Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- sc-5593 - Provider product page
- Provider
- Santa Cruz Biotechnology
- Proper citation
- Santa Cruz Biotechnology Cat#sc-5593, RRID:AB_2151246
- Product name
- Anti-NOTCH3
- Antibody type
- Polyclonal
- Antigen
- Recombinant full-length protein
- Reactivity
- Human
- Host
- Rabbit
Submitted references The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice.
Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.
Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer.
Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium.
Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1.
Yang Y, Ahn YH, Gibbons DL, Zang Y, Lin W, Thilaganathan N, Alvarez CA, Moreira DC, Creighton CJ, Gregory PA, Goodall GJ, Kurie JM
The Journal of clinical investigation 2011 Apr;121(4):1373-85
The Journal of clinical investigation 2011 Apr;121(4):1373-85
Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.
Chen J, Kesari S, Rooney C, Strack PR, Chen J, Shen H, Wu L, Griffin JD
Genes & cancer 2010 Aug;1(8):822-35
Genes & cancer 2010 Aug;1(8):822-35
Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer.
Park JT, Shih IeM, Wang TL
Cancer research 2008 Nov 1;68(21):8852-60
Cancer research 2008 Nov 1;68(21):8852-60
Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium.
Rodriguez S, Sickles HM, Deleonardis C, Alcaraz A, Gridley T, Lin DM
Developmental biology 2008 Feb 1;314(1):40-58
Developmental biology 2008 Feb 1;314(1):40-58
Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1.
Jensen CH, Jauho EI, Santoni-Rugiu E, Holmskov U, Teisner B, Tygstrup N, Bisgaard HC
The American journal of pathology 2004 Apr;164(4):1347-59
The American journal of pathology 2004 Apr;164(4):1347-59
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Supportive validation
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- Experimental details
- Immunohistochemical staining of human small intestine shows strong nuclear and moderate cytoplasmic positivity in glandular cells.
- Validation comment
- Staining pattern partly consistent with experimental and/or bioinformatic data.