orb2641379

antibody from Biorbyt

Targeting: UBC

Western blot

Immunocytochemistry

Immunohistochemistry

Flow cytometry

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Validation data

Product number: orb2641379 - Provider product page
Provider: Biorbyt
Product name: Ubiquitin Antibody
Antibody type: Monoclonal
Description: Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease etc.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Antibody clone number: UBB/1748
Vial size: 100 ug
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

UBC protein structure - orb2641379 shown in red.