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- Product number
- 14088-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14088-1-AP, RRID:AB_2255217
- Product name
- SREBF1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SREBF1 antibody (Cat. #14088-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis.
Identification of the Antioxidant Enzyme B166 as a Novel Biomarker for Patients With Glioblastoma Multiforme.
Gut-Derived Hippuric Acid Alleviates Hepatic Lipid Metabolism via UGDH/FOXK1/CD36 Axis in Obese Mice.
Intermittent fasting ameliorates MAFLD by downregulating Lrg1: insights from bulk RNA sequencing and functional verification.
Iron overload reprogramming lipid metabolism through the IRP1-SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis.
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Integrated Proteomics and Metabolomics Reveal the Direct Hepatic Protection of Propionate Against Alcoholic Liver Disease via the RGN-PPARα Pathway.
TFAP2A regulates SGPP2 transcription to promote lipid accumulation and activate the Wnt/β-catenin signaling pathway to promote malignant progression in lung adenocarcinoma.
Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes.
METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion.
Chemerin Promotes Oral Squamous Cell Carcinoma Progression via NLRP3-Mediated Pyroptosis and the GSDMD-N Pathway.
Momordin Ic targets SREBP1 to disrupt lipid homeostasis and trigger synergistic apoptosis-ferroptosis in triple-negative breast cancer.
Farrerol ameliorates hepatic insulin resistance via AMPKα1/mTOR/SREBP-1 pathway: A study in T2DM rat models and palmitic acid-induced BRL 3 A hepatocytes.
Multi-omics integration reveals the ameliorative effects and underlying mechanisms of Astragalus membranaceus (Huangqi)-Fuzhuan brick tea on nonalcoholic fatty liver disease.
Integrating IDEAL-IQ Sequence with Mass Spectrometry Imaging for Profiling Lipid-Related Metabolic Reprogramming of Acute Kidney Injury.
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
The YAP/SCAP/SREBP1 pathway in astrocytes: A novel target for treating neonatal hypoxic-ischemic encephalopathy.
Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development.
KDM5B cooperates with CRL4B complex to promote the tumorigenesis of ER+ breast cancer via regulating cholesterol metabolism.
Paeoniflorin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Inhibiting Hepatic Lipogenesis and Inflammation.
Macrophage-derived IL-6 reprograms lipid metabolism to promote colorectal cancer development through USP14-mediated FASN deubiquitination.
FOXN3 integrates the KU70/KU80/SREBP-1 complex to regulate lipid metabolism in non-alcoholic fatty liver disease.
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.
Baicalein alleviates hepatic lipid metabolism disorders via the PPARα-FGF21-adiponectin axis: Regulating crosstalk between the liver and adipose tissue.
FTO mediates m6A demethylation of HNF1A and drives hepatic steatosis in metabolic dysfunction-associated steatotic liver disease.
Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy.
Rabdosia rubescens Inhibits CYP7A1 Expression and Induces Autophagy to Reduce Alcohol-Induced Liver Damage in Mice.
Unraveling SREBF1's role in elevating colorectal cancer prognosis through proliferation and migration inhibition.
Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy.
An integrative pharmacology-based study on the pharmacological activity and mechanism of xiaoji-chenpi formula (XCF) against MAFLD.
Brexpiprazole inhibits EMT and migration of colorectal cancer cells by downregulating the SREBP1/SNAI1 signaling pathway.
Reduction in within-litter variation of piglet birth weight through dietary supplementation of 3-hydroxyisobutyric acid in sows.
Insights Into the Mechanism of Action for Qingzhi Decoction for the Treatment of Non-Alcoholic Fatty Liver Disease via Regulation of the IRS/PI3K/Akt Signaling Pathway and the NRLP3 Inflammasome.
NDRG2 regulates milkfatbiosynthesis by targeting the AMPK/SREBP1 axis in bovine mammary epithelial cells.
CHAF1A Promotes Preadipocyte Differentiation and Contributes to Macrosomia in Gestational Diabetes Mellitus.
Cigarette smoke-induced PPAR signaling dysregulation accelerates Alzheimer's disease pathogenesis and cognitive decline in 5xFAD mice.
Choline reduces inflammatory response and lipid accumulation in calf hepatocytes induced by NEFA via inhibiting ROS/ NF-κB/NLRP3 inflammasome axis.
The 5-Aminolevulinic Acid Photodynamic Therapy Modulates Lipid Production by Protein Kinase B/JunD-Mediated NR4A1 Activation in the Treatment of Acne Vulgaris.
SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1-Mediated Transactivation of CD47.
Betaine decreases hepatic lipid deposition through DNA 5 mC and RNA m(6)A methylation-mediated regulation of fatty acid metabolic genes expression in laying hens.
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Mastitis via NCOA4-Mediated Ferritinophagy.
Saponin from Tea (Camellia sinensis) Seed Meal Attenuates Cortisol-Induced Lipogenesis and Inflammation in Human Cells.
Breviscapine regulates lipid metabolism of microglia via the ADORA1/PPARα/ACOX1 pathway to promote spinal cord injury recovery.
Enhanced bioactivity of honeysuckle-Cassia seeds extracts through Lactobacillus acidophilus and Bacillus subtilis co-fermentation: Impact on alcoholic liver disease and gut microbiota.
SLC25A40 promotes NSCLC growth by enhancing NADPH-mediated lipid synthesis and suppressing ROS accumulation-induced ferroptosis.
Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway.
Androgen regulates seasonal changes in triglyceride synthesis through the AR-SREBP1-FASN axis in the scented glands of muskrats (Ondatra zibethicus).
Network pharmacology and transcriptomics reveal complanatoside A regulates lipid metabolism in hyperlipidemia and nonalcoholic fatty liver disease via the AMPK pathway.
RUNX2 cooperates with SREBP1 to rewire cancer metabolism and promote aggressiveness.
Imidacloprid contributes to bladder cancer progression: preliminary evidence based on network toxicology, machine learning and molecular docking.
Growth hormone excess drives liver aging via increased glycation stress.
Collagen peptides from Skipjack tuna (Katsuwonus pelamis) bones: Composition, characterization, and mechanism of high-fat diet-induced NAFLD amelioration.
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
Genome-Wide Network Analysis of DRG-Sciatic Nerve Network-Inferred Cellular Senescence and Senescence Phenotype in Peripheral Sensory Neurons.
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
Steam explosion modified pea peptides alleviates hepatosteatosis by regulating lipid metabolism pathways and promoting autophagy.
A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes.
Alkannin triggered apoptosis and ferroptosis in gastric cancer by suppressing lipid metabolism mediated by the c-Fos/SREBF1 axis.
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
The Splice Variant of the NCOR2 Gene BQ323636.1 Modulates ACSL4 Expression to Enhance Fatty Acid Metabolism and Support of Tumor Growth in Breast Cancer.
Hepatic HSD17B6 is dispensable for diet-induced fatty liver disease in mice.
The effects of citalopram and sertraline on adipogenesis and lipogenesis in 3T3-L1 cells.
RORα fine-tunes the circadian control of hepatic triglyceride synthesis and gluconeogenesis.
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation.
Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver.
NCOA6 knockdown enhances RSL3-induced ferroptosis in pancreatic cancer cells and increases the sensitivity to gemcitabine.
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
CD36 molecule and AMP-activated protein kinase signaling drive docosahexaenoic acid-induced lipid remodeling in goat mammary epithelial cells.
Linghe granules reduces hepatic lipid accumulation in Non-alcoholic fatty liver disease through regulating lipid metabolism and redox balance.
Hawthorn total flavonoids ameliorate hyperlipidemia through AMPK/SREBP1-c and PPARα/PGC-1α/CPT-1A pathway activation and gut microbiota modulation.
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
Effects of Long-Term Blue Light Exposure on Body Fat Synthesis and Body Weight Gain in Mice and the Inhibitory Effect of Tranexamic Acid.
Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function.
KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy.
Multiomics analysis revealed the regulatory role of chenodeoxycholic acid in fatty acid metabolism and lipid homeostasis.
Foxk2 Enhances Adipogenic Differentiation by Relying on the Transcriptional Activation of Peroxisome Proliferator-Activated Receptor Gamma.
Acute heat stress regulates estradiol synthesis in ovine ovarian granulosa cells through the SREBPs/MVK-LHR pathway.
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication.
Bisphenol S Induces Lipid Metabolism Disorders in HepG2 and SK-Hep-1 Cells via Oxidative Stress.
Floralozone attenuates atherosclerotic vascular injury by regulating AMPKα/SREBP-1c pathway and down-regulating miR-33-5p.
Klebsiella pneumoniae causes mammary gland damage via FNIP1-mediated mitochondrial dysfunction.
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.
DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway.
Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping.
Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9.
Identification of Novel 58-5p and SREBF1 Interaction and Effects on Apoptosis of Ovine Ovarian Granulosa Cell.
Melittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism.
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
Rno-miR-130b Attenuates Lipid Accumulation Through Promoting Apoptosis and Inhibiting Differentiation in Rat Intramuscular Adipocytes.
Mechanism of O-GlcNAcylation regulating liver lipid synthesis in mice through FASN.
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Energy Stress-Induced circEPB41(2) Promotes Lipogenesis in Hepatocellular Carcinoma.
Transcriptome Reveals the Promoting Effect of Beta-Sitosterol on the Differentiation of Bovine Preadipocytes.
Cepharanthine relieves nonalcoholic steatohepatitis through inhibiting STAT1/CXCL10 axis-mediated lipogenesis and inflammatory responses.
Perilipin1 mediates milk fat synthesis in bovine mammary epithelial cells through SREBP1 phosphorylation.
Glyoxalase 1 is a proadipogenic gene.
Tryptophan derivatives as non-invasive diagnostic indicators for obesity-related MASLD in children and adolescents.
Triterpenoid saponins from Ilex latifolia inhibit breast cancer growth by disrupting the SREBP1/FASN-mediated lipid metabolic pathway.
Leukocyte immunoglobulin-like receptor B2 regulates atherosclerosis progression by modulating macrophage extracellular trap formation in foam macrophages through the PI3K-AKT signaling pathway.
Gut-liver axis mechanisms of Hippophae rhamnoides L. in non-alcoholic fatty liver disease prevention.
An ATF3 Inducer Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease Through the AMPK and PKA Pathways.
Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer.
The protein denitrosylase SCoR2 regulates lipogenesis and fat storage.
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma.
Lipid metabolism reprograming by SREBP1-PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy.
Biomimetic membrane-coated nanoparticles for targeted synergistic therapy of homocysteine-induced atherosclerosis: Dual modulation of cholesterol efflux and reactive oxygen species scavenging.
Newcastle disease virus induces degradation of folliculin to regulate host cell energy metabolism and facilitate viral replication.
Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis.
Helicobacter hepaticus promotes hepatic steatosis through CdtB-induced mitochondrial stress and lipid metabolism reprogramming.
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression.
Isoliquiritigenin suppresses fatty acid synthesis and cancer cell migration in anaplastic thyroid carcinoma through AMPK/SREBF1 pathway.
IRX5 Promoted SREBP1-Mediated de Novo Fatty Acid Synthesis via HMGN4 in Hepatocellular Carcinoma.
Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway.
Darolutamide-mediated phospholipid remodeling induces ferroptosis through the SREBP1-FASN axis in prostate cancer.
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
THSR Mediated MiR374b Targeting C/EBP β/FOXO1 to Accelerate Thyroid Stimulating Hormone-Induced Hepatic Steatosis.
Identification of proteins related to SIS3 by iTRAQ and PRM-based comparative proteomic analysis in cisplatin-induced acute kidney injury.
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism.
Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism.
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Dietary curcumin supplementation attenuates hepatic damage and function abnormality in a chronic corticosterone-induced stress model in broilers.
Potential Anti-Obesity Effect of Hazel Leaf Extract in Mice and Network Pharmacology of Selected Polyphenols.
Integrated single-cell and spatial transcriptomics reveal microenvironment disruptions by androgen in mouse ovary.
STAMBPL1, transcriptionally regulated by SREBP1, promotes malignant behaviors of hepatocellular carcinoma cells via Wnt/β-catenin signaling pathway.
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E-deficient mice.
Polyamines mediate cellular energetics and lipid metabolism through mitochondrial respiration to facilitate virus replication.
Macrophage-Hepatocyte Circuits Mediated by Grancalcin Aggravate the Progression of Metabolic Dysfunction Associated Steatohepatitis.
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Protective Effects of Isostrictiniin Against High-Fat, High-Sugar Diet-Induced Steatosis in MASLD Mice via Regulation of the AMPK/SREBP-1c/ACC Pathway.
Midkine as a driver of age-related changes and increase in mammary tumorigenesis.
NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA.
Histone MARylation regulates lipid metabolism in colorectal cancer by promoting IGFBP1 methylation.
Toosendanin induces hepatotoxicity via disrupting LXRα/Lipin1/SREBP1 mediated lipid metabolism.
Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion.
Effect of LncRNA LOC106505926 on myogenesis and Lipogenesis of porcine primary cells.
Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis.
Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways.
Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes.
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma.
RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid.
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis.
Curcumin supplementation alleviates hepatic fat content associated with modulation of gut microbiota-dependent bile acid metabolism in patients with nonalcoholic simple fatty liver disease: a randomized controlled trial.
Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis.
Stigmasterol Activates the mTOR Signaling Pathway by Inhibiting ORP5 Ubiquitination to Promote Milk Synthesis in Bovine Mammary Epithelial Cells.
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.
Bta-miR-200a Regulates Milk Fat Biosynthesis by Targeting IRS2 to Inhibit the PI3K/Akt Signal Pathway in Bovine Mammary Epithelial Cells.
Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease.
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
DNAJA1 positively regulates amino acid-stimulated milk protein and fat synthesis in bovine mammary epithelial cells.
Valine promotes milk synthesis by regulating PKM2 nuclear accumulation and histone H3 acetylation through the TAS1R1-mTOR-DDX39B signaling pathway.
6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway.
Si-Ni-San inhibits hepatic Fasn expression and lipid accumulation in MAFLD mice through AMPK/p300/SREBP-1c axis.
NAMPT promotes the malignant progression of HBV-associated hepatocellular carcinoma through activation of SREBP1-mediated lipogenesis.
Stigmasterol and gastrodin, two major components of banxia-baizhu-tianma decoction, alleviated the excessive phlegm-dampness hypertension by reducing lipid accumulation.
Dietary manganese supplementation decreases hepatic lipid deposition by regulating gene expression and enzyme activity involved in lipid metabolism in the liver of broilers.
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Acylated Ghrelin Activates PI3K/mTOR Signaling Pathway by Promoting ThPOK Acetylation to Promote Milk Fat Synthesis in Bovine Mammary Epithelial Cells.
Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate.
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Comprehensive Analysis of Transcriptome and Metabolome Reveals Regulatory Mechanism of Intramuscular Fat Content in Beef Cattle.
PEDV inhibits HNRNPA3 expression by miR-218-5p to enhance cellular lipid accumulation and promote viral replication.
Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice.
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment.
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Hepatic miR-363 promotes nonalcoholic fatty liver disease by suppressing INSIG1.
Activated PARP1/FAK/COL5A1 signaling facilitates the tumorigenesis of cholesterol-resistant ovarian cancer cells through promoting EMT.
Pharmacological inhibition of SREBP1 suppresses pancreatic cancer growth via inducing GPX4-mediated ferroptosis.
Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy.
Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice.
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy.
A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy.
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics.
Regulatory effect of β-glucan secreted by Rhizobium pusense on triglyceride metabolism and their relationships with the modulation of intestinal microbiota in mice fed a high-fat diet.
Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis.
PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8(+)T cells.
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway.
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Hepatotoxicity induced in rats by chronic exposure to F-53B, an emerging replacement of perfluorooctane sulfonate (PFOS).
