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- References [531]
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- Product number
- 66095-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#66095-1-Ig, RRID:AB_11232208
- Product name
- Lamin B1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Lamin B1 antibody (Cat. #66095-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3C10G12
- Vial size
- 150ul
Submitted references β-Cryptoxanthin Confers Radioprotection against Intestinal Injury via NRF2-Mediated Antioxidant Response and Gut Microbiota Reprogramming.
RNA-binding motif protein 15 promotes gastric cancer growth and drug resistance via USP10-mediated deubiquitination and stabilization of nuclear NRF2.
Agomelatine Targets Aquaporin-4 Polarization to Rescue Glymphatic Dysfunction in Parkinson's Disease.
RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy.
Phenylephrine attenuates LPS-induced lung injury via Foxh1/GSK-3β/β-catenin-mediated alveolar epithelial cell differentiation in ARDS.
Proline/serine-rich coiled-coil 1 alleviates atherosclerosis via remodeling tryptophan metabolism mediated by Akkermansia muciniphila.
Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF-κB pathway.
Activation of the Nrf2 Signaling Pathway by a Ginseng-Salvia Root-Notoginseng Composite Alleviates Ulcerative DSS-Induced Colitis via Restoring Gut Microbiota and the Intestinal Barrier.
ECHOS enables spatial epigenome profiling at subcellular resolution.
Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism.
HIV-1 Nef induces astrocytes proliferation, inflammatory response, A1-like astrocytes polarization and subsequent neuronal apoptosis via NF-κB signaling pathway.
BEX2 influences the MCL1-Hedgehog signaling axis to regulate the potential of stemness characterization in colorectal cancer.
The lamin A/C-P4HB interaction axis regulates endoplasmic reticulum stress and apoptosis in myocardial ischemia-reperfusion injury via a calreticulin-associated mechanism.
λ-Carrageenan regulates antiviral responses by targeting classical NF-κB and IRF3-mediated signaling pathways.
Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification.
RADA16 and SAAP148 Peptide-Modified Collagen Self-Assembled Hydrogels for Accelerated Healing of Infected Wounds.
Reversal of diet-induced obesity by central insulin sensitizer FSTL1.
METTL1 interacts with XPO5 to modulate pre-miRNA export.
Nuclear factor IC promoting porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppressing type I interferon transcription.
CD48 is a novel immune checkpoint on tumour-associated macrophages in hepatocellular carcinoma.
Promoting the nuclear retention of HMGB1 attenuates astrocyte senescence.
Lycium barbarum polysaccharide LBP3 alleviates 5-Fluorouracil-induced intestinal injury via a mechanism associated with activating Nrf2 and improving mitochondrial function.
OTUD1 delays wound healing by regulating endothelial function and angiogenesis in diabetic mice.
Proteins Lamin A and SUN1 are exclusively decreased in nuclear grade 4 clear cell renal cell carcinoma.
BAP1 Loss Induces Senescence and Enhances the Response to Radiation Therapy and Senolytics.
Development of DOT1L-Targeted Protein Degraders for Treating MLL-r Leukemia.
ANGPTL8 regulates glucose metabolism in gestational diabetes mellitus mice, and proteomic analysis reveals the PI3K/Akt pathway plays its role in insulin-resistance HepG(2) cells.
PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2.
Cellular Senescence Drives Zinc Accumulation and Transporter Dysregulation in Intestinal Epithelial Cells.
Tet2 deficiency-induced expansion of monocyte-derived macrophages promotes liver fibrosis.
Investigating the impact and mechanism of Licochalcone B derivative CTG12 on NLRP3 inflammasome.
CBFA2T2: a novel H3K27 reader regulating metabolism and tumor growth.
Mitochondrial DNA drives NLRP3-IL-1β axis activation in microglia by binding to NLRP3, leading to neurodegeneration in Parkinson's disease models.
Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis.
TDP-43 pathology triggers neuroinflammation and cognitive impairment by inducing microglial necroptosis.
Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage-Induced Mitochondrial Apoptosis and Parthanatos-Like Cell Death.
Macrophages with ITIH4 overexpression attenuate inflammatory responses and regulate intestinal epithelial cells.
Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling.
A comparative study of capacitation-mediated changes in whole mouse sperm proteome.
Low-dose extracorporeal shock wave attenuates sepsis-related acute lung injury by targeting mitochondrial dysfunction and pyroptosis crosstalk in type II alveolar epithelial cells.
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy.
Aryl hydrocarbon receptor facilitates HSV-1 lytic infection by enhancing viral gene transcription and receptor expression.
Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease.
Genetic association and functional implications of AhR gene polymorphism on preeclampsia.
MgSO(4) alleviates hippocampal neuroinflammation and BBB damage to resist CMS-induced depression.
SENP1 promotes p27kip1 nuclear export though enhanced SUMOylation in cholangiocarcinoma leading to increased cell proliferation and chemoresistance.
Glutaredoxin 1 enhances endothelial cell angiogenesis by reducing VEGFA S-glutathionylation and delays vascular endothelial cell senescence.
KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity.
The Extremely Low Mechanical Force Generated by Nano-Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons.
Protective Effects of Ganoderma Triterpenoids Supplementation Against Myocardial Injury in Exhaustion Exercise Mice via Regulation of the Keap1/Nrf2/HO-1 Pathway.
Osimertinib resistance-based immune prognostic related gene signature in EGFR mutant lung adenocarcinoma, in which PSMD11 promotes tumor progression.
Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow.
Oxidative modulation of Piezo1 channels.
Pretreatment with alendronate augments lipid A-induced IFN-β production via upregulation of cGAS expression.
Liquid-liquid phase separation of GPS2-LATS1 promotes colorectal cancer progression by reprogramming lipid metabolism.
MUC1-C auto-regulatory complex with EBNA1 is responsible for latent Epstein-Barr virus-associated gastric cancer progression.
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells.
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.
The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity.
HIV proviral transcription and infectivity are enhanced by neddylation.
Investigation of the material basis and mechanism of Qingfei Paidu granules in treating LPS-induced acute pneumonia using UPLC-Q-TOF-MS/MS, network pharmacology, molecular docking and experimental verification.
Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice.
Deacetylase SIRT1 modulates antiviral innate immunity and autoimmune diseases.
Targeting MTPN sensitizes pancreatic cancer of wild-type BRCA1/2 to Cisplatin-based chemotherapy.
Obacunone ameliorates high-fat diet-induced MAFLD by regulating the PPARγ-FABP1/CD36 axis and the gut-liver crosstalk.
HuB serves as the central hub for connecting HuR-related mRNAs with translation machinery in inflammation.
Sestrin2 ameliorates LPS-induced cardiomyocyte injury by inhibiting ferroptosis via the Nrf2/HO-1 pathway.
Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling.
LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55-Mediated Signalling in Spinal Cord Injury.
The VCPKMT-VCP-HDAC1 axis inhibits colorectal cancer by conferring sensitivity to ferroptosis.
TERT's protective effect on trophoblast cells: Reducing mitochondrial ROS.
RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development.
Nuclear m(6)A modification regulates satellite transcription and chromosome segregation.
PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells.
Vitamin C Inhibits Scale Drop Disease Virus Infectivity by Targeting Nrf2 to Reduce Ferroptosis.
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin-Driven TFEB Nuclear Translocation.
The potential role of the SIRT1-Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress.
METTL3-mediated m(6)A modification regulates muscle development by promoting TM4SF1 mRNA degradation in P-body via YTHDF2.
Beyond a ferroptosis inducer: erastin can suppress nutrient deprivation induced cell death in the intervertebral disc.
Serum starvation induces cytosolic DNA trafficking via exosome and autophagy-lysosome pathway in microglia.
STAT1 mediates the pro-inflammatory role of GBP5 in colitis.
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness.
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Growth Arrest-specific 1 Inhibits Keap1/Nrf2 Signaling Transduction in the Activation of the Ferroptosis Program in Retinal Müller Cells.
Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cells.
A thermosensitive hydrogel with synergistic stromal targeting and antitumor immunity modulation for pancreatic cancer immunotherapy.
Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming.
Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.
Oleanolic Acid Up-Regulated UGT1A1 and Antagonized Inflammation by Affecting the Binding of PXR and PKCα to HSP90α and SRC1.
YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2.
Activation of toll-like receptor 2 promotes the expression of inflammatory mediators and cell proliferation of human polycystic kidney disease cells.
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
DHX9-mediated epigenetic silencing of BECN1 contributes to impaired autophagy and tumor progression in breast cancer via recruitment of HDAC5.
The highly conserved PIWI-interacting RNA CRAPIR antagonizes PA2G4-mediated NF110-NF45 disassembly to promote heart regeneration in mice.
NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL.
CircRNA-RBAC induces cardiac repair by promoting ribosome biogenesis and cell cycle progression in cardiomyocytes.
LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction.
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome.
Extract of Nanhaia speciosa J. Compton & Schrire alleviates LPS-induced acute lung injury via the NF-κB/Nrf2/AQPs pathway.
Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer.
Overexpression of Apolipoprotein A-I Alleviates Insulin Resistance in MASLD Mice Through the PPARα Pathway.
ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure.
Spatial regulation of NSUN2-mediated tRNA m5C installation in cognitive function.
Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4.
Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome.
CCAAT/Enhancer-Binding Protein Beta Nitration Participates in Hyperhomocysteinemia-Induced Cardiomyocyte Autophagic Flux Blockage by Inhibiting Transcription Factor EB Transcription.
Targeting CDK2 Confers Vulnerability to Lenvatinib Via Driving Senescence in Anaplastic Thyroid Cancer.
Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors.
Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression.
Targeting the NLRP3 in macrophages contributes to senescence cell clearance in radiation-induced skin injury.
Nucleolar ribosomal RNA synthesis continues in differentiating lens fiber cells until abrupt nuclear degradation required for ocular lens transparency.
Nuclear factor IX could facilitate porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppresses retinoic acid-inducible gene I (RIG-I) and toll-like receptor 3 (TLR-3)-mediated type I interferon transcription.
Indole modulates lipoteichoic acid-induced inflammatory response in duck intestinal epithelial cells.
Single-Cell and Spatial Transcriptomics-Based Research Reveals Association Between M2a Macrophages and Tumor Spread through Air Spaces in Lung Adenocarcinoma.
Genetic and functional analysis of ZMIZ1 in neurodevelopmental disorder with dysmorphic facies and distal skeletal anomalies (NEDDFSA): insights from muscle cells and signaling pathways.
Multi-omics analysis reveals that ALYREF-mediated m(5)C modification promotes platinum resistance in ovarian cancer via the NSUN2/ALYREF/LGR4 axis.
Targeting TRIM59 impairs RNA splicing and promotes neuroblastoma differentiation and therapeutic responses.
Targeting KRAS Inhibitor-Resistant Pancreatic Cancer with an MUC1-C Antibody-Drug Conjugate.
A SETD2-CDK1-lamin axis maintains nuclear morphology and genome stability.
DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy.
Sigma-1R-Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS.
Dehydroabietic acid protects against cerebral ischaemia-reperfusion injury by modulating microglia-mediated neuroinflammation via targeting PKCδ.
Downregulated TFPI2 Accelerates Skin Aging by Repressing the Cell Cycle through Phosphoinositide 3-Kinase/Protein Kinase B/CDC6 Pathway.
Oncogenic GOPC-ROS1 fusion promotes the formation of lymphatic malformations by impairing tight junction and its crizotinib resistance through repressing ferroptosis.
Artemisia annua L. leaf extracts suppress influenza virus infection by targeting the viral nucleoprotein and blocking mitochondria-mediated apoptosis.
The OLR1/NF-κB feedback loop exacerbates HIV-1 Tat-induced microglial inflammatory response and neuronal apoptosis.
3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury.
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.
Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer.
MUC1-C dependency in drug resistant HR+/HER2- breast cancer identifies a new target for antibody-drug conjugate treatment.
EMG1 methyltransferase activity affects ribosome occupancy at KSHV uORFs.
Decursin induces FLT3-ITD acute myeloid leukemia cell apoptosis by increasing the expression of the ubiquitin-conjugase UBE2L6.
IP6K1 Rewires LKB1 Signaling to Mediate Hyperglycemic Endothelial Senescence.
Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis.
Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway.
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Celastrol alleviates diabetic vascular injury via Keap1/Nrf2-mediated anti-inflammation.
NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway.
A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4.
DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.
Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study.
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells.
Phospholipase D3 regulates TFEB/TFE3 metabolism to maintain lysosomal homeostasis.
Nuclear translocation of nucleotide enzyme Phosphoglucomutase 2 governs DNA damage response and anti-tumor immunity.
Apo-12'-capsorubinal exhibits anti-inflammatory effects and activates nuclear factor erythroid 2-related factor 2 in RAW264.7 macrophages.
CHAC1 blockade suppresses progression of lung adenocarcinoma by interfering with glucose metabolism via hijacking PKM2 nuclear translocation.
Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion.
Continuous nucleolar ribosomal RNA synthesis in differentiating lens fiber cells until abrupt nuclear degradation required for ocular lens transparency.
Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells.
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.
Spinster homolog 2 (SPNS2) deficiency drives endothelial cell senescence and vascular aging via promoting pyruvate metabolism mediated mitochondrial dysfunction.
Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer.
SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8(+) T cell activation.
Stress granules are not present in Kras mutant cancers and do not control tumor growth.
Nup210 Promotes Colorectal Cancer Progression by Regulating Nuclear Plasma Transport.
The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.
Optimized simple culture protocol for inducing mature myotubes from MYOD1-overexpressed human iPS cells.
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
UBC9-mediated SUMOylation of Lamin B1 enhances DNA-damage-induced nuclear DNA leakage and autophagy after spinal cord injury.
Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover.
A mixture of extracts from natural ingredients reduces the neurotoxic polarization of microglia via modulating NF-κB/NF-E2-related factor 2 activation.
Peripherally targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels.
IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA viruses.
LncRNA-LncDACH1 mediated phenotypic switching of smooth muscle cells during neointimal hyperplasia in male arteriovenous fistulas.
EZH2 inhibition induces senescence via ERK1/2 signaling pathway in multiple myeloma.
Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases.
Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis.
Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB- Dependent Inflammation.
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation.
RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity.
Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
Rag-GTPase-TFEB/TFE3 axis controls B cell mitochondrial fitness and humoral immunity independent of mTORC1.
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging.
The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.
IL-35 ameliorates lipopolysaccharide-induced endothelial dysfunction by inhibiting endothelial-to-mesenchymal transition.
Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity.
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
Vagal-α7 nicotinic acetylcholine receptor signaling exacerbates influenza severity by promoting lung epithelial cell infection.
Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies.
New compatible pair of TCM: Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation.
NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancer.
CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1.
Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis.
SMYD5 is a regulator of the mild hypothermia response.
Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei.
Cysteine and glycine-rich protein 2 retards platelet-derived growth factor-BB-evoked phenotypic transition of airway smooth muscle cells by decreasing YAP/TAZ activity.
Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-κB pathway.
Unveiling the immunomodulatory mechanism of polysaccharides from Polygonum cyrtonema based on RNA-seq.
Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT/GSK3β/NRF2/GPX4 axis.
Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases.
Protective effects of sodium humate on the intestinal barrier damage of Salmonella Typhimurium-challenged broilers.
Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells.
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development.
FOXP3(+) regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity.
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling.
Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module.
Agomelatine promotes differentiation of oligodendrocyte precursor cells and preserves white matter integrity after cerebral ischemic stroke.
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes.
Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation.
Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway.
Siglec-5 as a novel receptor mediates endothelial cells oxLDL transcytosis to promote atherosclerosis.
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis.
Effects of Antioxidant Amino Acids on Cancer Sarcopenia.
Neuregulin-1 reduces Doxorubicin-induced cardiotoxicity by upregulating YAP to inhibit senescence.
Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis.
Role of AhR-Hsp90-MDM2-mediated VDR ubiquitination in PM2.5-induced renal toxicity.
The essential role of TTC28 in maintaining chromosomal stability via HSPA8 chaperone-mediated autophagy.
PHF2-mediated H3K9me balance orchestrates heterochromatin stability and neural progenitor proliferation.
Tryptanthrin suppresses multiple inflammasome activation to regulate NASH progression by targeting ASC protein.
Activation of nicotinic acetylcholine receptor α7 subunit limits Zika viral infection via promoting autophagy and ferroptosis.
SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis.
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma.
SMYD5 is a regulator of the mild hypothermia response.
PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury.
Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells.
Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action.
CircNOP14 increases the radiosensitivity of hepatocellular carcinoma via inhibition of Ku70-dependent DNA damage repair.
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
Mind the Viscous Modulus: The Mechanotransductive Response to the Viscous Nature of Isoelastic Matrices Regulates Stem Cell Chondrogenesis.
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions.
Development of a Cell Culture Model for Inducible SARS-CoV-2 Replication.
PICK1 inhibits the malignancy of nasopharyngeal carcinoma and serves as a novel prognostic marker.
TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis.
Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability.
Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control.
Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns.
Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis.
Denervation aggravates renal ischemia reperfusion injury via BMAL1-mediated Nrf2/ARE pathway.
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Molecular mechanism by which RRM2-inhibitor (cholagogue osalmid) plus bafilomycin A1 cause autophagic cell death in multiple myeloma.
Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma.
Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis.
Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma.
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export.
Regulatory architecture of housekeeping genes is driven by promoter assemblies.
The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization.
IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma.
Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation.
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells.
YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells.
Disruption of the ADAM17/NF-κB feedback loop in astrocytes ameliorates HIV-1 Tat-induced inflammatory response and neuronal death.
The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.
Single cell RNA-seq resolution revealed CCR1(+)/SELL(+)/XAF(+) CD14 monocytes mediated vascular endothelial cell injuries in Kawasaki disease and COVID-19.
Charged multivesicular body protein 2B ameliorates biliary injury in the liver from donation after cardiac death rats via autophagy with air-oxygenated normothermic machine perfusion.
Anti-oxidative-initiated cognitive impairment amelioration in Alzheimer's disease model rats through preventive transcutaneous electrical acupoint stimulation.
Role of ionizing radiation activated NRF2 in lung cancer radioresistance.
SMYD3 drives the proliferation in gastric cancer cells via reducing EMP1 expression in an H4K20me3-dependent manner.
Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice.
SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/β-catenin signaling pathway.
Metformin synergistically enhances the antitumour activity of Lenvatinib in hepatocellular carcinoma by altering AKT-FOXO3 signalling pathway.
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Decreased lamin A and B1 expression results in nuclear enlargement in serous ovarian carcinoma, whereas lamin A-expressing tumor cells metastasize to lymph nodes.
Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway.
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis.
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury.
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Absence of indoleamine 2,3‑dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice.
β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage.
Influence of RRM, RGG and Potential Phosphorylated Sites in Cold-Inducible Protein RBM3 on its Subcellular Localization and Neuroprotective Effects.
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
The Integrator complex regulates microRNA abundance through RISC loading.
UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer.
FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway.
The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells.
Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells.
Conessine inhibits enveloped viruses replication through up-regulating cholesterol level.
Function of m(5)C RNA methyltransferase NOP2 in high-grade serous ovarian cancer.
A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity.
HIV-1 subtype B Tat enhances NOTCH3 signaling in astrocytes to mediate oxidative stress, inflammatory response, and neuronal apoptosis.
Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin.
Characterizing microglial senescence: Tau as a key player.
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation.
HHEX suppresses advanced thyroid cancer by interacting with TLE3.
Carteolol triggers senescence via activation of β-arrestin-ERK-NOX4-ROS pathway in human corneal endothelial cells in vitro.
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats.
LPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis.
Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway.
Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice.
Allyl methyl trisulfide protected against LPS-induced acute lung injury in mice via inhibition of the NF-κB and MAPK pathways.
Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B-Lamin B1 Interaction in Alcoholic Fatty Liver Disease.
Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway.
The Protective Effect of Evodiamine in Osteoarthritis: An In Vitro and In Vivo Study in Mice Model.
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Hypoxic Cell-Derived Extracellular Vesicles Aggravate Rectal Injury Following Radiotherapy via MiR-122-5p.
Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1.
RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ.
Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe.
Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte.
A Novel, Fully Spliced, Accessory Gene in Equine Lentivirus with Distinct Rev-Responsive Element.
Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation.
GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis.
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression.
Ultraviolet B irradiation induces senescence of human corneal endothelial cells in vitro by DNA damage response and oxidative stress.
Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells.
Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage.
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Free and Bound Phenolics of Laird Lentil (Lens culinaris) Hulls and the Anti-inflammatory Activity of their Digestive Products via Crosstalk between NF-κB and Keap1-Nrf2 Signaling Pathways in HT-29 Cells.
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.
Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation.
Exposure to Multiwall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis.
BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis.
Major Vault Protein Prevents Atherosclerotic Plaque Destabilization by Suppressing Macrophage ASK1-JNK Signaling.
Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP(+)-induced oxidative stress.
Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner.
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit.
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.
Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition.
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs.
NPM1 promotes cell proliferation by targeting PRDX6 in colorectal cancer.
Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription.
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
TRIM62 silencing represses the proliferation and invasion and increases the chemosensitivity of hepatocellular carcinoma cells by affecting the NF-κB pathway.
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation.
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
DNA Repair Factor Poly(ADP-Ribose) Polymerase 1 Is a Proviral Factor in Hepatitis B Virus Covalently Closed Circular DNA Formation.
TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1.
METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice.
3-(3-Hydroxyphenyl)propionic acid, a microbial metabolite of quercetin, inhibits monocyte binding to endothelial cells via modulating E-selectin expression.
Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection.
Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes.
The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
RETRACTED: TRIM21 deficiency confers protection from OGD/R-induced oxidative and inflammatory damage in cultured hippocampal neurons through regulation of the Keap1/Nrf2 pathway.
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction.
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
HIV-1 Tat drives the Fabp4/NF-κB feedback loop in microglia to mediate inflammatory response and neuronal apoptosis.
Blockade of CBX4-mediated β-catenin SUMOylation attenuates airway epithelial barrier dysfunction in asthma.
Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3.
Onset of p53/NF-κB signaling crosstalk in human melanoma cells in response to anti-cancer theabrownin.
METTL3 preferentially enhances non-m(6)A translation of epigenetic factors and promotes tumourigenesis.
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export.
Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism.
Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway.
YB-1 Recruits Drosha to Promote Splicing of pri-miR-192 to Mediate the Proangiogenic Effects of H(2)S.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Antioxidant Activity of Acanthopanax senticosus Flavonoids in H(2)O(2)-Induced RAW 264.7 Cells and DSS-Induced Colitis in Mice.
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.
PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway.
Arid4b alters cell cycle and cell death dynamics during mouse embryonic stem cell differentiation.
Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1.
Protective Effect of Jiang Tang Xiao Ke Granules against Skeletal Muscle IR via Activation of the AMPK/SIRT1/PGC-1α Signaling Pathway.
GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy.
Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Transcription Coactivator BCL3 Acts as a Potential Regulator of Lipid Metabolism Through the Effects on Inflammation.
Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.
PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress.
Angelica Polysaccharide Antagonizes 5-FU-Induced Oxidative Stress Injury to Reduce Apoptosis in the Liver Through Nrf2 Pathway.
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration.
MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling.
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation.
Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization.
ATRX proximal protein associations boast roles beyond histone deposition.
DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma.
KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.
Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation.
TET2 Inhibits PD-L1 Gene Expression in Breast Cancer Cells through Histone Deacetylation.
The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury.
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
miR-142-3p reduces the viability of human cervical cancer cells by negatively regulating the cytoplasmic localization of HMGB1.
Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway.
PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells.
ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.
Inhibitory activity of flavonoids from Ephedrae Herba on hypoxia signaling in PANC-1 cells and the evaluation of their mechanisms.
Molecular Mechanism of Platelet-Derived Growth Factor (PDGF)-BB-Mediated Protection Against MPP(+) Toxicity in SH-SY5Y Cells.
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP.
