypoxic Cell-Derived Extracellular Vesicles Aggravate Rectal Injury Following Radiotherapy via MiR-122-5p.
Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1.
RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ.
Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe.
Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte.
A Novel, Fully Spliced, Accessory Gene in Equine Lentivirus with Distinct Rev-Responsive Element.
Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation.
GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis.
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression.
Ultraviolet B irradiation induces senescence of human corneal endothelial cells in vitro by DNA damage response and oxidative stress.
Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells.
Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage.
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Free and Bound Phenolics of Laird Lentil (Lens culinaris) Hulls and the Anti-inflammatory Activity of their Digestive Products via Crosstalk between NF-κB and Keap1-Nrf2 Signaling Pathways in HT-29 Cells.
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.
Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation.
Exposure to Multiwall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis.
BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis.
Major Vault Protein Prevents Atherosclerotic Plaque Destabilization by Suppressing Macrophage ASK1-JNK Signaling.
Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP(+)-induced oxidative stress.
Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner.
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit.
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.
Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition.
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs.
NPM1 promotes cell proliferation by targeting PRDX6 in colorectal cancer.
Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription.
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
TRIM62 silencing represses the proliferation and invasion and increases the chemosensitivity of hepatocellular carcinoma cells by affecting the NF-κB pathway.
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation.
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
DNA Repair Factor Poly(ADP-Ribose) Polymerase 1 Is a Proviral Factor in Hepatitis B Virus Covalently Closed Circular DNA Formation.
TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1.
METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice.
3-(3-Hydroxyphenyl)propionic acid, a microbial metabolite of quercetin, inhibits monocyte binding to endothelial cells via modulating E-selectin expression.
Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection.
Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes.
The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
RETRACTED: TRIM21 deficiency confers protection from OGD/R-induced oxidative and inflammatory damage in cultured hippocampal neurons through regulation of the Keap1/Nrf2 pathway.
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction.
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
HIV-1 Tat drives the Fabp4/NF-κB feedback loop in microglia to mediate inflammatory response and neuronal apoptosis.
Blockade of CBX4-mediated β-catenin SUMOylation attenuates airway epithelial barrier dysfunction in asthma.
Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3.
Onset of p53/NF-κB signaling crosstalk in human melanoma cells in response to anti-cancer theabrownin.
METTL3 preferentially enhances non-m(6)A translation of epigenetic factors and promotes tumourigenesis.
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export.
Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism.
Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Antioxidant Activity of Acanthopanax senticosus Flavonoids in H(2)O(2)-Induced RAW 264.7 Cells and DSS-Induced Colitis in Mice.
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.
PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway.
Arid4b alters cell cycle and cell death dynamics during mouse embryonic stem cell differentiation.
Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1.
Protective Effect of Jiang Tang Xiao Ke Granules against Skeletal Muscle IR via Activation of the AMPK/SIRT1/PGC-1α Signaling Pathway.
GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy.
Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Transcription Coactivator BCL3 Acts as a Potential Regulator of Lipid Metabolism Through the Effects on Inflammation.
Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.
PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress.
Angelica Polysaccharide Antagonizes 5-FU-Induced Oxidative Stress Injury to Reduce Apoptosis in the Liver Through Nrf2 Pathway.
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration.
MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling.
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation.
Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization.
ATRX proximal protein associations boast roles beyond histone deposition.
DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma.
KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.
Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation.
TET2 Inhibits PD-L1 Gene Expression in Breast Cancer Cells through Histone Deacetylation.
The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury.
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
miR-142-3p reduces the viability of human cervical cancer cells by negatively regulating the cytoplasmic localization of HMGB1.
Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway.
PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells.
ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.
Inhibitory activity of flavonoids from Ephedrae Herba on hypoxia signaling in PANC-1 cells and the evaluation of their mechanisms.
Molecular Mechanism of Platelet-Derived Growth Factor (PDGF)-BB-Mediated Protection Against MPP(+) Toxicity in SH-SY5Y Cells.
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP.
Spermidine at supraphysiological doses induces oxidative stress and granulosa cell apoptosis in mouse ovaries.
Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats.
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer.
Regulatory role of DEPTOR‑mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma.
Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair.
Abnormal nitration and S-sulfhydration modification of Sp1-CSE-H(2)S pathway trap the progress of hyperhomocysteinemia into a vicious cycle.
Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux.
Increased long noncoding RNA LINK-A contributes to rheumatoid synovial inflammation and aggression.
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate.
The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation.
Interaction of NEP with G Protein Pathway Suppressor 2 Facilitates Influenza A Virus Replication by Weakening the Inhibition of GPS2 to RNA Synthesis and Ribonucleoprotein Assembly.
Discovering the Mechanisms of Wikstroelide E as a Potential HIV-Latency-Reversing Agent by Transcriptome Profiling.
Seco-type β-Apocarotenoid Generated by β-Carotene Oxidation Exerts Anti-inflammatory Effects against Activated Macrophages.
Deletion of LBR N-terminal domains recapitulates Pelger-Huet anomaly phenotypes in mouse without disrupting X chromosome inactivation.
Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9(+) cells to prevent the development of liver cancer in a mouse model.
Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator.
Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.
β-Actin facilitates etoposide-induced p53 nuclear import.
Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway.
Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway.
Metformin Ameliorates Gestational Diabetes Mellitus-Induced Endothelial Dysfunction via Downregulation of p65 and Upregulation of Nrf2.
SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β-catenin signaling pathway.
Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas.
Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells.
Evaluation of cancer-derived myocardial impairments using a mouse model.
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice.
Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer.
Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis.
Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity.
Arsenic trioxide induces gasdermin E mediated pyroptosis in astroglioma cells.
23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9.
Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
Polymorphisms in Human APOBEC3H Differentially Regulate Ubiquitination and Antiviral Activity.
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging.
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABA(A) receptors.
Oncogenic role of TYRO3 receptor tyrosine kinase in the progression of pancreatic cancer.
Ribosome 18S m(6)A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.
Tet2 regulates Barx2 expression in undifferentiated and early differentiated mouse embryonic stem cells.
The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43.
BPTES inhibits anthrax lethal toxin-induced inflammatory response.
Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly.
Effects of peptidoglycan on the development of steatohepatitis.
OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3.
CACYBP Enhances Cytoplasmic Retention of P27(Kip1) to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.
Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage.
Deficiency of emerin contributes differently to the pathogenesis of skeletal and cardiac muscles in LmnaH222P/H222P mutant mice.
Nigericin Promotes NLRP3-Independent Bacterial Killing in Macrophages.
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P(2) and extended synaptotagmins.
Probiotic effect on Helicobacter pylori attachment and inhibition of inflammation in human gastric epithelial cells.
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
ACLY facilitates colon cancer cell metastasis by CTNNB1.
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.
Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance.
USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.
The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING.
The phosphorylation of Tudor-SN mediated by JNK is involved in the regulation of milk protein synthesis induced by prolactin in BMECs.
Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport.
S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells.
Multi-omic Analyses Reveal Minimal Impact of the CRISPR-Cas9 Nuclease on Cultured Human Cells.
Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways.
NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ.
Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-κB and activating Nrf2/HO-1 signaling pathways.
The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
SUMOylation is required for PIPK1γ-driven keratinocyte migration and growth.
Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation.
Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.
Fibrinopeptide A induces C-reactive protein expression through the ROS-ERK1/2/p38-NF-κB signal pathway in the human umbilical vascular endothelial cells.
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.
Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts.
Asiatic Acid (AA) Sensitizes Multidrug-Resistant Human Lung Adenocarcinoma A549/DDP Cells to Cisplatin (DDP) via Downregulation of P-Glycoprotein (MDR1) and Its Targets.
NLRP12 Promotes Mouse Neutrophil Differentiation through Regulation of Non-canonical NF-κB and MAPK(ERK1/2) Signaling.
Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway.
TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway.
Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling.
Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.
Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress.
The E3 ubiquitin ligase MuRF2 attenuates LPS-induced macrophage activation by inhibiting production of inflammatory cytokines and migration.
Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/β-catenin and osteoprotegerin/receptor activator for nuclear factor-κB ligand/cathepsin K signaling in ovariectomized rats.
Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization.
KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer.
MTEP impedes the neuronal polarization and the activity of the Akt-NF-κB pathway in rat hippocampal neurons.
Quercetin protects against atherosclerosis by inhibiting dendritic cell activation.
Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags.
Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2.
Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.
Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy.
HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.
The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription.
The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.
HMGB1 Enhances Drug Resistance and Promotes In Vivo Tumor Growth of Lung Cancer Cells.
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation.
The long noncoding RNA ASNR regulates degradation of Bcl-2 mRNA through its interaction with AUF1.
Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity.
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice.
Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via nuclear factor-κB activation.
Astrocyte elevated gene-1 promotes progression of cervical squamous cell carcinoma by inducing epithelial-mesenchymal transition via Wnt signaling.
Rho GDIalpha Modulates Rabbit Trophoblast Stem Cell Survival and Migration.
Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication.
Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells.
Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells.
Chen N, Xu X, Guo Y, Zhao M, Li Y, Zhou T, Zhang X, Gao J, Zhu F, Guo C, Shi Y, Wang Q, Wu W, Zhang L, Li Y
Research (Washington, D.C.) 2024;7:0400
Research (Washington, D.C.) 2024;7:0400
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Zhao J, Chen C, Ge L, Jiang Z, Hu Z, Yin L
Frontiers in immunology 2024;15:1386780
Frontiers in immunology 2024;15:1386780
NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway.
Sun X, Dong M, Li J, Sun Y, Gao Y, Wang Y, Du L, Liu Y, Ji K, He N, Wang J, Zhang M, Song H, Xu C, Liu Q
Theranostics 2024;14(2):681-698
Theranostics 2024;14(2):681-698
DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.
Shokrollahi M, Stanic M, Hundal A, Chan JNY, Urman D, Jordan CA, Hakem A, Espin R, Hao J, Krishnan R, Maass PG, Dickson BC, Hande MP, Pujana MA, Hakem R, Mekhail K
Nature structural & molecular biology 2024 Sep;31(9):1319-1330
Nature structural & molecular biology 2024 Sep;31(9):1319-1330
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
Liu J, Gao L, Zhou N, Jiang Z, Che S, Deng Y, Zang N, Ren L, Xie X, Xie J, Liu E
Virology 2024 May;593:110018
Virology 2024 May;593:110018
Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover.
Foo MXR, Ong PF, Yap ZX, Maric M, Bong CJS, Dröge P, Burke B, Dreesen O
Aging cell 2024 May;23(5):e14105
Aging cell 2024 May;23(5):e14105
Peripherally targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels.
Shin SM, Itson-Zoske B, Fan F, Xiao Y, Qiu C, Cummins TR, Hogan QH, Yu H
The Journal of clinical investigation 2024 May 9;134(13)
The Journal of clinical investigation 2024 May 9;134(13)
IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA viruses.
Cruz-Rivera PC, Eitson JL, Schoggins JW
bioRxiv : the preprint server for biology 2024 May 5;
bioRxiv : the preprint server for biology 2024 May 5;
Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis.
Li H, Ni H, Li Y, Zhou A, Qin X, Li Y, Che L, Mo H, Qin C, Li J
Cell death discovery 2024 May 13;10(1):227
Cell death discovery 2024 May 13;10(1):227
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation.
Peng Z, Li XJ, Zhou Y, Zhang JT, Zhu Q, Sun JQ, Hang CH, Li W, Zhang QR, Zhuang Z
Free radical biology & medicine 2024 Mar;215:79-93
Free radical biology & medicine 2024 Mar;215:79-93
RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
He S, Lu M, Zhang L, Wang Z
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166996
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166996
Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
Ma H, Suleman M, Zhang F, Cao T, Wen S, Sun D, Chen L, Jiang B, Wang Y, Lin F, Wang J, Li B, Li Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2301476
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2301476
Rag-GTPase-TFEB/TFE3 axis controls B cell mitochondrial fitness and humoral immunity independent of mTORC1.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik JO, Chen YM, Raybuck AL, Billadeau D, Shapiro V, Springer W, Sun J, Boothby MR, Zeng H
Research square 2024 Mar 29;
Research square 2024 Mar 29;
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging.
Zhou Z, Yao J, Wu D, Huang X, Wang Y, Li X, Lu Q, Qiu Y
Immunity 2024 Mar 12;57(3):513-527.e6
Immunity 2024 Mar 12;57(3):513-527.e6
The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik JO, Chen YM, Raybuck AL, Billadeau D, Shapiro V, Springer W, Sun J, Boothby MR, Zeng H
bioRxiv : the preprint server for biology 2024 Mar 12;
bioRxiv : the preprint server for biology 2024 Mar 12;
IL-35 ameliorates lipopolysaccharide-induced endothelial dysfunction by inhibiting endothelial-to-mesenchymal transition.
