Antibody data
- Antibody Data
- Antigen structure
- References [39]
- Comments [0]
- Validations [0]
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- Product number
- 66294-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- VCAM-1 antibody
- Antibody type
- Monoclonal
- Description
- VCAM-1 antibody (Cat. #66294-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1B12F12
- Vial size
- 20ul, 150ul
Submitted references The GRK2/AP-1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress.
Nitrate-driven maintenance of lipid homeostasis by M2 macrophages alleviates atherosclerosis via downregulation of LOX1 expression and reduction of lipid deposition.
Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis.
Sodium butyrate inhibits activation of ROS/NF-κB/NLRP3 signaling pathway and angiogenesis in human retinal microvascular endothelial cells.
Sustainability of shear stress conditioning in endothelial colony-forming cells compared to human aortic endothelial cells to underline suitability for tissue-engineered vascular grafts.
The methyltransferase METTL3 regulates endothelial cell proliferation and inflammation via m(6)A RNA methylation-mediated TRAF1 expression.
Increased Expression of VCAM1 on Brain Endothelial Cells Drives Blood-Brain Barrier Impairment Following Chronic Cerebral Hypoperfusion.
Immunohistochemistry identifies E-cadherin, N-cadherin and focal adhesion kinase (FAK) as predictors of stage I non-small cell lung carcinoma spread through the air spaces (STAS), and the combinations as prognostic factors.
Integrin α(4) Positive Subpopulation in Adipose Derived Stem Cells Effectively Reduces Infarct Size through Enhanced Engraftment into Myocardial Infarction.
Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis through the HIF1A/EZH2/SF-1 pathway.
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
Novel soybean polypeptide dglycin alleviates atherosclerosis in apolipoprotein E-deficient mice.
Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation.
Blocking VCAM-1 Prevents Angiotensin II-Induced Hypertension and Vascular Remodeling in Mice.
Macrophage-derived exosomal miR-4532 promotes endothelial cells injury by targeting SP1 and NF-κB P65 signalling activation.
Profiling of proteome changes in plasma of HIV-infected patients receiving antiretroviral therapy.
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
The role of AMP-activated protein kinase α1-mediated endoplasmic reticulum stress in alleviating the toxic effect of uremic toxin indoxyl sulfate on vascular endothelial cells by Klotho.
Hypoxic Culture Maintains Cell Growth of the Primary Human Valve Interstitial Cells with Stemness.
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis.
Protection against Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Neferine, A Natural Product from Nelumbo nucifera Gaertn.
Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells.
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Rhodiola crenulata Suppresses High Glucose-Induced Matrix Metalloproteinase Expression and Inflammatory Responses by Inhibiting ROS-Related HMGB1-TLR4 Signaling in Endothelial Cells.
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE(-/-) mice.
Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy.
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Antihypertensive effects of Trichiurus lepturus myosin hydrolysate in spontaneously hypertensive rats.
Antimetastatic Effect of Fucoidan-Sargassum against Liver Cancer Cell Invadopodia Formation via Targeting Integrin αVβ3 and Mediating αVβ3/Src/E2F1 Signaling.
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling.
Long Noncoding RNA HOXA-AS3 Integrates NF-κB Signaling To Regulate Endothelium Inflammation.
Propofol attenuates the adhesion of tumor and endothelial cells through inhibiting glycolysis in human umbilical vein endothelial cells.
LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop.
Metformin ameliorates the progression of atherosclerosis via suppressing macrophage infiltration and inflammatory responses in rabbits.
Tail vein injection of mmLDL upregulates mouse mesenteric artery ET(B) receptors via activation of the ERK1/2 pathway.
Wu LD, Shi Y, Kong CH, Chen AQ, Kang Y, Kan JY, Jiang XM, Chu P, Wang DC, Lv YF, Qian ZY, Jiang ZH, Chen YW, Sun Y, Chang RR, Zhou WY, Gu Y, Zhang JX, Chen SL
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e01981
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e01981
Nitrate-driven maintenance of lipid homeostasis by M2 macrophages alleviates atherosclerosis via downregulation of LOX1 expression and reduction of lipid deposition.
