Antibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
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- Product number
- 25869-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- c-Met (Cytoplasmic) antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated c-Met (Cytoplasmic) antibody (Cat. #25869-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, canine, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment.
METTL3 stabilizes FASN mRNA by mediating m(6)A modification to promote malignant progression of diffuse large B-cell lymphoma.
HSPA5 promotes YAP/TAZ stability independently of the Hippo pathway and induces proneural-to-mesenchymal transition in glioblastoma.
Aptamer-functionalized nanoparticles for CRISPR-Cas9 delivery to circulating malignant cells for therapeutic efficacy evaluation.
A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer.
Gut microbial metabolite, sphingosine-1-phosphate (S1P), drives mesangial cell phenotypic transformation and accelerates progression of IgA nephropathy via CCL2-MET-FAK pathway.
Identification of Novel Gene Signature Predicting Lymph Node Metastasis in Papillary Thyroid Cancer via Bioinformatics Analysis and in vitro Validation.
HGF/c-MET axis contributes to CLL cell survival by regulating multiple mechanisms making it a potential therapeutic target for CLL treatment.
Naringenin: A potential therapeutic agent for modulating angiogenesis and immune response in hepatocellular carcinoma.
Aurora kinase A drives non-canonical YAP1/TAZ crosstalk to sustain primary resistance to anti-EGFR therapies in colorectal cancer.
SNX17 knockdown improves post-ischemic angiogenesis via blocking lysosomal dependent VEGFR degradation.
Study on the in vitro and in vivo killing effects of PD-1 antibody-secreting c-Met-targeted CAR-T cells on esophageal cancer cell line ECA109.
EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.
Neurogenic inducers inhibit the proliferation of pancreatic cancer by promoting tumor cell transdifferentiation.
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol-Triggered MET Activation.
MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation.
TC2N promotes the proliferation and invasion of head and neck cancer cells with the p53-R175H.
A Simple Proton-Driven Allosteric Aptamer Nanorobot for Receptor Tyrosine Kinase Degradation and Behavior Modulation in Cancer Cells.
hnRNPU-mediated pathogenic alternative splicing drives gastric cancer progression.
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
The FBXW7-RPAP2 Axis Controls the Growth of Hepatocellular Carcinoma Cells and Determines the Fate of Liver Cell Differentiation.
Deoxycholic acid aggravates necrotizing enterocolitis through downregulation of mesenchymal-epithelial transition factor expression.
Construction of disulfidptosis-based immune response prediction model with artificial intelligence and validation of the pivotal grouping oncogene c-MET in regulating T cell exhaustion.
LIFR regulates cholesterol-driven bidirectional hepatocyte-neutrophil cross-talk to promote liver regeneration.
Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells.
Parathyroid hormone-related protein as a potential prostate cancer biomarker: Promoting prostate cancer progression through upregulation of c-Met expression.
Hypomethylation-enhanced CRTC2 expression drives malignant phenotypes and primary resistance to immunotherapy in hepatocellular carcinoma.
Neutrophil migration participates in the side effect of recombinant human tissue plasminogen activator.
MET exon 14 skipping mutation drives cancer progression and recurrence via activation of SMAD2 signalling.
Chimeric antigen receptor macrophages targeting c-MET(CAR-M-c-MET) inhibit pancreatic cancer progression and improve cytotoxic chemotherapeutic efficacy.
Mesothelin promotes brain metastasis of non-small cell lung cancer by activating MET.
IGF2BP2 promotes ovarian cancer growth and metastasis by upregulating CKAP2L protein expression in an m(6) A-dependent manner.
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
RFC2 promotes aerobic glycolysis and progression of colorectal cancer.
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
Clinicopathological features and immunophenotype of Silva pattern system in endocervical adenocarcinoma.
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling.
Identification and validation of autophagy-related gene expression for predicting prognosis in patients with idiopathic pulmonary fibrosis.
Time-extended exposure of gastric epithelial cells to secretome of Helicobacter pylori-activated fibroblasts induces reprogramming of gastric epithelium towards pre-cancerogenic and pro-invasive phenotype.
A four oxidative stress gene prognostic model and integrated immunity-analysis in pancreatic adenocarcinoma.
Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.