Bufalin Inhibits Tumorigenesis and SREBP-1-Mediated Lipogenesis in Hepatocellular Carcinoma via Modulating the ATP1A1/CA2 Axis.
The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity.
Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice.
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
Double-edged effect of sodium citrate in Nile tilapia (Oreochromis niloticus): Promoting lipid and protein deposition vs. causing hyperglycemia and insulin resistance.
High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression.
Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2.
Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.
In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages.
Withdrawal.
Photochemistry and photobiology 2023 Nov-Dec;99(6):1501
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis.
ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells.
Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection.
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma.
Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation.
ARID3A plays a key regulatory role in palmitic acid-stimulated milk fat synthesis in mouse mammary epithelial cells.
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis.
ORP5 promotes migration and invasion of cervical cancer cells by inhibiting endoplasmic reticulum stress.
Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway.
Sclareol ameliorates liver injury by inhibiting nuclear factor-kappa B/NOD-like receptor protein 3-mediated inflammation and lipid metabolism disorder in diabetic mice.
Goat FADS2 controlling fatty acid metabolism is directly regulated by SREBP1 in mammary epithelial cells.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes.
Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway.
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
miR-33a Inhibits the Differentiation of Bovine Preadipocytes through the IRS2-Akt Pathway.
Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells.
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
3D artificial sebocyte glands from inertial focusing effect for facile and flexible analysis of light damage and drug screening.
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway.
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
DAXX drives de novo lipogenesis and contributes to tumorigenesis.
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Roxadustat, a Hypoxia-Inducible Factor 1α Activator, Attenuates Both Long- and Short-Term Alcohol-Induced Alcoholic Liver Disease.
Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway.
The interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis.
Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.
GPRC6A is a key mediator of palmitic acid regulation of lipid synthesis in bovine mammary epithelial cells.
SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs.
Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma.
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells.
Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling.
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
METTL3 is a key regulator of milk synthesis in mammary epithelial cells.
Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).
The lncRNA ZFAS1 regulates lipogenesis in colorectal cancer by binding polyadenylate-binding protein 2 to stabilize SREBP1 mRNA.
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway.
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
Divergent transcriptional regulation of astrocyte reactivity across disorders.
Amelioration action of gastrodigenin rhamno-pyranoside from Moringa seeds on non-alcoholic fatty liver disease.
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis.
A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD.
Elevated thyroid hormones caused by high concentrate diets participate in hepatic metabolic disorders in dairy cows.
Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.
Redox-Unlockable Nanoparticle-Based MST1 Delivery System to Attenuate Hepatic Steatosis via the AMPK/SREBP-1c Signaling Axis.
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Stearic Acid Activates the PI3K-mTOR-4EBP1/S6K and mTOR-SREBP-1 Signaling Axes through FATP4-CDK1 To Promote Milk Synthesis in Primary Bovine Mammary Epithelial Cells.
Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression.
SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation.
L-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice.
L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway.
The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes.
BRG1 Links TLR4 Trans-Activation to LPS-Induced SREBP1a Expression and Liver Injury.
Multi-Omics Analysis of Mammary Metabolic Changes in Dairy Cows Exposed to Hypoxia.
An Integrated Transcriptomics and Proteomics Analysis Implicates lncRNA MALAT1 in the Regulation of Lipid Metabolism.
Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice.
JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathway.
UFL1 regulates milk protein and fat synthesis-related gene expression of bovine mammary epithelial cells probably via the mTOR signaling pathway.
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice.
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer.
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice.
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.
Compound C enhances the anticancer effect of aspirin in HER-2-positive breast cancer by regulating lipid metabolism in an AMPK-independent pathway.
Delivery of microRNA-33 Antagomirs by Mesoporous Silica Nanoparticles to Ameliorate Lipid Metabolic Disorders.
Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer.
SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β-catenin signaling pathway.
Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress.
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy.
Viburnum opulus L. Juice Phenolics Inhibit Mouse 3T3-L1 Cells Adipogenesis and Pancreatic Lipase Activity.
Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes.
Sesamol Alleviates Obesity-Related Hepatic Steatosis via Activating Hepatic PKA Pathway.
A metastasis map of human cancer cell lines.
ZHX2 inhibits SREBP1c-mediated de novo lipogenesis in hepatocellular carcinoma via miR-24-3p.
Exosomal miR-199a-5p promotes hepatic lipid accumulation by modulating MST1 expression and fatty acid metabolism.
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
GRP78 regulates milk biosynthesis and the proliferation of bovinemammaryepithelial cells through the mTOR signaling pathway.
MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway.
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
NUCKS1 is a novel regulator of milk synthesis in and proliferation of mammary epithelial cells via the mTOR signaling pathway.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.
Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes.
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
U2AF65 enhances milk synthesis and growth of bovine mammary epithelial cells by positively regulating the mTOR-SREBP-1c signalling pathway.
Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha.
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells.
microRNA-16-5p promotes 3T3-L1 adipocyte differentiation through regulating EPT1.
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Fibronectin type III domain-containing protein 5 promotes proliferation and differentiation of goat adipose-derived stem cells.
Cyclase-associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells.
Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor α Activation.
Downregulation of microRNA-1 attenuates glucose-induced apoptosis by regulating the liver X receptor α in cardiomyocytes.
NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression.
CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.
Mitochondrial ATAD3A regulates milk biosynthesis and proliferation of mammary epithelial cells from dairy cow via the mTOR pathway.
Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway.
MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study.
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.
DEAD-box helicase 6 (DDX6) is a new negative regulator for milk synthesis and proliferation of bovine mammary epithelial cells.
Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice.
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis.
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout.
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Chronic dexamethasone exposure markedly decreased the hepatic triglyceride accumulation in growing goats.
Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway.
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.
Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner.
Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis.
Sodium sulfite promotes the assembly and secretion of very low-density lipoprotein in HL-7702 hepatocytes.
Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice.
MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling.
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer.
Supplementation of chitosan alleviates high-fat diet-enhanced lipogenesis in rats via adenosine monophosphate (AMP)-activated protein kinase activation and inhibition of lipogenesis-associated genes.
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction.
LXRalpha gene downregulation by lentiviral-based RNA interference enhances liver function after fatty liver transplantation in rats.
Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.
Pleiotropic effects of cavin-1 deficiency on lipid metabolism.
A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62.
Yan Y, Li C, Zhang J, Li R, Yin B, Zhang S, Zhang Y, Zhang X, Han J, Huang J
International journal of biological sciences 2026;22(3):1590-1610
International journal of biological sciences 2026;22(3):1590-1610
Identification of the Antioxidant Enzyme B166 as a Novel Biomarker for Patients With Glioblastoma Multiforme.
Liu W, Wang B, Kong F, Cheung C
Analytical cellular pathology (Amsterdam) 2026;2026(1):e6120748
Analytical cellular pathology (Amsterdam) 2026;2026(1):e6120748
Gut-Derived Hippuric Acid Alleviates Hepatic Lipid Metabolism via UGDH/FOXK1/CD36 Axis in Obese Mice.
Chen S, Xue J, Shao Y, Liu H, Zhou F, Gu X, Zhou G, Xu T, Wang D, Tang L
Drug design, development and therapy 2026;20:595588
Drug design, development and therapy 2026;20:595588
Intermittent fasting ameliorates MAFLD by downregulating Lrg1: insights from bulk RNA sequencing and functional verification.
Chen H, Zhang S, Xie W, Shen J, Liang H
Frontiers in endocrinology 2026;17:1754251
Frontiers in endocrinology 2026;17:1754251
Iron overload reprogramming lipid metabolism through the IRP1-SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis.
Liu Y, Fang L, Wang M, Zhong S, Xiong Y, Hou Y, Ren J, Li Y, Zhu W, Meng X, Lu C, Pan Y
Experimental & molecular medicine 2026 May 1;
Experimental & molecular medicine 2026 May 1;
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Wang J, Liu WW, Huang QL, Ning HJ, Wang JY, Han XH
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Integrated Proteomics and Metabolomics Reveal the Direct Hepatic Protection of Propionate Against Alcoholic Liver Disease via the RGN-PPARα Pathway.
Wang H, Liu H, Wang M, Chi T, Liu F, Qu X, Mu Y, Xu Q, Wang Q
Nutrients 2026 Mar 9;18(5)
Nutrients 2026 Mar 9;18(5)
TFAP2A regulates SGPP2 transcription to promote lipid accumulation and activate the Wnt/β-catenin signaling pathway to promote malignant progression in lung adenocarcinoma.
Li Q, Li J, Zhang C, Deng Y, Yang B, Ma L, Liu Y, Wang C, Xu L, Mei J
Journal of translational medicine 2026 Mar 4;24(1)
Journal of translational medicine 2026 Mar 4;24(1)
Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes.
Chen L, Kang Z, Härdfeldt J, Li Z, Pedrelli M, Li Q, Lyu R, Valina Allo P, Sych T, Zheng X, Lin P, Zeng J, Huang Z, Garcia-Irigoyen O, Sukhanava S, Parini P, Bonnefond A, Sezgin E, Angelin B, Treuter E, Fan R
Nature communications 2026 Mar 23;17(1)
Nature communications 2026 Mar 23;17(1)
METTL1-deficient mesenchymal stem cells protect against metabolic-associated fatty liver disease by increasing NAMPT secretion.
Du J, Zhang Y, Wang C, Wang Y, Zhang H, Zhao D, Lin J
Stem cells translational medicine 2026 Mar 23;15(4)
Stem cells translational medicine 2026 Mar 23;15(4)
Chemerin Promotes Oral Squamous Cell Carcinoma Progression via NLRP3-Mediated Pyroptosis and the GSDMD-N Pathway.
Zhang X, Guo Y, Gao F, Ni X, Li T, Wang C, Lin M, Tan X, Wang N, Feng Y
International dental journal 2026 Jun;76(3):109541
International dental journal 2026 Jun;76(3):109541
Momordin Ic targets SREBP1 to disrupt lipid homeostasis and trigger synergistic apoptosis-ferroptosis in triple-negative breast cancer.
Cheng Y, Shi YZ, Zheng JY, Liu YB, Chen YT, Bao JX, He XY, Chen JQ, Li Q, Dai XX
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158190
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158190
Farrerol ameliorates hepatic insulin resistance via AMPKα1/mTOR/SREBP-1 pathway: A study in T2DM rat models and palmitic acid-induced BRL 3 A hepatocytes.
Li Y, Feng X, Zheng L
Tissue & cell 2026 Jun;100:103367
Tissue & cell 2026 Jun;100:103367
Multi-omics integration reveals the ameliorative effects and underlying mechanisms of Astragalus membranaceus (Huangqi)-Fuzhuan brick tea on nonalcoholic fatty liver disease.
Chen T, Yang S, Zhang X, Chen J, Yang X, Li C, Yang M, Li J, Ji X, Yan S
Journal of ethnopharmacology 2026 Jul 15;366:121616
Journal of ethnopharmacology 2026 Jul 15;366:121616
Integrating IDEAL-IQ Sequence with Mass Spectrometry Imaging for Profiling Lipid-Related Metabolic Reprogramming of Acute Kidney Injury.
Zhao H, Chen Y, Guan B, Li J, Xu C, Guo J, Zhang L, Sun J, Zhao H, Zhang R
Small methods 2026 Jan;10(1):e01704
Small methods 2026 Jan;10(1):e01704
Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling.
Chen C, Ma L, Dawuti A, Feng X, Chen S, An X, Bai Y, Zhang T, Aydin M, Kashmiri K, Ma Z, Zhang W, Yaermaimaiti S, Abulizi A
NPJ science of food 2026 Jan 23;10(1):73
NPJ science of food 2026 Jan 23;10(1):73
The YAP/SCAP/SREBP1 pathway in astrocytes: A novel target for treating neonatal hypoxic-ischemic encephalopathy.
Wang J, Dai C, Yuan H, Tian Q, Xiao Q, Li X, Shi X, Dong Z
Progress in neurobiology 2026 Feb;257:102869
Progress in neurobiology 2026 Feb;257:102869
Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development.
Tong J, Wang D, Song H, Sun T, Zhao Y, Gu W, Lin L, Zhao Y, Liang Y, Jin X, Fu R, Ju M, Gao J, Ma J, Gao C, Zhang A, Xiao Z, Jiang E, Yang R, Ma S, Zhang L, Shi L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e05249
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(7):e05249
KDM5B cooperates with CRL4B complex to promote the tumorigenesis of ER+ breast cancer via regulating cholesterol metabolism.
Yang Y, Gao T, Yuan B, Hao X, Huo M, Hu T, Ma T, Zhang M, Zhang D, Teng X, Yu H, Huang W, Zhang J, Wang Y
Cell death & disease 2026 Feb 7;17(1):207
Cell death & disease 2026 Feb 7;17(1):207
Paeoniflorin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease by Inhibiting Hepatic Lipogenesis and Inflammation.
Wei SZ, Dong Y, Zhou HY, Yang J, Lu JF, Zhao YL, Zhao Y, Lu JF
Inflammation 2026 Feb 26;49(1)
Inflammation 2026 Feb 26;49(1)
Macrophage-derived IL-6 reprograms lipid metabolism to promote colorectal cancer development through USP14-mediated FASN deubiquitination.
Yunxin L, Xirui X, Xinyi Z, Chenjing W, Ting Z, Kanghui F, Haixia Y, Zude C, Wan H, Yubing Z, Xianjun F
Journal of translational medicine 2026 Feb 26;24(1)
Journal of translational medicine 2026 Feb 26;24(1)
FOXN3 integrates the KU70/KU80/SREBP-1 complex to regulate lipid metabolism in non-alcoholic fatty liver disease.
Du J, Jin L, Wang S, Hu X, Yu J, Yu J, Huo Q, Wu N, Liu X, Yang Y, Zhang Y, Huang S, Zhou J, Zheng SG, Zheng C, Zhu X
Nucleic acids research 2026 Feb 24;54(5)
Nucleic acids research 2026 Feb 24;54(5)
lncRNA MALAT1-mediated regulation of cholesterol-oxidative stress-iron metabolic dysregulation by paeoniflorin in osteoarthritic chondrocytes.
Fu C, Lan S, Lin Y, Chen D, Yang Z, Chen C, Chen Y, Yuan Y, Zhong W, Lin Q, Huang Z
Pharmaceutical biology 2026 Dec;64(1):278-294
Pharmaceutical biology 2026 Dec;64(1):278-294
Baicalein alleviates hepatic lipid metabolism disorders via the PPARα-FGF21-adiponectin axis: Regulating crosstalk between the liver and adipose tissue.
Xia QS, Chen Y, Shen P, Gong J, Lu FE, Chen H
Journal of ethnopharmacology 2026 Aug 10;367:121676
Journal of ethnopharmacology 2026 Aug 10;367:121676
FTO mediates m6A demethylation of HNF1A and drives hepatic steatosis in metabolic dysfunction-associated steatotic liver disease.
Tan J, Shi C, Wang G, Zhang L, Li F, Yan G, Jin Y, Ding H, Jiang F, Li X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Apr;1871(3):159732
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Apr;1871(3):159732
Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy.
Zhao Y, Liu M, Zang X, Li J, Zhang G, Du P, Zhang T, Sun X, Li C, Liu L
Food research international (Ottawa, Ont.) 2026 Apr 1;229:118355
Food research international (Ottawa, Ont.) 2026 Apr 1;229:118355
Rabdosia rubescens Inhibits CYP7A1 Expression and Induces Autophagy to Reduce Alcohol-Induced Liver Damage in Mice.
Zou X, Chen W, Shao Y, Shi T, Ke Y
Canadian journal of gastroenterology & hepatology 2025;2025:9507266
Canadian journal of gastroenterology & hepatology 2025;2025:9507266
Unraveling SREBF1's role in elevating colorectal cancer prognosis through proliferation and migration inhibition.