Feng J, Li K, Xie F, Han L, Wu Y
International immunopharmacology 2024 Mar 10;129:111567
International immunopharmacology 2024 Mar 10;129:111567
Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity.
Feng S, Wang D, Jin Y, Huang S, Liang T, Sun W, Du X, Zhuo L, Shan C, Zhang W, Jing T, Zhao S, Hong R, You L, Liu G, Chen L, Ye D, Li X, Yang Y
Cell reports 2024 Jun 25;43(6):114300
Cell reports 2024 Jun 25;43(6):114300
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
Xu S, Wang N, Zuccaro MV, Gerhardt J, Iyyappan R, Scatolin GN, Jiang Z, Baslan T, Koren A, Egli D
Nature communications 2024 Jun 19;15(1):5247
Nature communications 2024 Jun 19;15(1):5247
Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies.
Ye Z, Ge Z, Yang S, Hu T, Ye Q, Chen H
Phytotherapy research : PTR 2024 Jul;38(7):3509-3524
Phytotherapy research : PTR 2024 Jul;38(7):3509-3524
Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis.
Xu Z, Li J, Zhou K, Wang K, Hu H, Hu Y, Gao Y, Luo Z, Huang J
Journal of ethnopharmacology 2024 Jul 15;329:118162
Journal of ethnopharmacology 2024 Jul 15;329:118162
SMYD5 is a regulator of the mild hypothermia response.
Rafnsdottir S, Jang K, Halldorsdottir ST, Vinod M, Tomasdottir A, Möller K, Halldorsdottir K, Reynisdottir T, Atladottir LH, Allison KE, Ostacolo K, He J, Zhang L, Northington FJ, Magnusdottir E, Chavez-Valdez R, Anderson KJ, Bjornsson HT
bioRxiv : the preprint server for biology 2024 Jul 12;
bioRxiv : the preprint server for biology 2024 Jul 12;
Cysteine and glycine-rich protein 2 retards platelet-derived growth factor-BB-evoked phenotypic transition of airway smooth muscle cells by decreasing YAP/TAZ activity.
Wang H, Zhang Y, Zhong B, Geng Y, Hao J, Jin Q, Hou W
Cell biochemistry and function 2024 Jan;42(1):e3896
Cell biochemistry and function 2024 Jan;42(1):e3896
Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-κB pathway.
Zhang J, Tu Y, Wei J, Zheng R, Shao J, Chen Q, Liang G, Ying H, Han X, Shi Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166911
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166911
Unveiling the immunomodulatory mechanism of polysaccharides from Polygonum cyrtonema based on RNA-seq.
Shan J, Ma W, Guo Y, Chang X, Xie J, Chen Y, Hu X, Yu Q
Food research international (Ottawa, Ont.) 2024 Jan;175:113755
Food research international (Ottawa, Ont.) 2024 Jan;175:113755
Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT/GSK3β/NRF2/GPX4 axis.
Huang W, Wen F, Yang P, Li Y, Li Q, Shu P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155220
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155220
Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases.
Fang ZE, Wang Y, Bian S, Qin S, Zhao H, Wen J, Liu T, Ren L, Li Q, Shi W, Zhao J, Yang H, Peng R, Wang Q, Bai Z, Xu G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155159
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155159
Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells.
Xie L, Li R, Zhang J, Li H, Gao X, Zhang M
Journal of agricultural and food chemistry 2024 Jan 31;72(4):2135-2144
Journal of agricultural and food chemistry 2024 Jan 31;72(4):2135-2144
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Wang R, Zeng J, Chen L, Sun L, Wang Y, Xu J, He X
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
FOXP3(+) regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity.
Liu X, Zhang W, Han Y, Cheng H, Liu Q, Ke S, Zhu F, Lu Y, Dai X, Wang C, Huang G, Su B, Zou Q, Li H, Zhao W, Xiao L, Lu L, Tong X, Pan F, Li H, Li B
Nature communications 2024 Jan 2;15(1):122
Nature communications 2024 Jan 2;15(1):122
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
Xu Y, Liu X, Zeng W, Zhu Y, Dong J, Wu F, Chen C, Sharma S, Lin Y
Life science alliance 2024 Feb;7(2)
Life science alliance 2024 Feb;7(2)
ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling.
He Y, Shi Q, Ling Y, Guo H, Fei Y, Wu R, Tang C, Zhang X, Yao L
Cell death and differentiation 2024 Feb;31(2):203-216
Cell death and differentiation 2024 Feb;31(2):203-216
Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway.
Hu R, Wu F, Zheng YQ
Redox report : communications in free radical research 2024 Dec;29(1):2332038
Redox report : communications in free radical research 2024 Dec;29(1):2332038
PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury.
Zhao H, Liu D, Sun S, Yu J, Bian X, Cheng X, Yang Q, Yu Y, Xu Z
Free radical biology & medicine 2024 Aug 20;221:188-202
Free radical biology & medicine 2024 Aug 20;221:188-202
Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells.
Albuquerque-Souza E, Shelling B, Jiang M, Xia XJ, Rattanaprukskul K, Sahingur SE
Molecular oral microbiology 2024 Apr;39(2):29-39
Molecular oral microbiology 2024 Apr;39(2):29-39
Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action.
Yamamotoya T, Ohata Y, Akasaka Y, Hasei S, Inoue MK, Nakatsu Y, Kanna M, Yamazaki H, Kushiyama A, Fujishiro M, Ono H, Sakoda H, Yamada T, Ishihara H, Asano T
PNAS nexus 2024 Apr;3(4):pgae150
PNAS nexus 2024 Apr;3(4):pgae150
CircNOP14 increases the radiosensitivity of hepatocellular carcinoma via inhibition of Ku70-dependent DNA damage repair.
Lin L, Hu P, Luo M, Chen X, Xiao M, Zhong Z, Peng S, Chen G, Yang G, Zhang F, Zhang Y
International journal of biological macromolecules 2024 Apr;264(Pt 2):130541
International journal of biological macromolecules 2024 Apr;264(Pt 2):130541
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
Zhang R, Guan S, Meng Z, Zhang D, Lu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
Mind the Viscous Modulus: The Mechanotransductive Response to the Viscous Nature of Isoelastic Matrices Regulates Stem Cell Chondrogenesis.
Walker M, Pringle EW, Ciccone G, Oliver-Cervelló L, Tassieri M, Gourdon D, Cantini M
Advanced healthcare materials 2024 Apr;13(9):e2302571
Advanced healthcare materials 2024 Apr;13(9):e2302571
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions.
Cong J, Liu P, Han Z, Ying W, Li C, Yang Y, Wang S, Yang J, Cao F, Shen J, Zeng Y, Bai Y, Zhou C, Ye L, Zhou R, Guo C, Cang C, Kasper DL, Song X, Dai L, Sun L, Pan W, Zhu S
Immunity 2024 Apr 9;57(4):876-889.e11
Immunity 2024 Apr 9;57(4):876-889.e11
TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis.
Li Y, Luan S, Ruan C, Li W, Zhang X, Ran Z, Bi W, Tong Y, Gao L, Zhao J, Li Y, He Z
Biochemical and biophysical research communications 2024 Apr 16;704:149723
Biochemical and biophysical research communications 2024 Apr 16;704:149723
Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability.
Authier F, Ondruskova N, Ferenbach AT, McNeilly AD, van Aalten DMF
Disease models & mechanisms 2024 Apr 1;17(4)
Disease models & mechanisms 2024 Apr 1;17(4)
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control.
Chiu TY, Lo CH, Lin YH, Lai YD, Lin SS, Fang YT, Huang WS, Huang SY, Tsai PY, Yang FH, Chong WM, Wu YC, Tsai HC, Liu YW, Hsu CL, Liao JC, Wang WJ
Communications biology 2023 Sep 5;6(1):911
Communications biology 2023 Sep 5;6(1):911
Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns.
Pérez-Berlanga M, Wiersma VI, Zbinden A, De Vos L, Wagner U, Foglieni C, Mallona I, Betz KM, Cléry A, Weber J, Guo Z, Rigort R, de Rossi P, Manglunia R, Tantardini E, Sahadevan S, Stach O, Hruska-Plochan M, Allain FH, Paganetti P, Polymenidou M
The EMBO journal 2023 Sep 4;42(17):e111719
The EMBO journal 2023 Sep 4;42(17):e111719
Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis.
Li Z, Chen Y, Jiang X, Lu P, Wang C, Li Z, Yu X, Yang Z, Ma S, Du S, Tai Z, Li X, Zhang S, Jiang Y, Qin C
Journal of medicinal chemistry 2023 Sep 28;66(18):12966-12989
Journal of medicinal chemistry 2023 Sep 28;66(18):12966-12989
Denervation aggravates renal ischemia reperfusion injury via BMAL1-mediated Nrf2/ARE pathway.
Dong C, Li J, Tang Q, Wang Y, Zeng C, Du L, Sun Q
Archives of biochemistry and biophysics 2023 Sep 15;746:109736
Archives of biochemistry and biophysics 2023 Sep 15;746:109736
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Huangfu N, Ma H, Tian M, Zhang J, Wang Y, Li Z, Chen X, Cui H
Inflammation 2023 Oct;46(5):1725-1738
Inflammation 2023 Oct;46(5):1725-1738
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Yang J, Li L, Li C, Chen W, Liu Y, Luo S, Zhao C, Han Y, Yang M, Zhao H, Jiang N, Xi Y, Tang C, Cai J, Xiao L, Liu H, Sun L
Cell death & disease 2023 Oct 4;14(10):649
Cell death & disease 2023 Oct 4;14(10):649
Molecular mechanism by which RRM2-inhibitor (cholagogue osalmid) plus bafilomycin A1 cause autophagic cell death in multiple myeloma.
Guo S, Xu Z, Feng Q, Zhang H, Yu D, Li B, Hu K, Gao X, Zhang Q, Yi H, Wu X, Song D, Zhu H, Cai H, Peng Y, Zhu W, Shi J
Archives of biochemistry and biophysics 2023 Oct 1;747:109771
Archives of biochemistry and biophysics 2023 Oct 1;747:109771
Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma.
Boulos JC, Omer EA, Rigano D, Formisano C, Chatterjee M, Leich E, Klauck SM, Shan LT, Efferth T
Acta pharmacologica Sinica 2023 Nov;44(11):2265-2281
Acta pharmacologica Sinica 2023 Nov;44(11):2265-2281
Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis.
Huang X, Li X, Shen H, Zhao Y, Zhou Z, Wang Y, Yao J, Xue K, Wu D, Qiu Y
Nature communications 2023 Nov 4;14(1):7102
Nature communications 2023 Nov 4;14(1):7102
Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma.
Wang J, Zhang X, Ma X, Chen D, Cai M, Xiao L, Li J, Huang Z, Huang Y, Lian Y
Journal of experimental & clinical cancer research : CR 2023 Nov 16;42(1):303
Journal of experimental & clinical cancer research : CR 2023 Nov 16;42(1):303
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ
Nature communications 2023 Nov 1;14(1):6770
Nature communications 2023 Nov 1;14(1):6770
Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export.
Huang J, Tan X, Liu Y, Jiang K, Luo J
Molecular carcinogenesis 2023 May;62(5):700-715
Molecular carcinogenesis 2023 May;62(5):700-715
Regulatory architecture of housekeeping genes is driven by promoter assemblies.
Dejosez M, Dall'Agnese A, Ramamoorthy M, Platt J, Yin X, Hogan M, Brosh R, Weintraub AS, Hnisz D, Abraham BJ, Young RA, Zwaka TP
Cell reports 2023 May 30;42(5):112505
Cell reports 2023 May 30;42(5):112505
The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization.
Skory RM, Moverley AA, Ardestani G, Alvarez Y, Domingo-Muelas A, Pomp O, Hernandez B, Tetlak P, Bissiere S, Stern CD, Sakkas D, Plachta N
Nature communications 2023 May 29;14(1):3101
Nature communications 2023 May 29;14(1):3101
IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma.
Zhang X, Wang G, Gong Y, Zhao L, Song P, Zhang H, Zhang Y, Ju H, Wang X, Wang B, Ren H, Zhu X, Dong Y
iScience 2023 May 19;26(5):106639
iScience 2023 May 19;26(5):106639
Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation.
He X, Zhao J, Adilijiang A, Hong P, Chen P, Lin X, Xie J, Du Y, Liu Y, Lin L, Jin HY, Hong Y, Liu WH, Xiao C
Cellular & molecular immunology 2023 Mar;20(3):277-291
Cellular & molecular immunology 2023 Mar;20(3):277-291
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
Zhang Y, He B, Zhang D, Zhang Y, Chen C, Zhang W, Yang S, Yao M, Cui G, Gu J, Wang T, Lin Z, Fan Y, Xiong Z, Hao Y
Cell reports 2023 Mar 28;42(3):112188
Cell reports 2023 Mar 28;42(3):112188
DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells.