Si Y, Du H, Li S, Zhang C, Wang J, Wang S, Zhou J
Science China. Life sciences 2025 Oct;68(10):2995-3009
Science China. Life sciences 2025 Oct;68(10):2995-3009
Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis.
Dong Z, Jin Y, Shen Y, Huang J, Tan J, Feng Q, Gong Z, Zhu S, Chen H, Yu F, Li W, Jia Y, Kong W, Fu Y
Cardiovascular research 2025 May 6;121(4):568-584
Cardiovascular research 2025 May 6;121(4):568-584
Sodium butyrate inhibits activation of ROS/NF-κB/NLRP3 signaling pathway and angiogenesis in human retinal microvascular endothelial cells.
Cao X, Di Y, Tian YJ, Huang XB, Zhou Y, Zhang DM, Song Y
International ophthalmology 2025 Mar 18;45(1):108
International ophthalmology 2025 Mar 18;45(1):108
Sustainability of shear stress conditioning in endothelial colony-forming cells compared to human aortic endothelial cells to underline suitability for tissue-engineered vascular grafts.
Renzelmann J, Heene S, Jonczyk R, Krüger J, Alnajjar S, Blume C
Microvascular research 2025 Jan;157:104746
Microvascular research 2025 Jan;157:104746
The methyltransferase METTL3 regulates endothelial cell proliferation and inflammation via m(6)A RNA methylation-mediated TRAF1 expression.
Chen D, Xu W, Zheng H, Zhang Y, Lin Y, Han Y, Yao F, Shen H
Biochemical and biophysical research communications 2024 Nov 5;732:150399
Biochemical and biophysical research communications 2024 Nov 5;732:150399
Increased Expression of VCAM1 on Brain Endothelial Cells Drives Blood-Brain Barrier Impairment Following Chronic Cerebral Hypoperfusion.
Zhang H, Shang J, Li W, Gao D, Zhang J
ACS chemical neuroscience 2024 May 15;15(10):2028-2041
ACS chemical neuroscience 2024 May 15;15(10):2028-2041
Immunohistochemistry identifies E-cadherin, N-cadherin and focal adhesion kinase (FAK) as predictors of stage I non-small cell lung carcinoma spread through the air spaces (STAS), and the combinations as prognostic factors.
Meng Y, Wang Y, Liu L, Wu R, Zhang Q, Chen Z, Yao Y, Li X, Gong Y, Li H, Wang Z, Liu H
Translational lung cancer research 2024 Jul 30;13(7):1450-1462
Translational lung cancer research 2024 Jul 30;13(7):1450-1462
Integrin α(4) Positive Subpopulation in Adipose Derived Stem Cells Effectively Reduces Infarct Size through Enhanced Engraftment into Myocardial Infarction.
Yuan Z, Tan J, Wang J
International journal of stem cells 2024 Feb 28;17(1):70-79
International journal of stem cells 2024 Feb 28;17(1):70-79
Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis through the HIF1A/EZH2/SF-1 pathway.
Wu L, Lan D, Sun B, Su R, Pei F, Kuang Z, Su Y, Lin S, Wang X, Zhang S, Chen X, Jia J, Zeng C
Journal of ethnopharmacology 2024 Dec 5;335:118659
Journal of ethnopharmacology 2024 Dec 5;335:118659
Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions.
Shah W, Zhao Q, Wang S, Zhang M, Ma H, Guan Y, Zhang Y, Liu Y, Zhu C, Wang S, Zhang X, Dong J, Ma H
Scientific reports 2023 Oct 2;13(1):16550
Scientific reports 2023 Oct 2;13(1):16550
Novel soybean polypeptide dglycin alleviates atherosclerosis in apolipoprotein E-deficient mice.
Zhao H, Dan P, Xi J, Chen Z, Zhang P, Wei W, Zhao Y
International journal of biological macromolecules 2023 Nov 1;251:126347
International journal of biological macromolecules 2023 Nov 1;251:126347
Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation.
Wang Z, Zhang Z, Li Y, Zhang Y, Wei M, Li H, Yang S, Zhou Y, Zhou X, Xing G
Hypertension research : official journal of the Japanese Society of Hypertension 2023 Jul;46(7):1759-1770
Hypertension research : official journal of the Japanese Society of Hypertension 2023 Jul;46(7):1759-1770
Blocking VCAM-1 Prevents Angiotensin II-Induced Hypertension and Vascular Remodeling in Mice.
Yin L, Bai J, Yu WJ, Liu Y, Li HH, Lin QY
Frontiers in pharmacology 2022;13:825459
Frontiers in pharmacology 2022;13:825459
Macrophage-derived exosomal miR-4532 promotes endothelial cells injury by targeting SP1 and NF-κB P65 signalling activation.
Liu P, Wang S, Wang G, Zhao M, Du F, Li K, Wang L, Wu H, Chen J, Yang Y, Su G
Journal of cellular and molecular medicine 2022 Oct;26(20):5165-5180
Journal of cellular and molecular medicine 2022 Oct;26(20):5165-5180
Profiling of proteome changes in plasma of HIV-infected patients receiving antiretroviral therapy.
Li T, Qu H, Ding H, Deng H, Chen Y
Proteomics. Clinical applications 2022 Nov;16(6):e2100099
Proteomics. Clinical applications 2022 Nov;16(6):e2100099
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Chen Y, Qu L, Li Y, Chen C, He W, Shen L, Zhang R
Inflammation 2022 Feb;45(1):253-266
Inflammation 2022 Feb;45(1):253-266
The role of AMP-activated protein kinase α1-mediated endoplasmic reticulum stress in alleviating the toxic effect of uremic toxin indoxyl sulfate on vascular endothelial cells by Klotho.
Chen C, Wu L, Xie C, Zhao X, Mao H, Xing C
Journal of applied toxicology : JAT 2021 Sep;41(9):1446-1455
Journal of applied toxicology : JAT 2021 Sep;41(9):1446-1455
Hypoxic Culture Maintains Cell Growth of the Primary Human Valve Interstitial Cells with Stemness.
Kanno K, Sakaue T, Hamaguchi M, Namiguchi K, Nanba D, Aono J, Kurata M, Masumoto J, Higashiyama S, Izutani H
International journal of molecular sciences 2021 Sep 29;22(19)
International journal of molecular sciences 2021 Sep 29;22(19)
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
Li Z, Li Q, Wang L, Li C, Xu M, Duan Y, Ma L, Li T, Chen Q, Wang Y, Wang Y, Feng J, Yin X, Wang X, Han J, Lu C
Redox biology 2021 Nov;47:102156
Redox biology 2021 Nov;47:102156
CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis.
Zhang X, Lu J, Zhang Q, Luo Q, Liu B
Biological research 2021 Mar 23;54(1):11
Biological research 2021 Mar 23;54(1):11
Protection against Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Neferine, A Natural Product from Nelumbo nucifera Gaertn.
Min X, Guo Y, Zhou Y, Chen X
Cell journal 2021 Jan;22(4):523-531
Cell journal 2021 Jan;22(4):523-531
Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells.
Liu X, Lu B, Fu J, Zhu X, Song E, Song Y
Journal of hazardous materials 2021 Feb 15;404(Pt B):124050
Journal of hazardous materials 2021 Feb 15;404(Pt B):124050
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Hou JR, Wang YH, Zhong YN, Che TT, Hu Y, Bao J, Meng N
Marine drugs 2021 Dec 18;19(12)
Marine drugs 2021 Dec 18;19(12)
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Ma X, Zhang J, Wu Z, Wang X
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Rhodiola crenulata Suppresses High Glucose-Induced Matrix Metalloproteinase Expression and Inflammatory Responses by Inhibiting ROS-Related HMGB1-TLR4 Signaling in Endothelial Cells.
Huang LY, Yen IC, Tsai WC, Lee SY
The American journal of Chinese medicine 2020;48(1):91-105
The American journal of Chinese medicine 2020;48(1):91-105
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Xie T, Wang C, Jin Y, Meng Q, Liu Q, Wu J, Sun H
Frontiers in pharmacology 2020;11:1034
Frontiers in pharmacology 2020;11:1034
Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE(-/-) mice.