Li D, Cai Q, Xu F, Lin L, Zhou X, Li L, Chen Y, Feng T, Gan Y, Zhang C, Yang F
PloS one 2025;20(7):e0327503
PloS one 2025;20(7):e0327503
Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy.
Lei S, Wu Q, Zhang B, Lu M, Xia Y, Li N
International journal of nanomedicine 2025;20:5017-5037
International journal of nanomedicine 2025;20:5017-5037
An integrative pharmacology-based study on the pharmacological activity and mechanism of xiaoji-chenpi formula (XCF) against MAFLD.
Liang S, Dong Y, Chang Z, Guo P, Jia J, Yang G, Chen Y, Dong L, Xu X, Cai T, Li T, Fang Y, Sun W, Li L, Wang C, Song X
Frontiers in pharmacology 2025;16:1521111
Frontiers in pharmacology 2025;16:1521111
Brexpiprazole inhibits EMT and migration of colorectal cancer cells by downregulating the SREBP1/SNAI1 signaling pathway.
Liu X, He J, Ma A, Xia W, Xia Z, Liu L, Wu Z, Chen W
Frontiers in oncology 2025;15:1734678
Frontiers in oncology 2025;15:1734678
Reduction in within-litter variation of piglet birth weight through dietary supplementation of 3-hydroxyisobutyric acid in sows.
Che L, Niu L, Liu L, Li M, Huo W, Deng H, Chen W, Pang L, Xu M
Frontiers in veterinary science 2025;12:1646332
Frontiers in veterinary science 2025;12:1646332
Insights Into the Mechanism of Action for Qingzhi Decoction for the Treatment of Non-Alcoholic Fatty Liver Disease via Regulation of the IRS/PI3K/Akt Signaling Pathway and the NRLP3 Inflammasome.
Yan J, Hou Q, Liu J, Li W
Biomedical chromatography : BMC 2025 Sep;39(9):e70156
Biomedical chromatography : BMC 2025 Sep;39(9):e70156
NDRG2 regulates milkfatbiosynthesis by targeting the AMPK/SREBP1 axis in bovine mammary epithelial cells.
Cheng J, Wang L, Li L, Kuang T, Su H, Ren K, Pan S
International journal of biological macromolecules 2025 Sep;321(Pt 4):146448
International journal of biological macromolecules 2025 Sep;321(Pt 4):146448
CHAF1A Promotes Preadipocyte Differentiation and Contributes to Macrosomia in Gestational Diabetes Mellitus.
Xia D, Xu X, Zhang Y, Zhang C, Wang H
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):3086-3102
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):3086-3102
Cigarette smoke-induced PPAR signaling dysregulation accelerates Alzheimer's disease pathogenesis and cognitive decline in 5xFAD mice.
Xie Y, Wang H, Zhang Y, Lin B, Chen Y, Li K, Tang H, Sun Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115596
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115596
Choline reduces inflammatory response and lipid accumulation in calf hepatocytes induced by NEFA via inhibiting ROS/ NF-κB/NLRP3 inflammasome axis.
Zhang R, Du X, Hu H, Chen J, Yu J, Wang L, Yao J, Liu S, Wang J, Cao Y
Molecular immunology 2025 Sep;185:116-126
Molecular immunology 2025 Sep;185:116-126
The 5-Aminolevulinic Acid Photodynamic Therapy Modulates Lipid Production by Protein Kinase B/JunD-Mediated NR4A1 Activation in the Treatment of Acne Vulgaris.
Wu Y, Liu X, Zhang L, Wang P, Zhang H, Yan J, Yan Y, Liu P, Zhao J, Zeng Q, Wang X
The Journal of investigative dermatology 2025 Sep;145(9):2179-2190.e2
The Journal of investigative dermatology 2025 Sep;145(9):2179-2190.e2
SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1-Mediated Transactivation of CD47.
Liu Z, Zhao X, Zang M, Yuan H, Qin X, Li X, Zhao S, Tan R, Yan K, Liu L, Fan Y, Zhang N, Shi B, Han B, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e04200
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e04200
Betaine decreases hepatic lipid deposition through DNA 5 mC and RNA m(6)A methylation-mediated regulation of fatty acid metabolic genes expression in laying hens.
Yang Y, Jin X, Lu D, Wu Y, Meng F, Zhang M, Wang J, Cui X, Li T, Wang S, Luo X, Hu Y
Poultry science 2025 Sep;104(9):105496
Poultry science 2025 Sep;104(9):105496
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Mastitis via NCOA4-Mediated Ferritinophagy.
Mao P, Wang Z, Duan J, Dong P, Yuan C, Liu K, Guo L, Cui L, Dong J, Meng X, Zhu G, Li J, Wang H
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24326-24342
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24326-24342
Saponin from Tea (Camellia sinensis) Seed Meal Attenuates Cortisol-Induced Lipogenesis and Inflammation in Human Cells.
Li J, Zhang LY, Huang YC, Deng JM, Yu M, Zouboulis CC, Li JH, Wang GL, Wang J
Molecules (Basel, Switzerland) 2025 Sep 23;30(19)
Molecules (Basel, Switzerland) 2025 Sep 23;30(19)
Breviscapine regulates lipid metabolism of microglia via the ADORA1/PPARα/ACOX1 pathway to promote spinal cord injury recovery.
Shi F, Wang S, Wu C, Wen H, Zhou W
International immunopharmacology 2025 Sep 23;162:115145
International immunopharmacology 2025 Sep 23;162:115145
Enhanced bioactivity of honeysuckle-Cassia seeds extracts through Lactobacillus acidophilus and Bacillus subtilis co-fermentation: Impact on alcoholic liver disease and gut microbiota.
Zhou M, Zhang Y, Song Z, Tang S, Liu Z, Pang M, Zhang D, Wu X, Yu X, Wang P, Wei Y
Food chemistry 2025 Sep 15;486:144463
Food chemistry 2025 Sep 15;486:144463
SLC25A40 promotes NSCLC growth by enhancing NADPH-mediated lipid synthesis and suppressing ROS accumulation-induced ferroptosis.
Xue P, Guo X, Zhang B, Yang X, Gao J, Zhou F, Ma J, Jin F
Experimental cell research 2025 Sep 1;452(1):114727
Experimental cell research 2025 Sep 1;452(1):114727
Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway.
Chen Q, Lin H, Huang X, Yu W
Tissue & cell 2025 Oct;96:102984
Tissue & cell 2025 Oct;96:102984
Androgen regulates seasonal changes in triglyceride synthesis through the AR-SREBP1-FASN axis in the scented glands of muskrats (Ondatra zibethicus).
Shi X, Gao Q, Lu W, Xie Y, Zhang H, Zhang D, Liu Y, Weng Q
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159675
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Oct;1870(7):159675
Network pharmacology and transcriptomics reveal complanatoside A regulates lipid metabolism in hyperlipidemia and nonalcoholic fatty liver disease via the AMPK pathway.
Jiang S, Liang Z, Hua J, Li Y, Fan X, Qiao Z, Wang Z, Shen Y, Fan L, Wang J
The Journal of nutritional biochemistry 2025 Oct;144:109960
The Journal of nutritional biochemistry 2025 Oct;144:109960
RUNX2 cooperates with SREBP1 to rewire cancer metabolism and promote aggressiveness.
Vitale E, Gugnoni M, Manicardi V, Muccioli S, Torricelli F, Donati B, Piana S, Manzotti G, Salviato E, Reggiani F, Ascione C, Vezzani R, Ragazzi M, Forcato M, Romano O, Bicciato S, Goldman AR, Tigano M, Ciarrocchi A
Journal of experimental & clinical cancer research : CR 2025 Oct 31;44(1):298
Journal of experimental & clinical cancer research : CR 2025 Oct 31;44(1):298
Imidacloprid contributes to bladder cancer progression: preliminary evidence based on network toxicology, machine learning and molecular docking.
Ming J, Jin S, Liu Z, Yang K, Shi M, Niu Y
BMC pharmacology & toxicology 2025 Oct 30;26(1):180
BMC pharmacology & toxicology 2025 Oct 30;26(1):180
Growth hormone excess drives liver aging via increased glycation stress.
Singh P, Gautam A, Trujillo MN, Singh P, Najera LE, Galligan JJ, Hensley L, Kapahi P, Bartke A
Aging 2025 Oct 3;17(10):2534-2551
Aging 2025 Oct 3;17(10):2534-2551
Collagen peptides from Skipjack tuna (Katsuwonus pelamis) bones: Composition, characterization, and mechanism of high-fat diet-induced NAFLD amelioration.
Jiang YL, Zhang SY, Wang B, Zeng YH, Xu L, Chi CF
Food research international (Ottawa, Ont.) 2025 Nov;219:117114
Food research international (Ottawa, Ont.) 2025 Nov;219:117114
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
Rattani A, Anderson C, Trim WV, Garita E, Imada S, Khawaled S, Shin H, Zhang J, Yilmaz ÖH, Kirschner M
bioRxiv : the preprint server for biology 2025 Nov 18;
bioRxiv : the preprint server for biology 2025 Nov 18;
Genome-Wide Network Analysis of DRG-Sciatic Nerve Network-Inferred Cellular Senescence and Senescence Phenotype in Peripheral Sensory Neurons.
Kawabata S, Iijima H, Kanemura N, Murata K
Molecular neurobiology 2025 May;62(5):6112-6127
Molecular neurobiology 2025 May;62(5):6112-6127
FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism.
Chang K, Hong F, Liu H, Fang Y, Wang H, Song N, Ning Y, Lu Z, Jin S, Dai Y, Ding X
Biochemical pharmacology 2025 May;235:116819
Biochemical pharmacology 2025 May;235:116819
Steam explosion modified pea peptides alleviates hepatosteatosis by regulating lipid metabolism pathways and promoting autophagy.
Zhang J, Song L, Li T, Zhu L, Wang T, Zhao P, Ma Y, Zhao J, Huang X
Food research international (Ottawa, Ont.) 2025 May;208:116182
Food research international (Ottawa, Ont.) 2025 May;208:116182
A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes.
Chen M, Peng Y, Hu Y, Kang Z, Chen T, Zhang Y, Chen X, Li Q, Yuan Z, Wu Y, Xu H, Zhou G, Liu T, Zhou H, Yuan C, Huang W, Zhang W
Acta pharmaceutica Sinica. B 2025 May;15(5):2511-2528
Acta pharmaceutica Sinica. B 2025 May;15(5):2511-2528
Alkannin triggered apoptosis and ferroptosis in gastric cancer by suppressing lipid metabolism mediated by the c-Fos/SREBF1 axis.
Yu H, Kou Q, Yuan H, Qi Y, Li Q, Li L, Zhao G, Wang G, Li S, Qu J, Chen H, Zhao M, Wang Q, Li S, Chen K, Lu C, Xiao H, Lin P, Li K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156604
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156604
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
Su J, Fan X, Zou Y, Fu G, Feng S, Wang X, Yu Y, Li L, Bian Z, Huang R, Qin L, Chen J, Zeng Q, Yan K, Gao C, Lian Z, Li X, Li Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2409154
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2409154
The Splice Variant of the NCOR2 Gene BQ323636.1 Modulates ACSL4 Expression to Enhance Fatty Acid Metabolism and Support of Tumor Growth in Breast Cancer.
Tsoi H, You CP, Cheung KH, Tse YS, Khoo US
International journal of molecular sciences 2025 May 22;26(11)
International journal of molecular sciences 2025 May 22;26(11)
Hepatic HSD17B6 is dispensable for diet-induced fatty liver disease in mice.
Yuan D, Bai N, Zhu Q, Song S, He A, Wang J, Chen Y
Biochemistry and biophysics reports 2025 Mar;41:101924
Biochemistry and biophysics reports 2025 Mar;41:101924
The effects of citalopram and sertraline on adipogenesis and lipogenesis in 3T3-L1 cells.
Bozdag D, Entezari B, Gurer-Orhan H
Toxicology letters 2025 Mar;405:67-75
Toxicology letters 2025 Mar;405:67-75
RORα fine-tunes the circadian control of hepatic triglyceride synthesis and gluconeogenesis.
Monnier C, Ganbold M, Auclair M, Roblot N, Boutin AB, Boutin PK, Fève B, Antoine B
Scientific reports 2025 Mar 26;15(1):10464
Scientific reports 2025 Mar 26;15(1):10464
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation.
Yang G, Ma C, Chen Y, Xiang J, Li L, Li Y, Kang L, Liang Z, Yang S
Cell reports 2025 Mar 25;44(3):115339
Cell reports 2025 Mar 25;44(3):115339
Structure characteristics of a novel pectic polysaccharide from Fructus Corni and its protective effect on alcoholic fatty liver.
Bai HX, Gao YX, Wang S, Ma GY, Zhao W, Li XQ, Wang YF, Nong QN, Wang YB, Tan J, Duan Q, Cao W
Carbohydrate polymers 2025 Mar 15;352:123153
Carbohydrate polymers 2025 Mar 15;352:123153
NCOA6 knockdown enhances RSL3-induced ferroptosis in pancreatic cancer cells and increases the sensitivity to gemcitabine.
Jia Y, Ye Z, Wang X, Deng Y, Wang C, Zhang Z, Fan G, Yang W, Xu X, Qin Y, Peng L
Acta biochimica et biophysica Sinica 2025 Mar 10;57(8):1260-1269
Acta biochimica et biophysica Sinica 2025 Mar 10;57(8):1260-1269
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Fu X, Zhang Q, Chen Y, Li Y, Wang H
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
Xie E, Wang Q, Yi H, Wang J, Liu X, Ye R, Lu L, Tian T, Chen A, Zheng G, Zhang G, Wang H
International journal of biological macromolecules 2025 Jun;312:144097
International journal of biological macromolecules 2025 Jun;312:144097
CD36 molecule and AMP-activated protein kinase signaling drive docosahexaenoic acid-induced lipid remodeling in goat mammary epithelial cells.
Wu J, Luo J, He Q, Zhang F, Shi C, Zhao J, Li C, Deng W
International journal of biological macromolecules 2025 Jun;311(Pt 4):144076
International journal of biological macromolecules 2025 Jun;311(Pt 4):144076
Linghe granules reduces hepatic lipid accumulation in Non-alcoholic fatty liver disease through regulating lipid metabolism and redox balance.
Hu Y, Li N, Zhang R, Wang J, Fang D, Zhou Q, Zhang H, Cai H, Lu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156654
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156654
Hawthorn total flavonoids ameliorate hyperlipidemia through AMPK/SREBP1-c and PPARα/PGC-1α/CPT-1A pathway activation and gut microbiota modulation.
Zheng L, Lu Z, Ma Y, Cui P, Zhang X, Gan J, Li G
Journal of the science of food and agriculture 2025 Jun;105(8):4326-4337
Journal of the science of food and agriculture 2025 Jun;105(8):4326-4337
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
Ying W, Weng W, Wang P, Pan C, Qiu J, Huang Q, Zhan G, Chen X
Journal of neuroinflammation 2025 Jun 27;22(1):167
Journal of neuroinflammation 2025 Jun 27;22(1):167
Effects of Long-Term Blue Light Exposure on Body Fat Synthesis and Body Weight Gain in Mice and the Inhibitory Effect of Tranexamic Acid.
Hiramoto K, Oikawa H
International journal of molecular sciences 2025 Jun 10;26(12)
International journal of molecular sciences 2025 Jun 10;26(12)
Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function.
Li Y, Wu R, Li X, Li J, Zhang Y, Huang Y, Fan G, Li X
Chinese herbal medicines 2025 Jul;17(3):488-499
Chinese herbal medicines 2025 Jul;17(3):488-499
KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy.
