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Western blot
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Flow cytometry [1]
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- Product number
- BAF358 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal HGFR/c-MET Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human HGF R/c-MET in ELISAs and Western blots. In Western blot, this antibody shows approximately 50% cross-reactivity with recombinant mouse HGF R.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Biotin
- Isotype
- IgG
- Vial size
- 50 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Induction of MET Receptor Tyrosine Kinase Down-regulation through Antibody-mediated Receptor Clustering.
Tumor and Plasma Met Levels in Non-Metastatic Prostate Cancer.
A pharmacodynamic/pharmacokinetic study of ficlatuzumab in patients with advanced solid tumors and liver metastases.
The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.
Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors.
Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met-dependent tumors in animal models.
Li W, Dick A, Lu F, Zhang H, Sun H
Scientific reports 2019 Feb 13;9(1):1988
Scientific reports 2019 Feb 13;9(1):1988
Tumor and Plasma Met Levels in Non-Metastatic Prostate Cancer.
Kaye DR, Pinto PA, Cecchi F, Reilly J, Semerjian A, Rabe DC, Gupta G, Choyke PL, Bottaro DP
PloS one 2016;11(6):e0157130
PloS one 2016;11(6):e0157130
A pharmacodynamic/pharmacokinetic study of ficlatuzumab in patients with advanced solid tumors and liver metastases.
Tabernero J, Elez ME, Herranz M, Rico I, Prudkin L, Andreu J, Mateos J, Carreras MJ, Han M, Gifford J, Credi M, Yin W, Agarwal S, Komarnitsky P, Baselga J
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 May 15;20(10):2793-804
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 May 15;20(10):2793-804
The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.
Cen B, Xiong Y, Song JH, Mahajan S, DuPont R, McEachern K, DeAngelo DJ, Cortes JE, Minden MD, Ebens A, Mims A, LaRue AC, Kraft AS
Molecular and cellular biology 2014 Jul;34(13):2517-32
Molecular and cellular biology 2014 Jul;34(13):2517-32
Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors.
Gordon MS, Sweeney CS, Mendelson DS, Eckhardt SG, Anderson A, Beaupre DM, Branstetter D, Burgess TL, Coxon A, Deng H, Kaplan-Lefko P, Leitch IM, Oliner KS, Yan L, Zhu M, Gore L
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jan 15;16(2):699-710
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jan 15;16(2):699-710
Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met-dependent tumors in animal models.
Coxon A, Rex K, Meyer S, Sun J, Sun J, Chen Q, Radinsky R, Kendall R, Burgess TL
Molecular cancer therapeutics 2009 May;8(5):1119-25
Molecular cancer therapeutics 2009 May;8(5):1119-25
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of HGF R/c-MET in MDA-MB-231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Human HGF R/c-MET Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF358, filled histogram) or control antibody (Catalog # BAF108, open histogram), followed by Streptavidin-Allophycocyanin (Catalog # F0050).