Li W, Liu S, Wang C, Cui L, Zhao X, Liu W, Zhang R, Li Z
BMC cancer 2023 Mar 18;23(1):255
BMC cancer 2023 Mar 18;23(1):255
YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells.
Wang P, Huang L, Yang F, Chen W, Bai D, Guo Y
MedComm 2023 Jun;4(3):e246
MedComm 2023 Jun;4(3):e246
Disruption of the ADAM17/NF-κB feedback loop in astrocytes ameliorates HIV-1 Tat-induced inflammatory response and neuronal death.
Qiu X, Wang J, Zhang W, Duan C, Chen T, Zhang D, Su J, Gao L
Journal of neurovirology 2023 Jun;29(3):283-296
Journal of neurovirology 2023 Jun;29(3):283-296
The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.
Niu J, Yan T, Guo W, Wang W, Ren T, Huang Y, Zhao Z, Yu Y, Chen C, Huang Q, Lou J, Guo L
Autophagy 2023 Jun;19(6):1693-1710
Autophagy 2023 Jun;19(6):1693-1710
Single cell RNA-seq resolution revealed CCR1(+)/SELL(+)/XAF(+) CD14 monocytes mediated vascular endothelial cell injuries in Kawasaki disease and COVID-19.
Liu X, Luo T, Fan Z, Li J, Zhang Y, Lu G, Lv M, Lin S, Cai Z, Zhang J, Zhou K, Guo J, Hua Y, Zhang Y, Li Y
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166707
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166707
Charged multivesicular body protein 2B ameliorates biliary injury in the liver from donation after cardiac death rats via autophagy with air-oxygenated normothermic machine perfusion.
Bai Y, Shi JH, Liu Q, Yang DJ, Yan ZP, Zhang JK, Tang HW, Guo WZ, Jin Y, Zhang SJ
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166686
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166686
Anti-oxidative-initiated cognitive impairment amelioration in Alzheimer's disease model rats through preventive transcutaneous electrical acupoint stimulation.
Weng H, Wang Q, Ye R, Bai Y, Yang H, Xu G, Wang Q
Integrative medicine research 2023 Jun;12(2):100946
Integrative medicine research 2023 Jun;12(2):100946
Role of ionizing radiation activated NRF2 in lung cancer radioresistance.
Xu Q, Zhang P, Han X, Ren H, Yu W, Hao W, Luo B, Khan MI, Chen N
International journal of biological macromolecules 2023 Jun 30;241:124476
International journal of biological macromolecules 2023 Jun 30;241:124476
SMYD3 drives the proliferation in gastric cancer cells via reducing EMP1 expression in an H4K20me3-dependent manner.
Zeng Y, Ma G, Cai F, Wang P, Liang H, Zhang R, Deng J, Liu Y
Cell death & disease 2023 Jun 29;14(6):386
Cell death & disease 2023 Jun 29;14(6):386
Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice.
Dong F, Yan W, Meng Q, Song X, Cheng B, Liu Y, Yao R
Behavioural brain research 2023 Jun 25;448:114444
Behavioural brain research 2023 Jun 25;448:114444
SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/β-catenin signaling pathway.
Wang D, Li Y, Xu C, Wang H, Huang X, Jin X, Ren S, Gao J, Tong J, Liu J, Zhou J, Shi L
iScience 2023 Jun 16;26(6):106917
iScience 2023 Jun 16;26(6):106917
Metformin synergistically enhances the antitumour activity of Lenvatinib in hepatocellular carcinoma by altering AKT-FOXO3 signalling pathway.
Cheng Y, Zhan P, Lu J, Lu Y, Luo C, Cen X, Wang F, Xie C, Yin Z
Liver international : official journal of the International Association for the Study of the Liver 2023 Jul;43(7):1577-1592
Liver international : official journal of the International Association for the Study of the Liver 2023 Jul;43(7):1577-1592
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Hom LM, Sun S, Campbell J, Liu P, Culbert S, Murphy IM, Schafer ZT
The Journal of biological chemistry 2023 Jul;299(7):104922
The Journal of biological chemistry 2023 Jul;299(7):104922
Decreased lamin A and B1 expression results in nuclear enlargement in serous ovarian carcinoma, whereas lamin A-expressing tumor cells metastasize to lymph nodes.
Ouchi M, Kobayashi S, Nishijima Y, Inoue N, Ikota H, Iwase A, Yokoo H, Saio M
Pathology, research and practice 2023 Jul;247:154560
Pathology, research and practice 2023 Jul;247:154560
Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway.
Wu B, Gan A, Wang R, Lin F, Yan T, Jia Y
Journal of chemical neuroanatomy 2023 Jul;130:102270
Journal of chemical neuroanatomy 2023 Jul;130:102270
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D, Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE, Upton JW, Li P, West AP
Cell 2023 Jul 6;186(14):3013-3032.e22
Cell 2023 Jul 6;186(14):3013-3032.e22
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Bai Y, Zhang L, Zheng B, Zhang X, Zhang H, Zhao A, Yu J, Yang Z, Wen J
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis.
Jia Q, Tan Y, Li Y, Wu Y, Wang J, Tang F
Cell death & disease 2023 Jul 21;14(7):459
Cell death & disease 2023 Jul 21;14(7):459
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W
Cancer letters 2023 Jul 10;566:216244
Cancer letters 2023 Jul 10;566:216244
NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury.
Liu J, Liu J, Meng C, Gu Q, Huang C, Liu F, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154529
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154529
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Yu X, Tong H, Chen J, Tang C, Wang S, Si Y, Wang S, Tang Z
Cell death & disease 2023 Jan 12;14(1):20
Cell death & disease 2023 Jan 12;14(1):20
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Xu M, Zhou Y, Fan S, Zhang M, Gao X
Amino acids 2023 Feb;55(2):243-252
Amino acids 2023 Feb;55(2):243-252
Absence of indoleamine 2,3‑dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice.
Ando T, Hoshi M, Tezuka H, Ito H, Nakamoto K, Yamamoto Y, Saito K
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage.
Wang Z, Li T, Du M, Zhang L, Xu L, Song H, Zhang J
Brain research bulletin 2023 Feb;193:117-130
Brain research bulletin 2023 Feb;193:117-130
Influence of RRM, RGG and Potential Phosphorylated Sites in Cold-Inducible Protein RBM3 on its Subcellular Localization and Neuroprotective Effects.
Wang L, Shao TC, Wang CY, Li JJ, Jian SQ, Wang D, Cheng BF
Frontiers in bioscience (Landmark edition) 2023 Feb 8;28(2):24
Frontiers in bioscience (Landmark edition) 2023 Feb 8;28(2):24
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Hom LM, Sun S, Campbell J, Liu P, Culbert S, Murphy IM, Schafer ZT
bioRxiv : the preprint server for biology 2023 Feb 22;
bioRxiv : the preprint server for biology 2023 Feb 22;
The Integrator complex regulates microRNA abundance through RISC loading.
Kirstein N, Dokaneheifard S, Cingaram PR, Valencia MG, Beckedorff F, Gomes Dos Santos H, Blumenthal E, Tayari MM, Gaidosh GS, Shiekhattar R
Science advances 2023 Feb 10;9(6):eadf0597
Science advances 2023 Feb 10;9(6):eadf0597
UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer.
Hong X, Ma N, Li D, Zhang M, Dong W, Huang J, Ci X, Zhang S
Cell death & disease 2023 Feb 10;14(2):100
Cell death & disease 2023 Feb 10;14(2):100
FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway.
Zhou Y, Chen Y, Shi Y, Wu L, Tan Y, Li T, Chen Y, Xia J, Hu R
The Journal of clinical investigation 2023 Feb 1;133(3)
The Journal of clinical investigation 2023 Feb 1;133(3)
The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells.
Zhou M, Boulos JC, Klauck SM, Efferth T
Cell biology and toxicology 2023 Dec;39(6):2971-2997
Cell biology and toxicology 2023 Dec;39(6):2971-2997
Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells.
Qi H, Lin G, Guo S, Guo X, Yu C, Zhang M, Gao X
Animal biotechnology 2023 Dec;34(8):4094-4104
Animal biotechnology 2023 Dec;34(8):4094-4104
Conessine inhibits enveloped viruses replication through up-regulating cholesterol level.
Zhou S, Li J, Ling X, Dong S, Zhang Z, Li M
Virus research 2023 Dec;338:199234
Virus research 2023 Dec;338:199234
Function of m(5)C RNA methyltransferase NOP2 in high-grade serous ovarian cancer.
Yang S, Zhou D, Zhang C, Xiang J, Xi X
Cancer biology & therapy 2023 Dec 31;24(1):2263921
Cancer biology & therapy 2023 Dec 31;24(1):2263921
A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.
Kuang H, Li Y, Wang Y, Shi M, Duan R, Xiao Q, She H, Liu Y, Liang Q, Teng Y, Zhou M, Liang D, Li Z, Wu L
Cell reports 2023 Dec 26;42(12):113445
Cell reports 2023 Dec 26;42(12):113445
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
Xu S, Wang N, Zuccaro MV, Gerhardt J, Baslan T, Koren A, Egli D
bioRxiv : the preprint server for biology 2023 Dec 26;
bioRxiv : the preprint server for biology 2023 Dec 26;
Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity.
Zhang X, Wu N, Huang H, Li S, Liu S, Zhang R, Huang Y, Lyu H, Xiao S, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J
Oncogene 2023 Aug;42(32):2439-2455
Oncogene 2023 Aug;42(32):2439-2455
HIV-1 subtype B Tat enhances NOTCH3 signaling in astrocytes to mediate oxidative stress, inflammatory response, and neuronal apoptosis.
Gao L, Sun W, Zhang D, Shang Y, Li L, Tao W, Zhang L, Liu H
Journal of neurovirology 2023 Aug;29(4):479-491
Journal of neurovirology 2023 Aug;29(4):479-491
Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin.
Deng DX, Li CY, Zheng ZY, Wen B, Liao LD, Zhang XJ, Li EM, Xu LY
Molecular & cellular proteomics : MCP 2023 Aug;22(8):100593
Molecular & cellular proteomics : MCP 2023 Aug;22(8):100593
Characterizing microglial senescence: Tau as a key player.
Karabag D, Scheiblich H, Griep A, Santarelli F, Schwartz S, Heneka MT, Ising C
Journal of neurochemistry 2023 Aug;166(3):517-533
Journal of neurochemistry 2023 Aug;166(3):517-533
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Wang H, Qiu Y, Zhang H, Chang N, Hu Y, Chen J, Hu R, Liao P, Li Z, Yang Y, Cen Q, Ding X, Li M, Xie X, Li Y
Cell death & disease 2023 Aug 4;14(8):498
Cell death & disease 2023 Aug 4;14(8):498
The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation.
Xie J, Du Y, Liu D, Wu J, Yang K, He X, Zhao J, Hong P, Liao K, Zhang H, Hong Y, Teijaro JR, Kang SG, Xiao C, Liu WH
Cell reports 2023 Aug 29;42(8):112968
Cell reports 2023 Aug 29;42(8):112968
HHEX suppresses advanced thyroid cancer by interacting with TLE3.
Xu Z, Feng Y, Yan Y, Jin H, Chen Y, Han Y, Huang S, Feng F, Fu H, Yin Y, Huang Y, Wang H, Cheng W
Molecular and cellular endocrinology 2023 Aug 20;574:111988
Molecular and cellular endocrinology 2023 Aug 20;574:111988
Carteolol triggers senescence via activation of β-arrestin-ERK-NOX4-ROS pathway in human corneal endothelial cells in vitro.
Jiang GJ, You XG, Fan TJ
Chemico-biological interactions 2023 Aug 1;380:110511
Chemico-biological interactions 2023 Aug 1;380:110511
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
Wen B, Deng DX, Liao LD, Zhang ZD, Zheng YQ, Dong K, Xu LY, Li EM
Biomedicines 2023 Apr 16;11(4)
Biomedicines 2023 Apr 16;11(4)
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats.
Liu W, Wang L, Liu C, Dai Z, Li T, Tang B
Biological & pharmaceutical bulletin 2022;45(9):1269-1275
Biological & pharmaceutical bulletin 2022;45(9):1269-1275
LPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis.
Li MZ, Wen XY, Liu XQ, Wang YQ, Yan L
Journal of inflammation research 2022;15:5707-5720
Journal of inflammation research 2022;15:5707-5720
Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway.
Huang D, Sun C, Chen M, Bai S, Zhao X, Wang W, Geng K, Huang W, Zhao T, Wu B, Zhang G, Wu D, Xu Y
Frontiers in pharmacology 2022;13:994878
Frontiers in pharmacology 2022;13:994878
Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice.
