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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [180]
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- Product number
- 66301-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- LAMP2 antibody
- Antibody type
- Monoclonal
- Description
- LAMP2 antibody (Cat. #66301-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, pig and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgA
- Antibody clone number
- 2D3B9
- Vial size
- 20ul, 150ul
Submitted references Chronic intermittent hypoxia increases Parkinson's disease susceptibility via PPARα-mediated lipid droplet-mitochondrial dysfunction.
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles.
PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma.
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.
Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis.
Numb attenuates LPS-induced neuroinflammation via autophagic regulation of Ifi204 in microglia.
Cathepsin B regulated via TFEB and lysosomal membrane permeabilization in adipose tissue macrophages aggravates obesity-related severe acute pancreatitis.
CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7-Positive Vesicle Fusion with Target Membranes.
Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization, and bleeding is a major defect in Alzheimer's disease.
Targeting the HDAC4-NHE6-endosomal pH axis restores amyloid-β clearance and cognitive function in Alzheimer's disease mice.
Stabilizing MARCH7 as a ferro-guardian against ferroptosis.
NDST3 suppression restores lysosomal acidification and ameliorates amyloid-β and MAPT/tau pathology in Alzheimer's disease.
ANXA2-mediated Phagocytosis Generates AR(+) Macrophages to Confer Enzalutamide Resistance in Prostate Cancer.
Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson's disease pathogenesis.
Fenofibrate suppresses Mycoplasma bovis infection via autophagy-mediated cholesterol regulation in bovine mammary epithelial cells and murine mammary tissue.
The lysosome-associated SLAMF7 inhibits the development of ovarian cancer by promoting lysosomal damage.
Enhanced autophagic clearance of amyloid-β via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo.
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
Dimethyl malonate preserves brain and neurobehavioral phenotype following neonatal hypoxia-ischemia by inhibiting FTH1-mediated ferritinophagy.
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
UBE2D2 promotes gastric cancer progression by inhibiting ferroptosis through autophagy-dependent stabilization of CST1.
SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness.
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Lysosomal homeostasis regulates myocardial ischemia-reperfusion injury through autophagy pathway.
Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal.
Role of neuroglia cell-derived microvesicles in cobalt chloride-induced mitochondrial autophagy in neurons.
RIOK2 kinase regulates the translocation of the FADD-RIPK1-Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis.
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy.
Liensinine overcomes EGFR-TKI resistance in lung adenocarcinoma through DRP1-mediated autophagy.
PCSK9 promotes progression of anaplastic thyroid cancer through E-cadherin endocytosis.
Cadmium-induced disruption of exosomal secretion and cellular pathways in leydig cells.
Oral exposure to nanoplastics altered lipid profiles in mouse intestine.
USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3.
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex.
ATP6AP1 promotes cell proliferation and tamoxifen resistance in luminal breast cancer by inducing autophagy.
MTHFD2 Enhances cMYC O-GlcNAcylation to Promote Sunitinib Resistance in Renal Cell Carcinoma.
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV.
Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules.
Palmitoylation enhances the stability of porcine epidemic diarrhea virus spike protein by antagonizing its degradation via chaperone-mediated autophagy to facilitate viral proliferation.
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
Visualizing bulk autophagy in vivo by tagging endogenous LC3B.
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy.
TBBPA-BDBPE induces ferroptosis in trophoblasts through chaperone-mediated autophagy of GPX4.
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism.
Polymeric Polylactic Acid-Glycolic Acid-Based Nanoparticles Deliver Nintedanib Across the Blood-Brain Barrier to Inhibit Glioblastoma Growth.
Dapagliflozin and Sirtuin-1 interaction and mechanism for ameliorating atrial fibrillation in a streptozotocin-induced rodent diabetic model.
Targeting on the PI3K/mTOR: a potential treatment strategy for clear cell ovarian carcinoma.
Investigation of oral toxicity of WS(2) nanosheets to mouse intestine: Pathological injury, trace element balance, lipid profile changes, and autophagy.
Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.
Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15.
Rab7-regulated ferroptosis contributes to tubular epithelial cells injury by degradation of GPX4 via chaperone-mediated autophagy in AKI.
Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti-Inflammation in Diabetic Wounds.
α-hederin decreases the glycolysis level in intestinal epithelial cells via SNX10-mediated DEPDC5 degradation.
Impaired lipolysis and mitochondrial dysfunction in the epididymal tissues of high-fat diet-fed mice.
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice.
Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning.
Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease.
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux.
NLRP12 decreases TRIM25-mediated HK2 degradation to promote glycolysis and H3K18la in gastric cancer.
Mycoplasma ovipnuemoniae impairs the immune response of sheep and suppresses neutrophil function by inhibiting S100A9.
Design, Synthesis, and Biological Evaluation of Naphthalimide-Polyamine Conjugate as a Potential Anti-Colorectal Cancer Agent.
SNX10 Is Involved in Ovarian Cancer Cell Metastasis by Repolarizing Tumor-Associated Macrophages Through mTOR1/Lysosomes Pathway.
St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.
Qingre Huoxue decoction attenuates myocardial ischemia‒reperfusion injury by regulating the autophagy‒endoplasmic reticulum stress axis via FAM134B-mediated ER-phagy.
Novel mechanistic study of HDAC6 regulation of rheumatoid arthritis via CMA: exploring potential therapeutic targets.
MK8722 initiates early-stage autophagy while inhibiting late-stage autophagy via FASN-dependent reprogramming of lipid metabolism.
CTCF-activated FUCA1 functions as a tumor suppressor by promoting autophagy flux and serum α-L-fucosidase serves as a potential biomarker for prognosis in ccRCC.
Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis.
The novel lnc-HZ12 suppresses autophagy degradation of BBC3 by preventing its interactions with HSPA8 to induce trophoblast cell apoptosis.
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
Alcohol promotes hepatocyte injury via ER stress sensor XBP1s mediated regulation of autophagy and lysosomal activity.
COPZ1 regulates ferroptosis through NCOA4-mediated ferritinophagy in lung adenocarcinoma.
Porcine reproductive and respiratory syndrome virus degrades TANK-binding kinase 1 via chaperon-mediated autophagy to suppress type I interferon production and facilitate viral proliferation.
Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization.
Normal transferrin glycosylation does not rule out severe ALG1 deficiency.
Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy.
Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion.
TRIM65 promotes renal cell carcinoma through ubiquitination and degradation of BTG3.
Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway.
HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells.
ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis.
GLA Mutations Suppress Autophagy and Stimulate Lysosome Generation in Fabry Disease.
A pan-KRAS degrader for the treatment of KRAS-mutant cancers.
Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis.
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes.
Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.
Overexpression of SESN1 improves mitochondrial damage and mitophagy, a potential therapeutic strategy for cognitive dysfunction after anaesthesia.
TRPML1 contributes to antimony-induced nephrotoxicity by initiating ferroptosis via chaperone-mediated autophagy.
Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation.
A Novel Cargo Delivery System-AnCar-Exo(LaIMTS) Ameliorates Arthritis via Specifically Targeting Pro-Inflammatory Macrophages.
Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway.
Shaoyao-Gancao Decoction, a famous Chinese medicine formula, protects against APAP-induced liver injury by promoting autophagy/mitophagy.
The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα.
Restoration of miR-299-3p promotes efferocytosis and ameliorates atherosclerosis via repressing CD47 in mice.
Optogenetic manipulation of lysosomal physiology and autophagy-dependent clearance of amyloid beta.
Dysregulation of Autophagy Occurs During Congenital Cataract Development in βA3ΔG91 Mice.
Identification and analysis of type 2 diabetes-mellitus-associated autophagy-related genes.
TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.
WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury.
Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis.
Porcine deltacoronavirus accessory protein NS6 harnesses VPS35-mediated retrograde trafficking to facilitate efficient viral infection.
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress.
Mitophagy and mitochondrion-related expression profiles in response to physiological and pathological hypoxia in the corneal epithelium.
RAB7A GTPase Is Involved in Mitophagosome Formation and Autophagosome-Lysosome Fusion in N2a Cells Treated with the Prion Protein Fragment 106-126.
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition.
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation.
Autophagy and exosomes coordinately mediate quercetin's protective effects on alcoholic liver disease.
The human discs large protein 1 interacts with and maintains connexin 43 at the plasma membrane in keratinocytes.
Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy.
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics.
Zhachong Shisanwei Pill resists ischemic stroke by lysosome pathway based on proteomics and bioinformatics.
Impaired autophagy flux by lncRNA NEAT1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment.
Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.
Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes.
Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.
Corilagin attenuates intestinal ischemia/reperfusion injury in mice by inhibiting ferritinophagy-mediated ferroptosis through disrupting NCOA4-ferritin interaction.
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis.
Cadmium-induced impairment of spermatozoa development by reducing exosomal-MVBs secretion: a novel pathway.
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in Nonsmall-Cell Lung Cancer.
Prototheca bovis induces autophagy in bovine mammary epithelial cells via the HIF-1α and AMPKα/ULK1 pathway.
YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis.
RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux.
The effect of aerobic exercise on the lipophagy of adipose tissue in obese male mice.
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.
YAP1 protects against septic liver injury via ferroptosis resistance.
Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy.
Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy.
Ppt1-deficiency dysregulates lysosomal Ca(++) homeostasis contributing to pathogenesis in a mouse model of CLN1 disease.
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Progranulin Insufficiency Affects Lysosomal Homeostasis in Retinal Pigment Epithelium.
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
SUMO2-mediated SUMOylation of SH3GLB1 promotes ionizing radiation-induced hypertrophic cardiomyopathy through mitophagy activation.
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.
PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer.
Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.
Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction.
Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages.
GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis.
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
PINK1 Alleviates Cognitive Impairments via Attenuating Pathological Tau Aggregation in a Mouse Model of Tauopathy.
Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta.
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment.
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH.
CLEC5A knockdown protects against cardiac dysfunction after myocardial infarction by suppressing macrophage polarization, NLRP3 inflammasome activation, and pyroptosis.
Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.
Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR-p70S6K pathway.
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Fatty acid binding protein 3 deficiency limits atherosclerosis development via macrophage foam cell formation inhibition.
Inhibition of Autophagy Suppresses SARS-CoV-2 Replication and Ameliorates Pneumonia in hACE2 Transgenic Mice and Xenografted Human Lung Tissues.
Glucose-induced decrease of cystathionine β-synthase mediates renal injuries.
Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
Atmospheric particulate matter impedes autophagic flux by impairing lysosomal milieu and integrity in human umbilical vein endothelial cells (HUVECs).
Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca(2+)/CaMKII signal pathway.
Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy.
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI.
Mutation analysis of MFSD8 in an amyotrophic lateral sclerosis cohort from mainland China.
Classical swine fever virus infection suppresses claudin-1 expression to facilitate its replication in PK-15 cells.
Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Butyrate-mediated autophagy inhibition limits cytosolic Salmonella Infantis replication in the colon of pigs treated with a mixture of Lactobacillus and Bacillus.
TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.
Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance.
Zhai MR, Pan J, Wu ZH, He YY, Zhang KR, Ren L, Wang YR, Li YB, Gao J, Xiao L, Liu YH
Theranostics 2026;16(5):2466-2487
Theranostics 2026;16(5):2466-2487
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Tang Z, Ou Z, Wan H, Tao M, Li X, Huang Y, Tan Q, Peng Q, Dong L, Zhao J
International immunopharmacology 2026 May 15;177:116463
International immunopharmacology 2026 May 15;177:116463
Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles.
Gong Q, Zhao W, Wang T, Pan Y, Cui C, Qu Y, Zhou X
The Journal of biological chemistry 2026 Mar;302(3):111182
The Journal of biological chemistry 2026 Mar;302(3):111182
PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma.
Liu Y, Cheng Z, Zhang J, Zhang Y, Zhao T, Sun L, Wen G, Han T, Wang J
Autophagy 2026 Mar;22(3):468-483
Autophagy 2026 Mar;22(3):468-483
Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediated mitophagy and xenophagy.
Li J, Yang Y, Ge Y, Zhang X, Liu H, Chen Y, Yang Y, Wu Z
Autophagy 2026 Mar;22(3):445-467
Autophagy 2026 Mar;22(3):445-467
Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis.
Chen X, Li J, Liu Y, Li L, Deng X, Sheng Y, Zhu X, Jiang X, Li W, Cai X, Sun Q, Hu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e07509
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e07509
Numb attenuates LPS-induced neuroinflammation via autophagic regulation of Ifi204 in microglia.
Zhang S, Zang L, Li Y, Zhang Y, Chen X, Xin Y, He G, Zhou Z, Halalmeh I, Liang Y, Li W, Yang J, Geng J, Xiong X
Neurobiology of disease 2026 Jun 1;223:107386
Neurobiology of disease 2026 Jun 1;223:107386
Cathepsin B regulated via TFEB and lysosomal membrane permeabilization in adipose tissue macrophages aggravates obesity-related severe acute pancreatitis.
Ling X, Han C, Sheng L, Ding Z
International immunopharmacology 2026 Jul 1;180:116695
International immunopharmacology 2026 Jul 1;180:116695
CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7-Positive Vesicle Fusion with Target Membranes.
Tian Y, Li J, Kang J, Xu X, Wang B, Lou S, Li J, Yang Y, Zhang Y, Zheng Y, Weng J, Liang Y, Ma W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e04665
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e04665
Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization, and bleeding is a major defect in Alzheimer's disease.
Fu H, Li J, Zhang C, Gao G, Ge Q, Guan X, Cui D
Neural regeneration research 2026 Feb 1;21(2):790-799
Neural regeneration research 2026 Feb 1;21(2):790-799
Targeting the HDAC4-NHE6-endosomal pH axis restores amyloid-β clearance and cognitive function in Alzheimer's disease mice.
Huang N, Hong R, Cui X, Cao L, Shi L, Chen B, Su Y, Xu X, Hua C, Ying T
Journal of nanobiotechnology 2026 Apr 3;24(1)
Journal of nanobiotechnology 2026 Apr 3;24(1)
Stabilizing MARCH7 as a ferro-guardian against ferroptosis.
Huang W, Wang R, Yang X, Yang S, Yang X, He G, Dai S, Li C, Gao L, Zhang T, Zhang P, Chen R, Zheng K, Wu J, Min J, Ba Q, Wang F, Zhang Q
Cell 2026 Apr 27;
Cell 2026 Apr 27;
NDST3 suppression restores lysosomal acidification and ameliorates amyloid-β and MAPT/tau pathology in Alzheimer's disease.
Ge C, Wang K, Tang H, Ke Y, Wang H, Fu Q, Xiu Y, Guo Y, Jia YF, Long Z, He G, Tang Q
Translational neurodegeneration 2026 Apr 21;15(1)
Translational neurodegeneration 2026 Apr 21;15(1)
ANXA2-mediated Phagocytosis Generates AR(+) Macrophages to Confer Enzalutamide Resistance in Prostate Cancer.
Luo Y, Luo T, Li L, Sun Q, Li D, Huang S, Li Z, Lin W, Ou Y, Du T, Peng S, Xu K, Cheng B, Huang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 16;:e75290
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 16;:e75290
Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson's disease pathogenesis.
Cheng C, Yang H, Tian L, Ni Y, Jia C, Le W, Wang Q
Frontiers in aging neuroscience 2025;17:1612389
Frontiers in aging neuroscience 2025;17:1612389
Fenofibrate suppresses Mycoplasma bovis infection via autophagy-mediated cholesterol regulation in bovine mammary epithelial cells and murine mammary tissue.
Xu M, Wang T, Deng X, Liu Y, Zhu Z, Barkema HW, Cobo ER, Kastelic JP, Zhou X, Han B
Frontiers in cellular and infection microbiology 2025;15:1731492
Frontiers in cellular and infection microbiology 2025;15:1731492
The lysosome-associated SLAMF7 inhibits the development of ovarian cancer by promoting lysosomal damage.
Zou W, Fang X, Qian Z, Nie L
Molecular and cellular endocrinology 2025 Sep 1;606:112586
Molecular and cellular endocrinology 2025 Sep 1;606:112586
Enhanced autophagic clearance of amyloid-β via histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo.
