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- Antibody Data
- Antigen structure
- References [75]
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- Immunohistochemistry [1]
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- Product number
- AF-493-NA - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse VEGF164 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse VEGF in ELISAs and Western blots. In Western blots, detection of recombinant mouse (rm) VEGF164, rmVEGF120, rmVEGF188, and recombinant rat VEGF164 is observered but no cross-reactivity with rmVEGF-B167,rmVEGF-B186, or recombinant human (rh) VEGF165 is observed. In sandwich immunoassays, less than 0.04% cross-reactivity with rhVEGF121, rhVEGF165, and rhVEGF/PlGF is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
AAA40547- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Regeneration-associated cell transplantation contributes to tissue recovery in mice with acute ischemic stroke.
Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC.
Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation.
Bushen Huoxue Recipe Alleviates Implantation Loss in Mice by Enhancing Estrogen-Progesterone Signals and Promoting Decidual Angiogenesis Through FGF2 During Early Pregnancy.
Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis.
Vascularization via activation of VEGF-VEGFR signaling is essential for peripheral nerve regeneration.
The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice.
Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity.
Modulation of Salmonella Tumor-Colonization and Intratumoral Anti-angiogenesis by Triptolide and Its Mechanism.
Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes.
A delay in vascularization induces abnormal astrocyte proliferation and migration in the mouse retina.
VEGF as a Paracrine Regulator of Conventional Outflow Facility.
Ferrochelatase is a therapeutic target for ocular neovascularization.
Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration.
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization.
PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently.
A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy.
Endothelial Cords Promote Tumor Initial Growth prior to Vascular Function through a Paracrine Mechanism.
The biomechanical properties of an epithelial tissue determine the location of its vasculature.
Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate.
Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro.
Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.
HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation.
IKK2 inhibition attenuates laser-induced choroidal neovascularization.
RhoA/phosphatidylinositol 3-kinase/protein kinase B/mitogen-activated protein kinase signaling after growth arrest-specific protein 6/mer receptor tyrosine kinase engagement promotes epithelial cell growth and wound repair via upregulation of hepatocyte growth factor in macrophages.
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain.
Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.
MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain.
IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors.
Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor β2 (TGF-β2) pathways.
Shiga toxin promotes podocyte injury in experimental hemolytic uremic syndrome via activation of the alternative pathway of complement.
An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice.
Angiopoietin-1 suppresses choroidal neovascularization and vascular leakage.
Dendritic cells: In vitro culture in two- and three-dimensional collagen systems and expression of collagen receptors in tumors and atherosclerotic microenvironments.
Folic acid mitigates angiotensin-II-induced blood pressure and renal remodeling.
Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D.
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
The role of IL-1β in the early tumor cell-induced angiogenic response.
Response patterns of cytokines/chemokines in two murine strains after irradiation.
Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.
IL-17 and VEGF are necessary for efficient corneal nerve regeneration.
Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization.
Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway.
CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction.
VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis.
Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas.
Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease.
Safety profile of topical VEGF neutralization at the cornea.
Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
Role of cell and matrix-bound VEGF isoforms in lens development.
Fibroblast-type reticular stromal cells regulate the lymph node vasculature.
Fibroblast-type reticular stromal cells regulate the lymph node vasculature.
Regulation of scar formation by vascular endothelial growth factor.
Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1.
Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function.
Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions.
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.
Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone.
Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects.
Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects.
Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization.
CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization.
Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice.
Lack of alpha2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction.
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.
Nakayama T, Nagata E, Masuda H, Asahara T, Takizawa S
PloS one 2019;14(1):e0210198
PloS one 2019;14(1):e0210198
Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC.
John B, Naczki C, Patel C, Ghoneum A, Qasem S, Salih Z, Said N
Oncogene 2019 May;38(22):4366-4383
Oncogene 2019 May;38(22):4366-4383
Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation.
Subileau M, Merdzhanova G, Ciais D, Collin-Faure V, Feige JJ, Bailly S, Vittet D
Stem cell reports 2019 Jan 8;12(1):98-111
Stem cell reports 2019 Jan 8;12(1):98-111
Bushen Huoxue Recipe Alleviates Implantation Loss in Mice by Enhancing Estrogen-Progesterone Signals and Promoting Decidual Angiogenesis Through FGF2 During Early Pregnancy.
