Antibody data
- Antibody Data
- Antigen structure
- References [28]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 25869-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- c-Met (Cytoplasmic) antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated c-Met (Cytoplasmic) antibody (Cat. #25869-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, canine, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.
Development and Validation of a Nomogram based on cell growth-related Biomarkers for Oral Squamous Cell Carcinoma.
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy.
CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c-Met signaling pathway.
miRNA in food simultaneously controls animal viral disease and human tumorigenesis.
Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors.
Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma.
Tivantinib Decreases Hepatocyte Growth Factor-Induced BCRP Expression in Hepatocellular Carcinoma HepG2 Cells.
Adipose-Derived Stem Cells Promote Proliferation and Invasion in Cervical Cancer by Targeting the HGF/c-MET Pathway.
The long noncoding RNA FTX promotes a malignant phenotype in bone marrow mesenchymal stem cells via the miR-186/c-Met axis.
Decorin promotes apoptosis and autophagy via suppressing c-Met in HTR-8 trophoblasts.
Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors.
Increased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met.
Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis.
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis.
Rosiglitazone Suppresses Calcium Oxalate Crystal Binding and Oxalate-Induced Oxidative Stress in Renal Epithelial Cells by Promoting PPAR-γ Activation and Subsequent Regulation of TGF-β1 and HGF Expression.
A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer.
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer.
Clinicopathologic Features and Prognostic Factors in Alpha-Fetoprotein-Producing Colorectal Cancer: Analysis of 78 Cases.
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer.
SOCS1 regulates hepatic regenerative response and provides prognostic makers for acute obstructive cholangitis.
Han Y, Ma R, Cao G, Liu H, He L, Tang L, Li H, Luo Q
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.
Hou P, Lin T, Meng S, Shi M, Chen F, Jiang T, Li Z, Li M, Chu S, Zheng J, Bai J
International journal of biological sciences 2021;17(8):1979-1994
International journal of biological sciences 2021;17(8):1979-1994
Development and Validation of a Nomogram based on cell growth-related Biomarkers for Oral Squamous Cell Carcinoma.
Shuai Y, Duan Y, Zhou M, Yue K, Liu D, Fang Y, Wang Y, Wu Y, Zhang Z, Wang X
Journal of Cancer 2021;12(17):5153-5163
Journal of Cancer 2021;12(17):5153-5163
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
Yuan Q, Liang Q, Sun Z, Yuan X, Hou W, Wang Y, Wang H, Yu M
Oncoimmunology 2021;10(1):1914954
Oncoimmunology 2021;10(1):1914954
Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy.
Li E, Huang X, Zhang G, Liang T
Journal of experimental & clinical cancer research : CR 2021 Sep 3;40(1):279
Journal of experimental & clinical cancer research : CR 2021 Sep 3;40(1):279
CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c-Met signaling pathway.
Zhao D, Yang Z, Chen C, Zhang Z, Yu Y, Li Z
FEBS open bio 2021 Nov;11(11):3115-3125
FEBS open bio 2021 Nov;11(11):3115-3125
miRNA in food simultaneously controls animal viral disease and human tumorigenesis.
Cui Y, Wan H, Zhang X
Molecular therapy. Nucleic acids 2021 Mar 5;23:995-1006
Molecular therapy. Nucleic acids 2021 Mar 5;23:995-1006
Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors.
Yuan X, Sun Z, Yuan Q, Hou W, Liang Q, Wang Y, Mo W, Wang H, Yu M
Investigational new drugs 2021 Feb;39(1):34-51
Investigational new drugs 2021 Feb;39(1):34-51
Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Dong X, Luo Y, Lu S, Ma H, Zhang W, Zhu Y, Sun G, Sun X
Clinical and translational medicine 2021 Feb;11(2):e296
Clinical and translational medicine 2021 Feb;11(2):e296
Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma.
Meng Y, Qian X, Zhao L, Li N, Wu S, Chen B, Sun T, Wang X
Cancer cell international 2021 Apr 15;21(1):216
Cancer cell international 2021 Apr 15;21(1):216
Tivantinib Decreases Hepatocyte Growth Factor-Induced BCRP Expression in Hepatocellular Carcinoma HepG2 Cells.
Kobayashi K, Higai K, Mukozu T, Matsui D, Amanuma M, Yoshimine N, Ogino Y, Matsui T, Wakui N, Shinohara M, Momiyama K, Daido Y, Nagai H, Igarashi Y
Biological & pharmaceutical bulletin 2020;43(9):1421-1425
Biological & pharmaceutical bulletin 2020;43(9):1421-1425
Adipose-Derived Stem Cells Promote Proliferation and Invasion in Cervical Cancer by Targeting the HGF/c-MET Pathway.