Ye Z, Ma J, Liu Y, Xu B, Dai X, Fu M, Tian T, Sui X, Mo F, Gao S, Zhao D, Zhang D
Frontiers in pharmacology 2022;13:950535
Frontiers in pharmacology 2022;13:950535
Allyl methyl trisulfide protected against LPS-induced acute lung injury in mice via inhibition of the NF-κB and MAPK pathways.
Wang S, Liu J, Dong J, Fan Z, Wang F, Wu P, Li X, Kou R, Chen F
Frontiers in pharmacology 2022;13:919898
Frontiers in pharmacology 2022;13:919898
Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B-Lamin B1 Interaction in Alcoholic Fatty Liver Disease.
Qi X, Zheng S, Ma M, Lian N, Wang H, Chen L, Song A, Lu C, Zheng S, Jin H
Frontiers in pharmacology 2022;13:912825
Frontiers in pharmacology 2022;13:912825
Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway.
Qu XQ, Chen QF, Shi QQ, Luo QQ, Zheng SY, Li YH, Bai LY, Gan S, Zhou XY
Frontiers in immunology 2022;13:901566
Frontiers in immunology 2022;13:901566
The Protective Effect of Evodiamine in Osteoarthritis: An In Vitro and In Vivo Study in Mice Model.
Xian S, Lin Z, Zhou C, Wu X
Frontiers in pharmacology 2022;13:899108
Frontiers in pharmacology 2022;13:899108
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Wu X, Zhao K, Fang X, Lu F, Cheng P, Song X, Zhang W, Yao C, Zhu J, Chen H
Frontiers in pharmacology 2022;13:845959
Frontiers in pharmacology 2022;13:845959
Hypoxic Cell-Derived Extracellular Vesicles Aggravate Rectal Injury Following Radiotherapy via MiR-122-5p.
Xu Y, Ge Y, Chen X, Zhang Y, Chen H, Liu D, Lu Y, Liu Y, Tu W
Frontiers in cell and developmental biology 2022;10:892575
Frontiers in cell and developmental biology 2022;10:892575
Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1.
Tian W, Yuan H, Qin S, Liu W, Zhang B, Gu L, Zhou J, Deng D
Molecular oncology 2022 Sep;16(17):3192-3209
Molecular oncology 2022 Sep;16(17):3192-3209
RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ.
Tang H, Li X, Jiang L, Liu Z, Chen L, Chen J, Deng M, Zhou F, Zheng X, Liu Z
Cancer science 2022 Sep;113(9):3071-3084
Cancer science 2022 Sep;113(9):3071-3084
Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe.
Luo S, He J, Huang S, Wang X, Su Y, Li Y, Chen Y, Yang G, Huang B, Guo S, Zhou L, Luo X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154106
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154106
Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte.
Wang SH, Chen YS, Lai KH, Lu CK, Chang HS, Wu HC, Yen FL, Chen LY, Lee JC, Yen CH
Antioxidants (Basel, Switzerland) 2022 Sep 5;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 5;11(9)
A Novel, Fully Spliced, Accessory Gene in Equine Lentivirus with Distinct Rev-Responsive Element.
Zhang X, Li J, Zhang M, Bai B, Ma W, Lin Y, Guo X, Wang XF, Wang X
Journal of virology 2022 Sep 28;96(18):e0098622
Journal of virology 2022 Sep 28;96(18):e0098622
Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.
Ye C, Li H, Li Y, Zhang Y, Liu G, Mi H, Li H, Xiao Q, Niu L, Yu X
iScience 2022 Sep 16;25(9):104872
iScience 2022 Sep 16;25(9):104872
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation.
Wang L, Li J, Wang Q, Ge MX, Ji J, Liu D, Wang Z, Cao Y, Zhang Y, Zhang ZR
Molecular cell 2022 Sep 15;82(18):3453-3467.e14
Molecular cell 2022 Sep 15;82(18):3453-3467.e14
GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis.
Wang M, Han X, Zha W, Wang X, Liu L, Li Z, Shi Y, Kan X, Wang G, Gao D, Zhang B
Molecular neurobiology 2022 Oct;59(10):6321-6340
Molecular neurobiology 2022 Oct;59(10):6321-6340
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression.
Guo Y, He J, Zhang H, Chen R, Li L, Liu X, Huang C, Qiang Z, Zhou Z, Wang Y, Huang J, Zhao X, Zheng J, Chen GQ, Yu J
Oncogene 2022 Oct;41(44):4877-4892
Oncogene 2022 Oct;41(44):4877-4892
Ultraviolet B irradiation induces senescence of human corneal endothelial cells in vitro by DNA damage response and oxidative stress.
Jiang GJ, You XG, Fan TJ
Journal of photochemistry and photobiology. B, Biology 2022 Oct;235:112568
Journal of photochemistry and photobiology. B, Biology 2022 Oct;235:112568
Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells.
Lyu R, Zhu X, Shen Y, Xiong L, Liu L, Liu H, Wu F, Argueta C, Tan L
Epigenetics 2022 Oct;17(10):1180-1194
Epigenetics 2022 Oct;17(10):1180-1194
Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage.
Arakawa N, Ushiki A, Abe M, Matsuyama S, Saito Y, Kashiwada T, Horimasu Y, Gemma A, Tatsumi K, Hattori N, Tsushima K, Miyashita K, Saito K, Nakamura R, Toyoda T, Ogawa K, Sato M, Takamatsu K, Mori K, Nishiya T, Izumi T, Ohno Y, Saito Y, Hanaoka M
Nature communications 2022 Oct 4;13(1):5854
Nature communications 2022 Oct 4;13(1):5854
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Wu B, Feng J, Guo J, Wang J, Xiu G, Xu J, Ning K, Ling B, Fu Q, Xu J
Stem cell research & therapy 2022 Oct 4;13(1):494
Stem cell research & therapy 2022 Oct 4;13(1):494
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350
Nature communications 2022 Oct 26;13(1):6350
Free and Bound Phenolics of Laird Lentil (Lens culinaris) Hulls and the Anti-inflammatory Activity of their Digestive Products via Crosstalk between NF-κB and Keap1-Nrf2 Signaling Pathways in HT-29 Cells.
Guo F, Peng L, Xiong H, Wang J, Tsao R, Peng X, Jiang L, Sun Y
Journal of agricultural and food chemistry 2022 Oct 19;70(41):13251-13263
Journal of agricultural and food chemistry 2022 Oct 19;70(41):13251-13263
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.
Shen H, Huang X, Zhao Y, Wu D, Xue K, Yao J, Wang Y, Tang N, Qiu Y
Nature communications 2022 Oct 13;13(1):6030
Nature communications 2022 Oct 13;13(1):6030
Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation.
Liu H, Liu Y, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(32):e2203995
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(32):e2203995
Exposure to Multiwall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis.
Tsunematsu T, Arakaki R, Sato M, Saito M, Otsuka K, Furukawa Y, Taquahashi Y, Kanno J, Ishimaru N
The American journal of pathology 2022 Nov;192(11):1559-1572
The American journal of pathology 2022 Nov;192(11):1559-1572
BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.
Liu C, Yu J, Liu B, Liu M, Song G, Zhu L, Peng B
BMC oral health 2022 Nov 24;22(1):536
BMC oral health 2022 Nov 24;22(1):536
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis.
Paul S, Kaplan MH, Khanna D, McCourt PM, Saha AK, Tsou PS, Anand M, Radecki A, Mourad M, Sawalha AH, Markovitz DM, Contreras-Galindo R
Nature communications 2022 Nov 18;13(1):7074
Nature communications 2022 Nov 18;13(1):7074
Major Vault Protein Prevents Atherosclerotic Plaque Destabilization by Suppressing Macrophage ASK1-JNK Signaling.
Liu Q, Pan J, Bao L, Xu C, Qi Y, Jiang B, Wang D, Zhu X, Li X, Zhang H, Bai H, Yang Q, Ma J, Wiemer EAC, Ben J, Chen Q
Arteriosclerosis, thrombosis, and vascular biology 2022 May;42(5):580-596
Arteriosclerosis, thrombosis, and vascular biology 2022 May;42(5):580-596
Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment.
Mei Z, Yang T, Liu Y, Gao Y, Hou Z, Zhuang Q, He D, Zhang X, Tan Q, Zhu X, Qin Y, Chen X, Xu C, Bian C, Wang X, Wang C, Wu D, Huang S, Li Z
Cell reports. Medicine 2022 May 17;3(5):100608
Cell reports. Medicine 2022 May 17;3(5):100608
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP(+)-induced oxidative stress.
Wu X, Ren Y, Wen Y, Lu S, Li H, Yu H, Li W, Zou F
Free radical biology & medicine 2022 Mar;181:82-97
Free radical biology & medicine 2022 Mar;181:82-97
Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner.
Zheng C, Yu X, Liang Y, Zhu Y, He Y, Liao L, Wang D, Yang Y, Yin X, Li A, He Q, Li B
Acta pharmaceutica Sinica. B 2022 Mar;12(3):1271-1287
Acta pharmaceutica Sinica. B 2022 Mar;12(3):1271-1287
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit.
Gao X, You J, Gong Y, Yuan M, Zhu H, Fang L, Zhu H, Ying M, He Q, Yang B, Cao J
Acta pharmaceutica Sinica. B 2022 Mar;12(3):1225-1239
Acta pharmaceutica Sinica. B 2022 Mar;12(3):1225-1239
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Qi H, Wang L, Zhang M, Wang Z, Gao X, Li M
The Journal of nutritional biochemistry 2022 Mar;101:108924
The Journal of nutritional biochemistry 2022 Mar;101:108924
Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.
Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H
Molecular cell 2022 Mar 17;82(6):1156-1168.e7
Molecular cell 2022 Mar 17;82(6):1156-1168.e7
Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition.
Wang F, Li S, Houerbi N, Chou TF
Cell chemical biology 2022 Mar 17;29(3):517-529.e5
Cell chemical biology 2022 Mar 17;29(3):517-529.e5
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
Yu X, Jiang N, Li J, Li X, He S
Tissue & cell 2022 Jun;76:101813
Tissue & cell 2022 Jun;76:101813
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
Han X, Zhang J, Zhou L, Wei J, Tu Y, Shi Q, Zhang Y, Ren J, Wang Y, Ying H, Liang G
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs.
Cao L, Luo Y, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y, You F
PLoS pathogens 2022 Jun;18(6):e1010599
PLoS pathogens 2022 Jun;18(6):e1010599
NPM1 promotes cell proliferation by targeting PRDX6 in colorectal cancer.
Wang D, Li Y, Liu Y, Cheng S, Liu F, Zuo R, Ding C, Shi S, Liu G
The international journal of biochemistry & cell biology 2022 Jun;147:106233
The international journal of biochemistry & cell biology 2022 Jun;147:106233
Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription.
Wen J, Zhao C, Chen J, Song S, Lin Z, Xie S, Qi H, Wang J, Su X
Cell insight 2022 Jun;1(3):100028
Cell insight 2022 Jun;1(3):100028
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
Zhao L, Zhao Y, Liu Q, Huang J, Lu Y, Ping J
Microbiology spectrum 2022 Jun 29;10(3):e0109822
Microbiology spectrum 2022 Jun 29;10(3):e0109822
TRIM62 silencing represses the proliferation and invasion and increases the chemosensitivity of hepatocellular carcinoma cells by affecting the NF-κB pathway.
Fan W, Liu X, Ren D
Toxicology and applied pharmacology 2022 Jun 15;445:116035
Toxicology and applied pharmacology 2022 Jun 15;445:116035
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation.
Arya SB, Chen S, Jordan-Javed F, Parent CA
Nature cell biology 2022 Jul;24(7):1019-1028
Nature cell biology 2022 Jul;24(7):1019-1028
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
Huo K, Ma KG, Guo QY, Duan P, Xu J
International immunopharmacology 2022 Jul;108:108718
International immunopharmacology 2022 Jul;108:108718
DNA Repair Factor Poly(ADP-Ribose) Polymerase 1 Is a Proviral Factor in Hepatitis B Virus Covalently Closed Circular DNA Formation.
Chen Y, Yao Y, Zhao K, Liu C, Yuan Y, Sun H, Huang D, Zheng Y, Zhou Y, Chen J, Wang Y, Wu C, Zhang B, Guan Y, Li F, Pei R, Chen X
Journal of virology 2022 Jul 13;96(13):e0058522
Journal of virology 2022 Jul 13;96(13):e0058522
TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1.
Yi L, Hu Y, Wu Z, Li Y, Kong M, Kang Z, Zuoyuan B, Yang Z
Cell death & disease 2022 Jul 11;13(7):592
Cell death & disease 2022 Jul 11;13(7):592
METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice.