Long Z, Ge C, Zhao Y, Liu Y, Zeng Q, Tang Q, Dong Z, He G
Neural regeneration research 2025 Sep 1;20(9):2633-2644
Neural regeneration research 2025 Sep 1;20(9):2633-2644
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
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Redox biology 2025 Oct;86:103793
Redox biology 2025 Oct;86:103793
Dimethyl malonate preserves brain and neurobehavioral phenotype following neonatal hypoxia-ischemia by inhibiting FTH1-mediated ferritinophagy.
Jin Y, Wang X, Xu X, Zhou X, Wang Q, Zhang L, Li L, Jin M, Ni H
Redox biology 2025 Oct;86:103792
Redox biology 2025 Oct;86:103792
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation.
Yang J, Zhang H, Wang Y, Luo Y, Zheng W, Liu Y, Jiang Q, Deng J, Liu Q, Zhang P, Huang H, Yu C, Xu Z, Chen Y
Neuroscience bulletin 2025 Oct;41(10):1805-1823
Neuroscience bulletin 2025 Oct;41(10):1805-1823
UBE2D2 promotes gastric cancer progression by inhibiting ferroptosis through autophagy-dependent stabilization of CST1.
Yang Y, Xu J, Zhao Q, Zhang R, Wang Y, Shang C, Pan S, Hu C, Luo C
International journal of biological macromolecules 2025 Oct;327(Pt 2):147333
International journal of biological macromolecules 2025 Oct;327(Pt 2):147333
SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.
Yaxian L, Xiaodong W, Futao M, Huizhen W, Chuansheng W, Mengdi M, Bo Y, Yida L, Xin X, Ziqing F, Mingdian L, Yuxian S, Yongxiang L
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188
Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness.
Huang H, Shi W, Yan H, Fan L, Lu J, Long Z, Li X, Li J, Wang J, Liu L, Qian J
Autophagy 2025 Oct;21(10):2148-2167
Autophagy 2025 Oct;21(10):2148-2167
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.
Zhu MY, Guo YJ, Zhu YQ, Wang HZ, Wang HD, Chen HY, Jiang YX, Li H, Hui H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313
Lysosomal homeostasis regulates myocardial ischemia-reperfusion injury through autophagy pathway.
Li Y, Liu Y, Wu H, Zhang S, Liu D, Huang X, Zhou G, Zhang D, Yang X, Zhou T, Xiong Y
Scientific reports 2025 Oct 22;15(1):36952
Scientific reports 2025 Oct 22;15(1):36952
Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal.
Wang Q, Zhang M, Jiang W, Li D, Qi B, Shi S, Shi S, Yi C
Journal of nanobiotechnology 2025 Oct 11;23(1):662
Journal of nanobiotechnology 2025 Oct 11;23(1):662
Role of neuroglia cell-derived microvesicles in cobalt chloride-induced mitochondrial autophagy in neurons.
Li H, Zheng F, Shao W, Yu G, Hu H, Guo Z, Wu S, Tang Y, Li H
Toxicology 2025 Nov;517:154214
Toxicology 2025 Nov;517:154214
RIOK2 kinase regulates the translocation of the FADD-RIPK1-Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis.
Ma M, Wang F, Cui P, Zhang Y, Ma H, He Y, Cheng Y, Huang J, Wang J, Wu X, Yang H, Zheng R, Ma H, Cai Q, Wang L, Ge B
Nature communications 2025 Nov 17;16(1):10060
Nature communications 2025 Nov 17;16(1):10060
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy.
Wang BN, Du AY, Chen XH, Huang T, Mamun AA, Li P, Du ST, Feng YZ, Jiang LY, Xu J, Wang Y, Wang SS, Kim K, Zhou KL, Wu YQ, Hu SW, Xiao J
Acta pharmacologica Sinica 2025 May;46(5):1205-1220
Acta pharmacologica Sinica 2025 May;46(5):1205-1220
Liensinine overcomes EGFR-TKI resistance in lung adenocarcinoma through DRP1-mediated autophagy.
Chen Y, Shu C, Yan Z, Zhang S, Zhang W, Zhao J, Wang A, Li J, Zeng Y, Zhu J, Huang JA, Liu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156593
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156593
PCSK9 promotes progression of anaplastic thyroid cancer through E-cadherin endocytosis.
Zhang Y, Su W, Ji X, Yang Z, Guan Q, Pang Y, Zhong L, Wang Y, Xiang J
Cell death & disease 2025 May 6;16(1):362
Cell death & disease 2025 May 6;16(1):362
Cadmium-induced disruption of exosomal secretion and cellular pathways in leydig cells.
Ali W, Behan AA, Ma Y, Chen Y, Zheng H, Liu Z, Zou H
Journal of molecular histology 2025 May 28;56(3):177
Journal of molecular histology 2025 May 28;56(3):177
Oral exposure to nanoplastics altered lipid profiles in mouse intestine.
Luo S, Zhao X, Wang Y, Jiang M, Cao Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115304
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115304
USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3.
Chen Y, Ye B, Xu D, Lin W, Fang Z, Qu X, Han X, Luo W, Chen C, Huang W, Zhou H, Wu G, Wang Y, Liang G
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1643-1658
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1643-1658
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex.
Zhao C, Zhang T, Xue ST, Zhang P, Wang F, Li Y, Liu Y, Zhao L, Wu J, Yan Y, Mao X, Chen Y, Yuan J, Li Z, Li K
Cell metabolism 2025 Mar 4;37(3):692-707.e9
Cell metabolism 2025 Mar 4;37(3):692-707.e9
ATP6AP1 promotes cell proliferation and tamoxifen resistance in luminal breast cancer by inducing autophagy.
Yan Z, Huang A, Ma D, Hong C, Zhang S, He L, Rao H, Luo S
Cell death & disease 2025 Mar 25;16(1):201
Cell death & disease 2025 Mar 25;16(1):201
MTHFD2 Enhances cMYC O-GlcNAcylation to Promote Sunitinib Resistance in Renal Cell Carcinoma.
Liu J, Huang G, Lin H, Yang R, Zhan W, Luo C, Wu Y, Chen L, Mao X, Chen J, Huang B
Cancer research 2025 Mar 14;85(6):1113-1129
Cancer research 2025 Mar 14;85(6):1113-1129
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Xu C, Yu C, Zhang J, Zhang Z, Zhang J, Meng Y, Wang M, Wen M, Chen J, Ning Y, Chen X, Gu J, Su W, Liu B
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV.
Davidson JW, Jain R, Kizzar T, Geoghegan G, Nesbitt DJ, Cavanagh A, Abe A, Nyame K, Hunger A, Chao X, James I, Walesewicz H, Baldwin DA, Wade G, Michorowska S, Verma R, Schueler K, Hinkovska-Galcheva V, Shishkova E, Ding WX, Coon JJ, Shayman JA, Abu-Remaileh M, Simcox JA
Cell metabolism 2025 Jun 3;37(6):1413-1425.e6
Cell metabolism 2025 Jun 3;37(6):1413-1425.e6
Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules.
Zhang D, Li J, Liang Y, Li T, Ji M, Liu X, Li W, Chen P, Zhang J, Yang Z, Wang L, Chen H
Journal of medicinal chemistry 2025 Jun 26;68(12):12641-12657
Journal of medicinal chemistry 2025 Jun 26;68(12):12641-12657
Palmitoylation enhances the stability of porcine epidemic diarrhea virus spike protein by antagonizing its degradation via chaperone-mediated autophagy to facilitate viral proliferation.
Qian Q, Zhao S-s, Yang L, Xing G, Chen Y, Liang C, Wang H, Li R, Qiao S, Wang A, Zhang G
Journal of virology 2025 Jun 17;99(6):e0034725
Journal of virology 2025 Jun 17;99(6):e0034725
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
Xiang W, Zhang T, Li B, Li S, Zhang B, Fang S, Chen L, Gong Y, Huang B, Feng D, Wu J, Yuan J, Wu Y, Yan X, Jin R, Zhang X, Fang X, Lian J, Chen L, Zhou S, Ni Z
Nature aging 2025 Jul;5(7):1295-1316
Nature aging 2025 Jul;5(7):1295-1316
Visualizing bulk autophagy in vivo by tagging endogenous LC3B.