ORP5 promotes tumor metastasis via stabilizing c-Met in renal cell carcinoma.
Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.
Development and Validation of a Nomogram based on cell growth-related Biomarkers for Oral Squamous Cell Carcinoma.
Hepatocyte Growth Factor Overexpression Slows the Progression of 4NQO-Induced Oral Tumorigenesis.
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy.
CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c-Met signaling pathway.
Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer.
miRNA in food simultaneously controls animal viral disease and human tumorigenesis.
Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors.
Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma.
Tivantinib Decreases Hepatocyte Growth Factor-Induced BCRP Expression in Hepatocellular Carcinoma HepG2 Cells.
Adipose-Derived Stem Cells Promote Proliferation and Invasion in Cervical Cancer by Targeting the HGF/c-MET Pathway.
The long noncoding RNA FTX promotes a malignant phenotype in bone marrow mesenchymal stem cells via the miR-186/c-Met axis.
Decorin promotes apoptosis and autophagy via suppressing c-Met in HTR-8 trophoblasts.
Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors.
Increased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met.
Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis.
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis.
Rosiglitazone Suppresses Calcium Oxalate Crystal Binding and Oxalate-Induced Oxidative Stress in Renal Epithelial Cells by Promoting PPAR-γ Activation and Subsequent Regulation of TGF-β1 and HGF Expression.
A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer.
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer.
Clinicopathologic Features and Prognostic Factors in Alpha-Fetoprotein-Producing Colorectal Cancer: Analysis of 78 Cases.
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer.
SOCS1 regulates hepatic regenerative response and provides prognostic makers for acute obstructive cholangitis.
Fu D, Zhang M, Cai M, Wang M, Huang Z, Lin Z, Liu Y, Qian W, Chen G, Liang Y, Wei D, Xie J, Yan P, Qu Y, Wei Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(26):e16557
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(26):e16557
METTL3 stabilizes FASN mRNA by mediating m(6)A modification to promote malignant progression of diffuse large B-cell lymphoma.
Song X, Zhong Y, Yu N, Zou W, Li W, Lv Q, Luo Q, Zhong X
Cell & bioscience 2026 Mar 18;16(1)
Cell & bioscience 2026 Mar 18;16(1)
HSPA5 promotes YAP/TAZ stability independently of the Hippo pathway and induces proneural-to-mesenchymal transition in glioblastoma.
Gui S, Yu W, Song Z, Peng L, Luo H, Huang K, Xiao J, Xie J, Cai S, Yuan S, Tao Z, Cheng Z
Cell death & disease 2026 Feb 7;17(1):208
Cell death & disease 2026 Feb 7;17(1):208
Aptamer-functionalized nanoparticles for CRISPR-Cas9 delivery to circulating malignant cells for therapeutic efficacy evaluation.
Liao XR, Han D, Qi LJ, Huang QY, Gao QY, He XY, Guo T, Lei JJ, Cheng SX
Journal of controlled release : official journal of the Controlled Release Society 2026 Feb 10;390:114542
Journal of controlled release : official journal of the Controlled Release Society 2026 Feb 10;390:114542
A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer.
Ning W, Liu H, Zeng H, Qin X, Xu L, Yang S, Wang Y, Chen F, Yuan N, Chen X, Xu T, Wu K, Wang P, Liu C, Chen Y, Xia N, Liu X, Luo W
Cell reports. Medicine 2026 Apr 21;7(4):102688
Cell reports. Medicine 2026 Apr 21;7(4):102688
Gut microbial metabolite, sphingosine-1-phosphate (S1P), drives mesangial cell phenotypic transformation and accelerates progression of IgA nephropathy via CCL2-MET-FAK pathway.
Tang YY, Zhang DL, Huang LS, Hu P, Liu P, Wu JJ, Xie T, Sun WQ, Xu XD, Jin MP, He HD
Current research in microbial sciences 2025;9:100494
Current research in microbial sciences 2025;9:100494
Identification of Novel Gene Signature Predicting Lymph Node Metastasis in Papillary Thyroid Cancer via Bioinformatics Analysis and in vitro Validation.
Li H, Sun D, Jin K, Wang X
International journal of general medicine 2025;18:1463-1479
International journal of general medicine 2025;18:1463-1479
HGF/c-MET axis contributes to CLL cell survival by regulating multiple mechanisms making it a potential therapeutic target for CLL treatment.
