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- References [15]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 20705-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20705-1-AP, RRID:AB_10695762
- Product name
- TOP1 antibody
- Antibody type
- Polyclonal
- Description
- TOP1 antibody (Cat. #20705-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway.
Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1.
Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer.
HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.
Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling.
Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons.
Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype.
EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells.
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence.
IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression.
Treatment mechanism of matrine in combination with irinotecan for colon cancer.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Genetic variants in microRNAs predict non-small cell lung cancer prognosis in Chinese female population in a prospective cohort study.
Gong Y, Wang J, Pan M, Zhao Y, Zhang H, Zhang F, Liu J, Yang J, Hu J
International immunopharmacology 2024 Sep 10;138:112542
International immunopharmacology 2024 Sep 10;138:112542
Integrated multi-omics analyses reveal Jorunnamycin A as a novel suppressor for muscle-invasive bladder cancer by targeting FASN and TOP1.
Chen R, Hao X, Chen J, Zhang C, Fan H, Lian F, Chen X, Wang C, Xia Y
Journal of translational medicine 2023 Aug 16;21(1):549
Journal of translational medicine 2023 Aug 16;21(1):549
Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer.
Hou L, Hou Y, Liang Y, Chen B, Zhang X, Wang Y, Zhou K, Zhong T, Long B, Pang W, Wang L, Han X, Li L, Xu C, Gross I, Gaiddon C, Fu W, Yao H, Meng X
Communications biology 2022 Nov 14;5(1):1248
Communications biology 2022 Nov 14;5(1):1248
HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer.
Ma H, Qi G, Han F, Lu W, Peng J, Li R, Yan S, Yuan C, Kong B
Cell death & disease 2022 Mar 24;13(3):263
Cell death & disease 2022 Mar 24;13(3):263
Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling.
Cai D, Han JJ
Nature aging 2021 May;1(5):438-453
Nature aging 2021 May;1(5):438-453
Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons.
Flor A, Wolfgeher D, Li J, Hanakahi LA, Kron SJ
Cell chemical biology 2021 Jun 17;28(6):776-787.e8
Cell chemical biology 2021 Jun 17;28(6):776-787.e8
Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype.
Hao X, Zhao B, Zhou W, Liu H, Fukumoto T, Gabrilovich D, Zhang R
iScience 2021 Jan 22;24(1):102016
iScience 2021 Jan 22;24(1):102016
EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells.
Wu W, Dong J, Gou H, Geng R, Yang X, Chen D, Xiang B, Zhang Z, Ren S, Chen L, Liu J
Journal of cellular and molecular medicine 2021 Aug;25(16):7913-7921
Journal of cellular and molecular medicine 2021 Aug;25(16):7913-7921
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence.
Zhao B, Liu P, Fukumoto T, Nacarelli T, Fatkhutdinov N, Wu S, Lin J, Aird KM, Tang HY, Liu Q, Speicher DW, Zhang R
Nature communications 2020 Feb 19;11(1):908
Nature communications 2020 Feb 19;11(1):908
IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Yin H, Jiang Z, Wang S, Zhang P
Cell death & disease 2019 Sep 9;10(9):642
Cell death & disease 2019 Sep 9;10(9):642
Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression.
Li J, Shi J, Pan Y, Zhao Y, Yan F, Li H, Lei L
Scientific reports 2019 Nov 22;9(1):17369
Scientific reports 2019 Nov 22;9(1):17369
Treatment mechanism of matrine in combination with irinotecan for colon cancer.
Duan L, Deng L, Wang D, Ma S, Li C, Zhao D
Oncology letters 2017 Aug;14(2):2300-2304
Oncology letters 2017 Aug;14(2):2300-2304
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Gao L, Xu Z, Wang Y, Sun B, Song Z, Yang B, Liu X, Lin Y, Peng J, Han G, Wang S, Tang Z
Oncology reports 2016 Feb;35(2):1101-8
Oncology reports 2016 Feb;35(2):1101-8
Genetic variants in microRNAs predict non-small cell lung cancer prognosis in Chinese female population in a prospective cohort study.
Lingzi X, Zhihua Y, Xuelian L, Yangwu R, Haibo Z, Yuxia Z, Baosen Z
Oncotarget 2016 Dec 13;7(50):83101-83114
Oncotarget 2016 Dec 13;7(50):83101-83114
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- L02 cells were subjected to SDS PAGE followed by western blot with 20705-1-AP(TOP1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TOP1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human TOP1. This antibody recognizes human,mouse,rat antigen. The TOP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