Ding J, Tan X, Song K, Ma W, Xiao J, Song Y, Zhang M
Frontiers in pharmacology 2018;9:437
Frontiers in pharmacology 2018;9:437
Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis.
Kobori T, Hamasaki S, Kitaura A, Yamazaki Y, Nishinaka T, Niwa A, Nakao S, Wake H, Mori S, Yoshino T, Nishibori M, Takahashi H
Frontiers in immunology 2018;9:334
Frontiers in immunology 2018;9:334
Vascularization via activation of VEGF-VEGFR signaling is essential for peripheral nerve regeneration.
Nishida Y, Yamada Y, Kanemaru H, Ohazama A, Maeda T, Seo K
Biomedical research (Tokyo, Japan) 2018;39(6):287-294
Biomedical research (Tokyo, Japan) 2018;39(6):287-294
The AB loop of oncostatin M (OSM) determines species-specific signaling in humans and mice.
Adrian-Segarra JM, Sreenivasan K, Gajawada P, Lörchner H, Braun T, Pöling J
The Journal of biological chemistry 2018 Dec 28;293(52):20181-20199
The Journal of biological chemistry 2018 Dec 28;293(52):20181-20199
Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity.
Schrand B, Clark E, Levay A, Capote AR, Martinez O, Brenneman R, Castro I, Gilboa E
Nature communications 2018 Aug 22;9(1):3348
Nature communications 2018 Aug 22;9(1):3348
Modulation of Salmonella Tumor-Colonization and Intratumoral Anti-angiogenesis by Triptolide and Its Mechanism.
Chen J, Qiao Y, Tang B, Chen G, Liu X, Yang B, Wei J, Zhang X, Cheng X, Du P, Jiang W, Hu Q, Hua ZC
Theranostics 2017;7(8):2250-2260
Theranostics 2017;7(8):2250-2260
Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes.
Hara T, Nakaoka HJ, Hayashi T, Mimura K, Hoshino D, Inoue M, Nagamura F, Murakami Y, Seiki M, Sakamoto T
Proceedings of the National Academy of Sciences of the United States of America 2017 May 30;114(22):E4416-E4424
Proceedings of the National Academy of Sciences of the United States of America 2017 May 30;114(22):E4416-E4424
A delay in vascularization induces abnormal astrocyte proliferation and migration in the mouse retina.
Morita A, Ushikubo H, Mori A, Arima S, Sakamoto K, Nagamitsu T, Ishii K, Nakahara T
Developmental dynamics : an official publication of the American Association of Anatomists 2017 Mar;246(3):186-200
Developmental dynamics : an official publication of the American Association of Anatomists 2017 Mar;246(3):186-200
VEGF as a Paracrine Regulator of Conventional Outflow Facility.
Reina-Torres E, Wen JC, Liu KC, Li G, Sherwood JM, Chang JY, Challa P, Flügel-Koch CM, Stamer WD, Allingham RR, Overby DR
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1899-1908
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1899-1908
Ferrochelatase is a therapeutic target for ocular neovascularization.
Basavarajappa HD, Sulaiman RS, Qi X, Shetty T, Sheik Pran Babu S, Sishtla KL, Lee B, Quigley J, Alkhairy S, Briggs CM, Gupta K, Tang B, Shadmand M, Grant MB, Boulton ME, Seo SY, Corson TW
EMBO molecular medicine 2017 Jun;9(6):786-801
EMBO molecular medicine 2017 Jun;9(6):786-801
Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration.
Sun JL, Jiao K, Niu LN, Jiao Y, Song Q, Shen LJ, Tay FR, Chen JH
Biomaterials 2017 Jan;113:203-216
Biomaterials 2017 Jan;113:203-216
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
Chen XW, Yu TJ, Zhang J, Li Y, Chen HL, Yang GF, Yu W, Liu YZ, Liu XX, Duan CF, Tang HL, Qiu M, Wang CL, Zheng H, Yue J, Guo AM, Yang J
Oncogene 2017 Aug 31;36(35):5045-5057
Oncogene 2017 Aug 31;36(35):5045-5057
Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization.
Wang H, Han X, Bretz CA, Becker S, Gambhir D, Smith GW, Samulski RJ, Wittchen ES, Quilliam LA, Chrzanowska-Wodnicka M, Hartnett ME
Molecular therapy. Methods & clinical development 2016;3:16056
Molecular therapy. Methods & clinical development 2016;3:16056
PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently.