Spermidine at supraphysiological doses induces oxidative stress and granulosa cell apoptosis in mouse ovaries.
Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats.
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer.
Regulatory role of DEPTOR‑mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma.
Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair.
Abnormal nitration and S-sulfhydration modification of Sp1-CSE-H(2)S pathway trap the progress of hyperhomocysteinemia into a vicious cycle.
Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux.
Increased long noncoding RNA LINK-A contributes to rheumatoid synovial inflammation and aggression.
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate.
The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation.
Interaction of NEP with G Protein Pathway Suppressor 2 Facilitates Influenza A Virus Replication by Weakening the Inhibition of GPS2 to RNA Synthesis and Ribonucleoprotein Assembly.
Discovering the Mechanisms of Wikstroelide E as a Potential HIV-Latency-Reversing Agent by Transcriptome Profiling.
Seco-type β-Apocarotenoid Generated by β-Carotene Oxidation Exerts Anti-inflammatory Effects against Activated Macrophages.
Deletion of LBR N-terminal domains recapitulates Pelger-Huet anomaly phenotypes in mouse without disrupting X chromosome inactivation.
Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9(+) cells to prevent the development of liver cancer in a mouse model.
Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator.
Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.
β-Actin facilitates etoposide-induced p53 nuclear import.
Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway.
Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway.
Metformin Ameliorates Gestational Diabetes Mellitus-Induced Endothelial Dysfunction via Downregulation of p65 and Upregulation of Nrf2.
SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β-catenin signaling pathway.
Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas.
Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells.
Evaluation of cancer-derived myocardial impairments using a mouse model.
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice.
Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer.
Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis.
Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity.
Arsenic trioxide induces gasdermin E mediated pyroptosis in astroglioma cells.
23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9.
Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
Polymorphisms in Human APOBEC3H Differentially Regulate Ubiquitination and Antiviral Activity.
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging.
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABA(A) receptors.
Oncogenic role of TYRO3 receptor tyrosine kinase in the progression of pancreatic cancer.
Ribosome 18S m(6)A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.
Tet2 regulates Barx2 expression in undifferentiated and early differentiated mouse embryonic stem cells.
The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43.
BPTES inhibits anthrax lethal toxin-induced inflammatory response.
Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly.
Effects of peptidoglycan on the development of steatohepatitis.
OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3.
CACYBP Enhances Cytoplasmic Retention of P27(Kip1) to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.
Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage.
Deficiency of emerin contributes differently to the pathogenesis of skeletal and cardiac muscles in LmnaH222P/H222P mutant mice.
Nigericin Promotes NLRP3-Independent Bacterial Killing in Macrophages.
Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate.
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P(2) and extended synaptotagmins.
Probiotic effect on Helicobacter pylori attachment and inhibition of inflammation in human gastric epithelial cells.
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
ACLY facilitates colon cancer cell metastasis by CTNNB1.
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.
Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance.
USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.
The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING.
The phosphorylation of Tudor-SN mediated by JNK is involved in the regulation of milk protein synthesis induced by prolactin in BMECs.
Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport.
S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells.
Multi-omic Analyses Reveal Minimal Impact of the CRISPR-Cas9 Nuclease on Cultured Human Cells.
Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways.
NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ.
Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-κB and activating Nrf2/HO-1 signaling pathways.
The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
SUMOylation is required for PIPK1γ-driven keratinocyte migration and growth.
Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation.
Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.
Fibrinopeptide A induces C-reactive protein expression through the ROS-ERK1/2/p38-NF-κB signal pathway in the human umbilical vascular endothelial cells.
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.
Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts.
Asiatic Acid (AA) Sensitizes Multidrug-Resistant Human Lung Adenocarcinoma A549/DDP Cells to Cisplatin (DDP) via Downregulation of P-Glycoprotein (MDR1) and Its Targets.
NLRP12 Promotes Mouse Neutrophil Differentiation through Regulation of Non-canonical NF-κB and MAPK(ERK1/2) Signaling.
Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway.
TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway.
Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling.
Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.
Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress.
The E3 ubiquitin ligase MuRF2 attenuates LPS-induced macrophage activation by inhibiting production of inflammatory cytokines and migration.
Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/β-catenin and osteoprotegerin/receptor activator for nuclear factor-κB ligand/cathepsin K signaling in ovariectomized rats.
Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization.
KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer.
MTEP impedes the neuronal polarization and the activity of the Akt-NF-κB pathway in rat hippocampal neurons.
Quercetin protects against atherosclerosis by inhibiting dendritic cell activation.
Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags.
Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2.
Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.
Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy.
HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.
The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription.
The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.
HMGB1 Enhances Drug Resistance and Promotes In Vivo Tumor Growth of Lung Cancer Cells.
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation.
The long noncoding RNA ASNR regulates degradation of Bcl-2 mRNA through its interaction with AUF1.
Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity.
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice.
Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via nuclear factor-κB activation.
Astrocyte elevated gene-1 promotes progression of cervical squamous cell carcinoma by inducing epithelial-mesenchymal transition via Wnt signaling.
Rho GDIalpha Modulates Rabbit Trophoblast Stem Cell Survival and Migration.
Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication.
Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells.
Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells.
Zhang M, Liu Y, Ma W, Wang J, He N, Song H, Gu Y, Yang M, Lu X, Sun J, Xu C, Du L, Yuan Y, Wang Y, Ji K, Liu Q
International journal of biological sciences 2026;22(5):2581-2602
International journal of biological sciences 2026;22(5):2581-2602
RNA-binding motif protein 15 promotes gastric cancer growth and drug resistance via USP10-mediated deubiquitination and stabilization of nuclear NRF2.
Ma Z, Xu Z, Xu J, Chen C, Niu W, Wang Y, Qian Y, Zhang X, Yang M, Stefan SM, Gan L, Wang S, Wang B
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 May;86:101376
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 May;86:101376
Agomelatine Targets Aquaporin-4 Polarization to Rescue Glymphatic Dysfunction in Parkinson's Disease.
Wang S, Wu D, Chen G, Yuan J, Zheng L, Huang X, Liu X, Kang Z, Feng Y, Zhang J, Cai W, Lu Z, Wei L
Neuroscience bulletin 2026 May;42(5):1079-1094
Neuroscience bulletin 2026 May;42(5):1079-1094
RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy.
Gao Y, Zhao Z, Chen X, Li N, Li Y, Guan J, Dai H
Cell death and differentiation 2026 May;33(5):945-958
Cell death and differentiation 2026 May;33(5):945-958
Phenylephrine attenuates LPS-induced lung injury via Foxh1/GSK-3β/β-catenin-mediated alveolar epithelial cell differentiation in ARDS.
Zeng Z, Yin Y, Cong Z, Wei S, Wei X, Shen Z, Ge Q, Zhu X
International immunopharmacology 2026 May 15;177:116541
International immunopharmacology 2026 May 15;177:116541
Proline/serine-rich coiled-coil 1 alleviates atherosclerosis via remodeling tryptophan metabolism mediated by Akkermansia muciniphila.
Wu Q, Hu K, Wang Q, Luo T, Hu L, Liu J, Zou D, Hu J, Guo Z
Experimental & molecular medicine 2026 Mar;58(3):848-863
Experimental & molecular medicine 2026 Mar;58(3):848-863
Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF-κB pathway.
Chen H, Xu S, Chen B, Xiong X, Hu J, Wu Y, Wang T, Wang H
Journal of diabetes investigation 2026 Mar;17(3):395-410
Journal of diabetes investigation 2026 Mar;17(3):395-410
Activation of the Nrf2 Signaling Pathway by a Ginseng-Salvia Root-Notoginseng Composite Alleviates Ulcerative DSS-Induced Colitis via Restoring Gut Microbiota and the Intestinal Barrier.
Lyu X, Zhang L, Si J, Dai S, Su H, Lyu S, Chen L, Sun J, Jin X, Li H
Antioxidants (Basel, Switzerland) 2026 Mar 4;15(3)
Antioxidants (Basel, Switzerland) 2026 Mar 4;15(3)
ECHOS enables spatial epigenome profiling at subcellular resolution.
Cao Q, Xu Q, Ueda Y, Rajachandran S, Sharma M, Zhang X, Mahendroo M, Grow EJ, Chen H
bioRxiv : the preprint server for biology 2026 Mar 27;
bioRxiv : the preprint server for biology 2026 Mar 27;
Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism.
Zhang ZH, Qiu YT, Cao JY, Huang YF, Lan YL, Zhao YL, Wu F, Wang CL, Tang GR, Ji JY, Zhang Z, Luo GZ
Cell proliferation 2026 Mar 12;:e70196
Cell proliferation 2026 Mar 12;:e70196
HIV-1 Nef induces astrocytes proliferation, inflammatory response, A1-like astrocytes polarization and subsequent neuronal apoptosis via NF-κB signaling pathway.
Zhang L, Yao H, Tao W, Cao D, Gao L
Journal of neurovirology 2026 Mar 11;32(2)
Journal of neurovirology 2026 Mar 11;32(2)
BEX2 influences the MCL1-Hedgehog signaling axis to regulate the potential of stemness characterization in colorectal cancer.
Qian Y, Wei J, Bian Y, Tan Y, Fang Y, Chen L, Jiang K, Fu D, Ge X, Ling T, Xiao Q, Ding K, Hu Y
Cancer biology & medicine 2026 Mar 10;23(2):276-93
Cancer biology & medicine 2026 Mar 10;23(2):276-93
The lamin A/C-P4HB interaction axis regulates endoplasmic reticulum stress and apoptosis in myocardial ischemia-reperfusion injury via a calreticulin-associated mechanism.
Zhou J, Li X, Li N, Wang M, Sun G
Cellular signalling 2026 Jul;143:112479
Cellular signalling 2026 Jul;143:112479
λ-Carrageenan regulates antiviral responses by targeting classical NF-κB and IRF3-mediated signaling pathways.
Sun X, Yao W, Hu J, Zhang Y, Liu R, Hu W, Li Y, Wan B, Kong Z, Zhang G
International journal of biological macromolecules 2026 Jan;338(Pt 2):149760
International journal of biological macromolecules 2026 Jan;338(Pt 2):149760
Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification.
Starble RM, Sun EG, Gbyli R, Radda J, Lu J, Jensen TB, Sun N, Khudaverdyan N, Zhao T, Hu B, Melnick MA, Zhao S, Roper N, Wang GG, Tackett AJ, Wang Y, Song J, Politi K, Wang S, Xiao AZ
Nature structural & molecular biology 2026 Jan;33(1):7-19
Nature structural & molecular biology 2026 Jan;33(1):7-19
RADA16 and SAAP148 Peptide-Modified Collagen Self-Assembled Hydrogels for Accelerated Healing of Infected Wounds.
Liu Q, Wu J, Bei HP, Chen Y, Zhang Y, Peng X, Chen F, Zhao X, Chen Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(6):e19504
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(6):e19504
Reversal of diet-induced obesity by central insulin sensitizer FSTL1.
Li K, Dai H, Li K, Qiu S, Liu D, Wang C, Li S, Yang G, Li L, Li MD, Yang M
Neuron 2026 Jan 7;114(1):122-141.e5
Neuron 2026 Jan 7;114(1):122-141.e5
METTL1 interacts with XPO5 to modulate pre-miRNA export.
Cao Z, Chen X, Sun Y, Wang Y
Nucleic acids research 2026 Jan 22;54(3)
Nucleic acids research 2026 Jan 22;54(3)
Nuclear factor IC promoting porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppressing type I interferon transcription.
Shi X, Chen H, Xing Y, Wang K, Zhang X, Fan X, Zhang Y, Wang Y, Peng S, Wang A, Zhang G
BMC veterinary research 2026 Jan 2;22(1):80
BMC veterinary research 2026 Jan 2;22(1):80
CD48 is a novel immune checkpoint on tumour-associated macrophages in hepatocellular carcinoma.
Shi G, Xiao Y, Li Z, Qiu Y, Zhou Y, Zhang J, Li W, He L, Xie F, Cao H, Yu D, Du H, Li G, Zhang W, Wang S, Lei X, Zhang K, Zhang Y, Gao Y, Wang Z, Li M
Gut 2026 Jan 2;
Gut 2026 Jan 2;
Promoting the nuclear retention of HMGB1 attenuates astrocyte senescence.
Zhang N, Yang F, Shi J, Tang X, Fan A, Li W, Zhang F, Chai S, Chen Q, Wang C, Xu Y, Gong F, Lu Y, Zheng F
Journal of neuroinflammation 2026 Jan 12;23(1):55
Journal of neuroinflammation 2026 Jan 12;23(1):55
Lycium barbarum polysaccharide LBP3 alleviates 5-Fluorouracil-induced intestinal injury via a mechanism associated with activating Nrf2 and improving mitochondrial function.
Xie X, Cai Y, Xu R, Yang C, Li P, Zhu Y, Luo X, Zhou L, Wang Q
International immunopharmacology 2026 Jan 1;168(Pt 2):115879
International immunopharmacology 2026 Jan 1;168(Pt 2):115879
OTUD1 delays wound healing by regulating endothelial function and angiogenesis in diabetic mice.
Zhang J, Li W, Liu Y, Zheng J, Liu G, He M, Zheng Z, Zhu M, Cho N, Liang G, Han X, Ying H, Shi Q
Journal of advanced research 2026 Feb;80:1063-1081
Journal of advanced research 2026 Feb;80:1063-1081
Proteins Lamin A and SUN1 are exclusively decreased in nuclear grade 4 clear cell renal cell carcinoma.
Shibanuma R, Kobayashi S, Konno M, Kaneko R, Nishijima Y, Ikota H, Nomura M, Suzuki K, Yokoo H, Saio M
Oncology letters 2026 Feb;31(2):86
Oncology letters 2026 Feb;31(2):86
BAP1 Loss Induces Senescence and Enhances the Response to Radiation Therapy and Senolytics.
Elsayed AM, Mosbeh A, Eltasawi EG, Hanpude P, Uddin MN, Cebulla CM, Abdel-Rahman MH
bioRxiv : the preprint server for biology 2026 Feb 9;
bioRxiv : the preprint server for biology 2026 Feb 9;
Development of DOT1L-Targeted Protein Degraders for Treating MLL-r Leukemia.
Quan S, Unno K, Gupta DG, Yang W, Guo Q, Dufficy MF, Kerber MM, Elmashae AA, Pan H, Zhu JL, Schiltz GE, Abdulkadir SA
Journal of medicinal chemistry 2026 Feb 26;69(4):4439-4468
Journal of medicinal chemistry 2026 Feb 26;69(4):4439-4468
ANGPTL8 regulates glucose metabolism in gestational diabetes mellitus mice, and proteomic analysis reveals the PI3K/Akt pathway plays its role in insulin-resistance HepG(2) cells.
Xie X, Yan J, Chen X, He L, Wu J, Lu L
BMC pregnancy and childbirth 2026 Feb 25;26(1)
BMC pregnancy and childbirth 2026 Feb 25;26(1)
PDHA1 enhances resistance to ferroptosis in anoikis-resistant prostate cancer by upregulating AIFM2.
Cong Y, Chen K, Ju Y, He Q, Liu C, Chen J, Lv F, Chen J, Li H, Chen L, Song Y
Cell death discovery 2026 Feb 23;12(1)
Cell death discovery 2026 Feb 23;12(1)
Cellular Senescence Drives Zinc Accumulation and Transporter Dysregulation in Intestinal Epithelial Cells.
Terrell KC, Choi S, Choi J, Choi S
bioRxiv : the preprint server for biology 2026 Feb 20;
bioRxiv : the preprint server for biology 2026 Feb 20;
Tet2 deficiency-induced expansion of monocyte-derived macrophages promotes liver fibrosis.
Feng J, Wu B, Li Y, Sun P, Liu Q, Xiao Q, Cai JB, Zheng Y, Chen H, Xu Y, Liu Y, Shi GM, Tan L, Shi YG
The Journal of experimental medicine 2026 Feb 2;223(2)
The Journal of experimental medicine 2026 Feb 2;223(2)
Investigating the impact and mechanism of Licochalcone B derivative CTG12 on NLRP3 inflammasome.
Bian S, Fang ZE, Wang L, Wang J, Dong M, Yang N, Wang J, Li L, Xu G
Cell communication and signaling : CCS 2026 Feb 18;24(1)
Cell communication and signaling : CCS 2026 Feb 18;24(1)
CBFA2T2: a novel H3K27 reader regulating metabolism and tumor growth.
He S, Ou Y, Jiao F, Feng J, Zhu P, Ma J, Xu N, Li H, Guo R
Molecular cancer 2026 Feb 17;25(1)
Molecular cancer 2026 Feb 17;25(1)
Mitochondrial DNA drives NLRP3-IL-1β axis activation in microglia by binding to NLRP3, leading to neurodegeneration in Parkinson's disease models.
Gan Q, Fu X, Zhou T, Fan N, Nan N, Wang Y, Yang Y, Gou S, Hu L, Zhou S
Cell death & disease 2026 Feb 10;17(1):213
Cell death & disease 2026 Feb 10;17(1):213
Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis.
Gong D, Chen X, Dong Z, Chen H, Liu Z
Renal failure 2026 Dec;48(1):2652103
Renal failure 2026 Dec;48(1):2652103
TDP-43 pathology triggers neuroinflammation and cognitive impairment by inducing microglial necroptosis.
Guo S, Jin H, Sun H, Huang S, Chen Y, Chang Y, Zhang Y, Ding L, Chen S, Fu C, Yin Y, Cheng W
EMBO molecular medicine 2026 Apr;18(4):1318-1341
EMBO molecular medicine 2026 Apr;18(4):1318-1341
Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage-Induced Mitochondrial Apoptosis and Parthanatos-Like Cell Death.
Fan H, Zhao H, Zhang P, Yu P, Ji Y, Chen G, Jin H, Liu Y, Liu J, Chen ZS, Lyu A, Liang X, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e11406
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e11406
Macrophages with ITIH4 overexpression attenuate inflammatory responses and regulate intestinal epithelial cells.
Li J, Zhao Z, Fei J, Zhang R, Pan L, Xiang Y, Hong L, Zhan Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Apr 17;75(1)
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Apr 17;75(1)
Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling.
Han W, Guan M, Liao B, Han X, Li K, Chen Q, Guo X, Niu Y, Zhu Y, Bai D
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2025;58:e14408
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2025;58:e14408
A comparative study of capacitation-mediated changes in whole mouse sperm proteome.
Hwang JY
Animal cells and systems 2025;29(1):556-569
Animal cells and systems 2025;29(1):556-569
Low-dose extracorporeal shock wave attenuates sepsis-related acute lung injury by targeting mitochondrial dysfunction and pyroptosis crosstalk in type II alveolar epithelial cells.
Guo J, Qu X, Ge R, Liu D, Liu J, Hui Q, Ye F, Chen Y, Wang C, Lv D, Tang L, Xia M, Zhang Q
Frontiers in immunology 2025;16:1637378
Frontiers in immunology 2025;16:1637378
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
Li H, Gao Y, Huang M, Zhang H, Wu Q, Huang Y, Ye X, Chen W
Frontiers in pharmacology 2025;16:1557681
Frontiers in pharmacology 2025;16:1557681
SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy.
Wang X, Hu G, Shao Y, Dong Z, Liu L, Wang Y, Xie Y, Yu N, Zhu C, Wei F, Jia Y, Wang Y, Cai Q
Theranostics 2025;15(13):6369-6386
Theranostics 2025;15(13):6369-6386
Aryl hydrocarbon receptor facilitates HSV-1 lytic infection by enhancing viral gene transcription and receptor expression.
Huang P, Pan X, Chen H, Lei M, Ma Y, Guo X, Xie J, Li J, Sun J, Hu Y, Shi J
Frontiers in cellular and infection microbiology 2025;15:1548038
Frontiers in cellular and infection microbiology 2025;15:1548038
Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease.
Guo X, Zhang S, Sun Q, Li H, Wang L
Frontiers in medicine 2025;12:1627412
Frontiers in medicine 2025;12:1627412
Genetic association and functional implications of AhR gene polymorphism on preeclampsia.
Jiang H, Meng H, Ma Y, Qian Y, Chen X, Luo L, Yang Y
Frontiers in cardiovascular medicine 2025;12:1567127
Frontiers in cardiovascular medicine 2025;12:1567127
MgSO(4) alleviates hippocampal neuroinflammation and BBB damage to resist CMS-induced depression.
Wang Q, Hu Y, Li F, Hu L, Zhang Y, Qiao Y, Tang C, Wang R
Frontiers in nutrition 2025;12:1470505
Frontiers in nutrition 2025;12:1470505
SENP1 promotes p27kip1 nuclear export though enhanced SUMOylation in cholangiocarcinoma leading to increased cell proliferation and chemoresistance.
Jiang K, Yang W, Huang J, Tan X, Liu Y, Tu S, Luo J
International journal of molecular medicine 2025 Sep;56(3)
International journal of molecular medicine 2025 Sep;56(3)
Glutaredoxin 1 enhances endothelial cell angiogenesis by reducing VEGFA S-glutathionylation and delays vascular endothelial cell senescence.
Li F, Cui X, Yan Y, Jing X, Bai C, He D, Wang L, Gao C, Li M, Feng R
Free radical biology & medicine 2025 Sep;237:515-529
Free radical biology & medicine 2025 Sep;237:515-529
KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity.
Li Y, Peng L, Zhou Y, You Y, Jiang J, Luo Y
Brain research bulletin 2025 Sep;229:111467
Brain research bulletin 2025 Sep;229:111467
The Extremely Low Mechanical Force Generated by Nano-Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons.
Falconieri A, Da Palmata L, Cappello V, Schmidt TJN, Folino P, Storti B, Bizzarri R, Raffa V
Small (Weinheim an der Bergstrasse, Germany) 2025 Sep;21(38):e2503011
Small (Weinheim an der Bergstrasse, Germany) 2025 Sep;21(38):e2503011
Protective Effects of Ganoderma Triterpenoids Supplementation Against Myocardial Injury in Exhaustion Exercise Mice via Regulation of the Keap1/Nrf2/HO-1 Pathway.
Li J, Zhang L, Qin G, Liu W, Xu X, Zhu J, Zhao S, Qiu T
Food science & nutrition 2025 Sep;13(9):e70937
Food science & nutrition 2025 Sep;13(9):e70937
Osimertinib resistance-based immune prognostic related gene signature in EGFR mutant lung adenocarcinoma, in which PSMD11 promotes tumor progression.
Bai Y, Xu H, Bao P, Gao Y, Sun J, Shen Y, Zhao J, Jiang T
Translational lung cancer research 2025 Sep 30;14(9):3720-3739
Translational lung cancer research 2025 Sep 30;14(9):3720-3739
Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow.
Yang B, Su J, Wu J, Wang Z, Hu J, Yang M, Lin Y, Jin M, Bai X, Yu B, Zhang X
Nature communications 2025 Sep 25;16(1):8409
Nature communications 2025 Sep 25;16(1):8409
Oxidative modulation of Piezo1 channels.
Novosolova N, Braidotti N, Patinen T, Laitinen T, Ciubotaru C, Huttunen KM, Levonen AL, Cojoc D, Giniatullin R, Malm T
Redox biology 2025 Oct;86:103797
Redox biology 2025 Oct;86:103797
Pretreatment with alendronate augments lipid A-induced IFN-β production via upregulation of cGAS expression.
Watanabe S, Kiyoura Y, Tamai R
Pharmacological reports : PR 2025 Oct;77(5):1389-1399
Pharmacological reports : PR 2025 Oct;77(5):1389-1399
Liquid-liquid phase separation of GPS2-LATS1 promotes colorectal cancer progression by reprogramming lipid metabolism.
Ren Y, Chen J, Zhan X, Sheng S, Zhong Y, Gu M, Liu X, Zhang L, Bao L, Si Y, Liu Y
Oncogene 2025 Oct;44(39):3741-3754
Oncogene 2025 Oct;44(39):3741-3754
MUC1-C auto-regulatory complex with EBNA1 is responsible for latent Epstein-Barr virus-associated gastric cancer progression.