Li T, Safitri M, Zhang K, Wang Y, Huang L, Zhu Y, Daniel R, Wu LJ, Qiu J, Wang G
Atherosclerosis 2020 Oct;310:64-74
Atherosclerosis 2020 Oct;310:64-74
Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy.
Gong C, Yu X, You B, Wu Y, Wang R, Han L, Wang Y, Gao S, Yuan Y
Journal of nanobiotechnology 2020 Jun 16;18(1):92
Journal of nanobiotechnology 2020 Jun 16;18(1):92
Rhamnocitrin extracted from Nervilia fordii inhibited vascular endothelial activation via miR-185/STIM-1/SOCE/NFATc3.
Lin T, Luo W, Li Z, Zhang L, Zheng X, Mai L, Yang W, Guan G, Su Z, Liu P, Li Z, Xie Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Dec;79:153350
Antihypertensive effects of Trichiurus lepturus myosin hydrolysate in spontaneously hypertensive rats.
Fu W, Wang P, Wu H, Zhang Z, Zeng H, Zhang Y, Zheng B, Hu J
Food & function 2020 Apr 30;11(4):3645-3656
Food & function 2020 Apr 30;11(4):3645-3656
Antimetastatic Effect of Fucoidan-Sargassum against Liver Cancer Cell Invadopodia Formation via Targeting Integrin αVβ3 and Mediating αVβ3/Src/E2F1 Signaling.
Pan TJ, Li LX, Zhang JW, Yang ZS, Shi DM, Yang YK, Wu WZ
Journal of Cancer 2019;10(20):4777-4792
Journal of Cancer 2019;10(20):4777-4792
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Zhang L, Wang F, Zhang Q, Liang Q, Wang S, Xian M, Wang F
International journal of molecular sciences 2019 Oct 29;20(21)
International journal of molecular sciences 2019 Oct 29;20(21)
IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling.
Yu J, Ming H, Li HY, Yu B, Chu M, Zhu H, Zhu X
Toxicology and applied pharmacology 2019 Oct 15;381:114732
Toxicology and applied pharmacology 2019 Oct 15;381:114732
Long Noncoding RNA HOXA-AS3 Integrates NF-κB Signaling To Regulate Endothelium Inflammation.
Zhu X, Chen D, Liu Y, Yu J, Qiao L, Lin S, Chen D, Zhong G, Lu X, Wang Y, Wen J, Zhong X, Jiang Y
Molecular and cellular biology 2019 Oct 1;39(19)
Molecular and cellular biology 2019 Oct 1;39(19)
Propofol attenuates the adhesion of tumor and endothelial cells through inhibiting glycolysis in human umbilical vein endothelial cells.
Qi J, Wu Q, Zhu X, Zhang S, Chen X, Chen W, Sun Z, Zhu M, Miao C
Acta biochimica et biophysica Sinica 2019 Nov 18;51(11):1114-1122
Acta biochimica et biophysica Sinica 2019 Nov 18;51(11):1114-1122
LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop.
Zhu X, Du J, Yu J, Guo R, Feng Y, Qiao L, Xu Z, Yang F, Zhong G, Liu F, Cheng F, Chu M, Lin J
Journal of molecular and cellular cardiology 2019 Jan;126:60-69
Journal of molecular and cellular cardiology 2019 Jan;126:60-69
Metformin ameliorates the progression of atherosclerosis via suppressing macrophage infiltration and inflammatory responses in rabbits.
Yang Q, Yuan H, Chen M, Qu J, Wang H, Yu B, Chen J, Sun S, Tang X, Ren W
Life sciences 2018 Apr 1;198:56-64
Life sciences 2018 Apr 1;198:56-64
Tail vein injection of mmLDL upregulates mouse mesenteric artery ET(B) receptors via activation of the ERK1/2 pathway.
Liu Y, Chen XL, Xu CB, Cao L, Lin J, Chen G, Li J
Vascular pharmacology 2017 Sep;96-98:33-39
Vascular pharmacology 2017 Sep;96-98:33-39
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