Zhai Y, Wu W, Xi X, Yu R
Cancer management and research 2020;12:11823-11832
Cancer management and research 2020;12:11823-11832
The long noncoding RNA FTX promotes a malignant phenotype in bone marrow mesenchymal stem cells via the miR-186/c-Met axis.
Liu L, Li X, Shi Y, Chen H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110666
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110666
Decorin promotes apoptosis and autophagy via suppressing c-Met in HTR-8 trophoblasts.
Wang Y, Zhang H, Zhang Y, Li X, Hu X, Wang X
Reproduction (Cambridge, England) 2020 May;159(6):669-677
Reproduction (Cambridge, England) 2020 May;159(6):669-677
Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors.
Xing M, Fu R, Liu Y, Wang P, Ma P, Zhu C, Fan D
Food & function 2020 May 1;11(5):4123-4137
Food & function 2020 May 1;11(5):4123-4137
Increased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met.
Chen JJ, Sun X, Mao QQ, Jiang XY, Zhao XG, Xu WJ, Zhong L
The Kaohsiung journal of medical sciences 2020 Mar;36(3):196-205
The Kaohsiung journal of medical sciences 2020 Mar;36(3):196-205
Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis.
Dong X, Kong F, Liu C, Dai S, Zhang Y, Xiao F, Zhang H, Wu CT, Wang H
Stem cell research & therapy 2020 Jun 10;11(1):229
Stem cell research & therapy 2020 Jun 10;11(1):229
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Chen Y, Tang J, Lu T, Liu F
Thoracic cancer 2020 Jul;11(7):1848-1860
Thoracic cancer 2020 Jul;11(7):1848-1860
CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
Ying Y, Li J, Xie H, Yan H, Jin K, He L, Ma X, Wu J, Xu X, Fang J, Wang X, Zheng X, Liu B, Xie L
Cell proliferation 2020 Feb;53(2):e12751
Cell proliferation 2020 Feb;53(2):e12751
SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis.
Liu R, Shuai Y, Luo J, Zhang Z
Frontiers in oncology 2019;9:1035
Frontiers in oncology 2019;9:1035
Rosiglitazone Suppresses Calcium Oxalate Crystal Binding and Oxalate-Induced Oxidative Stress in Renal Epithelial Cells by Promoting PPAR-γ Activation and Subsequent Regulation of TGF-β1 and HGF Expression.
Liu YD, Yu SL, Wang R, Liu JN, Jin YS, Li YF, An RH
Oxidative medicine and cellular longevity 2019;2019:4826525
Oxidative medicine and cellular longevity 2019;2019:4826525
A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer.
Hou W, Yuan Q, Yuan X, Wang Y, Mo W, Wang H, Yu M
Investigational new drugs 2019 Oct;37(5):876-889
Investigational new drugs 2019 Oct;37(5):876-889
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Huang X, Gan G, Wang X, Xu T, Xie W
Autophagy 2019 Jul;15(7):1258-1279
Autophagy 2019 Jul;15(7):1258-1279
Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer.
Li J, Ying Y, Xie H, Jin K, Yan H, Wang S, Xu M, Xu X, Wang X, Yang K, Zheng X, Xie L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1374-1388
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1374-1388
Clinicopathologic Features and Prognostic Factors in Alpha-Fetoprotein-Producing Colorectal Cancer: Analysis of 78 Cases.
Feng Y, Li Y, Dai W, Mo S, Li Q, Cai S
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(5):2052-2064
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(5):2052-2064
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Yuan H, Zhou W, Yang Y, Xue L, Liu L, Song Y
Experimental cell research 2018 Jun 1;367(1):47-55
Experimental cell research 2018 Jun 1;367(1):47-55
Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer.
Cui Y, Yang X, Zhang X
Molecular therapy. Nucleic acids 2017 Dec 15;9:387-398
Molecular therapy. Nucleic acids 2017 Dec 15;9:387-398
SOCS1 regulates hepatic regenerative response and provides prognostic makers for acute obstructive cholangitis.
Yu J, Zhang W, Qian H, Tang H, Lin W, Lu B
Scientific reports 2017 Aug 25;7(1):9482
Scientific reports 2017 Aug 25;7(1):9482
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 25869-1-AP( MET Antibody) at dilution of 1:300
- Validation comment
- WB
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-MET (IP:25869-1-AP, 5ug; Detection:25869-1-AP 1:300) with HeLa cells lysate 1600ug.
- Validation comment
- IP
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 25869-1-AP( MET Antibody) at dilution of 1:50 (under 10x lens)
- Validation comment
- IHC
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 25869-1-AP( MET Antibody) at dilution of 1:50 (under 40x lens)
- Validation comment
- IHC