Antibody data
- Antibody Data
- Antigen structure
- References [202]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
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Validation data
Reference
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- Product number
- 14088-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14088-1-AP, RRID:AB_2255217
- Product name
- SREBF1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SREBF1 antibody (Cat. #14088-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Toosendanin induces hepatotoxicity via disrupting LXRα/Lipin1/SREBP1 mediated lipid metabolism.
Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes.
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma.
RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid.
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis.
Stigmasterol Activates the mTOR Signaling Pathway by Inhibiting ORP5 Ubiquitination to Promote Milk Synthesis in Bovine Mammary Epithelial Cells.
Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease.
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
DNAJA1 positively regulates amino acid-stimulated milk protein and fat synthesis in bovine mammary epithelial cells.
Valine promotes milk synthesis by regulating PKM2 nuclear accumulation and histone H3 acetylation through the TAS1R1-mTOR-DDX39B signaling pathway.
6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway.
Si-Ni-San inhibits hepatic Fasn expression and lipid accumulation in MAFLD mice through AMPK/p300/SREBP-1c axis.
NAMPT promotes the malignant progression of HBV-associated hepatocellular carcinoma through activation of SREBP1-mediated lipogenesis.
Stigmasterol and gastrodin, two major components of banxia-baizhu-tianma decoction, alleviated the excessive phlegm-dampness hypertension by reducing lipid accumulation.
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Acylated Ghrelin Activates PI3K/mTOR Signaling Pathway by Promoting ThPOK Acetylation to Promote Milk Fat Synthesis in Bovine Mammary Epithelial Cells.
Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate.
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
Comprehensive Analysis of Transcriptome and Metabolome Reveals Regulatory Mechanism of Intramuscular Fat Content in Beef Cattle.
PEDV inhibits HNRNPA3 expression by miR-218-5p to enhance cellular lipid accumulation and promote viral replication.
Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice.
A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy.
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis.
PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8(+)T cells.
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway.
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Hepatotoxicity induced in rats by chronic exposure to F-53B, an emerging replacement of perfluorooctane sulfonate (PFOS).
Bufalin Inhibits Tumorigenesis and SREBP-1-Mediated Lipogenesis in Hepatocellular Carcinoma via Modulating the ATP1A1/CA2 Axis.
The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity.
Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice.
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
Double-edged effect of sodium citrate in Nile tilapia (Oreochromis niloticus): Promoting lipid and protein deposition vs. causing hyperglycemia and insulin resistance.
High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression.
Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2.
Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.
In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages.
Withdrawal.
Photochemistry and photobiology 2023 Nov-Dec;99(6):1501
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis.
ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells.
Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection.
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma.
Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation.
ARID3A plays a key regulatory role in palmitic acid-stimulated milk fat synthesis in mouse mammary epithelial cells.
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis.
ORP5 promotes migration and invasion of cervical cancer cells by inhibiting endoplasmic reticulum stress.
Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway.
Sclareol ameliorates liver injury by inhibiting nuclear factor-kappa B/NOD-like receptor protein 3-mediated inflammation and lipid metabolism disorder in diabetic mice.
Goat FADS2 controlling fatty acid metabolism is directly regulated by SREBP1 in mammary epithelial cells.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes.
Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway.
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
miR-33a Inhibits the Differentiation of Bovine Preadipocytes through the IRS2-Akt Pathway.
Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells.
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
3D artificial sebocyte glands from inertial focusing effect for facile and flexible analysis of light damage and drug screening.
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway.
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
DAXX drives de novo lipogenesis and contributes to tumorigenesis.
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Roxadustat, a Hypoxia-Inducible Factor 1α Activator, Attenuates Both Long- and Short-Term Alcohol-Induced Alcoholic Liver Disease.
Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway.
The interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis.
Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.
GPRC6A is a key mediator of palmitic acid regulation of lipid synthesis in bovine mammary epithelial cells.
SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs.
Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma.
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling.
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
METTL3 is a key regulator of milk synthesis in mammary epithelial cells.
Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).
The lncRNA ZFAS1 regulates lipogenesis in colorectal cancer by binding polyadenylate-binding protein 2 to stabilize SREBP1 mRNA.
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway.
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
Divergent transcriptional regulation of astrocyte reactivity across disorders.
Amelioration action of gastrodigenin rhamno-pyranoside from Moringa seeds on non-alcoholic fatty liver disease.
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis.
A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD.
Elevated thyroid hormones caused by high concentrate diets participate in hepatic metabolic disorders in dairy cows.
Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.
Redox-Unlockable Nanoparticle-Based MST1 Delivery System to Attenuate Hepatic Steatosis via the AMPK/SREBP-1c Signaling Axis.
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Stearic Acid Activates the PI3K-mTOR-4EBP1/S6K and mTOR-SREBP-1 Signaling Axes through FATP4-CDK1 To Promote Milk Synthesis in Primary Bovine Mammary Epithelial Cells.
Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression.
SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation.
L-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice.
L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway.
The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes.
BRG1 Links TLR4 Trans-Activation to LPS-Induced SREBP1a Expression and Liver Injury.
An Integrated Transcriptomics and Proteomics Analysis Implicates lncRNA MALAT1 in the Regulation of Lipid Metabolism.
Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice.
JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathway.
UFL1 regulates milk protein and fat synthesis-related gene expression of bovine mammary epithelial cells probably via the mTOR signaling pathway.
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice.
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer.
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice.
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.
Compound C enhances the anticancer effect of aspirin in HER-2-positive breast cancer by regulating lipid metabolism in an AMPK-independent pathway.
Delivery of microRNA-33 Antagomirs by Mesoporous Silica Nanoparticles to Ameliorate Lipid Metabolic Disorders.
Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer.
SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β-catenin signaling pathway.
Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress.
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy.
Viburnum opulus L. Juice Phenolics Inhibit Mouse 3T3-L1 Cells Adipogenesis and Pancreatic Lipase Activity.
Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes.
Sesamol Alleviates Obesity-Related Hepatic Steatosis via Activating Hepatic PKA Pathway.
A metastasis map of human cancer cell lines.
ZHX2 inhibits SREBP1c-mediated de novo lipogenesis in hepatocellular carcinoma via miR-24-3p.
Exosomal miR-199a-5p promotes hepatic lipid accumulation by modulating MST1 expression and fatty acid metabolism.
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
GRP78 regulates milk biosynthesis and the proliferation of bovinemammaryepithelial cells through the mTOR signaling pathway.
MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway.
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
NUCKS1 is a novel regulator of milk synthesis in and proliferation of mammary epithelial cells via the mTOR signaling pathway.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.
Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes.
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
U2AF65 enhances milk synthesis and growth of bovine mammary epithelial cells by positively regulating the mTOR-SREBP-1c signalling pathway.
Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha.
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells.
microRNA-16-5p promotes 3T3-L1 adipocyte differentiation through regulating EPT1.
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Fibronectin type III domain-containing protein 5 promotes proliferation and differentiation of goat adipose-derived stem cells.
Cyclase-associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells.
Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor α Activation.
Downregulation of microRNA-1 attenuates glucose-induced apoptosis by regulating the liver X receptor α in cardiomyocytes.
NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression.
CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.
Mitochondrial ATAD3A regulates milk biosynthesis and proliferation of mammary epithelial cells from dairy cow via the mTOR pathway.
Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway.
MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study.
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.