Barajas JM, Lin CH, Sun HL, Alencastro F, Zhu AC, Aljuhani M, Navari L, Yilmaz SA, Yu L, Corps K, He C, Duncan AW, Ghoshal K
The American journal of pathology 2022 Jan;192(1):56-71
The American journal of pathology 2022 Jan;192(1):56-71
3-(3-Hydroxyphenyl)propionic acid, a microbial metabolite of quercetin, inhibits monocyte binding to endothelial cells via modulating E-selectin expression.
Feng J, Ge C, Li W, Li R
Fitoterapia 2022 Jan;156:105071
Fitoterapia 2022 Jan;156:105071
Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection.
Xu B, Yang R, Yang B, Li L, Chen J, Fu J, Qu X, Huo D, Tan C, Chen H, Peng Z, Wang X
Molecular brain 2022 Jan 3;15(1):4
Molecular brain 2022 Jan 3;15(1):4
Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes.
Chen H, Ma J, Liu J, Dou L, Shen T, Zuo H, Xu F, Zhao L, Tang W, Man Y, Ma Y, Li J, Huang X
FEBS letters 2022 Feb;596(4):510-525
FEBS letters 2022 Feb;596(4):510-525
The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.
Li M, Rao X, Cui Y, Zhang L, Li X, Wang B, Zheng Y, Teng L, Zhou T, Zhuo W
Oncogene 2022 Feb;41(6):770-781
Oncogene 2022 Feb;41(6):770-781
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
Bryant JD, Lei Y, VanPortfliet JJ, Winters AD, West AP
Current protocols 2022 Feb;2(2):e372
Current protocols 2022 Feb;2(2):e372
RETRACTED: TRIM21 deficiency confers protection from OGD/R-induced oxidative and inflammatory damage in cultured hippocampal neurons through regulation of the Keap1/Nrf2 pathway.
Fu Y, Gao J, Li Y, Yang X, Zhang Y
International immunopharmacology 2022 Feb;103:108414
International immunopharmacology 2022 Feb;103:108414
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction.
Li Q, Feng H, Wang H, Wang Y, Mou W, Xu G, Zhang P, Li R, Shi W, Wang Z, Fang Z, Ren L, Wang Y, Lin L, Hou X, Dai W, Li Z, Wei Z, Liu T, Wang J, Guo Y, Li P, Zhao X, Zhan X, Xiao X, Bai Z
EMBO reports 2022 Feb 3;23(2):e53499
EMBO reports 2022 Feb 3;23(2):e53499
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Ni L, Xiao J, Zhang D, Shao Z, Huang C, Wang S, Wu Y, Tian N, Sun L, Wu A, Zhou Y, Wang X, Zhang X
Cell death & disease 2022 Feb 10;13(2):140
Cell death & disease 2022 Feb 10;13(2):140
HIV-1 Tat drives the Fabp4/NF-κB feedback loop in microglia to mediate inflammatory response and neuronal apoptosis.
Zhou X, Zhou S, Tao J, Gao Y, Meng G, Cao D, Gao L
Journal of neurovirology 2022 Dec;28(4-6):483-496
Journal of neurovirology 2022 Dec;28(4-6):483-496
Blockade of CBX4-mediated β-catenin SUMOylation attenuates airway epithelial barrier dysfunction in asthma.
Liang S, Zhou Z, Zhou Z, Liang J, Lin W, Zhang C, Zhou C, Zhao H, Meng X, Zou F, Yu C, Cai S
International immunopharmacology 2022 Dec;113(Pt A):109333
International immunopharmacology 2022 Dec;113(Pt A):109333
Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3.
Bai Y, Liu J, Jiang X, Li X, Zhang B, Luo X
Cells 2022 Dec 3;11(23)
Cells 2022 Dec 3;11(23)
Onset of p53/NF-κB signaling crosstalk in human melanoma cells in response to anti-cancer theabrownin.
Li T, Yan B, Xiao X, Zhou L, Zhang J, Yuan Q, Shan L, Wu H, Efferth T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22426
METTL3 preferentially enhances non-m(6)A translation of epigenetic factors and promotes tumourigenesis.
Wei X, Huo Y, Pi J, Gao Y, Rao S, He M, Wei Q, Song P, Chen Y, Lu D, Song W, Liang J, Xu L, Wang H, Hong G, Guo Y, Si Y, Xu J, Wang X, Ma Y, Yu S, Zou D, Jin J, Wang F, Yu J
Nature cell biology 2022 Aug;24(8):1278-1290
Nature cell biology 2022 Aug;24(8):1278-1290
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export.
Hall R, Guedán A, Yap MW, Young GR, Harvey R, Stoye JP, Bishop KN
PLoS pathogens 2022 Aug;18(8):e1010349
PLoS pathogens 2022 Aug;18(8):e1010349
Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism.
Li T, Zhou L, Fan M, Chen Z, Yan L, Lu H, Jia M, Wu H, Shan L
Stem cell reviews and reports 2022 Aug;18(6):2088-2103
Stem cell reviews and reports 2022 Aug;18(6):2088-2103
Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway.
Jiang Y, Li JJ, Mu YW, Jiang HY, Wei ZX, Xiao ZY, Zhao JJ, Chen XH
Neurotoxicity research 2022 Apr;40(2):365-372
Neurotoxicity research 2022 Apr;40(2):365-372
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Antioxidant Activity of Acanthopanax senticosus Flavonoids in H(2)O(2)-Induced RAW 264.7 Cells and DSS-Induced Colitis in Mice.
Su J, Zhang X, Kan Q, Chu X
Molecules (Basel, Switzerland) 2022 Apr 30;27(9)
Molecules (Basel, Switzerland) 2022 Apr 30;27(9)
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
Yang Y, Liu S, He C, Lv T, Zeng L, Zhang F, Chen H, Zhao RC
Cell & bioscience 2022 Apr 21;12(1):45
Cell & bioscience 2022 Apr 21;12(1):45
Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.
Zhou Z, Li H, Bai S, Xu Z, Jiao Y
Biochemical and biophysical research communications 2022 Apr 16;600:87-93
Biochemical and biophysical research communications 2022 Apr 16;600:87-93
PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway.
Li H, Wang C, Lan L, Wu W, Evans I, Ruiz EJ, Yan L, Zhou Z, Oliveira JM, Reis RL, Hu Z, Chen W, Behrens A, He Y, Zhang C
Frontiers in cell and developmental biology 2021;9:719192
Frontiers in cell and developmental biology 2021;9:719192
Arid4b alters cell cycle and cell death dynamics during mouse embryonic stem cell differentiation.
GÜven G, Terzİ ÇİzmecİoĞlu N
Turkish journal of biology = Turk biyoloji dergisi 2021;45(1):56-64
Turkish journal of biology = Turk biyoloji dergisi 2021;45(1):56-64
Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1.
Hu X, Li M, Zhang C, Pang S
International journal of endocrinology 2021;2021:8867218
International journal of endocrinology 2021;2021:8867218
Protective Effect of Jiang Tang Xiao Ke Granules against Skeletal Muscle IR via Activation of the AMPK/SIRT1/PGC-1α Signaling Pathway.
Bai Y, Zuo J, Fang X, Ma R, Tian T, Mo F, Mu Q, Zhang Y, Yu N, Bao X, Zhang D, Gao S, Zhao D
Oxidative medicine and cellular longevity 2021;2021:5566053
Oxidative medicine and cellular longevity 2021;2021:5566053
GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy.
Guo W, Li W, Su Y, Liu S, Kan X, Ran X, Cao Y, Fu S, Liu J
International journal of biological sciences 2021;17(15):4271-4284
International journal of biological sciences 2021;17(15):4271-4284
Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.
Wang CM, Li HF, Wang XK, Li WG, Su Q, Xiao X, Hao TF, Chen W, Zhang YW, Zhang HY, Wu W, Hu ZR, Zhao GY, Huo MY, He YL, Zhang CH
International journal of biological sciences 2021;17(11):2811-2825
International journal of biological sciences 2021;17(11):2811-2825
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Pang Z, Jiang Z, Zhu R, Song C, Tang H, Cao L, Guo C
Drug design, development and therapy 2021;15:3735-3747
Drug design, development and therapy 2021;15:3735-3747
Transcription Coactivator BCL3 Acts as a Potential Regulator of Lipid Metabolism Through the Effects on Inflammation.
Zhang S, Gao J, Liu S, Yu L, Zhang W, Liang Y, Wang H
Journal of inflammation research 2021;14:4915-4926
Journal of inflammation research 2021;14:4915-4926
Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.
Jia Y, Li J, Liu P, Si M, Jin Y, Wang H, Ma D, Chu L
Frontiers in pharmacology 2021;12:758670
Frontiers in pharmacology 2021;12:758670
PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress.
Yin L, Li H, Liu Z, Wu W, Cai J, Tang C, Dong Z
Frontiers in immunology 2021;12:690697
Frontiers in immunology 2021;12:690697
Angelica Polysaccharide Antagonizes 5-FU-Induced Oxidative Stress Injury to Reduce Apoptosis in the Liver Through Nrf2 Pathway.
Zeng D, Wang Y, Chen Y, Li D, Li G, Xiao H, Hou J, Wang Z, Hu L, Wang L, Li J
Frontiers in oncology 2021;11:720620
Frontiers in oncology 2021;11:720620
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration.
Guedán A, Donaldson CD, Caroe ER, Cosnefroy O, Taylor IA, Bishop KN
PLoS pathogens 2021 Sep;17(9):e1009484
PLoS pathogens 2021 Sep;17(9):e1009484
MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling.
Wang Y, Zhang J, Li YJ, Yu NN, Liu WT, Liang JZ, Xu WW, Sun ZH, Li B, He QY
Journal of experimental & clinical cancer research : CR 2021 Sep 24;40(1):301
Journal of experimental & clinical cancer research : CR 2021 Sep 24;40(1):301
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q
Molecular neurodegeneration 2021 Sep 22;16(1):66
Molecular neurodegeneration 2021 Sep 22;16(1):66
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.
Liu C, Ma L, Wang Y, Zhao J, Chen P, Chen X, Wang Y, Hu Y, Liu Y, Jia X, Yang Z, Yin X, Wu J, Wu S, Zheng H, Ma X, Sun X, He Y, Lin L, Fu Y, Liao K, Zhou X, Jiang S, Fu G, Tang J, Han W, Chen XL, Fan W, Hong Y, Han J, Huang X, Li BA, Xiao N, Xiao C, Fu G, Liu WH
Science advances 2021 Oct 8;7(41):eabg6262
Science advances 2021 Oct 8;7(41):eabg6262
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Han Y, Xiong S, Zhao H, Yang S, Yang M, Zhu X, Jiang N, Xiong X, Gao P, Wei L, Xiao Y, Sun L
Cell death & disease 2021 Oct 30;12(11):1031
Cell death & disease 2021 Oct 30;12(11):1031
The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation.
Li Y, Zhang N, Ma C, Xu W, Jin G, Zheng Y, Zhang L, Liu B, Gao C, Liu S
Cell death & disease 2021 Oct 26;12(11):1001
Cell death & disease 2021 Oct 26;12(11):1001
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
Wang F, Zhang Y, Yu X, Teng XL, Ding R, Hu Z, Wang A, Wang Z, Ye Y, Zou Q
The Journal of clinical investigation 2021 Oct 1;131(19)
The Journal of clinical investigation 2021 Oct 1;131(19)
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation.
Lu ZN, Niu WX, Zhang N, Ge MX, Bao YY, Ren Y, Guo XL, He HW
Acta pharmacologica Sinica 2021 Nov;42(11):1808-1820
Acta pharmacologica Sinica 2021 Nov;42(11):1808-1820
Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization.
Jin J, Tong X, Zhang YL, Yang W, Ma Y, Ren P, Zhou F, Zhang S
Journal of assisted reproduction and genetics 2021 Nov;38(11):2861-2869
Journal of assisted reproduction and genetics 2021 Nov;38(11):2861-2869
ATRX proximal protein associations boast roles beyond histone deposition.
Scott WA, Dhanji EZ, Dyakov BJA, Dreseris ES, Asa JS, Grange LJ, Mirceta M, Pearson CE, Stewart GS, Gingras AC, Campos EI
PLoS genetics 2021 Nov;17(11):e1009909
PLoS genetics 2021 Nov;17(11):e1009909
DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma.
Zhu B, Chen JJ, Feng Y, Yang JL, Huang H, Chung WY, Hu YL, Xue WJ
Journal of experimental & clinical cancer research : CR 2021 Nov 8;40(1):352
Journal of experimental & clinical cancer research : CR 2021 Nov 8;40(1):352
KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.
Pang L, Tian H, Gao X, Wang W, Wang X, Zhang Z
Bioscience reports 2021 Nov 26;41(11)
Bioscience reports 2021 Nov 26;41(11)
Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation.
