Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-BL2334 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-MBD1 monoclonal antibody, clone 3C21
- Antibody type
- Monoclonal
- Description
- Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone Lys-9 trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3C21
- Storage
- Store at -2°C or lower. Aliquot to avoid repeated freezing and thawing.
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