Liang S, Shao X, Meng X, Cui Y, Sun C, Sun J, Zhang B, Shen G, Qin L, Yang H, Chen Y
Frontiers in pharmacology 2025;16:1612916
Frontiers in pharmacology 2025;16:1612916
Naringenin: A potential therapeutic agent for modulating angiogenesis and immune response in hepatocellular carcinoma.
Wu W, Qiu X, Ye X, Zhang Z, Xu S, Yao X, Du Y, Wu G, Zhang R, Zhu J
Journal of pharmaceutical analysis 2025 Sep;15(9):101254
Journal of pharmaceutical analysis 2025 Sep;15(9):101254
Aurora kinase A drives non-canonical YAP1/TAZ crosstalk to sustain primary resistance to anti-EGFR therapies in colorectal cancer.
Rio-Vilariño A, Garcia-Bautista A, Cenigaonandia-Campillo A, Mateos-Gomez PA, Garcia-Garcia L, Schlaepfer MI, Garcia-Hernandez L, Puerto-Nevado LD, Aguilera O, Baños N, Minguez P, Castellano VM, Garcia-Foncillas J, Cebrian A
Molecular therapy. Oncology 2025 Sep 18;33(3):201032
Molecular therapy. Oncology 2025 Sep 18;33(3):201032
SNX17 knockdown improves post-ischemic angiogenesis via blocking lysosomal dependent VEGFR degradation.
Tang Y, Tang S, Chen Y, Zhang J, Yu X, Mao P, Wang W, Yu J, Wang F, Zeng C
Life sciences 2025 Sep 15;377:123739
Life sciences 2025 Sep 15;377:123739
Study on the in vitro and in vivo killing effects of PD-1 antibody-secreting c-Met-targeted CAR-T cells on esophageal cancer cell line ECA109.
Peng S, Li Y, Zhang Y, Min J, An R, Du N, Li H, Zhen X, Chu F, Li Z
Discover oncology 2025 Oct 21;16(1):1933
Discover oncology 2025 Oct 21;16(1):1933
EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy.
Wang D, Liu Y, Chen Y, Dai C, Hu W, Han J, Li Z, Yin F, Zhang Y, Shi C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e10197
Neurogenic inducers inhibit the proliferation of pancreatic cancer by promoting tumor cell transdifferentiation.
Guo D, Shi S, Ye L, Yang M, Peng W, Yang J, Xu J, Fei Q, Li H, Jin K, Hu X, Wu W
Journal of experimental & clinical cancer research : CR 2025 Nov 12;44(1):304
Journal of experimental & clinical cancer research : CR 2025 Nov 12;44(1):304
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
Luo S, Wu F, Jin Y, Liu D
Journal of cellular and molecular medicine 2025 May;29(9):e70601
Journal of cellular and molecular medicine 2025 May;29(9):e70601
RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol-Triggered MET Activation.
Xu Y, Chen Y, Zhang J, Wang J, Yang S, Zhao H, Wu L, Lei J, Zhou Y, Peng J, Jiang L, Chen Q, Xin R, Zhou J, Li Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2411888
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2411888
MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation.
Wang T, Rao D, Fu C, Sun Z, Luo Y, Lu J, Jin J, Li H, Fan F, Liang H, Huang W, Xia L
Clinical and molecular hepatology 2025 Jul;31(3):1032-1057
Clinical and molecular hepatology 2025 Jul;31(3):1032-1057
TC2N promotes the proliferation and invasion of head and neck cancer cells with the p53-R175H.
Zhang Q, Zhou X, Hao X, Sun Q, Zhang G, Xu S
Translational cancer research 2025 Jul 30;14(7):3905-3919
Translational cancer research 2025 Jul 30;14(7):3905-3919
A Simple Proton-Driven Allosteric Aptamer Nanorobot for Receptor Tyrosine Kinase Degradation and Behavior Modulation in Cancer Cells.
Qi L, Wu Y, Zhang B, Zhou Y, He L, Zhang M, Wang K, Chen M, He X
ACS applied materials & interfaces 2025 Jul 23;17(29):41781-41791
ACS applied materials & interfaces 2025 Jul 23;17(29):41781-41791
hnRNPU-mediated pathogenic alternative splicing drives gastric cancer progression.