DEAD-box helicase 6 (DDX6) is a new negative regulator for milk synthesis and proliferation of bovine mammary epithelial cells.
Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice.
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis.
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout.
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Chronic dexamethasone exposure markedly decreased the hepatic triglyceride accumulation in growing goats.
Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway.
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.
Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner.
Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis.
Sodium sulfite promotes the assembly and secretion of very low-density lipoprotein in HL-7702 hepatocytes.
Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice.
MicroRNA-24 promotes 3T3-L1 adipocyte differentiation by directly targeting the MAPK7 signaling.
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer.
Supplementation of chitosan alleviates high-fat diet-enhanced lipogenesis in rats via adenosine monophosphate (AMP)-activated protein kinase activation and inhibition of lipogenesis-associated genes.
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction.
LXRalpha gene downregulation by lentiviral-based RNA interference enhances liver function after fatty liver transplantation in rats.
Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.
Pleiotropic effects of cavin-1 deficiency on lipid metabolism.
A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62.
Chen S, Ni J, Luo L, Lin J, Peng H, Shen F, Huang Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114631
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114631
Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes.
Zhu L, Shi Y, Feng Z, Yuan D, Guo S, Wang Y, Shen H, Li Y, Yan F, Wang Y
European journal of pharmacology 2024 May 15;971:176519
European journal of pharmacology 2024 May 15;971:176519
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
Zhang X, Xu Y, Li S, Qin Y, Zhu G, Zhang Q, Zhang Y, Guan F, Fan T, Liu H
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma.
Yang P, Li H, Sun M, Guo X, Liao Y, Hu M, Ye P, Liu R
Free radical biology & medicine 2024 Mar;213:512-522
Free radical biology & medicine 2024 Mar;213:512-522
RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid.
Yu Y, Xu Z, Zhou H, Xu R, Xu J, Liu W, Wu Y, Qiu Y, Zhang G, Huang X, Chen Y
Cancer cell international 2024 Mar 29;24(1):118
Cancer cell international 2024 Mar 29;24(1):118
Integrating transcriptomics and network pharmacology to reveal the mechanisms of total Rhizoma Coptidis alkaloids against nonalcoholic steatohepatitis.
Li J, Ma Z, Yang Z, Yang M, Li C, Li M, Li X, Chen X, Ma H, Chen W, Ye X, Li X
Journal of ethnopharmacology 2024 Mar 25;322:117600
Journal of ethnopharmacology 2024 Mar 25;322:117600
SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis.
Wang Y, Zhao Z, Guo T, Wu T, Zhang M, Luo D, Dou K, Yang Y, Jin C, Zhang B, Zhang B, Han B
NPJ precision oncology 2024 Mar 1;8(1):58
NPJ precision oncology 2024 Mar 1;8(1):58
Stigmasterol Activates the mTOR Signaling Pathway by Inhibiting ORP5 Ubiquitination to Promote Milk Synthesis in Bovine Mammary Epithelial Cells.
Sun M, Cao Y, Cheng J, Xu D, Li F, Wang J, Ge Y, Liu Y, Long X, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 Jul 3;72(26):14769-14785
Journal of agricultural and food chemistry 2024 Jul 3;72(26):14769-14785
Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease.
Zhou M, Liu X, Wu Y, Xiang Q, Yu R
Journal of ethnopharmacology 2024 Jul 15;329:118160
Journal of ethnopharmacology 2024 Jul 15;329:118160
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Yang J, Zhang Z, Du X, Wang Y, Meng R, Ge K, Wu C, Liang X, Zhang H, Guo H
Environmental research 2024 Jul 1;252(Pt 4):119113
Environmental research 2024 Jul 1;252(Pt 4):119113
DNAJA1 positively regulates amino acid-stimulated milk protein and fat synthesis in bovine mammary epithelial cells.
Li Z, Yuan X, Wang Y, Sun Z, Ao J
Cell biochemistry and function 2024 Jan;42(1):e3918
Cell biochemistry and function 2024 Jan;42(1):e3918
Valine promotes milk synthesis by regulating PKM2 nuclear accumulation and histone H3 acetylation through the TAS1R1-mTOR-DDX39B signaling pathway.
Cao Y, Hu G, Long X, Li F, Wang J, Sun M, Xie Y, Ge Y, Guo W, Liu J, Fu S
International journal of biological macromolecules 2024 Jan;254(Pt 3):127786
International journal of biological macromolecules 2024 Jan;254(Pt 3):127786
6-Gingerol regulates triglyceride and cholesterol biosynthesis to improve hepatic steatosis in MAFLD by activating the AMPK-SREBPs signaling pathway.
Xia Q, Lu F, Chen Y, Li J, Huang Z, Fang K, Hu M, Guo Y, Dong H, Xu L, Gong J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116060
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116060
Si-Ni-San inhibits hepatic Fasn expression and lipid accumulation in MAFLD mice through AMPK/p300/SREBP-1c axis.
Lan T, Geng XJ, Zhang SJ, Zeng XX, Ying JJ, Xu Y, Liu SY, Li P, Tong YH, Wang W, Mao ZJ, Wang SW
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155209
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155209
NAMPT promotes the malignant progression of HBV-associated hepatocellular carcinoma through activation of SREBP1-mediated lipogenesis.
He XL, Guo HJ, Lei YR, Li J, Li JY, Li MH, Li N, Wang F, Mo CF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23444
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23444
Stigmasterol and gastrodin, two major components of banxia-baizhu-tianma decoction, alleviated the excessive phlegm-dampness hypertension by reducing lipid accumulation.
Zhang H, Sun Y, Zou Y, Chen C, Wang S
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117193
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117193
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Huang C, Zhang Y, Xu Y, Wei S, Yang T, Wang S, Li C, Lin H, Li X, Zhao S, Zhu L, Pan W
Aging 2024 Jan 26;16(3):2362-2384
Aging 2024 Jan 26;16(3):2362-2384
Acylated Ghrelin Activates PI3K/mTOR Signaling Pathway by Promoting ThPOK Acetylation to Promote Milk Fat Synthesis in Bovine Mammary Epithelial Cells.
Wang J, Cao Y, Long X, Li F, Jiang N, Sun M, Xie Y, Ge Y, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 Jan 10;72(1):390-404
Journal of agricultural and food chemistry 2024 Jan 10;72(1):390-404
Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate.
Deng R, Zheng Z, Hu S, Wang M, Feng J, Mattjus P, Zhang Z, Zhang Y
Biochimica et biophysica acta. Molecular cell research 2024 Feb;1871(2):119644
Biochimica et biophysica acta. Molecular cell research 2024 Feb;1871(2):119644
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
Xu S, Kong L, Li L, Wang C, Gu J, Luo H, Meng Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
Comprehensive Analysis of Transcriptome and Metabolome Reveals Regulatory Mechanism of Intramuscular Fat Content in Beef Cattle.
Yu H, Yu S, Guo J, Wang J, Mei C, Abbas Raza SH, Cheng G, Zan L
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2911-2924
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2911-2924
PEDV inhibits HNRNPA3 expression by miR-218-5p to enhance cellular lipid accumulation and promote viral replication.
Shi X, Zhang Q, Yang N, Wang Q, Zhang Y, Xu X
mBio 2024 Feb 14;15(2):e0319723
mBio 2024 Feb 14;15(2):e0319723
Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice.
