Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 305802 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#305802, RRID:AB_314558
- Product name
- Purified anti-human CD106
- Antibody type
- Monoclonal
- Antigen
- CD106
- Description
- CD106 is a 110 kD single chain type I glycoprotein also known as VCAM-1 and INCAM-110. It is expressed predominantly on activated vascular endothelium but has also been identified on follicular and interfollicular dendritic cells, some macrophages, bone marrow stromal cells, and non-vascular cell populations within joints, kidney, muscle, heart, placenta, and brain. Expression on endothelial cells as well as many other cells is induced by inflammatory stimuli and cytokines. Activated endothelial cells can release soluble forms of CD106 which can be detected in the blood. CD106 binds the integrins CD49d/CD29 (VLA-4) and α4β7 that contribute to leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro.
Yen YT, Liao F, Hsiao CH, Kao CL, Chen YC, Wu-Hsieh BA
Journal of virology 2006 Mar;80(6):2684-93
Journal of virology 2006 Mar;80(6):2684-93
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- TNF-α stimulated HUVEC cells stained with purified STA, followed by anti-mouse IgGs FITC
- Conjugate
- Unconjugated