Jin G, Song Y, Fang S, Yan M, Yang Z, Shao Y, Zhao K, Liu M, Wang Z, Guo Z, Dong Z
Journal of experimental & clinical cancer research : CR 2025 Jan 7;44(1):8
Journal of experimental & clinical cancer research : CR 2025 Jan 7;44(1):8
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Ma YN, Jiang XM, Hu XQ, Wang L, Gao JJ, Liu H, Qi FH, Song PP, Tang W
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
The FBXW7-RPAP2 Axis Controls the Growth of Hepatocellular Carcinoma Cells and Determines the Fate of Liver Cell Differentiation.
Cui D, Shao S, Qu R, Chen X, Jiang S, Wang L, Gong L, Li T, Zhai D, Song W, Song P, Sun Y, Liang T, Xiong X, Zhao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2404718
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2404718
Deoxycholic acid aggravates necrotizing enterocolitis through downregulation of mesenchymal-epithelial transition factor expression.
Li H, Lai J, Xiao D, Huang D, Zhang Y, Gu X, Li F, Hao H
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2024;57:e14046
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2024;57:e14046
Construction of disulfidptosis-based immune response prediction model with artificial intelligence and validation of the pivotal grouping oncogene c-MET in regulating T cell exhaustion.
Li P, Wang S, Wan H, Huang Y, Yin K, Sun K, Jin H, Wang Z
Frontiers in immunology 2024;15:1258475
Frontiers in immunology 2024;15:1258475
LIFR regulates cholesterol-driven bidirectional hepatocyte-neutrophil cross-talk to promote liver regeneration.
Deng Y, Zhao Z, Sheldon M, Zhao Y, Teng H, Martinez C, Zhang J, Lin C, Sun Y, Yao F, Curran MA, Zhu H, Ma L
Nature metabolism 2024 Sep;6(9):1756-1774
Nature metabolism 2024 Sep;6(9):1756-1774
Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells.
Rio-Vilariño A, Cenigaonandia-Campillo A, García-Bautista A, Mateos-Gómez PA, Schlaepfer MI, Del Puerto-Nevado L, Aguilera O, García-García L, Galeano C, de Miguel I, Serrano-López J, Baños N, Fernández-Aceñero MJ, Lacal JC, Medico E, García-Foncillas J, Cebrián A
British journal of cancer 2024 May;130(8):1402-1413
British journal of cancer 2024 May;130(8):1402-1413
Parathyroid hormone-related protein as a potential prostate cancer biomarker: Promoting prostate cancer progression through upregulation of c-Met expression.
Zhao Y, Fu ZY, Feng HY, Peng YH, Yin ZX, Cao JY, Pei CS
Biomolecules & biomedicine 2024 Mar 11;24(2):374-386
Biomolecules & biomedicine 2024 Mar 11;24(2):374-386
Hypomethylation-enhanced CRTC2 expression drives malignant phenotypes and primary resistance to immunotherapy in hepatocellular carcinoma.
Zhang R, Dai J, Yao F, Zhou S, Huang W, Xu J, Yu K, Chen Y, Fan B, Zhang L, Xu J, Li Q
iScience 2024 Jun 21;27(6):109821
iScience 2024 Jun 21;27(6):109821
Neutrophil migration participates in the side effect of recombinant human tissue plasminogen activator.
Huang Y, Han Z, Shen T, Zheng Y, Yang Z, Fan J, Wang R, Yan F, Tao Z, Luo Y, Liu P
CNS neuroscience & therapeutics 2024 Jul;30(7):e14825
CNS neuroscience & therapeutics 2024 Jul;30(7):e14825
MET exon 14 skipping mutation drives cancer progression and recurrence via activation of SMAD2 signalling.
Liang Q, Hu Y, Yuan Q, Yu M, Wang H, Zhao B
British journal of cancer 2024 Feb;130(3):380-393
British journal of cancer 2024 Feb;130(3):380-393
Chimeric antigen receptor macrophages targeting c-MET(CAR-M-c-MET) inhibit pancreatic cancer progression and improve cytotoxic chemotherapeutic efficacy.
