Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations [0]
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- Product number
- 66875-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- SREBF1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated SREBF1 antibody (Cat. #66875-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1B6G5
- Vial size
- 20ul, 150ul
Submitted references Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol-Induced Liver Injury by Regulating the FXR/SHP/SREBP-1c Axis.
Qinlian hongqu decoction ameliorates hyperlipidemia via the IRE1-α/IKKB-β/NF-κb signaling pathway: Network pharmacology and experimental validation.
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
Sterol regulatory element binding transcription factor 1 promotes proliferation and migration in head and neck squamous cell carcinoma.
Role of Gltp in Maturation of Oligodendrocytes Under the Regulation of Nkx2.2.
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8.
Schisandrin treatment suppresses the proliferation, migration, invasion, and inflammatory responses of fibroblast-like synoviocytes from rheumatoid arthritis patients and attenuates synovial inflammation and joint destruction in CIA mice.
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity.
SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism.
miR-363-3p/PTEN is involved in the regulation of lipid metabolism by genistein in HepG2 cells via ERβ.
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-κB/NLRP3 Inflammasome Pathway.
High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia (Oreochromis niloticus).
Hydroxytyrosol attenuates ethanol-induced liver injury by ameliorating steatosis, oxidative stress and hepatic inflammation by interfering STAT3/iNOS pathway.
Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stress.
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.
Puerarin Prevents Bisphenol S Induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice.
Weizmannia coagulans JA845 improves atherosclerosis induced by vitamin D3 and high-fat diet in rats through modulating lipid metabolism, oxidative stress, and endothelial vascular injury.
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota.
Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondria.
Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.
Hawk tea prevents high-fat diet-induced obesity in mice by activating the AMPK/ACC/SREBP1c signaling pathways and regulating the gut microbiota.
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease.
LncNONMMUG027912 alleviates lipid accumulation through AMPKα/mTOR/SREBP1C axis in nonalcoholic fatty liver.
ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors.
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.
Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.
Genistein Regulates Lipid Metabolism via Estrogen Receptor β and Its Downstream Signal Akt/mTOR in HepG2 Cells.
CD36 as a Molecular Target of Functional DNA Aptamer NAFLD01 Selected against NAFLD Cells.
Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission.
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
In vitro effects of Triclocarban on adipogenesis in murine preadipocyte and human hepatocyte.
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Transcription factor E2F4 is a positive regulator of milk biosynthesis and proliferation of bovine mammary epithelial cells.
A Novel Regulatory Circuit "C/EBPα/miR-20a-5p/TOB2" Regulates Adipogenesis and Lipogenesis.
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Liu C, Cai T, Cheng Y, Bai J, Li M, Gu B, Huang M, Fu W
Molecular nutrition & food research 2024 Jul;68(14):e2300927
Molecular nutrition & food research 2024 Jul;68(14):e2300927
Qinlian hongqu decoction ameliorates hyperlipidemia via the IRE1-α/IKKB-β/NF-κb signaling pathway: Network pharmacology and experimental validation.
Zhang Y, Guo Z, Wang J, Yue Y, Yang Y, Wen Y, Luo Y, Zhang X
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116856
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116856
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
Ang B, Yang T, Wang Z, Cheng Y, Chen Q, Wang Z, Zeng M, Chen J, He Z
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
Sterol regulatory element binding transcription factor 1 promotes proliferation and migration in head and neck squamous cell carcinoma.
Tan M, Lin X, Chen H, Ye W, Yi J, Li C, Liu J, Su J
PeerJ 2023;11:e15203
PeerJ 2023;11:e15203
Role of Gltp in Maturation of Oligodendrocytes Under the Regulation of Nkx2.2.
Zhang C, Chen Z, Zhang D, Wang X, Qiu M, Tan Z
Molecular neurobiology 2023 Sep;60(9):4897-4908
Molecular neurobiology 2023 Sep;60(9):4897-4908
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8.
Hu Y, Wang S, Wu L, Yang K, Yang F, Yang J, Hu S, Yao Y, Xia X, Liu Y, Peng L, Wan J, Shen C, Xu T
Chinese journal of natural medicines 2023 Sep;21(9):670-681
Chinese journal of natural medicines 2023 Sep;21(9):670-681
Schisandrin treatment suppresses the proliferation, migration, invasion, and inflammatory responses of fibroblast-like synoviocytes from rheumatoid arthritis patients and attenuates synovial inflammation and joint destruction in CIA mice.
Lin W, Liu Y, Zhang S, Xu S, Qiu Q, Wang C, Liu D, Shen C, Xu M, Shi M, Xiao Y, Chen G, Xu H, Liang L
International immunopharmacology 2023 Sep;122:110502
International immunopharmacology 2023 Sep;122:110502
Investigation of the potential ameliorative effects of DHA-enriched phosphatidylserine on bisphenol A-induced murine nephrotoxicity.