Ozawa H, Wang Y, Withers HG, Haratake N, Nakashoji A, Bhattacharya A, Fushimi A, Kikutake C, Yamanoi K, White S, Wang K, Daimon T, Shigeta K, Fukuda K, Kawakubo H, Kitagawa Y, Long MD, Gewurz BE, Kufe D
Oncogene 2025 Oct;44(38):3609-3624
Oncogene 2025 Oct;44(38):3609-3624
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells.
McCreery KP, Stubb A, Stephens R, Fursova NA, Cook A, Kruse K, Michelbach A, Biggs LC, Keikhosravi A, Nykänen S, Pulkkanen R, Hydén-Granskog C, Zou J, Lackmann JW, Niessen CM, Vuoristo S, Miroshnikova YA, Wickström SA
Nature cell biology 2025 Oct;27(10):1757-1770
Nature cell biology 2025 Oct;27(10):1757-1770
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
Feng J, Miao H, Xiao Z, Xu L, Wang Y, Cao X, Wang J, Wu Z, Xia P, Liu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.
Yin L, Zhang Y, Zhang B, Zhang J, Xiong M, Jiang N, Xiao J, Gao H, Xiong W, Wang X, Wang F, Yuan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e06600
The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity.
Li W, Liao Y, Liu Z, Niu L, Huang J, Jia Y, Xu R, Guan S, Liang Z, Li Y, Wu H, Zhu S, Tan L, Yu F, Wang Z, Sun L, Zhao D, Kong W, Fu Y
Nature communications 2025 Oct 3;16(1):8826
Nature communications 2025 Oct 3;16(1):8826
HIV proviral transcription and infectivity are enhanced by neddylation.
Vaca CC, Hudson H, Clerc I, Song C, D'Aquila RT
Journal of virology 2025 Oct 23;99(10):e0096825
Journal of virology 2025 Oct 23;99(10):e0096825
Investigation of the material basis and mechanism of Qingfei Paidu granules in treating LPS-induced acute pneumonia using UPLC-Q-TOF-MS/MS, network pharmacology, molecular docking and experimental verification.
Ma Y, Zhao H, Ma R, Guo Q, Li H, Zhang Y, Wu X, Wang X
Journal of pharmaceutical and biomedical analysis 2025 Oct 15;264:116973
Journal of pharmaceutical and biomedical analysis 2025 Oct 15;264:116973
Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice.
Yao YX, Lu X, Li Z, Liao HY, Liu ZB, Zhao H, Wang H, Xu DX, Tan ZX
Toxicology and applied pharmacology 2025 Nov;504:117524
Toxicology and applied pharmacology 2025 Nov;504:117524
Deacetylase SIRT1 modulates antiviral innate immunity and autoimmune diseases.
Yu SS, Yu H, Geng S, Tang RC, Zhang A, Zhang Y, Sun XY, Zhang J
International journal of biological macromolecules 2025 Nov;329(Pt 2):147873
International journal of biological macromolecules 2025 Nov;329(Pt 2):147873
Targeting MTPN sensitizes pancreatic cancer of wild-type BRCA1/2 to Cisplatin-based chemotherapy.
Wang Z, Huang X, Bai T, Jin Y, Gong T, Wu W, Kouken B, Wang Q, Wang L
Cancer gene therapy 2025 Nov;32(11):1245-1258
Cancer gene therapy 2025 Nov;32(11):1245-1258
Obacunone ameliorates high-fat diet-induced MAFLD by regulating the PPARγ-FABP1/CD36 axis and the gut-liver crosstalk.
Wang X, Hong J, Liang R, Bao S, Li L, Wang J, Feng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157180
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157180
HuB serves as the central hub for connecting HuR-related mRNAs with translation machinery in inflammation.
Zhang J, Huang X, Tang Y, Zhong X, Wang J, Wei M, Han X, Ke Y, Ba X
Communications biology 2025 Nov 30;9(1):3
Communications biology 2025 Nov 30;9(1):3
Sestrin2 ameliorates LPS-induced cardiomyocyte injury by inhibiting ferroptosis via the Nrf2/HO-1 pathway.
Yang Y, Yang P, Zheng Z, Tian Q
European journal of medical research 2025 Nov 28;31(1):3
European journal of medical research 2025 Nov 28;31(1):3
Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling.
Zhan D, Xu L, Mu W, Jin B, Feng Z, Liu S, Wu C, Luo L, Li L
Cell reports 2025 Nov 25;44(11):116544
Cell reports 2025 Nov 25;44(11):116544
LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55-Mediated Signalling in Spinal Cord Injury.
Chen D, Liu S, Tu LY, Yang MM, Xu CW, Jiang Y, Yang H, Tai CX, Wang YN, Xie YY, Shen PP, Wang B
Cell proliferation 2025 Nov 16;:e70146
Cell proliferation 2025 Nov 16;:e70146
The VCPKMT-VCP-HDAC1 axis inhibits colorectal cancer by conferring sensitivity to ferroptosis.
Huang C, Lin J, Xu S, Lv Y, Chen J, Cao J, Xie D, Wang F
Cancer cell international 2025 Nov 14;25(1):404
Cancer cell international 2025 Nov 14;25(1):404
TERT's protective effect on trophoblast cells: Reducing mitochondrial ROS.
Tian Z, Wang X, Luan Y, Liu R
Reproductive toxicology (Elmsford, N.Y.) 2025 May;134:108899
Reproductive toxicology (Elmsford, N.Y.) 2025 May;134:108899
RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development.
Jiao F, Tang T, Wang B, He S, Zhang Y, Dong L, Xu B, Liu Y, Zhu P, Guo R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2416350
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2416350
Nuclear m(6)A modification regulates satellite transcription and chromosome segregation.
Huang C, Shu X, Zhou S, Mi Y, Bian H, Li T, Li T, Ying X, Cheng C, Liu D, Gao M, Wen Y, Ma Q, Wang F, Cao J, Wang J, Liu J
Nature chemical biology 2025 May 22;
Nature chemical biology 2025 May 22;
PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells.
Kamii M, Kamata R, Saito H, Yamamoto G, Mashima C, Yamauchi T, Nakao T, Sakae Y, Yamamori-Morita T, Nakai K, Hakozaki Y, Takenaka M, Okamoto A, Ohashi A
Scientific reports 2025 May 2;15(1):15458
Scientific reports 2025 May 2;15(1):15458
Vitamin C Inhibits Scale Drop Disease Virus Infectivity by Targeting Nrf2 to Reduce Ferroptosis.
Chen J, Fu Y, Weng S, He J, Dong C
Antioxidants (Basel, Switzerland) 2025 May 10;14(5)
Antioxidants (Basel, Switzerland) 2025 May 10;14(5)
ZBP1 senses splicing aberration through Z-RNA to promote cell death.
Yang ZH, Wu P, Zhang BX, Yang CR, Huang J, Wu L, Guo SH, Zhou Y, Mao Y, Yin Y, Wu X, Cheng P, Li B, Zhou R, Shen HM, Nie S, Cai ZY, Mo W
Molecular cell 2025 May 1;85(9):1775-1789.e5
Molecular cell 2025 May 1;85(9):1775-1789.e5
Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin-Driven TFEB Nuclear Translocation.
Wang P, Li J, Li CG, Zhou X, Chen X, Zhu M, Wang H
Clinical and experimental pharmacology & physiology 2025 Mar;52(3):e70010
Clinical and experimental pharmacology & physiology 2025 Mar;52(3):e70010
The potential role of the SIRT1-Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress.
Zheng Z, Zhang P, Fu Y, Jiang Y, Zhu J, Wang F, Li S, Zhang Z, Chang T, Li T, Zhang M, Ruan B, Wang X
Cell biology international 2025 Mar;49(3):262-276
Cell biology international 2025 Mar;49(3):262-276
METTL3-mediated m(6)A modification regulates muscle development by promoting TM4SF1 mRNA degradation in P-body via YTHDF2.
Ru W, Cheng J, Gao Y, Yang K, Qi A, Zhang X, Qi X, Lan X, Liu W, Huang B, Chen H
International journal of biological macromolecules 2025 Mar;295:139576
International journal of biological macromolecules 2025 Mar;295:139576
Beyond a ferroptosis inducer: erastin can suppress nutrient deprivation induced cell death in the intervertebral disc.
Jin J, Chen Y, Chen X, Zhang Z, Wu Y, Tian N, Wu A, Wang X, Shao Z, Zhou Y, Zhang X, Wu Y
The spine journal : official journal of the North American Spine Society 2025 Mar;25(3):597-608
The spine journal : official journal of the North American Spine Society 2025 Mar;25(3):597-608
Serum starvation induces cytosolic DNA trafficking via exosome and autophagy-lysosome pathway in microglia.
Zhou L, Wu Z, Yi X, Xie D, Wang J, Wu W
Biochimica et biophysica acta. Molecular cell research 2025 Mar;1872(3):119905
Biochimica et biophysica acta. Molecular cell research 2025 Mar;1872(3):119905
STAT1 mediates the pro-inflammatory role of GBP5 in colitis.
Li Y, Wang W, Zhu R, Zhu X, Sun M, Huang Y, Chen W, Gao S, Jiao N, Lin X, Ke J, Xu T, Hou L, Lan P, Zhu L
Communications biology 2025 Mar 7;8(1):385
Communications biology 2025 Mar 7;8(1):385
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness.
Cui B, Luo H, He B, Liu X, Lv D, Zhang X, Su K, Zheng S, Lu J, Wang C, Yang Y, Zhao Z, Liu X, Wang X, Zhao Y, Nie X, Jiang Y, Zhang Z, Liu C, Chen X, Cai A, Lv Z, Liu Z, An F, Zhang Y, Yan Q, Kelley KW, Xu G, Xu L, Liu Q, Peng F
Signal transduction and targeted therapy 2025 Mar 5;10(1):79
Signal transduction and targeted therapy 2025 Mar 5;10(1):79
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Fang X, Zhong Y, Zheng R, Wu Q, Liu Y, Zhang D, Wang Y, Ding W, Wang K, Zhong F, Lin K, Yao X, Hu Q, Li X, Xu G, Liu N, Nie J, Li D, Geng H, Guan Y
Science advances 2025 Mar 21;11(12):eadr8648
Science advances 2025 Mar 21;11(12):eadr8648
Growth Arrest-specific 1 Inhibits Keap1/Nrf2 Signaling Transduction in the Activation of the Ferroptosis Program in Retinal Müller Cells.
Dai R, Qian Y, Liu S, Zou X, Sun S, Sun Z
Frontiers in bioscience (Landmark edition) 2025 Mar 18;30(3):27954
Frontiers in bioscience (Landmark edition) 2025 Mar 18;30(3):27954
Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cells.
Wen B, Zheng HX, Heng JH, Tang Q, Deng DX, Zhang ZD, Liao LD, Xu LY, Li EM
Cell death & disease 2025 Mar 1;16(1):147
Cell death & disease 2025 Mar 1;16(1):147
A thermosensitive hydrogel with synergistic stromal targeting and antitumor immunity modulation for pancreatic cancer immunotherapy.
Zhao G, Guo F, Yan W, Qu Y, Yan C, Lv H, Li G, Zhao J, Xie H, Li Y, Tian T, Zhao Z
Materials today. Bio 2025 Jun;32:101882
Materials today. Bio 2025 Jun;32:101882
Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming.
Liu J, Wang Y, Qiao P, Ying Y, Lin S, Lu F, Gao C, Li M, Yang B, Zhou H
Antioxidants (Basel, Switzerland) 2025 Jun 24;14(7)
Antioxidants (Basel, Switzerland) 2025 Jun 24;14(7)
Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.
Wang F, Zhou L, Zhong Y, Cai Y, Meng X, Chen M, Mao R, Xiao X, Yi C, Guo Y, Xie H, Zhang Y, Li J
MedComm 2025 Jul;6(7):e70205
MedComm 2025 Jul;6(7):e70205
Oleanolic Acid Up-Regulated UGT1A1 and Antagonized Inflammation by Affecting the Binding of PXR and PKCα to HSP90α and SRC1.
Zhu S, Gu Q, Meng C, Liu J, Du X, Liao B, Liu F, Xia C
Phytotherapy research : PTR 2025 Jul;39(7):3167-3181
Phytotherapy research : PTR 2025 Jul;39(7):3167-3181
YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2.
Zhao X, Sun J, Chen F, Tang H, Zeng Y, Li L, Yu Q, Chen L, Hammad M, Xu X, Meng Z, Wang W, Liang G
Clinical and translational medicine 2025 Jul;15(7):e70420
Clinical and translational medicine 2025 Jul;15(7):e70420
Activation of toll-like receptor 2 promotes the expression of inflammatory mediators and cell proliferation of human polycystic kidney disease cells.
Zhang Y, Plansinis M, Peak S, Weber E, Wei A, Xu Y, Ross M, Leagjeld A, Wallace DP, Zhang Y
Cellular signalling 2025 Jul;131:111749
Cellular signalling 2025 Jul;131:111749
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Liu L, Ma Y, Jian Z, Liao B, Li Y, Lin L, Wang M, Chen J, Wei J, Yang M, Liu Y, Yuan Y, Wen J, Xiang L, Qi S, Jin X, Wang K
Cell reports 2025 Jul 22;44(7):115936
Cell reports 2025 Jul 22;44(7):115936
DHX9-mediated epigenetic silencing of BECN1 contributes to impaired autophagy and tumor progression in breast cancer via recruitment of HDAC5.
Li Z, Liu F, Li F, Zeng G, Wen X, Ding J, Zhou J
Cell death & disease 2025 Jul 14;16(1):524
Cell death & disease 2025 Jul 14;16(1):524
The highly conserved PIWI-interacting RNA CRAPIR antagonizes PA2G4-mediated NF110-NF45 disassembly to promote heart regeneration in mice.
Ma W, Chen H, Tian Y, Huang W, Ren Z, Li J, Ouyang Q, Hu Y, Wang X, Ji H, Liu X, Liu Y, Wang X, Liu Y, Tian Y, Li F, Yang B, Wang N, Cai B
Nature cardiovascular research 2025 Jan;4(1):102-118
Nature cardiovascular research 2025 Jan;4(1):102-118
NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL.
Li C, Li H, Men X, Wang Y, Kang X, Hu M, Su X, Wang S, Lu D, Shen S, Huang H, Deng X, Liu Y, Zhang L, Cai W, Wu A, Lu Z
CNS neuroscience & therapeutics 2025 Jan;31(1):e70140
CNS neuroscience & therapeutics 2025 Jan;31(1):e70140
CircRNA-RBAC induces cardiac repair by promoting ribosome biogenesis and cell cycle progression in cardiomyocytes.
Huang S, Wei G, Jia X, Tang Z, Chen Q, Li C, Yan W, Jin M, Li X, Chen Y, Zheng H, Chen G, Liao W, Liao Y, Wang Y, Li J, Bin J
International journal of biological macromolecules 2025 Jan;287:138406
International journal of biological macromolecules 2025 Jan;287:138406
LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction.
Fan L, Guo D, Zhu C, Gao C, Wang Y, Yin F, Liu M, Zhou Y, Wei T, Xiong X, Yu K, Le A
Free radical biology & medicine 2025 Jan;226:29-42
Free radical biology & medicine 2025 Jan;226:29-42
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome.
Li S, Liu H, Hu H, Ha E, Prasad P, Jenkins BC, Das US, Mukherjee S, Shishikura K, Hu R, Rader DJ, Pei L, Baur JA, Matthews ML, FitzGerald GA, McReynolds MR, Susztak K
Cell metabolism 2025 Jan 7;37(1):154-168.e7
Cell metabolism 2025 Jan 7;37(1):154-168.e7
Extract of Nanhaia speciosa J. Compton & Schrire alleviates LPS-induced acute lung injury via the NF-κB/Nrf2/AQPs pathway.
Zhou S, Hu Y, Liu L, Li L, Deng F, Mo L, Huang H, Liang Q
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118831
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118831
Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer.
Starble RM, Sun EG, Gbyli R, Radda J, Lu J, Jensen TB, Sun N, Khudaverdyan N, Hu B, Melnick MA, Zhao S, Roper N, Wang GG, Song J, Politi K, Wang S, Xiao AZ
bioRxiv : the preprint server for biology 2025 Jan 27;
bioRxiv : the preprint server for biology 2025 Jan 27;
Overexpression of Apolipoprotein A-I Alleviates Insulin Resistance in MASLD Mice Through the PPARα Pathway.
Wang Y, Zhang Y, Wang Y
International journal of molecular sciences 2025 Jan 26;26(3)
International journal of molecular sciences 2025 Jan 26;26(3)
ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure.
Liu Q, Liu D, Wang Y, Wei X, Ma W, Gu H, Jia S, He Y, Luo W, Cao S, Yang Z, Wu A, Yuan Z
Cell death & disease 2025 Jan 19;16(1):29
Cell death & disease 2025 Jan 19;16(1):29
Spatial regulation of NSUN2-mediated tRNA m5C installation in cognitive function.
Gonskikh Y, Tirrito C, Bommisetti P, Mendoza-Figueroa MS, Stoute J, Kim J, Wang Q, Song Y, Liu KF
Nucleic acids research 2025 Jan 11;53(2)
Nucleic acids research 2025 Jan 11;53(2)
Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4.
Medina-Suárez D, Han L, O'Reilly S, Liu J, Wei C, Brenière M, Goff NJ, Chen C, Modesti M, Meek K, Harrington B, Yu K
Nucleic acids research 2025 Jan 11;53(2)
Nucleic acids research 2025 Jan 11;53(2)
Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome.
Yao Q, Wen J, Chen S, Wang Y, Wen X, Wang X, Li C, Zheng C, Li J, Ma Z, Zhan X, Xiao X, Bai Z
Journal of ethnopharmacology 2025 Jan 10;336:118661
Journal of ethnopharmacology 2025 Jan 10;336:118661
CCAAT/Enhancer-Binding Protein Beta Nitration Participates in Hyperhomocysteinemia-Induced Cardiomyocyte Autophagic Flux Blockage by Inhibiting Transcription Factor EB Transcription.
Chai J, Xu J, Zhang S, Yan W, Chen S, Zhu X, Luo C, Wang W
Antioxidants & redox signaling 2025 Feb;42(4-6):165-183
Antioxidants & redox signaling 2025 Feb;42(4-6):165-183
Targeting CDK2 Confers Vulnerability to Lenvatinib Via Driving Senescence in Anaplastic Thyroid Cancer.
Ma B, Sang Y, Du X, Zhang Y, Yin M, Xu W, Liu W, Lu J, Guan Q, Wang Y, Liao T, Wang Y, Xiang J, Shi R, Qu N, Ji Q, Zhang J, Ji D, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2413514
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2413514
Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors.
Wang W, Xing J, Zhang X, Liu H, Liu X, Jiang H, Xu C, Zhao X, Hu Z
eLife 2025 Feb 26;13
eLife 2025 Feb 26;13
Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression.
Cao YF, Wang H, Sun Y, Tong BB, Shi WQ, Peng L, Zhang YM, Wu YQ, Fu T, Zou HY, Zhang K, Xu LY, Li EM
Nature communications 2025 Feb 2;16(1):1271
Nature communications 2025 Feb 2;16(1):1271
Targeting the NLRP3 in macrophages contributes to senescence cell clearance in radiation-induced skin injury.
Liu G, Chen Y, Dai S, Wu G, Wang F, Chen W, Wu L, Luo P, Shi C
Journal of translational medicine 2025 Feb 18;23(1):196
Journal of translational medicine 2025 Feb 18;23(1):196
Nucleolar ribosomal RNA synthesis continues in differentiating lens fiber cells until abrupt nuclear degradation required for ocular lens transparency.
Rayêe D, Meier UT, Eliscovich C, Cvekl A
RNA biology 2025 Dec;22(1):1-16
RNA biology 2025 Dec;22(1):1-16
Nuclear factor IX could facilitate porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppresses retinoic acid-inducible gene I (RIG-I) and toll-like receptor 3 (TLR-3)-mediated type I interferon transcription.
Shi X, Xing Y, Chen H, Wang K, Zhang X, Fan X, Zhang Y, Wang Y, Peng S, Wang A, Zhang G
Microbial pathogenesis 2025 Dec;209:108102
Microbial pathogenesis 2025 Dec;209:108102
Indole modulates lipoteichoic acid-induced inflammatory response in duck intestinal epithelial cells.
Yan W, Zhu A, Zhong B, Chen Q
Microbial pathogenesis 2025 Dec;209:108030
Microbial pathogenesis 2025 Dec;209:108030
Single-Cell and Spatial Transcriptomics-Based Research Reveals Association Between M2a Macrophages and Tumor Spread through Air Spaces in Lung Adenocarcinoma.
Ding Y, Zhang H, Wen H, Zhao S, Li J, Liu X, Wang K, Huang Y, Xu M, Sun D
The American journal of pathology 2025 Dec;195(12):2477-2491
The American journal of pathology 2025 Dec;195(12):2477-2491
Genetic and functional analysis of ZMIZ1 in neurodevelopmental disorder with dysmorphic facies and distal skeletal anomalies (NEDDFSA): insights from muscle cells and signaling pathways.
Li S, Zhou D, Han Y, Feng C, Lv X, Fu G, Wei X, Wu C, Yu C, Yang Z
Pediatric research 2025 Dec 7;
Pediatric research 2025 Dec 7;
Multi-omics analysis reveals that ALYREF-mediated m(5)C modification promotes platinum resistance in ovarian cancer via the NSUN2/ALYREF/LGR4 axis.
Yang S, He P, Wang W, Xu X, Xi X, Li Y
Cell death & disease 2025 Dec 5;17(1):77
Cell death & disease 2025 Dec 5;17(1):77
Targeting TRIM59 impairs RNA splicing and promotes neuroblastoma differentiation and therapeutic responses.
Zhang Y, Yang Y, Chen G, Yin M, Gao Y, Li Y, Feng H
Journal of experimental & clinical cancer research : CR 2025 Dec 18;45(1):25
Journal of experimental & clinical cancer research : CR 2025 Dec 18;45(1):25
Targeting KRAS Inhibitor-Resistant Pancreatic Cancer with an MUC1-C Antibody-Drug Conjugate.
Ozawa H, Takahashi K, Motegi T, Jacobi J, Bhattarchya A, Shigeta K, Takamori S, Onishi M, Luan Z, Fukuda K, Ueno A, Kitago M, Kawakubo H, Kitagawa Y, Keith D, Muschler J, Sears RC, Long MD, Mancias JD, Aguirre AJ, Kufe D
Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Dec 15;31(24):5246-5260
Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Dec 15;31(24):5246-5260
A SETD2-CDK1-lamin axis maintains nuclear morphology and genome stability.
Khan A, Zhang C, Nguyen PG, Metts JM, Collins LC, Jain K, Mills CA, Vlach L, Li K, Brademeyer AL, Bowman BM, Major MB, Aubé J, Herring LE, Rathmell WK, Mason FM, Davis IJ, Zhang Q, Strahl BD
Nature cell biology 2025 Aug;27(8):1327-1341
Nature cell biology 2025 Aug;27(8):1327-1341
DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy.
Ding R, Huang W, Shen C, Pan Y, Zhong Y, Kong B, Shen Y, Xiang M, Ye B
Aging cell 2025 Aug;24(8):e70099
Aging cell 2025 Aug;24(8):e70099
Sigma-1R-Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS.
Lin CY, Wu HC, Fu RH, Weng EF, Hsieh WC, Su TP, Wu HE, Wang SM
Neurobiology of disease 2025 Aug;212:106992
Neurobiology of disease 2025 Aug;212:106992
Dehydroabietic acid protects against cerebral ischaemia-reperfusion injury by modulating microglia-mediated neuroinflammation via targeting PKCδ.