Zheng H, Yang X, Huang N, Yuan S, Li J, Liu X, Jiang Q, Wu S, Ju Y, Kleeff J, Yin X, Liao Q, Liu Q, Zhao Y
Molecular cancer 2024 Dec 6;23(1):270
Molecular cancer 2024 Dec 6;23(1):270
Mesothelin promotes brain metastasis of non-small cell lung cancer by activating MET.
Xia S, Duan W, Xu M, Li M, Tang M, Wei S, Lin M, Li E, Liu W, Wang Q
Journal of experimental & clinical cancer research : CR 2024 Apr 3;43(1):103
Journal of experimental & clinical cancer research : CR 2024 Apr 3;43(1):103
IGF2BP2 promotes ovarian cancer growth and metastasis by upregulating CKAP2L protein expression in an m(6) A-dependent manner.
Shi Y, Xiong X, Sun Y, Geng Z, Chen X, Cui X, Lv J, Ge L, Jia X, Xu J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23183
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23183
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Zhang M, Zhu LZ, Yang CJ, Yan JX, Wang ZP, Bai YP, Peng LZ, Luo HB, Zhang ZJ, Li L, Xu CR, Liu YQ
Bioorganic chemistry 2023 Oct;139:106652
Bioorganic chemistry 2023 Oct;139:106652
RFC2 promotes aerobic glycolysis and progression of colorectal cancer.
Lou F, Zhang M
BMC gastroenterology 2023 Oct 11;23(1):353
BMC gastroenterology 2023 Oct 11;23(1):353
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
Wu JC, Wang XJ, Zhu JH, Huang XY, Liu M, Qiao Z, Zhang Y, Sun Y, Wang ZY, Zhan P, Zhang T, Hu HL, Liu H, Tang W, Yi F
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
Clinicopathological features and immunophenotype of Silva pattern system in endocervical adenocarcinoma.
Zeng C, Wu JK, Lu X
International journal of experimental pathology 2023 Jun;104(3):140-150
International journal of experimental pathology 2023 Jun;104(3):140-150
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling.
Xu X, Deng L, Tang Y, Li J, Zhong T, Hao X, Fan Y, Mu S
International journal of molecular sciences 2023 Apr 30;24(9)
International journal of molecular sciences 2023 Apr 30;24(9)
Identification and validation of autophagy-related gene expression for predicting prognosis in patients with idiopathic pulmonary fibrosis.
Huang G, Xu X, Ju C, Zhong N, He J, Tang XX
Frontiers in immunology 2022;13:997138
Frontiers in immunology 2022;13:997138
Time-extended exposure of gastric epithelial cells to secretome of Helicobacter pylori-activated fibroblasts induces reprogramming of gastric epithelium towards pre-cancerogenic and pro-invasive phenotype.
Krzysiek-Maczka G, Targosz A, Wrobel T, Paw M, Szczyrk U, Opila J, Strzalka M, Wierdak M, Major P, Brzozowski T, Czyz J, Ptak-Belowska A
American journal of cancer research 2022;12(3):1337-1371
American journal of cancer research 2022;12(3):1337-1371
A four oxidative stress gene prognostic model and integrated immunity-analysis in pancreatic adenocarcinoma.
Wang H, Tian RF, Liang X, Fan J, Duan ZC, Fan XY, Zhang JJ, Yao DS, Chen ZN, Li L
Frontiers in oncology 2022;12:1015042
Frontiers in oncology 2022;12:1015042
Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.
Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, He J, Li P, Chen X, Ding W, Zhong J, Zeng Z, Xie Z, Liu J, Zu X
Cell death & disease 2022 Aug 30;13(8):749
Cell death & disease 2022 Aug 30;13(8):749
ORP5 promotes tumor metastasis via stabilizing c-Met in renal cell carcinoma.
Song L, Zhang L, Zhou Y, Shao X, Xu Y, Pei D, Wang Q
Cell death discovery 2022 Apr 21;8(1):219
Cell death discovery 2022 Apr 21;8(1):219
Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
Han Y, Ma R, Cao G, Liu H, He L, Tang L, Li H, Luo Q
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription.