Gao X, Xiong Y, Ma H, Zhou H, Liu W, Sun Q
Autophagy 2025 Jul;21(7):1591-1607
Autophagy 2025 Jul;21(7):1591-1607
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Tang Q, Tang K, Markby GR, Parys M, Phadwal K, MacRae VE, Corcoran BM
Autophagy 2025 Jul;21(7):1433-1455
Autophagy 2025 Jul;21(7):1433-1455
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy.
Ai S, Tao J, Wang Y, Zhou J, Liu W, Li X, Wang L, Hou J, Zhao L, Wang Z, Peng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156901
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156901
TBBPA-BDBPE induces ferroptosis in trophoblasts through chaperone-mediated autophagy of GPX4.
Mu Y, Wang K, Kang Y, Fang Z, Yu S, Zhou J, Li S, Zhang M
Ecotoxicology and environmental safety 2025 Jul 1;299:118425
Ecotoxicology and environmental safety 2025 Jul 1;299:118425
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Chen Y, Shen J, Yuan M, Li H, Li Y, Zheng S, Han B, Zhang C, Liu S, Sun Q, Wu J
Journal of advanced research 2025 Jan;67:331-348
Journal of advanced research 2025 Jan;67:331-348
S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism.
Yang M, Cui W, Lv X, Xiong G, Sun C, Xuan H, Ma W, Cui X, Cheng Y, Han L, Chu B
Nature communications 2025 Jan 8;16(1):509
Nature communications 2025 Jan 8;16(1):509
Polymeric Polylactic Acid-Glycolic Acid-Based Nanoparticles Deliver Nintedanib Across the Blood-Brain Barrier to Inhibit Glioblastoma Growth.
Dang Y, Zhao Z, Wang B, Du A, Li S, Yuan G, Pan Y
International journal of molecular sciences 2025 Jan 7;26(2)
International journal of molecular sciences 2025 Jan 7;26(2)
Dapagliflozin and Sirtuin-1 interaction and mechanism for ameliorating atrial fibrillation in a streptozotocin-induced rodent diabetic model.
Lee WC, Lin YW, Shih JY, Chen ZC, Wu NC, Chang WT, Liu PY
Biomolecules & biomedicine 2025 Jan 30;25(3):608-622
Biomolecules & biomedicine 2025 Jan 30;25(3):608-622
Targeting on the PI3K/mTOR: a potential treatment strategy for clear cell ovarian carcinoma.
Zheng K, Jin G, Cao R, Gao Y, Xu J, Chai R, Kang Y
Cancer chemotherapy and pharmacology 2025 Jan 10;95(1):21
Cancer chemotherapy and pharmacology 2025 Jan 10;95(1):21
Investigation of oral toxicity of WS(2) nanosheets to mouse intestine: Pathological injury, trace element balance, lipid profile changes, and autophagy.
Zha X, Luo S, Wei L, Li F, Li Y, Cao Y
Journal of applied toxicology : JAT 2025 Feb;45(2):311-321
Journal of applied toxicology : JAT 2025 Feb;45(2):311-321
Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.
Dan X, Croteau DL, Liu W, Chu X, Robbins PD, Bohr VA
bioRxiv : the preprint server for biology 2025 Feb 20;
bioRxiv : the preprint server for biology 2025 Feb 20;
Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15.
Davidson JW, Jain R, Kizzar T, Geoghegan G, Nesbitt DJ, Cavanagh A, Abe A, Nyame K, Hunger A, Chao X, James I, Von Bank H, Baldwin DA, Wade G, Michorowska S, Verma R, Scheuler K, Hinkovska-Galcheva V, Shishkova E, Ding WX, Coon JJ, Shayman JA, Abu-Remaileh M, Simcox JA
bioRxiv : the preprint server for biology 2025 Feb 19;
bioRxiv : the preprint server for biology 2025 Feb 19;
Rab7-regulated ferroptosis contributes to tubular epithelial cells injury by degradation of GPX4 via chaperone-mediated autophagy in AKI.
Liu L, Wei Q, Wang R, Sun H, He S, Tang L, Zhang S, Liu Y, Yu S
American journal of physiology. Cell physiology 2025 Feb 1;328(2):C699-C709
American journal of physiology. Cell physiology 2025 Feb 1;328(2):C699-C709
Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti-Inflammation in Diabetic Wounds.
Cui S, Meng S, Liu Y, Chen S, Hu W, Huang Q, Chu Z, Zhong W, Ma L, Li Z, Jiang Y, Liu X, Fu X, Zhang C
Exploration (Beijing, China) 2025 Dec;5(6):20240062
Exploration (Beijing, China) 2025 Dec;5(6):20240062
α-hederin decreases the glycolysis level in intestinal epithelial cells via SNX10-mediated DEPDC5 degradation.
Feng H, Wang J, Tao L, Li L, Fan M, Yu C, Sun D, Cheng H, Shen W
Journal of pharmaceutical analysis 2025 Dec;15(12):101301
Journal of pharmaceutical analysis 2025 Dec;15(12):101301
Impaired lipolysis and mitochondrial dysfunction in the epididymal tissues of high-fat diet-fed mice.
Wu C, Xu Z, Liu C, Lv Z
Molecular biology reports 2025 Dec 5;53(1):162
Molecular biology reports 2025 Dec 5;53(1):162
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice.
Li TT, Guo XF, Zhao YJ, Cheng YH, Xin DQ, Song Y, Liu DX, Wang Z
Acta pharmacologica Sinica 2025 Aug;46(8):2105-2119
Acta pharmacologica Sinica 2025 Aug;46(8):2105-2119
Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning.
Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S, Luo S, Zhang C, Peng G, Li J, Yu J, Ling Y, Fan Z, Mo W, Yang Y, Zhang J
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Aug;21(8):e70331
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Aug;21(8):e70331
Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease.
Wei YY, Chen TT, Zhang DW, Zhang Y, Li F, Ding YC, Wang MY, Zhang L, Chen KG, Fei GH
Autophagy 2025 Aug;21(8):1717-1743
Autophagy 2025 Aug;21(8):1717-1743
LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux.
Wu F, Li C, Song X, Xie L
Cellular signalling 2025 Aug;132:111834
Cellular signalling 2025 Aug;132:111834
NLRP12 decreases TRIM25-mediated HK2 degradation to promote glycolysis and H3K18la in gastric cancer.
Zhou L, Wang Z, Huang Y, Zhang X, Jiang H, Guo Z, Zhou G, Liu H
Cell death & disease 2025 Aug 13;16(1):615
Cell death & disease 2025 Aug 13;16(1):615
Mycoplasma ovipnuemoniae impairs the immune response of sheep and suppresses neutrophil function by inhibiting S100A9.
Yan C, Dong T, Shan Y, Zhao B, Yang H, Cai Y, Li S, Liu Q, Chu Y, Hao H, Cheng Z, Liu M, Zhang Y
Veterinary microbiology 2025 Apr;303:110446
Veterinary microbiology 2025 Apr;303:110446
Design, Synthesis, and Biological Evaluation of Naphthalimide-Polyamine Conjugate as a Potential Anti-Colorectal Cancer Agent.
Dai F, Cao Y, Zhu C, Li Y, Ma X, Wang S, Liu H, Xie X, Gao L, Wang Y, Wang C
Chemistry & biodiversity 2025 Apr;22(4):e202401873
Chemistry & biodiversity 2025 Apr;22(4):e202401873
SNX10 Is Involved in Ovarian Cancer Cell Metastasis by Repolarizing Tumor-Associated Macrophages Through mTOR1/Lysosomes Pathway.
Chai R, Zheng K, Xu T, Wang H, Cheng X, Lu C, Kang Y
Biomedicines 2025 Apr 23;13(5)
Biomedicines 2025 Apr 23;13(5)
St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.
Guo Y, Wang S, Liu Q, Dong Y, Liu Y
PloS one 2024;19(12):e0316268
PloS one 2024;19(12):e0316268
Qingre Huoxue decoction attenuates myocardial ischemia‒reperfusion injury by regulating the autophagy‒endoplasmic reticulum stress axis via FAM134B-mediated ER-phagy.