Zheng L, Zhao C, Du Y, Lin X, Jiang Y, Lee C, Tian G, Mi J, Li X, Chen Q, Ye Z, Huang L, Wang S, Ren X, Xing L, Chen W, Huang D, Gao Z, Zhang S, Lu W, Tang Z, Wang B, Ju R, Li X
Oncotarget 2016 Nov 22;7(47):77902-77915
Oncotarget 2016 Nov 22;7(47):77902-77915
A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy.
Sulaiman RS, Merrigan S, Quigley J, Qi X, Lee B, Boulton ME, Kennedy B, Seo SY, Corson TW
Scientific reports 2016 May 5;6:25509
Scientific reports 2016 May 5;6:25509
Endothelial Cords Promote Tumor Initial Growth prior to Vascular Function through a Paracrine Mechanism.
Zhao C, Zhang W, Zhao Y, Yang Y, Luo H, Ji G, Dong E, Deng H, Lin S, Wei Y, Yang H
Scientific reports 2016 Jan 14;6:19404
Scientific reports 2016 Jan 14;6:19404
The biomechanical properties of an epithelial tissue determine the location of its vasculature.
Kragl M, Schubert R, Karsjens H, Otter S, Bartosinska B, Jeruschke K, Weiss J, Chen C, Alsteens D, Kuss O, Speier S, Eberhard D, Müller DJ, Lammert E
Nature communications 2016 Dec 20;7:13560
Nature communications 2016 Dec 20;7:13560
Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate.
Limani P, Linecker M, Kachaylo E, Tschuor C, Kron P, Schlegel A, Ungethuem U, Jang JH, Georgiopoulou S, Nicolau C, Lehn JM, Graf R, Humar B, Clavien PA
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Dec 1;22(23):5887-5897
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Dec 1;22(23):5887-5897
Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro.
Khabbazi S, Nassar ZD, Goumon Y, Parat MO
Scientific reports 2016 Aug 12;6:31572
Scientific reports 2016 Aug 12;6:31572
Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.
Sitaras N, Rivera JC, Noueihed B, Bien-Aimé M, Zaniolo K, Omri S, Hamel D, Zhu T, Hardy P, Sapieha P, Joyal JS, Chemtob S
The American journal of pathology 2015 Feb;185(2):581-95
The American journal of pathology 2015 Feb;185(2):581-95
HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation.
Park SY, Lee SW, Kim HY, Lee WS, Hong KW, Kim CD
European journal of immunology 2015 Apr;45(4):1216-27
European journal of immunology 2015 Apr;45(4):1216-27
IKK2 inhibition attenuates laser-induced choroidal neovascularization.
Lu H, Lu Q, Gaddipati S, Kasetti RB, Wang W, Pasparakis M, Kaplan HJ, Li Q
PloS one 2014;9(1):e87530
PloS one 2014;9(1):e87530
RhoA/phosphatidylinositol 3-kinase/protein kinase B/mitogen-activated protein kinase signaling after growth arrest-specific protein 6/mer receptor tyrosine kinase engagement promotes epithelial cell growth and wound repair via upregulation of hepatocyte growth factor in macrophages.
Lee YJ, Park HJ, Woo SY, Park EM, Kang JL
The Journal of pharmacology and experimental therapeutics 2014 Sep;350(3):563-77
The Journal of pharmacology and experimental therapeutics 2014 Sep;350(3):563-77
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
Lee E, Fertig EJ, Jin K, Sukumar S, Pandey NB, Popel AS
Nature communications 2014 Sep 2;5:4715
Nature communications 2014 Sep 2;5:4715
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
Bonapace L, Coissieux MM, Wyckoff J, Mertz KD, Varga Z, Junt T, Bentires-Alj M
Nature 2014 Nov 6;515(7525):130-3
Nature 2014 Nov 6;515(7525):130-3
Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain.
Yu S, Levi L, Casadesus G, Kunos G, Noy N
The Journal of biological chemistry 2014 May 2;289(18):12748-58
The Journal of biological chemistry 2014 May 2;289(18):12748-58
Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.
Hendel A, Hsu I, Granville DJ
Laboratory investigation; a journal of technical methods and pathology 2014 Jul;94(7):716-25
Laboratory investigation; a journal of technical methods and pathology 2014 Jul;94(7):716-25
MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain.