Tong D, Xiang J, Liu W, Sun F, Wang L, Mou A, Cao T, Zhou Q, You M, Liao Y, Gao P, Liu D, Lu Z, Zhu Z
Diabetology & metabolic syndrome 2024 Feb 1;16(1):33
Diabetology & metabolic syndrome 2024 Feb 1;16(1):33
A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy.
Liu J, Xu D, Yan J, Wang B, Zhang L, Liu X, Zhang H, Yan G, Yang J, Zeng Q, Wang X
Photodiagnosis and photodynamic therapy 2024 Aug;48:104238
Photodiagnosis and photodynamic therapy 2024 Aug;48:104238
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Yue C, Lu W, Fan S, Huang Z, Yang J, Dong H, Zhang X, Shang Y, Lai W, Li D, Dong T, Yuan A, Wu J, Kang L, Hu Y
Nature nanotechnology 2024 Aug;19(8):1203-1215
Nature nanotechnology 2024 Aug;19(8):1203-1215
Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis.
Wu C, Li J, Jia H, Zhao J, Qin M, Shi H, Liu C, Lin J, Cai M, Gu Y, Liu B, Gao L
Journal of gastroenterology 2024 Apr;59(4):342-356
Journal of gastroenterology 2024 Apr;59(4):342-356
PI3K/AKT mediated De novo fatty acid synthesis regulates RIG-1/MDA-5-dependent type I IFN responses in BVDV-infected CD8(+)T cells.
Liu SS, Bai TT, Que TL, Luo A, Liang YX, Song YX, Liu TY, Chen JW, Li J, Li N, Zhang ZC, Chen NN, Liu Y, Zhang ZC, Zhou YL, Wang X, Zhu ZB
Veterinary microbiology 2024 Apr;291:110034
Veterinary microbiology 2024 Apr;291:110034
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Lin S, Wang L, Jia Y, Sun Y, Qiao P, Quan Y, Liu J, Hu H, Yang B, Zhou H
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway.
Deng R, Zhu Y, Liu K, Zhang Q, Hu S, Wang M, Zhang Y
Bioorganic chemistry 2024 Apr;145:107212
Bioorganic chemistry 2024 Apr;145:107212
Sodium butyrate alleviates free fatty acid-induced steatosis in primary chicken hepatocytes via the AMPK/PPARα pathway.
Ding J, Liu J, Chen J, Cheng X, Cao H, Guo X, Hu G, Zhuang Y
Poultry science 2024 Apr;103(4):103482
Poultry science 2024 Apr;103(4):103482
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429
Communications biology 2024 Apr 9;7(1):429
Hepatotoxicity induced in rats by chronic exposure to F-53B, an emerging replacement of perfluorooctane sulfonate (PFOS).
Li X, Zhang Q, Wang A, Shan S, Wang X, Wang Y, Wan J, Ning P, Hong C, Tian H, Zhao Y
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123544
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123544
Bufalin Inhibits Tumorigenesis and SREBP-1-Mediated Lipogenesis in Hepatocellular Carcinoma via Modulating the ATP1A1/CA2 Axis.
Huang CJ, Zhang CY, Zhao YK, Wang D, Zhuang L, Qian L, Xie L, Zhu Y, Meng ZQ
The American journal of Chinese medicine 2023;51(2):461-485
The American journal of Chinese medicine 2023;51(2):461-485
The Chinese herbal medicine Dai-Zong-Fang promotes browning of white adipocytes in vivo and in vitro by activating PKA pathway to ameliorate obesity.
Xu J, Zhang LW, Feng H, Tang Y, Fu SQ, Liu XM, Zhu XY
Frontiers in pharmacology 2023;14:1176443
Frontiers in pharmacology 2023;14:1176443
Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice.
Wang P, Li R, Li Y, Tan S, Jiang J, Liu H, Wei X
Gastroenterology report 2023;11:goad032
Gastroenterology report 2023;11:goad032
PM(2.5) exposure aggravates kidney damage by facilitating the lipid metabolism disorder in diabetic mice.
Jiang Y, Peng Y, Yang X, Yu J, Yu F, Yuan J, Zha Y
PeerJ 2023;11:e15856
PeerJ 2023;11:e15856
Double-edged effect of sodium citrate in Nile tilapia (Oreochromis niloticus): Promoting lipid and protein deposition vs. causing hyperglycemia and insulin resistance.
Wang JX, Qiao F, Zhang ML, Chen LQ, Du ZY, Luo Y
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Sep;14:303-314
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2023 Sep;14:303-314
High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression.
Stahl F, Schmitt I, Denner P, de Boni L, Wüllner U, Breuer P
Scientific reports 2023 Sep 9;13(1):14911
Scientific reports 2023 Sep 9;13(1):14911
Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2.
Wang S, Zhou Y, Yu R, Ling J, Li B, Yang C, Cheng Z, Qian R, Lin Z, Yu C, Zheng J, Zheng X, Jia Q, Wu W, Wu Q, Chen M, Yuan S, Dong W, Shi Y, Jansen R, Yang C, Hao Y, Yao M, Qin W, Jin H
JHEP reports : innovation in hepatology 2023 Oct;5(10):100843
JHEP reports : innovation in hepatology 2023 Oct;5(10):100843
Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer.
Li T, Liu X, Long X, Li Y, Xiang J, Lv Y, Zhao X, Shi S, Chen W
Environmental toxicology 2023 Oct;38(10):2352-2360
Environmental toxicology 2023 Oct;38(10):2352-2360
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Inhibition of the SREBP pathway prevents SARS-CoV-2 replication and inflammasome activation.
Soares VC, Dias SSG, Santos JC, Azevedo-Quintanilha IG, Moreira IBG, Sacramento CQ, Fintelman-Rodrigues N, Temerozo JR, da Silva MAN, Barreto-Vieira DF, Souza TM, Bozza PT
Life science alliance 2023 Nov;6(11)
Life science alliance 2023 Nov;6(11)
In vitro acne disease model from inertial focusing effect for studying the interactions between sebocyte glands and macrophages.
Tang T, Xu Y, Wang L, Zhang P
Biotechnology journal 2023 Nov;18(11):e2300108
Biotechnology journal 2023 Nov;18(11):e2300108
Withdrawal.
Photochemistry and photobiology 2023 Nov-Dec;99(6):1501
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Lin Y, Yang M, Huang L, Yang F, Fan J, Qiang Y, Chang Y, Zhou W, Yan L, Xiong J, Ping J, Chen S, Men D, Li F
Cell reports 2023 Nov 28;42(11):113453
Cell reports 2023 Nov 28;42(11):113453
Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
Zhang M, Ma Z, Qi H, Cui X, Li R, Gao X
The British journal of nutrition 2023 Nov 28;130(10):1665-1677
The British journal of nutrition 2023 Nov 28;130(10):1665-1677
TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway.
Lin L, Li X, Wu AJ, Xiu JB, Gan YZ, Yang XM, Ai ZH
iScience 2023 Nov 17;26(11):108226
iScience 2023 Nov 17;26(11):108226
ACSL4: a double-edged sword target in multiple myeloma, promotes cell proliferation and sensitizes cell to ferroptosis.
Zhang J, Liu Y, Li Q, Zuo L, Zhang B, Zhao F, Fan F, Luo S, Hu Y, Sun C
Carcinogenesis 2023 May 27;44(3):242-251
Carcinogenesis 2023 May 27;44(3):242-251
ASS1-Mediated Reductive Carboxylation of Cytosolic Glutamine Confers Ferroptosis Resistance in Cancer Cells.
Hu Q, Dai J, Zhang Z, Yu H, Zhang J, Zhu X, Qin Y, Zhang L, Zhang P
Cancer research 2023 May 15;83(10):1646-1665
Cancer research 2023 May 15;83(10):1646-1665
Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection.
Doppler C, Messner B, Mimler T, Schachner B, Rezk M, Ganhör C, Wechselberger C, Müller M, Puh S, Pröll J, Arbeithuber B, Müller T, Zierer A, Bernhard D
Journal of lipid research 2023 Mar;64(3):100338
Journal of lipid research 2023 Mar;64(3):100338
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR-7/m-TOR/SREBP1 pathway on prostate cancer.
Xu W, Ding J, Li B, Sun T, You X, He Q, Sheng W
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
BioFactors (Oxford, England) 2023 Mar;49(2):438-456
Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma.
Zhang L, Li XM, Shi XH, Ye K, Fu XL, Wang X, Guo SM, Ma JQ, Xu FF, Sun HM, Li QQ, Zhang WY, Ye LH
Acta pharmacologica Sinica 2023 Mar;44(3):622-634
Acta pharmacologica Sinica 2023 Mar;44(3):622-634
Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation.
Wang D, Zhang M, Xu J, Yang J
Molecules (Basel, Switzerland) 2023 Mar 31;28(7)
Molecules (Basel, Switzerland) 2023 Mar 31;28(7)
ARID3A plays a key regulatory role in palmitic acid-stimulated milk fat synthesis in mouse mammary epithelial cells.
Guo X, Qi H, Lin G, Yu J, Zhang M, Gao X
Cell biology international 2023 Jun;47(6):1106-1117
Cell biology international 2023 Jun;47(6):1106-1117
Docosahexaenoic Acid Alters Lipid Metabolism Processes via H3K9ac Epigenetic Modification in Dairy Goat.
Wu J, Luo J, He Q, Xia Y, Tian H, Zhu L, Li C, Loor JJ
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
Journal of agricultural and food chemistry 2023 Jun 7;71(22):8527-8539
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis.
Yang F, Wu Y, Chen Y, Xi J, Chu Y, Jin J, Yan Y
JHEP reports : innovation in hepatology 2023 Jul;5(7):100746
JHEP reports : innovation in hepatology 2023 Jul;5(7):100746
ORP5 promotes migration and invasion of cervical cancer cells by inhibiting endoplasmic reticulum stress.
Wu Y, Min L, Zhang P, Zhang L, Xu Y, Li D, Zheng M, Pei D, Wang Q
Cell stress & chaperones 2023 Jul;28(4):395-407
Cell stress & chaperones 2023 Jul;28(4):395-407
Cassiae Semen improves non-alcoholic fatty liver disease through autophagy-related pathway.
Ding M, Zhou F, Li Y, Liu C, Gu Y, Wu J, Fan G, Li Y, Li X
Chinese herbal medicines 2023 Jul;15(3):421-429
Chinese herbal medicines 2023 Jul;15(3):421-429
Sclareol ameliorates liver injury by inhibiting nuclear factor-kappa B/NOD-like receptor protein 3-mediated inflammation and lipid metabolism disorder in diabetic mice.
Tang L, Mei X, Ye M, Liu Y, Huang Y, Yu J, Zhang L, Zhuge S, Jiang G, Zhu J
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223644
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231223644
Goat FADS2 controlling fatty acid metabolism is directly regulated by SREBP1 in mammary epithelial cells.
Wu J, Luo J, Xia Y, An X, Guo P, He Q, Tian H, Hu Q, Li C, Wang H
Journal of animal science 2023 Jan 3;101
Journal of animal science 2023 Jan 3;101
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes.
Du ZQ, Pang YQ, Zhang Y, Wang L, Zhang R, Li H, Yang CX
Poultry science 2023 Feb;102(2):102363
Poultry science 2023 Feb;102(2):102363
Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway.
Lei Z, Ali I, Yang M, Yang C, Li Y, Li L
Antioxidants (Basel, Switzerland) 2023 Feb 9;12(2)
Antioxidants (Basel, Switzerland) 2023 Feb 9;12(2)
The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.
Ganji R, Paulo JA, Xi Y, Kline I, Zhu J, Clemen CS, Weihl CC, Purdy JG, Gygi SP, Raman M
Nature communications 2023 Feb 6;14(1):638
Nature communications 2023 Feb 6;14(1):638
miR-33a Inhibits the Differentiation of Bovine Preadipocytes through the IRS2-Akt Pathway.
Zhang W, Raza SHA, Li B, Sun B, Wang S, Pant SD, Al-Abbas NS, Shaer NA, Zan L
Genes 2023 Feb 20;14(2)
Genes 2023 Feb 20;14(2)
Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism.
Zhang S, You Y, Li Y, Yuan H, Zhou J, Tian L, Liu Y, Wang B, Zhu E
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23266
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23266
Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells.
Qi H, Lin G, Guo S, Guo X, Yu C, Zhang M, Gao X
Animal biotechnology 2023 Dec;34(8):4094-4104
Animal biotechnology 2023 Dec;34(8):4094-4104
Exogenous H(2) S promotes ubiquitin-mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S-sulfhydration.
Zhang S, Wang M, Li H, Li Q, Liu N, Dong S, Zhao Y, Pang K, Huang J, Ren C, Wang Y, Tian Z, Lu F, Zhang W
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2719-2732
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
Duan J, Dong W, Wang G, Xiu W, Pu G, Xu J, Ye C, Zhang X, Zhu Y, Wang C
Nature communications 2023 Dec 9;14(1):8151
Nature communications 2023 Dec 9;14(1):8151
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
La Y, Wong W, Peng K, Tian Z, Pan J, Sun R, Luan J, Yan K, Zhang Q, Zhang Z
Inflammation 2023 Aug;46(4):1575-1586
Inflammation 2023 Aug;46(4):1575-1586
3D artificial sebocyte glands from inertial focusing effect for facile and flexible analysis of light damage and drug screening.
Tang T, Wei Y, Jia H, Wang L, Xu Y, Zhang P
Biotechnology journal 2023 Aug;18(8):e2200634
Biotechnology journal 2023 Aug;18(8):e2200634
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway.
Chen S, Sun S, Feng Y, Li X, Yin G, Liang P, Yu W, Meng D, Zhang X, Liu H, Zhang F
European journal of pharmacology 2023 Aug 5;952:175808
European journal of pharmacology 2023 Aug 5;952:175808
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Zhou X, Li Y, Yang C, Chen D, Wang T, Liu T, Yan W, Su Z, Peng B, Ren X
Life sciences 2023 Aug 15;327:121698
Life sciences 2023 Aug 15;327:121698
DAXX drives de novo lipogenesis and contributes to tumorigenesis.
Mahmud I, Tian G, Wang J, Hutchinson TE, Kim BJ, Awasthee N, Hale S, Meng C, Moore A, Zhao L, Lewis JE, Waddell A, Wu S, Steger JM, Lydon ML, Chait A, Zhao LY, Ding H, Li JL, Purayil HT, Huo Z, Daaka Y, Garrett TJ, Liao D
Nature communications 2023 Apr 12;14(1):1927
Nature communications 2023 Apr 12;14(1):1927
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Gu W, Yang L, Wang X, Geng J, Li X, Zheng K, Guan Y, Hou X, Wang C, Song G
Kidney & blood pressure research 2022;47(8):514-522
Kidney & blood pressure research 2022;47(8):514-522
Roxadustat, a Hypoxia-Inducible Factor 1α Activator, Attenuates Both Long- and Short-Term Alcohol-Induced Alcoholic Liver Disease.