Li R, Zhang J, Ji S, Fang J, Ji X, Zeng Y, Liu N, Wu W, Liu S
Frontiers in pharmacology 2024;15:1447610
Frontiers in pharmacology 2024;15:1447610
Novel mechanistic study of HDAC6 regulation of rheumatoid arthritis via CMA: exploring potential therapeutic targets.
Lin D, Lai W, Zheng N, Luo H, Chen X, Que W, Zhang N
Frontiers in pharmacology 2024;15:1383663
Frontiers in pharmacology 2024;15:1383663
MK8722 initiates early-stage autophagy while inhibiting late-stage autophagy via FASN-dependent reprogramming of lipid metabolism.
Wang L, Zhu H, Shi Z, Chen B, Huang H, Lin G, Li J, Yu H, Xu S, Chen G, Ou R, Dai C
Theranostics 2024;14(1):75-95
Theranostics 2024;14(1):75-95
CTCF-activated FUCA1 functions as a tumor suppressor by promoting autophagy flux and serum α-L-fucosidase serves as a potential biomarker for prognosis in ccRCC.
Zhao S, Sun J, Chang Q, Pang S, Zhang N, Fan Y, Liu J
Cancer cell international 2024 Sep 28;24(1):327
Cancer cell international 2024 Sep 28;24(1):327
Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis.
Li S, Ma L, Li X, Jiang Y, Luo Z, Yin F, Zhang Y, Chen Y, Wan S, Zhou H, Kong L, Wang X
Journal of medicinal chemistry 2024 Sep 12;67(17):15353-15372
Journal of medicinal chemistry 2024 Sep 12;67(17):15353-15372
The novel lnc-HZ12 suppresses autophagy degradation of BBC3 by preventing its interactions with HSPA8 to induce trophoblast cell apoptosis.
Zhao J, Xu Z, Xie J, Liang T, Wang R, Chen W, Mi C, Tian P, Guo J, Zhang H
Autophagy 2024 Oct;20(10):2255-2274
Autophagy 2024 Oct;20(10):2255-2274
Contribution of impaired autophagy, mitochondrial dysfunction and abnormal lipolysis to epididymal aging in mice.
Liu C, Wu C, Zhang S, Lv Z
Experimental gerontology 2024 Oct 1;195:112528
Experimental gerontology 2024 Oct 1;195:112528
Alcohol promotes hepatocyte injury via ER stress sensor XBP1s mediated regulation of autophagy and lysosomal activity.
Cheng Y, Rao P, Li S, Yu W, Tang Y, Wang R, He W, Liu J
Toxicology and applied pharmacology 2024 Nov;492:117117
Toxicology and applied pharmacology 2024 Nov;492:117117
COPZ1 regulates ferroptosis through NCOA4-mediated ferritinophagy in lung adenocarcinoma.
Wu A, Yang H, Xiao T, Gu W, Li H, Chen P
Biochimica et biophysica acta. General subjects 2024 Nov;1868(11):130706
Biochimica et biophysica acta. General subjects 2024 Nov;1868(11):130706
Porcine reproductive and respiratory syndrome virus degrades TANK-binding kinase 1 via chaperon-mediated autophagy to suppress type I interferon production and facilitate viral proliferation.
Zhao SS, Qian Q, Wang Y, Qiao S, Li R
Veterinary research 2024 Nov 14;55(1):151
Veterinary research 2024 Nov 14;55(1):151
Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization.
Lu S, Jin H, Nong T, Li D, Long K, Chen Y, Li Y, Xing H, Pan T, He S, Jiang K, Zhong F
Free radical biology & medicine 2024 Nov 1;224:506-520
Free radical biology & medicine 2024 Nov 1;224:506-520
Normal transferrin glycosylation does not rule out severe ALG1 deficiency.
Bosnyak I, Sadek M, Ranatunga W, Kozicz T, Morava E
JIMD reports 2024 May;65(3):135-143
JIMD reports 2024 May;65(3):135-143
Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy.
Lin ZH, Xiang HQ, Yu YW, Xue YJ, Wu C, Lin C, Ji KT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23677
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23677
Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion.
Li K, Wang A, Diao Y, Fan S
International immunopharmacology 2024 May 30;133:112155
International immunopharmacology 2024 May 30;133:112155
TRIM65 promotes renal cell carcinoma through ubiquitination and degradation of BTG3.
Zhang Q, Li Y, Zhu Q, Xie T, Xiao Y, Zhang F, Li N, Deng K, Xin H, Huang X
Cell death & disease 2024 May 22;15(5):355
Cell death & disease 2024 May 22;15(5):355
Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway.
Liu N, Fan X, Shao Y, Chen S, Wang T, Yao T, Chen X
Journal of translational medicine 2024 May 14;22(1):457
Journal of translational medicine 2024 May 14;22(1):457
HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells.
Zhang C, Chen X, Liu R, Zhao G
Neurochemical research 2024 Mar;49(3):706-717
Neurochemical research 2024 Mar;49(3):706-717
ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis.
Zhang T, Zhu S, Huang GW
World journal of gastroenterology 2024 Mar 28;30(12):1764-1776
World journal of gastroenterology 2024 Mar 28;30(12):1764-1776
GLA Mutations Suppress Autophagy and Stimulate Lysosome Generation in Fabry Disease.
Li P, Xi Y, Zhang Y, Samad A, Lan W, Wu Y, Zhao J, Chen G, Wu C, Xiong Q
Cells 2024 Mar 1;13(5)
Cells 2024 Mar 1;13(5)
A pan-KRAS degrader for the treatment of KRAS-mutant cancers.
Yang J, Wang QL, Wang GN, Ye JC, Li ZQ, Wang JY, Liang ZH, Li SX, Sun C, Liao WT, Gao YJ, Wang J, Mao Y, Yu C, Feng GK, Zeng MS
Cell discovery 2024 Jun 28;10(1):70
Cell discovery 2024 Jun 28;10(1):70
Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis.
Wu JJ, Zhang SY, Mu L, Dong ZG, Zhang YJ
World journal of diabetes 2024 Jun 15;15(6):1317-1339
World journal of diabetes 2024 Jun 15;15(6):1317-1339
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes.
Chen Y, Yang F, Shi Y, Sheng J, Wang Y, Zhang L, Zhou J, Jin Y, Yan Y
Free radical biology & medicine 2024 Jul;219:163-179
Free radical biology & medicine 2024 Jul;219:163-179
Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.
Li X, Sun W, Huang M, Gong L, Zhang X, Zhong L, Calderon V, Bian Z, He Y, Suh WK, Li Y, Song T, Zou Y, Lian ZX, Gu H
Immunity 2024 Jul 9;57(7):1603-1617.e7
Immunity 2024 Jul 9;57(7):1603-1617.e7
Overexpression of SESN1 improves mitochondrial damage and mitophagy, a potential therapeutic strategy for cognitive dysfunction after anaesthesia.
Sun L, Hong X, Wang D, Li Y
The European journal of neuroscience 2024 Jan;59(2):208-219
The European journal of neuroscience 2024 Jan;59(2):208-219
TRPML1 contributes to antimony-induced nephrotoxicity by initiating ferroptosis via chaperone-mediated autophagy.
Liu L, Luo C, Zheng D, Wang X, Wang R, Ding W, Shen Z, Xue P, Yu S, Liu Y, Zhao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114378
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114378
Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation.
Chen T, Zhang Y, Zhang Y, Ning Z, Xu Q, Lin Y, Gong J, Li J, Chen Z, Meng Y, Li Y, Li X
Hepatology international 2024 Feb;18(1):273-288
Hepatology international 2024 Feb;18(1):273-288
A Novel Cargo Delivery System-AnCar-Exo(LaIMTS) Ameliorates Arthritis via Specifically Targeting Pro-Inflammatory Macrophages.