Li L, Tang H, She L, Lin Z, Yu Q, Zeng Y, Chen L, Chen F, Liang G, Zhao X, Cho N, Wang Y
British journal of pharmacology 2025 Aug;182(16):3818-3837
British journal of pharmacology 2025 Aug;182(16):3818-3837
Downregulated TFPI2 Accelerates Skin Aging by Repressing the Cell Cycle through Phosphoinositide 3-Kinase/Protein Kinase B/CDC6 Pathway.
Wang F, Yi C, Zhong Y, Zhou L, Meng X, Mao R, Guo Y, Xie H, Zhang Y, Huang Y, Li J
The Journal of investigative dermatology 2025 Aug;145(8):1910-1920.e7
The Journal of investigative dermatology 2025 Aug;145(8):1910-1920.e7
Oncogenic GOPC-ROS1 fusion promotes the formation of lymphatic malformations by impairing tight junction and its crizotinib resistance through repressing ferroptosis.
Tian R, Weng Z, Liang H, Zhang C, He Q, Li J, Zhang R, Yin X, Deng D, Hong L, Gu S, Zhan Z
Biochemical pharmacology 2025 Aug 15;242(Pt 1):117243
Biochemical pharmacology 2025 Aug 15;242(Pt 1):117243
Artemisia annua L. leaf extracts suppress influenza virus infection by targeting the viral nucleoprotein and blocking mitochondria-mediated apoptosis.
Zhao X, Dai X, Wang F, Li C, Song X, Han Y, Zhang C, Wang L, He Z, Zhang R, Ye L
Virologica Sinica 2025 Apr;40(2):247-259
Virologica Sinica 2025 Apr;40(2):247-259
The OLR1/NF-κB feedback loop exacerbates HIV-1 Tat-induced microglial inflammatory response and neuronal apoptosis.
Zhang Q, Tao W, Wang J, Qian M, Zhou M, Gao L
Journal of neurovirology 2025 Apr;31(2):170-186
Journal of neurovirology 2025 Apr;31(2):170-186
3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury.
Liu C, Wang Y, Sheng L, Zhang Y, Luo G, Ruan XZ, Chen Y, Huang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156445
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156445
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.
He X, Li Y, Li J, Li Y, Chen S, Yan X, Xie Z, Du J, Chen G, Song J, Mei Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413121
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413121
Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer.
Liang X, Tian R, Li T, Wang H, Qin Y, Qian M, Fan J, Wang D, Cui HY, Jiang J
Cell death discovery 2025 Apr 4;11(1):139
Cell death discovery 2025 Apr 4;11(1):139
MUC1-C dependency in drug resistant HR+/HER2- breast cancer identifies a new target for antibody-drug conjugate treatment.
Nakashoji A, Bhattacharya A, Ozawa H, Haratake N, Shigeta K, Fushimi A, Yamashita N, Matsui A, Kure S, Kameyama T, Takeuchi M, Fukuda K, Yokoe T, Nagayama A, Hayahsida T, Kitagawa Y, Liu R, Giordano A, Jeselsohn R, Shapiro GI, Kufe D
NPJ breast cancer 2025 Apr 26;11(1):39
NPJ breast cancer 2025 Apr 26;11(1):39
EMG1 methyltransferase activity affects ribosome occupancy at KSHV uORFs.
Harrington EM, Murphy JC, Harper KL, Hayward C, Mottram TJ, Aspden JL, Whitehouse A
Cell reports 2025 Apr 22;44(4):115516
Cell reports 2025 Apr 22;44(4):115516
Decursin induces FLT3-ITD acute myeloid leukemia cell apoptosis by increasing the expression of the ubiquitin-conjugase UBE2L6.
Zhang T, Li Y, Liao W, Mou Y, Zhan X, Hu Q, Zhao Z, Xiong D
Cell communication and signaling : CCS 2025 Apr 2;23(1):162
Cell communication and signaling : CCS 2025 Apr 2;23(1):162
IP6K1 Rewires LKB1 Signaling to Mediate Hyperglycemic Endothelial Senescence.
Xing C, Shi L, Zhu L, Aguirre T, Qi J, Chen Y, Liu Y, Chin AC, Zhu H, Fiedler D, Chen AF, Fu C
Diabetes 2025 Apr 1;74(4):486-501
Diabetes 2025 Apr 1;74(4):486-501
Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis.
Chen N, Xu X, Guo Y, Zhao M, Li Y, Zhou T, Zhang X, Gao J, Zhu F, Guo C, Shi Y, Wang Q, Wu W, Zhang L, Li Y
Research (Washington, D.C.) 2024;7:0400
Research (Washington, D.C.) 2024;7:0400
Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway.
Gong D, Dong Z, Chen X, Chen H, Lin H
Acta cirurgica brasileira 2024;39:e396124
Acta cirurgica brasileira 2024;39:e396124
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Zhao J, Chen C, Ge L, Jiang Z, Hu Z, Yin L
Frontiers in immunology 2024;15:1386780
Frontiers in immunology 2024;15:1386780
Celastrol alleviates diabetic vascular injury via Keap1/Nrf2-mediated anti-inflammation.
An N, Wang R, Li L, Wang B, Wang H, Peng G, Zhou H, Chen G
Frontiers in pharmacology 2024;15:1360177
Frontiers in pharmacology 2024;15:1360177
NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway.
Sun X, Dong M, Li J, Sun Y, Gao Y, Wang Y, Du L, Liu Y, Ji K, He N, Wang J, Zhang M, Song H, Xu C, Liu Q
Theranostics 2024;14(2):681-698
Theranostics 2024;14(2):681-698
A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4.
Yong Y, Yan L, Wei J, Feng C, Yu L, Wu J, Guo M, Fan D, Yu C, Qin D, Zhou X, Wu A
Theranostics 2024;14(16):6161-6184
Theranostics 2024;14(16):6161-6184
DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.
Shokrollahi M, Stanic M, Hundal A, Chan JNY, Urman D, Jordan CA, Hakem A, Espin R, Hao J, Krishnan R, Maass PG, Dickson BC, Hande MP, Pujana MA, Hakem R, Mekhail K
Nature structural & molecular biology 2024 Sep;31(9):1319-1330
Nature structural & molecular biology 2024 Sep;31(9):1319-1330
Isoquercetin Ameliorates Osteoarthritis via Nrf2/NF-κB Axis: An In Vitro and In Vivo Study.
Yu H, Lou J, Ni L, Yan M, Zhu K, Mao S, Zhu J
Chemical biology & drug design 2024 Sep;104(3):e14620
Chemical biology & drug design 2024 Sep;104(3):e14620
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells.
McCreery KP, Stubb A, Stephens R, Fursova NA, Cook A, Kruse K, Michelbach A, Biggs LC, Keikhosravi A, Nykänen S, Hydén-Granskog C, Zou J, Lackmann JW, Niessen CM, Vuoristo S, Miroshnikova YA, Wickström SA
bioRxiv : the preprint server for biology 2024 Sep 7;
bioRxiv : the preprint server for biology 2024 Sep 7;
Phospholipase D3 regulates TFEB/TFE3 metabolism to maintain lysosomal homeostasis.
Wang Y, Rieschick P, Romero-Fernandez W, Appelbaum N, Carvajal-Tapia C, Shostak A, Schrag M
bioRxiv : the preprint server for biology 2024 Sep 26;
bioRxiv : the preprint server for biology 2024 Sep 26;
Nuclear translocation of nucleotide enzyme Phosphoglucomutase 2 governs DNA damage response and anti-tumor immunity.
Lyu Y, Liu C, Lin H, Song H, Zhuang Q, Hu A, Chen L, Yang H, Mao Y
Heliyon 2024 Sep 15;10(17):e36415
Heliyon 2024 Sep 15;10(17):e36415
Apo-12'-capsorubinal exhibits anti-inflammatory effects and activates nuclear factor erythroid 2-related factor 2 in RAW264.7 macrophages.
Takatani N, Miyafusa H, Yamano Y, Beppu F, Hosokawa M
Archives of biochemistry and biophysics 2024 Oct;760:110125
Archives of biochemistry and biophysics 2024 Oct;760:110125
CHAC1 blockade suppresses progression of lung adenocarcinoma by interfering with glucose metabolism via hijacking PKM2 nuclear translocation.
Pan J, Wu S, Pan Q, Zhang Y, He L, Yao Q, Chen J, Li J, Xu Y
Cell death & disease 2024 Oct 5;15(10):728
Cell death & disease 2024 Oct 5;15(10):728
Neurons enhance blood-brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion.
Yang L, Lin Z, Mu R, Wu W, Zhi H, Liu X, Yang H, Liu L
eLife 2024 Oct 30;13
eLife 2024 Oct 30;13
Continuous nucleolar ribosomal RNA synthesis in differentiating lens fiber cells until abrupt nuclear degradation required for ocular lens transparency.
Rayêe D, Meier UT, Eliscovich C, Cvekl A
bioRxiv : the preprint server for biology 2024 Oct 22;
bioRxiv : the preprint server for biology 2024 Oct 22;
Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells.
Lazarchuk P, Nguyen MM, Curca CM, Pavlova MN, Oshima J, Sidorova JM
Aging 2024 Oct 17;16(20):12977-13011
Aging 2024 Oct 17;16(20):12977-13011
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.
Wang S, Cheng T, Chen X, Zeng C, Qin W, Xu Y
Clinical science (London, England : 1979) 2024 Oct 16;138(20):1287-1304
Clinical science (London, England : 1979) 2024 Oct 16;138(20):1287-1304
Spinster homolog 2 (SPNS2) deficiency drives endothelial cell senescence and vascular aging via promoting pyruvate metabolism mediated mitochondrial dysfunction.
Tang H, Gao P, Peng W, Wang X, Wang Z, Deng W, Yin K, Zhu X
Cell communication and signaling : CCS 2024 Oct 11;22(1):492
Cell communication and signaling : CCS 2024 Oct 11;22(1):492
Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer.
Wu H, Sun C, Cao W, Teng Q, Ma X, Schiöth HB, Dong R, Zhang Q, Kong B
Cancer letters 2024 Oct 10;602:217192
Cancer letters 2024 Oct 10;602:217192
SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8(+) T cell activation.
Liu W, You D, Lin J, Zou H, Zhang L, Luo S, Yuan Y, Wang Z, Qi J, Wang W, Ye X, Yang X, Deng Y, Teng F, Zheng X, Lin Y, Huang Z, Huang Y, Yang Z, Zhou X, Zhang Y, Chen R, Xu L, Li J, Yang W, Zhang H
Cell metabolism 2024 Oct 1;36(10):2245-2261.e6
Cell metabolism 2024 Oct 1;36(10):2245-2261.e6
Stress granules are not present in Kras mutant cancers and do not control tumor growth.
Libert M, Quiquempoix S, Fain JS, Pyr Dit Ruys S, Haidar M, Wulleman M, Herinckx G, Vertommen D, Bouchart C, Arsenijevic T, Van Laethem JL, Jacquemin P
EMBO reports 2024 Nov;25(11):4693-4707
EMBO reports 2024 Nov;25(11):4693-4707
Nup210 Promotes Colorectal Cancer Progression by Regulating Nuclear Plasma Transport.
Han F, Fan X, Hu M, Wen J, Wang J, Zhang D, Wang S, Ding Y, Ye Y, Jiao H
Laboratory investigation; a journal of technical methods and pathology 2024 Nov;104(11):102149
Laboratory investigation; a journal of technical methods and pathology 2024 Nov;104(11):102149
The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik JO, Chen YM, Raybuck AL, Billadeau DD, Shapiro VS, Springer W, Sun J, Boothby MR, Zeng H
Nature communications 2024 Nov 23;15(1):10163
Nature communications 2024 Nov 23;15(1):10163
Optimized simple culture protocol for inducing mature myotubes from MYOD1-overexpressed human iPS cells.
Wada E, Susumu N, Okuzaki Y, Hotta A, Sakurai H, Hayashi YK
Scientific reports 2024 Nov 20;14(1):28783
Scientific reports 2024 Nov 20;14(1):28783
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
Liu J, Gao L, Zhou N, Jiang Z, Che S, Deng Y, Zang N, Ren L, Xie X, Xie J, Liu E
Virology 2024 May;593:110018
Virology 2024 May;593:110018
UBC9-mediated SUMOylation of Lamin B1 enhances DNA-damage-induced nuclear DNA leakage and autophagy after spinal cord injury.
Fan YP, Lou JS, Jin MR, Zhou CH, Shen HH, Fu CY, Mao XJ, Chen YY, Zhong JJ, Wang LL, Wu JS
Journal of cellular physiology 2024 May;239(5):e31213
Journal of cellular physiology 2024 May;239(5):e31213
Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover.
Foo MXR, Ong PF, Yap ZX, Maric M, Bong CJS, Dröge P, Burke B, Dreesen O
Aging cell 2024 May;23(5):e14105
Aging cell 2024 May;23(5):e14105
A mixture of extracts from natural ingredients reduces the neurotoxic polarization of microglia via modulating NF-κB/NF-E2-related factor 2 activation.
Gui S, Ni J, Mizutani S, Shigematsu N, Nakanishi H, Kashiwazaki H, Wu Z
Food science & nutrition 2024 May;12(5):3745-3758
Food science & nutrition 2024 May;12(5):3745-3758
Peripherally targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels.
Shin SM, Itson-Zoske B, Fan F, Xiao Y, Qiu C, Cummins TR, Hogan QH, Yu H
The Journal of clinical investigation 2024 May 9;134(13)
The Journal of clinical investigation 2024 May 9;134(13)
IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA viruses.
Cruz-Rivera PC, Eitson JL, Schoggins JW
bioRxiv : the preprint server for biology 2024 May 5;
bioRxiv : the preprint server for biology 2024 May 5;
LncRNA-LncDACH1 mediated phenotypic switching of smooth muscle cells during neointimal hyperplasia in male arteriovenous fistulas.
Li Z, Zhao Y, Pan Z, Cai B, Zhang C, Jiao J
Nature communications 2024 May 3;15(1):3743
Nature communications 2024 May 3;15(1):3743
EZH2 inhibition induces senescence via ERK1/2 signaling pathway in multiple myeloma.
Guo S, Tang Q, Gao X, Hu L, Hu K, Zhang H, Zhang Q, Lai Y, Liu Y, Wang Z, Chang S, Zhang Y, Hu H, An D, Peng Y, Cai H, Shi J
Acta biochimica et biophysica Sinica 2024 May 27;56(7):1055-1064
Acta biochimica et biophysica Sinica 2024 May 27;56(7):1055-1064
Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
Wang D, Li Y, Yang H, Shen X, Shi X, Li C, Zhang Y, Liu X, Jiang B, Zhu X, Zhang H, Li X, Bai H, Yang Q, Gao W, Bai F, Ji Y, Chen Q, Ben J
Nature communications 2024 May 21;15(1):4340
Nature communications 2024 May 21;15(1):4340
Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases.
Tanaka M, Shirakura K, Takayama Y, Μatsui M, Watanabe Y, Yamamoto T, Takahashi J, Tanaka S, Hino N, Doi T, Obana M, Fujio Y, Takayama K, Okada Y
Communications biology 2024 May 18;7(1):599
Communications biology 2024 May 18;7(1):599
Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis.
Li H, Ni H, Li Y, Zhou A, Qin X, Li Y, Che L, Mo H, Qin C, Li J
Cell death discovery 2024 May 13;10(1):227
Cell death discovery 2024 May 13;10(1):227
Macrophage SHP2 Deficiency Alleviates Diabetic Nephropathy via Suppression of MAPK/NF-κB- Dependent Inflammation.
Han X, Wei J, Zheng R, Tu Y, Wang M, Chen L, Xu Z, Zheng L, Zheng C, Shi Q, Ying H, Liang G
Diabetes 2024 May 1;73(5):780-796
Diabetes 2024 May 1;73(5):780-796
Hydrogen exerts neuroprotective effects after subarachnoid hemorrhage by attenuating neuronal ferroptosis and inhibiting neuroinflammation.
Peng Z, Li XJ, Zhou Y, Zhang JT, Zhu Q, Sun JQ, Hang CH, Li W, Zhang QR, Zhuang Z
Free radical biology & medicine 2024 Mar;215:79-93
Free radical biology & medicine 2024 Mar;215:79-93
RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
He S, Lu M, Zhang L, Wang Z
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166996
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):166996
EGLN3 attenuates gastric cancer cell malignant characteristics by inhibiting JMJD8/NF-κB signalling activation independent of hydroxylase activity.
Cai F, Yang X, Ma G, Wang P, Zhang M, Zhang N, Zhang R, Liang H, Nie Y, Dong C, Deng J
British journal of cancer 2024 Mar;130(4):597-612
British journal of cancer 2024 Mar;130(4):597-612
Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
Ma H, Suleman M, Zhang F, Cao T, Wen S, Sun D, Chen L, Jiang B, Wang Y, Lin F, Wang J, Li B, Li Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2301476
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2301476
Rag-GTPase-TFEB/TFE3 axis controls B cell mitochondrial fitness and humoral immunity independent of mTORC1.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik JO, Chen YM, Raybuck AL, Billadeau D, Shapiro V, Springer W, Sun J, Boothby MR, Zeng H
Research square 2024 Mar 29;
Research square 2024 Mar 29;
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging.
Zhou Z, Yao J, Wu D, Huang X, Wang Y, Li X, Lu Q, Qiu Y
Immunity 2024 Mar 12;57(3):513-527.e6
Immunity 2024 Mar 12;57(3):513-527.e6
The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik JO, Chen YM, Raybuck AL, Billadeau D, Shapiro V, Springer W, Sun J, Boothby MR, Zeng H
bioRxiv : the preprint server for biology 2024 Mar 12;
bioRxiv : the preprint server for biology 2024 Mar 12;
IL-35 ameliorates lipopolysaccharide-induced endothelial dysfunction by inhibiting endothelial-to-mesenchymal transition.
Feng J, Li K, Xie F, Han L, Wu Y
International immunopharmacology 2024 Mar 10;129:111567
International immunopharmacology 2024 Mar 10;129:111567
Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity.
Feng S, Wang D, Jin Y, Huang S, Liang T, Sun W, Du X, Zhuo L, Shan C, Zhang W, Jing T, Zhao S, Hong R, You L, Liu G, Chen L, Ye D, Li X, Yang Y
Cell reports 2024 Jun 25;43(6):114300
Cell reports 2024 Jun 25;43(6):114300
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
Xu S, Wang N, Zuccaro MV, Gerhardt J, Iyyappan R, Scatolin GN, Jiang Z, Baslan T, Koren A, Egli D
Nature communications 2024 Jun 19;15(1):5247
Nature communications 2024 Jun 19;15(1):5247
Vagal-α7 nicotinic acetylcholine receptor signaling exacerbates influenza severity by promoting lung epithelial cell infection.
Zhao C, Pan M, Chen J, Li L, Zhang Y, Liu W, Matthay MA, Wang H, Jin X, Xu JF, Su X
Journal of medical virology 2024 Jul;96(7):e29768
Journal of medical virology 2024 Jul;96(7):e29768
Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies.
Ye Z, Ge Z, Yang S, Hu T, Ye Q, Chen H
Phytotherapy research : PTR 2024 Jul;38(7):3509-3524
Phytotherapy research : PTR 2024 Jul;38(7):3509-3524
New compatible pair of TCM: Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation.
Xu Y, Wang X, Wang Y, Guo L, Zhao X, Dong M, Wen J, Wu Z, Li C, Mu W, Guo Y, Bai Z, Xiao X
Heliyon 2024 Jul 30;10(14):e34591
Heliyon 2024 Jul 30;10(14):e34591
NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancer.
Cao L, Lin G, Fan D, Weng K, Chen Y, Wang J, Li P, Zheng C, Huang C, Xie J
Cell reports 2024 Jul 23;43(7):114446
Cell reports 2024 Jul 23;43(7):114446
CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1.
Mei S, Ma X, Zhou L, Wuyun Q, Wang J, Xiao Q, Wang M, Zhang K, Chen C, Yan J, Ding H
iScience 2024 Jul 19;27(7):110200
iScience 2024 Jul 19;27(7):110200
Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis.
Xu Z, Li J, Zhou K, Wang K, Hu H, Hu Y, Gao Y, Luo Z, Huang J
Journal of ethnopharmacology 2024 Jul 15;329:118162
Journal of ethnopharmacology 2024 Jul 15;329:118162
SMYD5 is a regulator of the mild hypothermia response.
Rafnsdottir S, Jang K, Halldorsdottir ST, Vinod M, Tomasdottir A, Möller K, Halldorsdottir K, Reynisdottir T, Atladottir LH, Allison KE, Ostacolo K, He J, Zhang L, Northington FJ, Magnusdottir E, Chavez-Valdez R, Anderson KJ, Bjornsson HT
bioRxiv : the preprint server for biology 2024 Jul 12;
bioRxiv : the preprint server for biology 2024 Jul 12;
Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei.
Villagomez FR, Lang J, Rosario FJ, Nunez-Avellaneda D, Webb P, Neville M, Woodruff ER, Bitler BG
Cancer research communications 2024 Jul 1;4(7):1625-1642
Cancer research communications 2024 Jul 1;4(7):1625-1642
Cysteine and glycine-rich protein 2 retards platelet-derived growth factor-BB-evoked phenotypic transition of airway smooth muscle cells by decreasing YAP/TAZ activity.
Wang H, Zhang Y, Zhong B, Geng Y, Hao J, Jin Q, Hou W
Cell biochemistry and function 2024 Jan;42(1):e3896
Cell biochemistry and function 2024 Jan;42(1):e3896
Dectin1 contributes to hypertensive vascular injury by promoting macrophage infiltration through activating the Syk/NF-κB pathway.
Zhang J, Tu Y, Wei J, Zheng R, Shao J, Chen Q, Liang G, Ying H, Han X, Shi Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166911
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166911
Unveiling the immunomodulatory mechanism of polysaccharides from Polygonum cyrtonema based on RNA-seq.
Shan J, Ma W, Guo Y, Chang X, Xie J, Chen Y, Hu X, Yu Q
Food research international (Ottawa, Ont.) 2024 Jan;175:113755
Food research international (Ottawa, Ont.) 2024 Jan;175:113755
Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT/GSK3β/NRF2/GPX4 axis.
Huang W, Wen F, Yang P, Li Y, Li Q, Shu P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155220
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155220
Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases.
Fang ZE, Wang Y, Bian S, Qin S, Zhao H, Wen J, Liu T, Ren L, Li Q, Shi W, Zhao J, Yang H, Peng R, Wang Q, Bai Z, Xu G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155159
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155159
Protective effects of sodium humate on the intestinal barrier damage of Salmonella Typhimurium-challenged broilers.
Ma W, Zou X, Sun X, Wang W, Liu K, He Y, Liu Y, Wang D
Animal science journal = Nihon chikusan Gakkaiho 2024 Jan-Dec;95(1):e14004
Animal science journal = Nihon chikusan Gakkaiho 2024 Jan-Dec;95(1):e14004
Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells.
Xie L, Li R, Zhang J, Li H, Gao X, Zhang M
Journal of agricultural and food chemistry 2024 Jan 31;72(4):2135-2144
Journal of agricultural and food chemistry 2024 Jan 31;72(4):2135-2144
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Wang R, Zeng J, Chen L, Sun L, Wang Y, Xu J, He X
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development.
Mak S, Hammes A
International journal of molecular sciences 2024 Jan 24;25(3)
International journal of molecular sciences 2024 Jan 24;25(3)
FOXP3(+) regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity.
Liu X, Zhang W, Han Y, Cheng H, Liu Q, Ke S, Zhu F, Lu Y, Dai X, Wang C, Huang G, Su B, Zou Q, Li H, Zhao W, Xiao L, Lu L, Tong X, Pan F, Li H, Li B
Nature communications 2024 Jan 2;15(1):122
Nature communications 2024 Jan 2;15(1):122
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
Xu Y, Liu X, Zeng W, Zhu Y, Dong J, Wu F, Chen C, Sharma S, Lin Y
Life science alliance 2024 Feb;7(2)
Life science alliance 2024 Feb;7(2)
ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IĸBα ubiquitination and activating NF-ĸB signaling.
