Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11671-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11671-1-AP, RRID:AB_2173437
- Product name
- RAB1A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RAB1A antibody (Cat. #11671-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A guide to selecting high-performing antibodies for Rab1A and Rab1B for use in Western Blot, immunoprecipitation and immunofluorescence.
TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy.
Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence.
Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction.
Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.
Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer.
RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition.
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
CircRNA circ-0038718 promotes hepatocellular carcinoma progression through sponging miR-139-3p.
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells.
Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer.
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Tissue-based quantitative proteome analysis of human hepatocellular carcinoma using tandem mass tags.
Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.
Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.
Rab1A is an mTORC1 activator and a colorectal oncogene.
Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome.
Ruíz Moleón V, Fotouhi M, Ayoubi R, González Bolívar S, Southern K, McPherson PS, Laflamme C, NeuroSGC/YCharOS/EDDU collaborative group, ABIF consortium
F1000Research 2023;12:1578
F1000Research 2023;12:1578
TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
Yao W, Chen Y, Chen Y, Zhao P, Liu J, Zhang Y, Jiang Q, Wu C, Xie Y, Fan S, Ye M, Wang Y, Feng Y, Bai X, Fan M, Feng S, Wang J, Cui Y, Xia H, Ma C, Xie Z, Zhang L, Sun Q, Liu W, Yi C
The EMBO journal 2023 Oct 4;42(19):e112814
The EMBO journal 2023 Oct 4;42(19):e112814
Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy.
Sun Y, Zheng H, Qian L, Liu Y, Zhu D, Xu Z, Chang W, Xu J, Wang L, Sun B, Gu L, Yuan H, Lou H
JACS Au 2023 Oct 23;3(10):2749-2762
JACS Au 2023 Oct 23;3(10):2749-2762
Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence.
Gyurkovska V, Murtazina R, Zhao SF, Shikano S, Okamoto Y, Segev N
Life science alliance 2023 May;6(5)
Life science alliance 2023 May;6(5)
Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction.
Deng D, Qu Y, Sun L, Jia L, Bu J, Ye M, Chen Z, Geng Y, Zhou S, Fang B
Frontiers in pharmacology 2021;12:616165
Frontiers in pharmacology 2021;12:616165
Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.
Zhang X, Wang X, Yuan Z, Radford SJ, Liu C, Libutti SK, Zheng XFS
Cell reports 2021 Mar 16;34(11):108830
Cell reports 2021 Mar 16;34(11):108830
Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer.
Huang T, Chen B, Wang F, Cai W, Wang X, Huang B, Liu F, Jiang B, Zhang Y
Cancer letters 2021 Dec 28;523:182-194
Cancer letters 2021 Dec 28;523:182-194
RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition.
Ren B, Wang L, Nan Y, Liu T, Zhao L, Ma H, Li J, Zhang Y, Ren X
Future oncology (London, England) 2021 Aug;17(24):3203-3216
Future oncology (London, England) 2021 Aug;17(24):3203-3216
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Peng C, Li X, Ye Z, Wu W
Scientific reports 2021 Aug 10;11(1):16243
Scientific reports 2021 Aug 10;11(1):16243
CircRNA circ-0038718 promotes hepatocellular carcinoma progression through sponging miR-139-3p.
Sun R, Li H, Li J, Shen S, Cui G, Dong G
Biochemical and biophysical research communications 2020 Dec 17;533(4):845-852
Biochemical and biophysical research communications 2020 Dec 17;533(4):845-852
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells.
Ding X, Jiang X, Tian R, Zhao P, Li L, Wang X, Chen S, Zhu Y, Mei M, Bao S, Liu W, Tang Z, Sun Q
Autophagy 2019 Oct;15(10):1774-1786
Autophagy 2019 Oct;15(10):1774-1786
Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer.
Cheng Z, Shao X, Xu M, Wang J, Kuai X, Zhang L, Wu J, Zhou C, Mao J
Oncology reports 2019 May;41(5):2717-2728
Oncology reports 2019 May;41(5):2717-2728
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Xu H, Qian M, Zhao B, Wu C, Maskey N, Song H, Li D, Song J, Hua K, Fang L
Oncology reports 2017 Mar;37(3):1619-1626
Oncology reports 2017 Mar;37(3):1619-1626
Tissue-based quantitative proteome analysis of human hepatocellular carcinoma using tandem mass tags.
Megger DA, Rosowski K, Ahrens M, Bracht T, Eisenacher M, Schlaak JF, Weber F, Hoffmann AC, Meyer HE, Baba HA, Sitek B
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2017 Mar;22(2):113-122
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2017 Mar;22(2):113-122
Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.
Wang X, Liu F, Qin X, Huang T, Huang B, Zhang Y, Jiang B
Aging 2016 Nov 29;8(11):2790-2798
Aging 2016 Nov 29;8(11):2790-2798
Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.
Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Özdinler PH
Human molecular genetics 2016 Mar 15;25(6):1074-87
Human molecular genetics 2016 Mar 15;25(6):1074-87
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
Sellier C, Campanari ML, Julie Corbier C, Gaucherot A, Kolb-Cheynel I, Oulad-Abdelghani M, Ruffenach F, Page A, Ciura S, Kabashi E, Charlet-Berguerand N
The EMBO journal 2016 Jun 15;35(12):1276-97
The EMBO journal 2016 Jun 15;35(12):1276-97
Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.
Smith GA, Rocha EM, McLean JR, Hayes MA, Izen SC, Isacson O, Hallett PJ
Human molecular genetics 2014 Sep 1;23(17):4510-27
Human molecular genetics 2014 Sep 1;23(17):4510-27
Rab1A is an mTORC1 activator and a colorectal oncogene.
Thomas JD, Zhang YJ, Wei YH, Cho JH, Morris LE, Wang HY, Zheng XF
Cancer cell 2014 Nov 10;26(5):754-69
Cancer cell 2014 Nov 10;26(5):754-69
Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome.
Campbell-Valois FX, Trost M, Chemali M, Dill BD, Laplante A, Duclos S, Sadeghi S, Rondeau C, Morrow IC, Bell C, Gagnon E, Hatsuzawa K, Thibault P, Desjardins M
Molecular & cellular proteomics : MCP 2012 Jul;11(7):M111.016378
Molecular & cellular proteomics : MCP 2012 Jul;11(7):M111.016378
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 11671-1-AP(RAB1A antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RAB1A antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RAB1A. This antibody recognizes human,mouse,rat antigen. The RAB1A antibody has been validated for the following applications: ELISA, WB, IHC analysis.