Li S, Wu YR, Peng XQ, Chen HG, Zhang TY, Chen H, Yang J, Xie YL, Qi HB, Xiang W, Huang B, Zhou SR, Hu Y, Tan QY, Du XL, Huang JL, Zhang RB, Li XH, Luo FT, Jin M, Su N, Luo XQ, Huang S, Yang P, Yan XJ, Lian JQ, Zhu Y, Xiong Y, Xiao GY, Liu YY, Shen C, Kuang L, Ni ZH, Chen L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2306143
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2306143
Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway.
Gu R, Bai L, Yan F, Zhang S, Zhang X, Deng R, Zeng X, Sun B, Hu X, Li Y, Bai J
Cell death discovery 2024 Feb 22;10(1):93
Cell death discovery 2024 Feb 22;10(1):93
Shaoyao-Gancao Decoction, a famous Chinese medicine formula, protects against APAP-induced liver injury by promoting autophagy/mitophagy.
Wu Y, Li W, Zhang J, Lin J, You L, Su J, Zheng C, Gao Y, Kong X, Sun X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156053
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156053
The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα.
Wang T, Luo R, Zhang J, Lan J, Lu Z, Zhai H, Li LF, Sun Y, Qiu HJ
Emerging microbes & infections 2024 Dec;13(1):2333381
Emerging microbes & infections 2024 Dec;13(1):2333381
Restoration of miR-299-3p promotes efferocytosis and ameliorates atherosclerosis via repressing CD47 in mice.
Zhu Y, Ren S, Huang H, Wu J, You X, Gao J, Ren Y, Wang R, Zhao W, Tan S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23857
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23857
Optogenetic manipulation of lysosomal physiology and autophagy-dependent clearance of amyloid beta.
Zeng W, Li C, Wu R, Yang X, Wang Q, Lin B, Wei Y, Li H, Shan G, Qu L, Cang C
PLoS biology 2024 Apr;22(4):e3002591
PLoS biology 2024 Apr;22(4):e3002591
Dysregulation of Autophagy Occurs During Congenital Cataract Development in βA3ΔG91 Mice.
Boateng AK, Joseph R, Srivastava OP
Investigative ophthalmology & visual science 2024 Apr 1;65(4):4
Investigative ophthalmology & visual science 2024 Apr 1;65(4):4
Identification and analysis of type 2 diabetes-mellitus-associated autophagy-related genes.
Cui K, Li Z
Frontiers in endocrinology 2023;14:1164112
Frontiers in endocrinology 2023;14:1164112
TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy.
Yu B, Jin L, Yao X, Zhang Y, Zhang G, Wang F, Su X, Fang Q, Xiao L, Yang Y, Jiang LH, Chen J, Yang W, Lin W, Han F
Theranostics 2023;13(13):4356-4375
Theranostics 2023;13(13):4356-4375
Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.
Nakamura H, Tanaka T, Zheng C, Afione SA, Warner BM, Noguchi M, Atsumi T, Chiorini JA
Arthritis & rheumatology (Hoboken, N.J.) 2023 Sep;75(9):1586-1598
Arthritis & rheumatology (Hoboken, N.J.) 2023 Sep;75(9):1586-1598
WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury.
Deng Z, Wang Y, Liu J, Zhang H, Zhou L, Zhao H, Han Y, Yan S, Dong Z, Wang Y, Dai Y, Deng F
Redox biology 2023 Sep;65:102826
Redox biology 2023 Sep;65:102826
Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis.
Feng R, Liu J, Yang Z, Yao T, Ye P, Li X, Zhang J, Jiang H
Molecular neurobiology 2023 Oct;60(10):6001-6017
Molecular neurobiology 2023 Oct;60(10):6001-6017
Porcine deltacoronavirus accessory protein NS6 harnesses VPS35-mediated retrograde trafficking to facilitate efficient viral infection.
Fang P, Zhang H, Cheng T, Ding T, Xia S, Xiao W, Li Z, Xiao S, Fang L
Journal of virology 2023 Oct 31;97(10):e0095723
Journal of virology 2023 Oct 31;97(10):e0095723
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress.
Wang J, Wen Y, Zhao W, Zhang Y, Lin F, Ouyang C, Wang H, Yao L, Ma H, Zhuo Y, Huang H, Shi X, Feng L, Lin D, Jiang B, Li Q
eLife 2023 Oct 30;12
eLife 2023 Oct 30;12
Mitophagy and mitochondrion-related expression profiles in response to physiological and pathological hypoxia in the corneal epithelium.
Wu MF, Peng X, Zhao JL, Zhang MC, Xie HT
Genomics 2023 Nov;115(6):110739
Genomics 2023 Nov;115(6):110739
RAB7A GTPase Is Involved in Mitophagosome Formation and Autophagosome-Lysosome Fusion in N2a Cells Treated with the Prion Protein Fragment 106-126.
Li Z, Lai M, Li J, Yang D, Zhao M, Wang D, Sun Z, Wen P, Gou F, Dai Y, Ji Y, Zhao D, Qiao J, Yang L
Molecular neurobiology 2023 Mar;60(3):1391-1407
Molecular neurobiology 2023 Mar;60(3):1391-1407
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857
Autophagy 2023 Mar;19(3):839-857
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition.
Chu Q, An J, Liu P, Song Y, Zhai X, Yang R, Niu J, Yang C, Li B
The Journal of experimental medicine 2023 Mar 6;220(3)
The Journal of experimental medicine 2023 Mar 6;220(3)
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
Pei X, Liu D, Li J, Li L, Ding X, Zhang W, Li Z, Xu G, Li C, Li D
The Science of the total environment 2023 Mar 20;865:161242
The Science of the total environment 2023 Mar 20;865:161242
Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation.
Shi Z, Li Z, Jin B, Ye W, Wang L, Zhang S, Zheng J, Lin Z, Chen B, Liu F, Zhang B, Ding X, Yang Z, Shan Y, Yu Z, Wang Y, Chen J, Chen Q, Roberts LR, Chen G
Clinical and translational medicine 2023 Jun;13(6):e1300
Clinical and translational medicine 2023 Jun;13(6):e1300
Autophagy and exosomes coordinately mediate quercetin's protective effects on alcoholic liver disease.
Chen H, Liu J, Peng S, Yang G, Cheng X, Chen L, Zhang H, Zhao Y, Yao P, Tang Y
The Journal of nutritional biochemistry 2023 Jun;116:109332
The Journal of nutritional biochemistry 2023 Jun;116:109332
The human discs large protein 1 interacts with and maintains connexin 43 at the plasma membrane in keratinocytes.
Scott H, Dong L, Stevenson A, MacDonald AI, Srinivasan S, Massimi P, Banks L, Martin PE, Johnstone SR, Graham SV
Journal of cell science 2023 Jun 1;136(11)
Journal of cell science 2023 Jun 1;136(11)
Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy.
Wang X, Xu F, Kou H, Zheng Y, Yang J, Xu Z, Fang Y, Sun W, Zhu S, Jiang Q, Wei X, Xu Y
Journal of extracellular vesicles 2023 Jul;12(7):e12342
Journal of extracellular vesicles 2023 Jul;12(7):e12342
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics.
Xu X, Feng Y, Han C, Yao Z, Liu Y, Luo C, Sheng J
Environmental toxicology 2023 Jan;38(1):205-215
Environmental toxicology 2023 Jan;38(1):205-215
Zhachong Shisanwei Pill resists ischemic stroke by lysosome pathway based on proteomics and bioinformatics.
Song Q, Bi L, Jiao J, Shang J, Li Q, Shabuerjiang L, Bai M, Liu X
Journal of ethnopharmacology 2023 Jan 30;301:115766
Journal of ethnopharmacology 2023 Jan 30;301:115766
Impaired autophagy flux by lncRNA NEAT1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment.
Zhang T, Yang K, Chen Y, Jiang Y, Zhou Z, Liu J, Du Y, Wang L, Han X, Wu X, Wang X
Journal of periodontal research 2023 Feb;58(1):70-82
Journal of periodontal research 2023 Feb;58(1):70-82
Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.
Zhang G, Jiang C, Yang Y, Wang Y, Zhou H, Dai S, Liu M, Yang Y, Yang L, Shen Q, Zhang T, Zhang X, Yang Y, Shen Y
Cell death and differentiation 2023 Feb;30(2):500-514
Cell death and differentiation 2023 Feb;30(2):500-514
Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes.