He Y, Shi Q, Ling Y, Guo H, Fei Y, Wu R, Tang C, Zhang X, Yao L
Cell death and differentiation 2024 Feb;31(2):203-216
Cell death and differentiation 2024 Feb;31(2):203-216
Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module.
Shen XJ, Wei HL, Mo XC, Mo XX, Li L, He JC, Wei XY, Qin XJ, Xing SP, Luo Z, Chen ZQ, Yang J
Acta pharmacologica Sinica 2024 Dec;45(12):2657-2671
Acta pharmacologica Sinica 2024 Dec;45(12):2657-2671
Agomelatine promotes differentiation of oligodendrocyte precursor cells and preserves white matter integrity after cerebral ischemic stroke.
Wang S, Li C, Kang X, Su X, Liu Y, Wang Y, Liu S, Deng X, Huang H, Li T, Lu D, Cai W, Lu Z, Wei L, Lu T
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2024 Dec;44(12):1487-1500
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2024 Dec;44(12):1487-1500
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes.
Xu M, Chen ZY, Li Y, Li Y, Guo G, Dai RZ, Ni N, Tao J, Wang HY, Chen QL, Wang H, Zhou H, Yang YN, Chen S, Chen L
The EMBO journal 2024 Dec;43(24):6383-6409
The EMBO journal 2024 Dec;43(24):6383-6409
Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation.
Yang C, Leifer C, Lammerding J, Hu F
The Journal of biological chemistry 2024 Dec;300(12):107999
The Journal of biological chemistry 2024 Dec;300(12):107999
Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway.
Hu R, Wu F, Zheng YQ
Redox report : communications in free radical research 2024 Dec;29(1):2332038
Redox report : communications in free radical research 2024 Dec;29(1):2332038
Siglec-5 as a novel receptor mediates endothelial cells oxLDL transcytosis to promote atherosclerosis.
Jia X, Bai X, Yin Z, Zheng Q, Zhao Y, Lu Y, Shu Y, Wang Y, Zhang Y, Jin S
Translational research : the journal of laboratory and clinical medicine 2024 Dec;274:49-66
Translational research : the journal of laboratory and clinical medicine 2024 Dec;274:49-66
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
Fang H, Xu M, Zhang J, Qin H, Tang H, He Y, Guo W
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis.
Song Z, Gao M, Li T, Zhang Y, Chen Z, Hu L, Liu J, Li Y, Wang X, Liu Y, Mo R, Xiang R, Hua D, Chen H, Zhao M, Chen X, Yao X, Yang Y
The Journal of investigative dermatology 2024 Dec;144(12):2695-2705.e8
The Journal of investigative dermatology 2024 Dec;144(12):2695-2705.e8
Effects of Antioxidant Amino Acids on Cancer Sarcopenia.
Nukaga S, Fujiwara-Tani R, Mori T, Kawahara I, Nishida R, Miyagawa Y, Goto K, Ohmori H, Fujii K, Sasaki T, Nakashima C, Luo Y, Kishi S, Ogata R, Kuniyasu H
International journal of molecular sciences 2024 Dec 31;26(1)
International journal of molecular sciences 2024 Dec 31;26(1)
Neuregulin-1 reduces Doxorubicin-induced cardiotoxicity by upregulating YAP to inhibit senescence.
Shi H, Zou Y, Li Y, Li Y, Liu B
International immunopharmacology 2024 Dec 25;143(Pt 1):113278
International immunopharmacology 2024 Dec 25;143(Pt 1):113278
Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis.
Zhang X, Ling C, Xiong Z, Gong T, Luo S, Liu X, Zhang L, Liao C, Lu Y, Huang X, Zhou W, Zhou S, Liu Y, Tang J
Cell reports 2024 Dec 24;43(12):115060
Cell reports 2024 Dec 24;43(12):115060
Role of AhR-Hsp90-MDM2-mediated VDR ubiquitination in PM2.5-induced renal toxicity.
Zhang P, Wang L, Zhang J, An Q, Wang Y, Hu N, Pu D, He L, Huang J
Environmental research 2024 Dec 15;263(Pt 2):120174
Environmental research 2024 Dec 15;263(Pt 2):120174
The essential role of TTC28 in maintaining chromosomal stability via HSPA8 chaperone-mediated autophagy.
Zhang G, Xiang M, Gu L, Zhou J, Zhang B, Tian W, Deng D
Proceedings of the National Academy of Sciences of the United States of America 2024 Dec 10;121(50):e2409447121
Proceedings of the National Academy of Sciences of the United States of America 2024 Dec 10;121(50):e2409447121
PHF2-mediated H3K9me balance orchestrates heterochromatin stability and neural progenitor proliferation.
Aguirre S, Pappa S, Serna-Pujol N, Padilla N, Iacobucci S, Nacht AS, Vicent GP, Jordan A, de la Cruz X, Martínez-Balbás MA
EMBO reports 2024 Aug;25(8):3486-3505
EMBO reports 2024 Aug;25(8):3486-3505
Tryptanthrin suppresses multiple inflammasome activation to regulate NASH progression by targeting ASC protein.
Ren L, Yang H, Wang H, Qin S, Zhan X, Li H, Wei Z, Fang Z, Li Q, Liu T, Shi W, Zhao J, Li Z, Bai Z, Xu G, Zhao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Aug;131:155758
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Aug;131:155758
Activation of nicotinic acetylcholine receptor α7 subunit limits Zika viral infection via promoting autophagy and ferroptosis.
Zhao C, Chen J, Liu Z, Liang H, Chen X, Cheng L, Xie S, Lin Z, Wu R, Zhao Q, Xue Y, Lai X, Jin X, Xu JF, Su X
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Aug 7;32(8):2641-2661
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Aug 7;32(8):2641-2661
SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis.
He X, Zhang Y, Mao Z, Liu G, Huang L, Liu X, Su Y, Xing X
Acta biochimica et biophysica Sinica 2024 Aug 6;56(11):1673-1686
Acta biochimica et biophysica Sinica 2024 Aug 6;56(11):1673-1686
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma.
Li G, Wang D, Zhai Y, Pan C, Zhang J, Wang C, Huang R, Yu M, Li Y, Liu X, Liu Y, Wu F, Zhao Z, Hu H, Shi Z, Kahlert UD, Jiang T, Zhang W
Cell metabolism 2024 Aug 6;36(8):1696-1710.e10
Cell metabolism 2024 Aug 6;36(8):1696-1710.e10
SMYD5 is a regulator of the mild hypothermia response.
Rafnsdottir S, Jang K, Halldorsdottir ST, Vinod M, Tomasdottir A, Möller K, Halldorsdottir K, Reynisdottir T, Atladottir LH, Allison KE, Ostacolo K, He J, Zhang L, Northington FJ, Magnusdottir E, Chavez-Valdez R, Anderson KJ, Bjornsson HT
Cell reports 2024 Aug 27;43(8):114554
Cell reports 2024 Aug 27;43(8):114554
PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury.
Zhao H, Liu D, Sun S, Yu J, Bian X, Cheng X, Yang Q, Yu Y, Xu Z
Free radical biology & medicine 2024 Aug 20;221:188-202
Free radical biology & medicine 2024 Aug 20;221:188-202
Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells.
Albuquerque-Souza E, Shelling B, Jiang M, Xia XJ, Rattanaprukskul K, Sahingur SE
Molecular oral microbiology 2024 Apr;39(2):29-39
Molecular oral microbiology 2024 Apr;39(2):29-39
Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action.
Yamamotoya T, Ohata Y, Akasaka Y, Hasei S, Inoue MK, Nakatsu Y, Kanna M, Yamazaki H, Kushiyama A, Fujishiro M, Ono H, Sakoda H, Yamada T, Ishihara H, Asano T
PNAS nexus 2024 Apr;3(4):pgae150
PNAS nexus 2024 Apr;3(4):pgae150
CircNOP14 increases the radiosensitivity of hepatocellular carcinoma via inhibition of Ku70-dependent DNA damage repair.
Lin L, Hu P, Luo M, Chen X, Xiao M, Zhong Z, Peng S, Chen G, Yang G, Zhang F, Zhang Y
International journal of biological macromolecules 2024 Apr;264(Pt 2):130541
International journal of biological macromolecules 2024 Apr;264(Pt 2):130541
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
Zhang R, Guan S, Meng Z, Zhang D, Lu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
Mind the Viscous Modulus: The Mechanotransductive Response to the Viscous Nature of Isoelastic Matrices Regulates Stem Cell Chondrogenesis.
Walker M, Pringle EW, Ciccone G, Oliver-Cervelló L, Tassieri M, Gourdon D, Cantini M
Advanced healthcare materials 2024 Apr;13(9):e2302571
Advanced healthcare materials 2024 Apr;13(9):e2302571
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions.
Cong J, Liu P, Han Z, Ying W, Li C, Yang Y, Wang S, Yang J, Cao F, Shen J, Zeng Y, Bai Y, Zhou C, Ye L, Zhou R, Guo C, Cang C, Kasper DL, Song X, Dai L, Sun L, Pan W, Zhu S
Immunity 2024 Apr 9;57(4):876-889.e11
Immunity 2024 Apr 9;57(4):876-889.e11
Development of a Cell Culture Model for Inducible SARS-CoV-2 Replication.
Wang X, Zhu Y, Wu Q, Jiang N, Xie Y, Deng Q
Viruses 2024 Apr 29;16(5)
Viruses 2024 Apr 29;16(5)
PICK1 inhibits the malignancy of nasopharyngeal carcinoma and serves as a novel prognostic marker.
Ou X, Zhang Y, Xu Y, Liu Y, Tu W, Hu C, Liu Y
Cell death & disease 2024 Apr 25;15(4):294
Cell death & disease 2024 Apr 25;15(4):294
TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis.
Li Y, Luan S, Ruan C, Li W, Zhang X, Ran Z, Bi W, Tong Y, Gao L, Zhao J, Li Y, He Z
Biochemical and biophysical research communications 2024 Apr 16;704:149723
Biochemical and biophysical research communications 2024 Apr 16;704:149723
Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability.
Authier F, Ondruskova N, Ferenbach AT, McNeilly AD, van Aalten DMF
Disease models & mechanisms 2024 Apr 1;17(4)
Disease models & mechanisms 2024 Apr 1;17(4)
Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6.
Yu C, Zhu Q, Ma C, Luo C, Nie L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Zhang C, Lu G, Lu Z, Zhu Y, Liu S
Frontiers in immunology 2023;14:1289795
Frontiers in immunology 2023;14:1289795
Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.
Luo W, Xu G, Song Z, Mu W, Wen J, Hui S, Zhao J, Zhan X, Bai Z, Xiao X
Frontiers in pharmacology 2023;14:1160445
Frontiers in pharmacology 2023;14:1160445
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control.
Chiu TY, Lo CH, Lin YH, Lai YD, Lin SS, Fang YT, Huang WS, Huang SY, Tsai PY, Yang FH, Chong WM, Wu YC, Tsai HC, Liu YW, Hsu CL, Liao JC, Wang WJ
Communications biology 2023 Sep 5;6(1):911
Communications biology 2023 Sep 5;6(1):911
Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns.
Pérez-Berlanga M, Wiersma VI, Zbinden A, De Vos L, Wagner U, Foglieni C, Mallona I, Betz KM, Cléry A, Weber J, Guo Z, Rigort R, de Rossi P, Manglunia R, Tantardini E, Sahadevan S, Stach O, Hruska-Plochan M, Allain FH, Paganetti P, Polymenidou M
The EMBO journal 2023 Sep 4;42(17):e111719
The EMBO journal 2023 Sep 4;42(17):e111719
Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis.
Li Z, Chen Y, Jiang X, Lu P, Wang C, Li Z, Yu X, Yang Z, Ma S, Du S, Tai Z, Li X, Zhang S, Jiang Y, Qin C
Journal of medicinal chemistry 2023 Sep 28;66(18):12966-12989
Journal of medicinal chemistry 2023 Sep 28;66(18):12966-12989
Denervation aggravates renal ischemia reperfusion injury via BMAL1-mediated Nrf2/ARE pathway.
Dong C, Li J, Tang Q, Wang Y, Zeng C, Du L, Sun Q
Archives of biochemistry and biophysics 2023 Sep 15;746:109736
Archives of biochemistry and biophysics 2023 Sep 15;746:109736
DHX9 Strengthens Atherosclerosis Progression By Promoting Inflammation in Macrophages.
Huangfu N, Ma H, Tian M, Zhang J, Wang Y, Li Z, Chen X, Cui H
Inflammation 2023 Oct;46(5):1725-1738
Inflammation 2023 Oct;46(5):1725-1738
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Yang J, Li L, Li C, Chen W, Liu Y, Luo S, Zhao C, Han Y, Yang M, Zhao H, Jiang N, Xi Y, Tang C, Cai J, Xiao L, Liu H, Sun L
Cell death & disease 2023 Oct 4;14(10):649
Cell death & disease 2023 Oct 4;14(10):649
Molecular mechanism by which RRM2-inhibitor (cholagogue osalmid) plus bafilomycin A1 cause autophagic cell death in multiple myeloma.
Guo S, Xu Z, Feng Q, Zhang H, Yu D, Li B, Hu K, Gao X, Zhang Q, Yi H, Wu X, Song D, Zhu H, Cai H, Peng Y, Zhu W, Shi J
Archives of biochemistry and biophysics 2023 Oct 1;747:109771
Archives of biochemistry and biophysics 2023 Oct 1;747:109771
Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma.
Boulos JC, Omer EA, Rigano D, Formisano C, Chatterjee M, Leich E, Klauck SM, Shan LT, Efferth T
Acta pharmacologica Sinica 2023 Nov;44(11):2265-2281
Acta pharmacologica Sinica 2023 Nov;44(11):2265-2281
Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis.
Huang X, Li X, Shen H, Zhao Y, Zhou Z, Wang Y, Yao J, Xue K, Wu D, Qiu Y
Nature communications 2023 Nov 4;14(1):7102
Nature communications 2023 Nov 4;14(1):7102
Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma.
Wang J, Zhang X, Ma X, Chen D, Cai M, Xiao L, Li J, Huang Z, Huang Y, Lian Y
Journal of experimental & clinical cancer research : CR 2023 Nov 16;42(1):303
Journal of experimental & clinical cancer research : CR 2023 Nov 16;42(1):303
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ
Nature communications 2023 Nov 1;14(1):6770
Nature communications 2023 Nov 1;14(1):6770
Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export.
Huang J, Tan X, Liu Y, Jiang K, Luo J
Molecular carcinogenesis 2023 May;62(5):700-715
Molecular carcinogenesis 2023 May;62(5):700-715
Regulatory architecture of housekeeping genes is driven by promoter assemblies.
Dejosez M, Dall'Agnese A, Ramamoorthy M, Platt J, Yin X, Hogan M, Brosh R, Weintraub AS, Hnisz D, Abraham BJ, Young RA, Zwaka TP
Cell reports 2023 May 30;42(5):112505
Cell reports 2023 May 30;42(5):112505
The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization.
Skory RM, Moverley AA, Ardestani G, Alvarez Y, Domingo-Muelas A, Pomp O, Hernandez B, Tetlak P, Bissiere S, Stern CD, Sakkas D, Plachta N
Nature communications 2023 May 29;14(1):3101
Nature communications 2023 May 29;14(1):3101
IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma.
Zhang X, Wang G, Gong Y, Zhao L, Song P, Zhang H, Zhang Y, Ju H, Wang X, Wang B, Ren H, Zhu X, Dong Y
iScience 2023 May 19;26(5):106639
iScience 2023 May 19;26(5):106639
Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation.
He X, Zhao J, Adilijiang A, Hong P, Chen P, Lin X, Xie J, Du Y, Liu Y, Lin L, Jin HY, Hong Y, Liu WH, Xiao C
Cellular & molecular immunology 2023 Mar;20(3):277-291
Cellular & molecular immunology 2023 Mar;20(3):277-291
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
Zhang Y, He B, Zhang D, Zhang Y, Chen C, Zhang W, Yang S, Yao M, Cui G, Gu J, Wang T, Lin Z, Fan Y, Xiong Z, Hao Y
Cell reports 2023 Mar 28;42(3):112188
Cell reports 2023 Mar 28;42(3):112188
DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells.
Li W, Liu S, Wang C, Cui L, Zhao X, Liu W, Zhang R, Li Z
BMC cancer 2023 Mar 18;23(1):255
BMC cancer 2023 Mar 18;23(1):255
YAP/TEAD1 and β-catenin/LEF1 synergistically induce estrogen receptor α to promote osteogenic differentiation of bone marrow stromal cells.
Wang P, Huang L, Yang F, Chen W, Bai D, Guo Y
MedComm 2023 Jun;4(3):e246
MedComm 2023 Jun;4(3):e246
Disruption of the ADAM17/NF-κB feedback loop in astrocytes ameliorates HIV-1 Tat-induced inflammatory response and neuronal death.
Qiu X, Wang J, Zhang W, Duan C, Chen T, Zhang D, Su J, Gao L
Journal of neurovirology 2023 Jun;29(3):283-296
Journal of neurovirology 2023 Jun;29(3):283-296
The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.
Niu J, Yan T, Guo W, Wang W, Ren T, Huang Y, Zhao Z, Yu Y, Chen C, Huang Q, Lou J, Guo L
Autophagy 2023 Jun;19(6):1693-1710
Autophagy 2023 Jun;19(6):1693-1710
Single cell RNA-seq resolution revealed CCR1(+)/SELL(+)/XAF(+) CD14 monocytes mediated vascular endothelial cell injuries in Kawasaki disease and COVID-19.
Liu X, Luo T, Fan Z, Li J, Zhang Y, Lu G, Lv M, Lin S, Cai Z, Zhang J, Zhou K, Guo J, Hua Y, Zhang Y, Li Y
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166707
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166707
Charged multivesicular body protein 2B ameliorates biliary injury in the liver from donation after cardiac death rats via autophagy with air-oxygenated normothermic machine perfusion.
Bai Y, Shi JH, Liu Q, Yang DJ, Yan ZP, Zhang JK, Tang HW, Guo WZ, Jin Y, Zhang SJ
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166686
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166686
Anti-oxidative-initiated cognitive impairment amelioration in Alzheimer's disease model rats through preventive transcutaneous electrical acupoint stimulation.
Weng H, Wang Q, Ye R, Bai Y, Yang H, Xu G, Wang Q
Integrative medicine research 2023 Jun;12(2):100946
Integrative medicine research 2023 Jun;12(2):100946
Role of ionizing radiation activated NRF2 in lung cancer radioresistance.
Xu Q, Zhang P, Han X, Ren H, Yu W, Hao W, Luo B, Khan MI, Chen N
International journal of biological macromolecules 2023 Jun 30;241:124476
International journal of biological macromolecules 2023 Jun 30;241:124476
SMYD3 drives the proliferation in gastric cancer cells via reducing EMP1 expression in an H4K20me3-dependent manner.
Zeng Y, Ma G, Cai F, Wang P, Liang H, Zhang R, Deng J, Liu Y
Cell death & disease 2023 Jun 29;14(6):386
Cell death & disease 2023 Jun 29;14(6):386
Ebselen alleviates white matter lesions and improves cognitive deficits by attenuating oxidative stress via Keap1/Nrf2 pathway in chronic cerebral hypoperfusion mice.
Dong F, Yan W, Meng Q, Song X, Cheng B, Liu Y, Yao R
Behavioural brain research 2023 Jun 25;448:114444
Behavioural brain research 2023 Jun 25;448:114444
SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/β-catenin signaling pathway.
Wang D, Li Y, Xu C, Wang H, Huang X, Jin X, Ren S, Gao J, Tong J, Liu J, Zhou J, Shi L
iScience 2023 Jun 16;26(6):106917
iScience 2023 Jun 16;26(6):106917
Metformin synergistically enhances the antitumour activity of Lenvatinib in hepatocellular carcinoma by altering AKT-FOXO3 signalling pathway.
Cheng Y, Zhan P, Lu J, Lu Y, Luo C, Cen X, Wang F, Xie C, Yin Z
Liver international : official journal of the International Association for the Study of the Liver 2023 Jul;43(7):1577-1592
Liver international : official journal of the International Association for the Study of the Liver 2023 Jul;43(7):1577-1592
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Hom LM, Sun S, Campbell J, Liu P, Culbert S, Murphy IM, Schafer ZT
The Journal of biological chemistry 2023 Jul;299(7):104922
The Journal of biological chemistry 2023 Jul;299(7):104922
Decreased lamin A and B1 expression results in nuclear enlargement in serous ovarian carcinoma, whereas lamin A-expressing tumor cells metastasize to lymph nodes.
Ouchi M, Kobayashi S, Nishijima Y, Inoue N, Ikota H, Iwase A, Yokoo H, Saio M
Pathology, research and practice 2023 Jul;247:154560
Pathology, research and practice 2023 Jul;247:154560
Alpinia oxyphylla Miq. volatile oil ameliorates depressive behaviors and inhibits neuroinflammation in CUMS-exposed mice by inhibiting the TLR4-medicated MyD88/NF-κB signaling pathway.
Wu B, Gan A, Wang R, Lin F, Yan T, Jia Y
Journal of chemical neuroanatomy 2023 Jul;130:102270
Journal of chemical neuroanatomy 2023 Jul;130:102270
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D, Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE, Upton JW, Li P, West AP
Cell 2023 Jul 6;186(14):3013-3032.e22
Cell 2023 Jul 6;186(14):3013-3032.e22
circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells.
Bai Y, Zhang L, Zheng B, Zhang X, Zhang H, Zhao A, Yu J, Yang Z, Wen J
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
Cellular and molecular life sciences : CMLS 2023 Jul 27;80(8):229
JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis.
Jia Q, Tan Y, Li Y, Wu Y, Wang J, Tang F
Cell death & disease 2023 Jul 21;14(7):459
Cell death & disease 2023 Jul 21;14(7):459
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W
Cancer letters 2023 Jul 10;566:216244
Cancer letters 2023 Jul 10;566:216244
NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury.
Liu J, Liu J, Meng C, Gu Q, Huang C, Liu F, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154529
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154529
CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
Yu X, Tong H, Chen J, Tang C, Wang S, Si Y, Wang S, Tang Z
Cell death & disease 2023 Jan 12;14(1):20
Cell death & disease 2023 Jan 12;14(1):20
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Xu M, Zhou Y, Fan S, Zhang M, Gao X
Amino acids 2023 Feb;55(2):243-252
Amino acids 2023 Feb;55(2):243-252
Absence of indoleamine 2,3‑dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice.
Ando T, Hoshi M, Tezuka H, Ito H, Nakamoto K, Yamamoto Y, Saito K
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage.
Wang Z, Li T, Du M, Zhang L, Xu L, Song H, Zhang J
Brain research bulletin 2023 Feb;193:117-130
Brain research bulletin 2023 Feb;193:117-130
Influence of RRM, RGG and Potential Phosphorylated Sites in Cold-Inducible Protein RBM3 on its Subcellular Localization and Neuroprotective Effects.
Wang L, Shao TC, Wang CY, Li JJ, Jian SQ, Wang D, Cheng BF
Frontiers in bioscience (Landmark edition) 2023 Feb 8;28(2):24
Frontiers in bioscience (Landmark edition) 2023 Feb 8;28(2):24
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Hom LM, Sun S, Campbell J, Liu P, Culbert S, Murphy IM, Schafer ZT
bioRxiv : the preprint server for biology 2023 Feb 22;
bioRxiv : the preprint server for biology 2023 Feb 22;
The Integrator complex regulates microRNA abundance through RISC loading.
Kirstein N, Dokaneheifard S, Cingaram PR, Valencia MG, Beckedorff F, Gomes Dos Santos H, Blumenthal E, Tayari MM, Gaidosh GS, Shiekhattar R
Science advances 2023 Feb 10;9(6):eadf0597
Science advances 2023 Feb 10;9(6):eadf0597
UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer.