Hou P, Lin T, Meng S, Shi M, Chen F, Jiang T, Li Z, Li M, Chu S, Zheng J, Bai J
International journal of biological sciences 2021;17(8):1979-1994
International journal of biological sciences 2021;17(8):1979-1994
Development and Validation of a Nomogram based on cell growth-related Biomarkers for Oral Squamous Cell Carcinoma.
Shuai Y, Duan Y, Zhou M, Yue K, Liu D, Fang Y, Wang Y, Wu Y, Zhang Z, Wang X
Journal of Cancer 2021;12(17):5153-5163
Journal of Cancer 2021;12(17):5153-5163
Hepatocyte Growth Factor Overexpression Slows the Progression of 4NQO-Induced Oral Tumorigenesis.
He X, Chen S, Tang Y, Zhao X, Yan L, Wu L, Wu Z, Liu W, Chen X, Wang X
Frontiers in oncology 2021;11:756479
Frontiers in oncology 2021;11:756479
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
Yuan Q, Liang Q, Sun Z, Yuan X, Hou W, Wang Y, Wang H, Yu M
Oncoimmunology 2021;10(1):1914954
Oncoimmunology 2021;10(1):1914954
Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy.
Li E, Huang X, Zhang G, Liang T
Journal of experimental & clinical cancer research : CR 2021 Sep 3;40(1):279
Journal of experimental & clinical cancer research : CR 2021 Sep 3;40(1):279
CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c-Met signaling pathway.
Zhao D, Yang Z, Chen C, Zhang Z, Yu Y, Li Z
FEBS open bio 2021 Nov;11(11):3115-3125
FEBS open bio 2021 Nov;11(11):3115-3125
Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer.
Ji J, Wang Z, Sun W, Li Z, Cai H, Zhao E, Cui H
International journal of molecular sciences 2021 Nov 9;22(22)
International journal of molecular sciences 2021 Nov 9;22(22)
miRNA in food simultaneously controls animal viral disease and human tumorigenesis.
Cui Y, Wan H, Zhang X
Molecular therapy. Nucleic acids 2021 Mar 5;23:995-1006
Molecular therapy. Nucleic acids 2021 Mar 5;23:995-1006
Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors.
Yuan X, Sun Z, Yuan Q, Hou W, Liang Q, Wang Y, Mo W, Wang H, Yu M
Investigational new drugs 2021 Feb;39(1):34-51
Investigational new drugs 2021 Feb;39(1):34-51
Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Dong X, Luo Y, Lu S, Ma H, Zhang W, Zhu Y, Sun G, Sun X
Clinical and translational medicine 2021 Feb;11(2):e296
Clinical and translational medicine 2021 Feb;11(2):e296
Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma.
Meng Y, Qian X, Zhao L, Li N, Wu S, Chen B, Sun T, Wang X
Cancer cell international 2021 Apr 15;21(1):216
Cancer cell international 2021 Apr 15;21(1):216
Tivantinib Decreases Hepatocyte Growth Factor-Induced BCRP Expression in Hepatocellular Carcinoma HepG2 Cells.
Kobayashi K, Higai K, Mukozu T, Matsui D, Amanuma M, Yoshimine N, Ogino Y, Matsui T, Wakui N, Shinohara M, Momiyama K, Daido Y, Nagai H, Igarashi Y
Biological & pharmaceutical bulletin 2020;43(9):1421-1425
Biological & pharmaceutical bulletin 2020;43(9):1421-1425
Adipose-Derived Stem Cells Promote Proliferation and Invasion in Cervical Cancer by Targeting the HGF/c-MET Pathway.
Zhai Y, Wu W, Xi X, Yu R
Cancer management and research 2020;12:11823-11832
Cancer management and research 2020;12:11823-11832
The long noncoding RNA FTX promotes a malignant phenotype in bone marrow mesenchymal stem cells via the miR-186/c-Met axis.
Liu L, Li X, Shi Y, Chen H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110666
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110666
Decorin promotes apoptosis and autophagy via suppressing c-Met in HTR-8 trophoblasts.
Wang Y, Zhang H, Zhang Y, Li X, Hu X, Wang X
Reproduction (Cambridge, England) 2020 May;159(6):669-677
Reproduction (Cambridge, England) 2020 May;159(6):669-677
Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors.