Wei M, Huang J, Li GW, Jiang B, Cheng H, Liu X, Jiang X, Zhang X, Yang L, Bao L, Wang B
Cell reports 2021 May 4;35(5):109053
Cell reports 2021 May 4;35(5):109053
TET2 Inhibits PD-L1 Gene Expression in Breast Cancer Cells through Histone Deacetylation.
Shen Y, Liu L, Wang M, Xu B, Lyu R, Shi YG, Tan L
Cancers 2021 May 4;13(9)
Cancers 2021 May 4;13(9)
The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Chen Y, Wang Y, Chen J, Zuo W, Fan Y, Huang S, Liu Y, Chen G, Li Q, Li J, Wu J, Bian Q, Huang C, Lei M
Nature communications 2021 May 26;12(1):3176
Nature communications 2021 May 26;12(1):3176
Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury.
Wang Y, Xu G, Wang Z, Li R, Zhan X, Liu H, Qin Q, Li W, Wang X, Zhang M, Tang J, Bai Z, Xiao X
International immunopharmacology 2021 Mar;92:107352
International immunopharmacology 2021 Mar;92:107352
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
Luo X, Bai Y, He S, Sun S, Jiang X, Yang Z, Lu D, Wei P, Liang Y, Peng C, Wang Y, Sheng R, Han S, Li X, Zhang B
Cell proliferation 2021 Mar;54(3):e12991
Cell proliferation 2021 Mar;54(3):e12991
miR-142-3p reduces the viability of human cervical cancer cells by negatively regulating the cytoplasmic localization of HMGB1.
Dong H, Song J
Experimental and therapeutic medicine 2021 Mar;21(3):212
Experimental and therapeutic medicine 2021 Mar;21(3):212
Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway.
Yang S, Jiang W, Yang W, Yang C, Yang X, Chen K, Hu Y, Shen G, Lu L, Cheng F, Zhang F, Rao J, Wang X
Molecular therapy. Nucleic acids 2021 Mar 5;23:944-958
Molecular therapy. Nucleic acids 2021 Mar 5;23:944-958
PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells.
Kang JW, Zhan Z, Ji G, Sang Y, Zhou D, Li Y, Feng H, Cheng T
Signal transduction and targeted therapy 2021 Mar 31;6(1):129
Signal transduction and targeted therapy 2021 Mar 31;6(1):129
ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.
Cao LJ, Zhang YJ, Dong SQ, Li XZ, Tong XT, Chen D, Wu ZY, Zheng XH, Xue WQ, Jia WH, Zhang JB
Journal of experimental & clinical cancer research : CR 2021 Mar 23;40(1):109
Journal of experimental & clinical cancer research : CR 2021 Mar 23;40(1):109
Inhibitory activity of flavonoids from Ephedrae Herba on hypoxia signaling in PANC-1 cells and the evaluation of their mechanisms.
Yahagi H, Yahagi T, Matsumura M, Igarashi K, Yokoyama N, Matsuzaki K
Journal of natural medicines 2021 Jun;75(3):612-622
Journal of natural medicines 2021 Jun;75(3):612-622
Molecular Mechanism of Platelet-Derived Growth Factor (PDGF)-BB-Mediated Protection Against MPP(+) Toxicity in SH-SY5Y Cells.
Chen H, Teng Y, Liu Z, Geng F, Chen X, Jiang H, Yang J, Zheng M, Wang Z, Yang L
Journal of molecular neuroscience : MN 2021 Jun;71(6):1131-1143
Journal of molecular neuroscience : MN 2021 Jun;71(6):1131-1143
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
Li SS, Chen DM, Chen LB, Wei H, Wang JL, Xiao J, Huang YH, Lian YF
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.
Li W, Li Y, Guan Y, Du Y, Zhao M, Chen X, Zhu F, Guo C, Jia Y, Li Y, Wang X, Wang X, Shi Y, Wang Q, Li Y, Zhang L
Autophagy 2021 Jun;17(6):1410-1425
Autophagy 2021 Jun;17(6):1410-1425
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Li X, Wang X, Miao L, Guo Y, Yuan R, Tian H
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
Pan X, Zhao J, Zhou Z, Chen J, Yang Z, Wu Y, Bai M, Jiao Y, Yang Y, Hu X, Cheng T, Lu Q, Wang B, Li CL, Lu YJ, Diao L, Zhong YQ, Pan J, Zhu J, Xiao HS, Qiu ZL, Li J, Wang Z, Hui J, Bao L, Zhang X
eLife 2021 Jun 29;10
eLife 2021 Jun 29;10
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, Yang W, Mai Y, Liu R, Chen M, Dai C, Yang H, Lu J, Li H, Guan G, Huang M, Liu P, Li Z
Cell death & disease 2021 Jul 26;12(8):738
Cell death & disease 2021 Jul 26;12(8):738
Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP.
Chen Y, Hao Q, Wang S, Cao M, Huang Y, Weng X, Wang J, Zhang Z, He X, Lu H, Zhou X
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Spermidine at supraphysiological doses induces oxidative stress and granulosa cell apoptosis in mouse ovaries.
Jiang D, Jiang Y, Long S, Chen Z, Li Y, Mo G, Bai L, Hao X, Yan Y, Li L, Han C, Hu S, Zhao H, Kang B
Theriogenology 2021 Jul 1;168:25-32
Theriogenology 2021 Jul 1;168:25-32
Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats.
Liu H, Guo Y, Zhu R, Wang L, Chen B, Tian Y, Li R, Ma R, Jia Q, Zhang H, Xia B, Li Y, Wang X, Zhu X, Zhang R, Brӧmme D, Gao S, Zhang D, Pei X
Phytotherapy research : PTR 2021 Jan;35(1):424-441
Phytotherapy research : PTR 2021 Jan;35(1):424-441
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
Li S, Kuang M, Chen L, Li Y, Liu S, Du H, Cao L, You F
Cell reports 2021 Jan 19;34(3):108631
Cell reports 2021 Jan 19;34(3):108631
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer.
Liu Y, Huang Z, Wei Y, Zhang M, Li X, Yang S, Wang H
Cancer immunology, immunotherapy : CII 2021 Feb;70(2):275-287
Cancer immunology, immunotherapy : CII 2021 Feb;70(2):275-287
Regulatory role of DEPTOR‑mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma.
Wang J, Chen J, Qiu D, Zeng Z
International journal of molecular medicine 2021 Feb;47(2):643-658
International journal of molecular medicine 2021 Feb;47(2):643-658
Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair.
Murray-Nerger LA, Justice JL, Rekapalli P, Hutton JE, Cristea IM
Nucleic acids research 2021 Feb 26;49(4):2044-2064
Nucleic acids research 2021 Feb 26;49(4):2044-2064
Abnormal nitration and S-sulfhydration modification of Sp1-CSE-H(2)S pathway trap the progress of hyperhomocysteinemia into a vicious cycle.
Luo C, Ji D, Li Y, Cao Y, Zhang S, Yan W, Xue K, Chai J, Wu Y, Liu H, Wang W
Free radical biology & medicine 2021 Feb 20;164:20-33
Free radical biology & medicine 2021 Feb 20;164:20-33
Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Sarkar A, Stellrecht CM, Vangapandu HV, Ayres M, Kaipparettu BA, Park JH, Balakrishnan K, Burks JK, Pandita TK, Hittelman WN, Neelapu SS, Gandhi V
Haematologica 2021 Feb 1;106(2):495-512
Haematologica 2021 Feb 1;106(2):495-512
Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux.
Lu J, Lu J, Bu X, Li Y, Ge G, Guan S
Journal of food science 2021 Dec;86(12):5503-5515
Journal of food science 2021 Dec;86(12):5503-5515
Increased long noncoding RNA LINK-A contributes to rheumatoid synovial inflammation and aggression.
Wang J, Shen C, Li R, Wang C, Xiao Y, Kuang Y, Lao M, Xu S, Shi M, Cai X, Liang L, Xu H
JCI insight 2021 Dec 8;6(23)
JCI insight 2021 Dec 8;6(23)
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Zou Q, Yang L, Shi R, Qi Y, Zhang X, Qi H
iScience 2021 Dec 17;24(12):103396
iScience 2021 Dec 17;24(12):103396
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Wang Y, Jin R, Chen J, Cao J, Xiao J, Li X, Sun C
Food chemistry 2021 Dec 15;365:130470
Food chemistry 2021 Dec 15;365:130470
BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate.
Nagy A, Pethő D, Gesztelyi R, Juhász B, Balla G, Szilvássy Z, Balla J, Gáll T
International journal of molecular sciences 2021 Aug 26;22(17)
International journal of molecular sciences 2021 Aug 26;22(17)
The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.
Zhang Y, Liu C, Wu B, Li L, Li W, Yuan L
Nature communications 2021 Aug 13;12(1):4926
Nature communications 2021 Aug 13;12(1):4926
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Zhang Y, Huang W, Zheng Z, Wang W, Yuan Y, Hong Q, Lin J, Li X, Meng Y
Free radical biology & medicine 2021 Apr;166:116-127
Free radical biology & medicine 2021 Apr;166:116-127
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation.
Xiao J, Xiong Y, Yang LT, Wang JQ, Zhou ZM, Dong LW, Shi XJ, Zhao X, Luo J, Song BL
Protein & cell 2021 Apr;12(4):279-296
Protein & cell 2021 Apr;12(4):279-296
Interaction of NEP with G Protein Pathway Suppressor 2 Facilitates Influenza A Virus Replication by Weakening the Inhibition of GPS2 to RNA Synthesis and Ribonucleoprotein Assembly.
Gong W, He X, Huang K, Zhang Y, Li C, Yang Y, Zou Z, Jin M
Journal of virology 2021 Apr 26;95(10)
Journal of virology 2021 Apr 26;95(10)
Discovering the Mechanisms of Wikstroelide E as a Potential HIV-Latency-Reversing Agent by Transcriptome Profiling.
Li SF, Liang X, Wu XK, Gao X, Zhang LW
Journal of natural products 2021 Apr 23;84(4):1022-1033
Journal of natural products 2021 Apr 23;84(4):1022-1033
Seco-type β-Apocarotenoid Generated by β-Carotene Oxidation Exerts Anti-inflammatory Effects against Activated Macrophages.
Takatani N, Beppu F, Yamano Y, Maoka T, Hosokawa M
Journal of oleo science 2021 Apr 2;70(4):549-558
Journal of oleo science 2021 Apr 2;70(4):549-558
Deletion of LBR N-terminal domains recapitulates Pelger-Huet anomaly phenotypes in mouse without disrupting X chromosome inactivation.
Young AN, Perlas E, Ruiz-Blanes N, Hierholzer A, Pomella N, Martin-Martin B, Liverziani A, Jachowicz JW, Giannakouros T, Cerase A
Communications biology 2021 Apr 12;4(1):478
Communications biology 2021 Apr 12;4(1):478
Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9(+) cells to prevent the development of liver cancer in a mouse model.
Chen M, Lu C, Lu H, Zhang J, Qin D, Liu S, Li X, Zhang L
Stem cell research & therapy 2021 Apr 12;12(1):232
Stem cell research & therapy 2021 Apr 12;12(1):232
Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator.
Chen YS, Chang HS, Hsiao HH, Chen YF, Kuo YP, Yen FL, Yen CH
Antioxidants (Basel, Switzerland) 2021 Apr 1;10(4)
Antioxidants (Basel, Switzerland) 2021 Apr 1;10(4)
Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.
Zhang T, Li H, Wang K, Xu B, Chen ZN, Bian H
Frontiers in cell and developmental biology 2020;8:784
Frontiers in cell and developmental biology 2020;8:784
β-Actin facilitates etoposide-induced p53 nuclear import.
Qi W, Li J, Pei X, Ke Y, Bu Q, Ni X
Journal of biosciences 2020;45
Journal of biosciences 2020;45
Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway.
Chen W, Yuan C, Lu Y, Zhu Q, Ma X, Xiao W, Gong W, Huang W, Xia Q, Lu G, Li W
Oxidative medicine and cellular longevity 2020;2020:5390482
Oxidative medicine and cellular longevity 2020;2020:5390482
Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway.
Li Y, Liu T, Li Y, Han D, Hong J, Yang N, He J, Peng R, Mi X, Kuang C, Zhou Y, Han Y, Shi C, Li Z, Guo X
Oxidative medicine and cellular longevity 2020;2020:4751349
Oxidative medicine and cellular longevity 2020;2020:4751349
Metformin Ameliorates Gestational Diabetes Mellitus-Induced Endothelial Dysfunction via Downregulation of p65 and Upregulation of Nrf2.
Sun CC, Lai YN, Wang WH, Xu XM, Li XQ, Wang H, Zheng JY, Zheng JQ
Frontiers in pharmacology 2020;11:575390
Frontiers in pharmacology 2020;11:575390
SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β-catenin signaling pathway.