Guo J, Li N, Liu Q, Hao Z, Zhu G, Wang X, Wang H, Pan Q, Xu B, Han Y, Zhang G, Lian Y, Zhang W, Gu Y, Lin N, Zeng X, Jin Z, Lan W, Jiang J, Gao D, Dong L, Yuan H, Liang C, Qin J
Cancer cell 2025 Jul 14;43(7):1261-1278.e10
Cancer cell 2025 Jul 14;43(7):1261-1278.e10
Multiomics analysis revealed the regulatory role of chenodeoxycholic acid in fatty acid metabolism and lipid homeostasis.
Li L, Ren X, Gao X, Zhao Y, Ma Y, Gong J, Yang S, Sun Y, Wang Y
Lipids in health and disease 2025 Jul 14;24(1):238
Lipids in health and disease 2025 Jul 14;24(1):238
Foxk2 Enhances Adipogenic Differentiation by Relying on the Transcriptional Activation of Peroxisome Proliferator-Activated Receptor Gamma.
Zhang S, You Y, Li R, Li M, Li Y, Yuan H, Zhou J, Zhen R, Liu Y, Wang B, Zhu E
Journal of cellular and molecular medicine 2025 Jan;29(1):e70332
Journal of cellular and molecular medicine 2025 Jan;29(1):e70332
Acute heat stress regulates estradiol synthesis in ovine ovarian granulosa cells through the SREBPs/MVK-LHR pathway.
Li Y, Li F, Shu J, Meng C, Zhang J, Zhang J, Qian Y, Wang H, Ding Q, Cao S
Animal reproduction science 2025 Jan;272:107649
Animal reproduction science 2025 Jan;272:107649
Negative regulation of SREBP-1/FAS signaling molecules activates the RIG-1/TBK1-mediated IFN-I pathway to inhibit BVDV replication.
Liu S, Luo A, Que T, Liang Y, Song Y, Liu T, Li J, Li N, Zhang Z, Liu Y, Zhang Z, Zhou Y, Wang X, Zhu Z
Antiviral research 2025 Jan;233:106054
Antiviral research 2025 Jan;233:106054
Bisphenol S Induces Lipid Metabolism Disorders in HepG2 and SK-Hep-1 Cells via Oxidative Stress.
Lin KX, Wu ZY, Qin ML, Zeng HC
Toxics 2025 Jan 8;13(1)
Toxics 2025 Jan 8;13(1)
Floralozone attenuates atherosclerotic vascular injury by regulating AMPKα/SREBP-1c pathway and down-regulating miR-33-5p.
Guo YQ, Zhao HL, Zhao JM, Li SS, Meng LW, Li J, Qian YW, Li YL, Cui BY, Guo S, Li P, Li CZ
European journal of nutrition 2025 Jan 7;64(1):65
European journal of nutrition 2025 Jan 7;64(1):65
Klebsiella pneumoniae causes mammary gland damage via FNIP1-mediated mitochondrial dysfunction.
Dong P, Yuan C, Wang Z, Mao P, Liu K, Li J, Dong J, Cui L, Guo L, Meng X, Zhu G, Liu H, Wang R, Zhang L, Wang H
Journal of animal science 2025 Jan 4;103
Journal of animal science 2025 Jan 4;103
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Ren X, Zhou N, Li D, Li L, Wang Y, Li L, Ma Y, Gao X, Zhao Y, Sun Y, Wang Y
Journal of ethnopharmacology 2025 Jan 31;340:119278
Journal of ethnopharmacology 2025 Jan 31;340:119278
Fatty Acid Esterification of Octacosanol Attenuates Triglyceride and Cholesterol Synthesis in Mice.
Kamchonemenukool S, Koh YC, Ho PY, Pan MH, Weerawatanakorn M
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442
Journal of agricultural and food chemistry 2025 Jan 29;73(4):2430-2442
DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway.
Wang H, Luo S, Yin Y, Liu Y, Sun X, Qiu L, Wu X
Cancer cell international 2025 Jan 27;25(1):25
Cancer cell international 2025 Jan 27;25(1):25
Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping.
Huang S, Wang H, Cao J, Pang Q
Scientific reports 2025 Jan 18;15(1):2394
Scientific reports 2025 Jan 18;15(1):2394
Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9.
Zhou C, Feng Z, Qian W, Zhu Z, Cao R, Wang Q, Zhang W, Liu R, Wu S, Hao J, Wang Z, Ma Q, Wu Z, Li X
Biology direct 2025 Jan 14;20(1):6
Biology direct 2025 Jan 14;20(1):6
Identification of Novel 58-5p and SREBF1 Interaction and Effects on Apoptosis of Ovine Ovarian Granulosa Cell.
Yang R, Wang Y, Yue S, Liu Y, Zhang Y, Duan C
International journal of molecular sciences 2025 Jan 11;26(2)
International journal of molecular sciences 2025 Jan 11;26(2)
Melittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism.
Wu R, Li N, Huang W, Yang Y, Zang R, Song H, Shi J, Zhu S, Liu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156367
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156367
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
Xin W, Zhou J, Peng Y, Gong S, Liao W, Wang Y, Huang X, Mao Y, Yao M, Qin S, Xiong J, Li Y, Lan Q, Huang Y, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
Rno-miR-130b Attenuates Lipid Accumulation Through Promoting Apoptosis and Inhibiting Differentiation in Rat Intramuscular Adipocytes.
Yu Y, Chen Y, Wang L, Cheng J, Du M, Pan S
International journal of molecular sciences 2025 Feb 7;26(4)
International journal of molecular sciences 2025 Feb 7;26(4)
Mechanism of O-GlcNAcylation regulating liver lipid synthesis in mice through FASN.
Li X, Zhang Z, Zhang M, Cao Y, Zhou W, Kou L, Guo W, Zhang B, Li S, Xu B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 28;39(4):e70359
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Feb 28;39(4):e70359
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling.
Ding K, Zhang Z, Han Z, Shi L, Li X, Liu Y, Li Z, Zhao C, Cui Y, Zhou L, Xu B, Zhou W, Zhao Y, Wang Z, Huang H, Xie L, Chen XW, Chen Z
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Science (New York, N.Y.) 2025 Feb 28;387(6737):eadp4120
Energy Stress-Induced circEPB41(2) Promotes Lipogenesis in Hepatocellular Carcinoma.
Yang Y, Luo J, Wang Z, Liu K, Feng K, Wang F, Mei Y
Cancer research 2025 Feb 17;85(4):723-738
Cancer research 2025 Feb 17;85(4):723-738
Transcriptome Reveals the Promoting Effect of Beta-Sitosterol on the Differentiation of Bovine Preadipocytes.
Jiang L, Sun X, Wan Y, Qin Q, Xu M, Ma J, Zan L, Wang H
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3400-3412
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3400-3412
Cepharanthine relieves nonalcoholic steatohepatitis through inhibiting STAT1/CXCL10 axis-mediated lipogenesis and inflammatory responses.
Li P, Zhang R, Hu P, Wang T, Wang J
Journal of ethnopharmacology 2025 Feb 11;341:119358
Journal of ethnopharmacology 2025 Feb 11;341:119358
Perilipin1 mediates milk fat synthesis in bovine mammary epithelial cells through SREBP1 phosphorylation.
Yang B, Wang M, Wu Z, Tan J, Meng Y, Zhang T, Zan L, Yang W
Animal biotechnology 2025 Dec;36(1):2497915
Animal biotechnology 2025 Dec;36(1):2497915
Glyoxalase 1 is a proadipogenic gene.
Trujillo MN, Zhang WC, Hoffman EA, Kitamura N, Phoebe AM, Galligan JJ
The Journal of biological chemistry 2025 Dec;301(12):110926
The Journal of biological chemistry 2025 Dec;301(12):110926
Tryptophan derivatives as non-invasive diagnostic indicators for obesity-related MASLD in children and adolescents.
Zhan S, Wang X, Wang C, Zhu B, Gao J, Peng Z, Wang R, Yang Y, Zhang L, Wang T, Wu J, Wu W, Huang K, Dong G, Ren Q, Wang S, Wang S, Zhou X, Xu L, Fu J, Guo X
Diabetes, obesity & metabolism 2025 Dec;27(12):7544-7560
Diabetes, obesity & metabolism 2025 Dec;27(12):7544-7560
Triterpenoid saponins from Ilex latifolia inhibit breast cancer growth by disrupting the SREBP1/FASN-mediated lipid metabolic pathway.
Wang F, Wang M, Shi Z, Wu Y, Wang C, Wang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Dec;193:118793
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Dec;193:118793
Leukocyte immunoglobulin-like receptor B2 regulates atherosclerosis progression by modulating macrophage extracellular trap formation in foam macrophages through the PI3K-AKT signaling pathway.
Jiao Y, Hu R, Gui L, Miu S, Zhang X, Zou J
Journal of cell communication and signaling 2025 Dec;19(4):e70053
Journal of cell communication and signaling 2025 Dec;19(4):e70053
Gut-liver axis mechanisms of Hippophae rhamnoides L. in non-alcoholic fatty liver disease prevention.
Ma J, Li Y, Yang Y, Zhao L, Jiang Y, Wong TW, Zhang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157517
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Dec;149:157517
An ATF3 Inducer Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease Through the AMPK and PKA Pathways.
Cheng CF, Yang RB, Chen WT, Chung JF, Ku HC
International journal of molecular sciences 2025 Dec 9;26(24)
International journal of molecular sciences 2025 Dec 9;26(24)
Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer.
Chen J, Cui H, Wang X, Zeng Y, Pan D, Chen J, Zhang Z, An Y, Gu Z, Cai G, Wang H, Yu M, Yang B, Zhou S, Tan J, Liu L, Wang J, Li J, Han F
Journal of translational medicine 2025 Dec 9;23(1):1390
Journal of translational medicine 2025 Dec 9;23(1):1390
The protein denitrosylase SCoR2 regulates lipogenesis and fat storage.
Venetos NM, Stomberski CT, Zhou HL, Qian Z, McLaughlin PJ, Bansal PK, Feczko J, Bederman I, Nguyen H, Hausladen A, Schindler JC, Grimmett ZW, Brunengraber H, Premont RT, Stamler JS
Science signaling 2025 Dec 23;18(918):eadv0660
Science signaling 2025 Dec 23;18(918):eadv0660
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.
Huang G, Cai Y, Ren M, Zhang X, Fu Y, Cheng R, Wang Y, Miao M, Zhu L, Yan T
Journal of advanced research 2025 Aug;74:589-607
Journal of advanced research 2025 Aug;74:589-607
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma.
Zhu J, Xiong Y, Zhang Y, Liang H, Cheng K, Lu Y, Cai G, Wu Y, Fan Y, Chen X, Zhu H, Ding Z, Zhang W
Cancer communications (London, England) 2025 Aug;45(8):1038-1071
Cancer communications (London, England) 2025 Aug;45(8):1038-1071
Lipid metabolism reprograming by SREBP1-PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy.
Lao M, Zhang X, Li Z, Sun K, Yang H, Wang S, He L, Chen Y, Zhang H, Shi J, Xu D, Liang T, Bai X
Cancer communications (London, England) 2025 Aug;45(8):1010-1037
Cancer communications (London, England) 2025 Aug;45(8):1010-1037
Biomimetic membrane-coated nanoparticles for targeted synergistic therapy of homocysteine-induced atherosclerosis: Dual modulation of cholesterol efflux and reactive oxygen species scavenging.
Ding H, Liu Y, Xia T, Zhang H, Hao Y, Liu B, Jiang Y
Materials today. Bio 2025 Aug;33:101938
Materials today. Bio 2025 Aug;33:101938
Newcastle disease virus induces degradation of folliculin to regulate host cell energy metabolism and facilitate viral replication.
Yang M, Kan X, Li X, Sun Y, Liao Y, Qiu X, Tan L, Song C, Ding C
Poultry science 2025 Aug;104(8):105314
Poultry science 2025 Aug;104(8):105314
Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis.
Yu JT, Xie SS, Shen XY, Li Z, Hu XW, Zhang Y, Dong ZH, Wang JN, Li XY, Dong YH, Li C, Ji ML, Suo XG, Yang C, Jin J, Wang W, Wen JG, Liu MM, Li L, Yang Q, Meng XM
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Aug 6;33(8):3757-3777
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Aug 6;33(8):3757-3777
Helicobacter hepaticus promotes hepatic steatosis through CdtB-induced mitochondrial stress and lipid metabolism reprogramming.
Jin S, Zhu L, Bao R, Yang L, Zhuang T, Lian L, Wang T, Yin J, Zhang S, Zhou L, Zheng M, Zhang Q
Nature communications 2025 Aug 26;16(1):7954
Nature communications 2025 Aug 26;16(1):7954
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
Li J, Ma C, Cao P, Guo W, Wang P, Yang Y, Ding B, Yin F, Li Z, Wang Y, Li S, Huang C, Wang X, Zhou T, Chang A, Zhao L, Gao S, Zhao T, Wang H, Yu J, Xu J, Feng Y, Hao J
Cell reports. Medicine 2025 Aug 19;6(8):102292
Cell reports. Medicine 2025 Aug 19;6(8):102292
SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression.
Liu Z, Jiang H, Zhang Z, Jiang R, Wang R, Li J, Li W, Tan G, Fei Y, Lv Z, Guo H, Sun Z, Wu R, Shi H, Shi D
iScience 2025 Aug 15;28(8):113097
iScience 2025 Aug 15;28(8):113097
Isoliquiritigenin suppresses fatty acid synthesis and cancer cell migration in anaplastic thyroid carcinoma through AMPK/SREBF1 pathway.
Chen L, Fu Y, Wang J, Lv N, Yu S, Fang Q, Xin W
Archives of biochemistry and biophysics 2025 Apr;766:110352
Archives of biochemistry and biophysics 2025 Apr;766:110352
IRX5 Promoted SREBP1-Mediated de Novo Fatty Acid Synthesis via HMGN4 in Hepatocellular Carcinoma.
Zhu L, Xu Y, Huang C, Li C, Zhang Y, Li X, Pan W, Zeng Z
Journal of cellular and molecular medicine 2025 Apr;29(7):e70441
Journal of cellular and molecular medicine 2025 Apr;29(7):e70441
Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway.
Liu B, Yao Z, Song L, Sun C, Shen C, Cheng F, Cheng Z, Zhang R, Liu R
European journal of medicinal chemistry 2025 Apr 5;287:117379
European journal of medicinal chemistry 2025 Apr 5;287:117379
Darolutamide-mediated phospholipid remodeling induces ferroptosis through the SREBP1-FASN axis in prostate cancer.
Li B, Cheng B, Huang H, Huang S, Yu S, Li Z, Peng S, Du T, Xie R, Huang H
International journal of biological sciences 2024;20(12):4635-4653
International journal of biological sciences 2024;20(12):4635-4653
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
Wang D, Wang J, Yin Z, Gong K, Zhang S, Zha Z, Duan Y
International journal of nanomedicine 2024;19:10839-10856
International journal of nanomedicine 2024;19:10839-10856
THSR Mediated MiR374b Targeting C/EBP β/FOXO1 to Accelerate Thyroid Stimulating Hormone-Induced Hepatic Steatosis.
Li J, Ge Y, Chai Y, Kou C, Sun TT, Liu J, Zhang H
Hepatic medicine : evidence and research 2024;16:91-104
Hepatic medicine : evidence and research 2024;16:91-104
Identification of proteins related to SIS3 by iTRAQ and PRM-based comparative proteomic analysis in cisplatin-induced acute kidney injury.
Huang J, Ye J, Gao Y, Wang Y, Zhao Q, Lou T, Lai W
PeerJ 2024;12:e17485
PeerJ 2024;12:e17485
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism.
Li B, Xiao Q, Zhao H, Zhang J, Yang C, Zou Y, Zhang B, Liu J, Sun H, Liu H
Acta pharmaceutica Sinica. B 2024 Sep;14(9):3949-3963
Acta pharmaceutica Sinica. B 2024 Sep;14(9):3949-3963
Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism.