Zeng L, He X, Wang Y, Tang Y, Zheng C, Cai H, Liu J, Wang Y, Fu Y, Yang GY
Gene therapy 2014 Jan;21(1):37-43
Gene therapy 2014 Jan;21(1):37-43
IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors.
Valcárcel M, Carrascal T, Crende O, Vidal-Vanaclocha F
The Journal of investigative dermatology 2014 Feb;134(2):470-480
The Journal of investigative dermatology 2014 Feb;134(2):470-480
Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor β2 (TGF-β2) pathways.
Di Bernardini E, Campagnolo P, Margariti A, Zampetaki A, Karamariti E, Hu Y, Xu Q
The Journal of biological chemistry 2014 Feb 7;289(6):3383-93
The Journal of biological chemistry 2014 Feb 7;289(6):3383-93
Shiga toxin promotes podocyte injury in experimental hemolytic uremic syndrome via activation of the alternative pathway of complement.
Locatelli M, Buelli S, Pezzotta A, Corna D, Perico L, Tomasoni S, Rottoli D, Rizzo P, Conti D, Thurman JM, Remuzzi G, Zoja C, Morigi M
Journal of the American Society of Nephrology : JASN 2014 Aug;25(8):1786-98
Journal of the American Society of Nephrology : JASN 2014 Aug;25(8):1786-98
An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice.
Runge A, Hu J, Wieland M, Bergeest JP, Mogler C, Neumann A, Géraud C, Arnold B, Rohr K, Komljenovic D, Schirmacher P, Goerdt S, Augustin HG
Cancer research 2014 Aug 1;74(15):4157-69
Cancer research 2014 Aug 1;74(15):4157-69
Angiopoietin-1 suppresses choroidal neovascularization and vascular leakage.
Lee J, Park DY, Park DY, Park I, Chang W, Nakaoka Y, Komuro I, Yoo OJ, Koh GY
Investigative ophthalmology & visual science 2014 Apr 7;55(4):2191-9
Investigative ophthalmology & visual science 2014 Apr 7;55(4):2191-9
Dendritic cells: In vitro culture in two- and three-dimensional collagen systems and expression of collagen receptors in tumors and atherosclerotic microenvironments.
Sprague L, Muccioli M, Pate M, Singh M, Xiong C, Ostermann A, Niese B, Li Y, Li Y, Courreges MC, Benencia F
Experimental cell research 2014 Apr 15;323(1):7-27
Experimental cell research 2014 Apr 15;323(1):7-27
Folic acid mitigates angiotensin-II-induced blood pressure and renal remodeling.
Pushpakumar SB, Kundu S, Metreveli N, Sen U
PloS one 2013;8(12):e83813
PloS one 2013;8(12):e83813
Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D.
Tan KW, Chong SZ, Wong FH, Evrard M, Tan SM, Keeble J, Kemeny DM, Ng LG, Abastado JP, Angeli V
Blood 2013 Nov 21;122(22):3666-77
Blood 2013 Nov 21;122(22):3666-77
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Raghuwanshi SK, Smith N, Rivers EJ, Thomas AJ, Sutton N, Hu Y, Mukhopadhyay S, Chen XL, Leung T, Richardson RM
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):5329-36
Journal of immunology (Baltimore, Md. : 1950) 2013 May 15;190(10):5329-36
The role of IL-1β in the early tumor cell-induced angiogenic response.
Carmi Y, Dotan S, Rider P, Kaplanov I, White MR, Baron R, Abutbul S, Huszar M, Dinarello CA, Apte RN, Voronov E
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3500-9
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3500-9
Response patterns of cytokines/chemokines in two murine strains after irradiation.
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L
Cytokine 2012 May;58(2):169-77
Cytokine 2012 May;58(2):169-77
Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.
Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Dan T, Miyata T, Okumura K, Tomiki Y, Sakamoto K, Nakauchi H, Heissig B, Hattori K
Blood 2012 Jun 28;119(26):6382-93
Blood 2012 Jun 28;119(26):6382-93
IL-17 and VEGF are necessary for efficient corneal nerve regeneration.
Li Z, Burns AR, Han L, Rumbaut RE, Smith CW
The American journal of pathology 2011 Mar;178(3):1106-16
The American journal of pathology 2011 Mar;178(3):1106-16
Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization.
Liu J, Jha P, Lyzogubov VV, Tytarenko RG, Bora NS, Bora PS
The Journal of biological chemistry 2011 Jun 10;286(23):20991-1001
The Journal of biological chemistry 2011 Jun 10;286(23):20991-1001
Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway.
