932201

antibody from BioLegend
Targeting: UBC
Provider product page for 932201
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
932201 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#932201, RRID:AB_2566131
Product name
Purified anti-Polyubiquitin (K63-linkage)
Antibody type
Monoclonal
Antigen
Synthetic peptide containing the ubiquitin K-63 isopeptide motif.
Description
Polymeric or monomeric Ubiquitin exists free (unanchored) or covalently attached to its ligand. Ubiquitin is conjugated to its target via an isopeptide bond either as a monomer or as one of two polymeric forms. Ubiquitin monomers in one type of polymer are covalently linked via various Lys residues (polyubiquitin). The other type of ubiquitin polymer involves monomers that are linked linearly via an initiator Met (linear polyubiquitin). Polyubiquitin’s functions depend on which Lys residue is involved in cross-linking the protein. K63-linked polyubiquitin chains exhibit nonproteolytic function in vivo which includes kinase/phosphatase activation, protein trafficking, endocytosis, DNA-damage responses, as well as in signaling processes which lead to the activation of the transcription factor NF-κ-B.
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
HWA4C4
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
UBC protein structure - 932201 shown in red.