10222-1-AP

antibody from Proteintech Group

Targeting: KHDRBS1 FLJ34027, p62, Sam68

Provider product page for 10222-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [16]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 10222-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10222-1-AP, RRID:AB_2130292
Product name: Sam68 antibody
Antibody type: Polyclonal
Description: Sam68 antibody (Cat. #10222-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

KHDRBS1 protein structure - 10222-1-AP shown in red.

Submitted references The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis.

Meng K, Li Y, Yuan X, Shen HM, Hu LL, Liu D, Shi F, Zheng D, Shi X, Wen N, Cao Y, Pan YL, He QY, Zhang CZ
Signal transduction and targeted therapy 2025 Jan 27;10(1):43

CDC5L binds to ELAVL1 to inhibit pyroptosis in hepatocellular carcinoma through the Caspase 3/GSDME signaling pathway.

Liang S, Zhu Z, Tang Y, Zhou S, Xiao M, Gong X, Ye K
International journal of molecular medicine 2025 Dec;56(6)

Hypoxia-Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O-GlcNAcylation.

Zhang P, Luo Z, Xu Y, Zhang Y, Zhang R, Paerhati N, Zhang S, Cai Q, Qiu Z, Huang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e05396

CD44v5 enhances the IL-4/IL-4Rα/STAT6/SAM68 aix inducing M2 polarization and promoting triple-negative breast cancer progression.

Ji Z, Wang L, Bao X, Dai Y, Jiang M, Ma H, Li N, Yang C
Cancer biology & therapy 2025 Dec 31;26(1):2589658

Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.

Gao M, Shen H, Li Q, Gu X, Jia T, Wang Y
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333

TFEB regulates the odontoblastic differentiation of dental pulp stem cells by promoting a positive feedback loop between mitophagy and glycolysis.

Li Y, Yang E, Geng Y, Li M, Wang X, Zhang D
Archives of oral biology 2024 Apr;160:105909

CircMTA1 promotes glioblastoma angiogenesis by encoding MTA1-134aa.

Niu B, Wei D, Liu XY, Zhai B, Liu XB, Yao YL, Xue YX, Wang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23160

HnRNPR strongly represses splicing of a critical exon associated with spinal muscular atrophy through binding to an exonic AU-rich element.

Jiang T, Qu R, Liu X, Hou Y, Wang L, Hua Y
Journal of medical genetics 2023 Nov;60(11):1105-1115

ZnO nanoparticles impair autophagic flux and cell viability through the TRIM16-NRF2-p62 pathway in inflammatory keratinocytes.

Wang M, Zheng H, Chen J, Tang Y, Feng M, Li L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114177

Shortening of the KHDRBS1 3'UTR by alternative cleavage and polyadenylation alters miRNA-mediated regulation and promotes gastric cancer progression.

Yu X, Kang W, Zhang J, Chen C, Liu Y
American journal of translational research 2022;14(9):6574-6585

Lipophagy-ICAM-1 pathway associated with fatty acid and oxygen deficiencies is involved in poor prognoses of ovarian clear cell carcinoma.

Koizume S, Takahashi T, Nakamura Y, Yoshihara M, Ota Y, Sato S, Tadokoro H, Yokose T, Kato H, Miyagi E, Miyagi Y
British journal of cancer 2022 Aug;127(3):462-473

SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing.

Zhu S, Chen W, Wang J, Qi L, Pan H, Feng Z, Tian D
Theranostics 2021;11(7):3359-3375

LRRC4 mediates the formation of circular RNA CD44 to inhibitGBM cell proliferation.

Feng J, Ren X, Fu H, Li D, Chen X, Zu X, Liu Q, Wu M
Molecular therapy. Nucleic acids 2021 Dec 3;26:473-487

Cold-induced RNA-binding protein (CIRBP) regulates the expression of Src-associated during mitosis of 68 kDa (Sam68) and extracellular signal-regulated kinases (ERK) during heat stress-induced testicular injury.

Xu C, Ke D, Zou L, Li N, Wang Y, Fan X, Zhu C, Xia W
Reproduction, fertility, and development 2020 Dec;32(18):1357-1364

Regulatory T cells delay disease progression in Alzheimer-like pathology.

Dansokho C, Ait Ahmed D, Aid S, Toly-Ndour C, Chaigneau T, Calle V, Cagnard N, Holzenberger M, Piaggio E, Aucouturier P, Dorothée G
Brain : a journal of neurology 2016 Apr;139(Pt 4):1237-51

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Neumann M, Valori CF, Ansorge O, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ishihara K, Ang LC, Bilbao JM, Mackenzie IR
Acta neuropathologica 2012 Nov;124(5):705-16

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 10222-1-AP(KHDRBS1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of MCF-7 cells, using KHDRBS1 antibody 10222-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 10222-1-AP(KHDRBS1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue