Explore
Validate
Learn
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN153469 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse, Rat, Canine, Chicken/Avian, Hamster
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 2A4
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Phytoceuticals in Fenugreek Ameliorate VLDL Overproduction and Insulin Resistance via the Insig Signaling Pathway.
An In Vivo Magnetic Resonance Spectroscopy Study of the Effects of Caloric and Non-Caloric Sweeteners on Liver Lipid Metabolism in Rats.
Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma.
Lack of mitochondria-generated acetyl-CoA by pyruvate dehydrogenase complex downregulates gene expression in the hepatic de novo lipogenic pathway.
Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling.
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease.
Phytosterols protect against diet-induced hypertriglyceridemia in Syrian golden hamsters.
Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice.
Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.
Activation of liver X receptors reduces CFTR-mediated Cl(-) transport in kidney collecting duct cells.
Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver.
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues.
Starvation and feeding a high-carbohydrate, low-fat diet regulate the expression sterol regulatory element-binding protein-1 in chickens.
Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.
Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism.
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes.
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.
Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).
Khound R, Shen J, Song Y, Santra D, Su Q
Molecular nutrition & food research 2018 Mar;62(5)
Molecular nutrition & food research 2018 Mar;62(5)
An In Vivo Magnetic Resonance Spectroscopy Study of the Effects of Caloric and Non-Caloric Sweeteners on Liver Lipid Metabolism in Rats.
Janssens S, Ciapaite J, Wolters JC, van Riel NA, Nicolay K, Prompers JJ
Nutrients 2017 May 10;9(5)
Nutrients 2017 May 10;9(5)
Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma.
Ahmad F, Patrick S, Sheikh T, Sharma V, Pathak P, Malgulwar PB, Kumar A, Joshi SD, Sarkar C, Sen E
Journal of neurochemistry 2017 Dec;143(6):671-683
Journal of neurochemistry 2017 Dec;143(6):671-683
Lack of mitochondria-generated acetyl-CoA by pyruvate dehydrogenase complex downregulates gene expression in the hepatic de novo lipogenic pathway.
Mahmood S, Birkaya B, Rideout TC, Patel MS
American journal of physiology. Endocrinology and metabolism 2016 Jul 1;311(1):E117-27
American journal of physiology. Endocrinology and metabolism 2016 Jul 1;311(1):E117-27
Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling.
Dungan CM, Li J, Williamson DL
Lipids 2016 Aug;51(8):905-12
Lipids 2016 Aug;51(8):905-12
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
Goedeke L, Rotllan N, Canfrán-Duque A, Aranda JF, Ramírez CM, Araldi E, Lin CS, Anderson NN, Wagschal A, de Cabo R, Horton JD, Lasunción MA, Näär AM, Suárez Y, Fernández-Hernando C
Nature medicine 2015 Nov;21(11):1280-9
Nature medicine 2015 Nov;21(11):1280-9
Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease.
Casali BT, Corona AW, Mariani MM, Karlo JC, Ghosal K, Landreth GE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jun 17;35(24):9173-81
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jun 17;35(24):9173-81
Phytosterols protect against diet-induced hypertriglyceridemia in Syrian golden hamsters.
Rideout TC, Ramprasath V, Griffin JD, Browne RW, Harding SV, Jones PJ
Lipids in health and disease 2014 Jan 6;13:5
Lipids in health and disease 2014 Jan 6;13:5
Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice.
Wen S, Jadhav KS, Williamson DL, Rideout TC
Journal of lipids 2013;2013:908048
Journal of lipids 2013;2013:908048
Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.
Pajvani UB, Qiang L, Kangsamaksin T, Kitajewski J, Ginsberg HN, Accili D
Nature medicine 2013 Aug;19(8):1054-60
Nature medicine 2013 Aug;19(8):1054-60
Activation of liver X receptors reduces CFTR-mediated Cl(-) transport in kidney collecting duct cells.
Raksaseri P, Chatsudthipong V, Muanprasat C, Soodvilai S
American journal of physiology. Renal physiology 2013 Aug 15;305(4):F583-91
American journal of physiology. Renal physiology 2013 Aug 15;305(4):F583-91
Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver.
Liu Y, Major AS, Zienkiewicz J, Gabriel CL, Veach RA, Moore DJ, Collins RD, Hawiger J
Journal of the American Heart Association 2013 Apr 5;2(2):e000093
Journal of the American Heart Association 2013 Apr 5;2(2):e000093
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB
Nature 2012 Apr 19;484(7394):333-8
Nature 2012 Apr 19;484(7394):333-8
Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues.
Gosmain Y, Dif N, Berbe V, Loizon E, Rieusset J, Vidal H, Lefai E
Journal of lipid research 2005 Apr;46(4):697-705
Journal of lipid research 2005 Apr;46(4):697-705
Starvation and feeding a high-carbohydrate, low-fat diet regulate the expression sterol regulatory element-binding protein-1 in chickens.
Zhang Y, Hillgartner FB
The Journal of nutrition 2004 Sep;134(9):2205-10
The Journal of nutrition 2004 Sep;134(9):2205-10
Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins.
Demoulin JB, Ericsson J, Kallin A, Rorsman C, Rönnstrand L, Heldin CH
The Journal of biological chemistry 2004 Aug 20;279(34):35392-402
The Journal of biological chemistry 2004 Aug 20;279(34):35392-402
Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism.
Kim HJ, Miyazaki M, Ntambi JM
Journal of lipid research 2002 Oct;43(10):1750-7
Journal of lipid research 2002 Oct;43(10):1750-7
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Yabe D, Brown MS, Goldstein JL
Proceedings of the National Academy of Sciences of the United States of America 2002 Oct 1;99(20):12753-8
Proceedings of the National Academy of Sciences of the United States of America 2002 Oct 1;99(20):12753-8
Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes.
Yin L, Zhang Y, Hillgartner FB
The Journal of biological chemistry 2002 May 31;277(22):19554-65
The Journal of biological chemistry 2002 May 31;277(22):19554-65
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS, Horton JD
The Journal of clinical investigation 1997 Oct 15;100(8):2115-24
The Journal of clinical investigation 1997 Oct 15;100(8):2115-24
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.
Sheng Z, Otani H, Brown MS, Goldstein JL
Proceedings of the National Academy of Sciences of the United States of America 1995 Feb 14;92(4):935-8
Proceedings of the National Academy of Sciences of the United States of America 1995 Feb 14;92(4):935-8
Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).
Sato R, Yang J, Wang X, Evans MJ, Ho YK, Goldstein JL, Brown MS
The Journal of biological chemistry 1994 Jun 24;269(25):17267-73
The Journal of biological chemistry 1994 Jun 24;269(25):17267-73
No comments: Submit comment
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