Hong X, Ma N, Li D, Zhang M, Dong W, Huang J, Ci X, Zhang S
Cell death & disease 2023 Feb 10;14(2):100
Cell death & disease 2023 Feb 10;14(2):100
FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway.
Zhou Y, Chen Y, Shi Y, Wu L, Tan Y, Li T, Chen Y, Xia J, Hu R
The Journal of clinical investigation 2023 Feb 1;133(3)
The Journal of clinical investigation 2023 Feb 1;133(3)
The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells.
Zhou M, Boulos JC, Klauck SM, Efferth T
Cell biology and toxicology 2023 Dec;39(6):2971-2997
Cell biology and toxicology 2023 Dec;39(6):2971-2997
Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells.
Qi H, Lin G, Guo S, Guo X, Yu C, Zhang M, Gao X
Animal biotechnology 2023 Dec;34(8):4094-4104
Animal biotechnology 2023 Dec;34(8):4094-4104
Conessine inhibits enveloped viruses replication through up-regulating cholesterol level.
Zhou S, Li J, Ling X, Dong S, Zhang Z, Li M
Virus research 2023 Dec;338:199234
Virus research 2023 Dec;338:199234
Function of m(5)C RNA methyltransferase NOP2 in high-grade serous ovarian cancer.
Yang S, Zhou D, Zhang C, Xiang J, Xi X
Cancer biology & therapy 2023 Dec 31;24(1):2263921
Cancer biology & therapy 2023 Dec 31;24(1):2263921
A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.
Kuang H, Li Y, Wang Y, Shi M, Duan R, Xiao Q, She H, Liu Y, Liang Q, Teng Y, Zhou M, Liang D, Li Z, Wu L
Cell reports 2023 Dec 26;42(12):113445
Cell reports 2023 Dec 26;42(12):113445
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
Xu S, Wang N, Zuccaro MV, Gerhardt J, Baslan T, Koren A, Egli D
bioRxiv : the preprint server for biology 2023 Dec 26;
bioRxiv : the preprint server for biology 2023 Dec 26;
Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity.
Zhang X, Wu N, Huang H, Li S, Liu S, Zhang R, Huang Y, Lyu H, Xiao S, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J
Oncogene 2023 Aug;42(32):2439-2455
Oncogene 2023 Aug;42(32):2439-2455
HIV-1 subtype B Tat enhances NOTCH3 signaling in astrocytes to mediate oxidative stress, inflammatory response, and neuronal apoptosis.
Gao L, Sun W, Zhang D, Shang Y, Li L, Tao W, Zhang L, Liu H
Journal of neurovirology 2023 Aug;29(4):479-491
Journal of neurovirology 2023 Aug;29(4):479-491
Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin.
Deng DX, Li CY, Zheng ZY, Wen B, Liao LD, Zhang XJ, Li EM, Xu LY
Molecular & cellular proteomics : MCP 2023 Aug;22(8):100593
Molecular & cellular proteomics : MCP 2023 Aug;22(8):100593
Characterizing microglial senescence: Tau as a key player.
Karabag D, Scheiblich H, Griep A, Santarelli F, Schwartz S, Heneka MT, Ising C
Journal of neurochemistry 2023 Aug;166(3):517-533
Journal of neurochemistry 2023 Aug;166(3):517-533
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Wang H, Qiu Y, Zhang H, Chang N, Hu Y, Chen J, Hu R, Liao P, Li Z, Yang Y, Cen Q, Ding X, Li M, Xie X, Li Y
Cell death & disease 2023 Aug 4;14(8):498
Cell death & disease 2023 Aug 4;14(8):498
The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation.
Xie J, Du Y, Liu D, Wu J, Yang K, He X, Zhao J, Hong P, Liao K, Zhang H, Hong Y, Teijaro JR, Kang SG, Xiao C, Liu WH
Cell reports 2023 Aug 29;42(8):112968
Cell reports 2023 Aug 29;42(8):112968
HHEX suppresses advanced thyroid cancer by interacting with TLE3.
Xu Z, Feng Y, Yan Y, Jin H, Chen Y, Han Y, Huang S, Feng F, Fu H, Yin Y, Huang Y, Wang H, Cheng W
Molecular and cellular endocrinology 2023 Aug 20;574:111988
Molecular and cellular endocrinology 2023 Aug 20;574:111988
Carteolol triggers senescence via activation of β-arrestin-ERK-NOX4-ROS pathway in human corneal endothelial cells in vitro.
Jiang GJ, You XG, Fan TJ
Chemico-biological interactions 2023 Aug 1;380:110511
Chemico-biological interactions 2023 Aug 1;380:110511
Co-Expression of Chromatin Assembly Factor 1 Subunit A and Proliferating Cell Nuclear Antigen Is a Prognostic Biomarker of Esophageal Cancer.
Wen B, Deng DX, Liao LD, Zhang ZD, Zheng YQ, Dong K, Xu LY, Li EM
Biomedicines 2023 Apr 16;11(4)
Biomedicines 2023 Apr 16;11(4)
Edaravone Ameliorates Cerebral Ischemia-Reperfusion Injury by Downregulating Ferroptosis via the Nrf2/FPN Pathway in Rats.
Liu W, Wang L, Liu C, Dai Z, Li T, Tang B
Biological & pharmaceutical bulletin 2022;45(9):1269-1275
Biological & pharmaceutical bulletin 2022;45(9):1269-1275
LPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis.
Li MZ, Wen XY, Liu XQ, Wang YQ, Yan L
Journal of inflammation research 2022;15:5707-5720
Journal of inflammation research 2022;15:5707-5720
Bergenin ameliorates airway inflammation and remodeling in asthma by activating SIRT1 in macrophages to regulate the NF-κB pathway.
Huang D, Sun C, Chen M, Bai S, Zhao X, Wang W, Geng K, Huang W, Zhao T, Wu B, Zhang G, Wu D, Xu Y
Frontiers in pharmacology 2022;13:994878
Frontiers in pharmacology 2022;13:994878
Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice.
Ye Z, Ma J, Liu Y, Xu B, Dai X, Fu M, Tian T, Sui X, Mo F, Gao S, Zhao D, Zhang D
Frontiers in pharmacology 2022;13:950535
Frontiers in pharmacology 2022;13:950535
Allyl methyl trisulfide protected against LPS-induced acute lung injury in mice via inhibition of the NF-κB and MAPK pathways.
Wang S, Liu J, Dong J, Fan Z, Wang F, Wu P, Li X, Kou R, Chen F
Frontiers in pharmacology 2022;13:919898
Frontiers in pharmacology 2022;13:919898
Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B-Lamin B1 Interaction in Alcoholic Fatty Liver Disease.
Qi X, Zheng S, Ma M, Lian N, Wang H, Chen L, Song A, Lu C, Zheng S, Jin H
Frontiers in pharmacology 2022;13:912825
Frontiers in pharmacology 2022;13:912825
Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway.
Qu XQ, Chen QF, Shi QQ, Luo QQ, Zheng SY, Li YH, Bai LY, Gan S, Zhou XY
Frontiers in immunology 2022;13:901566
Frontiers in immunology 2022;13:901566
The Protective Effect of Evodiamine in Osteoarthritis: An In Vitro and In Vivo Study in Mice Model.
Xian S, Lin Z, Zhou C, Wu X
Frontiers in pharmacology 2022;13:899108
Frontiers in pharmacology 2022;13:899108
Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.
Wu X, Zhao K, Fang X, Lu F, Cheng P, Song X, Zhang W, Yao C, Zhu J, Chen H
Frontiers in pharmacology 2022;13:845959
Frontiers in pharmacology 2022;13:845959
Hypoxic Cell-Derived Extracellular Vesicles Aggravate Rectal Injury Following Radiotherapy via MiR-122-5p.
Xu Y, Ge Y, Chen X, Zhang Y, Chen H, Liu D, Lu Y, Liu Y, Tu W
Frontiers in cell and developmental biology 2022;10:892575
Frontiers in cell and developmental biology 2022;10:892575
Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1.
Tian W, Yuan H, Qin S, Liu W, Zhang B, Gu L, Zhou J, Deng D
Molecular oncology 2022 Sep;16(17):3192-3209
Molecular oncology 2022 Sep;16(17):3192-3209
RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ.
Tang H, Li X, Jiang L, Liu Z, Chen L, Chen J, Deng M, Zhou F, Zheng X, Liu Z
Cancer science 2022 Sep;113(9):3071-3084
Cancer science 2022 Sep;113(9):3071-3084
Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe.
Luo S, He J, Huang S, Wang X, Su Y, Li Y, Chen Y, Yang G, Huang B, Guo S, Zhou L, Luo X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154106
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154106
Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte.
Wang SH, Chen YS, Lai KH, Lu CK, Chang HS, Wu HC, Yen FL, Chen LY, Lee JC, Yen CH
Antioxidants (Basel, Switzerland) 2022 Sep 5;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 5;11(9)
A Novel, Fully Spliced, Accessory Gene in Equine Lentivirus with Distinct Rev-Responsive Element.
Zhang X, Li J, Zhang M, Bai B, Ma W, Lin Y, Guo X, Wang XF, Wang X
Journal of virology 2022 Sep 28;96(18):e0098622
Journal of virology 2022 Sep 28;96(18):e0098622
Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.
Ye C, Li H, Li Y, Zhang Y, Liu G, Mi H, Li H, Xiao Q, Niu L, Yu X
iScience 2022 Sep 16;25(9):104872
iScience 2022 Sep 16;25(9):104872
TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation.
Wang L, Li J, Wang Q, Ge MX, Ji J, Liu D, Wang Z, Cao Y, Zhang Y, Zhang ZR
Molecular cell 2022 Sep 15;82(18):3453-3467.e14
Molecular cell 2022 Sep 15;82(18):3453-3467.e14
GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis.
Wang M, Han X, Zha W, Wang X, Liu L, Li Z, Shi Y, Kan X, Wang G, Gao D, Zhang B
Molecular neurobiology 2022 Oct;59(10):6321-6340
Molecular neurobiology 2022 Oct;59(10):6321-6340
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression.
Guo Y, He J, Zhang H, Chen R, Li L, Liu X, Huang C, Qiang Z, Zhou Z, Wang Y, Huang J, Zhao X, Zheng J, Chen GQ, Yu J
Oncogene 2022 Oct;41(44):4877-4892
Oncogene 2022 Oct;41(44):4877-4892
Ultraviolet B irradiation induces senescence of human corneal endothelial cells in vitro by DNA damage response and oxidative stress.
Jiang GJ, You XG, Fan TJ
Journal of photochemistry and photobiology. B, Biology 2022 Oct;235:112568
Journal of photochemistry and photobiology. B, Biology 2022 Oct;235:112568
Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells.
Lyu R, Zhu X, Shen Y, Xiong L, Liu L, Liu H, Wu F, Argueta C, Tan L
Epigenetics 2022 Oct;17(10):1180-1194
Epigenetics 2022 Oct;17(10):1180-1194
Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage.
Arakawa N, Ushiki A, Abe M, Matsuyama S, Saito Y, Kashiwada T, Horimasu Y, Gemma A, Tatsumi K, Hattori N, Tsushima K, Miyashita K, Saito K, Nakamura R, Toyoda T, Ogawa K, Sato M, Takamatsu K, Mori K, Nishiya T, Izumi T, Ohno Y, Saito Y, Hanaoka M
Nature communications 2022 Oct 4;13(1):5854
Nature communications 2022 Oct 4;13(1):5854
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
Wu B, Feng J, Guo J, Wang J, Xiu G, Xu J, Ning K, Ling B, Fu Q, Xu J
Stem cell research & therapy 2022 Oct 4;13(1):494
Stem cell research & therapy 2022 Oct 4;13(1):494
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350
Nature communications 2022 Oct 26;13(1):6350
Free and Bound Phenolics of Laird Lentil (Lens culinaris) Hulls and the Anti-inflammatory Activity of their Digestive Products via Crosstalk between NF-κB and Keap1-Nrf2 Signaling Pathways in HT-29 Cells.
Guo F, Peng L, Xiong H, Wang J, Tsao R, Peng X, Jiang L, Sun Y
Journal of agricultural and food chemistry 2022 Oct 19;70(41):13251-13263
Journal of agricultural and food chemistry 2022 Oct 19;70(41):13251-13263
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.
Shen H, Huang X, Zhao Y, Wu D, Xue K, Yao J, Wang Y, Tang N, Qiu Y
Nature communications 2022 Oct 13;13(1):6030
Nature communications 2022 Oct 13;13(1):6030
Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation.
Liu H, Liu Y, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(32):e2203995
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(32):e2203995
Exposure to Multiwall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis.
Tsunematsu T, Arakaki R, Sato M, Saito M, Otsuka K, Furukawa Y, Taquahashi Y, Kanno J, Ishimaru N
The American journal of pathology 2022 Nov;192(11):1559-1572
The American journal of pathology 2022 Nov;192(11):1559-1572
BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells.
Liu C, Yu J, Liu B, Liu M, Song G, Zhu L, Peng B
BMC oral health 2022 Nov 24;22(1):536
BMC oral health 2022 Nov 24;22(1):536
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis.
Paul S, Kaplan MH, Khanna D, McCourt PM, Saha AK, Tsou PS, Anand M, Radecki A, Mourad M, Sawalha AH, Markovitz DM, Contreras-Galindo R
Nature communications 2022 Nov 18;13(1):7074
Nature communications 2022 Nov 18;13(1):7074
Major Vault Protein Prevents Atherosclerotic Plaque Destabilization by Suppressing Macrophage ASK1-JNK Signaling.
Liu Q, Pan J, Bao L, Xu C, Qi Y, Jiang B, Wang D, Zhu X, Li X, Zhang H, Bai H, Yang Q, Ma J, Wiemer EAC, Ben J, Chen Q
Arteriosclerosis, thrombosis, and vascular biology 2022 May;42(5):580-596
Arteriosclerosis, thrombosis, and vascular biology 2022 May;42(5):580-596
Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment.
Mei Z, Yang T, Liu Y, Gao Y, Hou Z, Zhuang Q, He D, Zhang X, Tan Q, Zhu X, Qin Y, Chen X, Xu C, Bian C, Wang X, Wang C, Wu D, Huang S, Li Z
Cell reports. Medicine 2022 May 17;3(5):100608
Cell reports. Medicine 2022 May 17;3(5):100608
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Deacetylation of ZKSCAN3 by SIRT1 induces autophagy and protects SN4741 cells against MPP(+)-induced oxidative stress.
Wu X, Ren Y, Wen Y, Lu S, Li H, Yu H, Li W, Zou F
Free radical biology & medicine 2022 Mar;181:82-97
Free radical biology & medicine 2022 Mar;181:82-97
Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner.
Zheng C, Yu X, Liang Y, Zhu Y, He Y, Liao L, Wang D, Yang Y, Yin X, Li A, He Q, Li B
Acta pharmaceutica Sinica. B 2022 Mar;12(3):1271-1287
Acta pharmaceutica Sinica. B 2022 Mar;12(3):1271-1287
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit.
Gao X, You J, Gong Y, Yuan M, Zhu H, Fang L, Zhu H, Ying M, He Q, Yang B, Cao J
Acta pharmaceutica Sinica. B 2022 Mar;12(3):1225-1239
Acta pharmaceutica Sinica. B 2022 Mar;12(3):1225-1239
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Qi H, Wang L, Zhang M, Wang Z, Gao X, Li M
The Journal of nutritional biochemistry 2022 Mar;101:108924
The Journal of nutritional biochemistry 2022 Mar;101:108924
Dynamic control of chromatin-associated m(6)A methylation regulates nascent RNA synthesis.
Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H
Molecular cell 2022 Mar 17;82(6):1156-1168.e7
Molecular cell 2022 Mar 17;82(6):1156-1168.e7
Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition.
Wang F, Li S, Houerbi N, Chou TF
Cell chemical biology 2022 Mar 17;29(3):517-529.e5
Cell chemical biology 2022 Mar 17;29(3):517-529.e5
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
Yu X, Jiang N, Li J, Li X, He S
Tissue & cell 2022 Jun;76:101813
Tissue & cell 2022 Jun;76:101813
Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway.
Han X, Zhang J, Zhou L, Wei J, Tu Y, Shi Q, Zhang Y, Ren J, Wang Y, Ying H, Liang G
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
Phytotherapy research : PTR 2022 Jun;36(6):2511-2523
SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs.
Cao L, Luo Y, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y, You F
PLoS pathogens 2022 Jun;18(6):e1010599
PLoS pathogens 2022 Jun;18(6):e1010599
NPM1 promotes cell proliferation by targeting PRDX6 in colorectal cancer.
Wang D, Li Y, Liu Y, Cheng S, Liu F, Zuo R, Ding C, Shi S, Liu G
The international journal of biochemistry & cell biology 2022 Jun;147:106233
The international journal of biochemistry & cell biology 2022 Jun;147:106233
Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription.
Wen J, Zhao C, Chen J, Song S, Lin Z, Xie S, Qi H, Wang J, Su X
Cell insight 2022 Jun;1(3):100028
Cell insight 2022 Jun;1(3):100028
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
Zhao L, Zhao Y, Liu Q, Huang J, Lu Y, Ping J
Microbiology spectrum 2022 Jun 29;10(3):e0109822
Microbiology spectrum 2022 Jun 29;10(3):e0109822
TRIM62 silencing represses the proliferation and invasion and increases the chemosensitivity of hepatocellular carcinoma cells by affecting the NF-κB pathway.
Fan W, Liu X, Ren D
Toxicology and applied pharmacology 2022 Jun 15;445:116035
Toxicology and applied pharmacology 2022 Jun 15;445:116035
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation.
Arya SB, Chen S, Jordan-Javed F, Parent CA
Nature cell biology 2022 Jul;24(7):1019-1028
Nature cell biology 2022 Jul;24(7):1019-1028
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
Huo K, Ma KG, Guo QY, Duan P, Xu J
International immunopharmacology 2022 Jul;108:108718
International immunopharmacology 2022 Jul;108:108718
DNA Repair Factor Poly(ADP-Ribose) Polymerase 1 Is a Proviral Factor in Hepatitis B Virus Covalently Closed Circular DNA Formation.
Chen Y, Yao Y, Zhao K, Liu C, Yuan Y, Sun H, Huang D, Zheng Y, Zhou Y, Chen J, Wang Y, Wu C, Zhang B, Guan Y, Li F, Pei R, Chen X
Journal of virology 2022 Jul 13;96(13):e0058522
Journal of virology 2022 Jul 13;96(13):e0058522
TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1.
Yi L, Hu Y, Wu Z, Li Y, Kong M, Kang Z, Zuoyuan B, Yang Z
Cell death & disease 2022 Jul 11;13(7):592
Cell death & disease 2022 Jul 11;13(7):592
METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice.
Barajas JM, Lin CH, Sun HL, Alencastro F, Zhu AC, Aljuhani M, Navari L, Yilmaz SA, Yu L, Corps K, He C, Duncan AW, Ghoshal K
The American journal of pathology 2022 Jan;192(1):56-71
The American journal of pathology 2022 Jan;192(1):56-71
3-(3-Hydroxyphenyl)propionic acid, a microbial metabolite of quercetin, inhibits monocyte binding to endothelial cells via modulating E-selectin expression.
Feng J, Ge C, Li W, Li R
Fitoterapia 2022 Jan;156:105071
Fitoterapia 2022 Jan;156:105071
Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection.
Xu B, Yang R, Yang B, Li L, Chen J, Fu J, Qu X, Huo D, Tan C, Chen H, Peng Z, Wang X
Molecular brain 2022 Jan 3;15(1):4
Molecular brain 2022 Jan 3;15(1):4
Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes.
Chen H, Ma J, Liu J, Dou L, Shen T, Zuo H, Xu F, Zhao L, Tang W, Man Y, Ma Y, Li J, Huang X
FEBS letters 2022 Feb;596(4):510-525
FEBS letters 2022 Feb;596(4):510-525
The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.
Li M, Rao X, Cui Y, Zhang L, Li X, Wang B, Zheng Y, Teng L, Zhou T, Zhuo W
Oncogene 2022 Feb;41(6):770-781
Oncogene 2022 Feb;41(6):770-781
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
Bryant JD, Lei Y, VanPortfliet JJ, Winters AD, West AP
Current protocols 2022 Feb;2(2):e372
Current protocols 2022 Feb;2(2):e372
RETRACTED: TRIM21 deficiency confers protection from OGD/R-induced oxidative and inflammatory damage in cultured hippocampal neurons through regulation of the Keap1/Nrf2 pathway.
Fu Y, Gao J, Li Y, Yang X, Zhang Y
International immunopharmacology 2022 Feb;103:108414
International immunopharmacology 2022 Feb;103:108414
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction.
Li Q, Feng H, Wang H, Wang Y, Mou W, Xu G, Zhang P, Li R, Shi W, Wang Z, Fang Z, Ren L, Wang Y, Lin L, Hou X, Dai W, Li Z, Wei Z, Liu T, Wang J, Guo Y, Li P, Zhao X, Zhan X, Xiao X, Bai Z
EMBO reports 2022 Feb 3;23(2):e53499
EMBO reports 2022 Feb 3;23(2):e53499
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Ni L, Xiao J, Zhang D, Shao Z, Huang C, Wang S, Wu Y, Tian N, Sun L, Wu A, Zhou Y, Wang X, Zhang X
Cell death & disease 2022 Feb 10;13(2):140
Cell death & disease 2022 Feb 10;13(2):140
HIV-1 Tat drives the Fabp4/NF-κB feedback loop in microglia to mediate inflammatory response and neuronal apoptosis.
Zhou X, Zhou S, Tao J, Gao Y, Meng G, Cao D, Gao L
Journal of neurovirology 2022 Dec;28(4-6):483-496
Journal of neurovirology 2022 Dec;28(4-6):483-496
Blockade of CBX4-mediated β-catenin SUMOylation attenuates airway epithelial barrier dysfunction in asthma.
Liang S, Zhou Z, Zhou Z, Liang J, Lin W, Zhang C, Zhou C, Zhao H, Meng X, Zou F, Yu C, Cai S
International immunopharmacology 2022 Dec;113(Pt A):109333
International immunopharmacology 2022 Dec;113(Pt A):109333
Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3.
Bai Y, Liu J, Jiang X, Li X, Zhang B, Luo X
Cells 2022 Dec 3;11(23)
Cells 2022 Dec 3;11(23)
Onset of p53/NF-κB signaling crosstalk in human melanoma cells in response to anti-cancer theabrownin.
Li T, Yan B, Xiao X, Zhou L, Zhang J, Yuan Q, Shan L, Wu H, Efferth T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Aug;36(8):e22426
METTL3 preferentially enhances non-m(6)A translation of epigenetic factors and promotes tumourigenesis.
Wei X, Huo Y, Pi J, Gao Y, Rao S, He M, Wei Q, Song P, Chen Y, Lu D, Song W, Liang J, Xu L, Wang H, Hong G, Guo Y, Si Y, Xu J, Wang X, Ma Y, Yu S, Zou D, Jin J, Wang F, Yu J
Nature cell biology 2022 Aug;24(8):1278-1290
Nature cell biology 2022 Aug;24(8):1278-1290
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export.
Hall R, Guedán A, Yap MW, Young GR, Harvey R, Stoye JP, Bishop KN
PLoS pathogens 2022 Aug;18(8):e1010349
PLoS pathogens 2022 Aug;18(8):e1010349
Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism.
Li T, Zhou L, Fan M, Chen Z, Yan L, Lu H, Jia M, Wu H, Shan L
Stem cell reviews and reports 2022 Aug;18(6):2088-2103
Stem cell reviews and reports 2022 Aug;18(6):2088-2103
Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway.
Jiang Y, Li JJ, Mu YW, Jiang HY, Wei ZX, Xiao ZY, Zhao JJ, Chen XH
Neurotoxicity research 2022 Apr;40(2):365-372
Neurotoxicity research 2022 Apr;40(2):365-372
YB-1 Recruits Drosha to Promote Splicing of pri-miR-192 to Mediate the Proangiogenic Effects of H(2)S.
Zhou Y, Li XH, Xue WL, Jin S, Li MY, Zhang CC, Yu B, Zhu L, Liang K, Chen Y, Tao BB, Zhu YZ, Wang MJ, Zhu YC
Antioxidants & redox signaling 2022 Apr;36(10-12):760-783
Antioxidants & redox signaling 2022 Apr;36(10-12):760-783
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Antioxidant Activity of Acanthopanax senticosus Flavonoids in H(2)O(2)-Induced RAW 264.7 Cells and DSS-Induced Colitis in Mice.
Su J, Zhang X, Kan Q, Chu X
Molecules (Basel, Switzerland) 2022 Apr 30;27(9)
Molecules (Basel, Switzerland) 2022 Apr 30;27(9)
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
Yang Y, Liu S, He C, Lv T, Zeng L, Zhang F, Chen H, Zhao RC
Cell & bioscience 2022 Apr 21;12(1):45
Cell & bioscience 2022 Apr 21;12(1):45
Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.
Zhou Z, Li H, Bai S, Xu Z, Jiao Y
Biochemical and biophysical research communications 2022 Apr 16;600:87-93
Biochemical and biophysical research communications 2022 Apr 16;600:87-93
PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway.
Li H, Wang C, Lan L, Wu W, Evans I, Ruiz EJ, Yan L, Zhou Z, Oliveira JM, Reis RL, Hu Z, Chen W, Behrens A, He Y, Zhang C
Frontiers in cell and developmental biology 2021;9:719192
Frontiers in cell and developmental biology 2021;9:719192
Arid4b alters cell cycle and cell death dynamics during mouse embryonic stem cell differentiation.
GÜven G, Terzİ ÇİzmecİoĞlu N
Turkish journal of biology = Turk biyoloji dergisi 2021;45(1):56-64
Turkish journal of biology = Turk biyoloji dergisi 2021;45(1):56-64
Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1.
Hu X, Li M, Zhang C, Pang S
International journal of endocrinology 2021;2021:8867218
International journal of endocrinology 2021;2021:8867218
Protective Effect of Jiang Tang Xiao Ke Granules against Skeletal Muscle IR via Activation of the AMPK/SIRT1/PGC-1α Signaling Pathway.
Bai Y, Zuo J, Fang X, Ma R, Tian T, Mo F, Mu Q, Zhang Y, Yu N, Bao X, Zhang D, Gao S, Zhao D
Oxidative medicine and cellular longevity 2021;2021:5566053
Oxidative medicine and cellular longevity 2021;2021:5566053
GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy.
Guo W, Li W, Su Y, Liu S, Kan X, Ran X, Cao Y, Fu S, Liu J
International journal of biological sciences 2021;17(15):4271-4284
International journal of biological sciences 2021;17(15):4271-4284
Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.
Wang CM, Li HF, Wang XK, Li WG, Su Q, Xiao X, Hao TF, Chen W, Zhang YW, Zhang HY, Wu W, Hu ZR, Zhao GY, Huo MY, He YL, Zhang CH
International journal of biological sciences 2021;17(11):2811-2825
International journal of biological sciences 2021;17(11):2811-2825
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Pang Z, Jiang Z, Zhu R, Song C, Tang H, Cao L, Guo C
Drug design, development and therapy 2021;15:3735-3747
Drug design, development and therapy 2021;15:3735-3747
Transcription Coactivator BCL3 Acts as a Potential Regulator of Lipid Metabolism Through the Effects on Inflammation.
Zhang S, Gao J, Liu S, Yu L, Zhang W, Liang Y, Wang H
Journal of inflammation research 2021;14:4915-4926
Journal of inflammation research 2021;14:4915-4926
Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.
Jia Y, Li J, Liu P, Si M, Jin Y, Wang H, Ma D, Chu L
Frontiers in pharmacology 2021;12:758670
Frontiers in pharmacology 2021;12:758670
PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress.
Yin L, Li H, Liu Z, Wu W, Cai J, Tang C, Dong Z
Frontiers in immunology 2021;12:690697
Frontiers in immunology 2021;12:690697
Angelica Polysaccharide Antagonizes 5-FU-Induced Oxidative Stress Injury to Reduce Apoptosis in the Liver Through Nrf2 Pathway.
Zeng D, Wang Y, Chen Y, Li D, Li G, Xiao H, Hou J, Wang Z, Hu L, Wang L, Li J
Frontiers in oncology 2021;11:720620
Frontiers in oncology 2021;11:720620
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration.
Guedán A, Donaldson CD, Caroe ER, Cosnefroy O, Taylor IA, Bishop KN
PLoS pathogens 2021 Sep;17(9):e1009484
PLoS pathogens 2021 Sep;17(9):e1009484
MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-κB signaling.
Wang Y, Zhang J, Li YJ, Yu NN, Liu WT, Liang JZ, Xu WW, Sun ZH, Li B, He QY
Journal of experimental & clinical cancer research : CR 2021 Sep 24;40(1):301
Journal of experimental & clinical cancer research : CR 2021 Sep 24;40(1):301
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing.
Zhang Q, Zhang J, Ye J, Li X, Liu H, Ma X, Wang C, He K, Zhang W, Yuan J, Zhao Y, Xu H, Liu Q
Molecular neurodegeneration 2021 Sep 22;16(1):66
Molecular neurodegeneration 2021 Sep 22;16(1):66
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt.
Liu C, Ma L, Wang Y, Zhao J, Chen P, Chen X, Wang Y, Hu Y, Liu Y, Jia X, Yang Z, Yin X, Wu J, Wu S, Zheng H, Ma X, Sun X, He Y, Lin L, Fu Y, Liao K, Zhou X, Jiang S, Fu G, Tang J, Han W, Chen XL, Fan W, Hong Y, Han J, Huang X, Li BA, Xiao N, Xiao C, Fu G, Liu WH
Science advances 2021 Oct 8;7(41):eabg6262
Science advances 2021 Oct 8;7(41):eabg6262
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Han Y, Xiong S, Zhao H, Yang S, Yang M, Zhu X, Jiang N, Xiong X, Gao P, Wei L, Xiao Y, Sun L
Cell death & disease 2021 Oct 30;12(11):1031
Cell death & disease 2021 Oct 30;12(11):1031
The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation.
Li Y, Zhang N, Ma C, Xu W, Jin G, Zheng Y, Zhang L, Liu B, Gao C, Liu S
Cell death & disease 2021 Oct 26;12(11):1001
Cell death & disease 2021 Oct 26;12(11):1001
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
Wang F, Zhang Y, Yu X, Teng XL, Ding R, Hu Z, Wang A, Wang Z, Ye Y, Zou Q
The Journal of clinical investigation 2021 Oct 1;131(19)
The Journal of clinical investigation 2021 Oct 1;131(19)
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation.
Lu ZN, Niu WX, Zhang N, Ge MX, Bao YY, Ren Y, Guo XL, He HW
Acta pharmacologica Sinica 2021 Nov;42(11):1808-1820
Acta pharmacologica Sinica 2021 Nov;42(11):1808-1820
Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization.
Jin J, Tong X, Zhang YL, Yang W, Ma Y, Ren P, Zhou F, Zhang S
Journal of assisted reproduction and genetics 2021 Nov;38(11):2861-2869
Journal of assisted reproduction and genetics 2021 Nov;38(11):2861-2869
ATRX proximal protein associations boast roles beyond histone deposition.
Scott WA, Dhanji EZ, Dyakov BJA, Dreseris ES, Asa JS, Grange LJ, Mirceta M, Pearson CE, Stewart GS, Gingras AC, Campos EI
PLoS genetics 2021 Nov;17(11):e1009909
PLoS genetics 2021 Nov;17(11):e1009909
DNMT1-induced miR-378a-3p silencing promotes angiogenesis via the NF-κB signaling pathway by targeting TRAF1 in hepatocellular carcinoma.
Zhu B, Chen JJ, Feng Y, Yang JL, Huang H, Chung WY, Hu YL, Xue WJ
Journal of experimental & clinical cancer research : CR 2021 Nov 8;40(1):352
Journal of experimental & clinical cancer research : CR 2021 Nov 8;40(1):352
KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.
Pang L, Tian H, Gao X, Wang W, Wang X, Zhang Z
Bioscience reports 2021 Nov 26;41(11)
Bioscience reports 2021 Nov 26;41(11)
Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation.
Wei M, Huang J, Li GW, Jiang B, Cheng H, Liu X, Jiang X, Zhang X, Yang L, Bao L, Wang B
Cell reports 2021 May 4;35(5):109053
Cell reports 2021 May 4;35(5):109053
TET2 Inhibits PD-L1 Gene Expression in Breast Cancer Cells through Histone Deacetylation.
Shen Y, Liu L, Wang M, Xu B, Lyu R, Shi YG, Tan L
Cancers 2021 May 4;13(9)
Cancers 2021 May 4;13(9)
The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Chen Y, Wang Y, Chen J, Zuo W, Fan Y, Huang S, Liu Y, Chen G, Li Q, Li J, Wu J, Bian Q, Huang C, Lei M
Nature communications 2021 May 26;12(1):3176
Nature communications 2021 May 26;12(1):3176
Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury.
Wang Y, Xu G, Wang Z, Li R, Zhan X, Liu H, Qin Q, Li W, Wang X, Zhang M, Tang J, Bai Z, Xiao X
International immunopharmacology 2021 Mar;92:107352
International immunopharmacology 2021 Mar;92:107352
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
Luo X, Bai Y, He S, Sun S, Jiang X, Yang Z, Lu D, Wei P, Liang Y, Peng C, Wang Y, Sheng R, Han S, Li X, Zhang B
Cell proliferation 2021 Mar;54(3):e12991
Cell proliferation 2021 Mar;54(3):e12991
miR-142-3p reduces the viability of human cervical cancer cells by negatively regulating the cytoplasmic localization of HMGB1.
Dong H, Song J
Experimental and therapeutic medicine 2021 Mar;21(3):212
Experimental and therapeutic medicine 2021 Mar;21(3):212
Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway.
Yang S, Jiang W, Yang W, Yang C, Yang X, Chen K, Hu Y, Shen G, Lu L, Cheng F, Zhang F, Rao J, Wang X
Molecular therapy. Nucleic acids 2021 Mar 5;23:944-958
Molecular therapy. Nucleic acids 2021 Mar 5;23:944-958
PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells.
Kang JW, Zhan Z, Ji G, Sang Y, Zhou D, Li Y, Feng H, Cheng T
Signal transduction and targeted therapy 2021 Mar 31;6(1):129
Signal transduction and targeted therapy 2021 Mar 31;6(1):129
ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling.
Cao LJ, Zhang YJ, Dong SQ, Li XZ, Tong XT, Chen D, Wu ZY, Zheng XH, Xue WQ, Jia WH, Zhang JB
Journal of experimental & clinical cancer research : CR 2021 Mar 23;40(1):109
Journal of experimental & clinical cancer research : CR 2021 Mar 23;40(1):109
Inhibitory activity of flavonoids from Ephedrae Herba on hypoxia signaling in PANC-1 cells and the evaluation of their mechanisms.
Yahagi H, Yahagi T, Matsumura M, Igarashi K, Yokoyama N, Matsuzaki K
Journal of natural medicines 2021 Jun;75(3):612-622
Journal of natural medicines 2021 Jun;75(3):612-622
Molecular Mechanism of Platelet-Derived Growth Factor (PDGF)-BB-Mediated Protection Against MPP(+) Toxicity in SH-SY5Y Cells.
Chen H, Teng Y, Liu Z, Geng F, Chen X, Jiang H, Yang J, Zheng M, Wang Z, Yang L
Journal of molecular neuroscience : MN 2021 Jun;71(6):1131-1143
Journal of molecular neuroscience : MN 2021 Jun;71(6):1131-1143
GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
Li SS, Chen DM, Chen LB, Wei H, Wang JL, Xiao J, Huang YH, Lian YF
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis.
Li W, Li Y, Guan Y, Du Y, Zhao M, Chen X, Zhu F, Guo C, Jia Y, Li Y, Wang X, Wang X, Shi Y, Wang Q, Li Y, Zhang L
Autophagy 2021 Jun;17(6):1410-1425
Autophagy 2021 Jun;17(6):1410-1425
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Li X, Wang X, Miao L, Guo Y, Yuan R, Tian H
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
Pan X, Zhao J, Zhou Z, Chen J, Yang Z, Wu Y, Bai M, Jiao Y, Yang Y, Hu X, Cheng T, Lu Q, Wang B, Li CL, Lu YJ, Diao L, Zhong YQ, Pan J, Zhu J, Xiao HS, Qiu ZL, Li J, Wang Z, Hui J, Bao L, Zhang X
eLife 2021 Jun 29;10
eLife 2021 Jun 29;10
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, Yang W, Mai Y, Liu R, Chen M, Dai C, Yang H, Lu J, Li H, Guan G, Huang M, Liu P, Li Z
Cell death & disease 2021 Jul 26;12(8):738
Cell death & disease 2021 Jul 26;12(8):738
Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP.
Chen Y, Hao Q, Wang S, Cao M, Huang Y, Weng X, Wang J, Zhang Z, He X, Lu H, Zhou X
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Spermidine at supraphysiological doses induces oxidative stress and granulosa cell apoptosis in mouse ovaries.
Jiang D, Jiang Y, Long S, Chen Z, Li Y, Mo G, Bai L, Hao X, Yan Y, Li L, Han C, Hu S, Zhao H, Kang B
Theriogenology 2021 Jul 1;168:25-32
Theriogenology 2021 Jul 1;168:25-32
Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats.
Liu H, Guo Y, Zhu R, Wang L, Chen B, Tian Y, Li R, Ma R, Jia Q, Zhang H, Xia B, Li Y, Wang X, Zhu X, Zhang R, Brӧmme D, Gao S, Zhang D, Pei X
Phytotherapy research : PTR 2021 Jan;35(1):424-441
Phytotherapy research : PTR 2021 Jan;35(1):424-441
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
Li S, Kuang M, Chen L, Li Y, Liu S, Du H, Cao L, You F
Cell reports 2021 Jan 19;34(3):108631
Cell reports 2021 Jan 19;34(3):108631
Identification of STXBP6-IRF1 positive feedback loop in regulation of PD-L1 in cancer.
Liu Y, Huang Z, Wei Y, Zhang M, Li X, Yang S, Wang H
Cancer immunology, immunotherapy : CII 2021 Feb;70(2):275-287
Cancer immunology, immunotherapy : CII 2021 Feb;70(2):275-287
Regulatory role of DEPTOR‑mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma.
Wang J, Chen J, Qiu D, Zeng Z
International journal of molecular medicine 2021 Feb;47(2):643-658
International journal of molecular medicine 2021 Feb;47(2):643-658
Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair.
Murray-Nerger LA, Justice JL, Rekapalli P, Hutton JE, Cristea IM
Nucleic acids research 2021 Feb 26;49(4):2044-2064
Nucleic acids research 2021 Feb 26;49(4):2044-2064
Abnormal nitration and S-sulfhydration modification of Sp1-CSE-H(2)S pathway trap the progress of hyperhomocysteinemia into a vicious cycle.
Luo C, Ji D, Li Y, Cao Y, Zhang S, Yan W, Xue K, Chai J, Wu Y, Liu H, Wang W
Free radical biology & medicine 2021 Feb 20;164:20-33
Free radical biology & medicine 2021 Feb 20;164:20-33
Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma.
Sarkar A, Stellrecht CM, Vangapandu HV, Ayres M, Kaipparettu BA, Park JH, Balakrishnan K, Burks JK, Pandita TK, Hittelman WN, Neelapu SS, Gandhi V
Haematologica 2021 Feb 1;106(2):495-512
Haematologica 2021 Feb 1;106(2):495-512
Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux.
Lu J, Lu J, Bu X, Li Y, Ge G, Guan S
Journal of food science 2021 Dec;86(12):5503-5515
Journal of food science 2021 Dec;86(12):5503-5515
Increased long noncoding RNA LINK-A contributes to rheumatoid synovial inflammation and aggression.
Wang J, Shen C, Li R, Wang C, Xiao Y, Kuang Y, Lao M, Xu S, Shi M, Cai X, Liang L, Xu H
JCI insight 2021 Dec 8;6(23)
JCI insight 2021 Dec 8;6(23)
Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis.
Zou Q, Yang L, Shi R, Qi Y, Zhang X, Qi H
iScience 2021 Dec 17;24(12):103396
iScience 2021 Dec 17;24(12):103396
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Wang Y, Jin R, Chen J, Cao J, Xiao J, Li X, Sun C
Food chemistry 2021 Dec 15;365:130470
Food chemistry 2021 Dec 15;365:130470
BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate.
Nagy A, Pethő D, Gesztelyi R, Juhász B, Balla G, Szilvássy Z, Balla J, Gáll T
International journal of molecular sciences 2021 Aug 26;22(17)
International journal of molecular sciences 2021 Aug 26;22(17)
The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus.
Zhang Y, Liu C, Wu B, Li L, Li W, Yuan L
Nature communications 2021 Aug 13;12(1):4926
Nature communications 2021 Aug 13;12(1):4926
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Zhang Y, Huang W, Zheng Z, Wang W, Yuan Y, Hong Q, Lin J, Li X, Meng Y
Free radical biology & medicine 2021 Apr;166:116-127
Free radical biology & medicine 2021 Apr;166:116-127
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation.
Xiao J, Xiong Y, Yang LT, Wang JQ, Zhou ZM, Dong LW, Shi XJ, Zhao X, Luo J, Song BL
Protein & cell 2021 Apr;12(4):279-296
Protein & cell 2021 Apr;12(4):279-296
Interaction of NEP with G Protein Pathway Suppressor 2 Facilitates Influenza A Virus Replication by Weakening the Inhibition of GPS2 to RNA Synthesis and Ribonucleoprotein Assembly.
Gong W, He X, Huang K, Zhang Y, Li C, Yang Y, Zou Z, Jin M
Journal of virology 2021 Apr 26;95(10)
Journal of virology 2021 Apr 26;95(10)
Discovering the Mechanisms of Wikstroelide E as a Potential HIV-Latency-Reversing Agent by Transcriptome Profiling.
Li SF, Liang X, Wu XK, Gao X, Zhang LW
Journal of natural products 2021 Apr 23;84(4):1022-1033
Journal of natural products 2021 Apr 23;84(4):1022-1033
Seco-type β-Apocarotenoid Generated by β-Carotene Oxidation Exerts Anti-inflammatory Effects against Activated Macrophages.
Takatani N, Beppu F, Yamano Y, Maoka T, Hosokawa M
Journal of oleo science 2021 Apr 2;70(4):549-558
Journal of oleo science 2021 Apr 2;70(4):549-558
Deletion of LBR N-terminal domains recapitulates Pelger-Huet anomaly phenotypes in mouse without disrupting X chromosome inactivation.
Young AN, Perlas E, Ruiz-Blanes N, Hierholzer A, Pomella N, Martin-Martin B, Liverziani A, Jachowicz JW, Giannakouros T, Cerase A
Communications biology 2021 Apr 12;4(1):478
Communications biology 2021 Apr 12;4(1):478
Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9(+) cells to prevent the development of liver cancer in a mouse model.
Chen M, Lu C, Lu H, Zhang J, Qin D, Liu S, Li X, Zhang L
Stem cell research & therapy 2021 Apr 12;12(1):232
Stem cell research & therapy 2021 Apr 12;12(1):232
Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator.
Chen YS, Chang HS, Hsiao HH, Chen YF, Kuo YP, Yen FL, Yen CH
Antioxidants (Basel, Switzerland) 2021 Apr 1;10(4)
Antioxidants (Basel, Switzerland) 2021 Apr 1;10(4)
Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.
Zhang T, Li H, Wang K, Xu B, Chen ZN, Bian H
Frontiers in cell and developmental biology 2020;8:784
Frontiers in cell and developmental biology 2020;8:784
β-Actin facilitates etoposide-induced p53 nuclear import.
Qi W, Li J, Pei X, Ke Y, Bu Q, Ni X
Journal of biosciences 2020;45
Journal of biosciences 2020;45
Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway.
Chen W, Yuan C, Lu Y, Zhu Q, Ma X, Xiao W, Gong W, Huang W, Xia Q, Lu G, Li W
Oxidative medicine and cellular longevity 2020;2020:5390482
Oxidative medicine and cellular longevity 2020;2020:5390482
Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway.
Li Y, Liu T, Li Y, Han D, Hong J, Yang N, He J, Peng R, Mi X, Kuang C, Zhou Y, Han Y, Shi C, Li Z, Guo X
Oxidative medicine and cellular longevity 2020;2020:4751349
Oxidative medicine and cellular longevity 2020;2020:4751349
Metformin Ameliorates Gestational Diabetes Mellitus-Induced Endothelial Dysfunction via Downregulation of p65 and Upregulation of Nrf2.
Sun CC, Lai YN, Wang WH, Xu XM, Li XQ, Wang H, Zheng JY, Zheng JQ
Frontiers in pharmacology 2020;11:575390
Frontiers in pharmacology 2020;11:575390
SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β-catenin signaling pathway.
Wang J, Ling R, Zhou Y, Gao X, Yang Y, Mao C, Chen D
Oncology letters 2020 Sep;20(3):2855-2869
Oncology letters 2020 Sep;20(3):2855-2869
Malic Enzyme 1 Is Associated with Tumor Budding in Oral Squamous Cell Carcinomas.
Nakashima C, Kirita T, Yamamoto K, Mori S, Luo Y, Sasaki T, Fujii K, Ohmori H, Kawahara I, Mori T, Goto K, Kishi S, Fujiwara-Tani R, Kuniyasu H
International journal of molecular sciences 2020 Sep 28;21(19)
International journal of molecular sciences 2020 Sep 28;21(19)
Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway.
Zheng J, Tian J, Wang S, Hu P, Wu Q, Shan X, Zhao P, Zhang C, Guo W, Xu M, Chen H, Lu R
European journal of pharmacology 2020 Sep 15;883:173386
European journal of pharmacology 2020 Sep 15;883:173386
Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells.
Miyamoto M, Sawada K, Nakamura K, Yoshimura A, Ishida K, Kobayashi M, Shimizu A, Yamamoto M, Kodama M, Hashimoto K, Kimura T
Scientific reports 2020 Oct 7;10(1):16755
Scientific reports 2020 Oct 7;10(1):16755
Evaluation of cancer-derived myocardial impairments using a mouse model.
Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
Oncotarget 2020 Oct 13;11(41):3712-3722
Oncotarget 2020 Oct 13;11(41):3712-3722
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Dai W, Xu L, Yu X, Zhang G, Guo H, Liu H, Song G, Weng S, Dong L, Zhu J, Liu T, Guo C, Shen X
Journal of hepatology 2020 May;72(5):909-923
Journal of hepatology 2020 May;72(5):909-923
Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice.
Hoshi M, Osawa Y, Nakamoto K, Morita N, Yamamoto Y, Ando T, Tashita C, Nabeshima T, Saito K
Toxicology 2020 May 30;438:152458
Toxicology 2020 May 30;438:152458
Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer.
Rai R, Gong Essel K, Mangiaracina Benbrook D, Garland J, Daniel Zhao Y, Chandra V
Cancers 2020 May 18;12(5)
Cancers 2020 May 18;12(5)
Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis.
Zhao M, Shen L, Ouyang Z, Li M, Deng G, Yang C, Zheng W, Kong L, Wu X, Wu X, Guo W, Yin Y, Xu Q, Sun Y
Journal of molecular cell biology 2020 May 18;12(4):277-290
Journal of molecular cell biology 2020 May 18;12(4):277-290
Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity.