Zhou J-f, Zhang M-r, Wang Q, Li M-z, Bai J-s, Dai Q, Zhang Y-h, Yan M-x, Li X-h, Chen J, Liu Y-y, Liu C-c, Ye J, Zhou B
Journal of virology 2024 Sep 17;98(9):e0063524
Journal of virology 2024 Sep 17;98(9):e0063524
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Xing H, Wu Z, Jiang K, Yuan G, Guo Z, Yu S, He S, Zhong F
Scientific reports 2024 Sep 10;14(1):21135
Scientific reports 2024 Sep 10;14(1):21135
Dietary curcumin supplementation attenuates hepatic damage and function abnormality in a chronic corticosterone-induced stress model in broilers.
Shan X, Xu X, Wang L, Lu Y, Chen X, Li F, Du M, Xing H, Pan S
The Journal of steroid biochemistry and molecular biology 2024 Oct;243:106579
The Journal of steroid biochemistry and molecular biology 2024 Oct;243:106579
Potential Anti-Obesity Effect of Hazel Leaf Extract in Mice and Network Pharmacology of Selected Polyphenols.
Zhao J, Alimu A, Li Y, Lin Z, Li J, Wang X, Wang Y, Lv G, Lin H, Lin Z
Pharmaceuticals (Basel, Switzerland) 2024 Oct 9;17(10)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 9;17(10)
Integrated single-cell and spatial transcriptomics reveal microenvironment disruptions by androgen in mouse ovary.
Luo M, Yang X, Zhou M, Zhang J, Yu B, Lian H, Ye J
iScience 2024 Oct 18;27(10):111028
iScience 2024 Oct 18;27(10):111028
STAMBPL1, transcriptionally regulated by SREBP1, promotes malignant behaviors of hepatocellular carcinoma cells via Wnt/β-catenin signaling pathway.
Jin J, Wang Y, Hu Y
Molecular carcinogenesis 2024 Nov;63(11):2158-2173
Molecular carcinogenesis 2024 Nov;63(11):2158-2173
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E-deficient mice.
Xu MY, Xu JJ, Kang LJ, Liu ZH, Su MM, Zhao WQ, Wang ZH, Sun L, Xiao JB, Evans PC, Tian XY, Wang L, Huang Y, Liang XM, Weng JP, Xu SW
Acta pharmacologica Sinica 2024 Nov;45(11):2277-2289
Acta pharmacologica Sinica 2024 Nov;45(11):2277-2289
Polyamines mediate cellular energetics and lipid metabolism through mitochondrial respiration to facilitate virus replication.
Cruz-Pulido YE, LoMascolo NJ, May D, Hatahet J, Thomas CE, Chu AKW, Stacey SP, Villanueva Guzman MDM, Aubert G, Mounce BC
PLoS pathogens 2024 Nov;20(11):e1012711
PLoS pathogens 2024 Nov;20(11):e1012711
Macrophage-Hepatocyte Circuits Mediated by Grancalcin Aggravate the Progression of Metabolic Dysfunction Associated Steatohepatitis.
Su T, He Y, Wang M, Zhou H, Huang Y, Ye M, Guo Q, Xiao Y, Cai G, Zhao M, Wang J, Luo X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(42):e2406500
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(42):e2406500
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Huang W, Jiang M, Wang X, Pan D, Chen W, Fan L
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Journal of agricultural and food chemistry 2024 Nov 20;72(46):25601-25619
Protective Effects of Isostrictiniin Against High-Fat, High-Sugar Diet-Induced Steatosis in MASLD Mice via Regulation of the AMPK/SREBP-1c/ACC Pathway.
Yan Q, Li C, Li J, Yao Y, Zhao J
Nutrients 2024 Nov 13;16(22)
Nutrients 2024 Nov 13;16(22)
Midkine as a driver of age-related changes and increase in mammary tumorigenesis.
Yan P, Jimenez ER, Li Z, Bui T, Seehawer M, Nishida J, Foidart P, Stevens LE, Xie Y, Gomez MM, Park SY, Long HW, Polyak K
Cancer cell 2024 Nov 11;42(11):1936-1954.e9
Cancer cell 2024 Nov 11;42(11):1936-1954.e9
NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA.
Wang Z, Wan X, Khan MA, Peng L, Sun X, Yi X, Chen K
Lipids in health and disease 2024 Nov 11;23(1):368
Lipids in health and disease 2024 Nov 11;23(1):368
Histone MARylation regulates lipid metabolism in colorectal cancer by promoting IGFBP1 methylation.
Wang C, Tang Y, Zhang S, Li M, Li Q, Xiao M, Yang L, Wang Y
Experimental cell research 2024 Nov 1;443(1):114308
Experimental cell research 2024 Nov 1;443(1):114308
Toosendanin induces hepatotoxicity via disrupting LXRα/Lipin1/SREBP1 mediated lipid metabolism.
Chen S, Ni J, Luo L, Lin J, Peng H, Shen F, Huang Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114631
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114631
Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion.
Rao D, Li J, Zhang M, Huang S, Meng L, Song G, Ma J, Wu Y, Cheng Y, Ji S, Wu G, Chen L, Liu Y, Shi Y, Zhou J, Jia F, Zhang X, Xi R, Gao Q
Experimental hematology & oncology 2024 May 31;13(1):58
Experimental hematology & oncology 2024 May 31;13(1):58
Effect of LncRNA LOC106505926 on myogenesis and Lipogenesis of porcine primary cells.
Shi M, Yang S, Zhao X, Sun D, Li Y, Yang J, Li M, Cai C, Guo X, Li B, Lu C, Cao G
BMC genomics 2024 May 30;25(1):530
BMC genomics 2024 May 30;25(1):530
Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis.
Yuan Y, Xu J, Jiang Q, Yang C, Wang N, Liu X, Piao HL, Lu S, Zhang X, Han L, Liu Z, Cai J, Liu F, Chen S, Liu J
Journal of experimental & clinical cancer research : CR 2024 May 3;43(1):133
Journal of experimental & clinical cancer research : CR 2024 May 3;43(1):133
Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways.
Wang T, Zhang M, Gong X, Chen W, Peng Y, Liao C, Xu H, Li Q, Shen G, Ren H, Zhu Y, Zhang B, Mao J, Wei L, Chen Y, Yang X
iScience 2024 May 17;27(5):109741
iScience 2024 May 17;27(5):109741
Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes.
Zhu L, Shi Y, Feng Z, Yuan D, Guo S, Wang Y, Shen H, Li Y, Yan F, Wang Y
European journal of pharmacology 2024 May 15;971:176519
European journal of pharmacology 2024 May 15;971:176519
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
Zhang X, Xu Y, Li S, Qin Y, Zhu G, Zhang Q, Zhang Y, Guan F, Fan T, Liu H
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma.
Yang P, Li H, Sun M, Guo X, Liao Y, Hu M, Ye P, Liu R
Free radical biology & medicine 2024 Mar;213:512-522
Free radical biology & medicine 2024 Mar;213:512-522
RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid.
Yu Y, Xu Z, Zhou H, Xu R, Xu J, Liu W, Wu Y, Qiu Y, Zhang G, Huang X, Chen Y
Cancer cell international 2024 Mar 29;24(1):118
Cancer cell international 2024 Mar 29;24(1):118
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Li J, Ma Z, Yang Z, Yang M, Li C, Li M, Li X, Chen X, Ma H, Chen W, Ye X, Li X
Journal of ethnopharmacology 2024 Mar 25;322:117600
Journal of ethnopharmacology 2024 Mar 25;322:117600
SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis.
Wang Y, Zhao Z, Guo T, Wu T, Zhang M, Luo D, Dou K, Yang Y, Jin C, Zhang B, Zhang B, Han B
NPJ precision oncology 2024 Mar 1;8(1):58
NPJ precision oncology 2024 Mar 1;8(1):58
Curcumin supplementation alleviates hepatic fat content associated with modulation of gut microbiota-dependent bile acid metabolism in patients with nonalcoholic simple fatty liver disease: a randomized controlled trial.
He Y, Chen X, Li Y, Liang Y, Hong T, Yang J, Cao Z, Mai H, Yao J, Zhang T, Wu K, Zou J, Feng D
The American journal of clinical nutrition 2024 Jul;120(1):66-79
The American journal of clinical nutrition 2024 Jul;120(1):66-79
Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis.
Li J, Sun J, Xu M, Yang L, Yang N, Deng J, Ma Y, Qi Y, Liu Z, Ruan Q, Liu Y, Huang Y
Cellular and molecular life sciences : CMLS 2024 Jul 6;81(1):289
Cellular and molecular life sciences : CMLS 2024 Jul 6;81(1):289
Stigmasterol Activates the mTOR Signaling Pathway by Inhibiting ORP5 Ubiquitination to Promote Milk Synthesis in Bovine Mammary Epithelial Cells.
Sun M, Cao Y, Cheng J, Xu D, Li F, Wang J, Ge Y, Liu Y, Long X, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 Jul 3;72(26):14769-14785
Journal of agricultural and food chemistry 2024 Jul 3;72(26):14769-14785
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.
Li L, Xu S, Wang W, Li X, Wang H, Yang Q, Wang C, Gu J, Luo H, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155693
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155693
Bta-miR-200a Regulates Milk Fat Biosynthesis by Targeting IRS2 to Inhibit the PI3K/Akt Signal Pathway in Bovine Mammary Epithelial Cells.
Tan J, Yang B, Qiu L, He R, Wu Z, Ye M, Zan L, Yang W
Journal of agricultural and food chemistry 2024 Jul 24;72(29):16449-16460
Journal of agricultural and food chemistry 2024 Jul 24;72(29):16449-16460
Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease.
Zhou M, Liu X, Wu Y, Xiang Q, Yu R
Journal of ethnopharmacology 2024 Jul 15;329:118160
Journal of ethnopharmacology 2024 Jul 15;329:118160
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Yang J, Zhang Z, Du X, Wang Y, Meng R, Ge K, Wu C, Liang X, Zhang H, Guo H
Environmental research 2024 Jul 1;252(Pt 4):119113
Environmental research 2024 Jul 1;252(Pt 4):119113
DNAJA1 positively regulates amino acid-stimulated milk protein and fat synthesis in bovine mammary epithelial cells.
Li Z, Yuan X, Wang Y, Sun Z, Ao J
Cell biochemistry and function 2024 Jan;42(1):e3918
Cell biochemistry and function 2024 Jan;42(1):e3918
Valine promotes milk synthesis by regulating PKM2 nuclear accumulation and histone H3 acetylation through the TAS1R1-mTOR-DDX39B signaling pathway.
Cao Y, Hu G, Long X, Li F, Wang J, Sun M, Xie Y, Ge Y, Guo W, Liu J, Fu S
International journal of biological macromolecules 2024 Jan;254(Pt 3):127786
International journal of biological macromolecules 2024 Jan;254(Pt 3):127786
6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway.
Xia Q, Lu F, Chen Y, Li J, Huang Z, Fang K, Hu M, Guo Y, Dong H, Xu L, Gong J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116060
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116060
Si-Ni-San inhibits hepatic Fasn expression and lipid accumulation in MAFLD mice through AMPK/p300/SREBP-1c axis.
Lan T, Geng XJ, Zhang SJ, Zeng XX, Ying JJ, Xu Y, Liu SY, Li P, Tong YH, Wang W, Mao ZJ, Wang SW
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155209
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155209
NAMPT promotes the malignant progression of HBV-associated hepatocellular carcinoma through activation of SREBP1-mediated lipogenesis.
He XL, Guo HJ, Lei YR, Li J, Li JY, Li MH, Li N, Wang F, Mo CF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23444
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23444
Stigmasterol and gastrodin, two major components of banxia-baizhu-tianma decoction, alleviated the excessive phlegm-dampness hypertension by reducing lipid accumulation.
Zhang H, Sun Y, Zou Y, Chen C, Wang S
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117193
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117193
Dietary manganese supplementation decreases hepatic lipid deposition by regulating gene expression and enzyme activity involved in lipid metabolism in the liver of broilers.
Yang K, Cui X, Hu Y, Feng X, Chen W, Zhang W, Zhang L, Li S, Hu Y, Li T, Wang S, Luo X
Journal of animal science 2024 Jan 3;102
Journal of animal science 2024 Jan 3;102
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Huang C, Zhang Y, Xu Y, Wei S, Yang T, Wang S, Li C, Lin H, Li X, Zhao S, Zhu L, Pan W
Aging 2024 Jan 26;16(3):2362-2384
Aging 2024 Jan 26;16(3):2362-2384
Acylated Ghrelin Activates PI3K/mTOR Signaling Pathway by Promoting ThPOK Acetylation to Promote Milk Fat Synthesis in Bovine Mammary Epithelial Cells.
Wang J, Cao Y, Long X, Li F, Jiang N, Sun M, Xie Y, Ge Y, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 Jan 10;72(1):390-404
Journal of agricultural and food chemistry 2024 Jan 10;72(1):390-404
Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate.
Deng R, Zheng Z, Hu S, Wang M, Feng J, Mattjus P, Zhang Z, Zhang Y
Biochimica et biophysica acta. Molecular cell research 2024 Feb;1871(2):119644
Biochimica et biophysica acta. Molecular cell research 2024 Feb;1871(2):119644
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
Xu S, Kong L, Li L, Wang C, Gu J, Luo H, Meng Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Li L, Kong L, Xu S, Wang C, Gu J, Luo H, Meng Q
Hepatology international 2024 Feb;18(1):188-205
Hepatology international 2024 Feb;18(1):188-205
Comprehensive Analysis of Transcriptome and Metabolome Reveals Regulatory Mechanism of Intramuscular Fat Content in Beef Cattle.
Yu H, Yu S, Guo J, Wang J, Mei C, Abbas Raza SH, Cheng G, Zan L
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2911-2924
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2911-2924
PEDV inhibits HNRNPA3 expression by miR-218-5p to enhance cellular lipid accumulation and promote viral replication.
Shi X, Zhang Q, Yang N, Wang Q, Zhang Y, Xu X
mBio 2024 Feb 14;15(2):e0319723
mBio 2024 Feb 14;15(2):e0319723
Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice.
Tong D, Xiang J, Liu W, Sun F, Wang L, Mou A, Cao T, Zhou Q, You M, Liao Y, Gao P, Liu D, Lu Z, Zhu Z
Diabetology & metabolic syndrome 2024 Feb 1;16(1):33
Diabetology & metabolic syndrome 2024 Feb 1;16(1):33
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment.
Chen Y, Tao J, He Y, Hou X, Fang J, Huang J, Wang L, Shen J, Zhu B, Wang N, Cao A
Archives of pharmacal research 2024 Dec;47(12):924-939
Archives of pharmacal research 2024 Dec;47(12):924-939
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Han YL, Yan TT, Li HX, Chen SS, Zhang ZZ, Wang MY, Chen MJ, Chen YL, Yang XX, Wei LL, Duan YJ, Zhang S
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Hepatic miR-363 promotes nonalcoholic fatty liver disease by suppressing INSIG1.
Wang L, Jia G, Fu R, Liang J, Xue W, Zheng J, Qin Y, Zhang M, Meng J
The Journal of nutritional biochemistry 2024 Dec;134:109717
The Journal of nutritional biochemistry 2024 Dec;134:109717
Activated PARP1/FAK/COL5A1 signaling facilitates the tumorigenesis of cholesterol-resistant ovarian cancer cells through promoting EMT.
He Z, Gong S, Zhang X, Li J, Xue J, Zeng Q, Nie J, Zhang Z, Ding H, Pei H, Li B
Cellular signalling 2024 Dec;124:111419
Cellular signalling 2024 Dec;124:111419
Pharmacological inhibition of SREBP1 suppresses pancreatic cancer growth via inducing GPX4-mediated ferroptosis.