Xing M, Fu R, Liu Y, Wang P, Ma P, Zhu C, Fan D
Food & function 2020 May 1;11(5):4123-4137
Food & function 2020 May 1;11(5):4123-4137
Increased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met.
Chen JJ, Sun X, Mao QQ, Jiang XY, Zhao XG, Xu WJ, Zhong L
The Kaohsiung journal of medical sciences 2020 Mar;36(3):196-205
The Kaohsiung journal of medical sciences 2020 Mar;36(3):196-205
Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis.
Dong X, Kong F, Liu C, Dai S, Zhang Y, Xiao F, Zhang H, Wu CT, Wang H
Stem cell research & therapy 2020 Jun 10;11(1):229
Stem cell research & therapy 2020 Jun 10;11(1):229
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Chen Y, Tang J, Lu T, Liu F
Thoracic cancer 2020 Jul;11(7):1848-1860
Thoracic cancer 2020 Jul;11(7):1848-1860
CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
Ying Y, Li J, Xie H, Yan H, Jin K, He L, Ma X, Wu J, Xu X, Fang J, Wang X, Zheng X, Liu B, Xie L
Cell proliferation 2020 Feb;53(2):e12751
Cell proliferation 2020 Feb;53(2):e12751
SEMA3C Promotes Cervical Cancer Growth and Is Associated With Poor Prognosis.
Liu R, Shuai Y, Luo J, Zhang Z
Frontiers in oncology 2019;9:1035
Frontiers in oncology 2019;9:1035
Rosiglitazone Suppresses Calcium Oxalate Crystal Binding and Oxalate-Induced Oxidative Stress in Renal Epithelial Cells by Promoting PPAR-γ Activation and Subsequent Regulation of TGF-β1 and HGF Expression.
Liu YD, Yu SL, Wang R, Liu JN, Jin YS, Li YF, An RH
Oxidative medicine and cellular longevity 2019;2019:4826525
Oxidative medicine and cellular longevity 2019;2019:4826525
A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer.
Hou W, Yuan Q, Yuan X, Wang Y, Mo W, Wang H, Yu M
Investigational new drugs 2019 Oct;37(5):876-889
Investigational new drugs 2019 Oct;37(5):876-889
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Huang X, Gan G, Wang X, Xu T, Xie W
Autophagy 2019 Jul;15(7):1258-1279
Autophagy 2019 Jul;15(7):1258-1279
Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer.
Li J, Ying Y, Xie H, Jin K, Yan H, Wang S, Xu M, Xu X, Wang X, Yang K, Zheng X, Xie L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1374-1388
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jan;33(1):1374-1388
Clinicopathologic Features and Prognostic Factors in Alpha-Fetoprotein-Producing Colorectal Cancer: Analysis of 78 Cases.
Feng Y, Li Y, Dai W, Mo S, Li Q, Cai S
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(5):2052-2064
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(5):2052-2064
ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.
Yuan H, Zhou W, Yang Y, Xue L, Liu L, Song Y
Experimental cell research 2018 Jun 1;367(1):47-55
Experimental cell research 2018 Jun 1;367(1):47-55
Shrimp miR-34 from Shrimp Stress Response to Virus Infection Suppresses Tumorigenesis of Breast Cancer.
Cui Y, Yang X, Zhang X
Molecular therapy. Nucleic acids 2017 Dec 15;9:387-398
Molecular therapy. Nucleic acids 2017 Dec 15;9:387-398
SOCS1 regulates hepatic regenerative response and provides prognostic makers for acute obstructive cholangitis.
Yu J, Zhang W, Qian H, Tang H, Lin W, Lu B
Scientific reports 2017 Aug 25;7(1):9482
Scientific reports 2017 Aug 25;7(1):9482
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 25869-1-AP( MET Antibody) at dilution of 1:300
- Validation comment
- WB
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- IP Result of anti-MET (IP:25869-1-AP, 5ug; Detection:25869-1-AP 1:300) with HeLa cells lysate 1600ug.
- Validation comment
- IP
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 25869-1-AP( MET Antibody) at dilution of 1:50 (under 10x lens)
- Validation comment
- IHC
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 25869-1-AP( MET Antibody) at dilution of 1:50 (under 40x lens)
- Validation comment
- IHC