Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- AF527 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal HGFR/c-MET Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse HGF R/c-MET in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human (rh) HGF R and less than 1% cross-reactivity with rhMSP R is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Pulmonary pericytes regulate lung morphogenesis.
Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate.
Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.
Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing.
Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1.
Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.
MET is required for the recruitment of anti-tumoural neutrophils.
Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling.
Recombinant insulin-like growth factor-1 activates satellite cells in the mouse urethral rhabdosphincter.
Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling.
High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo.
c-Met and its ligand hepatocyte growth factor/scatter factor regulate mature B cell survival in a pathway induced by CD74.
Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
Purification and characterization of mouse lacrimal gland epithelial cells and reconstruction of an acinarlike structure in three-dimensional culture.
Possible implication of satellite cells in regenerative motoneuritogenesis: HGF upregulates neural chemorepellent Sema3A during myogenic differentiation.
A role for calcium-calmodulin in regulating nitric oxide production during skeletal muscle satellite cell activation.
Ets-1 triggers and orchestrates the malignant phenotype of mammary cancer cells within their matrix environment.
A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras.
A recombinant single-chain IL-7/HGFbeta hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells.
Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism.
Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor.
Kato K, Diéguez-Hurtado R, Park DY, Hong SP, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana JL, Koh GY, Adams RH
Nature communications 2018 Jun 22;9(1):2448
Nature communications 2018 Jun 22;9(1):2448
Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate.
Mi J, Hooker E, Balog S, Zeng H, Johnson DT, He Y, Yu EJ, Wu H, Le V, Lee DH, Aldahl J, Gonzalgo ML, Sun Z
The Journal of biological chemistry 2018 Dec 28;293(52):20123-20136
The Journal of biological chemistry 2018 Dec 28;293(52):20123-20136
Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.
Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robbez-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J, Kermorgant S
Nature communications 2016 Jun 23;7:11942
Nature communications 2016 Jun 23;7:11942
Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing.
Shibata S, Miwa T, Wu HH, Levitt P, Ohyama T
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Aug 3;36(31):8200-9
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Aug 3;36(31):8200-9
Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1.
Tesfay L, Schulz VV, Frank SB, Lamb LE, Miranti CK
Molecular biology of the cell 2016 Aug 1;27(15):2493-504
Molecular biology of the cell 2016 Aug 1;27(15):2493-504
Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.
Raymond WW, Xu X, Nimishakavi S, Le C, McDonald DM, Caughey GH
PloS one 2015;10(5):e0125797
PloS one 2015;10(5):e0125797
MET is required for the recruitment of anti-tumoural neutrophils.
Finisguerra V, Di Conza G, Di Matteo M, Serneels J, Costa S, Thompson AA, Wauters E, Walmsley S, Prenen H, Granot Z, Casazza A, Mazzone M
Nature 2015 Jun 18;522(7556):349-53
Nature 2015 Jun 18;522(7556):349-53
Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling.
Zoratti GL, Tanabe LM, Varela FA, Murray AS, Bergum C, Colombo É, Lang JE, Molinolo AA, Leduc R, Marsault E, Boerner J, List K
Nature communications 2015 Apr 15;6:6776
Nature communications 2015 Apr 15;6:6776
Recombinant insulin-like growth factor-1 activates satellite cells in the mouse urethral rhabdosphincter.
Wei W, Howard PS, Macarak EJ
BMC urology 2013 Nov 26;13:62
BMC urology 2013 Nov 26;13:62
Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling.
Tesio M, Golan K, Corso S, Giordano S, Schajnovitz A, Vagima Y, Shivtiel S, Kalinkovich A, Caione L, Gammaitoni L, Laurenti E, Buss EC, Shezen E, Itkin T, Kollet O, Petit I, Trumpp A, Christensen J, Aglietta M, Piacibello W, Lapidot T
Blood 2011 Jan 13;117(2):419-28
Blood 2011 Jan 13;117(2):419-28
High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo.
Yamada M, Tatsumi R, Yamanouchi K, Hosoyama T, Shiratsuchi S, Sato A, Mizunoya W, Ikeuchi Y, Furuse M, Allen RE
American journal of physiology. Cell physiology 2010 Mar;298(3):C465-76
American journal of physiology. Cell physiology 2010 Mar;298(3):C465-76
c-Met and its ligand hepatocyte growth factor/scatter factor regulate mature B cell survival in a pathway induced by CD74.
Gordin M, Tesio M, Cohen S, Gore Y, Lantner F, Leng L, Bucala R, Shachar I
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 15;185(4):2020-31
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 15;185(4):2020-31
Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
Moransard M, Sawitzky M, Fontana A, Suter T
Glia 2010 Apr;58(5):559-71
Glia 2010 Apr;58(5):559-71
Purification and characterization of mouse lacrimal gland epithelial cells and reconstruction of an acinarlike structure in three-dimensional culture.
Ueda Y, Karasawa Y, Satoh Y, Nishikawa S, Imaki J, Ito M
Investigative ophthalmology & visual science 2009 May;50(5):1978-87
Investigative ophthalmology & visual science 2009 May;50(5):1978-87
Possible implication of satellite cells in regenerative motoneuritogenesis: HGF upregulates neural chemorepellent Sema3A during myogenic differentiation.
Tatsumi R, Sankoda Y, Anderson JE, Sato Y, Mizunoya W, Shimizu N, Suzuki T, Yamada M, Rhoads RP Jr, Ikeuchi Y, Allen RE
American journal of physiology. Cell physiology 2009 Aug;297(2):C238-52
American journal of physiology. Cell physiology 2009 Aug;297(2):C238-52
A role for calcium-calmodulin in regulating nitric oxide production during skeletal muscle satellite cell activation.
Tatsumi R, Wuollet AL, Tabata K, Nishimura S, Tabata S, Mizunoya W, Ikeuchi Y, Allen RE
American journal of physiology. Cell physiology 2009 Apr;296(4):C922-9
American journal of physiology. Cell physiology 2009 Apr;296(4):C922-9
Ets-1 triggers and orchestrates the malignant phenotype of mammary cancer cells within their matrix environment.
Furlan A, Vercamer C, Desbiens X, Pourtier A
Journal of cellular physiology 2008 Jun;215(3):782-93
Journal of cellular physiology 2008 Jun;215(3):782-93
A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras.
Yang Y, Wislez M, Fujimoto N, Prudkin L, Izzo JG, Uno F, Ji L, Hanna AE, Langley RR, Liu D, Johnson FM, Wistuba I, Kurie JM
Molecular cancer therapeutics 2008 Apr;7(4):952-60
Molecular cancer therapeutics 2008 Apr;7(4):952-60
A recombinant single-chain IL-7/HGFbeta hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells.
Lai L, Zeff RA, Goldschneider I
Blood 2006 Mar 1;107(5):1776-84
Blood 2006 Mar 1;107(5):1776-84
Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism.
Hoffmann KM, Tapia JA, Berna MJ, Thill M, Braunschweig T, Mantey SA, Moody TW, Jensen RT
The Journal of biological chemistry 2006 Dec 8;281(49):37705-19
The Journal of biological chemistry 2006 Dec 8;281(49):37705-19
Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor.
Dong G, Lee TL, Yeh NT, Geoghegan J, Van Waes C, Chen Z
Oncogene 2004 Aug 19;23(37):6199-208
Oncogene 2004 Aug 19;23(37):6199-208
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- HGF R/c-MET in Mouse Embryo. HGF R/c-MET in Mouse Embryo.