Cao R, Feng Z, Mo J, Wu J, Li J, Li W, Wang Z, Ma Q, Wu Z, Zhou C
Cellular signalling 2024 Dec;124:111381
Cellular signalling 2024 Dec;124:111381
Ganoderma lucidum Spore Powder Alleviates Metabolic-Associated Fatty Liver Disease by Improving Lipid Accumulation and Oxidative Stress via Autophagy.
Zhang Y, Zhou J, Yang L, Xiao H, Liu D, Kang X
Antioxidants (Basel, Switzerland) 2024 Dec 9;13(12)
Antioxidants (Basel, Switzerland) 2024 Dec 9;13(12)
Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice.
Zhang Y, Zhao Q, Zhao R, Lu Y, Jiang S, Tang Y
International immunopharmacology 2024 Dec 5;142(Pt A):113154
International immunopharmacology 2024 Dec 5;142(Pt A):113154
Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy.
Wu G, Ying L, Zhang Q, Xiong H, Wang J, Chen S, Yang C, Jin Y, Lai Z, Feng N, Ge Y
Chinese medicine 2024 Dec 26;19(1):178
Chinese medicine 2024 Dec 26;19(1):178
A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy.
Liu J, Xu D, Yan J, Wang B, Zhang L, Liu X, Zhang H, Yan G, Yang J, Zeng Q, Wang X
Photodiagnosis and photodynamic therapy 2024 Aug;48:104238
Photodiagnosis and photodynamic therapy 2024 Aug;48:104238
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Yue C, Lu W, Fan S, Huang Z, Yang J, Dong H, Zhang X, Shang Y, Lai W, Li D, Dong T, Yuan A, Wu J, Kang L, Hu Y
Nature nanotechnology 2024 Aug;19(8):1203-1215
Nature nanotechnology 2024 Aug;19(8):1203-1215
Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics.
Cheng X, Hu Y, Kuang J, Guo X, Cao H, Wu H, Hu G, Zhuang Y
Poultry science 2024 Aug;103(8):103968
Poultry science 2024 Aug;103(8):103968
Regulatory effect of β-glucan secreted by Rhizobium pusense on triglyceride metabolism and their relationships with the modulation of intestinal microbiota in mice fed a high-fat diet.
Zhang B, Zhao W, Song D, Lyu X
Food & function 2024 Aug 27;15(17):8759-8774
Food & function 2024 Aug 27;15(17):8759-8774
Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis.
Wu C, Li J, Jia H, Zhao J, Qin M, Shi H, Liu C, Lin J, Cai M, Gu Y, Liu B, Gao L
Journal of gastroenterology 2024 Apr;59(4):342-356
Journal of gastroenterology 2024 Apr;59(4):342-356
PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8(+)T cells.
Liu SS, Bai TT, Que TL, Luo A, Liang YX, Song YX, Liu TY, Chen JW, Li J, Li N, Zhang ZC, Chen NN, Liu Y, Zhang ZC, Zhou YL, Wang X, Zhu ZB
Veterinary microbiology 2024 Apr;291:110034
Veterinary microbiology 2024 Apr;291:110034
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Lin S, Wang L, Jia Y, Sun Y, Qiao P, Quan Y, Liu J, Hu H, Yang B, Zhou H
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway.
Deng R, Zhu Y, Liu K, Zhang Q, Hu S, Wang M, Zhang Y
Bioorganic chemistry 2024 Apr;145:107212
Bioorganic chemistry 2024 Apr;145:107212
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
Ding J, Liu J, Chen J, Cheng X, Cao H, Guo X, Hu G, Zhuang Y
Poultry science 2024 Apr;103(4):103482
Poultry science 2024 Apr;103(4):103482
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429
Communications biology 2024 Apr 9;7(1):429
Hepatotoxicity induced in rats by chronic exposure to F-53B, an emerging replacement of perfluorooctane sulfonate (PFOS).
Li X, Zhang Q, Wang A, Shan S, Wang X, Wang Y, Wan J, Ning P, Hong C, Tian H, Zhao Y
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123544
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123544
Bufalin Inhibits Tumorigenesis and SREBP-1-Mediated Lipogenesis in Hepatocellular Carcinoma via Modulating the ATP1A1/CA2 Axis.
Huang CJ, Zhang CY, Zhao YK, Wang D, Zhuang L, Qian L, Xie L, Zhu Y, Meng ZQ
The American journal of Chinese medicine 2023;51(2):461-485
The American journal of Chinese medicine 2023;51(2):461-485
The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity.
Xu J, Zhang LW, Feng H, Tang Y, Fu SQ, Liu XM, Zhu XY
Frontiers in pharmacology 2023;14:1176443
Frontiers in pharmacology 2023;14:1176443
Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice.
Wang P, Li R, Li Y, Tan S, Jiang J, Liu H, Wei X
Gastroenterology report 2023;11:goad032
Gastroenterology report 2023;11:goad032
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
Jiang Y, Peng Y, Yang X, Yu J, Yu F, Yuan J, Zha Y
PeerJ 2023;11:e15856
PeerJ 2023;11:e15856
Double-edged effect of sodium citrate in Nile tilapia (Oreochromis niloticus): Promoting lipid and protein deposition vs. causing hyperglycemia and insulin resistance.
Wang JX, Qiao F, Zhang ML, Chen LQ, Du ZY, Luo Y
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Sep;14:303-314
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Sep;14:303-314
High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression.
Stahl F, Schmitt I, Denner P, de Boni L, Wüllner U, Breuer P
Scientific reports 2023 Sep 9;13(1):14911
Scientific reports 2023 Sep 9;13(1):14911
Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2.
Wang S, Zhou Y, Yu R, Ling J, Li B, Yang C, Cheng Z, Qian R, Lin Z, Yu C, Zheng J, Zheng X, Jia Q, Wu W, Wu Q, Chen M, Yuan S, Dong W, Shi Y, Jansen R, Yang C, Hao Y, Yao M, Qin W, Jin H
JHEP reports : innovation in hepatology 2023 Oct;5(10):100843
JHEP reports : innovation in hepatology 2023 Oct;5(10):100843
Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer.
Li T, Liu X, Long X, Li Y, Xiang J, Lv Y, Zhao X, Shi S, Chen W
Environmental toxicology 2023 Oct;38(10):2352-2360
Environmental toxicology 2023 Oct;38(10):2352-2360
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.
Soares VC, Dias SSG, Santos JC, Azevedo-Quintanilha IG, Moreira IBG, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, da Silva MAN, Barreto-Vieira DF, Souza TM, Bozza PT
Life science alliance 2023 Nov;6(11)
Life science alliance 2023 Nov;6(11)
In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages.
Tang T, Xu Y, Wang L, Zhang P
Biotechnology journal 2023 Nov;18(11):e2300108
Biotechnology journal 2023 Nov;18(11):e2300108
Withdrawal.
Photochemistry and photobiology 2023 Nov-Dec;99(6):1501
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Lin Y, Yang M, Huang L, Yang F, Fan J, Qiang Y, Chang Y, Zhou W, Yan L, Xiong J, Ping J, Chen S, Men D, Li F
Cell reports 2023 Nov 28;42(11):113453
Cell reports 2023 Nov 28;42(11):113453
Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
Zhang M, Ma Z, Qi H, Cui X, Li R, Gao X
The British journal of nutrition 2023 Nov 28;130(10):1665-1677
The British journal of nutrition 2023 Nov 28;130(10):1665-1677
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
Lin L, Li X, Wu AJ, Xiu JB, Gan YZ, Yang XM, Ai ZH
iScience 2023 Nov 17;26(11):108226
iScience 2023 Nov 17;26(11):108226
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis.
Zhang J, Liu Y, Li Q, Zuo L, Zhang B, Zhao F, Fan F, Luo S, Hu Y, Sun C
Carcinogenesis 2023 May 27;44(3):242-251
Carcinogenesis 2023 May 27;44(3):242-251
ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells.
Hu Q, Dai J, Zhang Z, Yu H, Zhang J, Zhu X, Qin Y, Zhang L, Zhang P
Cancer research 2023 May 15;83(10):1646-1665
Cancer research 2023 May 15;83(10):1646-1665
Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection.
Doppler C, Messner B, Mimler T, Schachner B, Rezk M, Ganhör C, Wechselberger C, Müller M, Puh S, Pröll J, Arbeithuber B, Müller T, Zierer A, Bernhard D
Journal of lipid research 2023 Mar;64(3):100338
Journal of lipid research 2023 Mar;64(3):100338
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Xu W, Ding J, Li B, Sun T, You X, He Q, Sheng W
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma.
Zhang L, Li XM, Shi XH, Ye K, Fu XL, Wang X, Guo SM, Ma JQ, Xu FF, Sun HM, Li QQ, Zhang WY, Ye LH
Acta pharmacologica Sinica 2023 Mar;44(3):622-634
Acta pharmacologica Sinica 2023 Mar;44(3):622-634
Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation.
Wang D, Zhang M, Xu J, Yang J
Molecules (Basel, Switzerland) 2023 Mar 31;28(7)
Molecules (Basel, Switzerland) 2023 Mar 31;28(7)
ARID3A plays a key regulatory role in palmitic acid-stimulated milk fat synthesis in mouse mammary epithelial cells.
Guo X, Qi H, Lin G, Yu J, Zhang M, Gao X
Cell biology international 2023 Jun;47(6):1106-1117
Cell biology international 2023 Jun;47(6):1106-1117
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
Wu J, Luo J, He Q, Xia Y, Tian H, Zhu L, Li C, Loor JJ
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis.
Yang F, Wu Y, Chen Y, Xi J, Chu Y, Jin J, Yan Y
JHEP reports : innovation in hepatology 2023 Jul;5(7):100746
JHEP reports : innovation in hepatology 2023 Jul;5(7):100746
ORP5 promotes migration and invasion of cervical cancer cells by inhibiting endoplasmic reticulum stress.
Wu Y, Min L, Zhang P, Zhang L, Xu Y, Li D, Zheng M, Pei D, Wang Q
Cell stress & chaperones 2023 Jul;28(4):395-407
Cell stress & chaperones 2023 Jul;28(4):395-407
Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway.
Ding M, Zhou F, Li Y, Liu C, Gu Y, Wu J, Fan G, Li Y, Li X
Chinese herbal medicines 2023 Jul;15(3):421-429
Chinese herbal medicines 2023 Jul;15(3):421-429
Sclareol ameliorates liver injury by inhibiting nuclear factor-kappa B/NOD-like receptor protein 3-mediated inflammation and lipid metabolism disorder in diabetic mice.
Tang L, Mei X, Ye M, Liu Y, Huang Y, Yu J, Zhang L, Zhuge S, Jiang G, Zhu J
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223644
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223644
Goat FADS2 controlling fatty acid metabolism is directly regulated by SREBP1 in mammary epithelial cells.
Wu J, Luo J, Xia Y, An X, Guo P, He Q, Tian H, Hu Q, Li C, Wang H
Journal of animal science 2023 Jan 3;101
Journal of animal science 2023 Jan 3;101
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes.
Du ZQ, Pang YQ, Zhang Y, Wang L, Zhang R, Li H, Yang CX
Poultry science 2023 Feb;102(2):102363
Poultry science 2023 Feb;102(2):102363
Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway.
Lei Z, Ali I, Yang M, Yang C, Li Y, Li L
Antioxidants (Basel, Switzerland) 2023 Feb 9;12(2)
Antioxidants (Basel, Switzerland) 2023 Feb 9;12(2)
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638
Nature communications 2023 Feb 6;14(1):638
miR-33a Inhibits the Differentiation of Bovine Preadipocytes through the IRS2-Akt Pathway.
Zhang W, Raza SHA, Li B, Sun B, Wang S, Pant SD, Al-Abbas NS, Shaer NA, Zan L
Genes 2023 Feb 20;14(2)
Genes 2023 Feb 20;14(2)
Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
Zhang S, You Y, Li Y, Yuan H, Zhou J, Tian L, Liu Y, Wang B, Zhu E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23266
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23266
Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells.
Qi H, Lin G, Guo S, Guo X, Yu C, Zhang M, Gao X
Animal biotechnology 2023 Dec;34(8):4094-4104
Animal biotechnology 2023 Dec;34(8):4094-4104
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Zhang S, Wang M, Li H, Li Q, Liu N, Dong S, Zhao Y, Pang K, Huang J, Ren C, Wang Y, Tian Z, Lu F, Zhang W
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
Duan J, Dong W, Wang G, Xiu W, Pu G, Xu J, Ye C, Zhang X, Zhu Y, Wang C
Nature communications 2023 Dec 9;14(1):8151
Nature communications 2023 Dec 9;14(1):8151
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
La Y, Wong W, Peng K, Tian Z, Pan J, Sun R, Luan J, Yan K, Zhang Q, Zhang Z
Inflammation 2023 Aug;46(4):1575-1586
Inflammation 2023 Aug;46(4):1575-1586
3D artificial sebocyte glands from inertial focusing effect for facile and flexible analysis of light damage and drug screening.
Tang T, Wei Y, Jia H, Wang L, Xu Y, Zhang P
Biotechnology journal 2023 Aug;18(8):e2200634
Biotechnology journal 2023 Aug;18(8):e2200634
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway.
Chen S, Sun S, Feng Y, Li X, Yin G, Liang P, Yu W, Meng D, Zhang X, Liu H, Zhang F
European journal of pharmacology 2023 Aug 5;952:175808
European journal of pharmacology 2023 Aug 5;952:175808
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Zhou X, Li Y, Yang C, Chen D, Wang T, Liu T, Yan W, Su Z, Peng B, Ren X
Life sciences 2023 Aug 15;327:121698
Life sciences 2023 Aug 15;327:121698
DAXX drives de novo lipogenesis and contributes to tumorigenesis.
Mahmud I, Tian G, Wang J, Hutchinson TE, Kim BJ, Awasthee N, Hale S, Meng C, Moore A, Zhao L, Lewis JE, Waddell A, Wu S, Steger JM, Lydon ML, Chait A, Zhao LY, Ding H, Li JL, Purayil HT, Huo Z, Daaka Y, Garrett TJ, Liao D
Nature communications 2023 Apr 12;14(1):1927
Nature communications 2023 Apr 12;14(1):1927
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Gu W, Yang L, Wang X, Geng J, Li X, Zheng K, Guan Y, Hou X, Wang C, Song G
Kidney & blood pressure research 2022;47(8):514-522
Kidney & blood pressure research 2022;47(8):514-522
Roxadustat, a Hypoxia-Inducible Factor 1α Activator, Attenuates Both Long- and Short-Term Alcohol-Induced Alcoholic Liver Disease.
Gao Y, Jiang X, Yang D, Guo W, Wang D, Gong K, Peng Y, Jiang H, Shi C, Duan Y, Chen Y, Han J, Yang X
Frontiers in pharmacology 2022;13:895710
Frontiers in pharmacology 2022;13:895710
Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer.
Chen H, Qi Q, Wu N, Wang Y, Feng Q, Jin R, Jiang L
Redox biology 2022 Sep;55:102426
Redox biology 2022 Sep;55:102426
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
Cheng J, Xu D, Chen L, Guo W, Hu G, Liu J, Fu S
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Wang Y, Wang HL, Lin ZP, Zhong JF, Chen KL, Duan X
Molecular biology reports 2022 Oct;49(10):9297-9305
Molecular biology reports 2022 Oct;49(10):9297-9305
Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway.
Zhou C, Li P, Han M, Gao X
Animal biotechnology 2022 Oct;33(5):851-863
Animal biotechnology 2022 Oct;33(5):851-863
The interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis.
Wang Y, Zhang Y, Wang Z, Yu L, Chen K, Xie Y, Liu Y, Liang W, Zheng Y, Zhan Y, Ding Y
Cell death discovery 2022 Oct 28;8(1):431
Cell death discovery 2022 Oct 28;8(1):431
Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.
Hu S, Feng J, Wang M, Wufuer R, Liu K, Zhang Z, Zhang Y
Redox biology 2022 Nov;57:102470
Redox biology 2022 Nov;57:102470
GPRC6A is a key mediator of palmitic acid regulation of lipid synthesis in bovine mammary epithelial cells.