Gao Y, Jiang X, Yang D, Guo W, Wang D, Gong K, Peng Y, Jiang H, Shi C, Duan Y, Chen Y, Han J, Yang X
Frontiers in pharmacology 2022;13:895710
Frontiers in pharmacology 2022;13:895710
Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer.
Chen H, Qi Q, Wu N, Wang Y, Feng Q, Jin R, Jiang L
Redox biology 2022 Sep;55:102426
Redox biology 2022 Sep;55:102426
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
Cheng J, Xu D, Chen L, Guo W, Hu G, Liu J, Fu S
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Wang Y, Wang HL, Lin ZP, Zhong JF, Chen KL, Duan X
Molecular biology reports 2022 Oct;49(10):9297-9305
Molecular biology reports 2022 Oct;49(10):9297-9305
Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway.
Zhou C, Li P, Han M, Gao X
Animal biotechnology 2022 Oct;33(5):851-863
Animal biotechnology 2022 Oct;33(5):851-863
The interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis.
Wang Y, Zhang Y, Wang Z, Yu L, Chen K, Xie Y, Liu Y, Liang W, Zheng Y, Zhan Y, Ding Y
Cell death discovery 2022 Oct 28;8(1):431
Cell death discovery 2022 Oct 28;8(1):431
Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.
Hu S, Feng J, Wang M, Wufuer R, Liu K, Zhang Z, Zhang Y
Redox biology 2022 Nov;57:102470
Redox biology 2022 Nov;57:102470
GPRC6A is a key mediator of palmitic acid regulation of lipid synthesis in bovine mammary epithelial cells.
Jin X, Zhen Z, Wang Z, Gao X, Li M
Cell biology international 2022 Nov;46(11):1747-1758
Cell biology international 2022 Nov;46(11):1747-1758
SIRT4 Expression Ameliorates the Detrimental Effect of Heat Stress via AMPK/mTOR Signaling Pathway in BMECs.
Ding Q, Wang Y, Xia SW, Zhao F, Zhong JF, Wang HL, Chen KL
International journal of molecular sciences 2022 Nov 1;23(21)
International journal of molecular sciences 2022 Nov 1;23(21)
Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma.
Narahara S, Watanabe T, Nagaoka K, Fujimoto N, Furuta Y, Tanaka K, Tokunaga T, Kawasaki T, Yoshimaru Y, Setoyama H, Oniki K, Saruwatari J, Tateyama M, Naoe H, Tanaka M, Tanaka Y, Sasaki Y
Hepatology communications 2022 May;6(5):1198-1212
Hepatology communications 2022 May;6(5):1198-1212
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Li T, Chen Y, Tan P, Shi H, Huang Z, Cai T, Cheng Y, Du Y, Fu W
Bioorganic chemistry 2022 May;122:105737
Bioorganic chemistry 2022 May;122:105737
Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling.
Hao Q, Wang Z, Wang L, Han M, Zhang M, Gao X
The British journal of nutrition 2022 May 20;:1-11
The British journal of nutrition 2022 May 20;:1-11
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
Zhang W, Ho CT, Lu M
International journal of molecular sciences 2022 May 17;23(10)
International journal of molecular sciences 2022 May 17;23(10)
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.
Zeng H, Qin H, Liao M, Zheng E, Luo X, Xiao A, Li Y, Chen L, Wei L, Zhao L, Ruan XZ, Yang P, Chen Y
Molecular metabolism 2022 Mar;57:101428
Molecular metabolism 2022 Mar;57:101428
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Li S, Wang C, Wu Z
Amino acids 2022 Mar;54(3):339-351
Amino acids 2022 Mar;54(3):339-351
METTL3 is a key regulator of milk synthesis in mammary epithelial cells.
Wang L, Qi H, Li D, Liu L, Chen D, Gao X
Cell biology international 2022 Mar;46(3):359-369
Cell biology international 2022 Mar;46(3):359-369
Azithromycin alleviates the severity of rheumatoid arthritis by targeting the unfolded protein response component of glucose-regulated protein 78 (GRP78).
Zhang Y, Ge L, Song G, Zhang R, Li S, Shi H, Zhang H, Li Y, Pan J, Wang L, Han J
British journal of pharmacology 2022 Mar;179(6):1201-1219
British journal of pharmacology 2022 Mar;179(6):1201-1219
The lncRNA ZFAS1 regulates lipogenesis in colorectal cancer by binding polyadenylate-binding protein 2 to stabilize SREBP1 mRNA.
Wang H, Chen Y, Liu Y, Li Q, Luo J, Wang L, Chen Y, Sang C, Zhang W, Ge X, Yao Z, Miao L, Liu X
Molecular therapy. Nucleic acids 2022 Mar 8;27:363-374
Molecular therapy. Nucleic acids 2022 Mar 8;27:363-374
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway.
Gu W, Wang X, Zhao H, Geng J, Li X, Zheng K, Guan Y, Hou X, Wang C, Song G
European journal of pharmacology 2022 Mar 5;918:174776
European journal of pharmacology 2022 Mar 5;918:174776
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Wang Y, Wang Y, Li F, Zou J, Li X, Xu M, Yu D, Ma Y, Huang W, Sun X, Zhang Y
Cells 2022 Mar 22;11(7)
Cells 2022 Mar 22;11(7)
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
Luo M, Ma X, Jiang W, Zhang J, Liu W, Wei S, Liu H
European journal of medicinal chemistry 2022 Mar 15;232:114168
European journal of medicinal chemistry 2022 Mar 15;232:114168
Divergent transcriptional regulation of astrocyte reactivity across disorders.
Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564
Nature 2022 Jun;606(7914):557-564
Amelioration action of gastrodigenin rhamno-pyranoside from Moringa seeds on non-alcoholic fatty liver disease.
Liao M, Sun C, Li R, Li W, Ge Z, Adu-Frimpong M, Xu X, Yu J
Food chemistry 2022 Jun 15;379:132087
Food chemistry 2022 Jun 15;379:132087
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
Song CC, Pantopoulos K, Chen GH, Zhong CC, Zhao T, Zhang DG, Luo Z
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis.
Qi Y, Zhang H, Fan H, Wang X, Zhao A, Tian Y, Yang G, Li C, Wei J, Yao W, Hao C
Environmental pollution (Barking, Essex : 1987) 2022 Jan 1;292(Pt A):118272
Environmental pollution (Barking, Essex : 1987) 2022 Jan 1;292(Pt A):118272
A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD.
Shao Y, Yao Z, Zhou J, Yu M, Chen S, Yuan Y, Han L, Jiang L, Liu J
Nutrition & metabolism 2022 Dec 6;19(1):80
Nutrition & metabolism 2022 Dec 6;19(1):80
Elevated thyroid hormones caused by high concentrate diets participate in hepatic metabolic disorders in dairy cows.
Chen Q, Wu C, Yao Z, Cai L, Ni Y, Mao S
Animal bioscience 2022 Aug;35(8):1184-1194
Animal bioscience 2022 Aug;35(8):1184-1194
Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.
