Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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Comment
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- Product number
- ABIN497979 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- LAMP2 antibody was raised against a 17 amino acid peptide from near the carboxy of Human LAMP-2 (NP_054701).
- Description
- Immunoaffinity Chromatography
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- C-Term
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Autophagy as a cell death and tumor suppressor mechanism.
Tor-mediated induction of autophagy via an Apg1 protein kinase complex.
Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease).
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice.
The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c.
Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells.
Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.
Gozuacik D, Kimchi A
Oncogene 2004 Apr 12;23(16):2891-906
Oncogene 2004 Apr 12;23(16):2891-906
Tor-mediated induction of autophagy via an Apg1 protein kinase complex.
Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y
The Journal of cell biology 2000 Sep 18;150(6):1507-13
The Journal of cell biology 2000 Sep 18;150(6):1507-13
Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease).
Nishino I, Fu J, Tanji K, Yamada T, Shimojo S, Koori T, Mora M, Riggs JE, Oh SJ, Koga Y, Sue CM, Yamamoto A, Murakami N, Shanske S, Byrne E, Bonilla E, Nonaka I, DiMauro S, Hirano M
Nature 2000 Aug 24;406(6798):906-10
Nature 2000 Aug 24;406(6798):906-10
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice.
Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lüllmann-Rauch R, Janssen PM, Blanz J, von Figura K, Saftig P
Nature 2000 Aug 24;406(6798):902-6
Nature 2000 Aug 24;406(6798):902-6
The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c.
Gough NR, Hatem CL, Fambrough DM
DNA and cell biology 1995 Oct;14(10):863-7
DNA and cell biology 1995 Oct;14(10):863-7
Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells.
Kisen GO, Tessitore L, Costelli P, Gordon PB, Schwarze PE, Baccino FM, Seglen PO
Carcinogenesis 1993 Dec;14(12):2501-5
Carcinogenesis 1993 Dec;14(12):2501-5
Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.
Granger BL, Green SA, Gabel CA, Howe CL, Mellman I, Helenius A
The Journal of biological chemistry 1990 Jul 15;265(20):12036-43
The Journal of biological chemistry 1990 Jul 15;265(20):12036-43
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- AP20058PU-N CD107b/LAMP2 antibody staining of HepG2 cell lysate by Western Blotting at (A) 1 and (B) 2 ?g/ml.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- AP20058PU-N CD107b/LAMP2 antibody staining of HepG2 cells by Immunocytochemistry at 10 ?g/ml.