Jin X, Zhen Z, Wang Z, Gao X, Li M
Cell biology international 2022 Nov;46(11):1747-1758
Cell biology international 2022 Nov;46(11):1747-1758
SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs.
Ding Q, Wang Y, Xia SW, Zhao F, Zhong JF, Wang HL, Chen KL
International journal of molecular sciences 2022 Nov 1;23(21)
International journal of molecular sciences 2022 Nov 1;23(21)
Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma.
Narahara S, Watanabe T, Nagaoka K, Fujimoto N, Furuta Y, Tanaka K, Tokunaga T, Kawasaki T, Yoshimaru Y, Setoyama H, Oniki K, Saruwatari J, Tateyama M, Naoe H, Tanaka M, Tanaka Y, Sasaki Y
Hepatology communications 2022 May;6(5):1198-1212
Hepatology communications 2022 May;6(5):1198-1212
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Li T, Chen Y, Tan P, Shi H, Huang Z, Cai T, Cheng Y, Du Y, Fu W
Bioorganic chemistry 2022 May;122:105737
Bioorganic chemistry 2022 May;122:105737
VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells.
Temerozo JR, Sacramento CQ, Fintelman-Rodrigues N, Pão CRR, de Freitas CS, Dias SSG, Ferreira AC, Mattos M, Soares VC, Teixeira L, Azevedo-Quintanilha IG, Hottz ED, Kurtz P, Bozza FA, Bozza PT, Souza TML, Bou-Habib DC
Journal of leukocyte biology 2022 May;111(5):1107-1121
Journal of leukocyte biology 2022 May;111(5):1107-1121
Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling.
Hao Q, Wang Z, Wang L, Han M, Zhang M, Gao X
The British journal of nutrition 2022 May 20;:1-11
The British journal of nutrition 2022 May 20;:1-11
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Zhang W, Ho CT, Lu M
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.
Zeng H, Qin H, Liao M, Zheng E, Luo X, Xiao A, Li Y, Chen L, Wei L, Zhao L, Ruan XZ, Yang P, Chen Y
Molecular metabolism 2022 Mar;57:101428
Molecular metabolism 2022 Mar;57:101428
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Li S, Wang C, Wu Z
Amino acids 2022 Mar;54(3):339-351
Amino acids 2022 Mar;54(3):339-351
METTL3 is a key regulator of milk synthesis in mammary epithelial cells.
Wang L, Qi H, Li D, Liu L, Chen D, Gao X
Cell biology international 2022 Mar;46(3):359-369
Cell biology international 2022 Mar;46(3):359-369
Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).
Zhang Y, Ge L, Song G, Zhang R, Li S, Shi H, Zhang H, Li Y, Pan J, Wang L, Han J
British journal of pharmacology 2022 Mar;179(6):1201-1219
British journal of pharmacology 2022 Mar;179(6):1201-1219
The lncRNA ZFAS1 regulates lipogenesis in colorectal cancer by binding polyadenylate-binding protein 2 to stabilize SREBP1 mRNA.
Wang H, Chen Y, Liu Y, Li Q, Luo J, Wang L, Chen Y, Sang C, Zhang W, Ge X, Yao Z, Miao L, Liu X
Molecular therapy. Nucleic acids 2022 Mar 8;27:363-374
Molecular therapy. Nucleic acids 2022 Mar 8;27:363-374
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway.
Gu W, Wang X, Zhao H, Geng J, Li X, Zheng K, Guan Y, Hou X, Wang C, Song G
European journal of pharmacology 2022 Mar 5;918:174776
European journal of pharmacology 2022 Mar 5;918:174776
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Wang Y, Wang Y, Li F, Zou J, Li X, Xu M, Yu D, Ma Y, Huang W, Sun X, Zhang Y
Cells 2022 Mar 22;11(7)
Cells 2022 Mar 22;11(7)
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
Luo M, Ma X, Jiang W, Zhang J, Liu W, Wei S, Liu H
European journal of medicinal chemistry 2022 Mar 15;232:114168
European journal of medicinal chemistry 2022 Mar 15;232:114168
Divergent transcriptional regulation of astrocyte reactivity across disorders.
Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564
Nature 2022 Jun;606(7914):557-564
Amelioration action of gastrodigenin rhamno-pyranoside from Moringa seeds on non-alcoholic fatty liver disease.
Liao M, Sun C, Li R, Li W, Ge Z, Adu-Frimpong M, Xu X, Yu J
Food chemistry 2022 Jun 15;379:132087
Food chemistry 2022 Jun 15;379:132087
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
Song CC, Pantopoulos K, Chen GH, Zhong CC, Zhao T, Zhang DG, Luo Z
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis.
Qi Y, Zhang H, Fan H, Wang X, Zhao A, Tian Y, Yang G, Li C, Wei J, Yao W, Hao C
Environmental pollution (Barking, Essex : 1987) 2022 Jan 1;292(Pt A):118272
Environmental pollution (Barking, Essex : 1987) 2022 Jan 1;292(Pt A):118272
A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD.
Shao Y, Yao Z, Zhou J, Yu M, Chen S, Yuan Y, Han L, Jiang L, Liu J
Nutrition & metabolism 2022 Dec 6;19(1):80
Nutrition & metabolism 2022 Dec 6;19(1):80
Elevated thyroid hormones caused by high concentrate diets participate in hepatic metabolic disorders in dairy cows.
Chen Q, Wu C, Yao Z, Cai L, Ni Y, Mao S
Animal bioscience 2022 Aug;35(8):1184-1194
Animal bioscience 2022 Aug;35(8):1184-1194
Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.
Fang Y, Fang D
Gene 2022 Aug 5;834:146594
Gene 2022 Aug 5;834:146594
Redox-Unlockable Nanoparticle-Based MST1 Delivery System to Attenuate Hepatic Steatosis via the AMPK/SREBP-1c Signaling Axis.
Li Y, Nie JJ, Yang Y, Li J, Li J, Wu X, Liu X, Chen DF, Yang Z, Xu FJ, Yang Y
ACS applied materials & interfaces 2022 Aug 3;14(30):34328-34341
ACS applied materials & interfaces 2022 Aug 3;14(30):34328-34341
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Stearic Acid Activates the PI3K-mTOR-4EBP1/S6K and mTOR-SREBP-1 Signaling Axes through FATP4-CDK1 To Promote Milk Synthesis in Primary Bovine Mammary Epithelial Cells.
Li F, Hu G, Long X, Cao Y, Li Q, Guo W, Wang J, Liu J, Fu S
Journal of agricultural and food chemistry 2022 Apr 6;70(13):4007-4018
Journal of agricultural and food chemistry 2022 Apr 6;70(13):4007-4018
Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression.
Jin Y, Tan Y, Zhao P, Guo Y, Chen S, Wu J, Ren Z
Communications biology 2022 Apr 6;5(1):326
Communications biology 2022 Apr 6;5(1):326
SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation.
Yuan Y, Zhou D, Chen F, Yang Z, Gu W, Zhang K
Cell death & disease 2022 Apr 6;13(4):312
Cell death & disease 2022 Apr 6;13(4):312
L-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice.
Wang Y, Zhao J, Li Q, Liu J, Sun Y, Zhang K, Fan M, Qian H, Li Y, Wang L
Nutrition & metabolism 2022 Apr 15;19(1):30
Nutrition & metabolism 2022 Apr 15;19(1):30
L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway.
Liang J, Gu L, Liu X, Yan X, Bi X, Fan X, Zhou J, Lu S, Luo L, Yin Z
Nutrition & metabolism 2022 Apr 15;19(1):29
Nutrition & metabolism 2022 Apr 15;19(1):29
The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes.
Kong M, Zhu Y, Shao J, Fan Z, Xu Y
Frontiers in cell and developmental biology 2021;9:622866
Frontiers in cell and developmental biology 2021;9:622866
BRG1 Links TLR4 Trans-Activation to LPS-Induced SREBP1a Expression and Liver Injury.
Dong W, Zhu Y, Zhang Y, Fan Z, Zhang Z, Fan X, Xu Y
Frontiers in cell and developmental biology 2021;9:617073
Frontiers in cell and developmental biology 2021;9:617073
Multi-Omics Analysis of Mammary Metabolic Changes in Dairy Cows Exposed to Hypoxia.
Kong Z, Li B, Zhou C, He Q, Zheng Y, Tan Z
Frontiers in veterinary science 2021;8:764135
Frontiers in veterinary science 2021;8:764135
An Integrated Transcriptomics and Proteomics Analysis Implicates lncRNA MALAT1 in the Regulation of Lipid Metabolism.
Wang H, Zhang Y, Guan X, Li X, Zhao Z, Gao Y, Zhang X, Chen R
Molecular & cellular proteomics : MCP 2021;20:100141
Molecular & cellular proteomics : MCP 2021;20:100141
Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice.
Li H, Sheng J, Wang J, Gao H, Yu J, Ding G, Ding N, He W, Zha J
Drug design, development and therapy 2021;15:2309-2324
Drug design, development and therapy 2021;15:2309-2324
JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.
Wang K, Cui Y, Lin P, Yao Z, Sun Y
Frontiers in endocrinology 2021;12:689845
Frontiers in endocrinology 2021;12:689845
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Meng H, Shen M, Li J, Zhang R, Li X, Zhao L, Huang G, Liu J
European journal of pharmacology 2021 Sep 5;906:174280
European journal of pharmacology 2021 Sep 5;906:174280
LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.
Guo S, Zhang Y, Wang S, Yang T, Ma B, Li X, Zhang Y, Jiang X
Toxicology letters 2021 Sep 15;348:50-58
Toxicology letters 2021 Sep 15;348:50-58
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
Tao M, Luo J, Gu T, Yu X, Song Z, Jun Y, Gu H, Han K, Huang X, Yu W, Sun S, Zhang Z, Liu L, Chen X, Zhang L, Luo C, Wang Q
Cell death & disease 2021 Sep 13;12(9):845
Cell death & disease 2021 Sep 13;12(9):845
The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathway.
Meng Z, Liu X, Li T, Fang T, Cheng Y, Han L, Sun B, Chen L
International immunopharmacology 2021 May;94:107492
International immunopharmacology 2021 May;94:107492
UFL1 regulates milk protein and fat synthesis-related gene expression of bovine mammary epithelial cells probably via the mTOR signaling pathway.
Li C, Li L, Ali I, Kuang M, Wang X, Wang G
In vitro cellular & developmental biology. Animal 2021 May;57(5):550-559
In vitro cellular & developmental biology. Animal 2021 May;57(5):550-559
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
Wang D, Yin Z, Ma L, Han L, Chen Y, Pan W, Gong K, Gao Y, Yang X, Chen Y, Han J, Duan Y
Food & function 2021 Jun 7;12(11):4842-4854
Food & function 2021 Jun 7;12(11):4842-4854
A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice.
Li X, Yang L, Li J, Lin L, Zheng G
Food & function 2021 Jul 5;12(13):5862-5875
Food & function 2021 Jul 5;12(13):5862-5875
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer.
Li LY, Yang Q, Jiang YY, Yang W, Jiang Y, Li X, Hazawa M, Zhou B, Huang GW, Xu XE, Gery S, Zhang Y, Ding LW, Ho AS, Zumsteg ZS, Wang MR, Fullwood MJ, Freedland SJ, Meltzer SJ, Xu LY, Li EM, Koeffler HP, Lin DC
Nature communications 2021 Jul 16;12(1):4362
Nature communications 2021 Jul 16;12(1):4362
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
Luo N, Yang C, Zhu Y, Chen Q, Zhang B
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Gong X, Li T, Wan R, Sha L
International immunopharmacology 2021 Feb;91:107173
International immunopharmacology 2021 Feb;91:107173
Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice.
Wen F, Shi Z, Liu X, Tan Y, Wei L, Zhu X, Zhang H, Zhu X, Meng X, Ji W, Yang M, Lu Z
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2021 Feb;53(2):132-144
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2021 Feb;53(2):132-144
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Huang D, Xu B, Liu L, Wu L, Zhu Y, Ghanbarpour A, Wang Y, Chen FJ, Lyu J, Hu Y, Kang Y, Zhou W, Wang X, Ding W, Li X, Jiang Z, Chen J, Zhang X, Zhou H, Li JZ, Guo C, Zheng W, Zhang X, Li P, Melia T, Reinisch K, Chen XW
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Chen W, Zhang X, Xu M, Jiang L, Zhou M, Liu W, Chen Z, Wang Y, Zou Q, Wang L
European journal of nutrition 2021 Apr;60(3):1655-1668
European journal of nutrition 2021 Apr;60(3):1655-1668
Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.
Cao Y, Hu G, Zhang Q, Ma L, Wang J, Li W, Ge Y, Cheng J, Yang Z, Fu S, Liu J
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4093-4100
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4093-4100
Compound C enhances the anticancer effect of aspirin in HER-2-positive breast cancer by regulating lipid metabolism in an AMPK-independent pathway.
Wu Y, Yan B, Xu W, Guo L, Wang Z, Li G, Hou N, Zhang J, Ling R
International journal of biological sciences 2020;16(4):583-597
International journal of biological sciences 2020;16(4):583-597
Delivery of microRNA-33 Antagomirs by Mesoporous Silica Nanoparticles to Ameliorate Lipid Metabolic Disorders.
Tao Y, Xu S, Wang J, Xu L, Zhang C, Chen K, Lian Z, Zhou J, Xie H, Zheng S, Xu X
Frontiers in pharmacology 2020;11:921
Frontiers in pharmacology 2020;11:921
Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer.
Guo S, Ma B, Jiang X, Li X, Jia Y
Frontiers in pharmacology 2020;11:598
Frontiers in pharmacology 2020;11:598
SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β-catenin signaling pathway.
Wang J, Ling R, Zhou Y, Gao X, Yang Y, Mao C, Chen D
Oncology letters 2020 Sep;20(3):2855-2869
Oncology letters 2020 Sep;20(3):2855-2869
Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress.
Peng Y, Yang X, Luo X, Liu C, Cao X, Wang H, Guo L
Biological research 2020 Oct 27;53(1):50
Biological research 2020 Oct 27;53(1):50
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Feng Z, Pang L, Chen S, Pang X, Huang Y, Qiao Q, Wang Y, Vonglorkham S, Huang Q, Lin X, Wei J
International immunopharmacology 2020 Nov;88:107003
International immunopharmacology 2020 Nov;88:107003
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Omer NA, Hu Y, Idriss AA, Abobaker H, Hou Z, Yang S, Ma W, Zhao R
Poultry science 2020 Jun;99(6):3121-3132
Poultry science 2020 Jun;99(6):3121-3132
Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy.
He Q, Wang L, Zhao R, Yan F, Sha S, Cui C, Song J, Hu H, Guo X, Yang M, Cui Y, Sun Y, Sun Z, Liu F, Dong M, Hou X, Chen L
Stem cell research & therapy 2020 Jun 8;11(1):223
Stem cell research & therapy 2020 Jun 8;11(1):223
Viburnum opulus L. Juice Phenolics Inhibit Mouse 3T3-L1 Cells Adipogenesis and Pancreatic Lipase Activity.
Zakłos-Szyda M, Pietrzyk N, Szustak M, Podsędek A
Nutrients 2020 Jul 6;12(7)
Nutrients 2020 Jul 6;12(7)
Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes.
Wang H, Cao Y, Shu L, Zhu Y, Peng Q, Ran L, Wu J, Luo Y, Zuo G, Luo J, Zhou L, Shi Q, Weng Y, Huang A, He TC, Fan J
Journal of cellular and molecular medicine 2020 Jan;24(2):1399-1412
Journal of cellular and molecular medicine 2020 Jan;24(2):1399-1412
Sesamol Alleviates Obesity-Related Hepatic Steatosis via Activating Hepatic PKA Pathway.