Pu Q, Yang F, Zhao R, Jiang S, Tang Y, Han T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114012
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Oct;180:114012
SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism.
Han J, Li S, Wang W, Jiang X, Liu C, Lei L, Li Y, Sheng R, Zhang Y, Wu Y, Zhang J, Zhang Y, Xu Y, Si S
Current issues in molecular biology 2023 Jun 8;45(6):5052-5070
Current issues in molecular biology 2023 Jun 8;45(6):5052-5070
miR-363-3p/PTEN is involved in the regulation of lipid metabolism by genistein in HepG2 cells via ERβ.
Qin H, Song Z, Zhao C, Li S, Ali A, Zheng W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154839
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154839
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Song D, Zhang A, Hu X, Zeng M, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-κB/NLRP3 Inflammasome Pathway.
Zhang F, Wang M, Zha Y, Zhou J, Han J, Zhang S
Nutrients 2023 Jan 1;15(1)
Nutrients 2023 Jan 1;15(1)
High cholesterol intake remodels cholesterol turnover and energy homeostasis in Nile tilapia (Oreochromis niloticus).
Li RX, Chen LY, Limbu SM, Qian YC, Zhou WH, Chen LQ, Luo Y, Qiao F, Zhang ML, Du ZY
Marine life science & technology 2023 Feb;5(1):56-74
Marine life science & technology 2023 Feb;5(1):56-74
Hydroxytyrosol attenuates ethanol-induced liver injury by ameliorating steatosis, oxidative stress and hepatic inflammation by interfering STAT3/iNOS pathway.
Fang X, Cao J, Tao Z, Yang Z, Dai Y, Zhao L
Redox report : communications in free radical research 2023 Dec;28(1):2187564
Redox report : communications in free radical research 2023 Dec;28(1):2187564
Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stress.
Wei L, Luo H, Jin Y, Shu Y, Wen C, Qin T, Yang X, Ma L, Liu Y, You Y, Zhou C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155080
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155080
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Chen H, Ma Y, Qi X, Tian J, Ma Y, Niu T
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Theabrownin of raw and ripened pu-erh tea varies in the alleviation of HFD-induced obesity via the regulation of gut microbiota.
Deng X, Zhang N, Wang Q, Huang Y, Huang Y, Lin Y, Huang M, Zheng F, Xiao M, Ye J
European journal of nutrition 2023 Aug;62(5):2177-2194
European journal of nutrition 2023 Aug;62(5):2177-2194
Puerarin Prevents Bisphenol S Induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice.
Wu ZY, Luo L, Kan YQ, Qin ML, Li HT, He QZ, Zeng HC
Toxics 2023 Aug 26;11(9)
Toxics 2023 Aug 26;11(9)
Weizmannia coagulans JA845 improves atherosclerosis induced by vitamin D3 and high-fat diet in rats through modulating lipid metabolism, oxidative stress, and endothelial vascular injury.
Ma L, Zhao Z, Zhao Y, Gao Y, Zhao L, Li S
Journal of applied microbiology 2023 Aug 1;134(8)
Journal of applied microbiology 2023 Aug 1;134(8)
CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.
Cheng J, Xu D, Chen L, Guo W, Hu G, Liu J, Fu S
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
He H, Deng J, Yang M, An L, Ye X, Li X
Journal of ethnopharmacology 2022 Nov 15;298:115529
Journal of ethnopharmacology 2022 Nov 15;298:115529
Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota.
Yan J, Xue Q, Chen W, Wang K, Peng D, Jiang J, Li P, Du B
Food research international (Ottawa, Ont.) 2022 May;155:111125
Food research international (Ottawa, Ont.) 2022 May;155:111125
Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondria.
Chen L, Li Y, Sottas C, Lazaris A, Petrillo SK, Metrakos P, Li L, Ishida Y, Saito T, Garza S, Papadopoulos V
The Journal of biological chemistry 2022 Jun;298(6):102008
The Journal of biological chemistry 2022 Jun;298(6):102008
Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.
Liu P, Lin C, Liu Z, Zhu C, Lin Z, Xu D, Chen J, Huang Q, Li CY, Hou L, Pan JA, Liu X
Cellular and molecular life sciences : CMLS 2022 Jun 8;79(7):352
Cellular and molecular life sciences : CMLS 2022 Jun 8;79(7):352
Hawk tea prevents high-fat diet-induced obesity in mice by activating the AMPK/ACC/SREBP1c signaling pathways and regulating the gut microbiota.
Tao W, Cao W, Yu B, Chen H, Gong R, Luorong Q, Luo J, Yao L, Zhang D
Food & function 2022 Jun 6;13(11):6056-6071
Food & function 2022 Jun 6;13(11):6056-6071
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Zhang J, Ma X, Fan D
Food & function 2022 Feb 7;13(3):1153-1167
Food & function 2022 Feb 7;13(3):1153-1167
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Gu X, Liu H, Luo W, Wang X, Wang H, Li L
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease.