Wang J, Ling R, Zhou Y, Gao X, Yang Y, Mao C, Chen D
Oncology letters 2020 Sep;20(3):2855-2869
Oncology letters 2020 Sep;20(3):2855-2869
Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas.
Nakashima C, Kirita T, Yamamoto K, Mori S, Luo Y, Sasaki T, Fujii K, Ohmori H, Kawahara I, Mori T, Goto K, Kishi S, Fujiwara-Tani R, Kuniyasu H
International journal of molecular sciences 2020 Sep 28;21(19)
International journal of molecular sciences 2020 Sep 28;21(19)
Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
Zheng J, Tian J, Wang S, Hu P, Wu Q, Shan X, Zhao P, Zhang C, Guo W, Xu M, Chen H, Lu R
European journal of pharmacology 2020 Sep 15;883:173386
European journal of pharmacology 2020 Sep 15;883:173386
Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells.
Miyamoto M, Sawada K, Nakamura K, Yoshimura A, Ishida K, Kobayashi M, Shimizu A, Yamamoto M, Kodama M, Hashimoto K, Kimura T
Scientific reports 2020 Oct 7;10(1):16755
Scientific reports 2020 Oct 7;10(1):16755
Evaluation of cancer-derived myocardial impairments using a mouse model.
Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
Oncotarget 2020 Oct 13;11(41):3712-3722
Oncotarget 2020 Oct 13;11(41):3712-3722
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Dai W, Xu L, Yu X, Zhang G, Guo H, Liu H, Song G, Weng S, Dong L, Zhu J, Liu T, Guo C, Shen X
Journal of hepatology 2020 May;72(5):909-923
Journal of hepatology 2020 May;72(5):909-923
Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice.
Hoshi M, Osawa Y, Nakamoto K, Morita N, Yamamoto Y, Ando T, Tashita C, Nabeshima T, Saito K
Toxicology 2020 May 30;438:152458
Toxicology 2020 May 30;438:152458
Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer.
Rai R, Gong Essel K, Mangiaracina Benbrook D, Garland J, Daniel Zhao Y, Chandra V
Cancers 2020 May 18;12(5)
Cancers 2020 May 18;12(5)
Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis.
Zhao M, Shen L, Ouyang Z, Li M, Deng G, Yang C, Zheng W, Kong L, Wu X, Wu X, Guo W, Yin Y, Xu Q, Sun Y
Journal of molecular cell biology 2020 May 18;12(4):277-290
Journal of molecular cell biology 2020 May 18;12(4):277-290
Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity.
Xu J, Chen Y, Yang R, Zhou T, Ke W, Si Y, Yang S, Zhang T, Liu X, Zhang L, Xiang K, Guo Y, Liu Y
Archives of biochemistry and biophysics 2020 May 15;684:108314
Archives of biochemistry and biophysics 2020 May 15;684:108314
Arsenic trioxide induces gasdermin E mediated pyroptosis in astroglioma cells.
Wang J, Zhan L, Cai Z, Liu X, Wang J, Zhong H, Huang X, Lai Q, Tan Q, Xiu Y, Yang D, Min X
Translational cancer research 2020 Mar;9(3):1926-1930
Translational cancer research 2020 Mar;9(3):1926-1930
23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9.
Li HH, Li J, Zhang XJ, Li JM, Xi C, Wang WQ, Lu YL, Xuan LJ
Acta pharmacologica Sinica 2020 Mar;41(3):327-335
Acta pharmacologica Sinica 2020 Mar;41(3):327-335
Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Schwartz S, Santarelli F, Gieselmann V, Klockgether T, Brosseron F, Heneka MT
Journal of neurochemistry 2020 Mar;152(6):710-726
Journal of neurochemistry 2020 Mar;152(6):710-726
Polymorphisms in Human APOBEC3H Differentially Regulate Ubiquitination and Antiviral Activity.
Chesarino NM, Emerman M
Viruses 2020 Mar 30;12(4)
Viruses 2020 Mar 30;12(4)
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Liu J, Tan Y, Yang B, Wu Y, Fan B, Zhu S, Song E, Song Y
Environment international 2020 Jun;139:105701
Environment international 2020 Jun;139:105701
Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging.
Sasik MUT, Eravsar ETK, Kinali M, Ergul AA, Adams MM
Neuroscience 2020 Jun 1;436:46-73
Neuroscience 2020 Jun 1;436:46-73
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma.
Wang SJ, Chao D, Wei W, Nan G, Li JY, Liu FL, Li L, Jiang JL, Cui HY, Chen ZN
Journal of experimental & clinical cancer research : CR 2020 Jul 29;39(1):145
Journal of experimental & clinical cancer research : CR 2020 Jul 29;39(1):145
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Dong Y, Xing Y, Sun J, Sun W, Xu Y, Quan C
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABA(A) receptors.
Teoh J, Subramanian N, Pero ME, Bartolini F, Amador A, Kanber A, Williams D, Petri S, Yang M, Allen AS, Beal J, Haut SR, Frankel WN
Neurobiology of disease 2020 Feb;134:104632
Neurobiology of disease 2020 Feb;134:104632
Oncogenic role of TYRO3 receptor tyrosine kinase in the progression of pancreatic cancer.
Morimoto M, Horikoshi Y, Nakaso K, Kurashiki T, Kitagawa Y, Hanaki T, Sakamoto T, Honjo S, Umekita Y, Fujiwara Y, Matsura T
Cancer letters 2020 Feb 1;470:149-160
Cancer letters 2020 Feb 1;470:149-160
Ribosome 18S m(6)A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.
Rong B, Zhang Q, Wan J, Xing S, Dai R, Li Y, Cai J, Xie J, Song Y, Chen J, Zhang L, Yan G, Zhang W, Gao H, Han JJ, Qu Q, Ma H, Tian Y, Lan F
Cell reports 2020 Dec 22;33(12):108544
Cell reports 2020 Dec 22;33(12):108544
Tet2 regulates Barx2 expression in undifferentiated and early differentiated mouse embryonic stem cells.
Qiao Z, Zhang S, Hu T, Lan F, Yu D, Ge G, Li C, Fang S, Chen Q
Biochemical and biophysical research communications 2020 Dec 17;533(4):1212-1218
Biochemical and biophysical research communications 2020 Dec 17;533(4):1212-1218
The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43.
Wong P, Ho WY, Yen YC, Sanford E, Ling SC
Neurobiology of aging 2020 Aug;92:43-60
Neurobiology of aging 2020 Aug;92:43-60
BPTES inhibits anthrax lethal toxin-induced inflammatory response.
Wang J, Yang D, Shen X, Wang J, Liu X, Lin J, Zhong J, Zhao Y, Qi Z
International immunopharmacology 2020 Aug;85:106664
International immunopharmacology 2020 Aug;85:106664
Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly.
Li Y, Li M, Weigel B, Mall M, Werth VP, Liu ML
EMBO reports 2020 Aug 5;21(8):e48779
EMBO reports 2020 Aug 5;21(8):e48779
Effects of peptidoglycan on the development of steatohepatitis.
Jin M, Lai Y, Zhao P, Shen Q, Su W, Yin Y, Zhang W
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Apr;1865(4):158595
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Apr;1865(4):158595
OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3.
Zhang Z, Wang D, Wang P, Zhao Y, You F
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 1;204(7):1904-1918
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 1;204(7):1904-1918
CACYBP Enhances Cytoplasmic Retention of P27(Kip1) to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.
Lian YF, Huang YL, Zhang YJ, Chen DM, Wang JL, Wei H, Bi YH, Jiang ZW, Li P, Chen MS, Huang YH
Theranostics 2019;9(26):8392-8408
Theranostics 2019;9(26):8392-8408
Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage.
Ye J, Luo D, Xu X, Sun M, Su X, Tian Z, Zhang M, Yu C, Guan Q
Oxidative medicine and cellular longevity 2019;2019:9151067
Oxidative medicine and cellular longevity 2019;2019:9151067
Deficiency of emerin contributes differently to the pathogenesis of skeletal and cardiac muscles in LmnaH222P/H222P mutant mice.
Wada E, Kato M, Yamashita K, Kokuba H, Liang WC, Bonne G, Hayashi YK
PloS one 2019;14(8):e0221512
PloS one 2019;14(8):e0221512
Nigericin Promotes NLRP3-Independent Bacterial Killing in Macrophages.
Armstrong H, Bording-Jorgensen M, Chan R, Wine E
Frontiers in immunology 2019;10:2296
Frontiers in immunology 2019;10:2296
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P(2) and extended synaptotagmins.
Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X, Song BL
Science China. Life sciences 2019 Sep;62(9):1117-1135
Science China. Life sciences 2019 Sep;62(9):1117-1135
Probiotic effect on Helicobacter pylori attachment and inhibition of inflammation in human gastric epithelial cells.
Song H, Zhou L, Liu D, Ge L, Li Y
Experimental and therapeutic medicine 2019 Sep;18(3):1551-1562
Experimental and therapeutic medicine 2019 Sep;18(3):1551-1562
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
Sang Y, Li Y, Zhang Y, Alvarez AA, Yu B, Zhang W, Hu B, Cheng SY, Feng H
Nature communications 2019 Sep 5;10(1):4013
Nature communications 2019 Sep 5;10(1):4013
ACLY facilitates colon cancer cell metastasis by CTNNB1.
Wen J, Min X, Shen M, Hua Q, Han Y, Zhao L, Liu L, Huang G, Liu J, Zhao X
Journal of experimental & clinical cancer research : CR 2019 Sep 12;38(1):401
Journal of experimental & clinical cancer research : CR 2019 Sep 12;38(1):401
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.
Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F
Cell host & microbe 2019 Sep 11;26(3):369-384.e8
Cell host & microbe 2019 Sep 11;26(3):369-384.e8
Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance.
Huang Y, Yi X, Kang C, Wu C
Cells 2019 Oct 16;8(10)
Cells 2019 Oct 16;8(10)
USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.
Ting X, Xia L, Yang J, He L, Si W, Shang Y, Sun L
Nucleic acids research 2019 Oct 10;47(18):9721-9740
Nucleic acids research 2019 Oct 10;47(18):9721-9740
The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING.
Wang P, Li S, Zhao Y, Zhang B, Li Y, Liu S, Du H, Cao L, Ou M, Ye X, Li P, Gao X, Wang P, Jing C, Shao F, Yang G, You F
The Journal of biological chemistry 2019 Nov 8;294(45):16494-16508
The Journal of biological chemistry 2019 Nov 8;294(45):16494-16508
The phosphorylation of Tudor-SN mediated by JNK is involved in the regulation of milk protein synthesis induced by prolactin in BMECs.
Zhang S, Qi H, Wen XP, Li P, Gao XJ, Ao JX
Journal of cellular physiology 2019 May;234(5):6077-6090
Journal of cellular physiology 2019 May;234(5):6077-6090
Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
Yang C, Lu M, Chen W, He Z, Hou X, Feng M, Zhang H, Bo T, Zhou X, Yu Y, Zhang H, Zhao M, Wang L, Yu C, Gao L, Jiang W, Zhang Q, Zhao J
The Journal of experimental medicine 2019 May 6;216(5):1182-1198
The Journal of experimental medicine 2019 May 6;216(5):1182-1198
Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport.
Ma H, Liu Z, Zhong CQ, Liu Y, Zhang Z, Liang Y, Li J, Han S, Han J
Molecular and cellular biology 2019 May 1;39(9)
Molecular and cellular biology 2019 May 1;39(9)
S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells.
Tsuneyoshi T, Kunimura K, Morihara N
Nitric oxide : biology and chemistry 2019 Mar 1;84:22-29
Nitric oxide : biology and chemistry 2019 Mar 1;84:22-29
Multi-omic Analyses Reveal Minimal Impact of the CRISPR-Cas9 Nuclease on Cultured Human Cells.
Qiang J, Ma Z, Xie X, Shi L, Geng Y, Hu J, Liu R, Liu N, Zhang Y
Journal of proteome research 2019 Mar 1;18(3):1054-1063
Journal of proteome research 2019 Mar 1;18(3):1054-1063
Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways.
Shen B, Zhao C, Wang Y, Peng Y, Cheng J, Li Z, Wu L, Jin M, Feng H
Journal of cellular and molecular medicine 2019 Jun;23(6):4063-4075
Journal of cellular and molecular medicine 2019 Jun;23(6):4063-4075
NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ.
Luan P, Jian W, Xu X, Kou W, Yu Q, Hu H, Li D, Wang W, Feinberg MW, Zhuang J, Xu Y, Peng W
Nature communications 2019 Jun 28;10(1):2882
Nature communications 2019 Jun 28;10(1):2882
Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress.
Lyu Z, Ji X, Chen G, An B
International immunopharmacology 2019 Jul;72:348-357
International immunopharmacology 2019 Jul;72:348-357
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-κB and activating Nrf2/HO-1 signaling pathways.