Fang Y, Fang D
Gene 2022 Aug 5;834:146594
Gene 2022 Aug 5;834:146594
Redox-Unlockable Nanoparticle-Based MST1 Delivery System to Attenuate Hepatic Steatosis via the AMPK/SREBP-1c Signaling Axis.
Li Y, Nie JJ, Yang Y, Li J, Li J, Wu X, Liu X, Chen DF, Yang Z, Xu FJ, Yang Y
ACS applied materials & interfaces 2022 Aug 3;14(30):34328-34341
ACS applied materials & interfaces 2022 Aug 3;14(30):34328-34341
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Journal of genetics and genomics = Yi chuan xue bao 2022 Apr;49(4):364-376
Stearic Acid Activates the PI3K-mTOR-4EBP1/S6K and mTOR-SREBP-1 Signaling Axes through FATP4-CDK1 To Promote Milk Synthesis in Primary Bovine Mammary Epithelial Cells.
Li F, Hu G, Long X, Cao Y, Li Q, Guo W, Wang J, Liu J, Fu S
Journal of agricultural and food chemistry 2022 Apr 6;70(13):4007-4018
Journal of agricultural and food chemistry 2022 Apr 6;70(13):4007-4018
Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression.
Jin Y, Tan Y, Zhao P, Guo Y, Chen S, Wu J, Ren Z
Communications biology 2022 Apr 6;5(1):326
Communications biology 2022 Apr 6;5(1):326
SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation.
Yuan Y, Zhou D, Chen F, Yang Z, Gu W, Zhang K
Cell death & disease 2022 Apr 6;13(4):312
Cell death & disease 2022 Apr 6;13(4):312
L-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice.
Wang Y, Zhao J, Li Q, Liu J, Sun Y, Zhang K, Fan M, Qian H, Li Y, Wang L
Nutrition & metabolism 2022 Apr 15;19(1):30
Nutrition & metabolism 2022 Apr 15;19(1):30
L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway.
Liang J, Gu L, Liu X, Yan X, Bi X, Fan X, Zhou J, Lu S, Luo L, Yin Z
Nutrition & metabolism 2022 Apr 15;19(1):29
Nutrition & metabolism 2022 Apr 15;19(1):29
The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes.
Kong M, Zhu Y, Shao J, Fan Z, Xu Y
Frontiers in cell and developmental biology 2021;9:622866
Frontiers in cell and developmental biology 2021;9:622866
BRG1 Links TLR4 Trans-Activation to LPS-Induced SREBP1a Expression and Liver Injury.
Dong W, Zhu Y, Zhang Y, Fan Z, Zhang Z, Fan X, Xu Y
Frontiers in cell and developmental biology 2021;9:617073
Frontiers in cell and developmental biology 2021;9:617073
An Integrated Transcriptomics and Proteomics Analysis Implicates lncRNA MALAT1 in the Regulation of Lipid Metabolism.
Wang H, Zhang Y, Guan X, Li X, Zhao Z, Gao Y, Zhang X, Chen R
Molecular & cellular proteomics : MCP 2021;20:100141
Molecular & cellular proteomics : MCP 2021;20:100141
Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice.
Li H, Sheng J, Wang J, Gao H, Yu J, Ding G, Ding N, He W, Zha J
Drug design, development and therapy 2021;15:2309-2324
Drug design, development and therapy 2021;15:2309-2324
JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.
Wang K, Cui Y, Lin P, Yao Z, Sun Y
Frontiers in endocrinology 2021;12:689845
Frontiers in endocrinology 2021;12:689845
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Meng H, Shen M, Li J, Zhang R, Li X, Zhao L, Huang G, Liu J
European journal of pharmacology 2021 Sep 5;906:174280
European journal of pharmacology 2021 Sep 5;906:174280
LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.
Guo S, Zhang Y, Wang S, Yang T, Ma B, Li X, Zhang Y, Jiang X
Toxicology letters 2021 Sep 15;348:50-58
Toxicology letters 2021 Sep 15;348:50-58
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
Tao M, Luo J, Gu T, Yu X, Song Z, Jun Y, Gu H, Han K, Huang X, Yu W, Sun S, Zhang Z, Liu L, Chen X, Zhang L, Luo C, Wang Q
Cell death & disease 2021 Sep 13;12(9):845
Cell death & disease 2021 Sep 13;12(9):845
The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathway.
Meng Z, Liu X, Li T, Fang T, Cheng Y, Han L, Sun B, Chen L
International immunopharmacology 2021 May;94:107492
International immunopharmacology 2021 May;94:107492
UFL1 regulates milk protein and fat synthesis-related gene expression of bovine mammary epithelial cells probably via the mTOR signaling pathway.
Li C, Li L, Ali I, Kuang M, Wang X, Wang G
In vitro cellular & developmental biology. Animal 2021 May;57(5):550-559
In vitro cellular & developmental biology. Animal 2021 May;57(5):550-559
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
Wang D, Yin Z, Ma L, Han L, Chen Y, Pan W, Gong K, Gao Y, Yang X, Chen Y, Han J, Duan Y
Food & function 2021 Jun 7;12(11):4842-4854
Food & function 2021 Jun 7;12(11):4842-4854
A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice.
Li X, Yang L, Li J, Lin L, Zheng G
Food & function 2021 Jul 5;12(13):5862-5875
Food & function 2021 Jul 5;12(13):5862-5875
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer.
Li LY, Yang Q, Jiang YY, Yang W, Jiang Y, Li X, Hazawa M, Zhou B, Huang GW, Xu XE, Gery S, Zhang Y, Ding LW, Ho AS, Zumsteg ZS, Wang MR, Fullwood MJ, Freedland SJ, Meltzer SJ, Xu LY, Li EM, Koeffler HP, Lin DC
Nature communications 2021 Jul 16;12(1):4362
Nature communications 2021 Jul 16;12(1):4362
Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.
Luo N, Yang C, Zhu Y, Chen Q, Zhang B
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
Journal of agricultural and food chemistry 2021 Jan 20;69(2):655-667
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Gong X, Li T, Wan R, Sha L
International immunopharmacology 2021 Feb;91:107173
International immunopharmacology 2021 Feb;91:107173
Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice.
Wen F, Shi Z, Liu X, Tan Y, Wei L, Zhu X, Zhang H, Zhu X, Meng X, Ji W, Yang M, Lu Z
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2021 Feb;53(2):132-144
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2021 Feb;53(2):132-144
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Huang D, Xu B, Liu L, Wu L, Zhu Y, Ghanbarpour A, Wang Y, Chen FJ, Lyu J, Hu Y, Kang Y, Zhou W, Wang X, Ding W, Li X, Jiang Z, Chen J, Zhang X, Zhou H, Li JZ, Guo C, Zheng W, Zhang X, Li P, Melia T, Reinisch K, Chen XW
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE(-/-) mice.
Chen W, Zhang X, Xu M, Jiang L, Zhou M, Liu W, Chen Z, Wang Y, Zou Q, Wang L
European journal of nutrition 2021 Apr;60(3):1655-1668
European journal of nutrition 2021 Apr;60(3):1655-1668
Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.
Cao Y, Hu G, Zhang Q, Ma L, Wang J, Li W, Ge Y, Cheng J, Yang Z, Fu S, Liu J
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4093-4100
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4093-4100
Compound C enhances the anticancer effect of aspirin in HER-2-positive breast cancer by regulating lipid metabolism in an AMPK-independent pathway.