Du ZQ, Pang YQ, Zhang Y, Wang L, Zhang R, Li H, Yang CX
Poultry science 2023 Feb;102(2):102363
Poultry science 2023 Feb;102(2):102363
Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.
Liu Z, Fan M, Hou J, Pan S, Xu Y, Zhang H, Liu C, Hao X, Li X, Wang H
Cell death & disease 2023 Feb 20;14(2):144
Cell death & disease 2023 Feb 20;14(2):144
Corilagin attenuates intestinal ischemia/reperfusion injury in mice by inhibiting ferritinophagy-mediated ferroptosis through disrupting NCOA4-ferritin interaction.
Wang Y, Li B, Liu G, Han Q, Diao Y, Liu J
Life sciences 2023 Dec 1;334:122176
Life sciences 2023 Dec 1;334:122176
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
Li N, Chen L, Zhao X, Gu C, Chang Y, Feng S
Cell death discovery 2023 Aug 24;9(1):309
Cell death discovery 2023 Aug 24;9(1):309
HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis.
Han Z, Hu H, Yin M, Lin Y, Yan Y, Han P, Liu B, Jing B
Molecular medicine (Cambridge, Mass.) 2023 Aug 1;29(1):104
Molecular medicine (Cambridge, Mass.) 2023 Aug 1;29(1):104
Cadmium-induced impairment of spermatozoa development by reducing exosomal-MVBs secretion: a novel pathway.
Ali W, Bian Y, Ali H, Sun J, Zhu J, Ma Y, Liu Z, Zou H
Aging 2023 Apr 25;15(10):4096-4107
Aging 2023 Apr 25;15(10):4096-4107
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Li J, Bai J, Si X, Jia H, Wu Z
Chemico-biological interactions 2023 Apr 1;374:110386
Chemico-biological interactions 2023 Apr 1;374:110386
Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in Nonsmall-Cell Lung Cancer.
Chang M, Ding S, Dong X, Shang X, Li Y, Xie L, Song X, Song X
Journal of oncology 2022;2022:1533779
Journal of oncology 2022;2022:1533779
Prototheca bovis induces autophagy in bovine mammary epithelial cells via the HIF-1α and AMPKα/ULK1 pathway.
Zhao W, Xu M, Barkema HW, Xie X, Lin Y, Khan S, Kastelic JP, Wang D, Deng Z, Han B
Frontiers in immunology 2022;13:934819
Frontiers in immunology 2022;13:934819
YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis.
Zhang J, Zheng Y, Wang Y, Wang J, Sang A, Song X, Li X
Frontiers in immunology 2022;13:884362
Frontiers in immunology 2022;13:884362
RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux.
Jiang H, Zhang D, Aleksandrovich KD, Ye J, Wang L, Chen X, Gao M, Wang X, Yan T, Yang H, Lu E, Liu W, Zhang C, Wu J, Yao P, Sun Z, Rong X, Timofeevich SA, Mahmutovich SS, Zheng Z, Chen X, Zhao S
Frontiers in oncology 2022;12:887294
Frontiers in oncology 2022;12:887294
The effect of aerobic exercise on the lipophagy of adipose tissue in obese male mice.
Li R, Li G, Hai Y, Li T, Bian Y, Ma T
Chemistry and physics of lipids 2022 Sep;247:105225
Chemistry and physics of lipids 2022 Sep;247:105225
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
Zhou J, Zhang Y, Zeng L, Wang X, Mu H, Wang M, Pan H, Su P
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.
Chen Y, Zhang H, Li Y, Ji S, Jia P, Wang T
Journal of agricultural and food chemistry 2022 Oct 26;70(42):13661-13675
Journal of agricultural and food chemistry 2022 Oct 26;70(42):13661-13675
YAP1 protects against septic liver injury via ferroptosis resistance.
Wang J, Zhu Q, Li R, Zhang J, Ye X, Li X
Cell & bioscience 2022 Oct 1;12(1):163
Cell & bioscience 2022 Oct 1;12(1):163
Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy.
Wang J, Yang G, Zhang L, Zhang J, Wang J, Zou Y, Wang J
Virus research 2022 Nov;321:198905
Virus research 2022 Nov;321:198905
Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy.
Chen Y, Zhang H, Li Y, Ji S, Jia P, Wang T
Journal of animal science and biotechnology 2022 Nov 4;13(1):125
Journal of animal science and biotechnology 2022 Nov 4;13(1):125
Ppt1-deficiency dysregulates lysosomal Ca(++) homeostasis contributing to pathogenesis in a mouse model of CLN1 disease.
Mondal A, Appu AP, Sadhukhan T, Bagh MB, Previde RM, Sadhukhan S, Stojilkovic S, Liu A, Mukherjee AB
Journal of inherited metabolic disease 2022 May;45(3):635-656
Journal of inherited metabolic disease 2022 May;45(3):635-656
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6
Molecular cell 2022 May 19;82(10):1821-1835.e6
Progranulin Insufficiency Affects Lysosomal Homeostasis in Retinal Pigment Epithelium.
Takahashi K, Nakamura S, Shimazawa M, Hara H
In vivo (Athens, Greece) 2022 Mar-Apr;36(2):610-617
In vivo (Athens, Greece) 2022 Mar-Apr;36(2):610-617
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.
Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L
Redox biology 2022 Jun;52:102292
Redox biology 2022 Jun;52:102292
SUMO2-mediated SUMOylation of SH3GLB1 promotes ionizing radiation-induced hypertrophic cardiomyopathy through mitophagy activation.
Gao A, Zou J, Mao Z, Zhou H, Zeng G
European journal of pharmacology 2022 Jun 5;924:174980
European journal of pharmacology 2022 Jun 5;924:174980
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.
Lu J, Fu S, Dai J, Hu J, Li S, Ji H, Wang Z, Yu J, Bao J, Xu B, Guo J, Yang H
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
Journal of Zhejiang University. Science. B 2022 Jun 15;23(6):461-480
CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.
Tan J, Xu T, Gou Y, Wang H, Liang Z, Cao Y, Wang H, Yu Y, Jiao N, Zhang Z
Stem cell research & therapy 2022 Jul 15;13(1):294
Stem cell research & therapy 2022 Jul 15;13(1):294
PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer.
Salvi A, Young AN, Huntsman AC, Pergande MR, Korkmaz MA, Rathnayake RA, Mize BK, Kinghorn AD, Zhang X, Ratia K, Schirle M, Thomas JR, Brittain SM, Shelton C, Aldrich LN, Cologna SM, Fuchs JR, Burdette JE
Cell death & disease 2022 Jan 10;13(1):45
Cell death & disease 2022 Jan 10;13(1):45
Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.
Tanishita Y, Sekiya H, Inohara N, Tsuchiya K, Mitsuyama M, Núñez G, Hara H
Cell reports 2022 Feb 22;38(8):110414
Cell reports 2022 Feb 22;38(8):110414
Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction.
Luo L, Liang Y, Fu Y, Liang Z, Zheng J, Lan J, Shen F, Huang Z
Pharmaceuticals (Basel, Switzerland) 2022 Dec 3;15(12)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 3;15(12)
Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages.
Wen Y, Chen Z, Tian Y, Yang M, Dong Q, Yang Y, Ding H
Veterinary research 2022 Aug 4;53(1):62
Veterinary research 2022 Aug 4;53(1):62
GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis.
Yu S, Li Z, Zhang Q, Wang R, Zhao Z, Ding W, Wang F, Sun C, Tang J, Wang X, Zhang H, Huang R, Wu Q, Jiang J, Zhao X
Ecotoxicology and environmental safety 2022 Apr 1;234:113413
Ecotoxicology and environmental safety 2022 Apr 1;234:113413
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Jin C, Ou Q, Chen J, Wang T, Zhang J, Wang Z, Wang Y, Tian H, Xu JY, Gao F, Wang J, Li J, Lu L, Xu GT
Stem cell research & therapy 2022 Apr 1;13(1):136
Stem cell research & therapy 2022 Apr 1;13(1):136
PINK1 Alleviates Cognitive Impairments via Attenuating Pathological Tau Aggregation in a Mouse Model of Tauopathy.