Li Z, Feng H, Wang Y, Shen B, Tian Y, Wu L, Zhang Q, Jin M, Liu G
International immunopharmacology 2019 Feb;67:465-472
International immunopharmacology 2019 Feb;67:465-472
The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Wang Y, Chen Y, Chen J, Wang L, Nie L, Long J, Chang H, Wu J, Huang C, Lei M
Nature communications 2019 Feb 4;10(1):564
Nature communications 2019 Feb 4;10(1):564
SUMOylation is required for PIPK1γ-driven keratinocyte migration and growth.
Ni W, Li Y, Cai L, Dong C, Fang H, Chen Y, Li H, Yao M, Xiao N
The FEBS journal 2019 Dec;286(23):4709-4720
The FEBS journal 2019 Dec;286(23):4709-4720
Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation.
Zhou YH, Sun L, Chen J, Sun WW, Ma L, Han Y, Jin X, Zhao QX, Li T, Lu H, Qiu X, Wang JH
mBio 2019 Dec 17;10(6)
mBio 2019 Dec 17;10(6)
Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.
Binning JM, Chesarino NM, Emerman M, Gross JD
Cell host & microbe 2019 Dec 11;26(6):739-747.e4
Cell host & microbe 2019 Dec 11;26(6):739-747.e4
Fibrinopeptide A induces C-reactive protein expression through the ROS-ERK1/2/p38-NF-κB signal pathway in the human umbilical vascular endothelial cells.
Zhao J, Xu SZ, Liu J
Journal of cellular physiology 2019 Aug;234(8):13481-13492
Journal of cellular physiology 2019 Aug;234(8):13481-13492
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Zheng J, Fan R, Wu H, Yao H, Yan Y, Liu J, Ran L, Sun Z, Yi L, Dang L, Gan P, Zheng P, Yang T, Zhang Y, Tang T, Wang Y
Nature communications 2019 Apr 8;10(1):1604
Nature communications 2019 Apr 8;10(1):1604
Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.
Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, Tong X, Chen L, Liu X, Zhang Y, Zhu X, Li X, Zhang H, Bai H, Yang Q, Ma J, Wiemer EAC, Xu Y, Chen Q
Nature communications 2019 Apr 17;10(1):1801
Nature communications 2019 Apr 17;10(1):1801
Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts.
Wei H, Lin L, Zhang X, Feng Z, Wang Y, You Y, Wang X, Hou Y
Biological research 2019 Apr 16;52(1):23
Biological research 2019 Apr 16;52(1):23
Asiatic Acid (AA) Sensitizes Multidrug-Resistant Human Lung Adenocarcinoma A549/DDP Cells to Cisplatin (DDP) via Downregulation of P-Glycoprotein (MDR1) and Its Targets.
Cheng Q, Liao M, Hu H, Li H, Wu L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):279-292
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):279-292
NLRP12 Promotes Mouse Neutrophil Differentiation through Regulation of Non-canonical NF-κB and MAPK(ERK1/2) Signaling.
Wang Q, Liu F, Zhang M, Zhou P, Xu C, Li Y, Bian L, Liu Y, Yao Y, Wang F, Fang Y, Li D
International journal of biological sciences 2018;14(2):147-155
International journal of biological sciences 2018;14(2):147-155
Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway.
Zhang M, Ding G, Zhou L, Shen T, Xu X, Zhao T, Jia S, Cao L
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Sep;38(9):413-422
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Sep;38(9):413-422
TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Zhu X, Li S
Scientific reports 2018 Nov 1;8(1):16167
Scientific reports 2018 Nov 1;8(1):16167
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang JY, Deng XY, Li YS, Ma XC, Feng JX, Yu B, Chen Y, Luo YL, Wang X, Chen ML, Fang ZX, Zheng FX, Li YP, Zhong Q, Kang TB, Song LB, Xu RH, Zeng MS, Chen W, Zhang H, Xie W, Gao S
Nature communications 2018 Mar 21;9(1):1165
Nature communications 2018 Mar 21;9(1):1165
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway.
Liu W, Zhao Z, Wang Y, Li W, Su Q, Jia Q, Zhang J, Zhang X, Shen J, Yin J
Cell death & disease 2018 Mar 1;9(3):343
Cell death & disease 2018 Mar 1;9(3):343
Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling.
Ren J, Jian F, Jiang H, Sun Y, Pan S, Gu C, Chen X, Wang W, Ning G, Bian L, Sun Q
International journal of oncology 2018 Jun;52(6):1934-1946
International journal of oncology 2018 Jun;52(6):1934-1946
Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.
Pu D, Zhao Y, Chen J, Sun Y, Lv A, Zhu S, Luo C, Zhao K, Xiao Q
Neuroscience 2018 Jun 15;381:35-45
Neuroscience 2018 Jun 15;381:35-45
Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress.
Lu M, Wu J, Hao ZW, Shang YK, Xu J, Nan G, Li X, Chen ZN, Bian H
Hepatology (Baltimore, Md.) 2018 Jul;68(1):317-332
Hepatology (Baltimore, Md.) 2018 Jul;68(1):317-332
The E3 ubiquitin ligase MuRF2 attenuates LPS-induced macrophage activation by inhibiting production of inflammatory cytokines and migration.
Bian H, Gao S, Zhang D, Zhao Q, Li F, Li X, Sun S, Song S, Li T, Zhu Q, Ren W, Qin C, Qi J
FEBS open bio 2018 Feb;8(2):234-243
FEBS open bio 2018 Feb;8(2):234-243
Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/β-catenin and osteoprotegerin/receptor activator for nuclear factor-κB ligand/cathepsin K signaling in ovariectomized rats.
Liu H, Zhu R, Wang L, Liu C, Ma R, Qi B, Chen B, Li L, Guo Y, Shi S, Jia Q, Niu J, Zhao D, Mo F, Gao S, Zhang D
Phytotherapy research : PTR 2018 Dec;32(12):2487-2500
Phytotherapy research : PTR 2018 Dec;32(12):2487-2500
Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization.
Xiong H, Nie X, Zou Y, Gong C, Li Y, Wu H, Qiu H, Yang L, Zhuang L, Zhang P, Zhang J, Wang Y, Xiong H
Journal of Cancer 2017;8(3):345-353
Journal of Cancer 2017;8(3):345-353
KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer.
Jia S, Qu T, Wang X, Feng M, Yang Y, Feng X, Ma R, Li W, Hu Y, Feng Y, Ji K, Li Z, Jiang W, Ji J
PloS one 2017;12(4):e0175058
PloS one 2017;12(4):e0175058
MTEP impedes the neuronal polarization and the activity of the Akt-NF-κB pathway in rat hippocampal neurons.
Zhang X, Hu M, Zhang L, An J, Yan W, Zhang Z, Liu J, Lu H, Chen X, Liu Y
Journal of neuroscience research 2017 Sep;95(9):1730-1744
Journal of neuroscience research 2017 Sep;95(9):1730-1744
Quercetin protects against atherosclerosis by inhibiting dendritic cell activation.
Lin W, Wang W, Wang D, Ling W
Molecular nutrition & food research 2017 Sep;61(9)
Molecular nutrition & food research 2017 Sep;61(9)
Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags.
Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Kummer MP, Brosseron F, Gieselmann V, Heneka MT
Journal of neuroscience methods 2017 Nov 1;291:95-100
Journal of neuroscience methods 2017 Nov 1;291:95-100
Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2.
Li Y, Wang L, Zhou L, Song Y, Ma S, Yu C, Zhao J, Xu C, Gao L
Molecular and cellular endocrinology 2017 May 5;446:70-80
Molecular and cellular endocrinology 2017 May 5;446:70-80
Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.
Zhang C, Mao HL, Cao Y
Scientific reports 2017 Jun 19;7(1):3769
Scientific reports 2017 Jun 19;7(1):3769
Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy.
Wu B, Cui J, Yang XM, Liu ZY, Song F, Li L, Jiang JL, Chen ZN
Cell death & disease 2017 Jul 13;8(7):e2925
Cell death & disease 2017 Jul 13;8(7):e2925
HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.
Huang Q, Niu Z, Han J, Liu X, Lv Z, Li H, Yuan L, Li X, Sun S, Wang H, Huang X
Oncotarget 2017 Aug 1;8(31):51123-51133
Oncotarget 2017 Aug 1;8(31):51123-51133
The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription.
Xiang N, He M, Ishaq M, Gao Y, Song F, Guo L, Ma L, Sun G, Liu D, Guo D, Chen Y
PloS one 2016;11(10):e0164471
PloS one 2016;11(10):e0164471
The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.
Koidl S, Eisenhardt N, Fatouros C, Droescher M, Chaugule VK, Pichler A
The international journal of biochemistry & cell biology 2016 Oct;79:478-487
The international journal of biochemistry & cell biology 2016 Oct;79:478-487
HMGB1 Enhances Drug Resistance and Promotes In Vivo Tumor Growth of Lung Cancer Cells.
Zheng H, Chen JN, Yu X, Jiang P, Yuan L, Shen HS, Zhao LH, Chen PF, Yang M
DNA and cell biology 2016 Oct;35(10):622-627
DNA and cell biology 2016 Oct;35(10):622-627
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, Xu J, Tian D
Scientific reports 2016 Jun 8;6:27597
Scientific reports 2016 Jun 8;6:27597
Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation.
Nie D, Zhang D, Dai J, Zhang M, Zhao X, Xu W, Chen Z, Wang L, Wang Z, Qiao Z
Biology of reproduction 2016 Feb;94(2):31
Biology of reproduction 2016 Feb;94(2):31
The long noncoding RNA ASNR regulates degradation of Bcl-2 mRNA through its interaction with AUF1.
Chen J, Liu L, Wei G, Wu W, Luo H, Yuan J, Luo J, Chen R
Scientific reports 2016 Aug 31;6:32189
Scientific reports 2016 Aug 31;6:32189
Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity.
Wu J, Guo W, Lin SZ, Wang ZJ, Kan JT, Chen SY, Zhu YZ
Cell death & disease 2016 Aug 18;7(8):e2339
Cell death & disease 2016 Aug 18;7(8):e2339
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
Dong Y, Ye W, Yang J, Han P, Wang Y, Ye C, Weng D, Zhang F, Xu Z, Lei Y
Biochemical and biophysical research communications 2016 Apr 29;473(2):648-53
Biochemical and biophysical research communications 2016 Apr 29;473(2):648-53
Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice.
Chen H, Sun Y, Lai L, Wu H, Xiao Y, Ming B, Gao M, Zou H, Xiong P, Xu Y, Tan Z, Gong F, Zheng F
Neuroscience 2015 Nov 12;308:157-68
Neuroscience 2015 Nov 12;308:157-68
Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via nuclear factor-κB activation.
Liu H, Wang ZC, Bai YG, Cai Y, Yu JW, Zhang HJ, Bao JX, Ren XL, Xie MJ, Ma J
Clinical and experimental pharmacology & physiology 2015 May;42(5):510-9
Clinical and experimental pharmacology & physiology 2015 May;42(5):510-9
Astrocyte elevated gene-1 promotes progression of cervical squamous cell carcinoma by inducing epithelial-mesenchymal transition via Wnt signaling.
Song E, Yu W, Xiong X, Kuang X, Ai Y, Xiong X
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2015 Mar;25(3):345-55
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2015 Mar;25(3):345-55
Rho GDIalpha Modulates Rabbit Trophoblast Stem Cell Survival and Migration.
Zhang J, Li T, Ji W, Yu Y, Tan T
Biology of reproduction 2015 Dec;93(6):144
Biology of reproduction 2015 Dec;93(6):144
Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication.
Bai L, Zhang W, Tan L, Yang H, Ge M, Zhu C, Zhang R, Cao Y, Chen J, Luo Z, Ho W, Liu F, Wu K, Wu J
Journal of molecular cell biology 2015 Dec;7(6):543-56
Journal of molecular cell biology 2015 Dec;7(6):543-56
Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells.
Chen L, Zhang W, Liang HF, Zhou QF, Ding ZY, Yang HQ, Liu WB, Wu YH, Man Q, Zhang BX, Chen XP
Cell communication and signaling : CCS 2014 Mar 17;12:18
Cell communication and signaling : CCS 2014 Mar 17;12:18
Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells.
Tan T, Lu B, Zhang J, Niu Y, Si W, Wei Q, Ji W
Stem cells and development 2014 Apr 15;23(8):813-22
Stem cells and development 2014 Apr 15;23(8):813-22
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Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Lamin B1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human Lamin B1. This antibody recognizes human,mouse,rat antigen. The Lamin B1 antibody has been validated for the following applications: ELISA, WB, IF, FC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Western blot on multiple cells/tissues with anti-LMNB1 (66095-1-Ig) at dilution 1:20000.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells using 66095-1-Ig( Lamin B1 Antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