Wu Y, Yan B, Xu W, Guo L, Wang Z, Li G, Hou N, Zhang J, Ling R
International journal of biological sciences 2020;16(4):583-597
International journal of biological sciences 2020;16(4):583-597
Delivery of microRNA-33 Antagomirs by Mesoporous Silica Nanoparticles to Ameliorate Lipid Metabolic Disorders.
Tao Y, Xu S, Wang J, Xu L, Zhang C, Chen K, Lian Z, Zhou J, Xie H, Zheng S, Xu X
Frontiers in pharmacology 2020;11:921
Frontiers in pharmacology 2020;11:921
Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer.
Guo S, Ma B, Jiang X, Li X, Jia Y
Frontiers in pharmacology 2020;11:598
Frontiers in pharmacology 2020;11:598
SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β-catenin signaling pathway.
Wang J, Ling R, Zhou Y, Gao X, Yang Y, Mao C, Chen D
Oncology letters 2020 Sep;20(3):2855-2869
Oncology letters 2020 Sep;20(3):2855-2869
Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress.
Peng Y, Yang X, Luo X, Liu C, Cao X, Wang H, Guo L
Biological research 2020 Oct 27;53(1):50
Biological research 2020 Oct 27;53(1):50
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Feng Z, Pang L, Chen S, Pang X, Huang Y, Qiao Q, Wang Y, Vonglorkham S, Huang Q, Lin X, Wei J
International immunopharmacology 2020 Nov;88:107003
International immunopharmacology 2020 Nov;88:107003
Dietary betaine improves egg-laying rate in hens through hypomethylation and glucocorticoid receptor-mediated activation of hepatic lipogenesis-related genes.
Omer NA, Hu Y, Idriss AA, Abobaker H, Hou Z, Yang S, Ma W, Zhao R
Poultry science 2020 Jun;99(6):3121-3132
Poultry science 2020 Jun;99(6):3121-3132
Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy.
He Q, Wang L, Zhao R, Yan F, Sha S, Cui C, Song J, Hu H, Guo X, Yang M, Cui Y, Sun Y, Sun Z, Liu F, Dong M, Hou X, Chen L
Stem cell research & therapy 2020 Jun 8;11(1):223
Stem cell research & therapy 2020 Jun 8;11(1):223
Viburnum opulus L. Juice Phenolics Inhibit Mouse 3T3-L1 Cells Adipogenesis and Pancreatic Lipase Activity.
Zakłos-Szyda M, Pietrzyk N, Szustak M, Podsędek A
Nutrients 2020 Jul 6;12(7)
Nutrients 2020 Jul 6;12(7)
Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes.
Wang H, Cao Y, Shu L, Zhu Y, Peng Q, Ran L, Wu J, Luo Y, Zuo G, Luo J, Zhou L, Shi Q, Weng Y, Huang A, He TC, Fan J
Journal of cellular and molecular medicine 2020 Jan;24(2):1399-1412
Journal of cellular and molecular medicine 2020 Jan;24(2):1399-1412
Sesamol Alleviates Obesity-Related Hepatic Steatosis via Activating Hepatic PKA Pathway.
Xu HY, Yu L, Chen JH, Yang LN, Lin C, Shi XQ, Qin H
Nutrients 2020 Jan 26;12(2)
Nutrients 2020 Jan 26;12(2)
A metastasis map of human cancer cell lines.
Jin X, Demere Z, Nair K, Ali A, Ferraro GB, Natoli T, Deik A, Petronio L, Tang AA, Zhu C, Wang L, Rosenberg D, Mangena V, Roth J, Chung K, Jain RK, Clish CB, Vander Heiden MG, Golub TR
Nature 2020 Dec;588(7837):331-336
Nature 2020 Dec;588(7837):331-336
ZHX2 inhibits SREBP1c-mediated de novo lipogenesis in hepatocellular carcinoma via miR-24-3p.
Yu X, Lin Q, Wu Z, Zhang Y, Wang T, Zhao S, Song X, Chen C, Wang Z, Xu L, Li C, Gao L, Liang X, Yue X, Ma C
The Journal of pathology 2020 Dec;252(4):358-370
The Journal of pathology 2020 Dec;252(4):358-370
Exosomal miR-199a-5p promotes hepatic lipid accumulation by modulating MST1 expression and fatty acid metabolism.
Li Y, Luan Y, Li J, Song H, Li Y, Qi H, Sun B, Zhang P, Wu X, Liu X, Yang Y, Tao W, Cai L, Yang Z, Yang Y
Hepatology international 2020 Dec;14(6):1057-1074
Hepatology international 2020 Dec;14(6):1057-1074
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Zhao Y, Li M, Yao X, Fei Y, Lin Z, Li Z, Cai K, Zhao Y, Luo Z
Cell reports 2020 Dec 8;33(10):108487
Cell reports 2020 Dec 8;33(10):108487
GRP78 regulates milk biosynthesis and the proliferation of bovinemammaryepithelial cells through the mTOR signaling pathway.
Liu Y, Wang X, Zhen Z, Yu Y, Qiu Y, Xiang W
Cellular & molecular biology letters 2019;24:57
Cellular & molecular biology letters 2019;24:57
MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway.
Chao H, Deng L, Xu F, Yu Z, Xu X, Huang J, Zeng T
OncoTargets and therapy 2019;12:3285-3294
OncoTargets and therapy 2019;12:3285-3294
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
Liu G, Kuang S, Cao R, Wang J, Peng Q, Sun C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
NUCKS1 is a novel regulator of milk synthesis in and proliferation of mammary epithelial cells via the mTOR signaling pathway.
Yuan X, Zhang M, Ao J, Zhen Z, Gao X, Li M
Journal of cellular physiology 2019 Sep;234(9):15825-15835
Journal of cellular physiology 2019 Sep;234(9):15825-15835
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.
He W, Xu Y, Ren X, Xiang D, Lei K, Zhang C, Liu D
Digestive diseases and sciences 2019 Nov;64(11):3182-3191
Digestive diseases and sciences 2019 Nov;64(11):3182-3191
Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes.
Wu L, Wang Y, Chi G, Shen B, Tian Y, Li Z, Han L, Zhang Q, Feng H
Journal of cellular physiology 2019 Nov;234(11):19785-19798
Journal of cellular physiology 2019 Nov;234(11):19785-19798
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, Sun M, Chen B, Zhao W, Wang L, Wang H, Moran MS, Haffty BG, Yang Q
Cell death and differentiation 2019 May;26(5):843-859
Cell death and differentiation 2019 May;26(5):843-859
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
Wang Y, Guo D, He J, Song L, Chen H, Zhang Z, Tan N
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
U2AF65 enhances milk synthesis and growth of bovine mammary epithelial cells by positively regulating the mTOR-SREBP-1c signalling pathway.
Yu Y, Zhen Z, Qi H, Yuan X, Gao X, Zhang M
Cell biochemistry and function 2019 Mar;37(2):93-101
Cell biochemistry and function 2019 Mar;37(2):93-101
Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha.
Ren L, Sun D, Zhou X, Yang Y, Huang X, Li Y, Wang C, Li Y
Journal of ethnopharmacology 2019 Mar 25;232:176-187
Journal of ethnopharmacology 2019 Mar 25;232:176-187
Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.