Furrer K, Rickenbacher A, Tian Y, Jochum W, Bittermann AG, Käch A, Humar B, Graf R, Moritz W, Clavien PA
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 15;108(7):2945-50
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 15;108(7):2945-50
CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction.
Jujo K, Hamada H, Iwakura A, Thorne T, Sekiguchi H, Clarke T, Ito A, Misener S, Tanaka T, Klyachko E, Kobayashi K, Tongers J, Roncalli J, Tsurumi Y, Hagiwara N, Losordo DW
Proceedings of the National Academy of Sciences of the United States of America 2010 Jun 15;107(24):11008-13
Proceedings of the National Academy of Sciences of the United States of America 2010 Jun 15;107(24):11008-13
VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis.
Wuest TR, Carr DJ
The Journal of experimental medicine 2010 Jan 18;207(1):101-15
The Journal of experimental medicine 2010 Jan 18;207(1):101-15
Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas.
Lederle W, Linde N, Heusel J, Bzyl J, Woenne EC, Zwick S, Skobe M, Kiessling F, Fusenig NE, Mueller MM
The American journal of pathology 2010 Feb;176(2):981-94
The American journal of pathology 2010 Feb;176(2):981-94
Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease.
Hakroush S, Moeller MJ, Theilig F, Kaissling B, Sijmonsma TP, Jugold M, Akeson AL, Traykova-Brauch M, Hosser H, Hähnel B, Gröne HJ, Koesters R, Kriz W
The American journal of pathology 2009 Nov;175(5):1883-95
The American journal of pathology 2009 Nov;175(5):1883-95
Safety profile of topical VEGF neutralization at the cornea.
Bock F, Onderka J, Rummelt C, Dietrich T, Bachmann B, Kruse FE, Schlötzer-Schrehardt U, Cursiefen C
Investigative ophthalmology & visual science 2009 May;50(5):2095-102
Investigative ophthalmology & visual science 2009 May;50(5):2095-102
Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.
Kataru RP, Jung K, Jang C, Yang H, Schwendener RA, Baik JE, Han SH, Alitalo K, Koh GY
Blood 2009 May 28;113(22):5650-9
Blood 2009 May 28;113(22):5650-9
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, Marx SJ, Spiegel AM, Libutti SK
Cancer research 2009 Mar 1;69(5):1858-66
Cancer research 2009 Mar 1;69(5):1858-66
Role of cell and matrix-bound VEGF isoforms in lens development.
Saint-Geniez M, Kurihara T, D'Amore PA
Investigative ophthalmology & visual science 2009 Jan;50(1):311-21
Investigative ophthalmology & visual science 2009 Jan;50(1):311-21
Fibroblast-type reticular stromal cells regulate the lymph node vasculature.
Chyou S, Ekland EH, Carpenter AC, Tzeng TC, Tian S, Michaud M, Madri JA, Lu TT
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 15;181(6):3887-96
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 15;181(6):3887-96
Fibroblast-type reticular stromal cells regulate the lymph node vasculature.
Chyou S, Ekland EH, Carpenter AC, Tzeng TC, Tian S, Michaud M, Madri JA, Lu TT
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 15;181(6):3887-96
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 15;181(6):3887-96
Regulation of scar formation by vascular endothelial growth factor.
Wilgus TA, Ferreira AM, Oberyszyn TM, Bergdall VK, Dipietro LA
Laboratory investigation; a journal of technical methods and pathology 2008 Jun;88(6):579-90
Laboratory investigation; a journal of technical methods and pathology 2008 Jun;88(6):579-90
Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1.
Ponticelli S, Marasco D, Tarallo V, Albuquerque RJ, Mitola S, Takeda A, Stassen JM, Presta M, Ambati J, Ruvo M, De Falco S
The Journal of biological chemistry 2008 Dec 5;283(49):34250-9
The Journal of biological chemistry 2008 Dec 5;283(49):34250-9
Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.
Blouw B, Haase VH, Song H, Bergers G, Johnson RS
Oncogene 2007 Jul 5;26(31):4531-40
Oncogene 2007 Jul 5;26(31):4531-40
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI
Genes & development 2006 Sep 15;20(18):2527-38
Genes & development 2006 Sep 15;20(18):2527-38
Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function.