Xu J, Chen Y, Yang R, Zhou T, Ke W, Si Y, Yang S, Zhang T, Liu X, Zhang L, Xiang K, Guo Y, Liu Y
Archives of biochemistry and biophysics 2020 May 15;684:108314
Archives of biochemistry and biophysics 2020 May 15;684:108314
Arsenic trioxide induces gasdermin E mediated pyroptosis in astroglioma cells.
Wang J, Zhan L, Cai Z, Liu X, Wang J, Zhong H, Huang X, Lai Q, Tan Q, Xiu Y, Yang D, Min X
Translational cancer research 2020 Mar;9(3):1926-1930
Translational cancer research 2020 Mar;9(3):1926-1930
23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9.
Li HH, Li J, Zhang XJ, Li JM, Xi C, Wang WQ, Lu YL, Xuan LJ
Acta pharmacologica Sinica 2020 Mar;41(3):327-335
Acta pharmacologica Sinica 2020 Mar;41(3):327-335
Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Schwartz S, Santarelli F, Gieselmann V, Klockgether T, Brosseron F, Heneka MT
Journal of neurochemistry 2020 Mar;152(6):710-726
Journal of neurochemistry 2020 Mar;152(6):710-726
Polymorphisms in Human APOBEC3H Differentially Regulate Ubiquitination and Antiviral Activity.
Chesarino NM, Emerman M
Viruses 2020 Mar 30;12(4)
Viruses 2020 Mar 30;12(4)
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Liu J, Tan Y, Yang B, Wu Y, Fan B, Zhu S, Song E, Song Y
Environment international 2020 Jun;139:105701
Environment international 2020 Jun;139:105701
Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging.
Sasik MUT, Eravsar ETK, Kinali M, Ergul AA, Adams MM
Neuroscience 2020 Jun 1;436:46-73
Neuroscience 2020 Jun 1;436:46-73
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma.
Wang SJ, Chao D, Wei W, Nan G, Li JY, Liu FL, Li L, Jiang JL, Cui HY, Chen ZN
Journal of experimental & clinical cancer research : CR 2020 Jul 29;39(1):145
Journal of experimental & clinical cancer research : CR 2020 Jul 29;39(1):145
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Dong Y, Xing Y, Sun J, Sun W, Xu Y, Quan C
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABA(A) receptors.
Teoh J, Subramanian N, Pero ME, Bartolini F, Amador A, Kanber A, Williams D, Petri S, Yang M, Allen AS, Beal J, Haut SR, Frankel WN
Neurobiology of disease 2020 Feb;134:104632
Neurobiology of disease 2020 Feb;134:104632
Oncogenic role of TYRO3 receptor tyrosine kinase in the progression of pancreatic cancer.
Morimoto M, Horikoshi Y, Nakaso K, Kurashiki T, Kitagawa Y, Hanaki T, Sakamoto T, Honjo S, Umekita Y, Fujiwara Y, Matsura T
Cancer letters 2020 Feb 1;470:149-160
Cancer letters 2020 Feb 1;470:149-160
Ribosome 18S m(6)A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.
Rong B, Zhang Q, Wan J, Xing S, Dai R, Li Y, Cai J, Xie J, Song Y, Chen J, Zhang L, Yan G, Zhang W, Gao H, Han JJ, Qu Q, Ma H, Tian Y, Lan F
Cell reports 2020 Dec 22;33(12):108544
Cell reports 2020 Dec 22;33(12):108544
Tet2 regulates Barx2 expression in undifferentiated and early differentiated mouse embryonic stem cells.
Qiao Z, Zhang S, Hu T, Lan F, Yu D, Ge G, Li C, Fang S, Chen Q
Biochemical and biophysical research communications 2020 Dec 17;533(4):1212-1218
Biochemical and biophysical research communications 2020 Dec 17;533(4):1212-1218
The vulnerability of motor and frontal cortex-dependent behaviors in mice expressing ALS-linked mutation in TDP-43.
Wong P, Ho WY, Yen YC, Sanford E, Ling SC
Neurobiology of aging 2020 Aug;92:43-60
Neurobiology of aging 2020 Aug;92:43-60
BPTES inhibits anthrax lethal toxin-induced inflammatory response.
Wang J, Yang D, Shen X, Wang J, Liu X, Lin J, Zhong J, Zhao Y, Qi Z
International immunopharmacology 2020 Aug;85:106664
International immunopharmacology 2020 Aug;85:106664
Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly.
Li Y, Li M, Weigel B, Mall M, Werth VP, Liu ML
EMBO reports 2020 Aug 5;21(8):e48779
EMBO reports 2020 Aug 5;21(8):e48779
Effects of peptidoglycan on the development of steatohepatitis.
Jin M, Lai Y, Zhao P, Shen Q, Su W, Yin Y, Zhang W
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Apr;1865(4):158595
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Apr;1865(4):158595
OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3.
Zhang Z, Wang D, Wang P, Zhao Y, You F
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 1;204(7):1904-1918
Journal of immunology (Baltimore, Md. : 1950) 2020 Apr 1;204(7):1904-1918
CACYBP Enhances Cytoplasmic Retention of P27(Kip1) to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation.
Lian YF, Huang YL, Zhang YJ, Chen DM, Wang JL, Wei H, Bi YH, Jiang ZW, Li P, Chen MS, Huang YH
Theranostics 2019;9(26):8392-8408
Theranostics 2019;9(26):8392-8408
Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage.
Ye J, Luo D, Xu X, Sun M, Su X, Tian Z, Zhang M, Yu C, Guan Q
Oxidative medicine and cellular longevity 2019;2019:9151067
Oxidative medicine and cellular longevity 2019;2019:9151067
Deficiency of emerin contributes differently to the pathogenesis of skeletal and cardiac muscles in LmnaH222P/H222P mutant mice.
Wada E, Kato M, Yamashita K, Kokuba H, Liang WC, Bonne G, Hayashi YK
PloS one 2019;14(8):e0221512
PloS one 2019;14(8):e0221512
Nigericin Promotes NLRP3-Independent Bacterial Killing in Macrophages.
Armstrong H, Bording-Jorgensen M, Chan R, Wine E
Frontiers in immunology 2019;10:2296
Frontiers in immunology 2019;10:2296
Zinc Inhibits HIF-Prolyl Hydroxylase Inhibitor-Aggravated VSMC Calcification Induced by High Phosphate.
Nagy A, Pethő D, Gáll T, Zavaczki E, Nyitrai M, Posta J, Zarjou A, Agarwal A, Balla G, Balla J
Frontiers in physiology 2019;10:1584
Frontiers in physiology 2019;10:1584
Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P(2) and extended synaptotagmins.
Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X, Song BL
Science China. Life sciences 2019 Sep;62(9):1117-1135
Science China. Life sciences 2019 Sep;62(9):1117-1135
Probiotic effect on Helicobacter pylori attachment and inhibition of inflammation in human gastric epithelial cells.
Song H, Zhou L, Liu D, Ge L, Li Y
Experimental and therapeutic medicine 2019 Sep;18(3):1551-1562
Experimental and therapeutic medicine 2019 Sep;18(3):1551-1562
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
Sang Y, Li Y, Zhang Y, Alvarez AA, Yu B, Zhang W, Hu B, Cheng SY, Feng H
Nature communications 2019 Sep 5;10(1):4013
Nature communications 2019 Sep 5;10(1):4013
ACLY facilitates colon cancer cell metastasis by CTNNB1.
Wen J, Min X, Shen M, Hua Q, Han Y, Zhao L, Liu L, Huang G, Liu J, Zhao X
Journal of experimental & clinical cancer research : CR 2019 Sep 12;38(1):401
Journal of experimental & clinical cancer research : CR 2019 Sep 12;38(1):401
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers.
Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F
Cell host & microbe 2019 Sep 11;26(3):369-384.e8
Cell host & microbe 2019 Sep 11;26(3):369-384.e8
Arp2/3-Branched Actin Maintains an Active Pool of GTP-RhoA and Controls RhoA Abundance.
Huang Y, Yi X, Kang C, Wu C
Cells 2019 Oct 16;8(10)
Cells 2019 Oct 16;8(10)
USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.
Ting X, Xia L, Yang J, He L, Si W, Shang Y, Sun L
Nucleic acids research 2019 Oct 10;47(18):9721-9740
Nucleic acids research 2019 Oct 10;47(18):9721-9740
The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING.
Wang P, Li S, Zhao Y, Zhang B, Li Y, Liu S, Du H, Cao L, Ou M, Ye X, Li P, Gao X, Wang P, Jing C, Shao F, Yang G, You F
The Journal of biological chemistry 2019 Nov 8;294(45):16494-16508
The Journal of biological chemistry 2019 Nov 8;294(45):16494-16508
The phosphorylation of Tudor-SN mediated by JNK is involved in the regulation of milk protein synthesis induced by prolactin in BMECs.
Zhang S, Qi H, Wen XP, Li P, Gao XJ, Ao JX
Journal of cellular physiology 2019 May;234(5):6077-6090
Journal of cellular physiology 2019 May;234(5):6077-6090
Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
Yang C, Lu M, Chen W, He Z, Hou X, Feng M, Zhang H, Bo T, Zhou X, Yu Y, Zhang H, Zhao M, Wang L, Yu C, Gao L, Jiang W, Zhang Q, Zhao J
The Journal of experimental medicine 2019 May 6;216(5):1182-1198
The Journal of experimental medicine 2019 May 6;216(5):1182-1198
Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport.
Ma H, Liu Z, Zhong CQ, Liu Y, Zhang Z, Liang Y, Li J, Han S, Han J
Molecular and cellular biology 2019 May 1;39(9)
Molecular and cellular biology 2019 May 1;39(9)
S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells.
Tsuneyoshi T, Kunimura K, Morihara N
Nitric oxide : biology and chemistry 2019 Mar 1;84:22-29
Nitric oxide : biology and chemistry 2019 Mar 1;84:22-29
Multi-omic Analyses Reveal Minimal Impact of the CRISPR-Cas9 Nuclease on Cultured Human Cells.
Qiang J, Ma Z, Xie X, Shi L, Geng Y, Hu J, Liu R, Liu N, Zhang Y
Journal of proteome research 2019 Mar 1;18(3):1054-1063
Journal of proteome research 2019 Mar 1;18(3):1054-1063
Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways.
Shen B, Zhao C, Wang Y, Peng Y, Cheng J, Li Z, Wu L, Jin M, Feng H
Journal of cellular and molecular medicine 2019 Jun;23(6):4063-4075
Journal of cellular and molecular medicine 2019 Jun;23(6):4063-4075
NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ.
Luan P, Jian W, Xu X, Kou W, Yu Q, Hu H, Li D, Wang W, Feinberg MW, Zhuang J, Xu Y, Peng W
Nature communications 2019 Jun 28;10(1):2882
Nature communications 2019 Jun 28;10(1):2882
Atractylodin ameliorates lipopolysaccharide and d-galactosamine-induced acute liver failure via the suppression of inflammation and oxidative stress.
Lyu Z, Ji X, Chen G, An B
International immunopharmacology 2019 Jul;72:348-357
International immunopharmacology 2019 Jul;72:348-357
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-κB and activating Nrf2/HO-1 signaling pathways.
Li Z, Feng H, Wang Y, Shen B, Tian Y, Wu L, Zhang Q, Jin M, Liu G
International immunopharmacology 2019 Feb;67:465-472
International immunopharmacology 2019 Feb;67:465-472
The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Wang Y, Chen Y, Chen J, Wang L, Nie L, Long J, Chang H, Wu J, Huang C, Lei M
Nature communications 2019 Feb 4;10(1):564
Nature communications 2019 Feb 4;10(1):564
SUMOylation is required for PIPK1γ-driven keratinocyte migration and growth.
Ni W, Li Y, Cai L, Dong C, Fang H, Chen Y, Li H, Yao M, Xiao N
The FEBS journal 2019 Dec;286(23):4709-4720
The FEBS journal 2019 Dec;286(23):4709-4720
Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation.
Zhou YH, Sun L, Chen J, Sun WW, Ma L, Han Y, Jin X, Zhao QX, Li T, Lu H, Qiu X, Wang JH
mBio 2019 Dec 17;10(6)
mBio 2019 Dec 17;10(6)
Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.
Binning JM, Chesarino NM, Emerman M, Gross JD
Cell host & microbe 2019 Dec 11;26(6):739-747.e4
Cell host & microbe 2019 Dec 11;26(6):739-747.e4
Fibrinopeptide A induces C-reactive protein expression through the ROS-ERK1/2/p38-NF-κB signal pathway in the human umbilical vascular endothelial cells.
Zhao J, Xu SZ, Liu J
Journal of cellular physiology 2019 Aug;234(8):13481-13492
Journal of cellular physiology 2019 Aug;234(8):13481-13492
Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.
Zheng J, Fan R, Wu H, Yao H, Yan Y, Liu J, Ran L, Sun Z, Yi L, Dang L, Gan P, Zheng P, Yang T, Zhang Y, Tang T, Wang Y
Nature communications 2019 Apr 8;10(1):1604
Nature communications 2019 Apr 8;10(1):1604
Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation.
Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, Tong X, Chen L, Liu X, Zhang Y, Zhu X, Li X, Zhang H, Bai H, Yang Q, Ma J, Wiemer EAC, Xu Y, Chen Q
Nature communications 2019 Apr 17;10(1):1801
Nature communications 2019 Apr 17;10(1):1801
Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts.
Wei H, Lin L, Zhang X, Feng Z, Wang Y, You Y, Wang X, Hou Y
Biological research 2019 Apr 16;52(1):23
Biological research 2019 Apr 16;52(1):23
Asiatic Acid (AA) Sensitizes Multidrug-Resistant Human Lung Adenocarcinoma A549/DDP Cells to Cisplatin (DDP) via Downregulation of P-Glycoprotein (MDR1) and Its Targets.
Cheng Q, Liao M, Hu H, Li H, Wu L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):279-292
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):279-292
NLRP12 Promotes Mouse Neutrophil Differentiation through Regulation of Non-canonical NF-κB and MAPK(ERK1/2) Signaling.
Wang Q, Liu F, Zhang M, Zhou P, Xu C, Li Y, Bian L, Liu Y, Yao Y, Wang F, Fang Y, Li D
International journal of biological sciences 2018;14(2):147-155
International journal of biological sciences 2018;14(2):147-155
Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway.
Zhang M, Ding G, Zhou L, Shen T, Xu X, Zhao T, Jia S, Cao L
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Sep;38(9):413-422
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Sep;38(9):413-422
TET2 inhibits tumorigenesis of breast cancer cells by regulating caspase-4.
Zhu X, Li S
Scientific reports 2018 Nov 1;8(1):16167
Scientific reports 2018 Nov 1;8(1):16167
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.
Yang JY, Deng XY, Li YS, Ma XC, Feng JX, Yu B, Chen Y, Luo YL, Wang X, Chen ML, Fang ZX, Zheng FX, Li YP, Zhong Q, Kang TB, Song LB, Xu RH, Zeng MS, Chen W, Zhang H, Xie W, Gao S
Nature communications 2018 Mar 21;9(1):1165
Nature communications 2018 Mar 21;9(1):1165
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Molecular cell 2018 Mar 15;69(6):1028-1038.e6
Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway.
Liu W, Zhao Z, Wang Y, Li W, Su Q, Jia Q, Zhang J, Zhang X, Shen J, Yin J
Cell death & disease 2018 Mar 1;9(3):343
Cell death & disease 2018 Mar 1;9(3):343
Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling.
Ren J, Jian F, Jiang H, Sun Y, Pan S, Gu C, Chen X, Wang W, Ning G, Bian L, Sun Q
International journal of oncology 2018 Jun;52(6):1934-1946
International journal of oncology 2018 Jun;52(6):1934-1946
Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.
Pu D, Zhao Y, Chen J, Sun Y, Lv A, Zhu S, Luo C, Zhao K, Xiao Q
Neuroscience 2018 Jun 15;381:35-45
Neuroscience 2018 Jun 15;381:35-45
Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress.
Lu M, Wu J, Hao ZW, Shang YK, Xu J, Nan G, Li X, Chen ZN, Bian H
Hepatology (Baltimore, Md.) 2018 Jul;68(1):317-332
Hepatology (Baltimore, Md.) 2018 Jul;68(1):317-332
The E3 ubiquitin ligase MuRF2 attenuates LPS-induced macrophage activation by inhibiting production of inflammatory cytokines and migration.
Bian H, Gao S, Zhang D, Zhao Q, Li F, Li X, Sun S, Song S, Li T, Zhu Q, Ren W, Qin C, Qi J
FEBS open bio 2018 Feb;8(2):234-243
FEBS open bio 2018 Feb;8(2):234-243
Radix Salviae miltiorrhizae improves bone microstructure and strength through Wnt/β-catenin and osteoprotegerin/receptor activator for nuclear factor-κB ligand/cathepsin K signaling in ovariectomized rats.
Liu H, Zhu R, Wang L, Liu C, Ma R, Qi B, Chen B, Li L, Guo Y, Shi S, Jia Q, Niu J, Zhao D, Mo F, Gao S, Zhang D
Phytotherapy research : PTR 2018 Dec;32(12):2487-2500
Phytotherapy research : PTR 2018 Dec;32(12):2487-2500
Twist1 Enhances Hypoxia Induced Radioresistance in Cervical Cancer Cells by Promoting Nuclear EGFR Localization.
Xiong H, Nie X, Zou Y, Gong C, Li Y, Wu H, Qiu H, Yang L, Zhuang L, Zhang P, Zhang J, Wang Y, Xiong H
Journal of Cancer 2017;8(3):345-353
Journal of Cancer 2017;8(3):345-353
KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer.
Jia S, Qu T, Wang X, Feng M, Yang Y, Feng X, Ma R, Li W, Hu Y, Feng Y, Ji K, Li Z, Jiang W, Ji J
PloS one 2017;12(4):e0175058
PloS one 2017;12(4):e0175058
MTEP impedes the neuronal polarization and the activity of the Akt-NF-κB pathway in rat hippocampal neurons.
Zhang X, Hu M, Zhang L, An J, Yan W, Zhang Z, Liu J, Lu H, Chen X, Liu Y
Journal of neuroscience research 2017 Sep;95(9):1730-1744
Journal of neuroscience research 2017 Sep;95(9):1730-1744
Quercetin protects against atherosclerosis by inhibiting dendritic cell activation.
Lin W, Wang W, Wang D, Ling W
Molecular nutrition & food research 2017 Sep;61(9)
Molecular nutrition & food research 2017 Sep;61(9)
Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags.
Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Kummer MP, Brosseron F, Gieselmann V, Heneka MT
Journal of neuroscience methods 2017 Nov 1;291:95-100
Journal of neuroscience methods 2017 Nov 1;291:95-100
Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2.
Li Y, Wang L, Zhou L, Song Y, Ma S, Yu C, Zhao J, Xu C, Gao L
Molecular and cellular endocrinology 2017 May 5;446:70-80
Molecular and cellular endocrinology 2017 May 5;446:70-80
Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.
Zhang C, Mao HL, Cao Y
Scientific reports 2017 Jun 19;7(1):3769
Scientific reports 2017 Jun 19;7(1):3769
Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy.
Wu B, Cui J, Yang XM, Liu ZY, Song F, Li L, Jiang JL, Chen ZN
Cell death & disease 2017 Jul 13;8(7):e2925
Cell death & disease 2017 Jul 13;8(7):e2925
HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.
Huang Q, Niu Z, Han J, Liu X, Lv Z, Li H, Yuan L, Li X, Sun S, Wang H, Huang X
Oncotarget 2017 Aug 1;8(31):51123-51133
Oncotarget 2017 Aug 1;8(31):51123-51133
The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription.
Xiang N, He M, Ishaq M, Gao Y, Song F, Guo L, Ma L, Sun G, Liu D, Guo D, Chen Y
PloS one 2016;11(10):e0164471
PloS one 2016;11(10):e0164471
The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.
Koidl S, Eisenhardt N, Fatouros C, Droescher M, Chaugule VK, Pichler A
The international journal of biochemistry & cell biology 2016 Oct;79:478-487
The international journal of biochemistry & cell biology 2016 Oct;79:478-487
HMGB1 Enhances Drug Resistance and Promotes In Vivo Tumor Growth of Lung Cancer Cells.
Zheng H, Chen JN, Yu X, Jiang P, Yuan L, Shen HS, Zhao LH, Chen PF, Yang M
DNA and cell biology 2016 Oct;35(10):622-627
DNA and cell biology 2016 Oct;35(10):622-627
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, Xu J, Tian D
Scientific reports 2016 Jun 8;6:27597
Scientific reports 2016 Jun 8;6:27597
Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation.
Nie D, Zhang D, Dai J, Zhang M, Zhao X, Xu W, Chen Z, Wang L, Wang Z, Qiao Z
Biology of reproduction 2016 Feb;94(2):31
Biology of reproduction 2016 Feb;94(2):31
The long noncoding RNA ASNR regulates degradation of Bcl-2 mRNA through its interaction with AUF1.
Chen J, Liu L, Wei G, Wu W, Luo H, Yuan J, Luo J, Chen R
Scientific reports 2016 Aug 31;6:32189
Scientific reports 2016 Aug 31;6:32189
Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity.
Wu J, Guo W, Lin SZ, Wang ZJ, Kan JT, Chen SY, Zhu YZ
Cell death & disease 2016 Aug 18;7(8):e2339
Cell death & disease 2016 Aug 18;7(8):e2339
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
Dong Y, Ye W, Yang J, Han P, Wang Y, Ye C, Weng D, Zhang F, Xu Z, Lei Y
Biochemical and biophysical research communications 2016 Apr 29;473(2):648-53
Biochemical and biophysical research communications 2016 Apr 29;473(2):648-53
Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice.
Chen H, Sun Y, Lai L, Wu H, Xiao Y, Ming B, Gao M, Zou H, Xiong P, Xu Y, Tan Z, Gong F, Zheng F
Neuroscience 2015 Nov 12;308:157-68
Neuroscience 2015 Nov 12;308:157-68
Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via nuclear factor-κB activation.
Liu H, Wang ZC, Bai YG, Cai Y, Yu JW, Zhang HJ, Bao JX, Ren XL, Xie MJ, Ma J
Clinical and experimental pharmacology & physiology 2015 May;42(5):510-9
Clinical and experimental pharmacology & physiology 2015 May;42(5):510-9
Astrocyte elevated gene-1 promotes progression of cervical squamous cell carcinoma by inducing epithelial-mesenchymal transition via Wnt signaling.
Song E, Yu W, Xiong X, Kuang X, Ai Y, Xiong X
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2015 Mar;25(3):345-55
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2015 Mar;25(3):345-55
Rho GDIalpha Modulates Rabbit Trophoblast Stem Cell Survival and Migration.
Zhang J, Li T, Ji W, Yu Y, Tan T
Biology of reproduction 2015 Dec;93(6):144
Biology of reproduction 2015 Dec;93(6):144
Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication.
Bai L, Zhang W, Tan L, Yang H, Ge M, Zhu C, Zhang R, Cao Y, Chen J, Luo Z, Ho W, Liu F, Wu K, Wu J
Journal of molecular cell biology 2015 Dec;7(6):543-56
Journal of molecular cell biology 2015 Dec;7(6):543-56
Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells.
Chen L, Zhang W, Liang HF, Zhou QF, Ding ZY, Yang HQ, Liu WB, Wu YH, Man Q, Zhang BX, Chen XP
Cell communication and signaling : CCS 2014 Mar 17;12:18
Cell communication and signaling : CCS 2014 Mar 17;12:18
Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells.
Tan T, Lu B, Zhang J, Niu Y, Si W, Wei Q, Ji W
Stem cells and development 2014 Apr 15;23(8):813-22
Stem cells and development 2014 Apr 15;23(8):813-22
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Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Lamin B1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human Lamin B1. This antibody recognizes human,mouse,rat antigen. The Lamin B1 antibody has been validated for the following applications: ELISA, WB, IF, FC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Western blot on multiple cells/tissues with anti-LMNB1 (66095-1-Ig) at dilution 1:20000.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells using 66095-1-Ig( Lamin B1 Antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