Ran L, Wang X, Mi A, Liu Y, Wu J, Wang H, Guo M, Sun J, Liu B, Li Y, Wang D, Jiang R, Wang N, Gao W, Zeng L, Huang L, Chen X, LeRoith D, Liang B, Li X, Wu Y
iScience 2019 Jun 28;16:106-121
iScience 2019 Jun 28;16:106-121
Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells.
Li X, Li P, Wang L, Zhang M, Gao X
Journal of agricultural and food chemistry 2019 Jun 26;67(25):7005-7015
Journal of agricultural and food chemistry 2019 Jun 26;67(25):7005-7015
microRNA-16-5p promotes 3T3-L1 adipocyte differentiation through regulating EPT1.
Xu J, Zhang L, Shu G, Wang B
Biochemical and biophysical research communications 2019 Jul 5;514(4):1251-1256
Biochemical and biophysical research communications 2019 Jul 5;514(4):1251-1256
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Li Q, Wang Y, Wu S, Zhou Z, Ding X, Shi R, Thorne RF, Zhang XD, Hu W, Wu M
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Fibronectin type III domain-containing protein 5 promotes proliferation and differentiation of goat adipose-derived stem cells.
Dong Y, Zhang S, Tao J, Zhang X, Zhang J, Yang J, Liang H, Liu D, Cang M
Research in veterinary science 2019 Aug;125:351-359
Research in veterinary science 2019 Aug;125:351-359
Cyclase-associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells.
Yuan X, Zhen Z, Zhang M, Yu Y, Gao X, Ao JX
Cell biochemistry and function 2019 Apr;37(3):185-192
Cell biochemistry and function 2019 Apr;37(3):185-192
Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor α Activation.
Tian Y, Feng H, Han L, Wu L, Lv H, Shen B, Li Z, Zhang Q, Liu G
Frontiers in immunology 2018;9:147
Frontiers in immunology 2018;9:147
Downregulation of microRNA-1 attenuates glucose-induced apoptosis by regulating the liver X receptor α in cardiomyocytes.
Cheng Y, Zhao W, Zhang X, Sun L, Yang H, Wang Y, Cao Y, Chu Y, Liu G
Experimental and therapeutic medicine 2018 Sep;16(3):1814-1824
Experimental and therapeutic medicine 2018 Sep;16(3):1814-1824
NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression.
Qin DD, Yang YF, Pu ZQ, Liu D, Yu C, Gao P, Chen JC, Zong C, Zhang YC, Li X, Wang XD, Liu YT
Journal of cellular and molecular medicine 2018 Oct;22(10):4709-4720
Journal of cellular and molecular medicine 2018 Oct;22(10):4709-4720
CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.
Zhang H, Zhang C, Tang H, Gao S, Sun F, Yang Y, Zhou W, Hu Y, Ke C, Wu Y, Ding Z, Guo L, Pei R, Chen X, Sy MS, Zhang B, Li C
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1710-1725
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1710-1725
Mitochondrial ATAD3A regulates milk biosynthesis and proliferation of mammary epithelial cells from dairy cow via the mTOR pathway.
Chen D, Yuan X, Liu L, Zhang M, Qu B, Zhen Z, Gao X
Cell biology international 2018 May;42(5):533-542
Cell biology international 2018 May;42(5):533-542
Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.
Tian S, Li B, Lei P, Yang X, Zhang X, Bao Y, Shan Y
Molecular nutrition & food research 2018 Mar;62(6):e1700737
Molecular nutrition & food research 2018 Mar;62(6):e1700737
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Chen S, Li X, Liu L, Liu C, Han X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway.
Zhang M, Chen D, Zhen Z, Ao J, Yuan X, Gao X
Journal of cellular physiology 2018 Mar;233(3):2464-2475
Journal of cellular physiology 2018 Mar;233(3):2464-2475
MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study.
Yang Y, Jiang H, Xiao L, Yang X
Oncology reports 2018 Jun;39(6):3073-3085
Oncology reports 2018 Jun;39(6):3073-3085
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Qiao X, Li Y, Mai J, Ji X, Li Q
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.
Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB
The Journal of biological chemistry 2018 Jul 20;293(29):11341-11357
The Journal of biological chemistry 2018 Jul 20;293(29):11341-11357
DEAD-box helicase 6 (DDX6) is a new negative regulator for milk synthesis and proliferation of bovine mammary epithelial cells.
Zhen Z, Zhang M, Yuan X, Qu B, Yu Y, Gao X, Qiu Y
In vitro cellular & developmental biology. Animal 2018 Jan;54(1):52-60
In vitro cellular & developmental biology. Animal 2018 Jan;54(1):52-60
Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice.
Zhang J, Zhang H, Deng X, Zhang N, Liu B, Xin S, Li G, Xu K
Life sciences 2018 Jan 1;192:46-54
Life sciences 2018 Jan 1;192:46-54
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Duan X, Meng Q, Wang C, Liu Z, Sun H, Huo X, Sun P, Ma X, Peng J, Liu K
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis.
Zhong H, Chen K, Feng M, Shao W, Wu J, Chen K, Liang T, Liu C
The FEBS journal 2018 Feb;285(3):501-517
The FEBS journal 2018 Feb;285(3):501-517
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout.
Zhang J, Zhao J, Zheng X, Cai K, Mao Q, Xia H
Molecular medicine reports 2018 Feb;17(2):2169-2176
Molecular medicine reports 2018 Feb;17(2):2169-2176
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, Bai F, Sun X, Lin X, Wei J
International immunopharmacology 2018 Dec;65:256-267
International immunopharmacology 2018 Dec;65:256-267
Chronic dexamethasone exposure markedly decreased the hepatic triglyceride accumulation in growing goats.
Chen Q, Niu L, Hua C, Geng Y, Cai L, Tao S, Ni Y, Zhao R
General and comparative endocrinology 2018 Apr 1;259:115-121
General and comparative endocrinology 2018 Apr 1;259:115-121
Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway.
Li L, Liu L, Qu B, Li X, Gao X, Zhang M
Biochemical and biophysical research communications 2017 Oct 21;492(3):289-294
Biochemical and biophysical research communications 2017 Oct 21;492(3):289-294
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Gao Y, Li J, Xu X, Wang S, Yang Y, Zhou J, Zhang L, Zheng F, Li X, Wang B
International journal of obesity (2005) 2017 May;41(5):729-738
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Acta pharmacologica Sinica 2017 Jan;38(1):69-79
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Biochemical and biophysical research communications 2017 Jan 22;482(4):1246-1251
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Environmental toxicology and pharmacology 2017 Dec;56:15-20
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International journal of food sciences and nutrition 2016;67(3):288-97
International journal of food sciences and nutrition 2016;67(3):288-97
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Toxicology reports 2016;3:98-104
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Food & function 2016 Sep 14;7(9):3716-23
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Biochemical and biophysical research communications 2016 May 20;474(1):76-82
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Journal of lipid research 2016 Aug;57(8):1398-411
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The Journal of biological chemistry 2014 Mar 21;289(12):8473-83
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Journal of lipid research 2014 Apr;55(4):681-97
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PloS one 2013;8(6):e66876
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PloS one 2011;6(6):e21078
PloS one 2011;6(6):e21078
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14088-1-AP(SREBF1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SREBF1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SREBF1. This antibody recognizes human antigen. The SREBF1 antibody has been validated for the following applications: ELISA, WB, IP analysis.