Xu HY, Yu L, Chen JH, Yang LN, Lin C, Shi XQ, Qin H
Nutrients 2020 Jan 26;12(2)
Nutrients 2020 Jan 26;12(2)
A metastasis map of human cancer cell lines.
Jin X, Demere Z, Nair K, Ali A, Ferraro GB, Natoli T, Deik A, Petronio L, Tang AA, Zhu C, Wang L, Rosenberg D, Mangena V, Roth J, Chung K, Jain RK, Clish CB, Vander Heiden MG, Golub TR
Nature 2020 Dec;588(7837):331-336
Nature 2020 Dec;588(7837):331-336
ZHX2 inhibits SREBP1c-mediated de novo lipogenesis in hepatocellular carcinoma via miR-24-3p.
Yu X, Lin Q, Wu Z, Zhang Y, Wang T, Zhao S, Song X, Chen C, Wang Z, Xu L, Li C, Gao L, Liang X, Yue X, Ma C
The Journal of pathology 2020 Dec;252(4):358-370
The Journal of pathology 2020 Dec;252(4):358-370
Exosomal miR-199a-5p promotes hepatic lipid accumulation by modulating MST1 expression and fatty acid metabolism.
Li Y, Luan Y, Li J, Song H, Li Y, Qi H, Sun B, Zhang P, Wu X, Liu X, Yang Y, Tao W, Cai L, Yang Z, Yang Y
Hepatology international 2020 Dec;14(6):1057-1074
Hepatology international 2020 Dec;14(6):1057-1074
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Zhao Y, Li M, Yao X, Fei Y, Lin Z, Li Z, Cai K, Zhao Y, Luo Z
Cell reports 2020 Dec 8;33(10):108487
Cell reports 2020 Dec 8;33(10):108487
GRP78 regulates milk biosynthesis and the proliferation of bovinemammaryepithelial cells through the mTOR signaling pathway.
Liu Y, Wang X, Zhen Z, Yu Y, Qiu Y, Xiang W
Cellular & molecular biology letters 2019;24:57
Cellular & molecular biology letters 2019;24:57
MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway.
Chao H, Deng L, Xu F, Yu Z, Xu X, Huang J, Zeng T
OncoTargets and therapy 2019;12:3285-3294
OncoTargets and therapy 2019;12:3285-3294
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
Liu G, Kuang S, Cao R, Wang J, Peng Q, Sun C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
NUCKS1 is a novel regulator of milk synthesis in and proliferation of mammary epithelial cells via the mTOR signaling pathway.
Yuan X, Zhang M, Ao J, Zhen Z, Gao X, Li M
Journal of cellular physiology 2019 Sep;234(9):15825-15835
Journal of cellular physiology 2019 Sep;234(9):15825-15835
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.
He W, Xu Y, Ren X, Xiang D, Lei K, Zhang C, Liu D
Digestive diseases and sciences 2019 Nov;64(11):3182-3191
Digestive diseases and sciences 2019 Nov;64(11):3182-3191
Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes.
Wu L, Wang Y, Chi G, Shen B, Tian Y, Li Z, Han L, Zhang Q, Feng H
Journal of cellular physiology 2019 Nov;234(11):19785-19798
Journal of cellular physiology 2019 Nov;234(11):19785-19798
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, Sun M, Chen B, Zhao W, Wang L, Wang H, Moran MS, Haffty BG, Yang Q
Cell death and differentiation 2019 May;26(5):843-859
Cell death and differentiation 2019 May;26(5):843-859
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
Wang Y, Guo D, He J, Song L, Chen H, Zhang Z, Tan N
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
U2AF65 enhances milk synthesis and growth of bovine mammary epithelial cells by positively regulating the mTOR-SREBP-1c signalling pathway.
Yu Y, Zhen Z, Qi H, Yuan X, Gao X, Zhang M
Cell biochemistry and function 2019 Mar;37(2):93-101
Cell biochemistry and function 2019 Mar;37(2):93-101
Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha.
Ren L, Sun D, Zhou X, Yang Y, Huang X, Li Y, Wang C, Li Y
Journal of ethnopharmacology 2019 Mar 25;232:176-187
Journal of ethnopharmacology 2019 Mar 25;232:176-187
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Ran L, Wang X, Mi A, Liu Y, Wu J, Wang H, Guo M, Sun J, Liu B, Li Y, Wang D, Jiang R, Wang N, Gao W, Zeng L, Huang L, Chen X, LeRoith D, Liang B, Li X, Wu Y
iScience 2019 Jun 28;16:106-121
iScience 2019 Jun 28;16:106-121
Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells.
Li X, Li P, Wang L, Zhang M, Gao X
Journal of agricultural and food chemistry 2019 Jun 26;67(25):7005-7015
Journal of agricultural and food chemistry 2019 Jun 26;67(25):7005-7015
microRNA-16-5p promotes 3T3-L1 adipocyte differentiation through regulating EPT1.
Xu J, Zhang L, Shu G, Wang B
Biochemical and biophysical research communications 2019 Jul 5;514(4):1251-1256
Biochemical and biophysical research communications 2019 Jul 5;514(4):1251-1256
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Li Q, Wang Y, Wu S, Zhou Z, Ding X, Shi R, Thorne RF, Zhang XD, Hu W, Wu M
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Fibronectin type III domain-containing protein 5 promotes proliferation and differentiation of goat adipose-derived stem cells.
Dong Y, Zhang S, Tao J, Zhang X, Zhang J, Yang J, Liang H, Liu D, Cang M
Research in veterinary science 2019 Aug;125:351-359
Research in veterinary science 2019 Aug;125:351-359
Cyclase-associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells.
Yuan X, Zhen Z, Zhang M, Yu Y, Gao X, Ao JX
Cell biochemistry and function 2019 Apr;37(3):185-192
Cell biochemistry and function 2019 Apr;37(3):185-192
Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor α Activation.
Tian Y, Feng H, Han L, Wu L, Lv H, Shen B, Li Z, Zhang Q, Liu G
Frontiers in immunology 2018;9:147
Frontiers in immunology 2018;9:147
Downregulation of microRNA-1 attenuates glucose-induced apoptosis by regulating the liver X receptor α in cardiomyocytes.
Cheng Y, Zhao W, Zhang X, Sun L, Yang H, Wang Y, Cao Y, Chu Y, Liu G
Experimental and therapeutic medicine 2018 Sep;16(3):1814-1824
Experimental and therapeutic medicine 2018 Sep;16(3):1814-1824
NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression.
Qin DD, Yang YF, Pu ZQ, Liu D, Yu C, Gao P, Chen JC, Zong C, Zhang YC, Li X, Wang XD, Liu YT
Journal of cellular and molecular medicine 2018 Oct;22(10):4709-4720
Journal of cellular and molecular medicine 2018 Oct;22(10):4709-4720
CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.
Zhang H, Zhang C, Tang H, Gao S, Sun F, Yang Y, Zhou W, Hu Y, Ke C, Wu Y, Ding Z, Guo L, Pei R, Chen X, Sy MS, Zhang B, Li C
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1710-1725
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1710-1725
Mitochondrial ATAD3A regulates milk biosynthesis and proliferation of mammary epithelial cells from dairy cow via the mTOR pathway.
Chen D, Yuan X, Liu L, Zhang M, Qu B, Zhen Z, Gao X
Cell biology international 2018 May;42(5):533-542
Cell biology international 2018 May;42(5):533-542
Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.
Tian S, Li B, Lei P, Yang X, Zhang X, Bao Y, Shan Y
Molecular nutrition & food research 2018 Mar;62(6):e1700737
Molecular nutrition & food research 2018 Mar;62(6):e1700737
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Chen S, Li X, Liu L, Liu C, Han X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway.
Zhang M, Chen D, Zhen Z, Ao J, Yuan X, Gao X
Journal of cellular physiology 2018 Mar;233(3):2464-2475
Journal of cellular physiology 2018 Mar;233(3):2464-2475
MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study.
Yang Y, Jiang H, Xiao L, Yang X
Oncology reports 2018 Jun;39(6):3073-3085
Oncology reports 2018 Jun;39(6):3073-3085
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Qiao X, Li Y, Mai J, Ji X, Li Q
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.
Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB
The Journal of biological chemistry 2018 Jul 20;293(29):11341-11357
The Journal of biological chemistry 2018 Jul 20;293(29):11341-11357
DEAD-box helicase 6 (DDX6) is a new negative regulator for milk synthesis and proliferation of bovine mammary epithelial cells.
Zhen Z, Zhang M, Yuan X, Qu B, Yu Y, Gao X, Qiu Y
In vitro cellular & developmental biology. Animal 2018 Jan;54(1):52-60
In vitro cellular & developmental biology. Animal 2018 Jan;54(1):52-60
Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice.
Zhang J, Zhang H, Deng X, Zhang N, Liu B, Xin S, Li G, Xu K
Life sciences 2018 Jan 1;192:46-54
Life sciences 2018 Jan 1;192:46-54
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Duan X, Meng Q, Wang C, Liu Z, Sun H, Huo X, Sun P, Ma X, Peng J, Liu K
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis.
Zhong H, Chen K, Feng M, Shao W, Wu J, Chen K, Liang T, Liu C
The FEBS journal 2018 Feb;285(3):501-517
The FEBS journal 2018 Feb;285(3):501-517
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout.
Zhang J, Zhao J, Zheng X, Cai K, Mao Q, Xia H
Molecular medicine reports 2018 Feb;17(2):2169-2176
Molecular medicine reports 2018 Feb;17(2):2169-2176
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, Bai F, Sun X, Lin X, Wei J
International immunopharmacology 2018 Dec;65:256-267
International immunopharmacology 2018 Dec;65:256-267
Chronic dexamethasone exposure markedly decreased the hepatic triglyceride accumulation in growing goats.
Chen Q, Niu L, Hua C, Geng Y, Cai L, Tao S, Ni Y, Zhao R
General and comparative endocrinology 2018 Apr 1;259:115-121
General and comparative endocrinology 2018 Apr 1;259:115-121
Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway.
Li L, Liu L, Qu B, Li X, Gao X, Zhang M
Biochemical and biophysical research communications 2017 Oct 21;492(3):289-294
Biochemical and biophysical research communications 2017 Oct 21;492(3):289-294
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Gao Y, Li J, Xu X, Wang S, Yang Y, Zhou J, Zhang L, Zheng F, Li X, Wang B
International journal of obesity (2005) 2017 May;41(5):729-738
International journal of obesity (2005) 2017 May;41(5):729-738
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.
Hu Y, Sun Q, Zong Y, Liu J, Idriss AA, Omer NA, Zhao R
General and comparative endocrinology 2017 May 15;246:241-248
General and comparative endocrinology 2017 May 15;246:241-248
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Meng Q, Duan XP, Wang CY, Liu ZH, Sun PY, Huo XK, Sun HJ, Peng JY, Liu KX
Acta pharmacologica Sinica 2017 Jan;38(1):69-79
Acta pharmacologica Sinica 2017 Jan;38(1):69-79
B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.
Luo D, Xiao H, Dong J, Li Y, Feng G, Cui M, Fan S
Biochemical and biophysical research communications 2017 Jan 22;482(4):1246-1251
Biochemical and biophysical research communications 2017 Jan 22;482(4):1246-1251
Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner.
Bai J, Wang P, Liu Y, Zhang Y, Li Y, He Z, Hou L, Liang R
Environmental toxicology and pharmacology 2017 Dec;56:15-20
Environmental toxicology and pharmacology 2017 Dec;56:15-20
Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis.
Wang B, Fu J, Li L, Gong D, Wen X, Yu P, Zeng Z
International journal of food sciences and nutrition 2016;67(3):288-97
International journal of food sciences and nutrition 2016;67(3):288-97
Sodium sulfite promotes the assembly and secretion of very low-density lipoprotein in HL-7702 hepatocytes.
Bai J, Lei P, Zhao C, Wang Y, Yan D, Yang S
Toxicology reports 2016;3:98-104
Toxicology reports 2016;3:98-104
Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice.
Wang C, Duan X, Sun X, Liu Z, Sun P, Yang X, Sun H, Liu K, Meng Q
Food & function 2016 Sep 14;7(9):3716-23
Food & function 2016 Sep 14;7(9):3716-23
MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling.
Jin M, Wu Y, Wang J, Chen J, Huang Y, Rao J, Feng C
Biochemical and biophysical research communications 2016 May 20;474(1):76-82
Biochemical and biophysical research communications 2016 May 20;474(1):76-82
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q
Journal of lipid research 2016 Aug;57(8):1398-411
Journal of lipid research 2016 Aug;57(8):1398-411
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer.
Ji S, Qin Y, Shi S, Liu X, Hu H, Zhou H, Gao J, Zhang B, Xu W, Liu J, Liang D, Liu L, Liu C, Long J, Zhou H, Chiao PJ, Xu J, Ni Q, Gao D, Yu X
Cell research 2015 May;25(5):561-73
Cell research 2015 May;25(5):561-73
Supplementation of chitosan alleviates high-fat diet-enhanced lipogenesis in rats via adenosine monophosphate (AMP)-activated protein kinase activation and inhibition of lipogenesis-associated genes.
Chiu CY, Chan IL, Yang TH, Liu SH, Chiang MT
Journal of agricultural and food chemistry 2015 Mar 25;63(11):2979-88
Journal of agricultural and food chemistry 2015 Mar 25;63(11):2979-88
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang X
Cancer research 2015 Mar 1;75(5):846-57
Cancer research 2015 Mar 1;75(5):846-57
RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction.
Hu YW, Zhao JY, Li SF, Huang JL, Qiu YR, Ma X, Wu SG, Chen ZP, Hu YR, Yang JY, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q
Arteriosclerosis, thrombosis, and vascular biology 2015 Jan;35(1):87-101
Arteriosclerosis, thrombosis, and vascular biology 2015 Jan;35(1):87-101
LXRalpha gene downregulation by lentiviral-based RNA interference enhances liver function after fatty liver transplantation in rats.
Zhao YP, Li L, Ma JP, Chen G, Bai JH
Hepatobiliary & pancreatic diseases international : HBPD INT 2015 Aug;14(4):386-93
Hepatobiliary & pancreatic diseases international : HBPD INT 2015 Aug;14(4):386-93
Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.
Wang Q, Wang ST, Yang X, You PP, Zhang W
Nutrition research (New York, N.Y.) 2015 Apr;35(4):317-27
Nutrition research (New York, N.Y.) 2015 Apr;35(4):317-27
Pleiotropic effects of cavin-1 deficiency on lipid metabolism.
Ding SY, Lee MJ, Summer R, Liu L, Fried SK, Pilch PF
The Journal of biological chemistry 2014 Mar 21;289(12):8473-83
The Journal of biological chemistry 2014 Mar 21;289(12):8473-83
A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Hu YW, Yang JY, Ma X, Chen ZP, Hu YR, Zhao JY, Li SF, Qiu YR, Lu JB, Wang YC, Gao JJ, Sha YH, Zheng L, Wang Q
Journal of lipid research 2014 Apr;55(4):681-97
Journal of lipid research 2014 Apr;55(4):681-97
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
Hu YW, Ma X, Huang JL, Mao XR, Yang JY, Zhao JY, Li SF, Qiu YR, Yang J, Zheng L, Wang Q
PloS one 2013;8(6):e66876
PloS one 2013;8(6):e66876
OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62.
Zhou T, Li S, Zhong W, Vihervaara T, Béaslas O, Perttilä J, Luo W, Jiang Y, Lehto M, Olkkonen VM, Yan D
PloS one 2011;6(6):e21078
PloS one 2011;6(6):e21078
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14088-1-AP(SREBF1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SREBF1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SREBF1. This antibody recognizes human antigen. The SREBF1 antibody has been validated for the following applications: ELISA, WB, IP analysis.
