Antibody data
- Antibody Data
- Antigen structure
- References [1]
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- Product number
- NBP2-47864PECY7 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal VCAM-1/CD106 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. Recognizes a protein of 110kDa, identified as CD106 (also known as vascular cell adhesion molecule-1 (VCAM-1) and INCAM-100). CD106 is a member of the Ig superfamily of adhesion molecules and is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on un-stimulated endothelial cells. It is also present on follicular and inter-follicular dendritic cells of lymph nodes, myoblasts, and some macrophages. CD106 serves as a ligand for leukocyte integrin (VLA-4 or CD49d/CD29) and mediates cell adhesion of leukocytes to activated endothelium. It plays a role in various immunological and inflammatory responses. This MAb inhibits the binding of leukocytes to VCAM-1 on stimulated endothelial cells.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C in the dark. Do not freeze.
Submitted references Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis.
Mutoh T, Shirai T, Ishii T, Shirota Y, Fujishima F, Takahashi F, Kakuta Y, Kanazawa Y, Masamune A, Saiki Y, Harigae H, Fujii H
Nature communications 2020 Mar 9;11(1):1253
Nature communications 2020 Mar 9;11(1):1253
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