Lekka E, Kokanovic A, Mosole S, Civenni G, Schmidli S, Laski A, Ghidini A, Iyer P, Berk C, Behera A, Catapano CV, Hall J
Nature communications 2022 Dec 26;13(1):7940
Nature communications 2022 Dec 26;13(1):7940
LncNONMMUG027912 alleviates lipid accumulation through AMPKα/mTOR/SREBP1C axis in nonalcoholic fatty liver.
Chu K, Zhao N, Hu X, Feng R, Zhang L, Wang G, Li W, Liu L
Biochemical and biophysical research communications 2022 Aug 27;618:8-14
Biochemical and biophysical research communications 2022 Aug 27;618:8-14
ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors.
Okuno Y, Fukuhara A, Otsuki M, Shimomura I
JCI insight 2022 Aug 22;7(16)
JCI insight 2022 Aug 22;7(16)
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.
Zhu T, Wang Z, Zou T, Xu L, Zhang S, Chen Y, Chen C, Zhang W, Wang S, Ding Q, Xu G
Frontiers in pharmacology 2021;12:769647
Frontiers in pharmacology 2021;12:769647
Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression.
Cheng L, Yu P, Li F, Jiang X, Jiao X, Shen Y, Lai X
Human cell 2021 Nov;34(6):1697-1708
Human cell 2021 Nov;34(6):1697-1708
Genistein Regulates Lipid Metabolism via Estrogen Receptor β and Its Downstream Signal Akt/mTOR in HepG2 Cells.
Qin H, Song Z, Shaukat H, Zheng W
Nutrients 2021 Nov 10;13(11)
Nutrients 2021 Nov 10;13(11)
CD36 as a Molecular Target of Functional DNA Aptamer NAFLD01 Selected against NAFLD Cells.
Pu Y, Xiang J, Zhang X, Deng Y, Liu H, Tan W
Analytical chemistry 2021 Mar 2;93(8):3951-3958
Analytical chemistry 2021 Mar 2;93(8):3951-3958
Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission.
You YN, Xing QQ, Zhao X, Ji JJ, Yan H, Zhou T, Dong YM, Ren LS, Hou ST, Ding YY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111403
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111403
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Huang D, Xu B, Liu L, Wu L, Zhu Y, Ghanbarpour A, Wang Y, Chen FJ, Lyu J, Hu Y, Kang Y, Zhou W, Wang X, Ding W, Li X, Jiang Z, Chen J, Zhang X, Zhou H, Li JZ, Guo C, Zheng W, Zhang X, Li P, Melia T, Reinisch K, Chen XW
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
Wang C, Song D, Fu J, Wen X
Frontiers in endocrinology 2020;11:580
Frontiers in endocrinology 2020;11:580
In vitro effects of Triclocarban on adipogenesis in murine preadipocyte and human hepatocyte.
Dong M, Yuan P, Song Y, Lei H, Chen G, Zhu X, Wu F, Chen C, Liu C, Shi Z, Zhang L
Journal of hazardous materials 2020 Nov 15;399:122829
Journal of hazardous materials 2020 Nov 15;399:122829
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Dai W, Xu L, Yu X, Zhang G, Guo H, Liu H, Song G, Weng S, Dong L, Zhu J, Liu T, Guo C, Shen X
Journal of hepatology 2020 May;72(5):909-923
Journal of hepatology 2020 May;72(5):909-923
Transcription factor E2F4 is a positive regulator of milk biosynthesis and proliferation of bovine mammary epithelial cells.
Zhen Z, Zhang M, Yuan X, Li M
Cell biology international 2020 Jan;44(1):229-241
Cell biology international 2020 Jan;44(1):229-241
A Novel Regulatory Circuit "C/EBPα/miR-20a-5p/TOB2" Regulates Adipogenesis and Lipogenesis.
Zhou J, Yang J, Wang X, Li M, Li F, Zhu E, Li X, Li X, Wang B
Frontiers in endocrinology 2019;10:894
Frontiers in endocrinology 2019;10:894
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Qiao X, Zhou ZC, Niu R, Su YT, Sun Y, Liu HL, Teng JL, Ye JN, Shi H, Yang CD, Cheng XB
Frontiers in pharmacology 2019;10:855
Frontiers in pharmacology 2019;10:855
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.
Xiao J, Bai XQ, Liao L, Zhou M, Peng J, Xiang Q, Ren Z, Wen HY, Jiang ZS, Tang ZH, Wang MM, Liu LS
International journal of molecular medicine 2019 May;43(5):2055-2063
International journal of molecular medicine 2019 May;43(5):2055-2063
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Duan X, Meng Q, Wang C, Liu Z, Liu Q, Sun H, Sun P, Yang X, Huo X, Peng J, Liu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
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