Jiang XJ, Wu YQ, Ma R, Chang YM, Li LL, Zhu JH, Liu GP, Li G
Frontiers in cell and developmental biology 2021;9:736267
Frontiers in cell and developmental biology 2021;9:736267
Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta.
Zhao L, Liu D, Ma W, Gu H, Wei X, Luo W, Yuan Z
Frontiers in cell and developmental biology 2021;9:644346
Frontiers in cell and developmental biology 2021;9:644346
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.
Yu YW, Que JQ, Liu S, Huang KY, Qian L, Weng YB, Rong FN, Wang L, Zhou YY, Xue YJ, Ji KT
Frontiers in cardiovascular medicine 2021;8:768214
Frontiers in cardiovascular medicine 2021;8:768214
SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment.
Shang C, Liu Z, Zhu Y, Lu J, Ge C, Zhang C, Li N, Jin N, Li Y, Tian M, Li X
Frontiers in microbiology 2021;12:780768
Frontiers in microbiology 2021;12:780768
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Yu Y, Liu X, Zhao Z, Xu Z, Qiao Y, Zhou Y, Qiao H, Zhong J, Dai J, Suo G
Frontiers in pharmacology 2021;12:747223
Frontiers in pharmacology 2021;12:747223
Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH.
Zeng H, Chen H, Li M, Zhuang J, Peng Y, Zhou H, Xu C, Yu Q, Fu X, Cao S, Cai J, Yan F, Chen G
Journal of neuroinflammation 2021 Sep 16;18(1):210
Journal of neuroinflammation 2021 Sep 16;18(1):210
CLEC5A knockdown protects against cardiac dysfunction after myocardial infarction by suppressing macrophage polarization, NLRP3 inflammasome activation, and pyroptosis.
Wang X, Hu Y, Wang Y, Shen D, Tao G
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Oct;99(5):655-665
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Oct;99(5):655-665
Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.
Lu J, Xu S, Huo Y, Sun D, Hu Y, Wang J, Zhang X, Wang P, Li Z, Liang M, Wu Z, Liu P
Cell death and differentiation 2021 Oct;28(10):2871-2887
Cell death and differentiation 2021 Oct;28(10):2871-2887
Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR-p70S6K pathway.
Zuo SQ, Li C, Liu YL, Tan YH, Wan X, Xu T, Li Q, Wang L, Wu YL, Deng FM, Tang B
FEBS open bio 2021 Oct;11(10):2705-2714
FEBS open bio 2021 Oct;11(10):2705-2714
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Wang S, Xu X, Che D, Fan R, Gao M, Cao Y, Ge C, Feng Y, Li J, Xie S, Wang C, Dai F, Gao L, Wang Y
International journal of molecular sciences 2021 Oct 12;22(20)
International journal of molecular sciences 2021 Oct 12;22(20)
Fatty acid binding protein 3 deficiency limits atherosclerosis development via macrophage foam cell formation inhibition.
Tan L, Lu J, Liu L, Li L
Experimental cell research 2021 Oct 1;407(1):112768
Experimental cell research 2021 Oct 1;407(1):112768
Inhibition of Autophagy Suppresses SARS-CoV-2 Replication and Ameliorates Pneumonia in hACE2 Transgenic Mice and Xenografted Human Lung Tissues.
Shang C, Zhuang X, Zhang H, Li Y, Zhu Y, Lu J, Ge C, Cong J, Li T, Li N, Tian M, Jin N, Li X
Journal of virology 2021 Nov 23;95(24):e0153721
Journal of virology 2021 Nov 23;95(24):e0153721
Glucose-induced decrease of cystathionine β-synthase mediates renal injuries.
Yu Y, Xiao L, Ren Z, Zhu G, Wang W, Jia Y, Peng A, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21576
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21576
Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
Kang J, Kim JW, Heo H, Lee J, Park KY, Yoon JH, Chang J
Clinical and translational science 2021 Mar;14(2):606-616
Clinical and translational science 2021 Mar;14(2):606-616
Atmospheric particulate matter impedes autophagic flux by impairing lysosomal milieu and integrity in human umbilical vein endothelial cells (HUVECs).
Wang Y, Liu N, Huang X, Hu W, Ma Y, Liang Y, Xie W, Tang M
The Science of the total environment 2021 Mar 20;761:143290
The Science of the total environment 2021 Mar 20;761:143290
Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca(2+)/CaMKII signal pathway.
Chen TT, Zhou X, Xu YN, Li Y, Wu XY, Xiang Q, Fu LY, Hu XX, Tao L, Shen XC
Aging 2021 Mar 10;13(7):9542-9565
Aging 2021 Mar 10;13(7):9542-9565
Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy.
Chen L, Mei G, Jiang C, Cheng X, Li D, Zhao Y, Chen H, Wan C, Yao P, Gao C, Tang Y
Cell proliferation 2021 Jun;54(6):e13052
Cell proliferation 2021 Jun;54(6):e13052
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Zhu Q, Liu Z, Wang Y, Song E, Song Y
Journal of hazardous materials 2021 Jun 5;411:124958
Journal of hazardous materials 2021 Jun 5;411:124958
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI.
Chen C, Wang D, Yu Y, Zhao T, Min N, Wu Y, Kang L, Zhao Y, Du L, Zhang M, Gong J, Zhang Z, Zhang Y, Mi X, Yue S, Tan X
Cell death & disease 2021 Jan 11;12(1):65
Cell death & disease 2021 Jan 11;12(1):65
Mutation analysis of MFSD8 in an amyotrophic lateral sclerosis cohort from mainland China.
Huang L, Liu Z, Yuan Y, Shen L, Jiang H, Tang B, Wang J, Lei L
The European journal of neuroscience 2021 Feb;53(4):1197-1206
The European journal of neuroscience 2021 Feb;53(4):1197-1206
Classical swine fever virus infection suppresses claudin-1 expression to facilitate its replication in PK-15 cells.
Wang X, Yang Y, Yang X, Liu X, Wang X, Gao L, Yang C, Lan R, Bi J, Zhao Q, Yang G, Wang J, Lin Y, Liu J, Yin G
Microbial pathogenesis 2021 Aug;157:105012
Microbial pathogenesis 2021 Aug;157:105012
Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.
Xiao W, Yeerken D, Li J, Li Z, Jiang L, Li D, Fu M, Ma L, Song Y, Zhang W, Zhan Q
Signal transduction and targeted therapy 2021 Apr 16;6(1):152
Signal transduction and targeted therapy 2021 Apr 16;6(1):152
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.
Yang Y, Wang Q, Song D, Zen R, Zhang L, Wang Y, Yang H, Zhang D, Jia J, Zhang J, Wang J
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):197
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):197
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
Liu N, Yang Y, Chen J, Jia H, Zhang Y, Jiang D, Wu G, Wu Z
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress.
Shim MS, Nettesheim A, Hirt J, Liton PB
Autophagy 2020 Jul;16(7):1248-1261
Autophagy 2020 Jul;16(7):1248-1261
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Liu X, Bao X, Hu M, Chang H, Jiao M, Cheng J, Xie L, Huang Q, Li F, Li CY
Nature 2020 Dec;588(7839):693-698
Nature 2020 Dec;588(7839):693-698
Butyrate-mediated autophagy inhibition limits cytosolic Salmonella Infantis replication in the colon of pigs treated with a mixture of Lactobacillus and Bacillus.
Chu B, Zhu Y, Su J, Xia B, Zou Y, Nie J, Zhang W, Wang J
Veterinary research 2020 Aug 5;51(1):99
Veterinary research 2020 Aug 5;51(1):99
TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.
Zhang H, Tian X, Lu X, Xu D, Guo Y, Dong Z, Li Y, Ma Y, Chen C, Yang Y, Yang M, Yang Y, Liu F, Zhou R, He M, Xiao F, Wang X
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876
Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance.
Liu Y, Tang J, Liu D, Zhang L, He Y, Li J, Gao L, Tang D, Jin X, Kong D
Cell death & disease 2018 Apr 1;9(4):419
Cell death & disease 2018 Apr 1;9(4):419
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