Kajiya K, Hirakawa S, Detmar M
The American journal of pathology 2006 Oct;169(4):1496-503
The American journal of pathology 2006 Oct;169(4):1496-503
Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
Lederle W, Stark HJ, Skobe M, Fusenig NE, Mueller MM
The American journal of pathology 2006 Nov;169(5):1767-83
The American journal of pathology 2006 Nov;169(5):1767-83
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL
Nature neuroscience 2006 Mar;9(3):340-8
Nature neuroscience 2006 Mar;9(3):340-8
Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions.
Cahill RA, Wang JH, Soohkai S, Redmond HP
Surgery 2006 Jul;140(1):108-12
Surgery 2006 Jul;140(1):108-12
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.
Nozaki M, Sakurai E, Raisler BJ, Baffi JZ, Witta J, Ogura Y, Brekken RA, Sage EH, Ambati BK, Ambati J
The Journal of clinical investigation 2006 Feb;116(2):422-9
The Journal of clinical investigation 2006 Feb;116(2):422-9
Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone.
Katsube K, Bishop AT, Simari RD, Ylä-Herttuala S, Friedrich PF
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005 Mar;23(2):469-74
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005 Mar;23(2):469-74
Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects.
Kim B, Lee S, Suvas S, Rouse BT
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 1;175(1):509-16
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 1;175(1):509-16
Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects.
Kim B, Lee S, Suvas S, Rouse BT
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 1;175(1):509-16
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 1;175(1):509-16
Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 1;174(1):215-22
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 1;174(1):215-22
Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 1;174(1):215-22
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 1;174(1):215-22
CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization.
Banerjee K, Biswas PS, Kim B, Lee S, Rouse BT
Journal of immunology (Baltimore, Md. : 1950) 2004 Jan 15;172(2):1237-45
Journal of immunology (Baltimore, Md. : 1950) 2004 Jan 15;172(2):1237-45
CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization.
Banerjee K, Biswas PS, Kim B, Lee S, Rouse BT
Journal of immunology (Baltimore, Md. : 1950) 2004 Jan 15;172(2):1237-45
Journal of immunology (Baltimore, Md. : 1950) 2004 Jan 15;172(2):1237-45
Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice.
Kodama I, Niida S, Sanada M, Yoshiko Y, Tsuda M, Maeda N, Ohama K
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 Feb;19(2):200-6
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 Feb;19(2):200-6
Lack of alpha2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction.
Matsuno H, Kozawa O, Yoshimi N, Akamatsu S, Hara A, Mori H, Okada K, Ueshima S, Matsuo O, Uematsu T
Blood 2002 Oct 1;100(7):2487-93
Blood 2002 Oct 1;100(7):2487-93
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.
Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP
Clinical cancer research : an official journal of the American Association for Cancer Research 1999 Oct;5(10):2963-70
Clinical cancer research : an official journal of the American Association for Cancer Research 1999 Oct;5(10):2963-70
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Supportive validation
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- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Recombinant Human, Mouse, and Rat VEGF by Western Blot. Western blot shows 25 ng of Recombinant Human VEGF165 (Catalog # 293-VE), Recombinant Mouse VEGF164 (Catalog # 493-MV), Recombinant Mouse VEGF120 (Catalog # 494-VE), Recombinant Mouse VEGF-B167 (Catalog # 2595-VE), Recombinant Mouse VEGF-B 186 (Catalog # 767-VE), Recombinant Mouse VEGF188 (Catalog # 7916-MV), and Recombinant Rat VEGF164 (Catalog # 564-RV). PVDF Membrane was probed with 0.1 µg/mL of Goat Anti-Mouse VEGF164 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-493-NA) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for VEGF at approximately 18-27 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.
Supportive validation
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- R&D Systems (provider)
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- Experimental details
- VEGF164 in Mouse Kidney. Vascular Endothelial Growth Factor 164 (VEGF164) was detected in perfusion fixed frozen sections of mouse kidney using Goat Anti-Mouse VEGF164 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-493-NA) at 15 µg/mL overnight at 4 °C. Tissue was stained (red) and counterstained (green). View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Cell Proliferation Induced by VEGF164 and Neutralization by Mouse VEGF Antibody. Recombinant Mouse VEGF164 (Catalog # 493-MV) stimulates proliferation in HUVEC human umbilical vein endothelial cells in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse VEGF164 (10 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse VEGF164 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-493-NA). The ND50 is typically 0.05-0.15 µg/mL.
